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1. Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

Author

Wenjing Wang, Renzheng Guan, Ziran Liu, Feng Zhang, Rui Sun, Sitong Liu, Xiaoyan Shi, Zhilei Su, Rongxiang Liang, Kangyu Hao, Zhaoguo Wang, and Xianming Liu

Subjects
human bocavirus, acute respiratory infections, viral infection, bacteria, Stenotrophomonas maltophilia, multiplex real-time PCR, Microbiology, QR1-502
Abstract

Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection methods and sampling criteria, determining the viral and bacterial etiology of HBoV infection using multiplex real-time PCR is yet to be reported. Herein, we aimed to further explore the pathogenicity of HBoV in patients with ARI by screening the viral and bacterial infections in children with ARI in Qingdao and comparing the epidemiological, clinical characteristics, and etiological results. Human bocavirus was identified in 28.1% of the samples, and further sequencing analysis of the detected HBoV confirmed 96.4% as HBoV1. The rate of HBoV as a single viral infection was 75%, and the rate of coinfection with bacteria was 66.1%, suggesting the need for continued monitoring of HBoV in children with ARIs. Clinical characterization suggested that HBoV infection may affect the function of organs, such as the liver, kidney, and heart, and the blood acid–base balance. Additionally, it is essential to promote awareness about the importance of disinfection and sterilization of the hospital environment and standardizing operations. The interactions between HBoV and other pathogens remain to be investigated in further detail in the future.

Published
2022
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2. Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults

Author

Jia Luo, Honghan Ge, Jing Sun, Kangyu Hao, Wenqin Yao, and Dongfeng Zhang

Subjects
sleep disorders, sleep duration, dietary ω-3 fatty acids, dietary ω-6 fatty acids, dose–response relationship, Nutrition. Foods and food supply, TX341-641
Abstract

The relationship between ω-3 and ω-6 fatty acids consumption and sleep disorders or duration are controversial. Therefore, we used the data of the National Health and Nutrition Examination Survey 2007–2016 in this cross-sectional study to explore their relationships. ω-3 and ω-6 fatty acids consumption was assessed using two 24 h dietary recall interviews. Sleep disorders and sleep duration were based on self-reported data. Logistic regression models and restricted cubic spline analyses were used. Compared with tertile one, the odds ratios (ORs) and 95% confidence intervals (CIs) of sleep disorders for the second tertile of ω-6 fatty acid intake and the highest tertile of ω-6:ω-3 ratio were 1.30 (1.04–1.62) and 1.36 (1.08–1.70), respectively. Inverse U-shaped and linear dose–response relationships were observed between dietary ω-6 fatty acid intake and ω-6:ω-3 ratio and sleep disorders, respectively. In addition, ω-3 fatty acid consumption was adversely related to sleep disorders in men and the OR (95% CI) was 0.68 (0.49–0.95). Compared with normal sleep duration, ω-3 fatty acid consumption was negatively related to very short, short, and long sleep duration risk. The relative risk ratios (RRRs) were 0.53 (0.35–0.81), 0.79 (0.67–0.93), and 0.81 (068–0.98), respectively. The RRR of very short sleep for ω-6 fatty acid consumption was 0.57 (0.45–0.73). Our study indicates that ω-6 fatty acid consumption and the ω-6:ω-3 ratio are positively associated with the risk of sleep disorders, while the negative association between ω-3 fatty acids and sleep disorders may exist only in men. Furthermore, ω-3 and ω-6 fatty acid consumption are negatively related to the risk of non-normal sleep duration.

Published
2021
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3. Relationships between urinary antimony concentrations and depressive symptoms in adults

Author

Jia Luo, Kangyu Hao, Tianhao Zhang, Dongfeng Zhang, Zixuan Wang, and Honghan Ge

Subjects
Adult, Antimony, Disease status, medicine.medical_specialty, Environmental Engineering, National Health and Nutrition Examination Survey, Health, Toxicology and Mutagenesis, Urinary system, Population, chemistry.chemical_element, Logistic regression, Internal medicine, Environmental Chemistry, Medicine, Humans, education, Depressive symptoms, Depression (differential diagnoses), education.field_of_study, business.industry, Depression, Public Health, Environmental and Occupational Health, General Medicine, General Chemistry, Nutrition Surveys, Pollution, Cross-Sectional Studies, chemistry, Female, business, Cadmium
Abstract

Background Antimony is widely used in industrial production. The general population may be exposed to long-term low-dose antimony, and there are no studies on antimony and depression symptoms. This study aims to explore the relationships between urinary antimony concentrations and depressive symptoms in adults. Methods We conducted a cross-sectional study using data from U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2016 for urinary antimony (N = 8538). Depressive symptoms were assessed through Patient's Health Questionnaire (PHQ-9). In order to determine the relationships between urinary antimony concentrations and depressive symptoms, binary logistic regression model and restricted cubic spline were used. Dominance analysis was used to explore the relative importance between variables associated with depressive symptoms. Results There was a significant positive relationship between urinary antimony concentrations and depressive symptoms in the general population, and OR with 95% CI was 1.72 (1.15, 2.60). This relationship also occurred in participants without disease status, and OR with 95% CI was 2.05 (1.10, 3.82). After stratified gender, the urinary antimony concentrations were positively correlated with depressive symptoms in the highest tertiles of female participants, and OR with 95% CI was 1.74 (1.06, 2.86). After adjusted urinary lead, arsenic, cadmium, and mercury as covariates, the result was still statistically significant, and OR with 95% CI was 1.83 (1.23, 2.72). Restricted cubic spline showed a nonlinear positive relationship between urinary antimony and depressive symptoms. Based on the result of dominance analysis, the relative importance of urinary antimony concentration accounted for 3.58%. Conclusion This study indicated that urinary antimony was positively related to depressive symptoms, especially in female.

