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4. Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin

Author

Ruf, Benjamin, Bruhns, Matthias, Babaei, Sepideh, Kedei, Noemi, Ma, Lichun, Revsine, Mahler, Benmebarek, Mohamed-Reda, Ma, Chi, Heinrich, Bernd, Subramanyam, Varun, Qi, Jonathan, Wabitsch, Simon, Green, Benjamin L., Bauer, Kylynda C., Myojin, Yuta, Greten, Layla T., McCallen, Justin D., Huang, Patrick, Trehan, Rajiv, Wang, Xin, Nur, Amran, Murphy Soika, Dana Qiang, Pouzolles, Marie, Evans, Christine N., Chari, Raj, Kleiner, David E., Telford, William, Dadkhah, Kimia, Ruchinskas, Allison, Stovroff, Merrill K., Kang, Jiman, Oza, Kesha, Ruchirawat, Mathuros, Kroemer, Alexander, Wang, Xin Wei, Claassen, Manfred, Korangy, Firouzeh, and Greten, Tim F.

Published
2023
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6. Interferometric Monitoring of Gamma-ray Bright AGNs: S5 0716+714

Author

Lee, Jee Won, Lee, Sang-Sung, Hodgson, Jeffrey A., Kim, Dae-Won, Algaba, Juan-Carlos, Kang, Sincheol, Kang, Jiman, and Kim, Sungsoo S.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present the results of very long baseline interferometry (VLBI) observations of gamma-ray bright blazar S5 0716+714 using the Korean VLBI Network (KVN) at the 22, 43, 86, and 129 GHz bands, as part of the Interferometric Monitoring of Gamma-ray Bright AGNs (iMOGABA) KVN key science program. Observations were conducted in 29 sessions from January 16, 2013 to March 1, 2016, with the source being detected and imaged at all available frequencies. In all epochs, the source was compact on the milliarcsecond (mas) scale, yielding a compact VLBI core dominating the synchrotron emission on these scales. Based on the multi-wavelength data between 15 GHz (Owens Valley Radio Observatory) and 230 GHz (Submillimeter Array), we found that the source shows multiple prominent enhancements of the flux density at the centimeter (cm) and millimeter (mm) wavelengths, with mm enhancements leading cm enhancements by -16$\pm$8 days. The turnover frequency was found to vary between 21 to 69GHz during our observations. By assuming a synchrotron self-absorption model for the relativistic jet emission in S5 0716+714, we found the magnetic field strength in the mas emission region to be $\le$5 mG during the observing period, yielding a weighted mean of 1.0$\pm$0.6 mG for higher turnover frequencies (e.g., >45 GHz)., Comment: 36 pages, 13 figures, Accepted for publication in ApJ

Published
2017
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7. CD69+ resident memory T cells are associated with graft-versus-host disease in intestinal transplantation

Author

Weiner, Joshua, Svetlicky, Nina, Kang, Jiman, Sadat, Mohammed, Khan, Khalid, Duttargi, Anju, Stovroff, Merrill, Moturi, Sangeetha, Kara Balla, Abdalla, Hyang Kwon, Dong, Kallakury, Bhaskar, Hawksworth, Jason, Subramanian, Sukanya, Yazigi, Nada, Kaufman, Stuart, Pasieka, Helena B., Matsumoto, Cal S., Robson, Simon C., Pavletic, Steven, Zasloff, Michael, Fishbein, Thomas M., and Kroemer, Alexander

Published
2021
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8. Rejection of intestinal allotransplants is driven by memory T helper type 17 immunity and responds to infliximab

Author

Kroemer, Alexander, Belyayev, Leonid, Khan, Khalid, Loh, Katrina, Kang, Jiman, Duttargi, Anju, Dhani, Harmeet, Sadat, Mohammed, Aguirre, Oswaldo, Gusev, Yuriy, Bhuvaneshwar, Krithika, Kallakury, Bhaskar, Cosentino, Christopher, Houlihan, Brenna, Diaz, Jamie, Moturi, Sangeetha, Yazigi, Nada, Kaufman, Stuart, Subramanian, Sukanya, Hawksworth, Jason, Girlanda, Raffaelle, Robson, Simon C., Matsumoto, Cal S., Zasloff, Michael, and Fishbein, Thomas M.

Published
2021
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10. Astrometrically Registered Simultaneous Observations of the 22 GHz H$_2$O and the 43GHz SiO masers towards R Leonis Minoris using KVN and Source/Frequency Phase Referencing

Author

Dodson, Richard, Rioja, María J., Jung, Tae-Hyun, Sohn, Bong-Won, Byun, Do-Young, Cho, Se-Hyung, Lee, Sang-Sung, Kim, Jongsoo, Kim, Kee-Tae, Oh, Chung-Sik, Han, Seog-Tae, Je, Do-Heung, Chung, Moon-Hee, Wi, Seog-Oh, Kang, Jiman, Lee, Jung-Won, Chung, Hyunsoo, Kim, Hyo-Ryoung, Kim, Hyun-Goo, Lee, Chang-Hoon, Roh, Duk-Gyoo, Oh, Se-Jin, Yeom, Jae-Hwan, Song, Min-Gyu, and Kang, Yong-Woo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Oxygen-rich Asymptotic Giant Branch (AGB) stars can be intense emitters of SiO ($v$=1 and 2, J=1$\rightarrow$0) and H$_2$O maser lines at 43 and 22 GHz, respectively. VLBI observations of the maser emission provide a unique tool to probe the innermost layers of the circumstellar envelopes in AGB stars. Nevertheless, the difficulties in achieving astrometrically aligned \water\ and $v$=1 and $v$=2 SiO maser maps have traditionally limited the physical constraints that can be placed on the SiO maser pumping mechanism. We present phase referenced simultaneous spectral-line VLBI images for the SiO $v$=1 and $v$=2, J=1$\rightarrow$0, and H$_2$O maser emission around the AGB star R\,LMi, obtained from the Korean VLBI Network (KVN). The simultaneous multi-channel receivers of the KVN offer great possibilities for astrometry in the frequency domain. With this facility we have produced images with bona-fide absolute astrometric registration between high frequency maser transitions of different species to provide the positions of the \water\ maser emission, and the centre of the SiO maser emission, and hence reducing the uncertainty in the proper motion for R\,LMi by an order of magnitude over that from Hipparcos. This is the first successful demonstration of source frequency phase referencing for mm-VLBI spectral-line observations and also where the ratio between the frequencies is not an integer., Comment: Accepted in AJ

