Search

Your search keyword '"Kandemir, H"' showing total 190 results
Start Over Author "Kandemir, H"
190 results on '"Kandemir, H"'

1. Prevalence, comorbidities and mediators of childhood anxiety disorders in urban Turkey: a national representative epidemiological study

Author

Mutluer, T., Gorker, I., Akdemir, D., Ozdemir, D. Foto, Ozel, O. Ozcan, Vural, P., Tufan, A. E., Karacetin, G., Arman, A. Rodopman, Fis, N. Perdahli, Demirci, E., Ozmen, S., Hesapcioglu, S. Tural, Oztop, D., Tural, U., Aktepe, E., Aksu, H., Ardic, U. Akyol, Basgul, S., Bilac, O., Coskun, M., Celik, G. G., Demirkaya, S. Karakoc, Dursun, O. B., Durukan, I., Fidan, T., Gokcen, C., Gormez, V., Gundogdu, O. Yildiz, Herguner, S., Kandemir, H., Kilic, B. Gunay, Kilincaslan, A., Nasiroglu, S., Sapmaz, S. Yalin, Sahin, N., Tahiroglu, A. Y., Toros, F., Unal, F., Yazici, I. Percinel, Yazici, K. U., Isik, U., and Ercan, E. S.

Published
2022
Full Text
View/download PDF

4. What are the 100 most cited fungal genera?

Author

Bhunjun, C.S., Chen, Y.J., Phukhamsakda, C., Boekhout, T., Groenewald, J.Z., Mckenzie, E.H.C., Francisco, E.C., Frisvad, J.C., Groenewald, M., Hurdeal, V.G., Luangsa-Ard, J., Perrone, G., Visagie, C.M., Bai, F.Y., Błaszkowski, J., Braun, U., de Souza, F.A., de Queiroz, M.B., Dutta, A.K., Gonkhom, D., Goto, B.T., Guarnaccia, V., Hagen, F., Houbraken, J., Lachance, M.A., Li, J.J., Luo, K.Y., Magurno, F., Mongkolsamrit, S., Robert, V., Roy, N., Tibpromma, S., Wanasinghe, D.N., Wang, D.Q., Wei, D.P., Zhao, C.L., Aiphuk, W., Ajayi-Oyetunde, O., Arantes, T.D., Araujo, J.C., Begerow, D., Bakhshi, M., Barbosa, R.N., Behrens, F.H., Bensch, K., Bezerra, J.D.P., Bilaski, P., Bradley, C.A., Bubner, B., Burgess, T.I., Buyck, B., Adež, N., Cai, L., Calaça, F.J.S., Campbell, L.J., Chaverri, P., Chethana, K.W.T., Coetzee, B., Costa, M.M., Chen, Q., Custódio, F.A., Dai, Y.C., Damm, U., Santiago, A.L.C.M.A., De Angelini, R.M. Miccolis, Dijksterhuis, J., Dissanayake, A.J., Doilom, M., Dong, W., álvarez-Duarte, E., Fischer, M., Gajanayake, A.J., Gené, J., Gomdola, D., Gomes, A.A.M., Hausner, G., He, M.Q., Hou, L., Iturrieta-González, I., Jami, F., Jankowiak, R., Jayawardena, R.S., Kandemir, H., Kiss, L., Kobmoo, N., Kowalski, T., Landi, L., Lin, C.G., Liu, J.K., Liu, X.B., Loizides, M., Luangharn, T., Maharachchikumbura, S.S.N., Mkhwanazi, G.J. Makhathini, Manawasinghe, I.S., Marin-Felix, Y., Mctaggart, A.R., Moreau, P.A., Morozova, O.V., Mostert, L., Osiewacz, H.D., Pem, D., Phookamsak, R., Pollastro, S., Pordel, A., Poyntner, C., Phillips, A.J.L., Phonemany, M., Promputtha, I., Rathnayaka, A.R., Rodrigues, A.M., Romanazzi, G., Rothmann, L., Salgado-Salazar, C., Sandoval-Denis, M., Saupe, S.J., Scholler, M., Scott, P., Shivas, R.G., Silar, P., Silva-Filho, A.G.S., Souza-Motta, C.M., Spies, C.F.J., Stchigel, A.M., Sterflinger, K., Summerbell, R.C., Svetasheva, T.Y., Takamatsu, S., Theelen, B., Theodoro, R.C., Thines, M., Thongklang, N., Torres, R., Turchetti, B., Van