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Abstract Background Trigger thumb is a prevalent hand condition observed in children, and its management remains a topic of considerable debate, ranging from mere observation to surgical intervention. In recent times, there has been a growing interest in exploring nonoperative treatments as alternatives to surgical procedures for managing pediatric trigger thumb. Gaining insight into the prevalence of spontaneous resolution in pediatric trigger thumb is of paramount importance. However, the literature presents a wide variation in estimates regarding the prevalence of this spontaneous resolution, highlighting the need for further investigation and consensus. The aim of this review was to estimate the overall prevalence of spontaneous resolution among pediatric trigger thumb. Methods This study meticulously followed the PRISMA guidelines and registered in the PROSPERO. The PubMed, Embase, and Cochrane Library databases were searched for all relevant studies up to May 2024.Inclusion criteria were studies reported only observation spontaneous resolution pediatric trigger thumb, aged up to 14 years, reported at least 10 thumbs and followed up time at least 3 months. Confounded intervention treatment measure studies were excluded. To synthesize the prevalence rates from individual studies, we employed a random-effects meta-analysis. In order to uncover the sources of heterogeneity and to compare prevalence estimates across different groups, we performed sensitivity and subgroup analyses. To meticulously evaluate the quality of the included studies, the Joanna Briggs Institute’s quality assessment checklist was employed. Furthermore, to assess the heterogeneity among the studies, both Cochran’s Q test and the I² statistic were utilized. Results A total of eleven studies were included for the final analysis, with 599 pediatric trigger thumbs. Our final meta-analysis showed that more than one-third of these pediatric trigger thumb cases resolved spontaneously, with a resolution rate of 43.5% (95% CI 29.6–58.6). Subgroup analyses showed that in terms of age at the first visit, the prevalence of spontaneous resolution in the less than 24 months group and in the 24 months or older group was 38.7%(95% CI 18.1–64.4)and 45.8%(95% CI 27.4–65.4), respectively. There was no significant difference between the two groups(P = 0.690). When analyzing follow up time, the prevalence of spontaneous resolution in the 24 months or longer group and in the less than 24 months group was 58.9%(95% CI 41.6–74.2)and 26.8%(95% CI 14.7–43.8), respectively.There was significant statistical differences between the two groups(P = 0.009). Based on the initial severity of interphalangeal (IP) joint flexion contracture, the prevalence of spontaneous resolution in the 30 degrees or less group and in the other measurements group was 54.1%(95% CI 31.5–75.1)and 37.1%(95% CI 21.9–55.4), respectively.There was no significant difference between the two groups(P = 0.259). Conclusion Our study demonstrates that a significant proportion of pediatric trigger thumbs resolve spontaneously. This finding highlights the benefits of early observation in managing this condition. By prioritizing non-operative observation, both parents and surgeons are better equipped to make informed decisions regarding the treatment of pediatric trigger thumb, potentially reducing the need for surgical intervention.

China is a country in the world with the serious environmental pollution of coal mine “three wastes” (solid, liquid, gas). A lot of in-depth research and practice has been carried out on the utilization and treatment of “three wastes”. However, there are still many problems such as imperfect standards and norms, small scale of treatment and unsound technology. In order to solve the problem of synergistic development of low-cost geological storage of large-scale “three wastes” and ecological environment in China’s coal mines, on the basis of the definition of geological storage in other countries, the connotation of geological storage in China has been expanded. The progress and current status of research on the geological storage of “three wastes” are analyzed. Literature and patents related to the geological storage of “three wastes” at home and abroad are reviewed. The problems faced by China in carrying out the geological storage of “three wastes” and the suggestions for further development are put forward. It is pointed out that the main problem faced by the geological storage of “three wastes” in China is the inadequacy of the standards and regulations in the field of environment, especially the extensive lack of standards for the deep-well injection of waste liquids. The systematic research has shown that the research institutions in China are paying increasing attention to research in the field of the geological storage of the “three wastes”, and that the results of the research account for a high percentage of research in the world. China’s coal mine “three wastes” geological storage and ecological environment synergistic development awareness and system is being formed. However, there is insufficient support for research on the large-scale geological storage of “three wastes”, the cyclic system of geological storage of “three wastes” in the whole cycle of coal mining, and the synergistic relationship between CO2 capture, utilization and storage (CCUS) technology and the ecological environment. This seriously restricts the large-scale implementation and application of the concepts, technologies and projects of geological storage. China should expeditiously strengthen the scientific and technological research and development of coal mine “three wastes” geological storage technology and ecological environment synergistic development. Through the establishment of improved standards and norms, increased technological research and development, and strengthened environmental supervision and other measures, the green and sustainable development in China’s coal mines is promoted, helping the China’s “dual-carbon” goal to be realized.

Abstract Objectives To compare the characteristics of body compositions between metabolic syndrome (MetS) and frailty, and determine the independent and overlapping of MetS and frailty with postoperative complications among older patients with gastric cancer. Design A prospectively observational study. Setting and Participants Two hundred and eighty six older patients from 60 to 80 years undergoing radical gastrectomy for the first time. Measurements MetS was diagnosed by the criteria from the 2020 edition of Chinese guideline for the prevention and treatment of type 2 diabetes mellitus, and frailty was defined by frailty phenotype. An InBody770 impedance analyzer was used to measure body compositions and with 10 fat‐ and muscle‐related indicators being included in this study. Based on the presence of frailty and MetS, patients were divided into the frailty group, MetS group, frailty+MetS group, and normal group, and the body compositions indicators of these groups were compared. Clavien–Dindo classification was used to grade the severity of postoperative complications. Univariate and multivariate regression models were performed to explore the independent and joint association of MetS and frailty with postoperative complications. Results The incidence rate of MetS, frailty, and frailty+MetS being 20.3%, 15.7%, and 4.2% respectively. Compared with the normal group, both fat and muscle compositions were decreased significantly in the frailty group (p 0.05). In contrast, except SVR, the other indicators of the MetS group were higher than the normal group (p 0.05). There was an association of frailty with postoperative total (OR = 3.068, 95% CI: 1.402–6.713) and severe (OR = 9.423, 95% CI: 2.725–32.589) complications, but no association was found of MetS alone. MetS coexisting with frailty was associated with the highest risk of both total (OR = 3.852, 95% CI: 1.020–14.539) and severe (OR = 12.096, 95% CI: 2.183–67.024) complications. Conclusions Both frailty and MetS coexisting with frailty had adverse effects on postoperative complications, which appeared greatly different characteristics in body compositions and therefore reinforced the importance of targeted nutritional or metabolic intervention. Although MetS alone were not significantly associated with postoperative complications, it is essential to focus on the causal relationship and development trend between MetS and frailty to prevent MetS from shifting into frailty, considering the highest risk in their coexistence state.