Published
2014
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11. Verification of the Astrometric Performance of the Korean VLBI Network, using comparative SFPR studies with the VLBA at 14/7 mm

Author

Rioja, María J., Dodson, Richard, Jung, TaeHyun, Sohn, Bong Won, Byun, Do-Young, Agudo, Iván, Cho, Se-Hyung, Lee, Sang-Sung, Kim, Jongsoo, Kim, Kee-Tae, Oh, Chung Sik, Han, Seog-Tae, Je, Do-Heung, Chung, Moon-Hee, Wi, Seog-Oh, Kang, Jiman, Lee, Jung-Won, Chung, Hyunsoo, Kim, Hyo Ryoung, Kim, Hyun-Goo, Lee, Chang-Hoon, Roh, Duk-Gyoo, Oh, Se-Jin, Yeom, Jae-Hwan, Song, Min-Gyu, and Kang, Yong-Woo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Korean VLBI Network (KVN) is a new mm-VLBI dedicated array with capability for simultaneous observations at multiple frequencies, up to 129 GHz. The innovative multi-channel receivers present significant benefits for astrometric measurements in the frequency domain. The aim of this work is to verify the astrometric performance of the KVN using a comparative study with the VLBA, a well established instrument. For that purpose, we carried out nearly contemporaneous observations with the KVN and the VLBA, at 14/7 mm, in April 2013. The KVN observations consisted of simultaneous dual frequency observations, while the VLBA used fast frequency switching observations. We used the Source Frequency Phase Referencing technique for the observational and analysis strategy. We find that having simultaneous observations results in a superior performance for compensation of all atmospheric terms in the observables, in addition to offering other significant benefits for astrometric analysis. We have compared the KVN astrometry measurements to those from the VLBA. We find that the structure blending effects introduce dominant systematic astrometric shifts and these need to be taken into account. We have tested multiple analytical routes to characterize the impact of the low resolution effects for extended sources in the astrometric measurements. The results from the analysis of KVN and full VLBA datasets agree within 2-$\sigma$ of the thermal error estimate. We interpret the discrepancy as arising from the different resolutions. We find that the KVN provides astrometric results with excellent agreement, within 1-$\sigma$, when compared to a VLBA configuration which has a similar resolution. Therefore this comparative study verifies the astrometric performance of KVN using SFPR at 14/7 mm, and validates the KVN as an astrometric instrument., Comment: Accepted AJ

Published
2014
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12. VLBI observations of bright AGN jets with KVN and VERA Array (KaVA): Evaluation of Imaging Capability

Author

Niinuma, Kotaro, Lee, Sang-Sung, Kino, Motoki, Sohn, Bong Won, Akiyama, Kazunori, Zhao, Guang-Yao, Sawada-Satoh, Satoko, Trippe, Sascha, Hada, Kazuhiro, Jung, Taehyun, Hagiwara, Yoshiaki, Dodson, Richard, Koyama, Shoko, Honma, Mareki, Nagai, Hiroshi, Chung, Aeree, Doi, Akihiro, Fujisawa, Kenta, Han, Myoung-Hee, Kim, Joeng-Sook, Lee, Jeewon, Lee, Jeong Ae, Miyazaki, Atsushi, Oyama, Tomoaki, Sorai, Kazuo, Wajima, Kiyoaki, Bae, Jaehan, Byun, Do-Young, Cho, Se-Hyung, Choi, Yoon Kyung, Chung, Hyunsoo, Chung, Moon-Hee, Han, Seog-Tae, Hirota, Tomoya, Hwang, Jung-Wook, Je, Do-Heung, Jike, Takaaki, Jung, Dong-Kyu, Jung, Jin-Seung, Kang, Ji-Hyun, Kang, Jiman, Kang, Yong-Woo, Kan-ya, Yukitoshi, Kanaguchi, Masahiro, Kawaguchi, Noriyuki, Kim, Bong Gyu, Kim, Hyo Ryoung, Kim, Hyun-Goo, Kim, Jaeheon, Kim, Jongsoo, Kim, Kee-Tae, Kim, Mikyoung, Kobayashi, Hideyuki, Kono, Yusuke, Kurayama, Tomoharu, Lee, Changhoon, Lee, Jung-Won, Lee, Sang Hyun, Minh, Young Chol, Matsumoto, Naoko, Nakagawa, Akiharu, Oh, Chung Sik, Oh, Se-Jin, Park, Sun-Youp, Roh, Duk-Gyoo, Sasao, Tetsuo, Shibata, Katsunori M., Song, Min-Gyu, Tamura, Yoshiaki, Wi, Seog-Oh, Yeom, Jae-Hwan, and Yun, Young Joo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Korean very-long-baseline interferometry (VLBI) network (KVN) and VLBI Exploration of Radio Astrometry (VERA) Array (KaVA) is the first international VLBI array dedicated to high-frequency (23 and 43 GHz bands) observations in East Asia. Here, we report the first imaging observations of three bright active galactic nuclei (AGNs) known for their complex morphologies: 4C 39.25, 3C 273, and M 87. This is one of the initial result of KaVA early science. Our KaVA images reveal extended outflows with complex substructure such as knots and limb brightening, in agreement with previous Very Long Baseline Array (VLBA) observations. Angular resolutions are better than 1.4 and 0.8 milliarcsecond at 23 GHz and 43 GHz, respectively. KaVA achieves a high dynamic range of ~1000, more than three times the value achieved by VERA. We conclude that KaVA is a powerful array with a great potential for the study of AGN outflows, at least comparable to the best existing radio interferometric arrays., Comment: 15 pages, 10 figures, 6 tables, accepted for publication in PASJ

