136 results on '"Kane AD"'
Search Results
2. Detection and response to acute systemic hypoxia
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Kane Ad, Giussani Da, Kothmann E, Giussani, Dino [0000-0002-1308-1204], and Apollo - University of Cambridge Repository
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Anesthesiology and Pain Medicine ,Text mining ,business.industry ,Systemic hypoxia ,Medicine ,32 Biomedical and Clinical Sciences ,business ,Bioinformatics ,3202 Clinical Sciences ,Article - Published
- 2023
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3. Epidemiological Aspects of Acute Coronary Syndromes in Saint-Louis, Senegal
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K.R, Diop, primary, Niasse A, Ndao I, additional, S.M, Beye, additional, J.S, Mingou, additional, Y, Diouf, additional, P.G, Ndiaye, additional, C.M.B, Diop, additional, C.A.B, Samb, additional, M.T, Diouf, additional, F, Aw, additional, S.A, Sarr, additional, M, Bodian, additional, M.B, Ndiaye, additional, Kane, Ad, additional, M, Diao, additional, and A, Kane, additional
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- 2022
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4. Les manifestations cardio-vasculaires au cours du lupus érythémateux systémique à Dakar : étude descriptive à propos de 50 cas
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Ngaïdé, A.A., Ly, F., Ly, K., Diao, M, Kane, Ad., Mbaye, A., Lèye, M., Aw, F., Sarr, S.A., Dioum, M., Ndao, C.T, Gaye, N.D., Ndiaye, M.B., Bodian, M., Bah, M.B., Ndiaye, M., Cissé, A.F., Kouamé, I., Tabane, A., Mingou, J.S., Thiombiano, P., Kane, A., and Bâ, S.A.
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- 2016
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- View/download PDF
5. Prévalence et facteurs liés à l’observance thérapeutique chez des patients noirs africains coronariens stables, suivis en ambulatoire en service de cardiologie de Dakar au Sénégal
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Mbaye, A., Koukaba Ntontolo, F.L., Diomou, A.F., Bodian, M., Ndiaye, M.B., Kane, Ad., Yaméogo, N.V., Pessinaba, S., Sarr, S.A., Dioum, M., Thiam, A., Hakim, R., Diao, M., and Kane, A.
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- 2013
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6. Une forme familiale de la non-compaction ventriculaire chez une mère et deux de ses fils à Saint-Louis du Sénégal
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Pessinaba, S., Mbaye, A., Yabéta, G.A.D., Ndiaye, M.B., Kane, Ad., Harouna, H., Bodian, M., Mathieu, S.J.B., Diack, B., Diao, M., and Kane, A.
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- 2013
- Full Text
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7. Dépistage de l’artériopathie oblitérante asymptomatique des membres inférieurs par la mesure de l’index de pression systolique dans la population générale de Saint-Louis (Sénégal)
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Pessinaba, S., Mbaye, A., Kane, Ad., Guene, B.D., Mbaye Ndour, M., Niang, K., Jobe, M., Cazaubon, M., Mathieu, J.-B.S., Kane, M., Sow, D. Diagne, Diack, B., and Kane, A.
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- 2012
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8. Vascular complications of infective endocarditis
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Pessinaba, S., Kane, Ad., Ndiaye, M.B., Mbaye, A., Bodian, M., Dia, M.M., Sarr, S.A., Diao, M., Sarr, M., Kane, A., and Ba, S.A.
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- 2012
- Full Text
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9. Left Atrium Myxoma Revealed by an Ischemic Stroke: About a Case
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Tabane A, Sarr Sa, Beye Sm, Rissonga Mk, Diouf Y, Kane Ad, Ndichout A, K. Diop, and Fatou Aw
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medicine.medical_specialty ,business.industry ,Left atrium ,Myxoma ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Benign tumor ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Embolism ,Internal medicine ,Ischemic stroke ,cardiovascular system ,Etiology ,medicine ,Cardiology ,cardiovascular diseases ,030212 general & internal medicine ,Left Atrial Myxoma ,Complication ,business - Abstract
Introduction: Left atrial myxoma is a rare benign tumor. It can be an embolic complication such as an ischemic stroke. Case presentation: It was a 48 years old patient who was referred to our unity for the etiological investigation of an ischemic stroke. She did not have personal medical and surgical history. She had a recent right hemiplegia. The cardiac auscultation found a mitral diastolic murmur. The brain CT showed a recent ischemic stroke in the superficial and deep left sylvian territory. The transthoracic echography revealed a myxomatous mass, responsible of an obstacle of the left ventricular filling. Anticoagulation by antivitamin K (AVK) had been initiated and a resection of the mass indicated. Conclusions: The left atrial myxoma is a rare benign tumor whose mode of revelation can be an embolic complication. The Echocardiography is reference imaging modality in diagnosis with a high sensitivity.
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- 2019
10. Spontaneous Occlusion of the Sinus Node Artery: A Case Report
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Diop KR, Mingou JS, Beye SM, Ndiaye PG, Diop CMBM, Diouf Y, Diallo SD, Akanni S, Sarr SA, Fatou AW, Bodian M, Ndiaye MB, Kane AD, Diao M, and Kane A
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General Environmental Science - Abstract
Introduction: Occlusion of the sinus node artery is a rare situation. It is responsible for sinus node dysfunction and often occurs accidentally during percutaneous coronary intervention of a proximal lesion of the right coronary artery Case Report: This is a sixty-year-old woman with high blood pressure treat by dual therapy (an enzyme conversion inhibitor and a thiazide diuretic), who presented to the cardiological emergency room for a typical angina pain that had been evolving for 48 hours without a lull. Her clinical examination was normal apart from grade 3 arterial hypertension. The 18-lead surface electrocardiogram showed an electrical left ventricular hypertrophy with undershift of the ST segment in lateral and posterior territories, with an overshift of the ST segment in the antero-septal without any sign of necrosis. Biologically, the ultra-sensitive troponinemia was 88 times normal. The diagnosis of NSTEMI with troponin was retained with an intermediate ischaemic risk. Transthoracic Doppler echocardiography showed concentric hypertrophy of the left ventricular walls and dyskinesia of the right ventricle infero-apical wall. The coronary angiography showed an occlusion of the sinus node artery and a left coronary artery atheromatous with an intermediate lesion in the middle segment of the anterior interventricular artery. Conclusion: The present clinical case highlights the diversity in the expression of a sinus node artery occlusion that can occur spontaneously outside of a percutaneous coronary intervention.
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- 2021
11. Thrombose veineuse et occlusion artérielle bilatérale des membres inférieurs révélant une infection par le VIH
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Pessinaba, S., Bodian, M., Kane, Ad., Sarr, A. W., Ndiaye, M. B., Kafando, H., Mbaye, A., Diao, M., Sarr, M., Kane, A., and Ba, S. A.
