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852 results on '"Kaneko, Hidehiro"'

22. Association Between Early Initiation of Cardiac Rehabilitation and Short-Term Outcomes of Patients With Acute Heart Failure Admitted to the Intensive Care Unit

Author

Ishibashi, Takuma, Kaneko, Hidehiro, Ueno, Kensuke, Morita, Kojiro, Itoh, Hidetaka, Okada, Akira, Kamiya, Kentaro, Suzuki, Yuta, Matsuoka, Satoshi, Fujiu, Katsuhito, Michihata, Nobuaki, Jo, Taisuke, Takeda, Norifumi, Morita, Hiroyuki, Ako, Junya, Node, Koichi, Yasunaga, Hideo, and Komuro, Issei

Published
2023
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33. Dose‐dependent association between estimated glomerular filtration rate and the subsequent risk of depression: An analysis of a nationwide epidemiological dataset.

Author

Ko, Toshiyuki, Kaneko, Hidehiro, Suzuki, Yuta, Okada, Akira, Azegami, Tatsuhiko, Fujiu, Katsuhito, Takeda, Norifumi, Morita, Hiroyuki, Yokoo, Takashi, Hayashi, Kaori, Komuro, Issei, Yasunaga, Hideo, Nangaku, Masaomi, and Takeda, Norihiko

Subjects
*EPIDEMIOLOGY, *GLOMERULAR filtration rate, *KIDNEY physiology, *EPIDERMAL growth factor receptors, *REGRESSION analysis
Abstract

Background: Although the risk of depression is well‐known in the patients with kidney dysfunction, especially at the late stages, little is known about the exact point at which the decline in estimated glomerular filtration rate (eGFR) begins to significantly increase the risk of depression. In the present study, we analysed a nationwide epidemiological dataset to investigate the dose‐dependent association between baseline eGFR and a future risk of developing depression in a general population. Methods: We retrospectively analysed 1,518,885 individuals (male: 46.3%) without a history of depression identified between April 2014 and November 2022 within a nationwide epidemiological database, provided by DeSC Healthcare (Tokyo, Japan). We investigated the association of eGFR with the incidence of depression using Cox regression analyses and also conducted cubic spline analysis to investigate the dose‐dependent association between eGFR and depression. Results: In the mean follow‐up of 1218 ± 693 days, 45,878 cases (3.0% for total participants, 2.6% for men and 3.3% for women) of depression were recorded. The risk of depression increased with the eGFR decline as well as the presence of proteinuria. Multivariable Cox regression analysis showed the hazard ratio (95% CI) of depression in each kidney function category (eGFR ≥90, 60–89, 45–59, 30–44, 15–29, and < 15 mL/min/1.73 m2) was 1.14 (1.11–1.17), 1 (reference), 1.11 (1.08–1.14), 1.51 (1.43–1.59), 1.77 (1.57–1.99) and 1.77 (1.26–2.50), respectively. In the cubic spline analysis, the risk of depression continued to increase monotonically as the eGFR declined when the eGFR fell below approximately 65 mL/min/1.73 m2. Conclusions: Our analysis using a large‐scale epidemiological dataset presented the dose‐dependent association between eGFR decline and the risk of depression, which highlights the importance of incorporating mental health assessments into the routine care of patients with kidney dysfunction, regardless of the stage of their disease. [ABSTRACT FROM AUTHOR]

Published
2025
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34. Significance of eGFR and proteinuria for cardiovascular disease in individuals beyond 85 years of age.