Published
2014
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13. The First Very Long Baseline Interferometry Image of 44 GHz Methanol Maser with the KVN and VERA Array (KaVA)

Author

Matsumoto, Naoko, Hirota, Tomoya, Sugiyama, Koichiro, Kim, Kee-Tae, Kim, Mikyoung, Byun, Do-Young, Jung, Taehyun, Chibueze, James O., Honma, Mareki, Kameya, Osamu, Kim, Jongsoo, Lyo, A-Ran, Motogi, Kazuhito, Oh, Chungsik, Shino, Nagisa, Sunada, Kazuyoshi, Bae, Jaehan, Chung, Hyunsoo, Chung, Moon-Hee, Cho, Se-Hyung, Han, Myoung-Hee, Han, Seog-Tae, Hwang, Jung-Wook, Je, Do-Heung, Jike, Takaaki, Jung, Dong-Kyu, Jung, Jin-seung, Kang, Ji-hyun, Kang, Jiman, Kang, Yong-Woo, Kan-ya, Yukitoshi, Kawaguchi, Noriyuki, Kim, Bong Gyu, Kim, Jaeheon, Kim, Hyo Ryoung, Kim, Hyun-Goo, Kobayashi, Hideyuki, Kono, Yusuke, Kurayama, Tomoharu, Lee, Changhoon, Lee, Jeong Ae, Lee, Jeewon, Lee, Jung-Won, Lee, Sang Hyun, Lee, Sang-Sung, Minh, Young Chol, Miyazaki, Atsushi, Oh, Se-Jin, Oyama, Tomoaki, Park, Sun-youp, Roh, Duk-Gyoo, Sasao, Tetsuo, Sawada-Satoh, Satoko, Shibata, Katsunori M., Sohn, Bong Won, Song, Min-Gyu, Tamura, Yoshiaki, Wajima, Kiyoaki, Wi, Seog-Oh, Yeom, Jae-Hwan, and Yun, Young Joo

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We have carried out the first very long baseline interferometry (VLBI) imaging of 44 GHz class I methanol maser (7_{0}-6_{1}A^{+}) associated with a millimeter core MM2 in a massive star-forming region IRAS 18151-1208 with KaVA (KVN and VERA Array), which is a newly combined array of KVN (Korean VLBI Network) and VERA (VLBI Exploration of Radio Astrometry). We have succeeded in imaging compact maser features with a synthesized beam size of 2.7 milliarcseconds x 1.5 milliarcseconds (mas). These features are detected at a limited number of baselines within the length of shorter than approximately 650 km corresponding to 100 Mlambda in the uv-coverage. The central velocity and the velocity width of the 44 GHz methanol maser are consistent with those of the quiescent gas rather than the outflow traced by the SiO thermal line. The minimum component size among the maser features is ~ 5 mas x 2 mas, which corresponds to the linear size of ~ 15 AU x 6 AU assuming a distance of 3 kpc. The brightness temperatures of these features range from ~ 3.5 x 10^{8} to 1.0 x 10^{10} K, which are higher than estimated lower limit from a previous Very Large Array observation with the highest spatial resolution of ~ 50 mas. The 44 GHz class I methanol maser in IRAS 18151-1208 is found to be associated with the MM2 core, which is thought to be less evolved than another millimeter core MM1 associated with the 6.7 GHz class II methanol maser., Comment: 19 pages, 3 figures

Published
2014
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14. Early science with Korean VLBI network: the QCAL-1 43GHz calibrator survey

Author

Petrov, Leonid, Lee, Sang-Sung, Kim, Jongsoo, Jung, Taehyun, Oh, Junghwan, Sohn, Bong Won, Byun, Do-Young, Chung, Moon-Hee, Je, Do-Heung, Wi, Seog-Oh, Song, Min-Gyu, Kang, Jiman, Han, Seog-Tae, Lee, Jung-Won, Kim, Bong Gyu, Chung, Hyunsoo, and Kim, Hyun-Goo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

