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21 results on '"Kantauskaite, Marta"'

5. Contrast medium free selective adrenal vein sampling in the management of primary aldosteronism

Author

Boschheidgen, Matthias, primary, Kantauskaite, Marta, additional, Stegbauer, Johannes, additional, Wenker, Kira, additional, Dringenberg, Till, additional, Radke, Karl-Ludger, additional, Ullrich, Tim, additional, Krieg, Andreas, additional, Steuwe, Andrea, additional, Minko, Peter, additional, Schott, Matthias, additional, Rump, Lars Christian, additional, Antoch, Gerald, additional, and Schimmöller, Lars, additional

Published
2023
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6. The Effect of Renal Denervation on T Cells in Patients with Resistant Hypertension

Author

Kantauskaite, Marta, primary, Vonend, Oliver, additional, Yakoub, Mina, additional, Heilmann, Philipp, additional, Maifeld, Andras, additional, Minko, Peter, additional, Schimmöller, Lars, additional, Antoch, Gerald, additional, Müller, Dominik N., additional, Schmidt, Claudia, additional, Duvnjak, Blanka, additional, Zierhut, Ulf, additional, Potthoff, Sebastian A., additional, Rump, Lars C., additional, Fischer, Johannes C., additional, and Stegbauer, Johannes, additional

Published
2023
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9. Factors Associated With Vaccine-Induced T-Cell Immune Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Kidney Transplant Recipients

Author

Tometten, Inga, primary, Landmann, Sinje, additional, Kantauskaite, Marta, additional, Lamberti, Joshua, additional, Hillebrandt, Jonas, additional, Müller, Lisa, additional, Kittel, Margarethe, additional, Kolb, Thilo, additional, Ivens, Katrin, additional, Schmitz, Michael, additional, Voges, Anja, additional, Adams, Ortwin, additional, Andrée, Marcel, additional, Schaal, Heiner, additional, Lübke, Nadine, additional, Königshausen, Eva, additional, Rump, Lars Christian, additional, Stegbauer, Johannes, additional, and Timm, Jörg, additional

Published
2022
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10. Development and validation of multivariable prediction models of serological response to SARS-CoV-2 vaccination in kidney transplant recipients

Author

Osmanodja, Bilgin, primary, Stegbauer, Johannes, additional, Kantauskaite, Marta, additional, Rump, Lars Christian, additional, Heinzel, Andreas, additional, Reindl-Schwaighofer, Roman, additional, Oberbauer, Rainer, additional, Benotmane, Ilies, additional, Caillard, Sophie, additional, Masset, Christophe, additional, Kerleau, Clarisse, additional, Blancho, Gilles, additional, Budde, Klemens, additional, Grunow, Fritz, additional, Mikhailov, Michael, additional, Schrezenmeier, Eva, additional, and Ronicke, Simon, additional

Published
2022
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11. Immune response to third SARS‐CoV‐2 vaccination in seronegative kidney transplant recipients: Possible improvement by mycophenolate mofetil reduction

Author

Kantauskaite, Marta, primary, Müller, Lisa, additional, Hillebrandt, Jonas, additional, Lamberti, Joshua, additional, Fischer, Svenja, additional, Kolb, Thilo, additional, Ivens, Katrin, additional, Koch, Michael, additional, Andree, Marcel, additional, Lübke, Nadine, additional, Schmitz, Michael, additional, Luedde, Tom, additional, Orth, Hans Martin, additional, Feldt, Torsten, additional, Schaal, Heiner, additional, Adams, Ortwin, additional, Schmidt, Claudia, additional, Kittel, Margarethe, additional, Königshausen, Eva, additional, Rump, Lars C., additional, Timm, Jörg, additional, and Stegbauer, Johannes, additional

Published
2022
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13. Factors associated with vaccine-induced T cell immune responses against SARS-CoV-2 in kidney transplant recipients.

Author

Tometten, Inga, Landmann, Sinje, Kantauskaite, Marta, Lamberti, Joshua, Hillebrandt, Jonas, Müller, Lisa, Kittel, Margarethe, Kolb, Thilo, Ivens, Katrin, Schmitz, Michael, Voges, Anja, Adams, Ortwin, Andrée, Marcel, Schaal, Heiner, Lübke, Nadine, Königshausen, Eva, Rump, Lars Christian, Stegbauer, Johannes, and Timm, Jörg

