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1. Sparse Regression Codes for Non-Coherent SIMO channels

Author

Kancharana, Sai Dinesh, Sinha, Madhusudan Kumar, and Kannu, Arun Pachai

Subjects
Electrical Engineering and Systems Science - Signal Processing, Computer Science - Information Theory
Abstract

We study the sparse regression codes over flat-fading channels with multiple receive antennas. We consider a practical scenario where the channel state information is not available at the transmitter and the receiver. In this setting, we study the maximum likelihood (ML) detector for SPARC, which has a prohibitively high search complexity. We propose a novel practical decoder, named maximum likelihood matching pursuit (MLMP), which incorporates a greedy search mechanism along with the ML metric. We also introduce a parallel search mechanism for MLMP. Comparing with the existing block-orthogonal matching pursuit based decoders, we show that MLMP has significant gains in the block error rate (BLER) performance. We also show that the proposed approach has significant gains over polar codes employing pilot-aided channel estimation.

Published
2024

2. Acute Urticaria in Children in a Tertiary Care Hospital: A Cross-sectional Study

Author

KANNU PRIYA and Anupama Vinayak Mauskar

Subjects
angioedema, itching, viral infections, Medicine
Abstract

Introduction: Urticaria is a highly prevalent condition resulting in a large number of medical consultancies worldwide. Urticaria is derived from the Latin word “urere” meaning “to burn”. Urticaria usually manifests as a transient, itchy, polymorphic skin eruption. It can occur in any age group. Aim: A study was undertaken to find out the prevalence and possible triggers of acute urticaria in children. Materials and Methods: All children of age group six months to 12 years visiting the Institute from June 2018 to April 2019, with the complaint of acute urticaria with or without angioedema were included in the study while those with chronic urticaria and only angioedema were excluded. Sixty five children presented with acute urticaria with or without angioedema. Patients were diagnosed based on history and clinical examination. All patients were subjected to a detailed history, general physical examination and, necessary investigations like Complete Blood Count (CBC), Absolute Eosinophil count, Erythrocyte Sedimentation Rate (ESR), C-reactive Protein (CRP), Skin Prick test as indicated. They received appropriate treatment and their clinical outcome was studied. Results: Prevalence of acute urticaria was found to be 0.23. It was more commonly seen in males (63.08%) and more in the age group of 1 to 5 years (56.92%). The focus of infection was found in 44.6% of children, while 21% of children had a history of consumption of some form of medications leading to urticaria. Conclusion: Urticaria can be prevented in children by preventing them from infection and avoiding the use of amoxicillin-clavulanic acid unless very necessary. Those children with a family history of acute urticaria should be prevented from exposure to excessive heat, cold, pressure, vibration, etc. Investigations are also recommended as an important diagnostic tool to find out the aetiology of acute urticaria.

Published
2021
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5. Influenza A Virus Infection Activates NLRP3 Inflammasome through Trans-Golgi Network Dispersion

Author

Kannu Priya Pandey and Yan Zhou

Subjects
influenza A virus, NLRP3 inflammasome, trans-Golgi network, M2 ion channel protein, Microbiology, QR1-502
Abstract

The NLRP3 inflammasome consists of NLRP3, ASC, and pro-caspase-1 and is an important arm of the innate immune response against influenza A virus (IAV) infection. Upon infection, the inflammasome is activated, resulting in the production of IL-1β and IL-18, which recruits other immune cells to the site of infection. It has been suggested that in the presence of stress molecules such as nigericin, the trans-Golgi network (TGN) disperses into small puncta-like structures where NLRP3 is recruited and activated. Here, we investigated whether IAV infection could lead to TGN dispersion, whether dispersed TGN (dTGN) is responsible for NLRP3 inflammasome activation, and which viral protein is involved in this process. We showed that the IAV causes dTGN formation, which serves as one of the mechanisms of NLRP3 inflammasome activation in response to IAV infection. Furthermore, we generated a series of mutant IAVs that carry mutations in the M2 protein. We demonstrated the M2 proton channel activity, specifically His37 and Trp41 are pivotal for the dispersion of TGN, NLRP3 conformational change, and IL-1β induction. The results revealed a novel mechanism behind the activation and regulation of the NLRP3 inflammasome in IAV infection.

Published
2022
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6. Momentousness of denture labeling using Aadhaar number in Indian population

Author

Neha Sikka, Sameer Saxena, Kannu Priya, and Vanita Suthar

Subjects
Aadhaar, denture labeling, surface marking, Medicine
Abstract

Personal identification is of prime importance for forensic and medicolegal purposes especially in case of natural calamities, accidents, state of unconsciousness, or loss of memory. The denture labeling is an important method which has been acknowledged by the field of dentistry. Various denture labeling techniques have been advocated but none of them is universal. Aadhaar is the instantly verifiable national identification number assigned to residents of India, which is currently being used vastly by the Government of India. The article describes a simple, economical, and permanent method for inclusion of Unique Identification Number and bar code in dentures.

Published
2019
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7. Generalized Sparse Regression Codes for Short Block Lengths

Author

Sinha, Madhusudan Kumar and Kannu, Arun Pachai

Subjects
Computer Science - Information Theory, Electrical Engineering and Systems Science - Signal Processing
Abstract

Sparse regression codes (SPARC) connect the sparse signal recovery framework of compressive sensing with error control coding techniques. SPARC encoding produces codewords which are \emph{sparse} linear combinations of columns of a dictionary matrix. SPARC decoding is accomplished using sparse signal recovery algorithms. We construct dictionary matrices using Gold codes and mutually unbiased bases and develop suitable generalizations of SPARC (GSPARC). We develop a greedy decoder, referred as match and decode (MAD) algorithm and provide its analytical noiseless recovery guarantees. We propose a parallel greedy search technique, referred as parallel MAD (PMAD), to improve the performance. We describe the applicability of GSPARC with PMAD decoder for multi-user channels, providing a non-orthogonal multiple access scheme. We present numerical results comparing the block error rate (BLER) performance of the proposed algorithms for GSPARC in AWGN channels, in the short block length regime. The PMAD decoder gives better BLER than the approximate message passing decoder for SPARC. GSPARC with PMAD gives comparable and competitive BLER performance, when compared to other existing codes. In multi-user channels, GSPARC with PMAD decoder outperforms the sphere packing lower bounds of an orthogonal multiple access scheme, which has the same spectral efficiency., Comment: arXiv admin note: text overlap with arXiv:2102.03489

Published
2023

10. Infigratinib in children with achondroplasia: the PROPEL and PROPEL 2 studies

Author

Savarirayan, Ravi, De Bergua, Josep Maria, Arundel, Paul, McDevitt, Helen, Cormier-Daire, Valerie, Saraff, Vrinda, Skae, Mars, Delgado, Borja, Leiva-Gea, Antonio, Santos-Simarro, Fernando, Salles, Jean Pierre, Nicolino, Marc, Rossi, Massimiliano, Kannu, Peter, Bober, Michael B, Phillips, John, Saal, Howard, Harmatz, Paul, Burren, Christine, Gotway, Garrett, Cho, Terry, Muslimova, Elena, Weng, Richard, Rogoff, Daniela, Hoover-Fong, Julie, and Irving, Melita

Subjects
Pediatric, Clinical Research, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, achondroplasia, clinical trial, fibroblast growth factor receptor 3, infigratinib, Clinical Sciences
Abstract

BackgroundAchondroplasia is the most common short-limbed skeletal dysplasia resulting from gain-of-function pathogenic variants in fibroblast growth factor receptor 3 (FGFR3) gene, a negative regulator of endochondral bone formation. Most treatment options are symptomatic, targeting medical complications. Infigratinib is an orally bioavailable, FGFR1-3 selective tyrosine kinase inhibitor being investigated as a direct therapeutic strategy to counteract FGFR3 overactivity in achondroplasia.ObjectivesThe main objective of PROPEL is to collect baseline data of children with achondroplasia being considered for future enrollment in interventional studies sponsored by QED Therapeutics. The objectives of PROPEL 2 are to obtain preliminary evidence of safety and efficacy of oral infigratinib in children with achondroplasia, to identify the infigratinib dose to be explored in future studies, and to characterize the pharmacokinetic (PK) profile of infigratinib and major metabolites.DesignPROPEL (NCT04035811) is a prospective, noninterventional clinical study designed to characterize the natural history and collect baseline data of children with achondroplasia over 6-24 months. PROPEL 2 (NCT04265651), a prospective, phase II, open-label study of infigratinib in children with achondroplasia, consists of a dose-escalation, dose-finding, and dose-expansion phase to confirm the selected dose, and a PK substudy.Methods and analysisChildren aged 3-11 years with achondroplasia who completed ⩾6 months in PROPEL are eligible for PROPEL 2. Primary endpoints include treatment-emergent adverse events and change from baseline in annualized height velocity. Four cohorts at ascending dose levels are planned for dose escalation. The selected dose will be confirmed in the dose-expansion phase.EthicsPROPEL and PROPEL 2 are being conducted in accordance with the International Conference on Harmonization Good Clinical Practice guidelines, principles of the Declaration of Helsinki, and relevant human clinical research and data privacy regulations. Protocols have been approved by local health authorities, ethics committees, and institutions as applicable. Parents/legally authorized representatives are required to provide signed informed consent; signed informed assent by the child is also required, where applicable.DiscussionPROPEL and PROPEL 2 will provide preliminary evidence of the safety and efficacy of infigratinib as precision treatment of children with achondroplasia and will inform the design of future studies of FGFR-targeted agents in achondroplasia.RegistrationClinicalTrials.gov: NCT04035811; NCT04265651.

