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1. Figure S2. from High-Specificity CRISPR-Mediated Genome Engineering in Anti-BCMA Allogeneic CAR T Cells Suppresses Allograft Rejection in Preclinical Models

Author

Degagné, Émilie, primary, Donohoue, Paul D., primary, Roy, Suparna, primary, Scherer, Jessica, primary, Fowler, Tristan W., primary, Davis, Ryan T., primary, Reyes, Gustavo A., primary, Kwong, George, primary, Stanaway, Morena, primary, Larroca Vicena, Vanina, primary, Mutha, Devin, primary, Guo, Raymond, primary, Edwards, Leslie, primary, Schilling, Benjamin, primary, Shaw, McKay, primary, Smith, Stephen C., primary, Kohrs, Bryan, primary, Kufeldt, Heinrich J., primary, Churchward, Glen, primary, Ruan, Finey, primary, Nyer, David B., primary, McSweeney, Kyle, primary, Irby, Matthew J., primary, Fuller, Christopher K., primary, Banh, Lynda, primary, Toh, Mckenzi S., primary, Thompson, Matthew, primary, Owen, Arthur L.G., primary, An, Zili, primary, Gradia, Scott, primary, Skoble, Justin, primary, Bryan, Mara, primary, Garner, Elizabeth, primary, and Kanner, Steven B., primary

Published
2024
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2. Supplementary Tables from High-Specificity CRISPR-Mediated Genome Engineering in Anti-BCMA Allogeneic CAR T Cells Suppresses Allograft Rejection in Preclinical Models

Author

Degagné, Émilie, primary, Donohoue, Paul D., primary, Roy, Suparna, primary, Scherer, Jessica, primary, Fowler, Tristan W., primary, Davis, Ryan T., primary, Reyes, Gustavo A., primary, Kwong, George, primary, Stanaway, Morena, primary, Larroca Vicena, Vanina, primary, Mutha, Devin, primary, Guo, Raymond, primary, Edwards, Leslie, primary, Schilling, Benjamin, primary, Shaw, McKay, primary, Smith, Stephen C., primary, Kohrs, Bryan, primary, Kufeldt, Heinrich J., primary, Churchward, Glen, primary, Ruan, Finey, primary, Nyer, David B., primary, McSweeney, Kyle, primary, Irby, Matthew J., primary, Fuller, Christopher K., primary, Banh, Lynda, primary, Toh, Mckenzi S., primary, Thompson, Matthew, primary, Owen, Arthur L.G., primary, An, Zili, primary, Gradia, Scott, primary, Skoble, Justin, primary, Bryan, Mara, primary, Garner, Elizabeth, primary, and Kanner, Steven B., primary

Published
2024
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3. Data from High-Specificity CRISPR-Mediated Genome Engineering in Anti-BCMA Allogeneic CAR T Cells Suppresses Allograft Rejection in Preclinical Models

Author

Degagné, Émilie, primary, Donohoue, Paul D., primary, Roy, Suparna, primary, Scherer, Jessica, primary, Fowler, Tristan W., primary, Davis, Ryan T., primary, Reyes, Gustavo A., primary, Kwong, George, primary, Stanaway, Morena, primary, Larroca Vicena, Vanina, primary, Mutha, Devin, primary, Guo, Raymond, primary, Edwards, Leslie, primary, Schilling, Benjamin, primary, Shaw, McKay, primary, Smith, Stephen C., primary, Kohrs, Bryan, primary, Kufeldt, Heinrich J., primary, Churchward, Glen, primary, Ruan, Finey, primary, Nyer, David B., primary, McSweeney, Kyle, primary, Irby, Matthew J., primary, Fuller, Christopher K., primary, Banh, Lynda, primary, Toh, Mckenzi S., primary, Thompson, Matthew, primary, Owen, Arthur L.G., primary, An, Zili, primary, Gradia, Scott, primary, Skoble, Justin, primary, Bryan, Mara, primary, Garner, Elizabeth, primary, and Kanner, Steven B., primary

Published
2024
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4. Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas

Author

Burger, Brian T., primary, Beaton, Benjamin P., additional, Campbell, Matthew A., additional, Brett, Benjamin T., additional, Rohrer, Melissa S., additional, Plummer, Sarah, additional, Barnes, Dylan, additional, Jiang, Ke, additional, Naswa, Sudhir, additional, Lange, Jeremy, additional, Ott, Alina, additional, Alger, Elizabeth, additional, Rincon, Gonzalo, additional, Rounsley, Steven, additional, Betthauser, Jeff, additional, Mtango, Namdori R., additional, Benne, Joshua A., additional, Hammerand, Jessica, additional, Durfee, Codie J., additional, Rotolo, Marisa L., additional, Cameron, Peter, additional, Lied, Alexandra M., additional, Irby, Matthew J., additional, Nyer, David B., additional, Fuller, Chris K., additional, Gradia, Scott, additional, Kanner, Steven B., additional, Park, Ki-Eun, additional, Waters, Jerel, additional, Simpson, Sean, additional, Telugu, Bhanu P., additional, Salgado, Brianna C., additional, Brandariz-Nuñez, Alberto, additional, Rowland, Raymond R.R., additional, Culbertson, Matt, additional, Rice, Elena, additional, and Cigan, A. Mark, additional

Published
2024
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5. Harnessing type I CRISPR–Cas systems for genome engineering in human cells

Author

Cameron, Peter, Coons, Mary M., Klompe, Sanne E., Lied, Alexandra M., Smith, Stephen C., Vidal, Bastien, Donohoue, Paul D., Rotstein, Tomer, Kohrs, Bryan W., Nyer, David B., Kennedy, Rachel, Banh, Lynda M., Williams, Carolyn, Toh, Mckenzi S., Irby, Matthew J., Edwards, Leslie S., Lin, Chun-Han, Owen, Arthur L. G., Künne, Tim, van der Oost, John, Brouns, Stan J. J., Slorach, Euan M., Fuller, Chris K., Gradia, Scott, Kanner, Steven B., May, Andrew P., and Sternberg, Samuel H.

Published
2019
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7. Supplementary methods from HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Author

Wong, So C., primary, Cheng, Weijun, primary, Hamilton, Holly, primary, Nicholas, Anthony L., primary, Wakefield, Darren H., primary, Almeida, Aaron, primary, Blokhin, Andrei V., primary, Carlson, Jeffrey, primary, Neal, Zane C., primary, Subbotin, Vladimir, primary, Zhang, Guofeng, primary, Hegge, Julia, primary, Bertin, Stephanie, primary, Trubetskoy, Vladimir S., primary, Rozema, David B., primary, Lewis, David L., primary, and Kanner, Steven B., primary

Published
2023
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8. Figure S5 from HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Author

Wong, So C., primary, Cheng, Weijun, primary, Hamilton, Holly, primary, Nicholas, Anthony L., primary, Wakefield, Darren H., primary, Almeida, Aaron, primary, Blokhin, Andrei V., primary, Carlson, Jeffrey, primary, Neal, Zane C., primary, Subbotin, Vladimir, primary, Zhang, Guofeng, primary, Hegge, Julia, primary, Bertin, Stephanie, primary, Trubetskoy, Vladimir S., primary, Rozema, David B., primary, Lewis, David L., primary, and Kanner, Steven B., primary

Published
2023
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9. Data from HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Author

Wong, So C., primary, Cheng, Weijun, primary, Hamilton, Holly, primary, Nicholas, Anthony L., primary, Wakefield, Darren H., primary, Almeida, Aaron, primary, Blokhin, Andrei V., primary, Carlson, Jeffrey, primary, Neal, Zane C., primary, Subbotin, Vladimir, primary, Zhang, Guofeng, primary, Hegge, Julia, primary, Bertin, Stephanie, primary, Trubetskoy, Vladimir S., primary, Rozema, David B., primary, Lewis, David L., primary, and Kanner, Steven B., primary

Published
2023
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10. Table S1 and S2 from HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Author

