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1. Excess All-Cause Deaths during Coronavirus Disease Pandemic, Japan, January-May 20201

Author

Kawashima, Takayuki, Nomura, Shuhei, Tanoue, Yuta, Yoneoka, Daisuke, Eguchi, Akifumi, Ng, Chris Fook Sheng, Matsuura, Kentaro, Shi, Shoi, Makiyama, Koji, Uryu, Shinya, Kawamura, Yumi, Takayanagi, Shinichi, Gilmour, Stuart, Miyata, Hiroaki, Sunagawa, Tomimasa, Takahashi, Takuri, Tsuchihashi, Yuuki, Kobayashi, Yusuke, Arima, Yuzo, Kanou, Kazuhiko, Suzuki, Motoi, and Hashizume, Masahiro

Subjects
Epidemics -- Statistics, Mortality -- Statistics -- Japan, Health
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared in December 2019 in Wuhan, China, and has rapidly led to a global pandemic (1). Globally, accurate figures on deaths caused [...]

Published
2021
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2. Epidemiologic trends and distributions of imported infectious diseases among travelers to Japan before and during the COVID-19 pandemic, 2016 to 2021: a descriptive study

Author

Kasamatsu, Ayu, primary, Kanou, Kazuhiko, additional, Fukusumi, Munehisa, additional, Arima, Yuzo, additional, Omori, Shun, additional, Nakamura, Haruna, additional, Sato, Tetsuro, additional, Serizawa, Yusuke, additional, Takeda, Asuka, additional, Fujikura, Hiroyuki, additional, Ikenoue, Chiaki, additional, Nishiki, Shingo, additional, Fujiya, Yoshihiro, additional, Arashiro, Takeshi, additional, Takahashi, Takuri, additional, Shimada, Tomoe, additional, Suzuki, Motoi, additional, and Sunagawa, Tomimasa, additional

Published
2023
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3. Nationwide epidemiologic and genetic surveillance of hepatitis E in Japan, 2014–2021.

Author

Sugiyama, Ryuichi, Takahara, Osamu, Yahata, Yuichiro, Kanou, Kazuhiko, Nagashima, Mami, Kiyohara, Tomoko, Li, Tian‐Cheng, Arima, Yuzo, Shinomiya, Hiroto, Ishii, Koji, Muramatsu, Masamichi, and Suzuki, Ryosuke

Subjects
HEPATITIS E, HEPATITIS E virus, VIRUS diversity, CHRONIC active hepatitis, GENETIC variation, MOLECULAR virology
Abstract

Hepatitis E virus (HEV) is an emerging causative agent of acute hepatitis. To clarify the epidemiology of HEV and characterize the genetic diversity of the virus in Japan, nationwide enhanced surveillance and molecular characterization studies of HEV in Japan were undertaken from 2014 to 2021. In total, 2770 hepatitis E cases were reported, of which 88% were domestic cases, while only 4.1% represented cases following infection abroad. In addition, 57% of domestic infections occurred in males aged in their 40s–70s. For domestic cases, infection via pork meat consumption continued to be the most reported route. Analysis of the 324 sequences detected between 2016 and 2021 showed that the majority of domestic HEV strains belong to Genotype 3a (G3a) and G3b. In contrast, six of eight cases of G1 HEV reflected infection abroad. Our results suggest that HEV is circulating widely in Japan, with genotypes G3a and G3b being most prevalent. Continued surveillance is necessary to monitor future trends and changes in the epidemiology of HEV in Japan. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Reduced mortality during the COVID-19 outbreak in Japan, 2020: a two-stage interrupted time-series design

Author

Onozuka, Daisuke, primary, Tanoue, Yuta, additional, Nomura, Shuhei, additional, Kawashima, Takayuki, additional, Yoneoka, Daisuke, additional, Eguchi, Akifumi, additional, Ng, Chris Fook Sheng, additional, Matsuura, Kentaro, additional, Shi, Shoi, additional, Makiyama, Koji, additional, Uryu, Shinya, additional, Kawamura, Yumi, additional, Takayanagi, Shinichi, additional, Gilmour, Stuart, additional, Hayashi, Takehiko I, additional, Miyata, Hiroaki, additional, Sera, Francesco, additional, Sunagawa, Tomimasa, additional, Takahashi, Takuri, additional, Tsuchihashi, Yuuki, additional, Kobayashi, Yusuke, additional, Arima, Yuzo, additional, Kanou, Kazuhiko, additional, Suzuki, Motoi, additional, and Hashizume, Masahiro, additional