This paper presents the catalog of correlated flux densities in three ranges of baseline projection lengths of 637 sources from a 43 GHz (Q-band) survey observed with the Korean VLBI Network. Of them, 623 sources have not been observed before at Q-band with VLBI. The goal of this work in the early science phase of the new VLBI array is twofold: to evaluate the performance of the new instrument that operates in a frequency range of 22-129 GHz and to build a list of objects that can be used as targets and as calibrators. We have observed the list of 799 target sources with declinations down to -40 degrees. Among them, 724 were observed before with VLBI at 22 GHz and had correlated flux densities greater than 200 mJy. The overall detection rate is 78%. The detection limit, defined as the minimum flux density for a source to be detected with 90% probability in a single observation, was in a range of 115-180 mJy depending on declination. However, some sources as weak as 70 mJy have been detected. Of 623 detected sources, 33 objects are detected for the first time in VLBI mode. We determined their coordinates with the median formal uncertainty 20 mas. The results of this work set the basis for future efforts to build the complete flux-limited sample of extragalactic sources at frequencies 22 GHz and higher at 3/4 of the celestial sphere., Comment: Accepted for publication by the Astronomical Journal; 6 pages. Machine-readable Table 3 and Table 4 can be accessed by downloading and uncompressing source code of the paper

Published
2012
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15. Single dish performance of KVN 21-m radio telescopes:Simultaneous observations at 22 and 43 GHz

Author

Lee, Sang-Sung, Byun, Do-Young, Oh, Chung Sik, Han, Seog-Tae, Je, Do-Heung, Kim, Kee-Tae, Wi, Seog-Oh, Cho, Se-Hyung, Sohn, Bong Won, Kim, Jaeheon, Lee, Jeewon, Oh, Se-Jin, Song, Min-Gyu, Kang, Jiman, Jung, Moon-Hee, Lee, Jeong Ae, Oh, Junghwan, Bae, Jae-Han, Yun, So-Young, Lee, Jung-Won, Kim, Bong Gyu, Chung, Hyunsoo, Roh, Duk-Gyoo, Lee, Chang Hoon, Kim, Hyun Goo, Kim, Hyo Ryoung, Yeom, Jae-Hwan, Kurayama, Tomoharu, Jung, Taehyun, Park, Pulun, Kim, Min Joong, Yoon, Dong-Hwan, and Kim, Won-Ju

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We report simultaneous multi-frequency observing performance at 22 and 43 GHz of the 21-m shaped-Cassegrain radio telescopes of the Korean VLBI Network (KVN). KVN is the first millimeter-dedicated VLBI network in Korea having a maximum baseline length of 480 km. It currently operates at 22 and 43 GHz and planed to operate in four frequency bands, 22, 43, 86, and 129 GHz. The unique quasioptics of KVN enable simultaneous multi-frequency observations based on efficient beam filtering and accuarate antenna-beam alignment at 22 and 43 GHz. We found that the offset of the beams is within <5 arcseconds over all pointing directions of antenna. The dual polarization, cooled HEMT receivers at 22 and 43 GHz result in receiver noise temperatures less than 40 K at 21.25-23.25 GHz and 80 K at 42.11-44.11 GHz. The pointing accuracies have been measured to be 3 arcseconds in azimuth and elevation for all antennas. The measured aperture efficiencies are 65%(K)/67%(Q), 62%(K)/59%(Q), and 66%(K)/60%(Q) for the three KVN antennas, KVNYS, KVNUS, and KVNTN, respectively. The main-beam efficiencies are measured to be 50%(K)/52%(Q), 48%(K)/50%(Q), and 50%(K)/47%(Q) for KVNYS, KVNUS, and KVNTN, respectively. The estimated Moon efficiencies are 77%(K)/90%(Q), 74%(K)/79%(Q), and 80%(K)/86%(Q) for KVNYS, KVNUS, KVNTN, respectively. The elevation dependence of the aperture efficiencies is quite flat for elevations > 20 degrees., Comment: 33 pages, 10 figures, 9 tables, Accepted for publication in PASP

Published
2011
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16. 16: RNA Sequencing (RNA-seq) Analysis Provides for Gene Signatures Specific to Intestinal Transplant Rejection

Author

Kang, Jiman, primary, Patil, Digvijay, additional, Oza, Kesha, additional, Liggett, Jedson, additional, Belyayev, Leonid, additional, Aguirre, Oswaldo, additional, Khan, Khalid, additional, Gusev, Yuriy, additional, Bhuvaneshwar, Krithika, additional, Ressom, Habtom, additional, Matsumoto, Cal, additional, Fishbein, Thomas, additional, and Kroemer, Alexander, additional

Published
2023
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17. 26: Inflammasome Activation Involved in the Early Inflammation following Intestinal Transplantation: Implications in Acute Rejection

Author

Kang, Jiman, primary, Patil, Digvijay, additional, Oza, Kesha, additional, Ligget, Jedson, additional, Belyayev, Leonid, additional, Aguirre, Oswaldo, additional, Khan, Khalid, additional, Gusev, Yuriy, additional, Bhuvaneshwar, Krithika, additional, Ressom, Habtom, additional, Matsumoto, Cal, additional, Fishbein, Thomas, additional, and Kroemer, Alexander, additional

Published
2023
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24. 1019 CSF1R+PD-L1+tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin

Author

Ruf, Benjamin, primary, Bruhns, Matthias, additional, Babaei, Sepideh, additional, Kedei, Noemi, additional, Ma, Chi, additional, Ma, Lichun, additional, Revsine, Mahler, additional, Heinrich, Bernd, additional, Subramanyam, Varun, additional, Qi, Jonathan, additional, Wabitsch, Simon, additional, Green, Benjamin, additional, Bauer, Kylynda, additional, Myojin, Yuta, additional, Benmebarek, Mohamed-Reda, additional, Greten, Layla, additional, McCallen, Justin, additional, Huang, Patrick, additional, Pouzolles, Marie, additional, Kleiner, David, additional, Telford, William, additional, Dadkhah, Kimia, additional, Ruchinskas, Allison, additional, Stoffroff, Merrill, additional, Kang, Jiman, additional, Oza, Kesha, additional, Ruchirawat, Mathuros, additional, Kroemer, Alexander, additional, Wang, Xin, additional, Claassen, Manfred, additional, Korangy, Firouzeh, additional, and Greten, Tim, additional