Abstract Mastering the self‐organization of nanoparticle morphologies is pivotal in soft matter physics and film growth. Silicon dioxide (SiO2) nanoparticles are an archetypical model of nanomotor in soft matter. Here, the emphasis is on the self‐organizing behavior of SiO2 nanoparticles under extreme conditions. It is unveiled that manipulating the states of the metal substrate profoundly dictates the motion characteristics of SiO2 nanoparticles. This manipulation triggers the emergence of intricate morphologies and distinctive patterns. Employing a reaction‐diffusion model, the fundamental roles played by Brownian motion and Marangoni‐driven motion in shaping fractal structures and radial Turing patterns are demonstrated, respectively. Notably, these radial Turing patterns showcase hyperuniform order, challenging conventional notions of film morphology. These discoveries pave the way for crafting non‐equilibrium morphological materials, poised with the potential for self‐healing, adaptability, and innovative applications.

Abstract The frequent wildfires and extensive biochar application accumulate biochar colloids in soils. The transport of biochar colloids may influence the release of soil dissolved organic matter (DOM) due to their high mobility and active surface, posing a detrimental impact on carbon cycle, pollutants behaviors, and water quality. Here, we examined the effect of pristine and aged biochar colloids on soil DOM release in three types of soils (black soil, fluvisol, and paddy soil) through adsorption and column experiments combined with fluorescence excitation/emission matrix spectroscopy (EEM) and fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Adsorption experiment showed that biochar exhibited little effect on soil DOM release, while transport experiment indicated that the downward movement of both pristine and aged biochar colloids significantly enhanced the release of soil DOM, especially black soil and fluvisol. EEM spectra indicated that a humic acid-like substance with large molecular weights was the primary DOM that enhanced release from black soil (10.9–12.0% enhancement) and fluvisol (6–8% enhancement) during biochar colloid transport. Condensed aromatic-like (22.8% and 19.4%) and tannin-like (18.4% and 18.9%) compounds are the primary molecules correlated to the enhanced release of humic acid-like substances. Although chemical aging resulted in a more negative surface of aged biochar colloids and slightly enhanced biochar colloid transport (up to 7.0%), it showed no distinct effect on the release of soil DOM. This study indicates that biochar colloids may cause an increase in DOM release when irrigation and rainfall occur, and more attention should be paid to the environmental impacts of biochar colloids from intensive biochar application and wildfires. Graphical Abstract

Abstract The development of stable and efficient ligands is of vital significance to enhance the catalytic performance of carbonylation reactions of alkenes. Herein, an aryldiphosphine ligand (L11) bearing the [Ph2P(ortho-C6H4)]2CH2 skeleton is reported for palladium-catalyzed regioselective carbonylation of alkenes. Compared with the industrially successful Pd/1,2-bis(di-tert-butylphosphinomethyl)benzene catalyst, catalytic efficiency catalyzed by Pd/L11 on methoxycarbonylation of ethylene is obtained, exhibiting better catalytic performance (TON: >2,390,000; TOF: 100,000 h−1; selectivity: >99%) and stronger oxygen-resistance stability. Moreover, a substrate compatibility (122 examples) including chiral and bioactive alkenes or alcohols is achieved with up to 99% yield and 99% regioselectivity. Experimental and computational investigations show that the appropriate bite angle of aryldiphosphine ligand and the favorable interaction of 1,4-dioxane with Pd/L11 synergistically contribute to high activity and selectivity while the electron deficient phosphines originated from electron delocalization endow L11 with excellent oxygen-resistance stability.

To address the problems of slow convergence, low search accuracy, and easy fall into local optimum, and generating a large number of infeasible solutions when solving the 0–1 Knapsack Problem, which makes it difficult to obtain the optimal solution scheme, in this paper, we present a greedy induced mutation method for locally optimal solutions, namely, an improved Shuffled Frog Leaping Algorithm (Shuffled Frog Leaping Algorithm based on Greedy Algorithm and Mutation, SFLA-GA-M). First, the proposed algorithm adjusts the population generation of individuals in the SFLA to avoid infeasible solutions, thereby optimizing the local update strategy. Secondly, an induced mutation mechanism that incorporates both greedy algorithms and genetic algorithms is introduced to enhance the search accuracy of the algorithm. Finally, ten classical 0–1 Knapsack Problem cases were selected to prove the feasibility and robustness of the proposed SFLA-GA-M by comparing with other two SFLA variants, which are MDSFLA, DSFLA. Meanwhile, to further verify the performance of the SFLA-GA-M, two classical 0–1 KPs with multi-dimensional test cases were introduced by compared with other five algorithm: DEA, PSO, GA, BMA and IFMA, respectively. The experimental results show that SFLA-GA-M has achieved stronger convergence and stability compared to DEA, PSO, and GA, and it has displayed better search efficiency and a superior global search capability than BMA and IFMA in solving large-sized 0–1 Knapsack Problem.

Reinforced concrete beam bridges are usually retrofitted by a steel plate or FRP. However, these two methods tend to result in disadvantages, e.g., construction complexity and debonding failure, owing to the corresponding material properties. In this study, a steel- and CFRP-based method is proposed to achieve the merits of typical retrofitting methods by combining a CFRP plate, a steel plate, and angle steel. To investigate the effect of the cooperative strengthening, six full-scale beam specimens were designed and are evaluated through a monotonic four-point bending test. The failure mode, load–deflection relationship, critical parameters, and crack development are systematically and sequentially analyzed. Finally, a predicting method is proposed to calculate the flexural capacity. The retrofitted beam is characterized by an acceptable load-bearing capacity and deformation capacity. With continuous retrofitting, the crack load and ultimate load can be improved up to 84.9% and 4.41 times, respectively. The steel plate and angle steel function in both the load bearing and the anchorage to the CFRP plate contributes more to the ultimate bearing capacity after the steel components yield. Finally, a calculating model is shown to accurately predict the ultimate bearing capacity after retrofitting, with an average error of 4.03%.

The heterogeneous composition of fungi plays an indispensable role in the foundation of the multifunctionalities of ecosystems within drylands. The precise mechanisms that govern fluctuations in soil fungal assemblages in dryland ecosystems remain incompletely elucidated. In this study, biological soil crusts (biocrusts) at different successional stages in the Gurbantunggut Desert were used as substrates to examine the characteristics and driving factors that influence fungal abundance and community dynamics during biocrust development using qPCR and high-throughput sequencing of the ITS2 region. The findings showed that the physicochemical properties changed significantly with the development of biocrusts. In particular, total nitrogen increased 4.8 times, along with notable increases in ammonium, total phosphorus (2.1 times) and soil organic carbon (6.5 times). Initially, there was a rise in fungal abundance, which was subsequently followed by a decline as the biocrust developed, with the highest abundance detected in lichen crust (2.66 × 107 copies/g soil) and the lowest in bare sand (7.98 × 106 copies/g soil). Ascomycetes and Basidiomycetes emerged as dominant phyla, collectively forming 85% of the fungal community. As the biocrust developed, noticeable alterations occurred in fungal community compositions, resulting from changes in the relative proportions of Dothideomycetes, Lecanoromycetes and unclassified ascomycetes. Nitrogen, phosphorus, organic carbon content, and pH of biocrusts were identified as direct or indirect regulators of fungal abundance and community structure. The complexity of fungal networks increased as biocrusts developed as revealed by network analysis, but reduced in the stability of fungal communities within algal and lichen crusts. Keystone species within the fungal community also underwent changes as biocrust developed. These results suggested that shifts in interspecies relationships among fungi could further contribute to the variation in fungal communities during the development of biocrusts.