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- 2013
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12. Epidemiology of Sudden Cardiac Death: Necropsic Studies at Aristide Le Dantec Hospital
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Bodian M, Akanni SCG, Beye SM, Mingou JS, Diouf Y, Niass AD, Aw F, Sarr SA, Diop CMBM, Ndiaye PG, Ngaïdé AA, Dioum M, Lèye M, Ralaizandry U, Ndiaye MB, Mbaye A, Kane AD, Kane A, and Diao M
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General Environmental Science - Abstract
Introduction: Sudden cardiac death (SCD) remains a major public health issue. In Senegal, there is a lack of data on this phenomenon; this underlies the relevance of this study whose objective is to study the epidemiological profile of victims experiencing unrecovered sudden cardiac arrest at Aristide LE DANTEC Hospital. Patients and Methods: This is a transverse study with retrospective data collection from January 1, 2016 to January 31, 2017. Included, in the study were all victims of sudden cardiac death in Dakar who had a necropsy in the morgues of Aristide Le Dantec Hospital. Results: We recorded 69 cases of sudden death of cardiovascular origin from 169 forensic autopsy reports, or 40.8% of autopsies. The average age was 44 years with a male predominance in 76.81%. The large majority of death occurred at home (26%), without witnesses (48%) and at rest (36%). Two cases of sudden death, or 3%, occurred at exertion. These deaths were recorded in 16% of cases in the middle of the day. The highest death rate was recorded during the month of December (15.9%). Malaise was the predominant symptom (13%) followed by emotional stress (6%). The existence of a history could only be clarified in 4% of cases. The electrocardiogram was only performed in 1 case. At necropsy, ischemic heart disease was the leading disease (46%), 26% of which was due to myocardial infarction, followed by hypertrophic cardiomyopathy (16%) and mixed cardiomyopathy (13%). Tamponade, dilated cardiomyopathy and aortic dissection were found in 9%, 6% and 4% of cases, respectively. Conclusion: Sudden cardiac death is a major public health problem. In the Senegalese population, victims of unrecovered SCD are relatively young with a predominance of men. Coronary artery disease is the most frequently implicated pathology. Faced with this observation, a national program for the integrated control of cardiovascular risk factors is necessary.
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- 2021
13. 'Diagnosis and Evaluation of Hypertension Control in Dakar: Role of Ambulatory Blood Pressure Measurement'
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M.M.M. Leye, Fatou Aw Leye, Bathily C Sarr Sa, Mohamed Lamine Diao, Ndiaye M Diop Cmbm, A. Mbaye, Joseph Salvador Mingou, Serigne Abdou Ba, Stéphanie Akanni, Papa Nguirane Ndiaye, A W Kane, Malick Bodian, D W Balde, M T Diouf, Affangla A, Momar Dioum, Kane Ad, Ngaide Aa, and Ndiaye Mb
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Blood pressure control ,medicine.medical_specialty ,Chronic disease ,Hypertension control ,White coat ,business.industry ,Public health ,Emergency medicine ,Ambulatory blood pressure measurement ,medicine ,General Earth and Planetary Sciences ,business ,General Environmental Science - Abstract
Hypertension is a common chronic disease representing a major public health problem. In 2000, it reached one out of four adults worldwide, ie a rate of 26.5%, with an evolution in prevalence
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- 2020
14. Evaluation of Thrombolysis in the Management of St-Elevation Myocardial Infarction (STEMI) in Isolated Cardiology Unit
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I Sangaré, Ba Sa, M. Doumbia, B Dembélé, Kane A, B Diallo, NGaide A, Kane Ad, Diao M, Menta I, Traoré Ak, Sylla Is, Sangaré Z, and Mamadou Ndiaye
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medicine.medical_specialty ,business.industry ,St elevation myocardial infarction ,Internal medicine ,medicine.medical_treatment ,medicine ,Cardiology ,Thrombolysis ,business ,General Environmental Science - Published
- 2017
15. Impact of the Covid-19 Pandemic on the Prolongation of the Management of Myocardial Infarctions Seen Late: A Cross-Sectional Study of 25 Cases Collected in the Cardiology Department of the Aristide Le Dantec Hospital in Dakar (Senegal)
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Mingou, J. S., primary, Akanni, S., additional, Diop, H. B., additional, Bodian, M., additional, Diop, K. R., additional, Sarr, S. A., additional, Aw, F., additional, Diop, C. M. B., additional, Ndiaye, P. G., additional, Diouf, Y., additional, Mbaye, A., additional, Kane, Ad, additional, Ndiaye, M. B., additional, Diao, M., additional, and Kane, A., additional
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- 2021
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16. Fetal in vivo continuous cardiovascular function during chronic hypoxia
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Allison, BJ, Brain, KL, Niu, Y, Kane, AD, Herrera, EA, Thakor, AS, Botting, KJ, Cross, CM, Itani, N, Skeffington, KL, Beck, C, Giussani, DA, Giussani, Dino [0000-0002-1308-1204], and Apollo - University of Cambridge Repository
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Sheep ,Maternal, Fetal and Neonatal Physiology ,Cardiovascular Physiology ,Fetal Hypoxia ,Fetal Heart ,Pregnancy ,Coronary Circulation ,embryonic structures ,Heart Function Tests ,Remote Sensing Technology ,Animals ,Female ,Placental Circulation ,Blood Gas Analysis ,Hypoxia ,Techniques for Physiology - Abstract
Key points The in vivo fetal cardiovascular defence to chronic hypoxia has remained by and large an enigma because no technology has been available to induce significant and prolonged fetal hypoxia whilst recording longitudinal changes in fetal regional blood flow as the hypoxic pregnancy is developing.We introduce a new technique able to maintain chronically instrumented maternal and fetal sheep preparations under isobaric chronic hypoxia for most of gestation, beyond levels that can be achieved by high altitude and of relevance in magnitude to the human intrauterine growth‐restricted fetus.This technology permits wireless recording in free‐moving animals of longitudinal maternal and fetal cardiovascular function, including beat‐to‐beat alterations in pressure and blood flow signals in regional circulations.The relevance and utility of the technique is presented by testing the hypotheses that the fetal circulatory brain sparing response persists during chronic fetal hypoxia and that an increase in reactive oxygen species in the fetal circulation is an involved mechanism. Abstract Although the fetal cardiovascular defence to acute hypoxia and the physiology underlying it have been established for decades, how the fetal cardiovascular system responds to chronic hypoxia has been comparatively understudied. We designed and created isobaric hypoxic chambers able to maintain pregnant sheep for prolonged periods of gestation under controlled significant (10% O2) hypoxia, yielding fetal mean PaO2 levels (11.5 ± 0.6 mmHg) similar to those measured in human fetuses of hypoxic pregnancy. We also created a wireless data acquisition system able to record fetal blood flow signals in addition to fetal blood pressure and heart rate from free moving ewes as the hypoxic pregnancy is developing. We determined in vivo longitudinal changes in fetal cardiovascular function including parallel measurement of fetal carotid and femoral blood flow and oxygen and glucose delivery during the last third of gestation. The ratio of oxygen (from 2.7 ± 0.2 to 3.8 ± 0.8; P, Key points The in vivo fetal cardiovascular defence to chronic hypoxia has remained by and large an enigma because no technology has been available to induce significant and prolonged fetal hypoxia whilst recording longitudinal changes in fetal regional blood flow as the hypoxic pregnancy is developing.We introduce a new technique able to maintain chronically instrumented maternal and fetal sheep preparations under isobaric chronic hypoxia for most of gestation, beyond levels that can be achieved by high altitude and of relevance in magnitude to the human intrauterine growth‐restricted fetus.This technology permits wireless recording in free‐moving animals of longitudinal maternal and fetal cardiovascular function, including beat‐to‐beat alterations in pressure and blood flow signals in regional circulations.The relevance and utility of the technique is presented by testing the hypotheses that the fetal circulatory brain sparing response persists during chronic fetal hypoxia and that an increase in reactive oxygen species in the fetal circulation is an involved mechanism.