Published
2022
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25. Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers

Author

Liggett, Jedson R., primary, Kang, Jiman, additional, Ranjit, Suman, additional, Rodriguez, Olga, additional, Loh, Katrina, additional, Patil, Digvijay, additional, Cui, Yuki, additional, Duttargi, Anju, additional, Nguyen, Sang, additional, He, Britney, additional, Lee, Yichien, additional, Oza, Kesha, additional, Frank, Brett S., additional, Kwon, DongHyang, additional, Li, Heng-Hong, additional, Kallakury, Bhaskar, additional, Libby, Andrew, additional, Levi, Moshe, additional, Robson, Simon C., additional, Fishbein, Thomas M., additional, Cui, Wanxing, additional, Albanese, Chris, additional, Khan, Khalid, additional, and Kroemer, Alexander, additional

Published
2022
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26. Type 1 Innate Lymphoid Cells Are Proinflammatory Effector Cells in Ischemia-Reperfusion Injury of Steatotic Livers

Author

Kang, Jiman, primary, Liggett, Jedson R., additional, Patil, Digvijay, additional, Ranjit, Suman, additional, Loh, Katrina, additional, Duttargi, Anju, additional, Cui, Yuki, additional, Oza, Kesha, additional, Frank, Brett S., additional, Kwon, DongHyang, additional, Kallakury, Bhaskar, additional, Robson, Simon C., additional, Fishbein, Thomas M., additional, Cui, Wanxing, additional, Khan, Khalid, additional, and Kroemer, Alexander, additional

Published
2022
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27. Abstract 2106: Spatially resolved immune cell atlas of human liver cancer identifies the cellular interaction network underlying mucosal-associated invariant T (MAIT) cell dysfunction in hepatocellular carcinoma

Author

Ruf, Benjamin, primary, Kedei, Noemi, additional, Bruhns, Matthias, additional, Babaei, Sepideh, additional, Heinrich, Bernd, additional, Subramanyam, Varun, additional, Ma, Chi, additional, Wabitsch, Simon, additional, Green, Benjamin, additional, Bauer, Kylynda C., additional, Myojin, Yuta, additional, Qi, Jonathan, additional, Nur, Amran, additional, McCallen, Justin, additional, Greten, Layla, additional, Telford, William G., additional, Stovroff, Merrill K., additional, Oza, Kesha, additional, Kang, Jiman, additional, Kroemer, Alexander, additional, Claassen, Manfred, additional, Korangy, Firouzeh, additional, and Greten, Tim F., additional

Published
2022
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29. The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma

Author

Heinrich, Bernd, primary, Gertz, E Michael, additional, Schäffer, Alejandro A, additional, Craig, Amanda, additional, Ruf, Benjamin, additional, Subramanyam, Varun, additional, McVey, John C, additional, Diggs, Laurence P, additional, Heinrich, Sophia, additional, Rosato, Umberto, additional, Ma, Chi, additional, Yan, Chunhua, additional, Hu, Ying, additional, Zhao, Yongmei, additional, Shen, Tsai-Wei, additional, Kapoor, Veena, additional, Telford, William, additional, Kleiner, David E, additional, Stovroff, Merril K, additional, Dhani, Harmeet S, additional, Kang, Jiman, additional, Fishbein, Thomas, additional, Wang, Xin Wei, additional, Ruppin, E, additional, Kroemer, Alexander, additional, Greten, Tim F, additional, and Korangy, Firouzeh, additional

Published
2021
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30. Operational tolerance in intestinal transplantation

Author

Kroemer, Alexander, primary, Khan, Khalid, additional, Kaufman, Stuart S., additional, Kang, Jiman, additional, Weiner, Joshua, additional, Duttargi, Anju, additional, Belyayev, Leonid, additional, Ashokkumar, Chethan, additional, Sindhi, Rakesh, additional, Timofeeva, Olga A., additional, Zasloff, Michael, additional, Matsumoto, Cal S., additional, and Fishbein, Thomas M., additional

Published
2021
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34. The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma

Author

Heinrich, Bernd, Gertz, E Michael, Scha¨ffer, Alejandro A, Craig, Amanda, Ruf, Benjamin, Subramanyam, Varun, McVey, John C, Diggs, Laurence P, Heinrich, Sophia, Rosato, Umberto, Ma, Chi, Yan, Chunhua, Hu, Ying, Zhao, Yongmei, Shen, Tsai-Wei, Kapoor, Veena, Telford, William, Kleiner, David E, Stovroff, Merril K, Dhani, Harmeet S, Kang, Jiman, Fishbein, Thomas, Wang, Xin Wei, Ruppin, E, Kroemer, Alexander, Greten, Tim F, and Korangy, Firouzeh

