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Background and purpose: Long non-coding RNA (lncRNA) LINC01410, with a length of 647 bp, participates in a variety of tumor biological processes. However, the role and mechanism of LINC01410 involved in esophageal squamous cell carcinoma (ESCC) remain unclear. This study aimed to explore the potential mechanism of LINC01410 promoting ESCC proliferation and invasion, to provide a potential prognostic indicator and therapeutic target for individuals with ESCC. Methods: Gene Expression Profiling Interactive Analysis 2 (GEPIA2) databases were used to analyze the expression of LINC01410 and overall survival in esophageal squamous cell carcinoma data set in the Cancer Genome Atlas (TCGA). Gene Set Enrichment Analysis (GSEA) was performed to identify the underlying signaling pathways involved in the biological effects of LINC01410 in ESCC. A total of 62 pairs of ESCC tissues and paracancerous tissues from ESCC patients who underwent radical surgery in the Department of Thoracic Surgery at the First Affiliated Hospital of Xinxiang Medical College and the First People's Hospital of Pingdingshan City from January 2020 to December 2021 were collected. This project has been approved by the Hospital Ethics Committee (First Affiliated Hospital of Xinxiang Medical College, No. 2018036; First People's Hospital of Pingdingshan City, No. 2019-018). The expression of LINC01410 in ESCC tissues was detected by real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR). We transfected EC109 cells with LV-NC or LV-over/LINC01410 and EC9706 cells with shRNA-NC or shRNA-LINC01410. Stable transfected cells (EC109/NC, EC109/OE, EC9706/NC and EC9706/KD) were selected in primary cell culture medium containing puromycin. The expression of LINC01410 was detected by RTFQ-PCR. The impact of LINC01410 on ESCC cell proliferation was determined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. The effect of LINC01410 on ESCC cell invasion was detected by transwell migration assay. T cell factor/lymphoid enhancer factor 1 (TCF/LEF1) luciferase reporter assay was performed to validate the effect of LINC01410 on the activity of canonical Wnt/β-catenin signaling pathway. The expressions of Wnt/β-catenin and epithelial-mesenchymal transition (EMT) signal pathway related proteins in ESCC cells were detected by Western blot. Results: By analyzing the LINC01410 expression from ESCC samples in TCGA by GEPIA2, we found LINC01410 was consistently increased in ESCC tumors compared with normal tissues (P

Here, flower‐like manganese oxide with enriched oxygen vacancies were reported for high performance supercapacitors. The moderate oxygen‐vacancy were achieved by controlling annealing atmosphere. Benefiting from improving the conductivity and the density of active sites, MnOx−Ar sample as an electrode material has remarkable specific capacity (339 mAh g−1 at 0.5 A g−1), extraordinary rate capability (90 % capacity retention at 1 A g−1), and good cycling property (90 % capacity retention at 1 A g−1 after 5000 cycles). Additionally, the asymmetric supercapacitor (ASC) was assembled which used the MnOx−Ar sample as cathode and Kochen Black (KB) as anode, which displayed a remarkable energy density (16 Wh kg−1) at a large power density (7593 W kg−1). These results, on the one hand, further expand the application of MnO2‐based materials, and on the other hand, offer a new perspective for the oxygen non‐stoichiometry in material electrochemistry. [ABSTRACT FROM AUTHOR]

Detrimental rock‐salt and/or spinel surface phases parasitic to Ni‐rich layered oxides with high theoretical capacity are quite formidable which are reported to be eliminated only through alien element dopings and/or surface modifications. Herein, these surface phases are directly eliminated successfully during the synthesis of pristine LiNi0.8Co0.2O2 and LiNi0.9Co0.1O2 using an expanded graphites (EGs) template approach, accompanied by the formation of unique 3D porous structures. The elimination of surface phases may be ascribed to the 3D porous structures formed during the calcination processes at both low and high temperatures, which enables the access of sufficient oxygen to individual nanoparticles and thus promotes the oxidization of Ni2+ to Ni3+ to reduce Li/Ni disordering. Both LiNi0.8Co0.2O2 and LiNi0.9Co0.1O2 show excellent rate capability, long‐term cycling stability, and high initial Coulombic efficiencies (ICEs), such as 210.4 (149) and 222.6 (133) mAh g−1, ICEs of 94.9% and 93.8% at 0.1 C (20 C), and capacity retentions of 74% after 500 cycles at 1 C and 76% after 300 cycles at 1 C, respectively, far better than those synthesized using a conventional sol–gel recipe. This study provides a simple and novel platform for directly synthesizing detrimental surface phases free and chemically stoichiometric Ni‐rich layered oxides with high performance. [ABSTRACT FROM AUTHOR]