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401 results on '"Kang, Heemin"'

17. Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Author

Lee, Sungkyu, Yoo, Jounghyun, Bae, Gunhyu, Thangam, Ramar, Heo, Jeongyun, Park, Jung Yeon, Choi, Honghwan, Kim, Chowon, An, Jusung, Kim, Jungryun, Mun, Kwang Rok, Shin, Seungyong, Zhang, Kunyu, Zhao, Pengchao, Kim, Yuri, Kang, Nayeon, Han, Seong-Beom, Kim, Dahee, Yoon, Jiwon, Kang, Misun, Kim, Jihwan, Yang, Letao, Karamikamkar, Solmaz, Kim, Jinjoo, Zhu, Yangzhi, Najafabadi, Alireza Hassani, Song, Guosheng, Kim, Dong-Hwee, Lee, Ki-Bum, Oh, Soong Ju, Jung, Hyun-Do, Song, Hyun-Cheol, Jang, Woo Young, Bian, Liming, Chu, Zhiqin, Yoon, Juyoung, Kim, Jong Seung, Zhang, Yu Shrike, Kim, Yongju, Jang, Ho Seong, Kim, Sehoon, and Kang, Heemin

Published
2024
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21. Injectable hydrogels for personalized cancer immunotherapies

Author

Mohaghegh, Neda, Ahari, Amir, Zehtabi, Fatemeh, Buttles, Claire, Davani, Saya, Hoang, Hanna, Tseng, Kaylee, Zamanian, Benjamin, Khosravi, Safoora, Daniali, Ariella, Kouchehbaghi, Negar Hosseinzadeh, Thomas, Isabel, Serati Nouri, Hamed, Khorsandi, Danial, Abbasgholizadeh, Reza, Akbari, Mohsen, Patil, Rameshwar, Kang, Heemin, Jucaud, Vadim, Khademhosseini, Ali, and Hassani Najafabadi, Alireza

Published
2023
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33. Advanced Ultrasound Energy Transfer Technologies using Metamaterial Structures.

Author

Imani, Iman M., Kim, Hyun Soo, Shin, Joonchul, Lee, Dong‐Gyu, Park, Jiwon, Vaidya, Anish, Kim, Chowon, Baik, Jeong Min, Zhang, Yu Shrike, Kang, Heemin, Hur, Sunghoon, and Song, Hyun‐Cheol

Subjects
ENERGY transfer, TECHNOLOGY transfer, NANOGENERATORS, ENGINEERING design, ULTRASONIC imaging
Abstract

Wireless energy transfer (WET) based on ultrasound‐driven generators with enormous beneficial functions, is technologically in progress by the valuation of ultrasonic metamaterials (UMMs) in science and engineering domains. Indeed, novel metamaterial structures can develop the efficiency of mechanical and physical features of ultrasound energy receivers (US‐ETs), including ultrasound‐driven piezoelectric and triboelectric nanogenerators (US‐PENGs and US‐TENGs) for advantageous applications. This review article first summarizes the fundamentals, classification, and design engineering of UMMs after introducing ultrasound energy for WET technology. In addition to addressing using UMMs, the topical progress of innovative UMMs in US‐ETs is conceptually presented. Moreover, the advanced approaches of metamaterials are reported in the categorized applications of US‐PENGs and US‐TENGs. Finally, some current perspectives and encounters of UMMs in US‐ETs are offered. With this objective in mind, this review explores the potential revolution of reliable integrated energy transfer systems through the transformation of metamaterials into ultrasound‐driven active mediums for generators. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging.

Author

Yue, Renye, Li, Zhe, Liu, Huiyi, Wang, Youjuan, Li, Yuhang, Yin, Rui, Yin, Baoli, Qian, Haisheng, Kang, Heemin, Zhang, Xiaobing, and Song, Guosheng

Subjects
COMPANION diagnostics, MAGNETIC resonance imaging, RADIATION doses, DOSE-response relationship (Radiation), RADIOTHERAPY, CONTRAST-enhanced magnetic resonance imaging, CONTRAST media
Abstract