Abstract

ObjectiveHepatocellular carcinoma (HCC) represents a typical inflammation-associated cancer. Tissue resident innate lymphoid cells (ILCs) have been suggested to control tumour surveillance. Here, we studied how the local cytokine milieu controls ILCs in HCC.DesignWe performed bulk RNA sequencing of HCC tissue as well as flow cytometry and single-cell RNA sequencing of enriched ILCs from non-tumour liver, margin and tumour core derived from 48 patients with HCC. Simultaneous measurement of protein and RNA expression at the single-cell level (AbSeq) identified precise signatures of ILC subgroups. In vitro culturing of ILCs was used to validate findings from in silico analysis. Analysis of RNA-sequencing data from large HCC cohorts allowed stratification and survival analysis based on transcriptomic signatures.ResultsRNA sequencing of tumour, non-tumour and margin identified tumour-dependent gradients, which were associated with poor survival and control of ILC plasticity. Single-cell RNA sequencing and flow cytometry of ILCs from HCC livers identified natural killer (NK)-like cells in the non-tumour tissue, losing their cytotoxic profile as they transitioned into tumour ILC1 and NK-like-ILC3 cells. Tumour ILC composition was mediated by cytokine gradients that directed ILC plasticity towards activated tumour ILC2s. This was liver-specific and not seen in ILCs from peripheral blood mononuclear cells. Patients with high ILC2/ILC1 ratio expressed interleukin-33 in the tumour that promoted ILC2 generation, which was associated with better survival.ConclusionOur results suggest that the tumour cytokine milieu controls ILC composition and HCC outcome. Specific changes of cytokines modify ILC composition in the tumour by inducing plasticity and alter ILC function.

Published
2022
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36. VLBI observations of bright AGN jets with KVN and VERA Array (KaVA): Evaluation of Imaging Capability

Author

Kang, Jiman, Kang, Yong-Woo, Kan-ya, Yukitoshi, Kim, Bong Gyu, Kim, Hyo Ryoung, Kim, Hyun-Goo, Kim, Jaeheon, Kim, Jongsoo, Kim, Kee-Tae, Kim, Mikyoung, Lee, Changhoon, Lee, Jung-Won, Lee, Sang Hyun, Minh, Young Chol, Lee, Sang-Sung, Sohn, Bong Won, Zhao, Guang-Yao, Trippe, Sascha, Jung, Taehyun, Dodson, Richard, Chung, Aeree, Han, Myoung-Hee, Kim, Joeng-Sook, Lee, Jeewon, Lee, Jeong Ae, Bae, Jaehan, Byun, Do-Young, Cho, Se-Hyung, Choi, Yoon Kyung, Chung, Hyunsoo, Chung, Moon-Hee, Han, Seog-Tae, Hwang, Jung-Wook, Je, Do-Heung, Jung, Dong-Kyu, Jung, Jin-Seung, Kang, Ji-Hyun, Niinuma, Kotaro, Kino, Motoki, Akiyama, Kazunori, Sawada-Satoh, Satoko, Hada, Kazuhiro, Hagiwara, Yoshiaki, Koyama, Shoko, Honma, Mareki, Nagai, Hiroshi, Doi, Akihiro, Fujisawa, Kenta, Miyazaki, Atsushi, Oyama, Tomoaki, Sorai, Kazuo, Wajima, Kiyoaki, Hirota, Tomoya, Jike, Takaaki, Kanaguchi, Masahiro, Kawaguchi, Noriyuki, Kobayashi, Hideyuki, Kono, Yusuke, Kurayama, Tomoharu, and Matsumoto, Naoko

Subjects
radio continuum: galaxies, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Active galactic nucleus, galaxies: active, Astronomy, FOS: Physical sciences, Astronomy and Astrophysics, Astrometry, galaxies: jets, Interferometry, techniques: interferometric, Space and Planetary Science, Very-long-baseline interferometry, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Instrumentation and Methods for Astrophysics (astro-ph.IM), Very Long Baseline Array
Abstract

著者人数: 72名, Accepted: 2014-06-10, 資料番号: SA1005019000

Published
2014
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37. SiO MASERS AROUND WX PSC MAPPED WITH THE KVN AND VERA ARRAY (KaVA)

Author

Yun, Youngjoo, primary, Cho, Se-Hyung, additional, Imai, Hiroshi, additional, Kim, Jaeheon, additional, Asaki, Yoshiharu, additional, Chibueze, James O., additional, Choi, Yoon Kyung, additional, Dodson, Richard, additional, Kim, Dong-Jin, additional, Kusuno, Kozue, additional, Matsumoto, Naoko, additional, Min, Cheulhong, additional, Oyadomari, Miyako, additional, Rioja, María J., additional, Yoon, Dong-Hwan, additional, Byun, Do-Young, additional, Chung, Hyunsoo, additional, Chung, Moon-Hee, additional, Hagiwara, Yoshiaki, additional, Han, Myoung-Hee, additional, Han, Seog-Tae, additional, Hirota, Tomoya, additional, Honma, Mareki, additional, Hwang, Jung-Wook, additional, Je, Do-Heung, additional, Jike, Takaaki, additional, Jung, Dong-Kyu, additional, Jung, Taehyun, additional, Kang, Ji-Hyun, additional, Kang, Jiman, additional, Kang, Yong-Woo, additional, Kan-ya, Yukitoshi, additional, Kanaguchi, Masahiro, additional, Kawaguchi, Noriyuki, additional, Kim, Bong Gyu, additional, Kim, Hyo Ryoung, additional, Kim, Hyun-Goo, additional, Kim, Jongsoo, additional, Kim, Kee-Tae, additional, Kim, Mikyoung, additional, Kobayashi, Hideyuki, additional, Kono, Yusuke, additional, Kurayama, Tomoharu, additional, Lee, Changhoon, additional, Lee, Jeewon, additional, Lee, Jeong Ae, additional, Lee, Jung-Won, additional, Lee, Sang Hyun, additional, Lee, Sang-Sung, additional, Lyo, A-Ran, additional, Minh, Young Chol, additional, Oh, Chungsik, additional, Oh, Se-Jin, additional, Oyama, Tomoaki, additional, Roh, Duk-Gyoo, additional, Sawada-Satoh, Satoko, additional, Shibata, Katsunori M., additional, Sohn, Bong Won, additional, Song, Min-Gyu, additional, Tamura, Yoshiaki, additional, Wi, Seog-Oh, additional, and Yeom, Jae-Hwan, additional