Published
2021
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5. Viral and Immunological Characteristics of COVID-19 Vaccine Breakthrough Infections

Author

Arashiro, Takeshi, primary, Kanno, Takayuki, additional, Miyamoto, Sho, additional, Saito, Shinji, additional, Moriyama, Saya, additional, Sekizuka, Tsuyoshi, additional, Kanou, Kazuhiko, additional, Stucky, Ashley, additional, Iida, Shun, additional, Ainai, Akira, additional, Katano, Harutaka, additional, Kageyama, Tsutomu, additional, Hanaoka, Nozomu, additional, Saito, Masumichi, additional, Fujimoto, Tsuguto, additional, Kawana-Tachikawa, Ai, additional, Matano, Tetsuro, additional, Kobayashi, Yusuke, additional, Arima, Yuzo, additional, Ota, Masayuki, additional, Kasamatsu, Ayu, additional, Oba, Kunihiro, additional, Nakamura-Uchiyama, Fukumi, additional, Shimizu, Hidefumi, additional, Saito, Tomoya, additional, Takeshita, Nozomi, additional, Ohnishi, Makoto, additional, Wakita, Takaji, additional, Suzuki, Motoi, additional, Kuroda, Makoto, additional, Takahashi, Yoshimasa, additional, and Suzuki, Tadaki, additional

Published
2021
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7. Topology of AspT, the aspartate:alanine antiporter of Tetragenococcus halophilus, determined by site-directed fluorescence labeling

Author

Nanatani, Kei, Fujiki, Takashi, Kanou, Kazuhiko, Takeda-Shitaka, Mayuko, Umeyama, Hideaki, Ye, Liwen, Wang, Xicheng, Nakajima, Tasuku, Uchida, Takafumi, Maloney, Peter C., and Abe, Keietsu

Subjects
Aspartate -- Structure, Aspartate -- Properties, Aspartate -- Influence, Algebraic topology -- Research, Topology -- Research, Bacteriology -- Research, Biological sciences
Abstract

The gram-positive lactic acid bacterium Tetragenococcus halophilus catalyzes the decarboxylation of Laspartate Asp) with release of L-alanine (Ala) and C[O.sub.2]. The decarboxylation reaction consists of two steps: electrogenic exchange of Asp for Ala catalyzed by an aspartate:alanine antiporter (AspT) and intracellular decarboxylation of the transported Asp catalyzed by an L-aspartate-[beta]-decarboxylase (AspD). AspT belongs to the newly classified aspartate:alanine exchanger family (transporter classification no. 2.A.81) of transporters. In this study, we were interested in the relationship between the structure and function of AspT and thus analyzed the topology by means of the substituted-cysteine accessibility method using the impermeant, fluorescent, thiol-specific probe Oregon Green 488 maleimide (OGM) and the impermeant, nonfluorescent, thiol-specific probe [2-(trimethylammonium)ethyl]methanethiosulfonate bromide. We generated 23 singlecysteine variants from a six-histidine-tagged cysteineless AspT template. A cysteine position was assigned an external location if the corresponding single-cysteine variant reacted with OGM added to intact cells, and a position was assigned an internal location if OGM labeling required cell lysis. The topology analyses revealed that AspT has a unique topology; the protein has 10 transmembrane helices (TMs), a large hydrophilic cytoplasmic loop (about 180 amino acids) between TM5 and TM6, N and C termini that face the periplasm, and a positively charged residue (arginine 76) within TM3. Moreover, the three-dimensional structure constructed by means of the full automatic modeling system indicates that the large hydrophilie cytoplasmic loop of AspT possesses a TrkA-C domain and a TrkA-C-like domain and that the three-dimensional structures of these domains are similar to each other even though their amino acid sequences show low similarity.