Den Brule, T., Wang, X.W., Wartchow, F., Welti, S., Wijesinghe, S.N., Wu, F., Xu, R., Yang, Z.L., Yilmaz, N., Yurkov, A., Zhao, L., Zhao, R.L., Zhou, N., Hyde, K.D., Crous, P.W., Bhunjun, C.S., Chen, Y.J., Phukhamsakda, C., Boekhout, T., Groenewald, J.Z., Mckenzie, E.H.C., Francisco, E.C., Frisvad, J.C., Groenewald, M., Hurdeal, V.G., Luangsa-Ard, J., Perrone, G., Visagie, C.M., Bai, F.Y., Błaszkowski, J., Braun, U., de Souza, F.A., de Queiroz, M.B., Dutta, A.K., Gonkhom, D., Goto, B.T., Guarnaccia, V., Hagen, F., Houbraken, J., Lachance, M.A., Li, J.J., Luo, K.Y., Magurno, F., Mongkolsamrit, S., Robert, V., Roy, N., Tibpromma, S., Wanasinghe, D.N., Wang, D.Q., Wei, D.P., Zhao, C.L., Aiphuk, W., Ajayi-Oyetunde, O., Arantes, T.D., Araujo, J.C., Begerow, D., Bakhshi, M., Barbosa, R.N., Behrens, F.H., Bensch, K., Bezerra, J.D.P., Bilaski, P., Bradley, C.A., Bubner, B., Burgess, T.I., Buyck, B., Adež, N., Cai, L., Calaça, F.J.S., Campbell, L.J., Chaverri, P., Chethana, K.W.T., Coetzee, B., Costa, M.M., Chen, Q., Custódio, F.A., Dai, Y.C., Damm, U., Santiago, A.L.C.M.A., De Angelini, R.M. Miccolis, Dijksterhuis, J., Dissanayake, A.J., Doilom, M., Dong, W., álvarez-Duarte, E., Fischer, M., Gajanayake, A.J., Gené, J., Gomdola, D., Gomes, A.A.M., Hausner, G., He, M.Q., Hou, L., Iturrieta-González, I., Jami, F., Jankowiak, R., Jayawardena, R.S., Kandemir, H., Kiss, L., Kobmoo, N., Kowalski, T., Landi, L., Lin, C.G., Liu, J.K., Liu, X.B., Loizides, M., Luangharn, T., Maharachchikumbura, S.S.N., Mkhwanazi, G.J. Makhathini, Manawasinghe, I.S., Marin-Felix, Y., Mctaggart, A.R., Moreau, P.A., Morozova, O.V., Mostert, L., Osiewacz, H.D., Pem, D., Phookamsak, R., Pollastro, S., Pordel, A., Poyntner, C., Phillips, A.J.L., Phonemany, M., Promputtha, I., Rathnayaka, A.R., Rodrigues, A.M., Romanazzi, G., Rothmann, L., Salgado-Salazar, C., Sandoval-Denis, M., Saupe, S.J., Scholler, M., Scott, P., Shivas, R.G., Silar, P., Silva-Filho, A.G.S., Souza-Motta, C.M., Spies, C.F.J., Stchigel, A.M., Sterflinger, K., Summerbell, R.C., Svetasheva, T.Y., Takamatsu, S., Theelen, B., Theodoro, R.C., Thines, M., Thongklang, N., Torres, R., Turchetti, B., Van Den Brule, T., Wang, X.W., Wartchow, F., Welti, S., Wijesinghe, S.N., Wu, F., Xu, R., Yang, Z.L., Yilmaz, N., Yurkov, A., Zhao, L., Zhao, R.L., Zhou, N., Hyde, K.D., and Crous, P.W.