- Published
- 2016
17. Comparison of Single Culture and the Consortium of Growth-Promoting Rhizobacteria from Three Tomato (Lycopersicon esculentum Mill) Varieties
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Serigne Abdou Ba, Aw F, M.M.M. Leye, Sanghare Z, Adama Kane, Momar Dioum, Akonde Fatou Binetou, Sow A, Kane Ad, Aliou Alassane Ngaïdé, Maboury Diao, Simon Antoine Sarr, Malick Bodian, Kaya M, A. Mbaye, and Dieng Pa
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Tachycardia ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,medicine.diagnostic_test ,business.industry ,Urinary system ,Cardiomyopathy ,Atrial fibrillation ,medicine.disease ,Pheochromocytoma ,Junctional tachycardia ,Paraganglioma ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,medicine.symptom ,business ,Electrocardiography - Abstract
Pheochromocytoma may be responsible for various cardiac events including cardiac arrhythmias Authors report the case of a young child in whom pheochromocytoma was revealed by a junctional tachycardia The determination of urinary free catecholamines found a very high level of Noradrenaline and the abdominal CT showed a left hilar renal mass
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- 2017
18. Right Ventricular Infarction: Prevalence, Diagnostic and Therapeutic Characteristics, and Prognosis about 10 Cases
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Babaka S, Momar Dioum, Moctar Ma, Ndiaye Mb, Beye Sm, Serigne Abdou Ba, Ka MaM, Simon Antoine Sarr, El Azizi Ab, Maboury Diao, Adama Kane, Bah Mb, M. Ndiaye, Alassane Mbaye, Kane Ad, Aw F, Tabane A, Joseph Salvador Mingou, Malick Bodian, Aliou Alassane Ngaïdé, M.M.M. Leye, Sangaré Z, and Gaye Nd
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Right ventricular infarction ,Retrospective cohort study ,General Medicine ,Thrombolysis ,Single Center ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Ventricle ,Angioplasty ,Heart failure ,cardiovascular system ,medicine ,cardiovascular diseases ,Myocardial infarction ,business - Abstract
Objectives: The objectives of this study were to evaluate the prevalence of the right ventricular infarction and its diagnostic, therapeutic and prognostic characteristics. Patients and methods: A single center retrospective study was carried out between January 2011 and December 2014. Patients who were diagnosed with right ventricular infarction at electrocardiogram and echocardiography were recruited. Outcomes: Among the 159 patients hospitalized for myocardial infarction, 10 had myocardial infarction extended to the right ventricle (6.3%). It occurred on an inferior infarction in 7 cases out of 35 and anterior infarction in 3 cases out of 124. The mean age was 53 years and sex ratio M/F of 2.33. All patients had at least 3 cardiovascular risk factors. Right-sided heart failure was found in 4 patients. Right ventricular infaction was associated with inferior STEMI in 7 patients, and anterior STEMI in 3 patients. Echocardiography showed right ventricular dilatation and impaired right ventricular systolic function in respectively 6 cases. Thrombolysis was performed in 7 patients and rescue angioplasty in 1 case. A regressive cardiogenic collapse was noted in 6 cases and one death in 1 case. Conclusion: Right ventricular infarction is relatively rare and usually related to an extension of an inferior myocardial infarction. Hemodynamic instability is of worse prognosis.
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- 2017
19. Kent pathway catheter ablation about 18 cases: Results from a five-day camp between a Senegalese and South African team
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S.A. Ba, Tabane A, Y. Diouf, Fatou Aw, Ngaide Aa, Z. Sangare, Malick Bodian, A. Kane, Kane Ad, Maboury Diao, Beye Sm, A. Mbaye, R. Gopal, and Simon Antoine Sarr
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Radical treatment ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Mean age ,Physical examination ,Catheter ablation ,Application time ,Surgery ,Refractory ,Palpitations ,Medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Atrial tachycardia - Abstract
Objective To evaluate the South-South collaboration experience on Kent pathway catheter ablation. Patients and methods A cross-sectional, descriptive study of all patients who underwent catheter ablation of a Kent pathway during the five (5) day camp between a Senegalese and South African team. Results Eighteen patients were included, male-dominated (72.2%) with a mean age of 31 years. Patients had palpitations (100%) and a physical examination. The electrocardiogram recorded a pre-excitation (100%), a right postero-septal location (33%). Electrophysiologic exploration showed different pathways location: right (39%), parahiseal (28%), and left (22%) posterior septal, elective antegrade elective refractory (89%), atrial tachycardia (61%), and rhythmic risk (78%). Catheter ablation was performed in 83% of patients: transseptal puncture (22%), average number of radiofrequency shots of 3, application time of 60 seconds, average pre-excitation loss time of 7.5 seconds. The evolution at 1 month was favorable (94.4%). One (1) case of recurrence in a patient with multiple accessory pathways. There were no deaths or complications. Conclusion Catheter ablation, Kent pathway radical treatment possible and accessible in our countries.
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- 2019
20. Segmentation of Traumatic Brain Injuries with Convolutional Neural Networks
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Kamnitsas, K, Ledig, C, Newcombe, VFJ, Simpson, JP, Kane, AD, Menon, DK, Rueckert, D, and Glocker, B
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- 2015
21. Une tachycardie ventriculaire (TV) fasciculaire maligne dégénérant en fibrillation ventriculaire (FV) associée à un syndrome de repolarisation précoce
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Kane, Ad., Defaye, P., Jacon, P., Mbaye, A., and Machecourt, J.
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- 2012
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22. Paraplégie flasque révélant un adénome de Conn : à propos d’un cas
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Pessinaba, S., Mbaye, A., Yaméogo, N.V., Kane, Ad., Ndiaye, M.B., Diao, M., Bodian, M., Kane, M., Diagne, D., Fall, B., and Kane, A.
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- 2012
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23. Endocardite infectieuse aortopulmonaire d’évolution fatale : à propos d’un cas
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Ndiaye, M.B., Diao, M., Pessinaba, S., Kane, Ad., Mbaye, A., Bodian, M., Dia, M.M., Yaméogo, N.V., Sarr, M., Kane, A., and Ba, S.A.
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- 2012
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24. Thrombose veineuse et occlusion artérielle bilatérale des membres inférieurs révélant une infection par le VIH
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Pessinaba, S., primary, Bodian, M., additional, Kane, Ad., additional, Sarr, A. W., additional, Ndiaye, M. B., additional, Kafando, H., additional, Mbaye, A., additional, Diao, M., additional, Sarr, M., additional, Kane, A., additional, and Ba, S. A., additional
- Published
- 2012
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25. Faux-anévrysme du ventricule gauche chez un jeune Africain
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Ndiaye, M.-B., primary, Diao, M., additional, Bodian, M., additional, Kane, Ad., additional, Sarr, S.-A., additional, Mbaye, A., additional, Dia, M.-M., additional, Pessinaba, S., additional, Sarr, M., additional, Kane, A., additional, and Ba, S.-A., additional
- Published
- 2010
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26. Évolution et complications thromboemboliques de la myocardiopathie idiopathique du péripartum au CHU de Dakar : étude prospective à propos de 33 cas
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Kane, Ad., primary, Mbaye, M., additional, Ndiaye, M.B., additional, Diao, M., additional, Moreira, P.-M., additional, Mboup, C., additional, Diop, I.B., additional, Sarr, M., additional, Kane, A., additional, Moreau, J.-C., additional, and Ba, S.A., additional
- Published
- 2010
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27. La fibrillation atriale, fréquence, facteurs étiologiques, évolution et traitement dans un service de cardiologie de Dakar, Sénégal
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Kane Abdoul, Diao Maboury, Yameogo Nobila Valentin, Mbaye Alassane, Kane Adama, Mbaye Fatou, Ndiaye Mouhamadou Bamba, Bodian Malick, and Pessinaba Soulemane
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Arythmie cardiaque ,fibrillation atriale ,valvulopathie rhumatismale ,Senegal ,Medicine - Abstract
INTRODUCTION: La fibrillation atriale est le trouble du rythme cardiaque soutenu le plus fréquent. Les objectifs de ce travail étaient d’étudier la fréquence, les facteurs étiologiques, l’évolution et le traitement de la fibrillation atriale dans un service de cardiologie de Dakar au Sénégal. METHODES: Il s’agit d’une étude rétrospective réalisée sur cinq ans et portant sur l’analyse de 150 dossiers de patients hospitalisés pour une fibrillation atriale. RESULTATS: La fréquence de la fibrillation atriale était de 5,35 % et représentait 66% des troubles du rythme cardiaque avec une prédominance féminine (sex-ratio H/F = 0,45) et un âge moyen de 57,06 ± 18,64 ans. L’origine de la fibrillation était valvulaire dans 36,7% des cas. Les complications thromboemboliques étaient plus fréquentes dans la fibrillation atriale non valvulaire (p=0,006), chez les sujets d’âge > 50 ans (p=0,01) et en cas de dilatation de l’oreillette gauche (p=0,05). Une anticoagulation par anti-vitamine K était instaurée dans 62% des cas et un traitement de contrôle de la fréquence cardiaque dans 87,33%. CONCLUSION: La fibrillation atriale est fréquente en milieu hospitalier africain et concerne des sujets relativement jeunes. L’hypertension artérielle et les valvulopathies rhumatismales sont les principaux facteurs étiologiques. Le traitement reste essentiellement médicamenteux par contrôle de la fréquence cardiaque.