Published
2022

11. Communications using Sparse Signals

Author

Sinha, Madhusudan Kumar and Kannu, Arun Pachai

Subjects
Computer Science - Information Theory, Electrical Engineering and Systems Science - Signal Processing
Abstract

Inspired by compressive sensing principles, we propose novel error control coding techniques for communication systems. The information bits are encoded in the support and the non-zero entries of a sparse signal. By selecting a dictionary matrix with suitable dimensions, the codeword for transmission is obtained by multiplying the dictionary matrix with the sparse signal. Specifically, the codewords are obtained from the sparse linear combinations of the columns of the dictionary matrix. At the decoder, we employ variations of greedy sparse signal recovery algorithms. Using Gold code sequences and mutually unbiased bases from quantum information theory as dictionary matrices, we study the block error rate (BLER) performance of the proposed scheme in the AWGN channel. Our results show that the proposed scheme has a comparable and competitive performance with respect to the several widely used linear codes, for very small to moderate block lengths. In addition, our coding scheme extends straightforwardly to multi-user scenarios such as multiple access channel, broadcast channel, and interference channel. In these multi-user channels, if the users are grouped such that they have similar channel gains and noise levels, the overall BLER performance of our proposed scheme will coincide with an equivalent single-user scenario., Comment: 11 pages, 8 figures

Published
2021

12. Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature

Author

Rots, Dmitrijs, Chater-Diehl, Eric, Dingemans, Alexander JM, Goodman, Sarah J, Siu, Michelle T, Cytrynbaum, Cheryl, Choufani, Sanaa, Hoang, Ny, Walker, Susan, Awamleh, Zain, Charkow, Joshua, Meyn, Stephen, Pfundt, Rolph, Rinne, Tuula, Gardeitchik, Thatjana, de Vries, Bert BA, Deden, A Chantal, Leenders, Erika, Kwint, Michael, Stumpel, Constance TRM, Stevens, Servi JC, Vermeulen, Jeroen R, van Harssel, Jeske VT, Bosch, Danielle GM, van Gassen, Koen LI, van Binsbergen, Ellen, de Geus, Christa M, Brackel, Hein, Hempel, Maja, Lessel, Davor, Denecke, Jonas, Slavotinek, Anne, Strober, Jonathan, Crunk, Amy, Folk, Leandra, Wentzensen, Ingrid M, Yang, Hui, Zou, Fanggeng, Millan, Francisca, Person, Richard, Xie, Yili, Liu, Shuxi, Ousager, Lilian B, Larsen, Martin, Schultz-Rogers, Laura, Morava, Eva, Klee, Eric W, Berry, Ian R, Campbell, Jennifer, Lindstrom, Kristin, Pruniski, Brianna, Neumeyer, Ann M, Radley, Jessica A, Phornphutkul, Chanika, Schmidt, Berkley, Wilson, William G, Õunap, Katrin, Reinson, Karit, Pajusalu, Sander, van Haeringen, Arie, Ruivenkamp, Claudia, Cuperus, Roos, Santos-Simarro, Fernando, Palomares-Bralo, María, Pacio-Míguez, Marta, Ritter, Alyssa, Bhoj, Elizabeth, Tønne, Elin, Tveten, Kristian, Cappuccio, Gerarda, Brunetti-Pierri, Nicola, Rowe, Leah, Bunn, Jason, Saenz, Margarita, Platzer, Konrad, Mertens, Mareike, Caluseriu, Oana, Nowaczyk, Małgorzata JM, Cohn, Ronald D, Kannu, Peter, Alkhunaizi, Ebba, Chitayat, David, Scherer, Stephen W, Brunner, Han G, Vissers, Lisenka ELM, Kleefstra, Tjitske, Koolen, David A, and Weksberg, Rosanna

Subjects
Genetics, Clinical Research, Brain Disorders, Mental Health, Intellectual and Developmental Disabilities (IDD), Aetiology, 2.1 Biological and endogenous factors, Abnormalities, Multiple, Adenosine Triphosphatases, Case-Control Studies, Cohort Studies, Craniofacial Abnormalities, DNA Methylation, Epigenesis, Genetic, Female, Genetic Predisposition to Disease, Growth Disorders, Heart Septal Defects, Ventricular, Humans, Infant, Newborn, Male, Mutation, Neurodevelopmental Disorders, Phenotype, DNA methylation signature, Floating-Harbor syndrome, SRCAP, epigenomics, genotype-phenotype correlation, intellectual disability, neurodevelopmental disorders, non-FLHS SRCAP-related NDD, nonsense-mediated decay, speech delay, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Truncating variants in exons 33 and 34 of the SNF2-related CREBBP activator protein (SRCAP) gene cause the neurodevelopmental disorder (NDD) Floating-Harbor syndrome (FLHS), characterized by short stature, speech delay, and facial dysmorphism. Here, we present a cohort of 33 individuals with clinical features distinct from FLHS and truncating (mostly de novo) SRCAP variants either proximal (n = 28) or distal (n = 5) to the FLHS locus. Detailed clinical characterization of the proximal SRCAP individuals identified shared characteristics: developmental delay with or without intellectual disability, behavioral and psychiatric problems, non-specific facial features, musculoskeletal issues, and hypotonia. Because FLHS is known to be associated with a unique set of DNA methylation (DNAm) changes in blood, a DNAm signature, we investigated whether there was a distinct signature associated with our affected individuals. A machine-learning model, based on the FLHS DNAm signature, negatively classified all our tested subjects. Comparing proximal variants with typically developing controls, we identified a DNAm signature distinct from the FLHS signature. Based on the DNAm and clinical data, we refer to the condition as "non-FLHS SRCAP-related NDD." All five distal variants classified negatively using the FLHS DNAm model while two classified positively using the proximal model. This suggests divergent pathogenicity of these variants, though clinically the distal group presented with NDD, similar to the proximal SRCAP group. In summary, for SRCAP, there is a clear relationship between variant location, DNAm profile, and clinical phenotype. These results highlight the power of combined epigenetic, molecular, and clinical studies to identify and characterize genotype-epigenotype-phenotype correlations.

Published
2021

13. TRPV4 related skeletal dysplasias: a phenotypic spectrum highlighted byclinical, radiographic, and molecular studies in 21 new families

Author

Sillence David, Patricelli Maria G, Gardner RJ McKinlay, McGillivray George, Kerr Bronwyn, Kannu Peter, Hunter Warwick, Haan Eric, Alcausin Melanie, Aftimos Salim, Andreucci Elena, Thompson Elizabeth, Zacharin Margaret, Zankl Andreas, Lamandé Shireen R, and Savarirayan Ravi

Subjects
TRPV4, Metatropic Dysplasia (MD), Autosomal Dominant Brachyolmia (ADBO), Spondilometaphyseal Dysplasia Kozlowski Type (SMDK), Medicine
Abstract

Abstract Background The TRPV4 gene encodes a calcium-permeable ion-channel that is widely expressed, responds to many different stimuli and participates in an extraordinarily wide range of physiologic processes. Autosomal dominant brachyolmia, spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MD) are currently considered three distinct skeletal dysplasias with some shared clinical features, including short stature, platyspondyly, and progressive scoliosis. Recently, TRPV4 mutations have been found in patients diagnosed with these skeletal phenotypes. Methods and Results We critically analysed the clinical and radiographic data on 26 subjects from 21 families, all of whom had a clinical diagnosis of one of the conditions described above: 15 with MD; 9 with SMDK; and 2 with brachyolmia. We sequenced TRPV4 and identified 9 different mutations in 22 patients, 4 previously described, and 5 novel. There were 4 mutation-negative cases: one with MD and one with SMDK, both displaying atypical clinical and radiographic features for these diagnoses; and two with brachyolmia, who had isolated spine changes and no metaphyseal involvement. Conclusions Our data suggest the TRPV4 skeletal dysplasias represent a continuum of severity with areas of phenotypic overlap, even within the same family. We propose that AD brachyolmia lies at the mildest end of this spectrum and, since all cases described with this diagnosis and TRPV4 mutations display metaphyseal changes, we suggest that it is not a distinct entity but represents the mildest phenotypic expression of SMDK.