Abstract

The global diversity of fungi has been estimated between 2 to 11 million species, of which only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they represent a major component of biodiversity on our planet, and play essential ecological roles, supporting life as we know it. Although approximately 20 000 fungal genera are presently recognised, the ecology of most remains undetermined. Despite all this diversity, the mycological community actively researches some fungal genera more commonly than others. This poses an interesting question: why have some fungal genera impacted mycology and related fields more than others? To address this issue, we conducted a bibliometric analysis to identify the top 100 most cited fungal genera. A thorough database search of the Web of Science, Google Scholar, and PubMed was performed to establish which genera are most cited. The most cited 10 genera are Saccharomyces, Candida, Aspergillus, Fusarium, Penicillium, Trichoderma, Botrytis, Pichia, Cryptococcus and Alternaria. Case studies are presented for the 100 most cited genera with general background, notes on their ecology and economic significance and important research advances. This paper provides a historic overview of scientific research of these genera and the prospect for further research.

Published
2024

5. Fungal Planet description sheets: 1614-1696

Author

Crous, P.W., Jurjević, Ž., Balashov, S., De la Peña-Lastra, S., Mateos, A., Pinruan, U., Rigueiro-Rodríguez, A., Osiek, E.R., Altés, A., Czachura, P., Esteve-Raventós, F., Gunaseelan, S., Kaliyaperumal, M., Larsson, E., Luangsa-ard, J.J., Moreno, G., Pancorbo, F., Piątek, M., Sommai, S., Somrithipol, S., Asif, M., Delgado, G., Flakus, A., Illescas, A., Kezo, K., Khamsuntorn, P., Kubátová, A., Labuda, R., Lavoise, C., Lebel, T., Lueangjaroenkit, P., Maciá-Vicente, J.G., Paz, A., Saba, M., Shivas, R.G., Tan, Y.P., Wingfield, M.J., Aas, T., Abramczyk, B., Ainsworth, A.M., Akulov, A., Alvarado, P., Armada, F., Assyov, B., Avchar, R., Avesani, M., Bezerra, J.L., Bhat, J.D., Bilański, P., Bily, D.S., Boccardo, F., Bozok, F., Campos, J.C., Chaimongkol, S., Chellappan, N., Costa, M.M., Dalecká, M., Darmostuk, V., Daskalopoulos, V., Dearnaley, J., Dentinger, B.T.M., De Silva, N.I., Dhotre, D., Carlavilla, J.R., Doungsa-ard, C., Dovana, F., Erhard, A., Ferro, L.O., Gallegos, S.C., Giles, C.E., Gore, G., Gorfer, M., Guard, F.E., Hanson, S.-Å., Haridev, P., Jankowiak, R., Jeffers, S.N., Kandemir, H., Karich, A., Kisło, K., Kiss, L., Krisai-Greilhuber, I., Latha, K.P.D., Lorenzini, M., Lumyong, S., Manimohan, P., Manjón, J.L., Maula, F., Mazur, E., Mesquita, N.L.S., Młynek, K., Mongkolsamrit, S., Morán, P., Murugadoss, R., Nagarajan, M., Nalumpang, S., Noisripoom, W., Nosalj, S., Novaes, Q.S., Nowak, M., Pawłowska, J., Peiger, M., Pereira, O.L., Pinto, A., Plaza, M., Polemis, E., Polhorský, A., Ramos, D.O., Raza, M., Rivas-Ferreiro, M., Rodrigues-Flakus, P., Ruszkiewicz-Michalska, M., Sánchez, A., Santos, A., Schüller, A., Scott, P.A., Şen, İ, Shelke, D., Śliwa, L., Solheim, H., Sonawane, H., Strašiftáková, D., Stryjak-Bogacka, M., Sudsanguan, M., Suwannarach, N., Suz, L.M., Syme, K., Taşkın, H., Tennakoon, D.S., Tomka, P., Vaghefi, N., Vasan, V., Vauras, J., Wiktorowicz, D., Villarreal, M., Vizzini, A., Wrzosek, M., Yang, X., Yingkunchao, W., Zapparoli, G., Zervakis, G.I., Groenewald, J.Z., Crous, P.W., Jurjević, Ž., Balashov, S., De la Peña-Lastra, S., Mateos, A., Pinruan, U., Rigueiro-Rodríguez, A., Osiek, E.R., Altés, A., Czachura, P., Esteve-Raventós, F., Gunaseelan, S., Kaliyaperumal, M., Larsson, E., Luangsa-ard, J.J., Moreno, G., Pancorbo, F., Piątek, M., Sommai, S., Somrithipol, S., Asif, M., Delgado, G., Flakus, A., Illescas, A., Kezo, K., Khamsuntorn, P., Kubátová, A., Labuda, R., Lavoise, C., Lebel, T., Lueangjaroenkit, P., Maciá-Vicente, J.G., Paz, A., Saba, M., Shivas, R.G., Tan, Y.P., Wingfield, M.J., Aas, T., Abramczyk, B., Ainsworth, A.M., Akulov, A., Alvarado, P., Armada, F., Assyov, B., Avchar, R., Avesani, M., Bezerra, J.L., Bhat, J.D., Bilański, P., Bily, D.S., Boccardo, F., Bozok, F., Campos, J.C., Chaimongkol, S., Chellappan, N., Costa, M.M., Dalecká, M., Darmostuk, V., Daskalopoulos, V., Dearnaley, J., Dentinger, B.T.M., De Silva, N.I., Dhotre, D., Carlavilla, J.R., Doungsa-ard, C., Dovana, F., Erhard, A., Ferro, L.O., Gallegos, S.C., Giles, C.E., Gore, G., Gorfer, M., Guard, F.E., Hanson, S.-Å., Haridev, P., Jankowiak, R., Jeffers, S.N., Kandemir, H., Karich, A., Kisło, K., Kiss, L., Krisai-Greilhuber, I., Latha, K.P.D., Lorenzini, M., Lumyong, S., Manimohan, P., Manjón, J.L., Maula, F., Mazur, E., Mesquita, N.L.S., Młynek, K., Mongkolsamrit, S., Morán, P., Murugadoss, R., Nagarajan, M., Nalumpang, S., Noisripoom, W., Nosalj, S., Novaes, Q.S., Nowak, M., Pawłowska, J., Peiger, M., Pereira, O.L., Pinto, A., Plaza, M., Polemis, E., Polhorský, A., Ramos, D.O., Raza, M., Rivas-Ferreiro, M., Rodrigues-Flakus, P., Ruszkiewicz-Michalska, M., Sánchez, A., Santos, A., Schüller, A., Scott, P.A., Şen, İ, Shelke, D., Śliwa, L., Solheim, H., Sonawane, H., Strašiftáková, D., Stryjak-Bogacka, M., Sudsanguan, M., Suwannarach, N., Suz, L.M., Syme, K., Taşkın, H., Tennakoon, D.S., Tomka, P., Vaghefi, N., Vasan, V., Vauras, J., Wiktorowicz, D., Villarreal, M., Vizzini, A., Wrzosek, M., Yang, X., Yingkunchao, W., Zapparoli, G., Zervakis, G.I., and Groenewald, J.Z.