Published
2007

8. Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation

Author

Okada, Nobuhiko, Oi, Yorie, Takeda-Shitaka, Mayuko, Kanou, Kazuhiko, Umeyama, Hideaki, Haneda, Takeshi, Miki, Tsuyoshi, Hosoya, Sachiko, and Danbara, Hirofumi

Subjects
Salmonella -- Genetic aspects, Salmonella -- Physiological aspects, Gene mutations -- Research, DNA-ligand interactions -- Research, Genetic research, Biological sciences
Abstract

The type III secretion system encoded by Salmonella pathogenicity island 2 (SPI-2) is essential for the intracellular survival and replication of Salmonella enterica. The expression of SPI-2 genes is dependent on a two-component regulatory system, SsrA (SpiR)/SsrB, encoded in the SPI-2 region. This paper shows that SlyA regulates transcription of the sensor kinase SsrA by binding to the ssrA promoter, indicating that SlyA is directly involved in the regulation of SPI-2 gene expression. A structure model of the SlyA dimer in complex with DNA was constructed. The model of SlyA indicated that its structure is very similar to that of other MarR family proteins. Based on this model, site-directed mutagenesis of residues located in the winged-helix region required for DNA binding and in the x-helices of the N-terminal and C-terminal regions required for dimerization of the SlyA protein was performed to identify the residues that are critical for SlyA function. Nine mutants of SlyA with single substitutions were unable to activate ssrA transcription in vivo. These mutant SlyA proteins revealed that the residues Leu-63, Val-64, Arg-65, Leu-67, Leu-70, Arg-86 and Lys-88 within the winged-helix region are required for DNA binding, and residues Leu-12 and Leu-126 within the a-helices of the N-terminal and C-terminal regions are required for efficient dimer formation. A Salmonella slyA mutant strain carrying a plasmid expressing SlyA derivatives containing mutations at these amino acid positions did not exhibit restored SlyA function in infected HeLa cells, thereby confirming the structural and functional relationships of the SlyA protein.

Published
2007

9. Trends in CD4+ Cell Counts, Viral Load, Treatment, Testing History, and Sociodemographic Characteristics of Newly Diagnosed HIV Patients in Osaka, Japan, From 2003 through 2017: A Descriptive Study

Author

Kagiura, Fumiko, primary, Matsuyama, Ryota, additional, Watanabe, Dai, additional, Tsuchihashi, Yuuki, additional, Kanou, Kazuhiko, additional, Takahashi, Takuri, additional, Matsui, Yusuke, additional, Kakehashi, Masayuki, additional, Sunagawa, Tomimasa, additional, and Shirasaka, Takuma, additional

Published
2021
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12. Correlates of laboratory-confirmed measles in Japan, 2011–2015

Author

Watanabe, Aika, primary, Shimada, Tomoe, additional, Takahashi, Takuri, additional, Arima, Yuzo, additional, Kinoshita, Hitomi, additional, Saitoh, Takehiko, additional, Kanou, Kazuhiko, additional, Matsui, Tamano, additional, Sunagawa, Tomimasa, additional, Tanaka-Taya, Keiko, additional, and Oishi, Kazunori, additional

Published
2019
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15. Additional file 3: of Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitor

Author

Nojima, Hiroyuki, Kanou, Kazuhiko, Terashi, Genki, Takeda-Shitaka, Mayuko, Gaku Inoue, Atsuda, Koichiro, Itoh, Chihiro, Iguchi, Chie, and Matsubara, Hajime

Abstract

Figure S2. Superposition of some residues in ligand-free units. Eight ligand-free units are superimposed so that the RMSD targeting the main chain (the N, CÎą and C atoms) would be minimized based on a specific ligand-free unit. a Arg358, b Tyr547, c Ser630, d Ser209, e Val711 and f Asn710. (DOCX 124Â kb)

Published
2016
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16. Additional file 5: of Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitor

Author

Nojima, Hiroyuki, Kanou, Kazuhiko, Terashi, Genki, Takeda-Shitaka, Mayuko, Gaku Inoue, Atsuda, Koichiro, Itoh, Chihiro, Iguchi, Chie, and Matsubara, Hajime

Abstract

Figure S4. Superposition of two specific water O atoms in ligand-free units (yellow spheres). Six ligand-free units (1J2E_A, 1J2E_B, 1NU6_A, 1PFQ_A, 1TK3_A and 1TK3_B) that had one of the two specific water O atoms were superimposed so that CÎą atoms in DPP-4 (residue numbers 41â 764) would be minimized based on 1X70_A. The two specific water O atoms of the six ligand-free units (yellow spheres in the white broken circles) superimposed well onto those in 1X70_A with ligand (red spheres). (DOCX 329Â kb)

Published
2016
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18. Additional file 4: of Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitor

Author

Nojima, Hiroyuki, Kanou, Kazuhiko, Terashi, Genki, Takeda-Shitaka, Mayuko, Gaku Inoue, Atsuda, Koichiro, Itoh, Chihiro, Iguchi, Chie, and Matsubara, Hajime

Abstract

Figure S3. Superposition of two specific water O atoms in high temperature-measured units (yellow symbol “+”). The temperature-measured units were superimposed so that Cα atoms in DPP-4 (residue numbers 41–764) would be minimized based on 1X70_A (the two specific water O atoms of 1X70_A are marked by red symbol “+” in the white broken circles). The two specific water O atoms registered in the high temperature-measured units are superimposed well onto those in 1X70_A that was measured at low temperature (yellow symbol “+” in the white broken circles). (DOCX 273 kb)

Published
2016
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27. Nationwide rubella epidemic--Japan, 2013

Author

Tanaka-Taya, Keiko, Satoh, Hiroshi, Arai, Satoru, Yamagishi, Takuya, Yahata, Yuichiro, Nakashima, Kazutoshi, Sugawara, Tamie, Ohkusa, Yasushi, Matsui, Tamano, Saito, Takehito, Kanou, Kazuhiko, Shimada, Tomoe, Kinoshita, Hitomi, Yamashita, Kazuyo, Yasui, Yoshinori, Tada, Yuki, Mori, Yoshio, Takeda, Makoto, Sunagawa, Tomimasa, Oishi, Kazunori, Strebel, Peter, Schluter, W. William, Kamiya, Hajime, Reef, Susan E., Chu, Susan Y., and Martin, Rebecca

Subjects
Genetic disorders -- Prevention -- Health aspects, Measles-mumps-rubella vaccine -- Health aspects, Public health -- Health aspects, Vaccines -- Health aspects, Rubella -- Prevention -- Health aspects, Health, World Health Organization
Abstract

Rubella usually is a mild, febrile rash illness in children and adults; however, infection early in pregnancy, particularly during the first 16 weeks, can result in miscarriage, stillbirth, or an [...]

Published
2013

29. ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

Author

Miyakawa, Kei, primary, Matsunaga, Satoko, additional, Kanou, Kazuhiko, additional, Matsuzawa, Atsushi, additional, Morishita, Ryo, additional, Kudoh, Ayumi, additional, Shindo, Keisuke, additional, Yokoyama, Masaru, additional, Sato, Hironori, additional, Kimura, Hirokazu, additional, Tamura, Tomohiko, additional, Yamamoto, Naoki, additional, Ichijo, Hidenori, additional, Takaori-Kondo, Akifumi, additional, and Ryo, Akihide, additional

Published
2015
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30. Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment:meeting new challenges