Author

Azegami, Tatsuhiko, Kaneko, Hidehiro, Okada, Akira, Suzuki, Yuta, Fujiu, Katsuhito, Morita, Hiroyuki, Takeda, Norifumi, Takeda, Norihiko, Fukui, Akira, Yokoo, Takashi, Node, Koichi, Yasunaga, Hideo, Nangaku, Masaomi, and Hayashi, Kaori

Subjects
*OLDER people, *KIDNEY physiology, *GLOMERULAR filtration rate, *EPIDERMAL growth factor receptors, *CARDIOVASCULAR diseases
Abstract

Background There are limited data on how advancing age influences prediction of cardiovascular disease (CVD) risk based on the estimated glomerular filtration rate (eGFR) and proteinuria, especially in older adults, including those aged ≥85 years old. This study aimed to clarify the association of eGFR and proteinuria with CVD outcomes and the impact of age on this association. Methods The distribution of eGFR and urine protein in Japan was assessed retrospectively using real-world administrative claims and health checkup data collected between April 2014 and November 2022. We investigated the associations of these two parameters with the incidence of CVD, with an emphasis on the impact of aging. Results We assessed 1 829 020 individuals for distribution of eGFR and proteinuria; after excluding those with known CVD, their association with CVD risk was examined in 1 040 101 individuals aged ≥40 years. The prevalence of impaired kidney function (eGFR <60 mL/min/1.73 m2) increased with age, being 0.7%, 9.2%, 21.9%, 40.2% and 60.2% at the ages of 18–39, 40–64, 65–74, 75–84 and ≥85 years, respectively (P for trend <.001); similarly, the proportion with positive proteinuria increased with age, being 2.7%, 4.3%, 5.6%, 9.2% and 15.8%, respectively (P for trend <.001). Both eGFR and urine protein were identified to be independent risk factors for CVD. Hazard ratios for CVD increased significantly when eGFR was <45 mL/min/1.73 m2 at the ages of 40–64, 65–74 and 75–84 years and <30 mL/min/1.73 m2 at ≥85 years, while proteinuria remained significantly associated with a high CVD risk regardless of age. These findings were consistent even when analyzed separately by sex. Conclusions This study identified eGFR and urine dipstick proteinuria to be independent risk factors for CVD, even among individuals aged ≥85 years. However, the contribution of eGFR to the CVD risk was attenuated by aging, whereas proteinuria remained less affected by advancing age. [ABSTRACT FROM AUTHOR]

Published
2025
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35. The Benefits of Early Rehabilitation for Patients With Acute Heart Failure Requiring IV Inotropic Drugs.

Author

Ueno, Kensuke, Kaneko, Hidehiro, Kamiya, Kentaro, Okada, Akira, Konishi, Masaaki, Imamura, Teruhiko, Suzuki, Yuta, Fujiu, Katsuhito, Takeda, Norifumi, Morita, Hiroyuki, Ako, Junya, Node, Koichi, Yasunaga, Hideo, Takeda, Norihiko, and Komuro, Issei

Abstract

OBJECTIVES: The benefits of early rehabilitation for patients with acute heart failure (HF) requiring IV inotropic drugs have yet to be determined. We investigated the association between early rehabilitation and short-term clinical outcomes in patients with acute HF requiring IV inotropic drugs. DESIGN: Retrospective cohort study. SETTING: This study used data including more than 90% of patients at a tertiary emergency hospital in Japan. PATIENTS: This study included patients with acute HF who required IV inotropic drugs within 2 days of admission. INTERVENTIONS: We compared patients who commenced rehabilitation within 2 days of admission (the early rehabilitation group) and those who did not (the control group). MEASUREMENTS AND MAIN RESULTS: Propensity score matching was used to compare in-hospital mortality, 30-day all-cause and HF readmissions, length of stay, and Barthel Index (BI) at discharge between patients who received early rehabilitation and those who did not. Totally, 38,302 patients were eligible for inclusion; of these, 5,127 received early rehabilitation and 5,126 pairs were generated by propensity score matching. After propensity score matching, the patients who received early rehabilitation had a lower in-hospital mortality rate than those who did not (9.9% vs. 13.2%; p < 0.001). The relative risk (95% CI) of early rehabilitation for in-hospital mortality was 0.75 (0.67–0.83). Patients undergoing early rehabilitation exhibited a shorter mean length of stay (25.5 vs. 27.1; p < 0.001), lower 30-day all-cause (14.1% vs. 16.4%; p = 0.001) and HF (8.6% vs. 10.4%; p = 0.002) readmissions, and higher BI scores at discharge (68 vs. 67; p = 0.096). Consistent findings were observed across subgroups, including in patients 80 years old or older, those with a body mass index less than 18.5 kg/m2, and those with BI scores less than 60. CONCLUSIONS: The early prescription of rehabilitation was associated with favorable short-term outcomes even for patients with acute HF requiring IV inotropic drugs. [ABSTRACT FROM AUTHOR]

Published
2025
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36. Current Status and Future Perspective of Onco-Hypertension.