Subjects
SARS-CoV-2, KIDNEY transplantation, IMMUNE response, T cells
Abstract

Vaccination against SARS-CoV-2 is an important prophylactic measure in kidney transplant recipients (KTRs), however, the immune response is often impaired. Here, we examined the T cell immune response against SARS-CoV-2 in 148 KTRs after three or four vaccine doses including 35 KTRs with subsequent SARS-CoV-2 infection. The frequency of spike-specific T cells was lower in KTRs compared to immunocompetent controls and correlated with the level of spike-specific antibodies. Positive predictors for detection of vaccine-induced T cells were detection of spike-specific antibodies, heterologous immunization with mRNA and a vector vaccine and longer time past transplant. In vaccinated KTRs with subsequent SARS-CoV-2 infection, the T-cell response was greatly enhanced and was significantly higher than in vaccinated KTRs without SARS-CoV-2 infection. Overall, the data show a correlation between impaired humoral and T-cell immunity to SARS-CoV-2 vaccination and provide evidence for greater robustness of hybrid immunity in KTRs. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Transient High Salt Intake Promotes T-Cell-Mediated Hypertensive Vascular Injury.

Author

Yakoub M, Rahman M, Kleimann P, Hoffe J, Feige M, Bouvain P, Alter C, Kluczny JI, Reidel S, Nederlof R, Hering L, Argov D, Arifaj D, Kantauskaite M, Meister J, Kleinewietfeld M, Rump LC, Jantsch J, Flögel U, Müller DN, Temme S, and Stegbauer J

Abstract

Background: Dietary high salt (HS) intake has a strong impact on cardiovascular diseases. Here, we investigated the link between HS-aggravated immune responses and the development of hypertensive vascular disease., Methods: ApolipoproteinE-deficient mice were transiently treated with HS (1% NaCl) via drinking water for 2 weeks, followed by a washout period, and subsequent Ang II (angiotensin II) infusion (1000 ng/kg per min for 10 days) to induce abdominal aortic aneurysms/dissections and inflammation., Results: While transient HS intake alone triggered nonpathologic infiltration of activated T cells into the aorta, subsequent Ang II infusion increased mortality and the incidence of abdominal aortic aneurysms/dissections and atherosclerosis compared with hypertensive control mice. There were no differences in blood pressure between both groups. In transient HS-treated hypertensive mice, the aortic injury was associated with increased inflammation, accumulation of neutrophils, monocytes, CD69 + CD4 + T cells, as well as CD4 + and CD8 + memory T cells. Mechanistically, transient HS intake increased expression levels of aortic RORγt as well as splenic CD4 + T H 17 and CD8 + T C 1 T cells in Ang II-treated mice. Isolated aortas of untreated mice were incubated with supernatants of T H 17, T H 1, or T C 1 cells polarized in vitro under HS or normal conditions which revealed that secreted factors of HS-differentiated T H 17 and T C 1 cells, but not T H 1 cells accelerated endothelial dysfunction., Conclusions: Our data suggest that transient HS intake induces a subclinical T-cell-mediated aortic immune response, which is enhanced by Ang II. We propose a 2-hit model, in which HS acts as a predisposing factor to enhance hypertension-induced T H 17 and T C 1 polarization and aortic disease.

Published
2024
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21. Factors Associated With Vaccine-Induced T-Cell Immune Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Kidney Transplant Recipients.

Author

Tometten I, Landmann S, Kantauskaite M, Lamberti J, Hillebrandt J, Müller L, Kittel M, Kolb T, Ivens K, Schmitz M, Voges A, Adams O, Andrée M, Schaal H, Lübke N, Königshausen E, Rump LC, Stegbauer J, and Timm J

Subjects
Humans, SARS-CoV-2, COVID-19 Vaccines, T-Lymphocytes, Transplant Recipients, Antibodies, Immunity, COVID-19, Kidney Transplantation, Vaccines
Abstract

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important prophylactic measure in kidney transplant recipients (KTRs), but the immune response is often impaired. Here, we examined the T-cell immune response against SARS-CoV-2 in 148 KTRs after 3 or 4 vaccine doses, including 35 KTRs with subsequent SARS-CoV-2 infection. The frequency of spike-specific T cells was lower in KTRs than in immunocompetent controls and was correlated with the level of spike-specific antibodies. Positive predictors for detection of vaccine-induced T cells were detection of spike-specific antibodies, heterologous immunization with messenger RNA and a vector vaccine, and longer time after transplantation. In vaccinated KTRs with subsequent SARS-CoV-2 infection, the T-cell response was greatly enhanced and was significantly higher than in vaccinated KTRs without SARS-CoV-2 infection. Overall, the data show a correlation between impaired humoral and T-cell immunity to SARS-CoV-2 vaccination and provide evidence for greater robustness of hybrid immunity in KTRs., Competing Interests: Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2023
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