Published
2021

4. Associations of urinary bisphenol A and its alternatives bisphenol S and F concentrations with depressive symptoms among adults

Author

Jing Sun, Kangyu Hao, Zhaoguo Wang, Jia Luo, and Honghan Ge

Subjects
Adult, Male, endocrine system, medicine.medical_specialty, Environmental Engineering, National Health and Nutrition Examination Survey, Health, Toxicology and Mutagenesis, Urinary system, 0208 environmental biotechnology, Population, 02 engineering and technology, Urine, 010501 environmental sciences, urologic and male genital diseases, Logistic regression, 01 natural sciences, Phenols, Internal medicine, medicine, Humans, Environmental Chemistry, Sulfones, Benzhydryl Compounds, education, Aged, 0105 earth and related environmental sciences, education.field_of_study, Depression, urogenital system, business.industry, Public Health, Environmental and Occupational Health, General Medicine, General Chemistry, Odds ratio, Middle Aged, Nutrition Surveys, Pollution, Confidence interval, 020801 environmental engineering, Patient Health Questionnaire, Female, business, hormones, hormone substitutes, and hormone antagonists
Abstract

Background Bisphenol S (BPS) and bisphenol F (BPF), as substitutes for bisphenol A (BPA), are synthetic compounds detected increasingly frequently in plastics and resins. BPA, BPS, and BPF are endocrine disruptors with unclear effects on depressive symptoms. This study aims to evaluate the effects of these compounds on depressive symptoms in adults. Methods We used data from the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2016 for BPA (N = 7,085) and NHANES 2013–2016 for BPS and BPF (N = 2,707). BPA, BPS and BPF were detected in urine samples. Depressive symptoms were assessed with a nine-item patient health questionnaire (PHQ-9). Logistic regression models were used to investigate the effects of urinary BPA, BPS, and BPF concentrations on depressive symptoms. Results In the general population, no significant association was observed between urinary BPA, BPS, and BPF and depressive symptoms. However, in stratified analyses, urinary BPS was positively associated with depressive symptoms in men (odds ratio [OR], 2.90; 95% confidence interval [CI], 1.13–7.47). In elderly men (≥60 years old), urinary BPA and BPS were positively correlated with depressive symptoms with ORs (95% CIs) of 5.53 (1.55–19.70) and 28.89 (4.23–192.75), respectively. In addition, urinary BPS was negatively associated with depressive symptoms (OR, 0.16; 95% CI, 0.04–0.59) in elderly women (≥60 years old). Conclusions This study indicated that exposure to BPA and BPS was positively associated with depressive symptoms, especially in men. However, BPS was negatively associated with depressive symptoms in elderly women.

Published
2021

5. Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults

Author

Kangyu Hao, Honghan Ge, Dongfeng Zhang, Jing Sun, Wenqin Yao, and Jia Luo

Subjects
Adult, Male, Sleep Wake Disorders, Time Factors, Adolescent, National Health and Nutrition Examination Survey, Physiology, 030204 cardiovascular system & hematology, Logistic regression, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Fatty Acids, Omega-6, Fatty Acids, Omega-3, dietary ω-3 fatty acids, Humans, Medicine, TX341-641, chemistry.chemical_classification, Consumption (economics), Nutrition and Dietetics, Nutrition. Foods and food supply, business.industry, Fatty acid, Odds ratio, Middle Aged, Sleep in non-human animals, Diet Records, Confidence interval, Diet, Cross-Sectional Studies, dietary ω-6 fatty acids, chemistry, Relative risk, dose–response relationship, sleep duration, Female, sleep disorders, Sleep, business, 030217 neurology & neurosurgery, Food Science
Abstract

The relationship between ω-3 and ω-6 fatty acids consumption and sleep disorders or duration are controversial. Therefore, we used the data of the National Health and Nutrition Examination Survey 2007–2016 in this cross-sectional study to explore their relationships. ω-3 and ω-6 fatty acids consumption was assessed using two 24 h dietary recall interviews. Sleep disorders and sleep duration were based on self-reported data. Logistic regression models and restricted cubic spline analyses were used. Compared with tertile one, the odds ratios (ORs) and 95% confidence intervals (CIs) of sleep disorders for the second tertile of ω-6 fatty acid intake and the highest tertile of ω-6:ω-3 ratio were 1.30 (1.04–1.62) and 1.36 (1.08–1.70), respectively. Inverse U-shaped and linear dose–response relationships were observed between dietary ω-6 fatty acid intake and ω-6:ω-3 ratio and sleep disorders, respectively. In addition, ω-3 fatty acid consumption was adversely related to sleep disorders in men and the OR (95% CI) was 0.68 (0.49–0.95). Compared with normal sleep duration, ω-3 fatty acid consumption was negatively related to very short, short, and long sleep duration risk. The relative risk ratios (RRRs) were 0.53 (0.35–0.81), 0.79 (0.67–0.93), and 0.81 (068–0.98), respectively. The RRR of very short sleep for ω-6 fatty acid consumption was 0.57 (0.45–0.73). Our study indicates that ω-6 fatty acid consumption and the ω-6:ω-3 ratio are positively associated with the risk of sleep disorders, while the negative association between ω-3 fatty acids and sleep disorders may exist only in men. Furthermore, ω-3 and ω-6 fatty acid consumption are negatively related to the risk of non-normal sleep duration.

Published
2021

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