In order to improve the cutting performance of the hourglass worm gear hob and improve the cutting conditions of the teeth on both sides, it is necessary to constrain the absolute value of the rake angle of each tooth to be small and control the balance of the rake angles on the left and right sides. Based on the principle of enveloping tooth surface formation (Dong, 1989; Wu, 2009), this paper proposes a method of forming a spiral groove rake face with a variable transmission ratio, so that the rake face of each tooth is formed in segments to achieve the design requirements of small absolute value and balance on both sides. Taking the basic worm speed ω of the hob, the moving speed v of the machine tool cutter, and the installation offset Δx of the cutter as experimental factors, taking the rake angle on both sides of five teeth of the hob as response values, a three-factor three-level response surface analysis method is used to establish mathematical models between each experimental factor and the rake angle on both sides, and analyze the interaction between each factor. The results show that: The order of influence of the three selected factors on the rake angle on both sides is: basic worm speed, machine tool cutter moving speed, cutter installation offset; optimize and obtain the optimal parameter combination for each of five teeth in a spiral groove, perform simulation processing and measure rake angle. The results show that the rake angles on both sides of five teeth are controlled within ±0.3°, which is 94% lower than that when five teeth are processed simultaneously with a fixed transmission ratio. This indicates that rake faces of small rake angle can be designed by optimizing processing parameters, which is conducive to improving and balancing the cutting performance of hobs.

The widespread use of Light Detection and Ranging (LiDAR) technology has led to a surge in three-dimensional point cloud data; although, it also poses challenges in terms of data storage and indexing. Efficient storage and management of LiDAR data are prerequisites for data processing and analysis for various LiDAR-based scientific applications. Traditional relational database management systems and centralized file storage struggle to meet the storage, scaling, and specific query requirements of massive point cloud data. However, NoSQL databases, known for their scalability, speed, and cost-effectiveness, provide a viable solution. In this study, a 3D point cloud indexing strategy for mobile LiDAR point cloud data that integrates Hilbert curves, R*-trees, and B+-trees was proposed to support MongoDB-based point cloud storage and querying from the following aspects: (1) partitioning the point cloud using an adaptive space partitioning strategy to improve the I/O efficiency and ensure data locality; (2) encoding partitions using Hilbert curves to construct global indices; (3) constructing local indexes (R*-trees) for each point cloud partition so that MongoDB can natively support indexing of point cloud data; and (4) a MongoDB-oriented storage structure design based on a hierarchical indexing structure. We evaluated the efficacy of chunked point cloud data storage with MongoDB for spatial querying and found that the proposed storage strategy provides higher data encoding, index construction and retrieval speeds, and more scalable storage structures to support efficient point cloud spatial query processing compared to many mainstream point cloud indexing strategies and database systems.

The presence of abundant spatio-temporal information based on the location of mobile objects in publicly accessible GPS mobile devices makes it crucial to collect, analyze, and mine such information. Therefore, it is necessary to index a large volume of trajectory data to facilitate efficient trajectory retrieval and access. It is difficult for existing indexing methods that primarily rely on data-driven indexing structures (such as R-Tree) or space-driven indexing structures (such as Quadtree) to support efficient analysis and computation of data based on spatio-temporal range queries as a service basis, especially when applied to massive trajectory data. In this study, we propose a massive GPS data storage and indexing method based on uneven spatial segmentation and trajectory optimization segmentation. Primarily, the method divides GPS trajectories in a large spatio-temporal data space into multiple MBR sequences by greedy algorithm. Then, a hybrid indexing model for segmented trajectories is constructed to form a global spatio-temporal segmentation scheme, called HHBITS index, to achieve hierarchical organization of trajectory data. Eventually, a spatio-temporal range query processing method is proposed based on this index. This paper implements and evaluates the index in MongoDB and compares it with two other spatio-temporal composite indexes for performing spatio-temporal range queries efficiently. The experimental results show that the method in this paper has high performance in responding to spatio-temporal queries on large-scale trajectory data.

Abstract Background Chronic remote ischemic conditioning (CRIC) has been shown to improve myocardial ischemia in experimental animal studies; however, its effectiveness in patients with chronic stable angina (CSA) has not been investigated. We conducted a proof-of-concept study to investigate the efficacy and safety of a six-month CRIC treatment in patients with CSA. Methods The EARLY-MYO-CSA trial was a prospective, randomized, controlled trial evaluating the CRIC treatment in patients with CSA with persistent angina pectoris despite receiving ≥ 3-month guideline-recommended optimal medical therapy. The CRIC and control groups received CRIC (at 200 mmHg) or sham CRIC (at 60 mmHg) intervention for 6 months, respectively. The primary endpoint was the 6-month change of myocardial flow reserve (MFR) on single-photon emission computed tomography. The secondary endpoints were changes in rest and stress myocardial blood flow (MBF), angina severity according to the Canadian Cardiovascular Society (CCS) classification, the Seattle Angina Questionnaire (SAQ), and a 6-min walk test (6-MWT). Results Among 220 randomized CSA patients, 208 (105 in the CRIC group, and 103 in the control group) completed the treatment and endpoint assessments. The mean change in MFR was significantly greater in the CRIC group than in the control group (0.27 ± 0.38 vs. − 0.04 ± 0.25; P

PurposeThe purpose of the present study is to examine the factors contributing to the development of eating behavior in overweight and obese children from the perspective of the family system.MethodsA cross-sectional survey was conducted by using convenience sampling method to select 388 participants in two primary schools in Jiangsu, China. Individual, family and social-related factors were collected. Individual factors included age, gender, ethnicity, single child, social anxiety, depression, physical activity, sleep duration, screen time. Family factors included family environment, family structure, family function, family income, parenting style, parental feeding behavior, home food environment and marital satisfaction. Social-related factors included place of residence, number of surrounding restaurants and social support. Univariate analysis, correlation analysis and multivariate analysis were used to identify factors of eating behavior among Chinese children with overweight and obese.ResultsIn this study, 388 participants took part with a 94.865% response rate. In the univariate analysis, the significant differences regarding Dutch Eating Behavior Questionnaire (DEBQ) scores were found between children aged 6–9 years and those aged >9 years. Correlation analysis indicated that parent's nutrition literacy (r = 0.118, P

Symbiotic diazotrophs form associations with legumes and substantially fix nitrogen into soils. However, grasslands on the Qinghai-Tibet Plateau are dominated by non-legume plants, such as Kobresia tibetica. Herein, we investigated the diazotrophic abundance, composition, and community structure in the soils and roots of three plants, non-legume K. tibetica and Kobresia humilis and the legume Oxytropis ochrocephala, using molecular methods targeting nifH gene. Diazotrophs were abundantly observed in both bulk and rhizosphere soils, as well as in roots of all three plants, but their abundance varied with plant type and soil. In both bulk and rhizosphere soils, K. tibetica showed the highest diazotroph abundance, whereas K. humilis had the lowest. In roots, O. ochrocephala and K. humilis showed the highest and the lowest diazotroph abundance, respectively. The bulk and rhizosphere soils exhibited similar diazotrophic community structure in both O. ochrocephala and K. tibetica, but were substantially distinct from the roots in both plants. Interestingly, the root diazotrophic community structures in legume O. ochrocephala and non-legume K. tibetica were similar. Diazotrophs in bulk and rhizosphere soils were more diverse than those in the roots of three plants. Rhizosphere soils of K. humilis were dominated by Actinobacteria, while rhizosphere soils and roots of K. tibetica were dominated by Verrumicrobia and Proteobacteria. The O. ochrocephala root diazotrophs were dominated by Alphaproteobacteria. These findings indicate that free-living diazotrophs abundantly and diversely occur in grassland soils dominated by non-legume plants, suggesting that these diazotrophs may play important roles in fixing nitrogen into soils on the plateau.