Author

Kufareva, Irina, Katritch, Vsevolod, Biggin, Phil, Kim, Minsup, Park, Kichul, Jung, Sang Won, Cho, Art E., Sands, Zara A., Ostopovici-Halip, Liliana, Bologa, Cristian G., Norn, Christoffer, Brylinski, Michal, Skolnick, Jeffrey, Keränen, Henrik, Lenselink, Bart E., Van Westen, Gerard, Overington, John P., De Teráán, Hugo Gutiérrez, Isberg, Vignir, Fidom, Kimberley M., Lehto, Thomas M., Gloriam, David E., Ghosh, Anirban, Sonavane, Uddhavesh, Joshi, Rajendra, Xia, Jie, Hsieh, Jui Hua, Zhang, Liangren, Wang, Xiang Simon, Vogel, Horst, Yuan, Shuguang, Feng, X., Chen, M., Ambia, J., Barth, P., Gageat, Cédric, Stepniewski, Michal, Xhaard, Henri, Kelm, Sebastian, Pitt, William R., Shi, Jiye, Larsen, Adrien, Li, Hubert, Wagner, Jeffrey, Bhattacharya, Supriyo, Vaidehi, Nagarajan, Kanou, Kazuhiko, Cvicek, Vaclav, Kim, Soo Kyung, Trzaskowski, Bartosz, Goddard, William A., Abrol, Ravinder, Selvam, Balaji, Tikhonova, Irina G., Cuzzolin, Alberto, Sabbadin, Davide, Ciancetta, Antonella, Moro, Stefano, Freyd, Thibaud, Gabrielsen, Mari, Kristiansen, Kurt, Sylte, Ingebrigt, Gaffney, Kevin J., Petasis, Nicos A., Latek, Dorota, Bajda, Marek, Młynarczyk, Krzysztof, Filipek, Sławomir, López, Laura, Kuiper, Michael, Beuming, Thijs, Perez-Aguilar, Jose Manuel, Wang, Ray Yu Ruei, Park, Hahnbeom, Greisen, Per, Song, Yifan, DiMaio, Frank, Baker, David, Shin, Woong Hee, Heo, Lim, Lee, Gyu Rie, Seok, Chaok, Yang, Jianyi, Zhang, Yang, Ponassi, Marco, Rosano, Camillo, Cheremovskiy, Georgy, Grudinin, Sergei, Chaudhari, Rajan, Heim, Andrew J., Li, Zhijun, Lv, Qiang, Grigorov, Martin G., Hu, Xin, Sun, Hongmao, Shen, Min, Southall, Noel, Jadhav, Ajit, Rodríguez, David, Ranganathan, Anirudh, Carlsson, Jens, Najmanovich, Rafael, Durdagi, Serdar, De March, Claire, Diharce, Julien, Golebiowski, Jérôme, Antonczak, Serge, Fiorucci, Sébastien, Nguyen, Elizabeth, Meiler, Jens, Gutcaits, Aleksandrs, Marti-Solano, Maria, Pastor, Manuel, Selent, Jana, Stevens, Raymond C., Abagyan, Ruben, Kufareva, Irina, Katritch, Vsevolod, Biggin, Phil, Kim, Minsup, Park, Kichul, Jung, Sang Won, Cho, Art E., Sands, Zara A., Ostopovici-Halip, Liliana, Bologa, Cristian G., Norn, Christoffer, Brylinski, Michal, Skolnick, Jeffrey, Keränen, Henrik, Lenselink, Bart E., Van Westen, Gerard, Overington, John P., De Teráán, Hugo Gutiérrez, Isberg, Vignir, Fidom, Kimberley M., Lehto, Thomas M., Gloriam, David E., Ghosh, Anirban, Sonavane, Uddhavesh, Joshi, Rajendra, Xia, Jie, Hsieh, Jui Hua, Zhang, Liangren, Wang, Xiang Simon, Vogel, Horst, Yuan, Shuguang, Feng, X., Chen, M., Ambia, J., Barth, P., Gageat, Cédric, Stepniewski, Michal, Xhaard, Henri, Kelm, Sebastian, Pitt, William R., Shi, Jiye, Larsen, Adrien, Li, Hubert, Wagner, Jeffrey, Bhattacharya, Supriyo, Vaidehi, Nagarajan, Kanou, Kazuhiko, Cvicek, Vaclav, Kim, Soo Kyung, Trzaskowski, Bartosz, Goddard, William A., Abrol, Ravinder, Selvam, Balaji, Tikhonova, Irina G., Cuzzolin, Alberto, Sabbadin, Davide, Ciancetta, Antonella, Moro, Stefano, Freyd, Thibaud, Gabrielsen, Mari, Kristiansen, Kurt, Sylte, Ingebrigt, Gaffney, Kevin J., Petasis, Nicos A., Latek, Dorota, Bajda, Marek, Młynarczyk, Krzysztof, Filipek, Sławomir, López, Laura, Kuiper, Michael, Beuming, Thijs, Perez-Aguilar, Jose Manuel, Wang, Ray Yu Ruei, Park, Hahnbeom, Greisen, Per, Song, Yifan, DiMaio, Frank, Baker, David, Shin, Woong Hee, Heo, Lim, Lee, Gyu Rie, Seok, Chaok, Yang, Jianyi, Zhang, Yang, Ponassi, Marco, Rosano, Camillo, Cheremovskiy, Georgy, Grudinin, Sergei, Chaudhari, Rajan, Heim, Andrew J., Li, Zhijun, Lv, Qiang, Grigorov, Martin G., Hu, Xin, Sun, Hongmao, Shen, Min, Southall, Noel, Jadhav, Ajit, Rodríguez, David, Ranganathan, Anirudh, Carlsson, Jens, Najmanovich, Rafael, Durdagi, Serdar, De March, Claire, Diharce, Julien, Golebiowski, Jérôme, Antonczak, Serge, Fiorucci, Sébastien, Nguyen, Elizabeth, Meiler, Jens, Gutcaits, Aleksandrs, Marti-Solano, Maria, Pastor, Manuel, Selent, Jana, Stevens, Raymond C., and Abagyan, Ruben