- Published
- 2010
28. Aphallia: A case report and literature review.
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Kane AD, Ngom G, Ndour O, and Alumeti DM
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- 2011
29. Differential effect of early versus late onset chronic hypoxemia on molecular mechanisms regulating lung maturation in the late gestation fetus
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McGillick, EV, Orgeig, S, Allison, BJ, Brain, KL, Niu, Y, Itani, N, Skeffington, KL, Kane, AD, Herrera, EA, Giussani, DA, and Morrison, JL
- Abstract
usc
- Published
- 2016
30. Maternal antioxidant treatment increases expression of genes regulating hypoxia signalling, sodium movement and surfactant maturation in the fetal lung
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McGillick, EV, Orgeig, S, Allison, BJ, Brain, KL, Niu, Y, Itani, N, Skeffington, KL, Kane, AD, Herrera, EA, Morrison, JL, and Giussani, DA
- Abstract
usc
- Published
- 2015
31. Cardiac arrest in adult cardiology patients receiving anaesthetic care: analysis from the 7th National Audit Project (NAP7) of the Royal College of Anaesthetists.
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Agarwal S, Armstrong RA, Kursumovic E, Kane AD, Cook TM, Soar J, Finney SJ, and Kunst G
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- Humans, Male, Female, Aged, Middle Aged, Adult, Medical Audit, Aged, 80 and over, Cardiopulmonary Resuscitation, United Kingdom, Extracorporeal Membrane Oxygenation, Heart Arrest therapy, Heart Arrest epidemiology, Anesthesia methods
- Abstract
Background: The 7th National Audit Project of the Royal College of Anaesthetists studied peri-operative cardiac arrest because of existing knowledge gaps in this important topic. This applies in particular to cardiology patients receiving anaesthetic care, because numbers, types and complexity of minimally invasive interventional procedures requiring planned and unplanned anaesthesia in the cardiac intervention suite is increasing., Methods: We analysed collected data to determine the epidemiology, clinical features, management and outcomes of peri-operative cardiac arrest in adult patients receiving anaesthetic care for cardiology procedures., Results: There were 54 reports of peri-operative cardiac arrest in adult patients receiving anaesthetic care for cardiology procedures, accounting for 54/881 (6.1%) of all reports to NAP7. The estimated incidence (95%CI) of cardiac arrests in this group was 1/450 or 0.22 (0.17-0.29)%. These patients were older than other adult patients in the NAP7 population, with a notably high proportion of patients of Asian ethnicity when compared with the remaining NAP7 cohort (9/54, 17% vs. 35/709, 5%). Rates of extracorporeal membrane oxygenation cardiopulmonary resuscitation were low (3/53, 6%). A common theme was that of logistical issues and teamworking, with reporters commenting on the difficulties of remote and/or unfamiliar locations and communication issues between specialties, on occasion resulting in poor teamworking and a lack of focus. The NAP7 panel review identified several other common themes which included: cardiogenic shock; late involvement of anaesthesia in the case; and transcatheter aortic valve implantation., Conclusion: Cardiology procedures requiring anaesthesia care account for < 1% of anaesthesia activity but generate 6% of all peri-operative cardiac arrests. The incidence of cardiac arrest was disproportionately high in cardiological procedures requiring anaesthetic care. The nature of the cardiac arrest reports to NAP7 indicate that logistical and human factors in multidisciplinary teams in the cardiac intervention suite merit addressing to improve care., (© 2024 Association of Anaesthetists.)
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- 2024
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32. NAP7 - what's the point?
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Soar J, Cook TM, Armstrong RA, Kursumovic E, Oglesby FC, and Kane AD
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- 2024
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33. Anaesthesia associates' clinical activity, case mix, supervision and involvement in peri-operative cardiac arrest: analysis from the 7th National Audit Project.
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Cook TM, Kane AD, Armstrong RA, Kursumovic E, Varney L, Moppett IK, and Soar J
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- Humans, United Kingdom, Anesthetists, Medical Audit, Anesthesiology, Male, Clinical Competence, Female, Heart Arrest epidemiology
- Abstract
Background: We analysed the clinical practice of anaesthesia associates in the UK, as reported to the 7th National Audit Project of the Royal College of Anaesthetists, and compared these with medically qualified anaesthetists., Methods: We included data from our baseline survey, activity survey and case registry as with other reports from the project., Results: Among 197 departments of anaesthesia, 52 (26%) employed anaesthesia associates. Of 10,009 responding anaesthesia care providers, 71 (< 1%) were anaesthesia associates, of whom 33 (47%) reporting working nights or weekends (compared with 97% of medically qualified anaesthetists in training and > 90% of consultants). Anaesthesia associates reported less training and confidence in managing peri-operative cardiac arrest and its aftermath compared with medically qualified anaesthetists. Anaesthesia associates were less directly involved in the management and the aftermath of peri-operative cardiac arrest than medically qualified anaesthetists, and the psychological impacts on professional and personal life appeared to be less. Among 24,172 cases, anaesthesia associates attended 432 (2%) and were the senior anaesthesia care provider in 63 (< 1%), with indirect supervision in 27 (43%). Anaesthesia associates worked predominantly in a small number of surgical specialties during weekdays and working daytime hours. Complication rates were low in cases managed by anaesthesia associates, likely reflecting case mix. However, activity and registry case mix data show anaesthesia associates do manage high-risk cases (patients who are older, comorbid, obese and frail) with the potential for serious complications. Registry cases included higher risk cases with respect to the clinical setting and patient factors., Conclusion: Anaesthesia associates work in enhanced roles, relative to the scope of practice at qualification agreed by organisations. Recent changes mean the Royal College of Anaesthetists and Association of Anaesthetists do not currently support an enhanced scope of practice., (© 2024 The Author(s). Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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34. Advanced life support interventions during intra-operative cardiac arrest among adults as reported to the 7th National Audit Project of the Royal College of Anaesthetists.
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Nolan JP, Armstrong RA, Kane AD, Kursumovic E, Davies MT, Moppett IK, Cook TM, and Soar J
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- Humans, Female, Male, Middle Aged, Aged, Adult, Intraoperative Complications epidemiology, Medical Audit, Advanced Cardiac Life Support, Cardiopulmonary Resuscitation methods, Aged, 80 and over, Heart Arrest therapy, Heart Arrest epidemiology
- Abstract
Background: Few existing resuscitation guidelines include specific reference to intra-operative cardiac arrest, but its optimal treatment is likely to require some adaptation of standard protocols., Methods: We analysed data from the 7th National Audit Project of the Royal College of Anaesthetists to determine the incidence and outcome from intra-operative cardiac arrest and to summarise the advanced life support interventions reported as being used by anaesthetists., Results: In the baseline survey, > 50% of anaesthetists responded that they would start chest compressions when the non-invasive systolic pressure was < 40-50 mmHg. Of the 881 registry patients, 548 were adult patients (aged > 18 years) having non-obstetric procedures under the care of an anaesthetist, and who had arrested during anaesthesia (from induction to emergence). Sustained return of spontaneous circulation was achieved in 425 (78%) patients and 338 (62%) were alive at the time of reporting. In the 365 patients with pulseless electrical activity or bradycardia, adrenaline was given as a 1 mg bolus in 237 (65%). A precordial thump was used in 14 (3%) patients, and although this was associated with return of spontaneous circulation at the next rhythm check in almost three-quarters of patients, in only one of these was the initial rhythm shockable. Calcium (gluconate or chloride) and 8.4% sodium bicarbonate were given to 51 (9%) and 25 (5%) patients, but there were specific indications for these treatments in less than half of the patients. A thrombolytic drug was given to 5 (1%) patients, and extracorporeal cardiopulmonary resuscitation was used in 9 (2%) of which eight occurred during cardiac procedures., Conclusions: The specific characteristics of intra-operative cardiac arrest imply that its optimal treatment requires modifications to standard advanced life support guidelines., (© 2024 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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35. Time for mandatory safety preparedness: a responsibility for individuals, hospitals and national bodies.