Companion diagnostics using biomarkers have gained prominence in guiding radiotherapy. However, biopsy-based techniques fail to account for real-time variations in target response and tumor heterogeneity. Herein, we design an activated afterglow/MRI probe as a companion diagnostics tool for dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy in vivo. We employ ultrabright afterglow nanoparticles and ultrasmall FeMnOx nanoparticles as dual contrast agents, significantly broadening signal change range and enhancing the sensitivity of APE1 imaging (limit of detection: 0.0092 U/mL in afterglow imaging and 0.16 U/mL in MRI). We devise longitudinally and transversely subtraction-enhanced imaging (L&T-SEI) strategy to markedly enhance MRI contrast and signal-to-noise ratio between tumor and normal tissue of living female mice. The combined afterglow and MRI facilitate both anatomical and functional imaging of APE1 activity. This probe enables correlation of afterglow and MRI signals with APE1 expression, radiation dosage, intratumor ROS, and DNA damage, enabling early prediction of radiotherapy outcomes (as early as 3 h), significantly preceding tumor size reduction (6 days). By monitoring APE1 levels, this probe allows for early and sensitive detection of liver organ injury, outperforming histopathological analysis. Furthermore, MRI evaluates APE1 expression in radiation-induced abscopal effects provides insights into underlying mechanisms, and supports the development of treatment protocols. Companion diagnostics using biomarkers are promising for guiding radiotherapy, but biopsy-based techniques normally fail to detect real-time variations in target response and tumor heterogeneity. Herein, the authors report an activated afterglow/MRI probe as a companion diagnostics tool for dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy in vivo. [ABSTRACT FROM AUTHOR]

Published
2024
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41. The interplay of oxytocin and sex hormones

Author

Quintana, Daniel S, primary, Glaser, Bernt Damian, additional, Kang, Heemin, additional, Kildal, Emilie Smith-Meyer, additional, Audunsdottir, Kristin, additional, Sartorius, Alina M., additional, and barth, claudia, additional

Published
2024
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42. 3D Assembly of Cryo(Bio)Printed Modular Units for Shelf‐Ready Scalable Tissue Fabrication (Adv. Funct. Mater. 4/2024)

Author

Luo, Zeyu, primary, Lian, Liming, additional, Stocco, Thiago, additional, Guo, Jie, additional, Mei, Xuan, additional, Cai, Ling, additional, Andrabi, Syed Muntazir, additional, Su, Yajuan, additional, Tang, Guosheng, additional, Ravanbakhsh, Hossein, additional, Li, Wanlu, additional, Wang, Mian, additional, Kuang, Xiao, additional, Garciamendez‐Mijares, Carlos Ezio, additional, Wang, Di, additional, Wang, Zongliang, additional, Liao, Junlong, additional, Xie, Maobin, additional, Xie, Jingwei, additional, Kang, Heemin, additional, Lobo, Anderson Oliveira, additional, Zhou, Zongke, additional, and Zhang, Yu Shrike, additional

Published
2024
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43. Magnetically-responsive silica–gold nanobowls for targeted delivery and SERS-based sensing

Author

Mo, Alexander H, Landon, Preston B, Gomez, Karla Santacruz, Kang, Heemin, Lee, Joon, Zhang, Chen, Janetanakit, Woraphong, Sant, Vrinda, Lu, Tianyu, Colburn, David A, Akkiraju, Siddhartha, Dossou, Samuel, Cao, Yue, Lee, Kuo-Fen, Varghese, Shyni, Glinsky, Gennadi, and Lal, Ratnesh

Subjects
Physical Sciences, Engineering, Nanotechnology, Biomedical Engineering, Bioengineering, Cell Line, Tumor, Gold, Humans, Nanoparticles, Polystyrenes, Silicon Dioxide, Spectrum Analysis, Raman, Chemical Sciences, Technology, Nanoscience & Nanotechnology, Chemical sciences, Physical sciences
Abstract

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

Published
2016

45. 3D Assembly of Cryo(Bio)Printed Modular Units for Shelf‐Ready Scalable Tissue Fabrication

Author

Luo, Zeyu, primary, Lian, Liming, additional, Stocco, Thiago, additional, Guo, Jie, additional, Mei, Xuan, additional, Cai, Ling, additional, Andrabi, Syed Muntazir, additional, Su, Yajuan, additional, Tang, Guosheng, additional, Ravanbakhsh, Hossein, additional, Li, Wanlu, additional, Wang, Mian, additional, Kuang, Xiao, additional, Garciamendez‐Mijares, Carlos Ezio, additional, Wang, Di, additional, Wang, Zongliang, additional, Liao, Junlong, additional, Xie, Maobin, additional, Xie, Jingwei, additional, Kang, Heemin, additional, Lobo, Anderson Oliveira, additional, Zhou, Zongke, additional, and Zhang, Yu Shrike, additional

Published
2023
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46. The effects of oxytocin administration on social and routinized behaviors in autism: A preregistered systematic review and meta-analysis