Published
2011
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14. 3-D Beamforming Training Using Mutually Unbiased Bases for Cell Discovery in mm-Wave Systems

Author

P. Rashmi, A. Manoj, and Arun Pachai Kannu

Subjects
Initial access, cell discovery, beamforming training, compressive sensing, mutually unbiased bases, mutual coherence, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Beamforming training or cell discovery (CD) is a fundamental procedure in millimeter wave communication systems in which the user detects the presence of a base station, acquires the identity of that base station, and finds suitable beamforming directions to establish the wireless link for the subsequent data transmission phase. We consider uniform planar array-based beamforming under both separable and non-separable configurations as it allows confined antenna placements and 3-D steering of beams. Our focus is to design the beamforming training phase and develop low-complexity receiver algorithms for the cell discovery procedure. By exploiting the sparse nature of the mm-wave channels and using an equivalent compressive sensing measurement model, we obtain analytical bounds for the cell detection probability in terms of the mutual coherence parameter of the resulting sensing matrix. Using mutually unbiased bases (MUB) from quantum information theory, we design CD schemes with low mutual coherence. Our design includes parameters that control the training phase duration, and we analytically characterize the relationship between the training duration and the corresponding mutual coherence value. We present detailed simulation studies using experimentally driven mm-wave channel simulators and show that our MUB based scheme gives superior detection performance when compared to the conventional beam sweeping based schemes and random beamforming schemes.

Published
2023
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15. Analysis of Beam Sweeping Techniques for Cell-Discovery in mm Wave Systems

Author

P, Rashmi, A, Manoj, and Kannu, Arun Pachai

Subjects
Electrical Engineering and Systems Science - Signal Processing, Computer Science - Information Theory
Abstract

Cell discovery is the procedure in which a user equipment (UE) finds a suitable base station (BS) to establish a communication link. When beamforming with antenna arrays is done at both transmitter and receiver, cell discovery in mm wave systems also involves finding the correct angle of arrival - angle of departure alignment between the UE and the detected BS. First, we consider the single BS scenario and present the mathematical model for the cell discovery problem. We present the details of the beam sweeping based techniques and explain the beam combining scheme to reduce the training overhead. We analytically characterize the performance of energy detector at the UE for both beam sweeping and beam combining methods under some channel assumptions. Further, we consider the multiple BS case where BSs transmit synchronization signals along with directional beamforming. We analyze the performance of the energy detector in this case as well. We finally present simulation studies with channels generated using generic mm wave channel emulators and draw inferences on the role of various parameters on the cell discovery performance.

Published
2019

16. Change Detection with Sparse Signals using Quantum Designs

Author

Jain, Aditi, Sarvepalli, Pradeep, Bhashyam, Srikrishna, and Kannu, Arun Pachai

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

We consider the change detection problem where the pre-change observation vectors are purely noise and the post-change observation vectors are noise-corrupted compressive measurements of sparse signals with a common support, measured using a sensing matrix. In general, post-change distribution of the observations depends on parameters such as the support and variances of the sparse signal. When these parameters are unknown, we propose two approaches. In the first approach, we approximate the post-change pdf based on the known parameters such as mutual coherence of the sensing matrix and bounds on the signal variances. In the second approach, we parameterize the post-change pdf with an unknown parameter and try to adaptively estimate this parameter using a stochastic gradient descent method. In both these approaches, we employ CUSUM algorithm with various decision statistics such as the energy of the observations, correlation values with columns of the sensing matrix and the maximum value of such correlations. We study the performance of these approaches and offer insights on the relevance of different decision statistics in different SNR regimes. We also address the problem of designing sensing matrices with small coherence by using designs from quantum information theory. One such design, called SIC POVM, also has an additional structure which allows exact computation of the post-change pdfs of some decision statistics even when the support set of the sparse signal is unknown. We apply our detection algorithms with SIC POVM based sequences to a massive random access problem and show their superior performance over conventional Gold codes.

Published
2019

17. CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Author

Charlotte Gehin, Museer A. Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi M. Adeyemi, Erica H. Gerkes, Alexander P.A. Stegmann, Estrella López-Martín, Eva Bermejo-Sánchez, Beatriz Martínez-Delgado, Christiane Zweier, Cornelia Kraus, Bernt Popp, Vincent Strehlow, Daniel Gräfe, Ina Knerr, Eppie R. Jones, Stefano Zamuner, Luciano A. Abriata, Vidya Kunnathully, Brandon E. Moeller, Anthony Vocat, Samuel Rommelaere, Jean-Philippe Bocquete, Evelyne Ruchti, Greta Limoni, Marine Van Campenhoudt, Samuel Bourgeat, Petra Henklein, Christian Gilissen, Bregje W. van Bon, Rolph Pfundt, Marjolein H. Willemsen, Jolanda H. Schieving, Emanuela Leonardi, Fiorenza Soli, Alessandra Murgia, Hui Guo, Qiumeng Zhang, Kun Xia, Christina R. Fagerberg, Christoph P. Beier, Martin J. Larsen, Irene Valenzuela, Paula Fernández-Álvarez, Shiyi Xiong, Robert Śmigiel, Vanesa López-González, Lluís Armengol, Manuela Morleo, Angelo Selicorni, Annalaura Torella, Moira Blyth, Nicola S. Cooper, Valerie Wilson, Renske Oegema, Yvan Herenger, Aurore Garde, Ange-Line Bruel, Frederic Tran Mau-Them, Alexis B.R. Maddocks, Jennifer M. Bain, Musadiq A. Bhat, Gregory Costain, Peter Kannu, Ashish Marwaha, Neena L. Champaigne, Michael J. Friez, Ellen B. Richardson, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Yask Gupta, Tze Y. Lim, Simone Sanna-Cherchi, Bruno Lemaitre, Toshiyuki Yamaji, Kentaro Hanada, John E. Burke, Ana Marjia Jakšić, Brian D. McCabe, Paolo De Los Rios, Thorsten Hornemann, Giovanni D’Angelo, and Vincenzo A. Gennarino

Subjects
Cell biology, Genetics, Medicine
Abstract

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are associated with intellectual disability, but the pathogenic mechanism remains obscure. Here, we characterize 31 individuals with de novo missense variants in CERT1. Several variants fall into a previously uncharacterized dimeric helical domain that enables CERT homeostatic inactivation, without which sphingolipid production goes unchecked. The clinical severity reflects the degree to which CERT autoregulation is disrupted, and inhibiting CERT pharmacologically corrects morphological and motor abnormalities in a Drosophila model of the disease, which we call ceramide transporter (CerTra) syndrome. These findings uncover a central role for CERT autoregulation in the control of sphingolipid biosynthetic flux, provide unexpected insight into the structural organization of CERT, and suggest a possible therapeutic approach for patients with CerTra syndrome.

Published
2023
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18. Teachers' Psychological Well-Being Role of Emotional Intelligence and Resilient Character Traits in Determining the Psychological Well-Being of Indian School Teachers

Author

Kamboj, Kannu Priya and Garg, Pooja

Abstract

Purpose: The substance of the present study lies in analysing the extent to which intrinsic factors like emotional intelligence and resilient character traits impact the psychological well-being of school teachers. It prominences the mediating role of resilient character traits in the relationship between emotional intelligence and psychological well-being of teachers. Design/methodology/approach: This cross-sectional survey study recruits a sample of 200 school teachers across the state of Haryana, India, with the help of a convenience sampling technique. Findings: The findings from parallel multiple mediation indicate perseverance as a significant mediator and predictor of psychological well-being among factors of resilient traits, and self-reliance emerges as an inconsistent, yet significant mediator in the relationship between emotional intelligence and well-being of teachers. The direct effect of emotional intelligence on psychological well-being also emerged as statistically significant. Additionally, the female school teachers show higher emotional intelligence and resilience as compared to the male school teachers. Practical implications: The research is not an unmitigated work in the exploration of a causal relationship between the study variables. However, the study draws practical suggestions for improving the perseverant and emotionally intelligent behaviour of teachers for better emotional and psychological adjustment at work. It acknowledges the role of school administration and education policymakers in furthering the betterment of teachers' psychological state for improved performance and effectiveness. Also, teamwork, stress reduction and leadership building appeared to be helpful contributors to enhance the perseverance and emotional intelligence among teachers. Originality/value: Studies in the field of school administration rarely address the psychological well-being of school teachers as their concern. This study accentuates the impact of intrinsic antecedents of psychological well-being, which is neither well conceptualised in Indian studies nor is causally related to any psychological constructs. Therefore, it remarkably contributes to the literature in the field of educational management and leadership, providing an insight into the psyche of teachers from "the Orient".