Wong, So C., primary, Cheng, Weijun, primary, Hamilton, Holly, primary, Nicholas, Anthony L., primary, Wakefield, Darren H., primary, Almeida, Aaron, primary, Blokhin, Andrei V., primary, Carlson, Jeffrey, primary, Neal, Zane C., primary, Subbotin, Vladimir, primary, Zhang, Guofeng, primary, Hegge, Julia, primary, Bertin, Stephanie, primary, Trubetskoy, Vladimir S., primary, Rozema, David B., primary, Lewis, David L., primary, and Kanner, Steven B., primary

Published
2023
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11. Supplementary Figure Legends from Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

Author

Parnell, K. Mark, primary, Foulks, Jason M., primary, Nix, Rebecca N., primary, Clifford, Adrianne, primary, Bullough, Jeremy, primary, Luo, Bai, primary, Senina, Anna, primary, Vollmer, David, primary, Liu, Jihua, primary, McCarthy, Virgil, primary, Xu, Yong, primary, Saunders, Michael, primary, Liu, Xiao-Hui, primary, Pearce, Scott, primary, Wright, Kevin, primary, O'Reilly, Marc, primary, McCullar, Michael V., primary, Ho, Koc-Kan, primary, and Kanner, Steven B., primary

Published
2023
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12. Supplementary Figures 1-4 from Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

Author

Parnell, K. Mark, primary, Foulks, Jason M., primary, Nix, Rebecca N., primary, Clifford, Adrianne, primary, Bullough, Jeremy, primary, Luo, Bai, primary, Senina, Anna, primary, Vollmer, David, primary, Liu, Jihua, primary, McCarthy, Virgil, primary, Xu, Yong, primary, Saunders, Michael, primary, Liu, Xiao-Hui, primary, Pearce, Scott, primary, Wright, Kevin, primary, O'Reilly, Marc, primary, McCullar, Michael V., primary, Ho, Koc-Kan, primary, and Kanner, Steven B., primary

Published
2023
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13. Data from Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

Author

Parnell, K. Mark, primary, Foulks, Jason M., primary, Nix, Rebecca N., primary, Clifford, Adrianne, primary, Bullough, Jeremy, primary, Luo, Bai, primary, Senina, Anna, primary, Vollmer, David, primary, Liu, Jihua, primary, McCarthy, Virgil, primary, Xu, Yong, primary, Saunders, Michael, primary, Liu, Xiao-Hui, primary, Pearce, Scott, primary, Wright, Kevin, primary, O'Reilly, Marc, primary, McCullar, Michael V., primary, Ho, Koc-Kan, primary, and Kanner, Steven B., primary

Published
2023
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14. Figure S4 from HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans

Author

Ma, Yuanqing, primary, Joyce, Allison, primary, Brandenburg, Olivia, primary, Saatchi, Faeze, primary, Stevens, Christina, primary, Toffessi Tcheuyap, Vanina, primary, Christie, Alana, primary, Do, Quyen N., primary, Fatunde, Oluwatomilade, primary, Macchiaroli, Alyssa, primary, Wong, So C., primary, Woolford, Layton, primary, Yousuf, Qurratulain, primary, Miyata, Jeffrey, primary, Carrillo, Deyssy, primary, Onabolu, Oreoluwa, primary, McKenzie, Tiffani, primary, Mishra, Akhilesh, primary, Hardy, Tanner, primary, He, Wei, primary, Li, Daniel, primary, Ivanishev, Alexander, primary, Zhang, Qing, primary, Pedrosa, Ivan, primary, Kapur, Payal, primary, Schluep, Thomas, primary, Kanner, Steven B., primary, Hamilton, James, primary, and Brugarolas, James, primary

Published
2023
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15. Table S2 from HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans

Author

Ma, Yuanqing, primary, Joyce, Allison, primary, Brandenburg, Olivia, primary, Saatchi, Faeze, primary, Stevens, Christina, primary, Toffessi Tcheuyap, Vanina, primary, Christie, Alana, primary, Do, Quyen N., primary, Fatunde, Oluwatomilade, primary, Macchiaroli, Alyssa, primary, Wong, So C., primary, Woolford, Layton, primary, Yousuf, Qurratulain, primary, Miyata, Jeffrey, primary, Carrillo, Deyssy, primary, Onabolu, Oreoluwa, primary, McKenzie, Tiffani, primary, Mishra, Akhilesh, primary, Hardy, Tanner, primary, He, Wei, primary, Li, Daniel, primary, Ivanishev, Alexander, primary, Zhang, Qing, primary, Pedrosa, Ivan, primary, Kapur, Payal, primary, Schluep, Thomas, primary, Kanner, Steven B., primary, Hamilton, James, primary, and Brugarolas, James, primary

Published
2023
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16. Allogeneic chimeric antigen receptor-T cells with CRISPR-disrupted programmed death-1 checkpoint exhibit enhanced functional fitness

Author

Lau, Elaine, primary, Kwong, George, additional, Fowler, Tristan W., additional, Sun, Bee-Chun, additional, Donohoue, Paul D., additional, Davis, Ryan T., additional, Bryan, Mara, additional, McCawley, Shannon, additional, Clarke, Starlynn C., additional, Williams, Carolyn, additional, Banh, Lynda, additional, Irby, Matthew, additional, Edwards, Leslie, additional, Storlie, Meghan, additional, Kohrs, Bryan, additional, Lilley, Graham W.J., additional, Smith, Stephen C., additional, Gradia, Scott, additional, Fuller, Chris K., additional, Skoble, Justin, additional, Garner, Elizabeth, additional, van Overbeek, Megan, additional, and Kanner, Steven B., additional

Published
2023
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17. Supplementary Table 1 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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18. Supplementary Methods from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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19. Supplementary Figure 3 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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20. Supplementary Figure 7 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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21. Supplementary Figure 5 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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22. Supplementary Table 2 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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23. Supplementary Figure 4 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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24. Supplementary Figure 1 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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25. Supplementary Figure 2 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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26. Supplementary Figure 6 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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27. Supplementary Table 3 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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29. HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans

Author

Ma, Yuanqing, primary, Joyce, Allison, additional, Brandenburg, Olivia, additional, Saatchi, Faeze, additional, Stevens, Christina, additional, Toffessi Tcheuyap, Vanina, additional, Christie, Alana, additional, Do, Quyen N., additional, Fatunde, Oluwatomilade, additional, Macchiaroli, Alyssa, additional, Wong, So C., additional, Woolford, Layton, additional, Yousuf, Qurratulain, additional, Miyata, Jeffrey, additional, Carrillo, Deyssy, additional, Onabolu, Oreoluwa, additional, McKenzie, Tiffani, additional, Mishra, Akhilesh, additional, Hardy, Tanner, additional, He, Wei, additional, Li, Daniel, additional, Ivanishev, Alexander, additional, Zhang, Qing, additional, Pedrosa, Ivan, additional, Kapur, Payal, additional, Schluep, Thomas, additional, Kanner, Steven B., additional, Hamilton, James, additional, and Brugarolas, James, additional

Published
2022
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30. A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas

Author

Foulks, Jason M., Carpenter, Kent J., Luo, Bai, Xu, Yong, Senina, Anna, Nix, Rebecca, Chan, Ashley, Clifford, Adrianne, Wilkes, Marcus, Vollmer, David, Brenning, Benjamin, Merx, Shannon, Lai, Shuping, McCullar, Michael V., Ho, Koc-Kan, Albertson, Daniel J., Call, Lee T., Bearss, Jared J., Tripp, Sheryl, Liu, Ting, Stephens, Bret J., Mollard, Alexis, Warner, Steven L., Bearss, David J., and Kanner, Steven B.

Published
2014
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39. Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

Author

Perez-Villar, Juan J., Whitney, Gena S., Sitnick, Mitchell T., Dunn, Robert J., Venkatesan, Srividhya, O'Day, Kathleen, Schieven, Gary L., Lin, Tai-An, and Kanner, Steven B.