The performance of hourglass worm gear hob is influenced by two features of the rake angle: smaller absolute value and more balanced distribution on the left and right sides of each teeth. To meet the requirements of the rake angle, a method of machining the segmental spiral flute rake faces with a cylindrical milling cutter in different drive ratios is proposed. Firstly, a mathematical model of different drive ratios machining the rake face is established based on the principle of gear meshing. The initial point is determined using the point on the spiral face at the indexing ring position of the cutter tooth machined with a fixed drive ratio. The expression for the drive ratio is then calculated based on the machine movement relationship. Next, the optimum drive ratios were determined by studying the effect of drive ratio on the value of the rake angle and the machining position of the rake face. The design results show a significant improvement compared to the values of the rake angle for the fixed drive ratio. The maximum absolute value drops from 5.3° to 0.57°, and the difference between the rake angles of the two sides on cutter tooth is reduced from 7.47° to 0.15°. This implies that the cutting conditions have been substantially improved. Finally, the machining experiment is conducted. Measurement result shows the minimum difference between the experimental and theoretical values is 0.0167° and the maximum difference is 0.5451°. Verifying the correctness of the theoretical calculation and the feasibility of practical machining.

Aiming at the problem that the basic impedance control has great impact force and is difficult to cope with environmental changes when it contacts with the tooth surface of worm gear, an adaptive impedance control method based on genetic algorithm was proposed. The influence law of spindle speed, feed speed and grinding force on the surface quality of worm gear tooth surface is analyzed. With material removal rate as the optimization objective, an optimization model of grinding process parameters is established based on particle swarm optimization algorithm, and the optimal grinding process parameters for industrial robot grinding worm gear tooth surface knife marks are obtained: Spindle speed (n=3087.82r/min), Feed speed (vf=0.51mm/s), Normal grinding force (F=19.9N). The experimental results show that the roughness of worm gear tooth surface is increased from 0.941 to 0.719 by using the optimized grinding process parameters. Moreover, this method can effectively suppress the external force influence of industrial robots in the process from free space to constrained space, and the force fluctuation is significantly reduced after contact stabilization, and it has stronger environmental adaptability and force control performance.

BackgroundRates of overweight and obesity continue to grow in adolescents. Overweight and obesity in adolescence are associated with numerous immediate and long-term adverse health conditions. Throughout adolescence, parents and the family have an important and central influence on adolescents' health and lifestyle. The home environment may be a major factor in shaping children's weight. However, our current understanding of the interplay between family-related variables in adolescents with overweight or obesity is limited and fragmented. This study aimed to assess the relationship between family-related variables in adolescents who are overweight or obese using network analysis and inform future health promotion for family-based intervention.MethodsParticipants (n = 488) were recruited from middle schools in Nanjing from October 2022 to March 2023. Participants, together with their parents, completed a questionnaire at school about the family food environment, family size, family APGAR index, family physical activity facilities, parental mental health, rearing behavior, parental weight status, drinking history, marital satisfaction, and sociodemographic characteristics.ResultsThe network split into three distinct communities of items. Network analysis showed that parental mental health and paternal rearing styles-rejection were the most central nodes in the network. In contrast, maternal weight status was the most peripheral and least connected nodes.ConclusionFamily-related variables constituted a connected network in adolescents with overweight or obesity. The pattern of network node connections supports that interventions could prioritize targeting changing parental mental health and paternal rearing styles in adolescents with overweight or obesity.

Coiled tubing (CT) technology has been widely applied in well cleanouts, drilling plug, and shale oil and gas fracturing. Fluid flow in CT produce a more significant flow friction pressure loss because of the long length and small tubing diameter coiled on the reel. Accurately prediction of flow friction pressure is a key problem of coiled tubing operation. In this paper, the flow friction behaviors in straight tubing (ST) and CT with different sizes and lengths were investigated experimentally. We analyzed experimental results and compared the test data with prediction results of published correlations. And the effects of tubing size and curvature ratio on friction factors were studied. Research findings show that the friction factor is significantly higher in CT than the corresponding ST friction factor, the maximum difference between them can be up to 30%. Furthermore, curvature ratio a remarkable effect on the friction pressure of CT. The friction factor increases as the curvature ratio increases from 0.012, 0.019, 0.031 to 0.076. For turbulent flow, a new empirical formula of friction factor in CT with roughness was proposed and validated with experimental data. The research results can support CT hydraulics design, which is the foundation and guarantee for the success of CT operation.

Whenever the drilling wellbore is at the state of gas–liquid two-phase flow, gas slips and migrates along the drilling fluid. Due to the decreased wellbore temperature and pressure during gas migration, gas volume will gradually increase. When the temperature and pressure reach the critical value of gas–liquid phase, phase change occurs. The volume of natural gas expands suddenly, and a large amount of gas is generated. It easily leads to a well blowout, which is a great challenge to well control. Therefore, analyzing the gas–liquid phase changes in drilling wellbore has important practical significance for realizing well control safety. In this paper, Lattice Boltzmann Method (LBM) is applied to simulate phase transition of wellbore gas–liquid​ two-phase system. Research results show that gas–liquid distribution after phase transition is closely related to the system original density. Compared to the critical density of gas–liquid phase change, when the system original density is lower, continuous gas forms in wellbore. While the system original density is higher, gas phase breaks out into small bubbles and migrates along the wellbore. Phase distribution directly determines gas–liquid two-phase flow pattern in wellbore, which is crucial to wellbore pressure accurate prediction. Some valuable attempts are conducted to investigate gas–liquid two-phase flow in wellbore by using LBM in this research.

Abstract Chemical doping is a powerful method to intrinsically tailor the electrochemical properties of electrode materials. Here, an interstitial boron‐doped tunnel‐type VO2(B) is constructed via a facile hydrothermal method. Various analysis techniques demonstrate that boron resides in the interstitial site of VO2(B) and such interstitial doping can boost the zinc storage kinetics and structural stability of VO2(B) cathode during cycling. Interestingly, we found that the boron doping level has a saturation limit peculiarity as proved by the quantitative analysis. Notably, the 2 at.% boron‐doped VO2(B) shows enhanced zinc ion storage performance with a high storage capacity of 281.7 mAh g−1 at 0.1 A g−1, excellent rate performance of 142.2 mAh g−1 at 20 A g−1, and long cycle stability up to 1000 cycles with the capacity retention of 133.3 mAh g−1 at 5 A g−1. Additionally, the successful preparation of the boron‐doped tunnel‐type α‐MnO2 further indicates that the interstitial boron doping approach is a general strategy, which supplies a new chance to design other types of functional electrode materials for multivalence batteries.

PurposeLaparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) and laparoscopic proximal gastrectomy with tube-like stomach reconstruction (LPG-TLR) are both function-preserving procedures performed for treating AEG. However, there is no clinical consensus on the selection of digestive tract reconstruction after proximal gastrectomy, and the best way to reconstruct the digestive tract remains controversial. This study aimed at comparing the clinical outcomes of LPG-DTR and LPG-TLR to provide some reference to the choice of AEG surgical modalities.MethodsThis was a multicenter, retrospective cohort study. we collected clinicopathological and follow-up data of patients with consecutive cases diagnosed with AEG from January 2016 to June 2021 in five medical centers. According to the way of digestive tract reconstruction after tumor resection, patients who underwent LPG-DTR or LPG-TLR were included in the present study. Propensity score matching (PSM) was performed to balance baseline variables that might affect the study outcomes. The QOL of the patients was evaluated using the Visick grade.ResultsA total of 124 eligible consecutive cases were finally included. Patients in both groups were matched using the PSM method, and 55 patients from each group were included in the analysis after PSM. There was no statistically significant difference between the two groups in terms of the operation time, amount of intraoperative blood loss, days of postoperative abdominal drainage tube placement, postoperative hospitalization days, total hospitalization cost, the total number of lymph nodes cleared, and the number of positive lymph nodes (P>0.05). There was a statistically significant difference between the two groups in terms of time to first flatus after surgery and postoperative soft food recovery time (P0.05).ConclusionThe anti-reflux effect and quality of life of LPG-DTR for AEG were comparable to those of LPG-TLR. Compared with LPG-TLR, LPG-DTR provide better nutrition status for patients with AEG. LPG-DTR is a superior reconstruction method after proximal gastrectomy.

The prediction of the water film depth (WFD) on the road surface can help with road skid resistance research and reduce the risk associated with driving on rainy days. At present, there are many empirical and analytical models based on drainage length, slope, rainfall intensity and other parameters. Considering the influence of road surface runoff and starting from the Reynolds number formula of road surface water flow, a new road surface WFD calculation formula that considers the movement state of laminar water flow is derived. The results show that the changing trends of various parameters in the prediction model (drainage length, rainfall intensity, road slope) affecting WFD are consistent with those of the existing model. It is also found that the initial water film depth, initial speed of rainwater, and rainfall angle have little impact on WFD. The predicted value of the model has a suitable matching degree compared with the classical empirical model, which provides a new approach to the prediction of road water film depth.

China holds large-scale lead–zinc mineral resources; however, mining activities often cause severe contamination by heavy metals. This study systemically assessed contamination by eight heavy metals (Cu, Zn, Cd, Pb, Cr, Hg, Ni, and As) in mine tailings, soil, and groundwater from 27 contaminated sites across China. Regarding mine tailings, 1% of the mine tailing samples were hazardous waste and 20% were class II non-hazardous waste. Regarding soil, Zn and Pb showed the highest mean concentrations, at 5574.67 mg/kg and 2034.88 mg/kg, respectively. The indexes of geo-accumulation (Igeo) of eight heavy metals ranged from −3.62 to 7.67, while Zn, Pb, and Cd showed the highest environmental risk levels as the priority pollutants. The contamination levels of these heavy metals in groundwater were generally in the order of Zn>As>Pb>Ni>Cd>Cu>Hg>Cr. In this study, 20% of the soil and 10% of the groundwater samples exceeded the corresponding quality limits. The content of heavy metals in soil, groundwater, and mine tailing were positively correlated, demonstrating the main pollution source and transport paths. The pollution levels of heavy metals in soil and groundwater were listed in the foremost and moderate positions compared with similar sites from other countries, respectively. These results may help determine the pollution levels of lead–zinc mining regions and direct the remediation activities of target sites to support the environmental management of abandoned mining and tailing waste in China.

Some photosensitive resins have poor mechanical properties after 3D printing. To overcome these limitations, a polyurethane acrylate oligomer (PUA) microsphere was prepared using the Pickering emulsion template method and ultraviolet (UV) curing technology in this paper. The prepared PUA microspheres were added to PUA-1,6-hexanediol diacrylate (HDDA) photosensitive resin system for digital light processing (DLP) 3D printing technology. The preparation process of PUA microspheres was discussed based on micromorphology, and it was found that the oil-water ratio of the Pickering emulsion and the emulsification speed had a certain effect on the microsphere size. As the oil-water ratio and the emulsification speed increased, the microsphere particle size decreased to a certain extent. Adding a suitable proportion of PUA microspheres to the photosensitive resin can improve the mechanical properties and thermal stability. When the modified photosensitive resin microsphere content was 0.5%, the tensile strength, elongation at break, bending strength, and initial thermal decomposition temperature were increased by 79.14%, 47.26%, 26.69%, and 10.65%, respectively, compared with the unmodified photosensitive resin. This study provides a new way to improve the mechanical properties of photosensitive resin 3D printing. The resin materials studied in this work have potential application value in the fields of ceramic 3D printing and dental temporary replacement materials.

Motor faults not only damage the motor body but also affect the entire production system. When the motor runs in a steady state, the characteristic frequency of the fault current is close to the fundamental frequency, so it is difficult to effectively extract the fault current components, such as the broken rotor bar. In this paper, according to the characteristics of electromagnetic force and vibration, when the rotor eccentricity and the broken bar occur, the vibration signal is used to analyze and diagnose the fault. Firstly, the frequency, order, and amplitude characteristics of electromagnetic force under rotor eccentricity and broken bar fault are analyzed. Then, the fault vibration acceleration value collected by a one-dimensional dilated convolution pair is extracted, and the SeLU activation function and residual connection are introduced to solve the problem of gradient disappearance and network degradation, and the fault motor model is established by combining average ensemble learning and SoftMax multi-classifier. Finally, experiments of normal rotor eccentricity and broken bar faults are carried out on 4-pole asynchronous motors. The experimental results show that the accuracy of the proposed method for motor fault detection can reach 99%, which meets the requirements of fault motor detection and is helpful for further application.