Published
2021
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19. Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Author

Koczkowska, Magdalena, Callens, Tom, Gomes, Alicia, Sharp, Angela, Chen, Yunjia, Hicks, Alesha D, Aylsworth, Arthur S, Azizi, Amedeo A, Basel, Donald G, Bellus, Gary, Bird, Lynne M, Blazo, Maria A, Burke, Leah W, Cannon, Ashley, Collins, Felicity, DeFilippo, Colette, Denayer, Ellen, Digilio, Maria C, Dills, Shelley K, Dosa, Laura, Greenwood, Robert S, Griffis, Cristin, Gupta, Punita, Hachen, Rachel K, Hernández-Chico, Concepción, Janssens, Sandra, Jones, Kristi J, Jordan, Justin T, Kannu, Peter, Korf, Bruce R, Lewis, Andrea M, Listernick, Robert H, Lonardo, Fortunato, Mahoney, Maurice J, Ojeda, Mayra Martinez, McDonald, Marie T, McDougall, Carey, Mendelsohn, Nancy, Miller, David T, Mori, Mari, Oostenbrink, Rianne, Perreault, Sebastién, Pierpont, Mary Ella, Piscopo, Carmelo, Pond, Dinel A, Randolph, Linda M, Rauen, Katherine A, Rednam, Surya, Rutledge, S Lane, Saletti, Veronica, Schaefer, G Bradley, Schorry, Elizabeth K, Scott, Daryl A, Shugar, Andrea, Siqveland, Elizabeth, Starr, Lois J, Syed, Ashraf, Trapane, Pamela L, Ullrich, Nicole J, Wakefield, Emily G, Walsh, Laurence E, Wangler, Michael F, Zackai, Elaine, Claes, Kathleen BM, Wimmer, Katharina, van Minkelen, Rick, De Luca, Alessandro, Martin, Yolanda, Legius, Eric, and Messiaen, Ludwine M

Subjects
Biological Sciences, Genetics, Pediatric, Rare Diseases, Neurofibromatosis, Clinical Research, Neurosciences, Brain Disorders, Adolescent, Adult, Child, Child, Preschool, Female, Genetic Association Studies, Genetic Predisposition to Disease, Heterozygote, Humans, Infant, Learning Disabilities, Male, Mutation, Missense, Neurofibroma, Plexiform, Neurofibromatosis 1, Neurofibromin 1, Sequence Deletion, Young Adult, NF1, p.Met992del, genotype-phenotype correlation, neurofibroma, learning difficulties, genotype–phenotype correlation, Clinical Sciences, Genetics & Heredity
Abstract

PurposeNeurofibromatosis type 1 (NF1) is characterized by a highly variable clinical presentation, but almost all NF1-affected adults present with cutaneous and/or subcutaneous neurofibromas. Exceptions are individuals heterozygous for the NF1 in-frame deletion, c.2970_2972del (p.Met992del), associated with a mild phenotype without any externally visible tumors.MethodsA total of 135 individuals from 103 unrelated families, all carrying the constitutional NF1 p.Met992del pathogenic variant and clinically assessed using the same standardized phenotypic checklist form, were included in this study.ResultsNone of the individuals had externally visible plexiform or histopathologically confirmed cutaneous or subcutaneous neurofibromas. We did not identify any complications, such as symptomatic optic pathway gliomas (OPGs) or symptomatic spinal neurofibromas; however, 4.8% of individuals had nonoptic brain tumors, mostly low-grade and asymptomatic, and 38.8% had cognitive impairment/learning disabilities. In an individual with the NF1 constitutional c.2970_2972del and three astrocytomas, we provided proof that all were NF1-associated tumors given loss of heterozygosity at three intragenic NF1 microsatellite markers and c.2970_2972del.ConclusionWe demonstrate that individuals with the NF1 p.Met992del pathogenic variant have a mild NF1 phenotype lacking clinically suspected plexiform, cutaneous, or subcutaneous neurofibromas. However, learning difficulties are clearly part of the phenotypic presentation in these individuals and will require specialized care.

Published
2019

20. Correction: Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype-phenotype correlation.

Author

Koczkowska, Magdalena, Callens, Tom, Gomes, Alicia, Sharp, Angela, Chen, Yunjia, Hicks, Alesha, Aylsworth, Arthur, Azizi, Amedeo, Basel, Donald, Bellus, Gary, Bird, Lynne, Blazo, Maria, Burke, Leah, Cannon, Ashley, Collins, Felicity, DeFilippo, Colette, Denayer, Ellen, Digilio, Maria, Dills, Shelley, Dosa, Laura, Greenwood, Robert, Griffis, Cristin, Gupta, Punita, Hachen, Rachel, Hernández-Chico, Concepción, Janssens, Sandra, Jones, Kristi, Jordan, Justin, Kannu, Peter, Korf, Bruce, Lewis, Andrea, Listernick, Robert, Lonardo, Fortunato, Mahoney, Maurice, Ojeda, Mayra, McDonald, Marie, McDougall, Carey, Mendelsohn, Nancy, Miller, David, Mori, Mari, Oostenbrink, Rianne, Perreault, Sebastién, Pierpont, Mary, Piscopo, Carmelo, Pond, Dinel, Randolph, Linda, Rauen, Katherine, Rednam, Surya, Rutledge, S, Saletti, Veronica, Schaefer, G, Schorry, Elizabeth, Scott, Daryl, Shugar, Andrea, Siqveland, Elizabeth, Starr, Lois, Syed, Ashraf, Trapane, Pamela, Ullrich, Nicole, Wakefield, Emily, Walsh, Laurence, Wangler, Michael, Zackai, Elaine, Claes, Kathleen, Wimmer, Katharina, van Minkelen, Rick, De Luca, Alessandro, Martin, Yolanda, Legius, Eric, and Messiaen, Ludwine

Abstract

A correction has been published to this Article. The PDF and HTML have been updated accordingly.

Published
2019

21. Multi-User Millimeter Wave Channel Estimation Using Generalized Block OMP Algorithm

Author

A, Manoj and Kannu, Arun Pachai

Subjects
Computer Science - Information Theory
Abstract

In a multi-user millimeter (mm) wave communication system, we consider the problem of estimating the channel response between the central node (base station) and each of the user equipments (UE). We propose three different strategies: 1) Each UE estimates its channel separately, 2) Base station estimates all the UEs channels jointly, and 3) Two stage process with estimation done at both UE and base station. Exploiting the low rank nature of the mm wave channels, we propose a generalized block orthogonal matching pursuit (G.BOMP) framework for channel estimation in all the three strategies. Our simulation results show that, the average beamforming gain of the G.BOMP algorithm is higher than that of the conventional OMP algorithm and other existing works on the multi-user mm wave system., Comment: 5 page, 3 figures

Published
2017

22. Distinct Roles of Histone Lysine Demethylases and Methyltransferases in Developmental Eye Disease

Author

Linda M. Reis, Huban Atilla, Peter Kannu, Adele Schneider, Samuel Thompson, Tanya Bardakjian, and Elena V. Semina

Subjects
histone lysine demethylase, histone lysine methyltransferase, KMT2D, KMT2C, SETD1A, KDM6A, Genetics, QH426-470
Abstract

Histone lysine methyltransferase and demethylase enzymes play a central role in chromatin organization and gene expression through the dynamic regulation of histone lysine methylation. Consistent with this, genes encoding for histone lysine methyltransferases (KMTs) and demethylases (KDMs) are involved in complex human syndromes, termed congenital regulopathies. In this report, we present several lines of evidence for the involvement of these genes in developmental ocular phenotypes, suggesting that individuals with structural eye defects, especially when accompanied by craniofacial, neurodevelopmental and growth abnormalities, should be examined for possible variants in these genes. We identified nine heterozygous damaging genetic variants in KMT2D (5) and four other histone lysine methyltransferases/demethylases (KMT2C, SETD1A/KMT2F, KDM6A and KDM5C) in unrelated families affected with developmental eye disease, such as Peters anomaly, sclerocornea, Axenfeld-Rieger spectrum, microphthalmia and coloboma. Two families were clinically diagnosed with Axenfeld-Rieger syndrome and two were diagnosed with Peters plus-like syndrome; others received no specific diagnosis prior to genetic testing. All nine alleles were novel and five of them occurred de novo; five variants resulted in premature truncation, three were missense changes and one was an in-frame deletion/insertion; and seven variants were categorized as pathogenic or likely pathogenic and two were variants of uncertain significance. This study expands the phenotypic spectra associated with KMT and KDM factors and highlights the importance of genetic testing for correct clinical diagnosis.