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Kane AD, Soar J, and Cook TM
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- 2024
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36. Peri-operative cardiac arrest in the older frail patient as reported to the 7th National Audit Project of the Royal College of Anaesthetists.
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Moppett IK, Kane AD, Armstrong RA, Kursumovic E, Soar J, and Cook TM
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- Humans, Aged, Female, Male, Aged, 80 and over, Medical Audit, Frailty epidemiology, Postoperative Complications epidemiology, United Kingdom epidemiology, Registries, Frail Elderly statistics & numerical data, Heart Arrest epidemiology
- Abstract
Frailty increases peri-operative risk, but details of its burden, clinical features and the risk of, and outcomes following, peri-operative cardiac arrest are lacking. As a preplanned analysis of the 7th National Audit Project of the Royal College of Anaesthetists, we described the characteristics of older patients living with frailty undergoing anaesthesia and surgery, and those reported to the peri-operative cardiac arrest case registry. In the activity survey, 1676 (26%) of 6466 patients aged > 65 y were reported as frail (Clinical Frailty Scale score ≥ 5). Increasing age and frailty were both associated with increasing comorbidities and the proportion of surgery undertaken as an emergency. Except in patients who were terminally ill (Clinical Frailty Scale score 9), increasing frailty was associated with an increased proportion of complex or major surgery. The rate of use of invasive arterial blood pressure monitoring was associated with frailty only until Clinical Frailty Scale score 5, and then plateaued or fell. Of 881 cardiac arrests reported to the 7th National Audit Project, 156 (18%) were in patients aged > 65 y and living with frailty, with an estimated incidence of 1 in 1204 (95%CI 1 in 1027-1412) and a mortality rate of 1 in 2020 (95%CI 1 in 1642-2488), approximately 2.6-fold higher than in adults who were not frail. Hip fracture, emergency laparotomy, emergency vascular surgery and urological surgery were the most common surgical procedures in older patients living with frailty who had a cardiac arrest. We report a high burden of frailty within the surgical population, requiring complex, urgent surgery, and the extent of poorer outcomes of peri-operative cardiac arrest compared with patients of the same age not living with frailty., (© 2024 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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37. [Senegal's experience with pacemakers re-use : about 161 patients at the Aristide Le Dantec university hospital center].
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Tabane A, Sarr SA, Aw F, Kane AD, and Defaye P
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- Humans, Male, Female, Retrospective Studies, Senegal, Aged, Middle Aged, Aged, 80 and over, Adult, Pacemaker, Artificial, Equipment Reuse, Hospitals, University
- Abstract
Introduction: The reuse pacemakers is a beneficial technique for patients in countries with a low economic standard of living where health care is almost non-existent. We offered to share the experience of Senegal on the reconditioning of pacemakers., Methodology: We conducted a retrospective study over a period from January 2015 to December 2020 including all patients who benefited from a reconditioned pacemaker for primary implantation or reimplantation. The criteria for reconditioning pacemakers are the absence of dysfunction or damage and a residual battery life of more than 5 years of the pacemaker. Refurbished pacemakers are acquired either from deceased families or from extraction centers. Sterilization is carried out using phenoxypropanol + benzalkonium chloride solution, 70% ethanol and ethylene oxide., Results: We collected 161 patients during the study period, including 77 men (48%) and 84 women (52%), i.e. a M/F sex ratio of 0.94. The average age of the population was 65 years. Functional symptomatology was dominated by syncope in 54%. Electrocardiographically, 72% of patients were in complete atrioventricular block. A primary implantation was noted in 91.5% of patients. The vascular approach most used during implantation was cephalic in 49.5% of cases. In our series, we noted that 58% of patients had benefited from temporary stimulation before implantation. At implantation, single-chamber stimulation was used in 60% of patients and 46.5% of patients had programming in VVI mode. We had 5.5% major complications with 3% box infection occurring between 3 and 6 months post-implantation and 2.5% pacemaker syndrome. We noted 1 case of death linked to underlying heart disease., Conclusion: Reconditioning of cardiac pacemakers is a safe and beneficial therapeutic strategy for patients. In Senegal, reconditioning has shown satisfactory results. In our countries this technique can be an alternative for certain patients., Competing Interests: Déclaration de liens d'intérêts Les auteurs déclarent n'avoir aucun lien d'intérêts en rapport avec l’étude., (Copyright © 2024 Elsevier Masson SAS. All rights reserved.)
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- 2024
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38. Peri-operative cardiac arrest in children as reported to the 7th National Audit Project of the Royal College of Anaesthetists.
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Oglesby FC, Scholefield BR, Cook TM, Smith JH, Pappachan VJ, Kane AD, Armstrong RA, Kursumovic E, and Soar J
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- Humans, Child, Infant, Infant, Newborn, United Kingdom epidemiology, Child, Preschool, Postoperative Complications epidemiology, Anesthesia adverse effects, Perioperative Care methods, Adolescent, Heart Arrest epidemiology, Medical Audit
- Abstract
The 7th National Audit Project of the Royal College of Anaesthetists studied peri-operative cardiac arrest. An activity survey estimated UK paediatric anaesthesia annual caseload as 390,000 cases, 14% of the UK total. Paediatric peri-operative cardiac arrests accounted for 104 (12%) reports giving an incidence of 3 in 10,000 anaesthetics (95%CI 2.2-3.3 per 10,000). The incidence of peri-operative cardiac arrest was highest in neonates (27, 26%), infants (36, 35%) and children with congenital heart disease (44, 42%) and most reports were from tertiary centres (88, 85%). Frequent precipitants of cardiac arrest in non-cardiac surgery included: severe hypoxaemia (20, 22%); bradycardia (10, 11%); and major haemorrhage (9, 8%). Cardiac tamponade and isolated severe hypotension featured prominently as causes of cardiac arrest in children undergoing cardiac surgery or cardiological procedures. Themes identified at review included: inappropriate choices and doses of anaesthetic drugs for intravenous induction; bradycardias associated with high concentrations of volatile anaesthetic agent or airway manipulation; use of atropine in the place of adrenaline; and inadequate monitoring. Overall quality of care was judged by the panel to be good in 64 (62%) cases, which compares favourably with adults (371, 52%). The study provides insight into paediatric anaesthetic practice, complications and peri-operative cardiac arrest., (© 2024 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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39. Peri-operative cardiac arrest due to suspected anaphylaxis as reported to the 7th National Audit Project of the Royal College of Anaesthetists.