The drainage of asphalt pavement requires the use of a large amount of high-viscosity-modified asphalt, which faces the service environment under dynamic water erosion. The feasibility of recycling high-viscosity-modified asphalt should be investigated to facilitate sustainable infrastructure construction. This study used ultrasonic equipment to simulate dynamic water erosion test conditions and tested the adhesion performance of different types of recycled high-viscosity asphalt at various environmental temperatures. The adhesion energy index and microstructure of recycled high-viscosity asphalt were analyzed using the contact angle test and AFM test. The results demonstrate that the higher the environmental temperature, the worse the anti-stripping performance of recycled high-viscosity asphalt. From the perspective of adhesion performance indicators, a 6% recycling agent dosage is more conducive to restoring the performance of aged high-viscosity -modified asphalt. The AFM test showed that the microstructure of high-viscosity -modified asphalt represented significant changes with an increase in the recycling agent content, and the change in the adhesion force of recycled high-viscosity -modified asphalt was consistent with the results of macroscopic adhesion performance tests. This study illustrates the applicability of implementing regeneration technology for the recycling of aged drainage asphalt pavement.

Road is one of important traffic lifelines that could be damaged after disaster by landslide rubble, buildings debris, and collapsed branches of trees. Therefore, road damage detection and assessment using post-Disaster High-Resolution Remote Sensing Images is extremely important for finding optimal paths and conducting rescue missions. In an emergency context, the existing methods based on change detection for road damage detection are difficult to achieve due to the mismatch of different data sources, especially for rural areas where the pre-disaster remote sensing imagery are hard to obtain. In this paper, a novel method based on the Tracking, Learning, and Detector (TLD) framework for detecting the damaged road region from post-disaster high-resolution remote sensing image is presented. First, a spoke wheel operator is employed to define the initial template of road. Then, the TLD framework is used to identify the suspected road damaged areas. Finally, the damaged road areas are extracted by pruning the false damaged roads. The proposed method was evaluated using post-disaster high-resolution remote sensing images collected over Beichuan, China in 2008 and Lushan, China in 2013. The results show that the proposed method is feasible and effective for road damage detection and assessment. Our main conclusion is that such an approach qualifies for practical use.

Background. This study explored the efficacy of the “L-sandwich” strategy, which involves the implantation of stents in the main vessel (MV) and shaft of the side branch (SB) with a drug-coated balloon (DCB) applied to the SB ostium, for coronary true bifurcation lesions. Methods and Results. Of 99 patients with true bifurcation lesions, 38 patients underwent the “L-sandwich” strategy (group A), 32 patients underwent a two-stent strategy (group B), and 29 patients underwent a single-stent + DCB strategy (group C). Angiography outcomes (late lumen loss [LLL], minimum lumen diameter [MLD]), and clinical outcomes (major adverse cardiac events [MACEs]) were analyzed. At 6 months, the MLD of the SB ostium in groups A and B were similar (P>0.05) and group A larger than group C (P0.05), and patients in the other groups had no MACEs. Conclusions. The “L-sandwich” strategy was feasible for the treatment of true coronary bifurcation lesions. It is a simpler procedure with similar acute lumen gain than the two-stent strategy, results in a larger SB lumen than the single-stent + DCB strategy, and it can also be used as a remedy for dissection following the single-stent + DCB strategy.

As more and more distributed photovoltaics (PVs) are installed in distribution networks, the dynamic characteristics of PVs affect the operation of the bulk power system. Accurate simulation of PV characteristics is essential for the needs of power system transient security and stability analysis. However, because of the large number of distributed PVs, detailed modeling of each PV significantly increases the electromechanical transient simulation time. The equivalent study of distribution networks with distributed PVs is needed to improve simulation efficiency. However, existing equivalent methods of PVs mainly focus on centralized PVs but are unsuitable for distributed PVs with significantly different dynamic characteristics. To improve simulation efficiency, this paper proposes an equivalent method of the distribution network with distributed PVs for electromechanical transient study based on user-defined (UD) modeling. Firstly, the equivalent structure of the distribution network is established. The static equivalent of the transmission lines and the dynamic equivalent model of loads are carried out. Then, a UD model based on PSASP is established for the dynamic equivalent of the distributed PVs. Compared with the current PV models in simulation software, the UD model has multiple sets of parameters for the equivalent of distributed PVs with different dynamic characteristics. Finally, the particle swarm optimization (PSO) algorithm is used to obtain the parameters of the equivalent PV. The effectiveness of the proposed method is verified under an example of a distribution network with PVs in PSASP.

With the grid connection of a large number of distributed photovoltaics (PVs), the structure and operation mode of the distribution network are changed. Detailed modeling of the distribution network can accurately analyze the impact of these changes on the power system but leads to high model complexity and large amounts of calculation. Equivalent of the distribution network effectively reduces the model scale, where the static equivalent is the basis for the other equivalents. Most of the existing static equivalent methods target a few typical operation modes. However, they are unsuitable for multiple variable scenarios caused by PV power fluctuation. This paper proposes a static equivalent method of the distribution network with distributed PVs to adapt to complex and changeable operation modes. Firstly, a scenario generation method of PV and load power based on kernel density estimation and a copula function is proposed considering fluctuation and correlation of PV and load. Secondly, a parameter optimization method based on particle swarm optimization (PSO) is proposed to optimize the parameters in the static equivalent model of the distribution network under a single operation mode. Thirdly, an equivalent parameter estimation model based on convolutional neural network (CNN) is proposed to improve the efficiency of model parameter calculation under multiple operation modes. The effectiveness of the proposed method is verified under an example of an actual distribution network in Shandong, China. This method has efficiency and is suitable for multiple operating modes.

AbstractThe Upper Urho Formation on the northwest margin of the Junggar Basin is a key formation for oil and gas exploration. Based on the core observation, combined with the analysis of cast thin section, scanning electron microscope, energy dispersive spectrum, X-ray diffraction, fluid inclusion, and porosity-permeability test, the petrological characteristics, physical properties, diagenesis types, and their effects on the physical properties of the glutenite reservoir of Upper Urho Formation were studied systematically. The results show that the lithology of reservoir of the Upper Urho Formation in Zhongguai Salient is mainly conglomerate with a small amount of sandstone. The permeability of conglomerate is generally higher than that of sandstone, and the physical properties of granule conglomerate and fine pebble conglomerate are relatively better. The reservoir experienced complicated diagenesis, mainly including compaction, cementation, and dissolution, also including filler shrink seam and metasomatism. At present, the reservoir of Upper Urho Formation in Zhongguai Salient is mainly at the middle diagenetic stage A period and partly at the middle diagenetic stage B period. The original porosity lost by compaction is the largest, which is the fundamental reason for low porosity and low permeability of reservoir. The influence of cementation on reservoir physical properties has two sides. On the one hand, the development of cementation is the main reason for low porosity and low permeability of reservoir. On the other hand, the early cementation resists compaction to a certain extent and provides a material basis for the later dissolution. The reservoir of Upper Urho Formation in Zhongguai Salient is deeply buried and has experienced strong compaction and cementation, and the reservoir properties are poor, but the secondary pore space formed by dissolution improves the reservoir properties to some extent. The study concluded that the dense glutenite reservoirs of the Upper Urho Formation can develop relatively high-quality reservoirs on a local scale, which is of guiding significance for the exploration of the Upper Urho Formation.