Abstract

Novel species of fungi described in this study include those from various countries as follows: Australia, Baobabopsis sabindy in leaves of Eragrostis spartinoides, Cortinarius magentiguttatus among deep leaf litter, Laurobasidium azarandamiae from uredinium of Puccinia alyxiae on Alyxia buxifolia, Marasmius pseudoelegans on well-rotted twigs and litter in mixed wet sclerophyll and subtropical rainforest. Bolivia, Favolaschia luminosa on twigs of Byttneria hirsuta, Lecanora thorstenii on bark, in savannas with shrubs and trees. Brazil, Asterina costamaiae on leaves of Rourea bahiensis, Purimyces orchidacearum (incl. Purimyces gen. nov.) as root endophyte on Cattleya locatellii. Bulgaria, Monosporascus bulgaricus and Monosporascus europaeus isolated from surface-sterilised, asymptomatic roots of Microthlaspi perfoliatum. Finland, Inocybe undatolacera on a lawn, near Betula pendula. France, Inocybe querciphila in humus of mixed forest. Germany, Arrhenia oblongispora on bare soil attached to debris of herbaceous plants and grasses. Greece, Tuber aereum under Quercus coccifera and Acer sempervirens. India, Alfoldia lenyadriensis from the gut of a Platynotus sp. beetle, Fulvifomes subramanianii on living Albizzia amara, Inosperma pavithrum on soil, Phylloporia parvateya on living Lonicera sp., Tropicoporus maritimus on living Peltophorum pterocarpum. Indonesia, Elsinoe atypica on leaf of Eucalyptus pellita. Italy, Apiotrichum vineum from grape wine, Cuphopyllus praecox among grass. Madagascar, Pisolithus madagascariensis on soil under Intsia bijuga. Netherlands, Cytosporella calamagrostidis and Periconia calamagrostidicola on old leaves of Calamagrostis arenaria, Hyaloscypha caricicola on leaves of Carex sp., Neoniesslia phragmiticola (incl. Neoniesslia gen. nov.) on leaf sheaths of standing dead culms of Phragmites australis, Neptunomyces juncicola on culms of Juncus maritimus, Zenophaeosphaeria calamagrostidis (incl. Zenophaeosphaeria gen. nov.) on culms of Calamagrost