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Cook TM, Kane AD, Armstrong RA, Kursumovic E, and Soar J
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- Humans, Epinephrine, Anesthetists, Anaphylaxis epidemiology, Anaphylaxis etiology, Anaphylaxis therapy, Bronchial Spasm, Heart Arrest etiology, Heart Arrest therapy
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The 7th National Audit Project (NAP7) of the Royal College of Anaesthetists studied peri-operative cardiac arrest. Among 59 cases reported as possible anaphylaxis, 33 (56%) were judged to be so by the review panel with high or moderate confidence. Causes in excluded cases included: isolated severe hypotension; bronchospasm; and oesophageal intubation. Severe bronchospasm leading to cardiac arrest was uncommon, but notably in one case led to a reported flat capnograph. In the baseline survey, anaesthetists estimated anaphylaxis as the cause of 10% of cases of peri-operative cardiac arrests and to be among the four most common causes. In a year-long registry of peri-operative cardiac arrest, suspected anaphylaxis was the seventh most common cause accounting for 4% of reports. Initial management was most often with low-dose intravenous adrenaline, and this was without complications. Both the NAP7 baseline survey and case registry provided evidence of reluctance to starting chest compressions when systolic blood pressure had fallen to below 50 mmHg and occasionally even when it was unrecordable. All 33 patients were resuscitated successfully but one patient later died. The one death occurred in a relatively young patient in whom chest compressions were delayed. Overall, peri-operative anaphylaxis leading to cardiac arrest occurred with a similar frequency and patterns of presentation, location, initial rhythm and suspected triggers in NAP7 as in the 6th National Audit Project (NAP6). Outcomes in NAP7 were generally better than for equivalent cases in NAP6., (© 2024 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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40. Cardiac arrest in obstetric patients receiving anaesthetic care: results from the 7th National Audit Project of the Royal College of Anaesthetists.
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Lucas DN, Kursumovic E, Cook TM, Kane AD, Armstrong RA, Plaat F, and Soar J
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- Pregnancy, Female, Humans, Remifentanil, Anesthetists, Anesthetics, Anesthesia, Obstetrical adverse effects, Heart Arrest epidemiology, Heart Arrest etiology
- Abstract
The 7th National Audit Project (NAP7) of the Royal College of Anaesthetists studied peri-operative cardiac arrest. Additional inclusion criteria for obstetric anaesthesia were: cardiac arrest associated with neuraxial block performed by an anaesthetist outside the operating theatre (labour epidural analgesia); and cardiac arrest associated with remifentanil patient-controlled analgesia. There were 28 cases of cardiac arrest in obstetric patients, representing 3% of all cardiac arrests reported to NAP7, giving an incidence of 7.9 per 100,000 (95%CI 5.4-11.4 per 100,000). Obstetric patients were approximately four times less likely to have a cardiac arrest during anaesthesia care than patients having non-obstetric surgery. The single leading cause of peri-operative cardiac arrest in obstetric patients was haemorrhage, with underestimated severity and inadequate early resuscitation being contributory factors. When taken together, anaesthetic causes, high neuraxial block and bradyarrhythmia associated with spinal anaesthesia were the leading causes overall. Two patients had a cardiac arrest related to labour neuraxial analgesia. There were no cardiac arrests related to failed airway management or remifentanil patient-controlled analgesia., (© 2024 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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41. Cardiac arrest in vascular surgical patients receiving anaesthetic care: an analysis from the 7th National Audit Project (NAP7) of the Royal College of Anaesthetists.
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Armstrong RA, Cook TM, Kunst G, Kane AD, Kursumovic E, Lucas DN, Nickols G, Soar J, and Mouton R
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- Humans, Vascular Surgical Procedures, Anesthetists, Anesthetics, Anesthesia adverse effects, Heart Arrest epidemiology, Heart Arrest therapy, Heart Arrest etiology
- Abstract
The 7th National Audit Project of the Royal College of Anaesthetists studied peri-operative cardiac arrest in the UK. We report the results of the vascular surgery cohort from the 12-month case registry, from 16 June 2021 to 15 June 2022. Anaesthesia for vascular surgery accounted for 2% of UK anaesthetic caseload and included 69 (8%) reported peri-operative cardiac arrests, giving an estimated incidence of 1 in 670 vascular anaesthetics (95%CI 1 in 520-830). The high-risk nature of the vascular population is reflected by the proportion of patients who were ASA physical status 4 (30, 43%) or 5 (19, 28%); the age of patients (80% aged > 65 y); and that most cardiac arrests (57, 83%) occurred during non-elective surgery. The most common vascular surgical procedures among patients who had a cardiac arrest were: aortic surgery (38, 55%); lower-limb revascularisation (13, 19%); and lower-limb amputation (8, 12%). Among patients having vascular surgery and who had a cardiac arrest, 28 (41%) presented with a ruptured abdominal aortic aneurysm. There were 48 (70%) patients who had died at the time of reporting to NAP7 and 11 (16%) were still in hospital, signifying poorer outcomes compared with the non-vascular surgical cohort. The most common cause of cardiac arrest was major haemorrhage (39, 57%), but multiple other causes reflected the critical illness of the patients and the complexity of surgery. This is the first analysis of the incidence, management and outcomes of peri-operative cardiac arrest during vascular anaesthesia in the UK., (© 2024 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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42. Independent sector and peri-operative cardiac arrest as reported to the 7th National Audit Project of the Royal College of Anaesthetists.
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Cook TM, Kane AD, Bouch C, Armstrong RA, Kursumovic E, and Soar J
- Subjects
- Humans, Elective Surgical Procedures, Anesthetists, Obesity, Heart Arrest epidemiology, Heart Arrest therapy, Anaphylaxis
- Abstract
The 7th National Audit Project (NAP7) of the Royal College of Anaesthetists studied peri-operative cardiac arrest including those that occurred in the independent healthcare sector, which provides around 1 in 6 NHS-funded care episodes. In total, 174 (39%) of 442 independent hospitals contacted agreed to participate. A survey examining provider preparedness for cardiac arrest had a response rate of 23 (13%), preventing useful analysis. An activity survey with 1912 responses (from a maximum of 45% of participating hospitals) showed that, compared with the NHS caseload, the independent sector caseload was less comorbid, with fewer patients at the extremes of age or who were severely obese, and with a large proportion of elective orthopaedic surgery undertaken during weekday working hours. The survey suggested suboptimal compliance rates with monitoring recommendations. Seventeen reports of independent sector peri-operative cardiac arrest comprised 2% of NAP7 reports and underreporting is likely. These patients were lower risk than NHS cases, reflecting the sector's case mix, but included cases of haemorrhage, anaphylaxis, cardiac arrhythmia and pulmonary embolus. Good and poor quality care were seen, the latter including delayed recognition and treatment of patient deterioration, and poor care delivery. Independent sector outcomes were similar to those in the NHS, though due to the case mix, improved outcomes might be anticipated. Assessment of quality of care was less often favourable for independent sector reports than NHS reports, though assessments were often uncertain, reflecting poor quality reports. Overall, NAP7 is unable to determine whether peri-operative care relating to cardiac arrest is more, equally or less safe than in the NHS., (© 2024 Association of Anaesthetists.)
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- 2024
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43. Airway and respiratory complications during anaesthesia and associated with peri-operative cardiac arrest as reported to the 7th National Audit Project of the Royal College of Anaesthetists.
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Cook TM, Oglesby F, Kane AD, Armstrong RA, Kursumovic E, and Soar J
- Subjects
- Child, Infant, Humans, Child, Preschool, Airway Management adverse effects, Airway Management methods, Hypoxia, Respiratory Aspiration, Intubation, Respiratory System, Anesthetists, Intubation, Intratracheal adverse effects, Anesthesia adverse effects, Heart Arrest epidemiology, Heart Arrest etiology, Heart Arrest therapy
- Abstract
The 7th National Audit Project (NAP7) of the Royal College of Anaesthetists studied complications of the airway and respiratory system during anaesthesia care including peri-operative cardiac arrest. Among 24,721 surveyed cases, airway and respiratory complications occurred commonly (n = 421 and n = 264, respectively). The most common airway complications were: laryngospasm (157, 37%); airway failure (125, 30%); and aspiration (27, 6%). Emergency front of neck airway was rare (1 in 8370, 95%CI 1 in 2296-30,519). The most common respiratory complications were: severe ventilation difficulty (97, 37%); hyper/hypocapnia (63, 24%); and hypoxaemia (62, 23%). Among 881 reports to NAP7 and 358 deaths, airway and respiratory complications accounted for 113 (13%) peri-operative cardiac arrests and 32 (9%) deaths, with hypoxaemia as the most common primary cause. Airway and respiratory cases had higher and lower survival rates than other causes of cardiac arrest, respectively. Patients with obesity, young children (particularly infants) and out-of-hours care were overrepresented in reports. There were six cases of unrecognised oesophageal intubation with three resulting in cardiac arrest. Of these cases, failure to correctly interpret capnography was a recurrent theme. Cases of emergency front of neck airway (6, approximately 1 in 450,000) and pulmonary aspiration (11, approximately 1 in 25,000) leading to cardiac arrest were rare. Overall, these data, while distinct from the 4th National Audit Project, suggest that airway management is likely to have become safer in the last decade, despite the surgical population having become more challenging for anaesthetists., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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44. Peri-operative decisions about cardiopulmonary resuscitation among adults as reported to the 7th National Audit Project of the Royal College of Anaesthetists.