Although drug-loaded polymethyl methacrylate (PMMA) bone cement had been widely used in the vertebroplasty and arthroplasty, the mismatch between the drug release cycle and clinical demand, as well as low drug release rate and single therapeutic effect restricted the use of PMMA bone cement as the drug carrier in clinical applications. In this study, poly(methyl methacrylate-acrylic acid)-alendronate [P(MMA-AA)-ALN] drug-loaded nanoparticles with anti-osteoporosis function were synthesized and introduced into the gentamicin sulfate (GS) loaded PMMA bone cement. The rapidly expandable bone cement with water absorption pathways was constructed by adjusting the particle size of P(MMA-AA)-ALN nanoparticles. More importantly, the sustained release of GS and ALN were creatively achieved by their migration through the water absorption pathways composed of P(MMA-AA)-ALN nanoparticles. The results showed that the cumulative release ratios of GS and ALN in the composites were up to 74.67 ± 1.02 % and 75.23 ± 1.96 %. Meanwhile, the release cycles of GS and ALN were extended to 4 weeks and 15 weeks, effectively preventing infection, and matching the normal bone healing cycle. In addition, the swelling and dual drug release bone cement (SDBC) displayed superior antibacterial activity and biocompatibility.

African swine fever (ASF) is a severe and highly contagious viral disease that affects domestic pigs and wild boars, characterized by a high fever and internal bleeding. The disease is caused by African swine fever virus (ASFV), which is prevalent worldwide and has led to significant economic losses in the global pig industry. In this study, three pairs of specific primers and TaqMan probes were designed for the ASFV B646L, MGF505-2R and I177L genes. After optimizing the reaction conditions of the annealing temperature, primer concentration and probe concentration, triplex crystal digital PCR (cdPCR) and triplex real-time quantitative PCR (qPCR) were developed for the detection and differentiation of the wild-type ASFV strain and the MGF505-2R and/or I177L gene-deleted ASFV strains. The results indicate that both triplex cdPCR and triplex qPCR were highly specific, sensitive and repeatable. The assays could detect only the B646L, MGF505-2R and I177L genes, without cross-reaction with other swine viruses (i.e., PRRSV, CSFV, PCV2, PCV3, PEDV, PDCoV and PRV). The limit of detection (LOD) of triplex cdPCR was 12 copies/reaction, and the LOD of triplex qPCR was 500 copies/reaction. The intra-assay and inter-assay coefficients of variation (CVs) for repeatability and reproducibility were less than 2.7% for triplex cdPCR and less than 1.8% for triplex qPCR. A total of 1510 clinical tissue samples were tested with both methods, and the positivity rates of ASFV were 14.17% (214/1510) with triplex cdPCR and 12.98% (196/1510) with triplex qPCR, with a coincidence rate of 98.81% between the two methods. The positivity rate for the MGF505-2R gene-deleted ASFV strains was 0.33% (5/1510), and no I177L gene-deleted ASFV strain was found. The results indicate that triplex cdPCR and triplex qPCR developed in this study can provide rapid, sensitive and accurate methods for the detection and differentiation of the ASFV B646L, MGF505-2R and I177L genes.

Abstract The problem of joint synthesis of spatial power pattern and mainlobe radiation polarisation using a vector antenna array is considered in the presence of array manifold errors. A general approach to the synthesis problem is to formulate the restriction on the power and radiation polarisation as a convex optimisation programing. However, for certain types of vector antennas like tripole and electromagnetic vector sensors, the optimal weights might be extremely large and the resultant beampattern could be very sensitive to the array manifold errors. An intuitive explanation on this phenomenon is given based on the subspace theory. A worst case performance optimisation technique‐ based scheme is presented to draw attention to the polarised beampattern synthesis against the large weights problem and array manifold errors. Numerical examples regarding different types of vector antennas used for one‐ and two‐dimensional polarised beampattern synthesis are provided to validate the efficacy of the scheme.

Lymphatic endothelial cell homeostasis plays important roles in normal physiological cardiac functions, and its dysfunction significantly influences pathological cardiac remodeling after myocardial infarction (MI). Our results revealed that sphingosine 1-phosphate receptor 1 (S1pr1) expression in cardiac lymphatic endothelial cells (LECs) was sharply changed after MI. It has been shown that S1pr1 tightly controlled LEC functions and homeostasis. We thus hypothesized that lymphatic endothelial S1pr1 might be involved in post-MI cardiac remodeling. We generated LEC-conditional S1pr1 transgenic mice, in which S1pr1 expression was reduced in cardiac LECs. We performed the left anterior descending coronary artery (LAD) ligation operation to induce MI in these mice. Cardiac functions and remodeling were examined by echocardiography analysis and serial histological analysis. Meanwhile, we performed adoptive cell transfer experiments to monitor macrophage trafficking in post-MI myocardium and their draining lymphatic system. Furthermore, in vitro cell culture experiments and mechanism studies were undertaken to uncover the molecular mechanism by which LEC-S1pr1 regulated cardiac inflammation and remodeling after MI. Our results showed that S1pr1 expression significantly decreased in cardiac LECs after MI. Our in vivo experiments showed that the reduced expression of LEC-S1pr1 deteriorated cardiac function and worsened pathological cardiac remodeling after MI. Our further results demonstrated that the reduced expression of LEC-S1pr1 did not influence macrophage infiltration in an early inflammatory phase of MI, but significantly affected macrophages clearance in the later phase of MI via afferent cardiac lymphatics, and thus influenced inflammatory responses and cardiac outcome after MI. Further study showed that S1P/S1pr1 activated ERK signaling pathway and enhanced CCL2 expression, which promoted macrophage trafficking in a paracrine manner. This study reveals that cardiac lymphatic endothelial cells tightly control macrophage trafficking via lymphatic vessels in injured hearts via S1P/S1pr1/ERK/CCL2 pathway and thus regulate post-MI immune modulation and heart repair. This study highlights the importance of cardiac lymphatic vessel system in orchestrating post-MI immune responses and cardiac remodeling by regulating macrophage transit in injured hearts. Our finding implies that a feasible modulation of S1pr1 signaling in LECs might provide a promising target to resolve excessive inflammation and to ameliorate adverse cardiac remodeling after MI.

The effect of proportion on the physicochemical and osteogenic properties of electrospun nano-hydroxyapatite/polylactic acid (nHAP/PLA) fiber membrane was investigated from 0/100 to 20/80 (nHAP/PLA mass ratio), aiming to optimise the proportion and integrate mechanical support, biodegradability, cell infiltration and osteogenic activity for better bone repair. The results showed the incorporated nHAP increased the hydrophilicity of the fiber surface, and 6–10 wt% nHAP/PLA membrane showed the enhanced modulus in the direction perpendicular to membrane plane. Biological experiments demonstrated the nHAP proportion-dependent osteogenic activity of nHAP/PLA membranes. The addition of 6–10 wt% nHAP in the fiber membrane significantly promoted cell proliferation and differentiation. In vivo experiments of stacked implantation of the membrane displayed multilayer growth in the pure PLA group owing to the hydrophobicity of PLA and single-layer growth in the nHAP/PLA group because the hydrophilicity of the nHAP/PLA membrane improved the adhesion of the layers. The addition of 6–10 wt% nHAP/PLA also promoted cell recruitment and infiltration and increased osteogenesis, with enhancements of 41% in bone tissue volume/total tissue volume and 37% in bone mineral density. Our study provides helpful support for the preparation of composite electrospun membranes with improved osteogenic activity by optimising the organic–inorganic proportion.