Published
2023
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25. Prenatal Genetic Testing in the Era of Next Generation Sequencing: A One-Center Canadian Experience

Author

Asra Almubarak, Dan Zhang, Mackenzie Kosak, Sarah Rathwell, Jasmine Doonanco, Alison J. Eaton, Peter Kannu, Joanna Lazier, Monique Lui, Karen Y. Niederhoffer, Melissa J. MacPherson, Melissa Sorsdahl, and Oana Caluseriu

Subjects
prenatal, genetic testing, postnatal, chromosomal microarray, gene panel, whole exome sequencing, Genetics, QH426-470
Abstract

The introduction of next generation sequencing (NGS) technologies has revolutionized the practice of Medical Genetics, and despite initial reticence in its application to prenatal genetics (PG), it is becoming gradually routine, subject to availability. Guidance for the clinical implementation of NGS in PG, in particular whole exome sequencing (ES), has been provided by several professional societies with multiple clinical studies quoting a wide range of testing yields. ES was introduced in our tertiary care center in 2017; however, its use in relation to prenatally assessed cases has been limited to the postnatal period. In this study, we review our approach to prenatal testing including the use of microarray (CMA), and NGS technology (gene panels, ES) over a period of three years. The overall diagnostic yield was 30.4%, with 43.2% of those diagnoses being obtained through CMA, and the majority by using NGS technology (42% through gene panels and 16.6% by ES testing, respectively). Of these, 43.4% of the diagnoses were obtained during ongoing pregnancies. Seventy percent of the abnormal pregnancies tested went undiagnosed. We are providing a contemporary, one tertiary care center retrospective view of a real-life PG practice in the context of an evolving use of NGS within a Canadian public health care system that may apply to many similar jurisdictions around the world.

Published
2022
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27. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author

