219 results on '"Kanekura, Kohsuke"'
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2. How can we interpret the relationship between liquid-liquid phase separation and amyotrophic lateral sclerosis?
3. Spatially heterogeneous dynamics of droplets formed by arginine-rich dipeptides and poly-A RNA during liquid-liquid phase separation.
4. Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity
5. Establishment of chemically oligomerizable TAR DNA-binding protein-43 which mimics amyotrophic lateral sclerosis pathology in mammalian cells
6. Neuroplastin Modulates Anti-inflammatory Effects of MANF
7. Analysis of Carcinogenic Involvement of MicroRNA Pattern in Peripheral Non-Cancerous Tissues and Chronic Viral Liver Injury.
8. A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome
9. miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy
10. Poor outcomes in carriers of the RNF213 variant (p.Arg4810Lys) with pulmonary arterial hypertension
11. Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
12. Therapeutic potential of PLK1 inhibition in triple-negative breast cancer
13. Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells.
14. Comprehensive analysis of liver and blood miRNA in precancerous conditions
15. miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy
16. Mechanism of mitochondrial translation inhibition by C9ORF72 dipeptide repeat proteins.
17. 筋萎縮性側索硬化症(ALS)原因ジペプチドリピートの細胞内局在および毒性メカニズムの解明
18. Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells
19. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome
20. Role of ER Stress in Dysfunction of the Nervous System
21. Characterization of membrane penetration and cytotoxicity of C9orf72-encoding arginine-rich dipeptides
22. The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein
23. Effect of Multivalency on Phase-Separated Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA at the Solid/Liquid Interface
24. Order controls disordered droplets: structure-function relationships in C9ORF72-derived poly(PR)
25. Chemically oligomerizable TDP-43: a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis
26. An improved macromolecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under stressed conditions
27. MicroRNA and gynecologic cancers
28. Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine
29. Research Resource: Monitoring Endoplasmic Reticulum Membrane Integrity in β-Cells at the Single-Cell Level
30. Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration
31. Calcium Efflux From the Endoplasmic Reticulum Leads to β-Cell Death
32. ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis
33. Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis
34. Diffusion of LLPS Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA on Chemically Modified Glass Surface
35. An improved molecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under pathological conditions
36. A Novel Homozygous Mutation of Thyroid Peroxidase Gene Abolishes a Disulfide Bond Leading to Congenital Hypothyroidism
37. Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice
38. Neuroplastin Modulates Anti-Inflammatory Effects of MANF
39. Alternate Structure Controls For Phase Separation and Toxicity of Poly(PR) C9ORF72 Dipeptide
40. ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB
41. A Rac1/Phosphatidylinositol 3-Kinase/Akt3 Anti-apoptotic Pathway, Triggered by AlsinLF, the Product of the ALS2 Gene, Antagonizes Cu/Zn-superoxide Dismutase (SOD1) Mutant-induced Motoneuronal Cell Death
42. Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin
43. Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimerʼs disease-related neurotoxicity: functional potentiation by isomerization and dimerization
44. Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death
45. 10. Dantrolene as a Therapeutic Option for Wolfram Syndrome (134-OR)
46. 345-LB: Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF): A New Therapeutic Target for Wolfram Syndrome
47. Genomic Comparison With Supercentenarians Identifies RNF213 as a Risk Gene for Pulmonary Arterial Hypertension
48. SOX17 Mutations in Japanese Patients with Pulmonary Arterial Hypertension
49. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death
50. Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation
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