Author

Azegami, Tatsuhiko, Kaneko, Hidehiro, Minegishi, Shintaro, Suzuki, Yuta, Morita, Hiroyuki, Fujiu, Katsuhito, Takeda, Norihiko, Yokoo, Takashi, Yano, Yuichiro, Hayashi, Kaori, Nishiyama, Akira, and Node, Koichi

Subjects
BLOOD pressure, CANCER survivors, POPULATION aging, CARDIOVASCULAR diseases, HYPERTENSION
Abstract

Background Hypertension and cancer are both increasing with age. Recently, the new concept of "Onco-Hypertension" has been proposed to address the mutual risks posed by hypertension and cancer and to provide comprehensive care for patients with these two conditions in an aging society. Methods In this review, we provide an overview of the current status and future perspective of the "Onco-Hypertension," including our research findings. Results Hypertension and cancer share common risk factors and may be interrelated in pathogenesis: Hypertension is involved in the development of certain cancers, and cancer survivors have a higher incidence of hypertension. With recent advances in cancer therapy, the number of cancer survivors has increased. Cancer survivors not only have a higher risk of incident hypertension but also an increased risk of future cardiovascular events, highlighting the growing importance of comprehensive care. Conclusions There exists a diverse array of epidemiological and pathophysiological relationships between hypertension and cancer. It is imperative to move the emerging scientific field of "Onco-Hypertension" forward through relentless research efforts. [ABSTRACT FROM AUTHOR]

Published
2025
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37. Association of retinal atherosclerosis assessed using Keith-Wagener-Barker system with incident heart failure and other atherosclerotic cardiovascular disease: Analysis of 319,501 individuals from the general population

Author

Matsuoka, Satoshi, Kaneko, Hidehiro, Okada, Akira, Itoh, Hidetaka, Suzuki, Yuta, Fujiu, Katsuhito, Michihata, Nobuaki, Jo, Taisuke, Takeda, Norifumi, Morita, Hiroyuki, Nakamura, Sunao, Node, Koichi, Yasunaga, Hideo, and Komuro, Issei

Published
2022
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38. Risk for Proteinuria in Newly Defined Hypertensive People Based on the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline

Author

Suzuki, Yuta, Kaneko, Hidehiro, Okada, Akira, Itoh, Hidetaka, Fujiu, Katsuhito, Michihata, Nobuaki, Jo, Taisuke, Takeda, Norifumi, Morita, Hiroyuki, Yamaguchi, Satoko, Yano, Yuichiro, Kamiya, Kentaro, Matsunaga, Atsuhiko, Ako, Junya, Fukui, Akira, Yokoo, Takashi, Nishiyama, Akira, Node, Koichi, Yamauchi, Toshimasa, Nangaku, Masaomi, Yasunaga, Hideo, and Komuro, Issei

Published
2022
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42. Significance of eGFR and proteinuria for cardiovascular disease in individuals beyond 85 years

Author

Azegami, Tatsuhiko, primary, Kaneko, Hidehiro, additional, Okada, Akira, additional, Suzuki, Yuta, additional, Fujiu, Katsuhito, additional, Morita, Hiroyuki, additional, Takeda, Norifumi, additional, Takeda, Norihiko, additional, Fukui, Akira, additional, Yokoo, Takashi, additional, Node, Koichi, additional, Yasunaga, Hideo, additional, Nangaku, Masaomi, additional, and Hayashi, Kaori, additional

Published
2024
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