Author

Audunsdottir, Kristin, primary, Sartorius, Alina M., additional, Kang, Heemin, additional, Glaser, Bernt Damian, additional, Boen, Rune, additional, Nærland, Terje, additional, Alaerts, Kaat, additional, Kildal, Emilie Smith-Meyer, additional, Westlye, Lars T., additional, Andreassen, Ole A., additional, and Quintana, Daniel S, additional

Published
2023
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48. Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment

Author

Shih, Yu-Ru, Phadke, Ameya, Yamaguchi, Tomonori, Kang, Heemin, Inoue, Nozomu, Masuda, Koichi, and Varghese, Shyni

Subjects
Engineering, Biomedical Engineering, Stem Cell Research - Nonembryonic - Non-Human, Biotechnology, Bioengineering, Regenerative Medicine, Stem Cell Research, Development of treatments and therapeutic interventions, Underpinning research, 5.2 Cellular and gene therapies, 1.3 Chemical and physical sciences, Musculoskeletal, Animals, Biomimetic Materials, Bone Development, Bone Matrix, Bone Substitutes, Bone Transplantation, Calcium Phosphates, Equipment Design, Equipment Failure Analysis, Femoral Fractures, Male, Materials Testing, Osteogenesis, Rats, Rats, Nude, Tissue Scaffolds, Biomimetic materials, Bone grafts, Posterolateral fusion, Spine, Biomineralization
Abstract

Advances in tissue engineering have offered new opportunities to restore anatomically and functionally compromised tissues. Although traditional tissue engineering approaches that utilize biomaterials and cells to create tissue constructs for implantation or biomaterials as a scaffold to deliver cells are promising, strategies that can activate endogenous cells to promote tissue repair are more clinically attractive. Here, we demonstrate that an engineered injectable matrix mimicking a calcium phosphate (CaP)-rich bone-specific microenvironment can recruit endogenous cells to form bone tissues in vivo. Comparison of matrix alone with that of bone marrow-soaked or bFGF-soaked matrix demonstrates similar extent of neo-bone formation and bridging of decorticated transverse processes in a posterolateral lumbar fusion rat model. Synthetic biomaterials that stimulate endogenous cells without the need for biologics to assist tissue repair could circumvent limitations associated with conventional tissue engineering approaches, including ex vivo cell processing and laborious efforts, thereby accelerating the translational aspects of regenerative medicine.

Published
2015

49. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling.

Author

Shih, Yu-Ru, Hwang, YongSung, Phadke, Ameya, Kang, Heemin, Hwang, Nathaniel, Caro, Eduardo, Nguyen, Steven, Siu, Michael, Lee, Oscar, Varghese, Shyni, Gianneschi, Nathan, Chien, Shu, Theodorakis, Emmanuel, and Vecchio, Kenneth

Subjects
biomimetic material, bone metabolism, mineralized matrix, phosphate signaling, Adenosine, Adenosine Triphosphate, Biocompatible Materials, Bone and Bones, Calcium Phosphates, Cell Differentiation, Cells, Cultured, Chromatography, High Pressure Liquid, Gene Expression Regulation, Homeostasis, Humans, Mesenchymal Stem Cells, Osteogenesis, Phenotype, Phosphates, RNA, Small Interfering, Receptor, Adenosine A2B, Regeneration, Signal Transduction, Sodium-Phosphate Cotransporter Proteins, Type III, Stem Cells
Abstract

Synthetic matrices emulating the physicochemical properties of tissue-specific ECMs are being developed at a rapid pace to regulate stem cell fate. Biomaterials containing calcium phosphate (CaP) moieties have been shown to support osteogenic differentiation of stem and progenitor cells and bone tissue formation. By using a mineralized synthetic matrix mimicking a CaP-rich bone microenvironment, we examine a molecular mechanism through which CaP minerals induce osteogenesis of human mesenchymal stem cells with an emphasis on phosphate metabolism. Our studies show that extracellular phosphate uptake through solute carrier family 20 (phosphate transporter), member 1 (SLC20a1) supports osteogenic differentiation of human mesenchymal stem cells via adenosine, an ATP metabolite, which acts as an autocrine/paracrine signaling molecule through A2b adenosine receptor. Perturbation of SLC20a1 abrogates osteogenic differentiation by decreasing intramitochondrial phosphate and ATP synthesis. Collectively, this study offers the demonstration of a previously unknown mechanism for the beneficial role of CaP biomaterials in bone repair and the role of phosphate ions in bone physiology and regeneration. These findings also begin to shed light on the role of ATP metabolism in bone homeostasis, which may be exploited to treat bone metabolic diseases.

Published
2014

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