Naghavi, Mohsen, Ong, Kanyin Liane, Aali, Amirali, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdollahifar, Mohammad-Amin, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abebe, Samrawit Shawel, Abedi, Aidin, Abegaz, Kedir Hussein, Abhilash, E S, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abolmaali, Meysam, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abtahi, Dariush, Abu Rumeileh, Samir, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Accrombessi, Manfred Mario Kokou, Adal, Tadele Girum, Adamu, Abdu A, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adekanmbi, Victor, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adeyinka, Daniel Adedayo, Adeyomoye, Olorunsola Israel, Admass, Biruk Adie Adie, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afolabi, Aanuoluwapo Adeyimika, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agasthi, Pradyumna, Aggarwal, Manik, Aghamiri, Shahin, Agide, Feleke Doyore, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadzade, Amir Mahmoud, Ahmed, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Mehrunnisha Sharif, Ahmed, Meqdad Saleh, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Akara, Essona Matatom, Akbarialiabad, Hossein, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akyirem, Samuel, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Alahdab, Fares, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Alam, Manjurul, Alam, Noore, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Al-Azzam, Sayer, Albakri, Almaza, Albashtawy, Mohammed, AlBataineh, Mohammad T, Alcalde-Rabanal, Jacqueline Elizabeth, Aldawsari, Khalifah A, Aldhaleei, Wafa A, Aldridge, Robert W, Alema, Haileselasie Berhane, Alemayohu, Mulubirhan Assefa, Alemi, Sharifullah, Alemu, Yihun Mulugeta, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhalaiqa, Fadwa Alhalaiqa Naji, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Amjad, Ali, Liaqat, Ali, Mohammed Usman, Ali, Rafat, Ali, Shahid, Ali, Syed Shujait Shujait, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Alikhani, Reyhaneh, Alimohamadi, Yousef, Aliyi, Ahmednur Adem, Aljasir, Mohammad A M, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Al-Marwani, Sabah, Al-Maweri, Sadeq Ali Ali, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Louay, Almidani, Omar, Alomari, Mahmoud A, Al-Omari, Basem, Alonso, Jordi, Alqahtani, Jaber S, Alqalyoobi, Shehabaldin, Alqutaibi, Ahmed Yaseen, Al-Sabah, Salman Khalifah, Altaany, Zaid, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Alwafi, Hassan, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Amani, Reza, Amare, Azmeraw T, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anil, Abhishek, Anil, Sneha, Anoushiravani, Amir, Ansari, Hossein, Ansariadi, Ansariadi, Ansari-Moghaddam, Alireza, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anvari, Saeid, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyasodor, Anayochukwu Edward, Aqeel, Muhammad, Arab, Juan Pablo, Arabloo, Jalal, Arafat, Mosab, Aravkin, Aleksandr Y, Areda, Demelash, Aremu, Abdulfatai, Aremu, Olatunde, Ariffin, Hany, Arkew, Mesay, Armocida, Benedetta, Arndt, Michael Benjamin, Ärnlöv, Johan, Arooj, Mahwish, Artamonov, Anton A, Arulappan, Judie, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Asaad, Malke, Asadi-Lari, Mohsen, Asgedom, Akeza Awealom, Asghariahmadabad, Mona, Asghari-Jafarabadi, Mohammad, Ashraf, Muhammad, Aslani, Armin, Astell-Burt, Thomas, Athar, Mohammad, Athari, Seyyed Shamsadin, Atinafu, Bantalem Tilaye Tilaye, Atlaw, Habtamu Wondmagegn, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Atreya, Alok, Aujayeb, Avinash, Ausloos, Marcel, Avan, Abolfazl, Awedew, Atalel Fentahun, Aweke, Amlaku Mulat, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayuso-Mateos, Jose L, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azevedo, Rui M S, Azzam, Ahmed Y, B, Darshan B, Babu, Abraham Samuel, Badar, Muhammad, Badiye, Ashish D, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bah, Sulaiman, Bahadorikhalili, Saeed, Bahmanziari, Najmeh, Bai, Ruhai, Baig, Atif Amin, Baker, Jennifer L, Bako, Abdulaziz T, Bakshi, Ravleen Kaur, Balakrishnan, Senthilkumar, Balasubramanian, Madhan, Baltatu, Ovidiu Constantin, Bam, Kiran, Banach, Maciej, Bandyopadhyay, Soham, Banik, Palash Chandra, Bansal, Hansi, Bansal, Kannu, Barbic, Franca, Barchitta, Martina, Bardhan, Mainak, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barqawi, Hiba Jawdat, Barrero, Lope H, Barrow, Amadou, Barteit, Sandra, Barua, Lingkan, Basharat, Zarrin, Bashiri, Azadeh, Basiru, Afisu, Baskaran, Pritish, Basnyat, Buddha, Bassat, Quique, Basso, João Diogo, Basting, Ann V L, Basu, Sanjay, Batra, Kavita, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Beaney, Thomas, Bedi, Neeraj, Beghi, Massimiliano, Behboudi, Emad, Behera, Priyamadhaba, Behnoush, Amir Hossein, Behzadifar, Masoud, Beiranvand, Maryam, Bejarano Ramirez, Diana Fernanda, Béjot, Yannick, Belay, Sefealem Assefa, Belete, Chalie Mulu, Bell, Michelle L, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bender, Rose Grace, Bensenor, Isabela M, Beran, Azizullah, Berezvai, Zombor, Berhie, Alemshet Yirga, Berice, Betyna N, Bernstein, Robert S, Bertolacci, Gregory J, Bettencourt, Paulo J G, Beyene, Kebede A, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhalla, Ashish, Bhandari, Dinesh, Bhangdia, Kayleigh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhardwaj, Prarthna V, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhutta, Zulfiqar A, Bikbov, Boris, Bishai, Jessica Devin, Bisignano, Catherine, Bisulli, Francesca, Biswas, Atanu, Biswas, Bijit, Bitaraf, Saeid, Bitew, Bikes Destaw, Bitra, Veera R, Bjørge, Tone, Boachie, Micheal Kofi, Boampong, Mary Sefa, Bobirca, Anca Vasilica, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bogale, Eyob Ketema, Bogale, Kassawmar Angaw, Bohlouli, Somayeh, Bolarinwa, Obasanjo Afolabi, Boloor, Archith, Bonakdar Hashemi, Milad, Bonny, Aime, Bora, Kaustubh, Bora Basara, Berrak, Borhany, Hamed, Borzutzky, Arturo, Bouaoud, Souad, Boustany, Antoine, Boxe, Christopher, Boyko, Edward J, Brady, Oliver J, Braithwaite, Dejana, Brant, Luisa C, Brauer, Michael, Brazinova, Alexandra, Brazo-Sayavera, Javier, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle, Brown, Julie, Brugha, Traolach, Bulamu, Norma B, Bulto, Lemma N, Buonsenso, Danilo, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Chao, Cao, Yin, Capodici, Angelo, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalheiro, Cristina G, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Cederroth, Christopher R, Cegolon, Luca, Cembranel, Francieli, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Cevik, Muge, Chadwick, Joshua, Chahine, Yaacoub, Chakraborty, Chiranjib, Chakraborty, Promit Ananyo, Chan, Jeffrey Shi Kai, Chan, Raymond N C, Chandika, Rama Mohan, Chandrasekar, Eeshwar K, Chang, Chin-Kuo, Chang, Jung-Chen, Chanie, Gashaw Sisay, Charalampous, Periklis, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Chatzimavridou-Grigoriadou, Victoria, Chaurasia, Akhilanand, Chen, Angela W, Chen, An-Tian, Chen, Catherine S, Chen, Haowei, Chen, Meng Xuan, Chen, Simiao, Cheng, Ching-Yu, Cheng, Esther T W, Cherbuin, Nicolas, Cheru, Wondimye Ashenafi, Chien, Ju-Huei, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Choudhari, Sonali Gajanan, Chowdhury, Rajiv, Christopher, Devasahayam J, Chukwu, Isaac Sunday, Chung, Eric, Chung, Erin, Chung, Eunice, Chung, Sheng-Chia, Chutiyami, Muhammad, Cindi, Zinhle, Cioffi, Iolanda, Claassens, Mareli M, Claro, Rafael M, Coberly, Kaleb, Cogen, Rebecca M, Columbus, Alyssa, Comfort, Haley, Conde, Joao, Cortese, Samuele, Cortesi, Paolo Angelo, Costa, Vera Marisa, Costanzo, Simona, Cousin, Ewerton, Couto, Rosa A S, Cowden, Richard G, Cramer, Kenneth Michael, Criqui, Michael H, Cruz-Martins, Natália, Cuadra-Hernández, Silvia Magali, Culbreth, Garland T, Cullen, Patricia, Cunningham, Matthew, Curado, Maria paula, Dadana, Sriharsha, Dadras, Omid, Dai, Siyu, Dai, Xiaochen, Dai, Zhaoli, Dalli, Lachlan L, Damiani, Giovanni, Darega Gela, Jiregna, Das, Jai K, Das, Saswati, Das, Subasish, Dascalu, Ana Maria, Dash, Nihar Ranjan, Dashti, Mohsen, Dastiridou, Anna, Davey, Gail, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davletov, Kairat, De Leo, Diego, de Luca, Katie, Debele, Aklilu Tamire, Debopadhaya, Shayom, Degenhardt, Louisa, Dehghan, Azizallah, Deitesfeld, Lee, Del Bo', Cristian, Delgado-Enciso, Ivan, Demessa, Berecha Hundessa, Demetriades, Andreas K, Deng, Ke, Deng, Xinlei, Denova-Gutiérrez, Edgar, Deravi, Niloofar, Dereje, Nebiyu, Dervenis, Nikolaos, Dervišević, Emina, Des Jarlais, Don C, Desai, Hardik Dineshbhai, Desai, Rupak, Devanbu, Vinoth Gnana Chellaiyan, Dewan, Syed Masudur Rahman, Dhali, Arkadeep, Dhama, Kuldeep, Dhimal, Meghnath, Dhingra, Sameer, Dhulipala, Vishal R, Dias da Silva, Diana, Diaz, Daniel, Diaz, Michael J, Dima, Adriana, Ding, Delaney D, Ding, Huanghe, Dinis-Oliveira, Ricardo Jorge, Dirac, M Ashworth, Djalalinia, Shirin, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Doaei, Saeid, Dodangeh, Masoud, Dodangeh, Milad, Dohare, Sushil, Dokova, Klara Georgieva, Dolecek, Christiane, Dominguez, Regina-Mae Villanueva, Dong, Wanyue, Dongarwar, Deepa, D'Oria, Mario, Dorostkar, Fariba, Dorsey, E Ray, dos Santos, Wendel Mombaque, Doshi, Rajkumar, Doshmangir, Leila, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Haneil Larson, Dsouza, Viola, Du, Mi, Dube, John, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dwyer-Lindgren, Laura, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, E'mar, Abdel Rahman, Eboreime, Ejemai, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Defi, Efendi, Ferry, Effendi, Diyan Ermawan, Eikemo, Terje Andreas, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Sayed, Iman, Elbarazi, Iffat, Elema, Teshome Bekele, Elemam, Noha Mousaad, Elgar, Frank J, Elgendy, Islam Y, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, El-Huneidi, Waseem, Elilo, Legesse Tesfaye, Elmeligy, Omar Abdelsadek Abdou, Elmonem, Mohamed A, Elshaer, Mohammed, Elsohaby, Ibrahim, Emeto, Theophilus I, Engelbert Bain, Luchuo, Erkhembayar, Ryenchindorj, Esezobor, Christopher Imokhuede, Eshrati, Babak, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Esubalew, Habtamu, Etaee, Farshid, Fabin, Natalia, Fadaka, Adewale Oluwaseun, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Fahimi, Saman, Fakhri-Demeshghieh, Aliasghar, Falzone, Luca, Fareed, Mohammad, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Faris, Pawan Sirwan, Faro, Andre, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fattahi, Hamed, Fauk, Nelsensius Klau, Fazeli, Pooria, Feigin, Valery L, Feizkhah, Alireza, Fekadu, Ginenus, Feng, Xiaoru, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrante, Daniela, Ferrari, Alize J, Ferreira, Nuno, Fetensa, Getahun, Feyisa, Bikila Regassa, Filip, Irina, Fischer, Florian, Flavel, Joanne, Flood, David, Florin, Bobirca Teodor, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Behzad, Foroutan, Masoud, Forthun, Ingeborg, Fortuna, Daniela, Foschi, Matteo, Fowobaje, Kayode Raphael, Francis, Kate Louise, Franklin, Richard Charles, Freitas, Alberto, Friedman, Joseph, Friedman, Sara D, Fukumoto, Takeshi, Fuller, John E, Fux, Blima, Gaal, Peter Andras, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Gakidou, Emmanuela, Galali, Yaseen, Galles, Natalie C, Gallus, Silvano, Ganbat, Mandukhai, Gandhi, Aravind P, Ganesan, Balasankar, Ganiyani, Mohammad Arfat, Garcia-Gordillo, MA, Gardner, William M, Garg, Jalaj, Garg, Naval, Gautam, Rupesh K, Gbadamosi, Semiu Olatunde, Gebi, Tilaye Gebru, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremeskel, Teferi Gebru, Georgescu, Simona Roxana, Getachew, Tamirat, Gething, Peter W, Getie, Molla, Ghadiri, Keyghobad, Ghahramani, Sulmaz, Ghailan, Khalid Yaser, Ghasemi, Mohammad-Reza, Ghasempour Dabaghi, Ghazal, Ghasemzadeh, Afsaneh, Ghashghaee, Ahmad, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Ghimire, Ajnish, Ghoba, Sama, Gholamalizadeh, Maryam, Gholamian, Asadollah, Gholamrezanezhad, Ali, Gholizadeh, Nasim, 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Sabour, Siamak, Sacco, Simona, Sachdev, Perminder S, Sachdeva, Rajesh, Saddik, Basema, Saddler, Adam, Sadee, Bashdar Abuzed, Sadeghi, Ehsan, Sadeghi, Erfan, Sadeghian, Farideh, Saeb, Mohammad Reza, Saeed, Umar, Safaeinejad, Fahimeh, Safi, Sher Zaman, Sagar, Rajesh, Saghazadeh, Amene, Sagoe, Dominic, Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahoo, Umakanta, Sahu, Monalisha, Saif, Zahra, Sajid, Mirza Rizwan, Sakshaug, Joseph W, Salam, Nasir, Salamati, Payman, Salami, Afeez Abolarinwa, Salaroli, Luciane B, Saleh, Mohamed A, Salehi, Sana, Salem, Marwa Rashad, Salem, Mohammed Z Y, Salimi, Sohrab, Samadi Kafil, Hossein, Samadzadeh, Sara, Samargandy, Saad, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Sanna, Francesca, Santomauro, Damian Francesco, Santos, Itamar S, Santric-Milicevic, Milena M, Sao Jose, Bruno Piassi, Sarasmita, Made Ary, Saraswathy, Sivan Yegnanarayana Iyer, Saravanan, Aswini, Saravi, Babak, Sarikhani, Yaser, Sarkar, Tanmay, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Satpathy, Maheswar, Sayeed, Abu, Sayeed, Md Abu, Saylan, Mete, Sayyah, Mehdi, Scarmeas, Nikolaos, Schaarschmidt, Benedikt Michael, Schlaich, Markus P, Schlee, Winfried, Schmidt, Maria Inês, Schneider, Ione Jayce Ceola, Schuermans, Art, Schumacher, Austin E, Schutte, Aletta Elisabeth, Schwarzinger, Michaël, Schwebel, David C, Schwendicke, Falk, Šekerija, Mario, Selvaraj, Siddharthan, Senapati, Sabyasachi, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, Sethi, Yashendra, Sha, Feng, Shabany, Maryam, Shafaat, Amir, Shafie, Mahan, Shah, Nilay S, Shah, Pritik A, Shah, Syed Mahboob, Shahabi, Saeed, Shahbandi, Ataollah, Shahid, Izza, Shahid, Samiah, Shahid, Wajeehah, Shahsavari, Hamid R, Shahwan, Moyad Jamal, Shaikh, Ahmed, Shaikh, Masood Ali, Shakeri, Alireza, Shalash, Ali S, Sham, Sunder, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamshad, Hina, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Sharfaei, Sadaf, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Rajesh, Sharma, Saurab, Sharma, Ujjawal, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shayan, Maryam, Shehabeldine, Amr Mohamed Elsayed, Sheikh, Aziz, Sheikhi, Rahim Ali, Shen, Jiabin, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shi, Peilin, Shibuya, Kenji, Shiferaw, Desalegn, Shigematsu, Mika, Shin, Min-Jeong, Shin, Youn Ho, Shiri, Rahman, Shirkoohi, Reza, Shitaye, Nebiyu Aniley, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shivarov, Velizar, Shokraneh, Farhad, Shokri, Azad, Shool, Sina, Shorofi, Seyed Afshin, Shrestha, Sunil, Shuval, Kerem, Siddig, Emmanuel Edwar, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Garima, Singh, Jasbir, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Sinha, Dhirendra Narain, Sinto, Robert, Siraj, Md Shahjahan, Sirota, Sarah Brooke, Sitas, Freddy, Sivakumar, Shravan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Socea, Bogdan, Sokhan, Anton, Solanki, Ranjan, Solanki, Shipra, Soleimani, Hamidreza, Soliman, Sameh S M, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Sreeramareddy, Chandrashekhar T, Srivastava, Vijay Kumar, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Stark, Benjamin A, Starnes, Joseph R, Starodubova, Antonina V, Stein, Caroline, Stein, Dan J, Steinbeis, Fridolin, Steiner, Caitlyn, Steinmetz, Jaimie D, Steiropoulos, Paschalis, Stevanović, Aleksandar, Stockfelt, Leo, Stokes, Mark A, Stortecky, Stefan, Subramaniyan, Vetriselvan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Haitong Zhe, Sun, Jing, Sundström, Johan, Sunkersing, David, Sunnerhagen, Katharina S, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabish, Mohammad, TADAKAMADLA, JYOTHI, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taiba, Jabeen, Takahashi, Ken, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tandukar, Sarmila, Tang, Haosu, Tang, Hong K, Tarigan, Ingan Ukur, Tariku, Mengistie Kassahun, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesler, Riki, Teye-Kwadjo, Enoch, Thakur, Rishu, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Tharwat, Samar, Thayakaran, Rasiah, Thomas, Nihal, Thomas, Nikhil Kenny, Thomson, Azalea M, Thrift, Amanda G, Thum, Chern Choong Chern, Thygesen, Lau Caspar, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Titova, Mariya Vladimirovna, Tonelli, Marcello, Topor-Madry, Roman, Toriola, Adetunji T, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Jasmine T, Tran, Nghia Minh, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Uddin, Sayed Mohammad Nazim, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Irfan, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Unsworth, Carolyn Anne, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, Van de Velde, Sarah M, Van den Eynde, Jef, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Viskadourou, Maria, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Ning, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Waqas, Muhammad, Ward, Paul, Wassie, Emebet Gashaw, Watson, Stefanie, Watson, Stephanie Louise Watson, Weerakoon, Kosala Gayan, Wei, Melissa Y, Weintraub, Robert G, Weiss, Daniel J, Westerman, Ronny, Whisnant, Joanna L, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wilandika, Angga, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wojewodzic, Marcin W, Woldegebreal, Demewoz H, Wolf, Axel Walter, Wolfe, Charles D A, Wondimagegene, Yohannes Addisu, Wong, Yen Jun, Wongsin, Utoomporn, Wu, Ai-Min, Wu, Chenkai, Wu, Felicia, Wu, Xinsheng, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xie, Yang, Xu, Suowen, Xu, Wang-Dong, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadollahpour, Ali, Yamagishi, Kazumasa, Yang, Danting, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesiltepe, Metin, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yigezu, Amanuel, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yismaw, Malede Berihun, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yoon, Seok-Jun, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Yuh, Faith H, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zakham, Fathiah, Zaki, Nazar, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zangiabadian, Moein, Zar, Heather J, Zare, Iman, Zarrintan, Armin, Zeariya, Mohammed G M, Zeinali, Zahra, Zhang, Haijun, Zhang, Jianrong, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Lei, Ziafati, Makan, Zielińska, Magdalena, Zitoun, Osama A, Zoladl, Mohammad, Zou, Zhiyong, Zuhlke, Liesl J, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Wool, Eve E, and Murray, Christopher J L