Published
2016
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40. VLBI observations of bright AGN jets with the KVN and VERA Array (KaVA): Evaluation of imaging capability

Author

Niinuma, Kotaro, primary, Lee, Sang-Sung, additional, Kino, Motoki, additional, Sohn, Bong Won, additional, Akiyama, Kazunori, additional, Zhao, Guang-Yao, additional, Sawada-Satoh, Satoko, additional, Trippe, Sascha, additional, Hada, Kazuhiro, additional, Jung, Taehyun, additional, Hagiwara, Yoshiaki, additional, Dodson, Richard, additional, Koyama, Shoko, additional, Honma, Mareki, additional, Nagai, Hiroshi, additional, Chung, Aeree, additional, Doi, Akihiro, additional, Fujisawa, Kenta, additional, Han, Myoung-Hee, additional, Kim, Joeng-Sook, additional, Lee, Jeewon, additional, Lee, Jeong Ae, additional, Miyazaki, Atsushi, additional, Oyama, Tomoaki, additional, Sorai, Kazuo, additional, Wajima, Kiyoaki, additional, Bae, Jaehan, additional, Byun, Do-Young, additional, Cho, Se-Hyung, additional, Choi, Yoon Kyung, additional, Chung, Hyunsoo, additional, Chung, Moon-Hee, additional, Han, Seog-Tae, additional, Hirota, Tomoya, additional, Hwang, Jung-Wook, additional, Je, Do-Heung, additional, Jike, Takaaki, additional, Jung, Dong-Kyu, additional, Jung, Jin-Seung, additional, Kang, Ji-Hyun, additional, Kang, Jiman, additional, Kang, Yong-Woo, additional, Kan-ya, Yukitoshi, additional, Kanaguchi, Masahiro, additional, Kawaguchi, Noriyuki, additional, Kim, Bong Gyu, additional, Kim, Hyo Ryoung, additional, Kim, Hyun-Goo, additional, Kim, Jaeheon, additional, Kim, Jongsoo, additional, Kim, Kee-Tae, additional, Kim, Mikyoung, additional, Kobayashi, Hideyuki, additional, Kono, Yusuke, additional, Kurayama, Tomoharu, additional, Lee, Changhoon, additional, Lee, Jung-Won, additional, Lee, Sang Hyun, additional, Minh, Young Chol, additional, Matsumoto, Naoko, additional, Nakagawa, Akiharu, additional, Oh, Chung Sik, additional, Oh, Se-Jin, additional, Park, Sun-Youp, additional, Roh, Duk-Gyoo, additional, Sasao, Tetsuo, additional, Shibata, Katsunori M., additional, Song, Min-Gyu, additional, Tamura, Yoshiaki, additional, Wi, Seog-Oh, additional, Yeom, Jae-Hwan, additional, and Yun, Young Joo, additional

Published
2014
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41. ASTROMETRICALLY REGISTERED SIMULTANEOUS OBSERVATIONS OF THE 22 GHz H2O AND 43 GHz SiO MASERS TOWARD R LEONIS MINORIS USING KVN AND SOURCE/FREQUENCY PHASE REFERENCING

Author

Dodson, Richard, primary, Rioja, María J., additional, Jung, Tae-Hyun, additional, Sohn, Bong-Won, additional, Byun, Do-Young, additional, Cho, Se-Hyung, additional, Lee, Sang-Sung, additional, Kim, Jongsoo, additional, Kim, Kee-Tae, additional, Oh, Chung-Sik, additional, Han, Seog-Tae, additional, Je, Do-Heung, additional, Chung, Moon-Hee, additional, Wi, Seog-Oh, additional, Kang, Jiman, additional, Lee, Jung-Won, additional, Chung, Hyunsoo, additional, Kim, Hyo-Ryoung, additional, Kim, Hyun-Goo, additional, Lee, Chang-Hoon, additional, Roh, Duk-Gyoo, additional, Oh, Se-Jin, additional, Yeom, Jae-Hwan, additional, Song, Min-Gyu, additional, and Kang, Yong-Woo, additional

Published
2014
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42. VERIFICATION OF THE ASTROMETRIC PERFORMANCE OF THE KOREAN VLBI NETWORK, USING COMPARATIVE SFPR STUDIES WITH THE VLBA AT 14/7 mm

Author

Rioja, María J., primary, Dodson, Richard, additional, Jung, TaeHyun, additional, Sohn, Bong Won, additional, Byun, Do-Young, additional, Agudo, Iván, additional, Cho, Se-Hyung, additional, Lee, Sang-Sung, additional, Kim, Jongsoo, additional, Kim, Kee-Tae, additional, Oh, Chung Sik, additional, Han, Seog-Tae, additional, Je, Do-Heung, additional, Chung, Moon-Hee, additional, Wi, Seog-Oh, additional, Kang, Jiman, additional, Lee, Jung-Won, additional, Chung, Hyunsoo, additional, Kim, Hyo Ryoung, additional, Kim, Hyun-Goo, additional, Lee, Chang-Hoon, additional, Roh, Duk-Gyoo, additional, Oh, Se-Jin, additional, Yeom, Jae-Hwan, additional, Song, Min-Gyu, additional, and Kang, Yong-Woo, additional