Abstract

Despite tremendous successes of GPCR crystallography, the receptors with available structures represent only a small fraction of human GPCRs. An important role of the modeling community is to maximize structural insights for the remaining receptors and complexes. The community-wide GPCR Dock assessment was established to stimulate and monitor the progress in molecular modeling and ligand docking for GPCRs. The four targets in the present third assessment round presented new and diverse challenges for modelers, including prediction of allosteric ligand interaction and activation states in 5-hydroxytryptamine receptors 1B and 2B, and modeling by extremely distant homology for smoothened receptor. Forty-four modeling groups participated in the assessment. State-of-the-art modeling approaches achieved close-to-experimental accuracy for small rigid orthosteric ligands and models built by close homology, and they correctly predicted protein fold for distant homology targets. Predictions of long loops and GPCR activation states remain unsolved problems.

Published
2014

31. Ongoing increase in measles cases following importations, Japan, March 2014: times of challenge and opportunity

Author

Takahashi, Takuri, primary, Arima, Yuzo, additional, Kinoshita, Hitomi, additional, Kanou, Kazuhiko, additional, Saitoh, Takehito, additional, Sunagawa, Tomimasa, additional, Ito, Hiroaki, additional, Kanayama, Atsuhiro, additional, Tabuchi, Ayako, additional, Nakashima, Kazutoshi, additional, Yahata, Yuichiro, additional, Yamagishi, Takuya, additional, Sugawara, Tamie, additional, Ohkusa, Yasushi, additional, Matsui, Tamano, additional, Arai, Satoru, additional, Satoh, Hiroshi, additional, Tanaka-Taya, Keiko, additional, Komase, Katsuhiro, additional, Takeda, Makoto, additional, and Oishi, Kazunori, additional

Published
2014
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32. The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses

Author

Sakai, Kouji, primary, Ami, Yasushi, additional, Tahara, Maino, additional, Kubota, Toru, additional, Anraku, Masaki, additional, Abe, Masako, additional, Nakajima, Noriko, additional, Sekizuka, Tsuyoshi, additional, Shirato, Kazuya, additional, Suzaki, Yuriko, additional, Ainai, Akira, additional, Nakatsu, Yuichiro, additional, Kanou, Kazuhiko, additional, Nakamura, Kazuya, additional, Suzuki, Tadaki, additional, Komase, Katsuhiro, additional, Nobusawa, Eri, additional, Maenaka, Katsumi, additional, Kuroda, Makoto, additional, Hasegawa, Hideki, additional, Kawaoka, Yoshihiro, additional, Tashiro, Masato, additional, and Takeda, Makoto, additional

Published
2014
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33. TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses

Author

Abe, Masako, primary, Tahara, Maino, additional, Sakai, Kouji, additional, Yamaguchi, Hiromi, additional, Kanou, Kazuhiko, additional, Shirato, Kazuya, additional, Kawase, Miyuki, additional, Noda, Masahiro, additional, Kimura, Hirokazu, additional, Matsuyama, Shutoku, additional, Fukuhara, Hideo, additional, Mizuta, Katsumi, additional, Maenaka, Katsumi, additional, Ami, Yasushi, additional, Esumi, Mariko, additional, Kato, Atsushi, additional, and Takeda, Makoto, additional

Published
2013
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34. Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan 2008–2011

Author

Kushibuchi, Izumi, primary, Kobayashi, Miho, additional, Kusaka, Takashi, additional, Tsukagoshi, Hiroyuki, additional, Ryo, Akihide, additional, Yoshida, Ayako, additional, Ishii, Haruyuki, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Yamamoto, Norio, additional, Kanou, Kazuhiko, additional, Saitoh, Mika, additional, Noda, Masahiro, additional, Kuroda, Makoto, additional, Morita, Yukio, additional, Kozawa, Kunihisa, additional, Oishi, Kazunori, additional, Tashiro, Masato, additional, and Kimura, Hirokazu, additional

Published
2013
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35. A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit

Author

Yasui, Yoshinori, primary, Makino, Tomohiko, additional, Hanaoka, Nozomu, additional, Owa, Kenji, additional, Horikoshi, Atsuko, additional, Tanaka, Atsuo, additional, Suehiro, Yutaka, additional, Shimizu, Hiroyuki, additional, Kanou, Kazuhiko, additional, Kobayashi, Masaaki, additional, Konagaya, Masami, additional, and Fujimoto, Tsuguto, additional

Published
2013
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47. Enterohemorrhagic Escherichia coli outbreaks related to childcare facilities in Japan, 2010-2013.