Abstract

Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations.

Published
2024
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28. Direct Reprogramming of Fibroblasts to Osteoblasts: Techniques and Methodologies

Author

Fallah, Asghar, Beke, Alexander, Oborn, Connor, Soltys, Carrie-Lynn, and Kannu, Peter

Abstract

Direct reprogramming (DR) is an emerging technique that can be applied to convert fibroblasts into osteoblast-like cells, promoting bone formation and regeneration. We review the current methodology of DR in relation to the creation of induced osteoblasts, including a comparison of transcription factor-mediated reprogramming and nontranscription factor-mediated reprogramming. We review the selection of reprogramming factors and delivery systems required. Transcription factor cocktails, such as the RXOL cocktail (Runx2, Osx, OCT3/4, and L-MYC), have shown promise in inducing osteogenic differentiation in fibroblasts. Alterations to the original cocktail, such as the addition of Oct9 and N-myc, have resulted in improved reprogramming efficiency. Transcription factor delivery includes integrative and nonintegrative systems which encompass viral vectors and nonviral methods such as synthetic RNA. Recently, an integrative approach using self-replicating RNA has been developed to achieve a longer and more sustained transcription factor expression. Nontranscription factor-mediated reprogramming using small molecules, proteins, inhibitors, and agonists has also been explored. For example, IGFBP7 protein supplementation and ALK5i-II inhibitor treatment have shown potential in enhancing osteoblast reprogramming. Direct reprogramming methods hold great promise for advancing bone regeneration and tissue repair, providing a potential therapeutic approach for fracture healing and the repair of bone defects. Multiple obstacles and constraints need to be addressed before a clinically significant level of cell therapy will be reached. Further research is needed to optimize the efficiency of the reprogramming cocktails, delivery methods, and safety profile of the reprogramming process.Graphical Abstract

Published
2024
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29. On Communication over Unknown Sparse Frequency-Selective Block-Fading Channels

Author

Kannu, Arun Pachai and Schniter, Philip

Subjects
Computer Science - Information Theory
Abstract

This paper considers the problem of reliable communication over discrete-time channels whose impulse responses have length $L$ and exactly $S\leq L$ non-zero coefficients, and whose support and coefficients remain fixed over blocks of $N>L$ channel uses but change independently from block to block. Here, it is assumed that the channel's support and coefficient realizations are both unknown, although their statistics are known. Assuming Gaussian non-zero-coefficients and noise, and focusing on the high-SNR regime, it is first shown that the ergodic noncoherent channel capacity has pre-log factor $1-\frac{S}{N}$ for any $L$. It is then shown that, to communicate with arbitrarily small error probability at rates in accordance with the capacity pre-log factor, it suffices to use pilot-aided orthogonal frequency-division multiplexing (OFDM) with $S$ pilots per fading block, in conjunction with an appropriate noncoherent decoder. Since the achievability result is proven using a noncoherent decoder whose complexity grows exponentially in the number of fading blocks $K$, a simpler decoder, based on $S+1$ pilots, is also proposed. Its $\epsilon$-achievable rate is shown to have pre-log factor equal to $1-\frac{S+1}{N}$ with the previously considered channel, while its achievable rate is shown to have pre-log factor $1-\frac{S+1}{N}$ when the support of the block-fading channel remains fixed over time., Comment: To appear in IEEE Transactions on Information Theory

Published
2010

30. Atypical COL3A1 variants (glutamic acid to lysine) cause vascular Ehlers–Danlos syndrome with a consistent phenotype of tissue fragility and skin hyperextensibility

Author

Ghali, Neeti, Baker, Duncan, Brady, Angela F., Burrows, Nigel, Cervi, Elena, Cilliers, Deirdre, Frank, Michael, Germain, Dominique P., Hulmes, David J. S., Jacquemont, Marie-line, Kannu, Peter, Lefroy, Henrietta, Legrand, Anne, Pope, F. Michael, Robertson, Lisa, Vandersteen, Anthony, von Klemperer, Kate, Warburton, Renarta, Whiteford, Margo, and van Dijk, Fleur S.

