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Aim: Cerium oxide, particularly in nanoparticle form (nanoceria), has been investigated for biomedical applications as a promising new agent for treating several pathologies. The aim of the present study was to characterize the pharmacologic effects of nanoceria in an animal model of chronic kidney disease. Methods: We created the chronic kidney disease animal model by feeding rats a 0.25% adenine diet. Male Wistar rats were divided into five groups: normal diet, 0.25% adenine diet, or adenine diet containing three different doses or durations of nanoceria treatment. Blood was collected weekly from the tail veins of each rat and analyzed for renal function markers. After 5 weeks, various biochemical markers in serum, plasma, and urine were also analyzed. Results: In the adenine‐treated group, body weight was significantly decreased, and the kidneys lost much of their healthy reddish color and became lumpy and white in appearance. In addition, levels of serum creatinine, blood urea nitrogen, and plasma uremic toxins were significantly increased in adenine‐treated rats compared with controls. Renal functional and structural damage in adenine diet model rats tended to be ameliorated by nanoceria ingestion. The high‐dose cerium‐treated group maintained reddish areas in the kidneys, and the increases in biomarker levels of creatinine, blood urea nitrogen, and inorganic phosphorus were markedly reduced, regardless of treatment duration. Conclusions: Ingestion of nanoceria may be effective for improving or preventing renal damage caused by adenine. Geriatr Gerontol Int 2024; 24: 88–95. [ABSTRACT FROM AUTHOR]

Accumulation of oxidative damage increases the risk of several disorders. To prevent these diseases, people consume supplements. However, there is little evidence of the impact of supplement intake on cognitive function. Recently, frailty and sarcopenia have become serious issues, and these phenomena include a risk of mild cognitive impairment. In this study, aged mice were fed the combination supplement and cognitive and motor functions were measured. Following 1 month of treatment with the supplement, significant improvements in cognitive function and neuromuscular coordination were observed. Following 2 weeks of treadmill training, treatment with the supplement dramatically increased running distance compared to that in untreated normal aged mice. Serum indices such as triglyceride and total cholesterol were significantly decreased in the supplement-treated aged mice compared to untreated aged mice. These results indicate that the combination supplement may play a role in maintaining cognitive function, coordination ability and improving lipid metabolism., Competing Interests: FY, YH, and HI are employees of Gifu University. The Division of Anti-oxidant Research is a laboratory that has been established in the Life Science Research Center, Gifu University based on a research fund from the TIMA establishment. A product is sold by the TIMA Tokyo Inc. under the name of TwM as a product with a similar formulation, but it is different from the one used in this experiment. The TwM used in the experiment was not the commercially available product itself, but one produce by Gifu University. FY, YH, and HI receive payment for consultation or expert testimony provided to, and do not have stock or stock options from, TIMA Group. Some author photos are posted on the homepage. But they haven’t received all the payments. TY is a developer of TwM un collaboration with the TIMA Foundation and TIMA Tokyo Inc. The sponsor had no control over the interpretation, writing, or publication of this work. The other authors declare that they have no conflicts of interest to disclose., (Copyright © 2024 JCBN.)