Published
2024

6. Fungal Planet description sheets: 1550-1613.

Author

Crous, P. W., Costa, M. M., Kandemir, H., Vermaas, M., Vu, D., Zhao, L., Arumugam, E., Flakus, A., Jurjević, Ž., Kaliyaperumal, M., Mahadevakumar, S., Murugadoss, R., Shivas, R. G., Tan, Y. P., Wingfield, M. J., Abell, S. E., Marney, T. S., Danteswari, C., Darmostuk, V., and Denchev, C. M.

Subjects
DEAD trees, YEW, WHITE stork, FOREST litter, NEEM, LEAF spots
Abstract

Novel species of fungi described in this study include those from various countries as follows: Argentina, Neocamarosporium halophilum in leaf spots of Atriplex undulata. Australia, Aschersonia merianiae on scale insect (Coccoidea), Curvularia huamulaniae isolated from air, Hevansia mainiae on dead spider, Ophiocordyceps poecilometigena on Poecilometis sp. Bolivia, Lecanora menthoides on sandstone, in open semi-desert montane areas, Sticta monlueckiorum corticolous in a forest, Trichonectria epimegalosporae on apothecia of corticolous Megalospora sulphurata var. sulphurata, Trichonectria puncteliae on the thallus of Punctelia borreri. Brazil, Catenomargarita pseudocercosporicola (incl. Catenomargarita gen. nov.) hyperparasitic on Pseudocercospora fijiensis on leaves of Musa acuminata, Tulasnella restingae on protocorms and roots of Epidendrum fulgens. Bulgaria, Anthracoidea umbrosae on Carex spp. Croatia, Hymenoscyphus radicis from surface-sterilised, asymptomatic roots of Microthlaspi erraticum, Orbilia multiserpentina on wood of decorticated branches of Quercus pubescens. France, Calosporella punctatispora on dead corticated twigs of Acer opalus. French West Indies (Martinique), Eutypella lechatii on dead corticated palm stem. Germany, Arrhenia alcalinophila on loamy soil. Iceland, Cistella blauvikensis on dead grass (Poaceae). India, Fulvifomes maritimus on living Peltophorum pterocarpum, Fulvifomes natarajanii on dead wood of Prosopis juliflora, Fulvifomes subazonatus on trunk of Azadirachta indica, Macrolepiota bharadwajii on moist soil near the forest, Narcissea delicata on decaying elephant dung, Paramyrothecium indicum on living leaves of Hibiscus hispidissimus, Trichoglossum syamviswanathii on moist soil near the base of a bamboo plantation. Iran, Vacuiphoma astragalicola from stem canker of Astragalus sarcocolla. Malaysia, Neoeriomycopsis fissistigmae (incl. Neoeriomycopsidaceae fam. nov.) on leaf spots on flower Fissistigma sp. Namibia, Exophiala lichenicola lichenicolous on Acarospora cf. luederitzensis. Netherlands, Entoloma occultatum on soil, Extremus caricis on dead leaves of Carex sp., Inocybe pseudomytiliodora on loamy soil. Norway, Inocybe guldeniae on calcareous soil, Inocybe rupestroides on gravelly soil. Pakistan, Hymenagaricus brunneodiscus on soil. Philippines, Ophiocordyceps philippinensis parasitic on Asilus sp. Poland, Hawksworthiomyces ciconiae isolated from Ciconia ciconia nest, Plectosphaerella vigrensis from leaf spots on Impatiens noli-tangere, Xenoramularia epitaxicola from sooty mould community on Taxus baccata. Portugal, Inocybe dagamae on clay soil. Saudi Arabia, Diaporthe jazanensis on branches of Coffea arabica. South Africa, Alternaria moraeae on dead leaves of Moraea sp., Bonitomyces buffelskloofinus (incl. Bonitomyces gen. nov.) on dead twigs of unknown tree, Constrictochalara koukolii on living leaves of Itea rhamnoides colonised by a Meliola sp., Cylindromonium lichenophilum on Parmelina tiliacea, Gamszarella buffelskloofina (incl. Gamszarella gen. nov.) on dead insect, Isthmosporiella africana (incl. Isthmosporiella gen. nov.) on dead twigs of unknown tree, Nothoeucasphaeria buffelskloofina (incl. Nothoeucasphaeria gen. nov.), on dead twigs of unknown tree, Nothomicrothyrium beaucarneae (incl. Nothomicrothyrium gen. nov.) on dead leaves of Beaucarnea stricta, Paramycosphaerella proteae on living leaves of Protea caffra, Querciphoma foliicola on leaf litter, Rachicladosporium conostomii on dead twigs of Conostomium natalense var. glabrum, Rhamphoriopsis synnematosa on dead twig of unknown tree, Waltergamsia mpumalanga on dead leaves of unknown tree. Spain, Amanita fulvogrisea on limestone soil, in mixed forest, Amanita herculis in open Quercus forest, Vuilleminia beltraniae on Cistus symphytifolius. Sweden, Pachyella pulchella on decaying wood on sand-silt riverbank. Thailand, Deniquelata cassiae on dead stem of Cassia fistula, Stomiopeltis thailandica on dead twigs of Magnolia champaca. Ukraine, Circinaria podoliana on natural limestone outcrops, Neonematogonum carpinicola (incl. Neonematogonum gen. nov.) on dead branches of Carpinus betulus. USA, Exophiala wilsonii water from cooling tower, Hygrophorus aesculeticola on soil in mixed forest, and Neocelosporium aereum from air in a house attic. Morphological and culture characteristics are supported by DNA barcodes. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