Published
2019
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33. Generalized Sparse Regression Codes for Short Block Lengths

Author

Sinha, Madhusudan Kumar and Kannu, Arun Pachai

Abstract

Sparse Regression Code (SPARC) connects the sparse signal recovery framework with the error control coding techniques. In this paper, we focus on improving the block error performance of SPARC in short block length regime over the AWGN channel. Towards that, we introduce suitable candidates for dictionary matrices in real and complex fields using Gold sequences and mutually unbiased bases (MUB). We propose two generalizations of SPARC (GSPARC), develop a greedy decoder called Match and Decode (MAD) algorithm, and provide its analytical noiseless recovery guarantees. We propose a parallel greedy search technique called parallel MAD (PMAD) to improve performance. We describe the applicability of GSPARC with PMAD decoder for multi-user channels, providing a non-orthogonal multiple access scheme. We present numerical results comparing the block error rate (BLER) performance of the proposed algorithms for GSPARC in AWGN channels in the short block length regime. The PMAD decoder gives better BLER than the approximate message-passing decoder for SPARC. GSPARC with PMAD gives comparable and competitive BLER performance compared to other existing codes. In multi-user channels, GSPARC with PMAD decoder outperforms the sphere packing lower bounds of an orthogonal multiple access scheme with the same spectral efficiency.

Published
2024
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34. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes

Author

Kent, Oliver A., Saha, Manipa, Coyaud, Etienne, Burston, Helen E., Law, Napoleon, Dadson, Keith, Chen, Sujun, Laurent, Estelle M., St-Germain, Jonathan, Sun, Ren X., Matsumoto, Yoshinori, Cowen, Justin, Montgomery-Song, Aaryn, Brown, Kevin R., Ishak, Charles, Rose, Jose La, De Carvalho, Daniel D., He, Housheng Hansen, Raught, Brian, Billia, Filio, Kannu, Peter, and Rottapel, Robert

Published
2020
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35. Association Between Polyvascular Disease and Transcatheter Aortic Valve Replacement Outcomes: Insights From the STS/ACC TVT Registry.

Author

Bansal, Kannu, Soni, Aakriti, Shah, Miloni, Kosinski, Andrzej S., Gilani, Fahad, Khera, Sahil, Vemulapalli, Sreekanth, Elmariah, Sammy, and Kolte, Dhaval

Abstract

BACKGROUND: Atherosclerotic cardiovascular disease is highly prevalent in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Polyvascular disease (PVD), defined as involvement of ≥2 vascular beds (VBs), that is, coronary, cerebrovascular, or peripheral, portends a poor prognosis in patients with atherosclerotic cardiovascular disease; however, data on the association of PVD with outcomes of patients undergoing TAVR are limited. METHODS: The Society of Thoracic Surgeons and the American College of Cardiology Transcatheter Valve Therapy Registry was analyzed to identify patients who underwent TAVR from November 2011 to March 2022. The exposure of interest was PVD. The primary outcome was all-cause mortality. Secondary outcomes included major vascular complications, major/lifethreatening bleeding, myocardial infarction, transient ischemic attack/stroke, and valve- and non--valve-related readmissions. Outcomes were assessed at 30 days and 1 year. RESULTS: Of 443 790 patients who underwent TAVR, PVD was present in 150 823 (34.0%; 111 425 [25.1%] with 2VBPVD and 39 398 [8.9%] with 3VB-PVD). On multivariable analysis, PVD was associated with increased all-cause mortality at 1 year (hazard ratio, 1.17 [95% CI, 1.14-1.20]). There was an incremental increase in 1-year mortality with an increasing number of VBs involved (no PVD [reference]; 2VB-PVD: hazard ratio, 1.12 [95% CI, 1.09-1.15]: and 3VB-PVD: hazard ratio, 1.31 [95% CI, 1.26-1.36]). Patients with versus without PVD had higher rates of major vascular complications, major/lifethreatening bleeding, transient ischemic attack/stroke, and non--valve-related readmissions at 30 days and 1 year. CONCLUSIONS: PVD is associated with worse outcomes after TAVR, and the risk is highest in patients with 3VB-PVD. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Parallel Greedy Search for Random Access in Wireless Networks

Author

Kumar, Rahul, Sinha, Madhusudan Kumar, and Kannu, Arun Pachai

Abstract

We consider the random access problem in wireless networks such as cellular networks and massive machine type communication networks, where a large number of devices/users are connected to a base station. In order to establish communication with the base station, as a part of the random access procedure, active users select and transmit codes (pilot sequences) randomly from a codebook. Since the active users are typically a small fraction of the total users, sparse signal recovery algorithms are employed to detect the transmitted codes. In this paper, we use multiple measurement vector model for the received signal and develop a parallel greedy search algorithm and it’s stopping criteria to detect the active users. We show through simulations that the proposed scheme, compared with the existing greedy algorithms, gives better detection performance at lower false alarms levels. We study how the code length and the code word size need to be chosen in order to detect a given number of active users. We also address the scenario when there are different timing offsets for signals received from different users.

Published
2023
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42. Spondyloepimetaphyseal dysplasia with joint laxity type 2: Aggregating the literature and reporting on the life of a 66‐year‐old man

Author

Beke, Alexander, Costa Silveira, Karina, Athey, Taryn, and Kannu, Peter

Abstract

Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type (SEMDJL2), is a rare bone dysplasia that results from hotspot (amino acids148/149) mutations in KIF22. Clinically, affected individuals present with generalized joint laxity, limb malalignment, midface hypoplasia, gracile digits, postnatal short stature, and occasionally, tracheolaryngomalacia; additionally, radiological features include severe epi‐metaphyseal abnormalities and slender metacarpals. This report evaluates the progression of SEMDJL2 throughout the life of the oldest individual reported in the literature—a 66‐year‐old man with a pathogenic KIF22variant (c.443C > T, p.Pro148Leu). The proband developed many of the clinical and radiological alterations consistent with the presentation of other individuals in the literature. Interestingly, throughout his life, joint limitation progressed, beginning with knee and elbow stricture (year 20), and later, limitation of the shoulders, hips, ankles, and wrists (year 40). This differs from previous case reports, where joint limitation is identified in 1‐to‐2 joints. Cumulatively, the progressive body‐wide joint limitation resulted in early retirement (year 45) and difficulty completing daily tasks and managing personal hygiene culminating in the need for assisted living (year 65). In conclusion, we report on the clinical and radiological developments of a 66‐year‐old man with SEMDJL2, that developed significant joint limitation in adulthood.

Published
2023
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45. Analysis of Beam Sweeping Techniques for Cell-Discovery in Millimeter Wave Systems

Author

Rashmi, P., Manoj, A., and Pachai Kannu, Arun

Abstract

Cell discovery is the procedure in which a user equipment (UE) finds a suitable base station (BS) to establish a communication link. When beamforming with antenna arrays is done at both transmitter and receiver, cell discovery in mm wave systems also involves finding the correct angle of arrival – angle of departure alignment between the UE and the detected BS. First, we consider the single BS scenario and present the mathematical model for the cell discovery problem. We present the details of the beam sweeping based techniques and explain the beam combining scheme to reduce the training overhead. We analytically characterize the performance of energy detector at the UE for both beam sweeping and beam combining methods under some channel assumptions. Further, we consider the multiple BS case where BSs transmit synchronization signals along with directional beamforming. We analyze the performance of the energy detector in this case as well. We finally present simulation studies with channels generated using generic mm wave channel emulators and draw inferences on the role of various parameters on the cell discovery performance.

Published
2023
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49. Lightning-induced voltages in a satellite launch-pad protection system

Author

Kannu, P. Durai and Thomas, M. Joy

Subjects
Lightning protection -- Research, Business, Computers, Electronics, Electronics and electrical industries
Abstract

Modern satellite launch pads are provided with lightning protection systems to take care of direct lightning strike to the satellite launch vehicle during the launch preparation period. This paper presents the results of the study on induced voltage on the conductors interlinking the towers of such a protection system due to a nearby lightning strike. The variation in the induced voltages with lightning-strike distances as well as ground conductivities are studied and the results presented in the paper. It has been seen that the waveshape of the induced voltage depends on conductor height and striking distance, whereas the ground conductivity has negligible effect on the induced voltage. Index Terms--Electromagnetic field coupling, ground conductivity, induced voltages, lightning protection, satellite launch pad.

Published
2003

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