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Nolan JP, Soar J, Kane AD, Moppett IK, Armstrong RA, Kursumovic E, and Cook TM
- Subjects
- Adult, Humans, Resuscitation Orders, Hospitals, Anesthetists, Cardiopulmonary Resuscitation, Heart Arrest therapy
- Abstract
Current guidance recommends that, in most circumstances, cardiopulmonary resuscitation should be attempted when cardiac arrest occurs during anaesthesia, and when a patient has a pre-existing 'do not attempt cardiopulmonary resuscitation' recommendation, this should be suspended. How this guidance is translated into everyday clinical practice in the UK is currently unknown. Here, as part of the 7th National Audit Project of the Royal College of Anaesthetists, we have: assessed the rates of pre-operative 'do not attempt cardiopulmonary resuscitation' recommendations via an activity survey of all cases undertaken by anaesthetists over four days in each participating site; and analysed our one-year case registry of peri-operative cardiac arrests to understand the rates of cardiac arrest in patients who had 'do not attempt cardiopulmonary resuscitation' decisions pre-operatively. In the activity survey, among 20,717 adults (aged > 18 y) undergoing surgery, 595 (3%) had a 'do not attempt cardiopulmonary resuscitation' recommendation pre-operatively, of which less than a third (175, 29%) were suspended. Of the 881 peri-operative cardiac arrest reports, 54 (6%) patients had a 'do not attempt cardiopulmonary resuscitation' recommendation made pre-operatively and of these 38 (70%) had a clinical frailty scale score ≥ 5. Just under half (25, 46%) of these 'do not attempt cardiopulmonary resuscitation' recommendations were formally suspended at the time of anaesthesia and surgery. One in five of these patients with a 'do not attempt cardiopulmonary resuscitation' recommendation who had a cardiac arrest survived to leave hospital and of the seven patients with documented modified Rankin Scale scores before and after cardiac arrest, four remained the same and three had worse scores. Very few patients who had a pre-existing 'do not attempt cardiopulmonary resuscitation' recommendation had a peri-operative cardiac arrest, and when cardiac arrest did occur, return of spontaneous circulation was achieved in 57%, although > 50% of these patients subsequently died before discharge from hospital., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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45. Peri-operative cardiac arrest: epidemiology and clinical features of patients analysed in the 7th National Audit Project of the Royal College of Anaesthetists.
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Armstrong RA, Soar J, Kane AD, Kursumovic E, Nolan JP, Oglesby FC, Cortes L, Taylor C, Moppett IK, Agarwal S, Cordingley J, Davies MT, Dorey J, Finney SJ, Kendall S, Kunst G, Lucas DN, Mouton R, Nickols G, Pappachan VJ, Patel B, Plaat F, Scholefield BR, Smith JH, Varney L, Wain E, and Cook TM
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Anesthesia, Anesthetics, Anesthetists, Infant, Heart Arrest epidemiology, Heart Arrest etiology
- Abstract
The 7th National Audit Project of the Royal College of Anaesthetists studied peri-operative cardiac arrest in the UK, a topic of importance to patients, anaesthetists and surgeons. Here we report the results of the 12-month registry, from 16 June 2021 to 15 June 2022, focusing on epidemiology and clinical features. We reviewed 881 cases of peri-operative cardiac arrest, giving an incidence of 3 in 10,000 anaesthetics (95%CI 3.0-3.5 per 10,000). Incidence varied with patient and surgical factors. Compared with denominator survey activity, patients with cardiac arrest: included more males (56% vs. 42%); were older (median (IQR) age 60.5 (40.5-80.5) vs. 50.5 (30.5-70.5) y), although the age distribution was bimodal, with infants and patients aged > 66 y overrepresented; and were notably more comorbid (73% ASA physical status 3-5 vs. 27% ASA physical status 1-2). The surgical case-mix included more weekend (14% vs. 11%), out-of-hours (19% vs. 10%), non-elective (65% vs. 30%) and major/complex cases (60% vs. 28%). Cardiac arrest was most prevalent in orthopaedic trauma (12%), lower gastrointestinal surgery (10%), cardiac surgery (9%), vascular surgery (8%) and interventional cardiology (6%). Specialities with the highest proportion of cases relative to denominator activity were: cardiac surgery (9% vs. 1%); cardiology (8% vs. 1%); and vascular surgery (8% vs. 2%). The most common causes of cardiac arrest were: major haemorrhage (17%); bradyarrhythmia (9%); and cardiac ischaemia (7%). Patient factors were judged a key cause of cardiac arrest in 82% of cases, anaesthesia in 40% and surgery in 35%., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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46. The incidence of potentially serious complications during non-obstetric anaesthetic practice in the United Kingdom: an analysis from the 7th National Audit Project (NAP7) activity survey.
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Kane AD, Cook TM, Armstrong RA, Kursumovic E, Davies MT, Agarwal S, Nolan JP, Smith JH, Moppett IK, Oglesby FC, Cortes L, Taylor C, Cordingley J, Dorey J, Finney SJ, Kunst G, Lucas DN, Nickols G, Mouton R, Patel B, Pappachan VJ, Plaat F, Scholefield BR, Varney L, and Soar J
- Subjects
- Female, Pregnancy, Humans, Male, Incidence, Prospective Studies, Hemorrhage, United Kingdom epidemiology, Anesthetics, Anesthesia adverse effects
- Abstract
Complications and critical incidents arising during anaesthesia due to patient, surgical or anaesthetic factors, may cause harm themselves or progress to more severe events, including cardiac arrest or death. As part of the 7th National Audit Project of the Royal College of Anaesthetists, we studied a prospective national cohort of unselected patients. Anaesthetists recorded anonymous details of all cases undertaken over 4 days at their site through an online survey. Of 416 hospital sites invited to participate, 352 (85%) completed the survey. Among 24,172 cases, 1922 discrete potentially serious complications were reported during 1337 (6%) cases. Obstetric cases had a high reported major haemorrhage rate and were excluded from further analysis. Of 20,996 non-obstetric cases, 1705 complications were reported during 1150 (5%) cases. Circulatory events accounted for most complications (616, 36%), followed by airway (418, 25%), metabolic (264, 15%), breathing (259, 15%), and neurological (41, 2%) events. A single complication was reported in 851 (4%) cases, two complications in 166 (1%) cases and three or more complications in 133 (1%) cases. In non-obstetric elective surgery, all complications were 'uncommon' (10-100 per 10,000 cases). Emergency (urgent and immediate priority) surgery accounted for 3454 (16%) of non-obstetric cases but 714 (42%) of complications with severe hypotension, major haemorrhage, severe arrhythmias, septic shock, significant acidosis and electrolyte disturbances all being 'common' (100-1000 per 10,000 cases). Based on univariate analysis, complications were associated with: younger age; higher ASA physical status; male sex; increased frailty; urgency and extent of surgery; day of the week; and time of day. These data represent the rates of potentially serious complications during routine anaesthesia care and may be valuable for risk assessment and patient consent., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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47. Observed gaps in UK anaesthetic monitoring practice.
