333 results on '"Kannan, Srinivasaraghavan"'
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2. Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
3. Modulation of PETase active site flexibility and activity on morphologically distinct polyethylene terephthalate substrates by surface charge engineering
4. Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
5. CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma
6. Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
7. High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
8. Modulation of Ideonella sakaiensis PETase active site flexibility and activity on morphologically distinct substrates by surface charge engineering
9. List of contributors
10. Stapled peptidomimetic therapeutics
11. Expanding the DNA editing toolbox: Novel lambda integrase variants targeting microalgal and human genome sequences
12. Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor
13. An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin
14. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11
15. Expanding the DNA editing toolbox: novel lambda integrase variants targeting microalgal and human genome sequences.
16. Elucidating the Effect of Polyethylene Terephthalate Chain Structure on Its Enzymatic Degradation Behavior
17. Molecular Dynamics and Advanced Sampling Simulations of Nucleic Acids
18. Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges
19. Disrupting the Dok3–Card9 Interaction with Synthetic Peptides Enhances Antifungal Effector Functions of Human Neutrophils
20. Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
21. A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
22. Molecular descriptors suggest stapling as a strategy for optimizing membrane permeability of cyclic peptides.
23. Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor.
24. A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays
25. Data from TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors
26. Supplementary Figures from TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors
27. Supplementary Tables from TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors
28. Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
29. JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1
30. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
31. Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
32. Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein
33. Molecular Dynamics and Advanced Sampling Simulations of Nucleic Acids
34. Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein
35. Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules
36. Activation of p53: How phosphorylated Ser15 triggers sequential phosphorylation of p53 at Thr18 by CK1δ
37. Abstract 5239: Switching inhibitor class overcomes crizotinib resistance in a MET fusion-positive NSCLC with a novel acquired MET G1090A mutation
38. Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
39. Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h
40. Computer- and structure-based lead design for epigenetic targets
41. Src activates retrograde membrane traffic through phosphorylation of GBF1
42. AKT signaling in ERBB2-amplified breast cancer
43. Molecular Dynamics and Advanced Sampling Simulations of Nucleic Acids
44. Author response: Src activates retrograde membrane traffic through phosphorylation of GBF1
45. Update on the Development of MNK Inhibitors as Therapeutic Agents
46. Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling
47. A chemical biology approach reveals a dependency of glioblastoma on biotin distribution
48. High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer.
49. Engineered RebH Halogenase Variants Demonstrating a Specificity Switch from Tryptophan towards Novel Indole Compounds
50. Corrigendum to 'Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ‐domain motif interaction and identification of putative functional modules' [FEBS Open Bio 4 (2014) 571–583]
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