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19 results on '"Kannappan, Sunand"'

8. More Than a Eureka Moment: Undergraduate Students' Reflective Understanding of Science Inquiry in a Citizen Science Project.

Author

Becker, Sandra, Clark, Douglas, Gupta, Mehul, Kannappan, Sunand, Wong, Britney, Hernandez-Zavaleta, Enrique, and Guo, Eddie

Subjects
UNDERGRADUATES, CITIZEN science, SCIENTIFIC knowledge
Abstract

Citizen science provides an opportunity for the public to contribute to, engage in and learn about science in the context of researchers' construction of scientific knowledge. The following paper explores four undergraduate students' understanding of science inquiry in relation to a citizen science project they developed for high school participants. The findings show that through their involvement in the study and the production of this article, which included a reflective writing and discursive component, the undergraduate students were able to broaden and deepen their notions of science inquiry. The students' development suggests that conceptualizing and implementing a citizen science project with high school students provides a unique platform not just for students' but also for teachers' development in the understanding of science inquiry. [ABSTRACT FROM AUTHOR]

Published
2022

18. In VitroInvestigation Demonstrates IGFR/VEGFR Receptor Cross Talk and Potential of Combined Inhibition in Pediatric Central Nervous System Atypical Teratoid Rhabdoid Tumors

Author

Obaid, Halah, Kannappan, Sunand, Gupta, Mehul, Ruan, Yibing, Zhang, Chunfen, Bose, Pinaki, and Narendran, Aru

Abstract

Background: Atypical teratoid rhabdoid tumor of the central nervous system (CNS ATRT) is a malignancy that commonly affects young children. The biological mechanisms contributing to tumor aggressiveness and resistance to conventional therapies in ATRT are unknown. Previous studies have shown the activity of insulin like growth factor-I receptor (IGF-1R) in ATRT tumor specimens and cell lines. IGF-1R has been shown to cross-talk with other receptor tyrosine kinases (RTKs) in a number of cancer types, leading to enhanced cell proliferation. Objective: This study aims to evaluate the role of IGF-1 receptor cross-talk in ATRT biology and the potential for therapeutic targeting. Methods: Cell lines derived from CNS ATRT specimens were analyzed for IGF-1 mediated cell proliferation. A comprehensive receptor tyrosine kinase (RTK) screen was conducted following IGF-1 stimulation. Bioinformatic analysis of publicly available cancer growth inhibition data to identify correlation between IC50 of a VEGFR inhibitor and IGF-1R expression. Results: Comprehensive RTK screen identified VEGFR-2 cross-activation following IGF-1 stimulation. Bioinformatics analysis demonstrated a positive correlation between IC50 values of VEGFR inhibitor Axitinib and IGF-1R expression, supporting the critical influence of IGF-1R in modulating response to anti-angiogenic therapies. Conclusion: Overall, our data present a novel experimental framework to evaluate and utilize receptor cross-talk mechanisms to select effective drugs and combinations for future therapeutic trials in ATRT.

Published
2020
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