Author

Atsuhiro Kanayama, Yuichiro Yahata, Yuzo Arima, Takuri Takahashi, Takehito Saitoh, Kazuhiko Kanou, Kunio Kawabata, Tomimasa Sunagawa, Tamano Matsui, Kazunori Oishi, Kanayama, Atsuhiro, Yahata, Yuichiro, Arima, Yuzo, Takahashi, Takuri, Saitoh, Takehito, Kanou, Kazuhiko, Kawabata, Kunio, Sunagawa, Tomimasa, Matsui, Tamano, and Oishi, Kazunori

Subjects
ESCHERICHIA coli O157:H7, DISEASE outbreaks, DAY care centers, PUBLIC health surveillance, HAND washing, GASTROENTERITIS, CHILD care, ESCHERICHIA coli, ESCHERICHIA coli diseases, FECES, SEROTYPES, DESCRIPTIVE statistics
Abstract

Background: Enterohemorrhagic Escherichia coli (EHEC) is an important cause of gastroenteritis in Japan. Although non-O157 EHEC infections have been increasingly reported worldwide, their impact on children has not been well described.Methods: We collected national surveillance data of EHEC infections reported between 2010 and 2013 in Japan and characterized outbreaks that occurred in childcare facilities. Per Japanese outbreak investigation protocol, faecal samples from contacts of EHEC cases were collected regardless of symptomatic status. Cases and outbreaks were described by demographics, dates of diagnosis and onset, clinical manifestations, laboratory data, and relation to specific outbreaks in childcare facilities.Results: During 2010-2013, a total of 68 EHEC outbreaks comprised of 1035 cases were related to childcare facilities. Among the 66 outbreaks caused by a single serogroup, 29 were serogroup O26 and 22 were O157; 35 outbreaks were caused by stx1-producing strains. Since 2010, the number of reported outbreaks steadily increased, with a rise in cases and outbreaks caused by stx1-producing O26. Of 7069 EHEC cases reported nationally in 2010-2011, the majority were caused by O157 (n = 4938), relative to O26 (n = 1353) and O111 (n = 195). However, relative to 69 cases of O157 (2%) associated with childcare facility EHEC outbreaks, there were 131 (10%) such cases of O26, and this trend intensified in 2012-2013 (O157, 3%; O26, 24%; O111, 48%). Among family members of childcare facility cases, the proportion of cases that were symptomatic declined with age; 10/16 cases (63%) aged 6 years or younger, 16/53 cases (30%) 6-19 years old, 23/120 cases (19%) 20-49 years old and 2/28 cases (7%) 50 years or older were symptomatic. Thirty one of the 68 outbreaks (46%) were classified as foodborne-related.Conclusions: Childcare facility EHEC outbreaks due to non-O157 serogroups, particularly O26 and O111, increased during 2010-2013. These facilities should pay extra attention to health conditions in children. As older family members of childcare facility cases appear to be less symptomatic, they should be vigilant about hand-washing to prevent further transmission. [ABSTRACT FROM AUTHOR]

Published
2015
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50. Fams-ace: A combined method to select the best model after remodeling all server models.

Author

Terashi, Genki, Takeda-Shitaka, Mayuko, Kanou, Kazuhiko, Iwadate, Mitsuo, Takaya, Daisuke, Hosoi, Akio, Ohta, Kazuhiro, and Umeyama, Hideaki

Abstract

During Critical Assessment of Protein Structure Prediction (CASP7, Pacific Grove, CA, 2006), fams-ace was entered in the 3D coordinate prediction category as a human expert group. The procedure can be summarized by the following three steps. (1) All the server models were refined and rebuilt utilizing our homology modeling method. (2) Representative structures were selected from each server, according to a model quality evaluation, based on a 3D1D profile score (like Verify3D). (3) The top five models were selected and submitted in the order of the consensus-based score (like 3D-Jury). Fams-ace is a fully automated server and does not require human intervention. In this article, we introduce the methodology of fams-ace and discuss the successes and failures of this approach during CASP7. In addition, we discuss possible improvements for the next CASP. Proteins 2007. © 2007 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2007
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