- Author
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Kane AD, Davies MT, Armstrong RA, Kursumovic E, Soar J, and Cook TM
- Subjects
- Humans, Monitoring, Intraoperative, Drug Monitoring, United Kingdom, Anesthesia, Anesthetics
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- 2024
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48. Peri-operative cardiac arrest: management and outcomes of patients analysed in the 7th National Audit Project of the Royal College of Anaesthetists.
- Author
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Armstrong RA, Cook TM, Kane AD, Kursumovic E, Nolan JP, Oglesby FC, Cortes L, Taylor C, Moppett IK, Agarwal S, Cordingley J, Davies MT, Dorey J, Finney SJ, Kendall S, Kunst G, Lucas DN, Mouton R, Nickols G, Pappachan VJ, Patel B, Plaat F, Scholefield BR, Smith JH, Varney L, Wain E, and Soar J
- Subjects
- Infant, Newborn, Humans, Registries, Anesthetists, Cardiopulmonary Resuscitation methods, Heart Arrest epidemiology, Heart Arrest therapy, Pulmonary Embolism
- Abstract
The 7th National Audit Project of the Royal College of Anaesthetists studied peri-operative cardiac arrest in the UK, a topic of importance to patients, anaesthetists and surgeons. We report the results of the 12-month registry phase, from 16 June 2021 to 15 June 2022, focusing on management and outcomes. Among 881 cases of peri-operative cardiac arrest, the initial rhythm was non-shockable in 723 (82%) cases, most commonly pulseless electrical activity. There were 665 (75%) patients who survived the initial event and 384 (52%) who survived to hospital discharge. A favourable functional outcome (based on modified Rankin Scale score) was reported for 249 (88%) survivors. Outcomes varied according to arrest rhythm. The highest rates of survival were seen for bradycardic cardiac arrests with 111 (86%) patients surviving the initial event and 77 (60%) patients surviving the hospital episode. The lowest survival rates were seen for patients with pulseless electrical activity, with 312 (68%) surviving the initial episode and 156 (34%) surviving to hospital discharge. Survival to hospital discharge was worse in patients at the extremes of age with 76 (40%) patients aged > 75 y and 9 (45%) neonates surviving. Hospital survival was also associated with surgical priority, with 175 (88%) elective patients and 176 (37%) non-elective patients surviving to discharge. Outcomes varied with the cause of cardiac arrest, with lower initial survival rates for pulmonary embolism (5, 31%) and bone cement implantation syndrome (9, 45%), and hospital survival of < 25% for pulmonary embolism (0), septic shock (13, 24%) and significant hyperkalaemia (1, 20%). Overall care was rated good in 464 (53%) cases, and 18 (2%) cases had overall care rated as poor. Poor care elements were present in a further 245 (28%) cases. Care before cardiac arrest was the phase most frequently rated as poor (92, 11%) with elements of poor care identified in another 186 (21%) cases. These results describe the management and outcomes of peri-operative cardiac arrest in UK practice for the first time., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
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- 2024
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49. The 7th National Audit Project (NAP7) baseline survey of individual anaesthetists: preparedness for and experiences of peri-operative cardiac arrest.
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Kursumovic E, Cook TM, Lucas DN, Davies MT, Martin S, Kane AD, Armstrong RA, Oglesby FC, Cortes L, Taylor C, Moppett IK, Agarwal S, Beecham E, Cordingley J, Dorey J, Finney SJ, Kunst G, Nickols G, Mouton R, Nolan JP, Patel B, Pappachan VJ, Plaat F, Scholefield BR, Smith JH, Varney L, Wain EC, and Soar J
- Subjects
- Adult, Male, Female, Humans, Child, Surveys and Questionnaires, Anesthetists, Hemorrhage, Ischemia, Heart Arrest
- Abstract
The Royal College of Anaesthetists' 7th National Audit Project baseline survey assessed knowledge, attitudes, practices and experiences of peri-operative cardiac arrests among UK anaesthetists and Anaesthesia Associates. We received 10,746 responses, representing a 71% response rate. In-date training in adult and paediatric advanced life support was reported by 9646 (90%) and 7125 (66%) anaesthetists, respectively. There were 8994 (84%) respondents who were confident in leading a peri-operative cardiac arrest, with males more confident than females, but only 5985 (56%) were confident in leading a debrief and 7340 (68%) communicating with next of kin. In the previous two years, 4806 (46%) respondents had managed at least one peri-operative cardiac arrest, of which 321 (7%) and 189 (4%) of these events involved a child or an obstetric patient, respectively. Respondents estimated the most common causes of peri-operative cardiac arrest to be hypovolaemia, hypoxaemia and cardiac ischaemia, with haemorrhage coming fifth. However, the most common reported causes for the most recently attended peri-operative cardiac arrest were haemorrhage; (927, 20%); anaphylaxis (474, 10%); and cardiac ischaemia (397, 9%). Operating lists or shifts were paused or stopped after 1330 (39%) cardiac arrests and 1693 (38%) respondents attended a debrief, with 'hot' debriefs most common. Informal wellbeing support was relatively common (2458, 56%) and formal support was uncommon (472, 11%). An impact on future care delivery was reported by 196 (4%) anaesthetists, most commonly a negative psychological impact. Management of a peri-operative cardiac arrest during their career was reported by 8654 (85%) respondents. The overall impact on professional life was more often judged positive (2630, 30%) than negative (1961, 23%), but impact on personal life was more often negative., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
- Published
- 2023
- Full Text
- View/download PDF
50. Organisation of UK hospitals and anaesthetic departments in the treatment of peri-operative cardiac arrest: an analysis from the 7th National Audit Project (NAP7) local co-ordinator baseline survey.
- Author
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Kursumovic E, Soar J, Nolan JP, Plaat F, Kane AD, Armstrong RA, Davies MT, Oglesby FC, Cortes L, Taylor C, Moppett IK, Agarwal S, Cordingley J, Dorey J, Finney SJ, Kunst G, Lucas DN, Nickols G, Mouton R, Patel B, Pappachan VJ, Scholefield BR, Smith JH, Varney L, and Cook TM
- Subjects
- Adult, Child, Humans, Surveys and Questionnaires, Hospitals, United Kingdom, Anesthetics, Heart Arrest
- Abstract
We report the results of the Royal College of Anaesthetists' 7th National Audit Project organisational baseline survey sent to every NHS anaesthetic department in the UK to assess preparedness for treating peri-operative cardiac arrest. We received 199 responses from 277 UK anaesthetic departments, representing a 72% response rate. Adult and paediatric anaesthetic care was provided by 188 (95%) and 165 (84%) hospitals, respectively. There was no paediatric intensive care unit on-site in 144 (87%) hospitals caring for children, meaning transfer of critically ill children is required. Remote site anaesthesia is provided in 182 (92%) departments. There was a departmental resuscitation lead in 113 (58%) departments, wellbeing lead in 106 (54%) and departmental staff wellbeing policy in 81 (42%). A defibrillator was present in every operating theatre suite and in all paediatric anaesthesia locations in 193 (99%) and 149 (97%) departments, respectively. Advanced airway equipment was not available in: every theatre suite in 13 (7%) departments; all remote locations in 103 (57%) departments; and all paediatric anaesthesia locations in 23 (15%) departments. Anaesthetic rooms were the default location for induction of anaesthesia in adults and children in 148 (79%) and 121 (79%) departments, respectively. Annual updates in chest compressions and in defibrillation were available in 149 (76%) and 130 (67%) departments, respectively. Following a peri-operative cardiac arrest, debriefing and peer support programmes were available in 154 (79%) and 57 (29%) departments, respectively. While it is likely many UK hospitals are very well prepared to treat anaesthetic emergencies including cardiac arrest, the survey suggests this is not universal., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
- Published
- 2023
- Full Text
- View/download PDF
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