Published
2014
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43. THE FIRST VERY LONG BASELINE INTERFEROMETRY IMAGE OF A 44 GHz METHANOL MASER WITH THE KVN AND VERA ARRAY (KaVA)

Author

Matsumoto, Naoko, primary, Hirota, Tomoya, additional, Sugiyama, Koichiro, additional, Kim, Kee-Tae, additional, Kim, Mikyoung, additional, Byun, Do-Young, additional, Jung, Taehyun, additional, Chibueze, James O., additional, Honma, Mareki, additional, Kameya, Osamu, additional, Kim, Jongsoo, additional, Lyo, A-Ran, additional, Motogi, Kazuhito, additional, Oh, Chungsik, additional, Shino, Nagisa, additional, Sunada, Kazuyoshi, additional, Bae, Jaehan, additional, Chung, Hyunsoo, additional, Chung, Moon-Hee, additional, Cho, Se-Hyung, additional, Han, Myoung-Hee, additional, Han, Seog-Tae, additional, Hwang, Jung-Wook, additional, Je, Do-Heung, additional, Jike, Takaaki, additional, Jung, Dong-Kyu, additional, Jung, Jin-seung, additional, Kang, Ji-hyun, additional, Kang, Jiman, additional, Kang, Yong-Woo, additional, Kan-ya, Yukitoshi, additional, Kawaguchi, Noriyuki, additional, Kim, Bong Gyu, additional, Kim, Jaeheon, additional, Kim, Hyo Ryoung, additional, Kim, Hyun-Goo, additional, Kobayashi, Hideyuki, additional, Kono, Yusuke, additional, Kurayama, Tomoharu, additional, Lee, Changhoon, additional, Lee, Jeong Ae, additional, Lee, Jeewon, additional, Lee, Jung-Won, additional, Lee, Sang Hyun, additional, Lee, Sang-Sung, additional, Minh, Young Chol, additional, Miyazaki, Atsushi, additional, Oh, Se-Jin, additional, Oyama, Tomoaki, additional, Park, Sun-youp, additional, Roh, Duk-Gyoo, additional, Sasao, Tetsuo, additional, Sawada-Satoh, Satoko, additional, Shibata, Katsunori M., additional, Sohn, Bong Won, additional, Song, Min-Gyu, additional, Tamura, Yoshiaki, additional, Wajima, Kiyoaki, additional, Wi, Seog-Oh, additional, Yeom, Jae-Hwan, additional, and Yun, Young Joo, additional

Published
2014
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44. EARLY SCIENCE WITH THE KOREAN VLBI NETWORK: EVALUATION OF SYSTEM PERFORMANCE

Author

Lee, Sang-Sung, primary, Petrov, Leonid, additional, Byun, Do-Young, additional, Kim, Jongsoo, additional, Jung, Taehyun, additional, Song, Min-Gyu, additional, Oh, Chung Sik, additional, Roh, Duk-Gyoo, additional, Je, Do-Heung, additional, Wi, Seog-Oh, additional, Sohn, Bong Won, additional, Oh, Se-Jin, additional, Kim, Kee-Tae, additional, Yeom, Jae-Hwan, additional, Chung, Moon-Hee, additional, Kang, Jiman, additional, Han, Seog-Tae, additional, Lee, Jung-Won, additional, Kim, Bong Gyu, additional, Chung, Hyunsoo, additional, Kim, Hyun-Goo, additional, Kim, Hyo Ryoung, additional, Kang, Yong-Woo, additional, and Cho, Se-Hyung, additional

Published
2014
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46. EARLY SCIENCE WITH THE KOREAN VLBI NETWORK: THE QCAL-1 43 GHz CALIBRATOR SURVEY

Author

Petrov, Leonid, primary, Lee, Sang-Sung, additional, Kim, Jongsoo, additional, Jung, Taehyun, additional, Oh, Junghwan, additional, Sohn, Bong Won, additional, Byun, Do-Young, additional, Chung, Moon-Hee, additional, Je, Do-Heung, additional, Wi, Seog-Oh, additional, Song, Min-Gyu, additional, Kang, Jiman, additional, Han, Seog-Tae, additional, Lee, Jung-Won, additional, Kim, Bong Gyu, additional, Chung, Hyunsoo, additional, and Kim, Hyun-Goo, additional

Published
2012
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48. Single-Dish Performance of KVN 21 m Radio Telescopes: Simultaneous Observations at 22 and 43 GHz

Author

Lee, Sang-Sung, primary, Byun, Do-Young, additional, Oh, Chung Sik, additional, Han, Seog-Tae, additional, Je, Do-Heung, additional, Kim, Kee-Tae, additional, Wi, Seog-Oh, additional, Cho, Se-Hyung, additional, Sohn, Bong Won, additional, Kim, Jaeheon, additional, Lee, Jeewon, additional, Oh, Se-Jin, additional, Song, Min-Gyu, additional, Kang, Jiman, additional, Chung, Moon-Hee, additional, Lee, Jeong Ae, additional, Oh, Junghwan, additional, Bae, Jae-Han, additional, Yun, So-Young, additional, Lee, Jung-Won, additional, Kim, Bong Gyu, additional, Chung, Hyunsoo, additional, Roh, Duk-Gyoo, additional, Lee, Chang Hoon, additional, Kim, Hyun Goo, additional, Kim, Hyo Ryoung, additional, Yeom, Jae-Hwan, additional, Kurayama, Tomoharu, additional, Jung, Taehyun, additional, Park, Pulun, additional, Kim, Min Joong, additional, Yoon, Dong-Hwan, additional, and Kim, Won-Ju, additional

Published
2011
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