Subjects
T cells -- Physiological aspects, Protein tyrosine kinase -- Physiological aspects, Protein binding -- Physiological aspects, Enzymes -- Regulation, Biological sciences, Chemistry
Abstract

Results indicate that kinases from protein tyrosine kinase families mediate phosphorylation of the T-cells activation linker, which involves the recruitment of the Vav guanine nucleotide exchange factor by Itk kinase. Data show that Vav specifically binds to the T-cells activation linker tyrosine residue Y-171.

Published
2002

40. Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease

Author

Wooddell, Christine I., primary, Blomenkamp, Keith, additional, Peterson, Ryan M., additional, Subbotin, Vladimir M., additional, Schwabe, Christian, additional, Hamilton, James, additional, Chu, Qili, additional, Christianson, Dawn R., additional, Hegge, Julia O., additional, Kolbe, John, additional, Hamilton, Holly L., additional, Branca-Afrazi, Maria F., additional, Given, Bruce D., additional, Lewis, David L., additional, Gane, Edward, additional, Kanner, Steven B., additional, and Teckman, Jeffrey H., additional

Published
2020
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41. Interleukin-2 induces Beta2-integrin-dependent signal transduction involving the focal adhesion kinase-related protein B (fakB)

Author

Brockdorff, Johannes, Kanner, Steven B., Nielsen, Mette, Borregaard, Niels, Geisler, Carsten, Svejgaard, Arne, and Odum, Niels

Subjects
Interleukin-2 -- Research, Transduction -- Research, Tyrosine -- Research, T cells -- Research, Science and technology
Abstract

[[Beta].sub.2] integrin molecules are involved in a multitude of cellular events, including adhesion, migration, and cellular activation. Here, we studied the influence of [[Beta].sub.2] integrins on interleukin-2 (IL-2)-mediated signal transduction in human CD[4.sup.+] T cell lines obtained from healthy donors and a leukocyte adhesion deficiency (LAD) patient. We show that IL-2 induces tyrosine phosphorylation of a 125-kDa protein and homotypic adhesion in [[Beta].sub.2] integrin (CD18)-positive but not in [[Beta].sub.2]-integrin-negative T cells. EDTA, an inhibitor of integrin adhesion, blocks IL-2-induced tyrosine phosphorylation of the 125-kDa protein but not other proteins in [[Beta].sub.2]-integrin-positive T cells. Likewise, a [[Beta].sub.2] integrin (CD18) antibody selectively inhibits induction of the 125-kDa phosphotyrosine protein, whereas cytokine-mediated tyrosine phosphorylation of other proteins is largely unaffected. Immunoprecipitation experiments indicate that the IL-2-induced 125-kDa phosphotyrosine protein is the focal adhesion kinase-related protein B (fakB). Thus, IL-2 induces strong tyrosine phosphorylation of fakB in [[Beta].sub.2]-integrin-positive but not in [[Beta].sub.2]-integrin-negative T cells, and CD18 mAb selectively blocks IL-2-induced fakB-tyrosine phosphorylation in [[Beta].sub.2]-integrin-positive T cells. In parallel experiments, IL-2 does not induce or augment tyrosine phosphorylation of [p125.sup.FAK]. In conclusion, our data indicate that IL-2 induces [[Beta].sub.2]-integrin-dependent signal transduction events involving the tyrosine kinase substrate fakB.

Published
1998

43. Activation of murine T-cells via phospholipase-C-gamma-1-associated protein tyrosine phosphorylation is reduced with aging

Author

Grossmann, Angelika, Rabinovitch, Peter S., Kavanagh, Terrence J., Jinneman, John C., Gilliland, Lisa K., Ledbetter, Jeffrey A., and Kanner, Steven B.

