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8. The anti-amoebic activity of Pinus densiflora leaf extract against the brain-eating amoeba Naegleria fowleri.

Author

Lê, Hương Giang, Kim, Woong, Kang, Jung-Mi, Võ, Tuấn Cường, Yoo, Won Gi, Cheong, Hyeonsook, and Na, Byoung-Kuk

Subjects
JAPANESE red pine, PLANT extracts, NAEGLERIA fowleri, GENE ontology, DRUG efficacy
Abstract

Naegleria fowleri invades the brain and causes a fatal primary amoebic meningoencephalitis (PAM). Despite its high mortality rate of approximately 97%, an effective therapeutic drug for PAM has not been developed. Approaches with miltefosine, amphotericin B, and other antimicrobials have been clinically attempted to treat PAM, but their therapeutic efficacy remains unclear. The development of an effective and safe therapeutic drug for PAM is urgently needed. In this study, we investigated the anti-amoebic activity of Pinus densiflora leaf extract (PLE) against N. fowleri. PLE induced significant morphological changes in N. fowleri trophozoites, resulting in the death of the amoeba. The IC50 of PLE on N. fowleri was 62.3±0.95 µg/ml. Alternatively, PLE did not significantly affect the viability of the rat glial cell line C6. Transcriptome analysis revealed differentially expressed genes (DEGs) between PLE-treated and non-treated amoebae. A total of 5,846 DEGs were identified, of which 2,189 were upregulated, and 3,657 were downregulated in the PLE-treated amoebae. The DEGs were categorized into biological process (1,742 genes), cellular component (1,237 genes), and molecular function (846 genes) based on the gene ontology analysis, indicating that PLE may have dramatically altered the biological and cellular functions of the amoeba and contributed to their death. These results suggest that PLE has anti-N. fowleri activity and may be considered as a potential candidate for the development of therapeutic drugs for PAM. It may also be used as a supplement compound to enhance the therapeutic efficacy of drugs currently used to treat PAM. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Phragmites australis (Cav.) Trin. ex Steud. Extract Induces Apoptosis-like Programmed Cell Death in Acanthamoeba castellanii Trophozoites

Author

Lê, Hương-Giang, primary, Choi, Ji-Su, additional, Hwang, Buyng-Su, additional, Jeong, Yong-Tae, additional, Kang, Jung-Mi, additional, Võ, Tuấn-Cường, additional, Cho, Pyo-Yun, additional, Lee, Young-Kyung, additional, Yoo, Won-Gi, additional, Hong, Yeonchul, additional, Oh, Young-Taek, additional, and Na, Byoung-Kuk, additional

Published
2022
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19. Molecular Profiles of Multiple Antimalarial Drug Resistance Markers in Plasmodium falciparum and Plasmodium vivax in the Mandalay Region, Myanmar

Author

Lê, Hương Giang, primary, Naw, Haung, additional, Kang, Jung-Mi, additional, Võ, Tuấn Cường, additional, Myint, Moe Kyaw, additional, Htun, Zaw Than, additional, Lee, Jinyoung, additional, Yoo, Won Gi, additional, Kim, Tong-Soo, additional, Shin, Ho-Joon, additional, and Na, Byoung-Kuk, additional

Published
2022
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27. Additional file 2 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan

Author

Ullah, Ibrar, Afridi, Sahib Gul, Israr, Muhammad, Khan, Hizbullah, Shams, Sulaiman, Zaib, Komal, Le, Huong Giang, Kang, Jung-Mi, Na, Byoung-Kuk, and Khan, Asifullah

Abstract

Additional file 2: Table S1. The haplotypes identified in pvama-1 DI region of KP, Pakistan P. vivax isolates.

Published
2022
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28. Additional file 4 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan

Author

Ullah, Ibrar, Afridi, Sahib Gul, Israr, Muhammad, Khan, Hizbullah, Shams, Sulaiman, Zaib, Komal, Le, Huong Giang, Kang, Jung-Mi, Na, Byoung-Kuk, and Khan, Asifullah

Abstract

Additional file 4: Fig S3. Pearson correlation plot of KP and global pvama-1 samples based on pairwise Fst values. The plot shows clustering and correlation between the groups in hierarchical order. The dark brackets and large sizes depict the minimum genetic distinction and high correlation.

Published
2022
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29. Additional file 3 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan

Author

Ullah, Ibrar, Afridi, Sahib Gul, Israr, Muhammad, Khan, Hizbullah, Shams, Sulaiman, Zaib, Komal, Le, Huong Giang, Kang, Jung-Mi, Na, Byoung-Kuk, and Khan, Asifullah

Abstract

Additional file 3: Fig S2. Linkage disequilibrium (LD) pattern of pvama-1 DI sequences of P. vivax isolates from KP, Pakistan. The LD index (R2) (Y-axis) plotted against nucleotide distance (X-axis) using a two tailed Fisher’s exact test.

Published
2022
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30. Additional file 1 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan

Author

Ullah, Ibrar, Afridi, Sahib Gul, Israr, Muhammad, Khan, Hizbullah, Shams, Sulaiman, Zaib, Komal, Le, Huong Giang, Kang, Jung-Mi, Na, Byoung-Kuk, and Khan, Asifullah

Abstract

Additional file 1: Fig S1. Frequency of different haplotypes detected in pvama-1 DI of P. vivax samples collected from different districts of KP, Pakistan

Published
2022
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47. Overall Prevalence and Distribution of Knockdown Resistance (kdr) Mutations in Aedes aegypti from Mandalay Region, Myanmar

Author

Naw, Haung, primary, Su, Mya Nilar Chaw, additional, Võ, Tuấn Cường, additional, Lê, Hương Giang, additional, Kang, Jung-Mi, additional, Jun, Hojong, additional, Mya, Yi Yi, additional, Myint, Moe Kyaw, additional, Lee, Jinyoung, additional, Sohn, Woon-Mok, additional, Kim, Tong-Soo, additional, and Na, Byoung-Kuk, additional

Published
2020
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48. Additional file 1 of Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax

Author

Tuấn Cường Võ, Hương Giang Lê, Kang, Jung-Mi, Moe, Mya, Haung Naw, Myint, Moe Kyaw, Jinyoung Lee, Woon-Mok Sohn, Tong-Soo Kim, and Byoung-Kuk Na

Abstract

Additional file 1: Figure S1. Schematic structure of pvcsp. The gene is separated into three regions; an N-terminal non-repeat region, a central repeat region (CRR), and a C-terminal non-repeat region. The CRR consists of two major repeat peptide motifs (PRMs), termed VK210 and VK247.

Published
2020
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49. Additional file 5 of Genetic diversity of Plasmodium vivax and Plasmodium falciparum lactate dehydrogenases in Myanmar isolates

Author

Jinyoung Lee, Kim, Tae, Hương Lê, Yoo, Won, Kang, Jung-Mi, Seong-Kyu Ahn, Myint, Moe, Khin Lin, Tong-Soo Kim, and Byoung-Kuk Na

Abstract

Additional file 5: Fig. S2. Structural comparison between PvLDH and PfLDH. (a) Semi-transparent cartoon representations of PvLDH in cyan and PfLDH in orange reveal a similar overall fold with 0.06 RMSD. All functional residues are identical to the amino acids in the corresponding positions; catalytic residues (R95, D155, R158 and H182) in red spheres, the active site (K84) and cofactor-binding site (P235 and P239) in blue spheres, and the substrate-specific loop (D90–N94) in green spheres. (b) Perpendicular view of (a) shows a Rossmann fold-like subdomain, which is composed of 6 β-strands and 5 α-helices.

Published
2020
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