IntroductionPhase angle (PhA) is a ratio of reactance and resistance {arctangent (reactance (Xc)/resistance (R)) × (180°/π)}, which can be obtained by bioelectrical impedance analysis (BIA). PhA indicates cellular health and integrity, and it is also considered as a prognostic tool in medical disorders and an indicator of nutritional status (especially of muscle quality) in patients with obesity. However, PhA has limited usefulness in clinical practice because of a lackness of reference values for Chinese overweight and obese populations. The main aim of this study was to show PhA reference data in different age and BMI groups by sex. In addition, we also study the association of age, sex, and BMI on PhA.MethodsA total of 1729 overweight and obese participants were included in this study. PhA and body composition were measured using segmental multifrequency BIA. Differences in mean values for variables were tested by one-way analysis of variance. Multiple regression analysis was used to assess the associations of PhA with age, sex and BMI.ResultsMultiple regression analysis showed that age, sex and BMI were significant (P < 0.05) independent influence factors of PhA in Chinese overweight and obese adults when age and BMI were continues variables. The mean PhA value for all participants was 5.5°. Mean BMI, age, weight, height and 50kHz-PhA were significantly higher (P < 0.001) in male participants than female ones. In age groups and BMI groups, mean 50kHz-PhA was significantly higher (P < 0.005) in male participants than female ones. When age groups and BMI groups were categorical variables, multiple regression analysis showed that different age groups (46–55 years and ≥ 56 years) had a significantly lower (P < 0.005) PhA as compared with the baseline group (18-25 years) and different BMI groups (≥ 28 kg/m2) had a significantly higher (P < 0.05) PhA as compared with the baseline group (24–27.9 kg/m2).ConclusionPhA differed according to age, sex and BMI. Reference data in this study can be taken into consideration when deriving the reference values for overweight and obese Chinese populations.

Miniaturized laser-initiated pyrotechnic devices have great application prospects in aerospace and modern weapon systems due to their excellent energy output performance and reliability. In order to develop a low-energy insensitive laser detonation technology based on a two-stage charge structure, it is important to deeply analyze the motion law of a titanium flyer plate driven by the deflagration of the first-stage charge (RDX). The effects of the charge mass of RDX, flyer plate mass, and barrel length on the motion law of flyer plates were studied through a numerical simulation method based on the Powder Burn deflagration model. The consistency between the numerical simulation and the experimental results was analyzed using the paired t confidence interval estimation method. The results show that the Powder Burn deflagration model can effectively describe the motion process of the RDX deflagration-driven flyer plate with a 90% confidence level, and its velocity error is ≤6.7%. The speed of the flyer plate is proportional to the mass of the RDX charge, inversely proportional to the mass of the flyer plate, and exponentially related to its moving distance. As the moving distance of the flyer plate increases, the RDX deflagration products and air in front of the flyer plate are compressed, which inhibits the motion of the flyer plate. In the optimum state (the mass of the RDX charge is 60 mg, the mass of the flyer is 85 mg, and the length of the barrel is 3 mm), the speed of the titanium flyer reaches 583 m/s, and the peak pressure of the RDX deflagration reaches 2182 MPa. This work will provide a theoretical basis for the refined design of a new generation of miniaturized high-performance laser-initiated pyrotechnic devices.

Amphenicol antibiotics including chloramphenicol (CAP), florfenicol (FF) and thiamphenicol (TAP) have been widely used in aquaculture and veterinary to treat various infections. Because of their high toxicity, it is important to detect these amphenicol antibiotics simultaneously. Using the monoclonal antibody against CAP (mAbCAP) binding CAP only and the mAbFF recognizing both FF and TAP, the two antibodies were covalently coupled to CNBr-activated Sepharose-4B for the simultaneous extraction of CAP, FF and TAP from samples. The bound CAP, FF and TAP were eluted from the Sepharose-4B and measured by LC–MS/MS. The extraction conditions of the two-antibodies-immobilized immunoaffinity clean-up (IAC) for CAP, FF and TAP were optimized and the maximum capacity was investigated. The extraction efficiency of IAC for CAP, FF and TAP was 1.1–2.1 times higher than that of SPE. The LC–MS/MS coupled with IAC was a powerful analytical method for the detection of CAP, FF and TAP simultaneously.

Abstract In underground mining operations, the overlying strata move, deform, and crack as the underground working face advances due to strata breakage, failure, and subsidence, forming a “vertical three zone” over the mined out area. The permeability of strata under mining changes differently in different zones. Therefore, studying the distribution of strata permeability is very important to obtain knowledge of gas migration pattern in the overlying strata in order to increase the gas extraction efficiency. In this study, a series of numerical models are developed to describe the overlying strata movement for three different zones. In detail, models for calculating the strata subsidence for fracture and bending zones and analyzing strata collapsing development for the caving zone are proposed based on the influence function method and mechanical analyses. In addition, on the basis of such models, a new comprehensive model to describe the strain‐porosity‐permeability of strata is developed. In the case study of applying such models in an underground mine, the reliability of the strata movement model is verified and the permeability change is also calculated, which gives a good guidance to design the location of gas drainage roadway practices in the future. The field engineering practice shows its good application.

Abstract Background At present, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with disastrous consequences for people of all countries. The traditional Chinese medicine prescription Dayuanyin (DYY), a classic prescription for the treatment of plague, has shown significant effects in the treatment of COVID-19. However, its specific mechanism of action has not yet been clarified. This study aims to explore the mechanism of action of DYY in the treatment of COVID-19 with the hope of providing a theoretical basis for its clinical application. Methods First, the TCMSP database was searched to screen the active ingredients and corresponding target genes of the DYY prescription and to further identify the core compounds in the active ingredient. Simultaneously, the Genecards database was searched to identify targets related to COVID-19. Then, the STRING database was applied to analyse protein–protein interaction, and Cytoscape software was used to draw a network diagram. The R language and DAVID database were used to analyse GO biological processes and KEGG pathway enrichment. Second, AutoDock Vina and other software were used for molecular docking of core targets and core compounds. Finally, before and after application of DYY, the core target gene IL6 of COVID-19 patients was detected by ELISA to validate the clinical effects. Results First, 174 compounds, 7053 target genes of DYY and 251 genes related to COVID-19 were selected, among which there were 45 target genes of DYY associated with treatment of COVID-19. This study demonstrated that the use of DYY in the treatment of COVID-19 involved a variety of biological processes, and DYY acted on key targets such as IL6, ILIB, and CCL2 through signaling pathways such as the IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and cytokine–cytokine receptor interaction. DYY might play a vital role in treating COVID-19 by suppressing the inflammatory storm and regulating immune function. Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). Finally, clinical studies showed that the level of IL6 was elevated in COVID-19 patients, and DYY can reduce its levels. Conclusions DYY may treat COVID-19 through multiple targets, multiple channels, and multiple pathways and is worthy of clinical application and promotion.