Subjects
T cells -- Physiological aspects, Tyrosine metabolism -- Research, Phospholipases -- Physiological aspects, Aging -- Physiological aspects, Health, Seniors
Abstract

Cross-linking of the T-cell receptor (CD3) induces activation of tyrosine kinases and the subsequent phosphorylation of intracellular protein substrates. We examined whether early events in signal transduction through CD3 or CD3 x CD4 receptor ligation were altered in aged murine lymphocytes. Both calcium mobilization and tyrosine phosphorylation of phospholipase C[gamma]1 (PLC[gamma]1) were decreased in T-lymphocytes from old mice. In addition, there was less tyrosine phosphorylation of a 35/36 kDa protein both in whole cell lysates and in PLC[gamma]1 immunoprecipitates from old mice. This 35/36 kDa phosphoprotein binds specifically to the SH2 domains of PLC1. Using a fission protein containing the SH2 domains of PLC[gamma]1 and human IgG1 heavy chain, we identified three additional proteins that bind to the SH2 domains which were tyrosine phosphorylated following CD3 x CD4 ligation to a lesser degree with age. The tyrosine phosphorylation of two phosphorylated binding to a fusion protein consisting of the SH2 domains of GAP (ras GTPase-activating protein) and human IgG1 heavy chain was also reduced with aging. The observed binding to SH2 domains was thiol redox sensitive. Thus, decreases in antioxidants with age may be responsible for inhibitory effects on PLC[gamma]1-phosphatidylinositol signaling through redox regulation of tyrosine phosphoproteins.

Published
1995

44. Beta2-Integrin LFA-1 signaling through phospholipase C-gamma1 activation

Author

Kanner, Steven B., Grosmaire, Laura S., Ledbetter, Jeffrey A., and Damle, Nitin K.

Subjects
Phospholipases -- Research, Proteins -- Crosslinking, T cells -- Receptors, Monoclonal antibodies -- Analysis, Science and technology
Abstract

LFA-1 is linked to the tyrosine kinase signaling pathway that induces tyrosine phosphorylation and activation of phospholipase C-gamma1 (PLC-gamma 1). Integrin beta-chain (CD18) crosslinking freely stimulated downstream mobility of intracellular Ca2+ and strongly induced T-cell antigen receptor (TCR)-induced Ca2+ flux with an increase in amplitude and kinetics. Beta2-integrin signaling through this path was totally inhibited by herbimycin A and was prevented by TCR modulation. Tyrosine phosphorylation of an 80-kDa protein substrate was enhanced after CD18 crosslinking, but it was not TCR-dependent.

Published
1993

47. HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Author

Wong, So C., primary, Cheng, Weijun, additional, Hamilton, Holly, additional, Nicholas, Anthony L., additional, Wakefield, Darren H., additional, Almeida, Aaron, additional, Blokhin, Andrei V., additional, Carlson, Jeffrey, additional, Neal, Zane C., additional, Subbotin, Vladimir, additional, Zhang, Guofeng, additional, Hegge, Julia, additional, Bertin, Stephanie, additional, Trubetskoy, Vladimir S., additional, Rozema, David B., additional, Lewis, David L., additional, and Kanner, Steven B., additional

Published
2018
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49. Selective Itk inhibitors block T-cell activation and murine lung inflammation

Author

Tai-An Lin, McIntyre, Kim W., Das, Jadabandhu, Chunjian Liu, O'Day, Kathleen D., Penhallow, Becky, Chen-Yi Hung, Whitney, Gena S., Shuster, David J., XiaiXia Yang, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H., Lin, James, Moquin, Robert V., Furch, Joseph A., Kamath, Amrita V., Hongjian Zhang, Marathe, Punit H., Perez-Villar, Juan J., Doweyko, Arthur, Killar, Loran, Dodd, John H., Barrish, Joel C., Wityak, John, and Kanner, Steven B.

Subjects
Protein tyrosine kinase -- Spectra, T cells -- Analysis, Biological sciences, Chemistry
Abstract

The two potent and selective Itk inhibitors that blocked T-cell activation in vitro and suppressed inflammation in a murine asthma/allergy model are described. The analysis represent the first description of selective inhibitors to probe human Itk function and its associated pathway, and support the hypothesis that Itk is a therapeutic target for immunosuppressive and inflammatory diseases.

Published
2004

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