7. Brain metabolite values in children with breath-holding spells

Author

Calik M, Sen Dokumaci D, Sarikaya S, Demir M, Isik I, Kazanasmaz H, Kaya C, and Kandemir H

Subjects
breath-holding spells, neuronal damage, children, magnetic resonance spectroscopy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Mustafa Calik,1 Dilek Sen Dokumaci,2 Suna Sarikaya,3 Mahmut Demir,4 Ilhan Isik,5 Halil Kazanasmaz,4 Cemil Kaya,4 Hasan Kandemir6 1Department of Pediatric Neurology, 2Department of Radiology, 3Department of Neurology, 4Department of Pediatrics, Harran University School of Medicine, 5Department of Pediatric Neurology, Eyyubiye Training and Research Hospital, 6Department of Child and Adolescent Psychiatry, Harran University School of Medicine, Sanliurfa, Turkey Abstract: Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells. Keywords: brain metabolite, children, breath holding, magnetic resonance spectroscopy

Published
2017

8. Fungal planet description sheets : 1550-1613

Author

Crous, P.W., Costa, M.M., Kandemir, H., Vermaas, M., Vu, D., Zhao, L., Arumugam, E., Flakus, A., Jurjević, Kaliyaperumal, M., Mahadevakumar, S., Murugadoss, R., Shivas, R.G., Tan, Y.P., Wingfield, M.J., Abell, S.E., Marney, T.S., Danteswari, C., Darmostuk, V., Denchev, C.M., Denchev, T.T., Etayo, J., Gené, J., Gunaseelan, S., Hubka, V., Illescas, T., Jansen, G.M., Kezo, K., Kumar, S., Larsson, E., Mufeeda, K.T., Piątek, M., Rodriguez-Flakus, P., Sarma, P., Stryjak-Bogacka, M., Torres-Garcia, D., Vauras, J., Acal, D.A., Akulov, A., Alhudaib, K., Asif, M., Balashov, S., Baral, H.O., Baturo-Cieśniewska, A., Begerow, D., Beja-Pereira, A., Bianchinotti, M.V., Bilański, P., Chandranayaka, S., Chellappan, N., Cowan, D.A., Custódio, F.A., Czachura, P., Delgado, G., De Silva, N.I., Dijksterhuis, J., Duenas, M., Eisvand, P., Fachada, V., Fournier, J., Fritsche, Y., Fuljer, F., Ganga, K.G.G., Guerra, M.P., Hansen, K., Hywel-Jones, N., Ismail, A.M., Jacobs, C.R., Jankowiak, R., Karich, A., Kemler, M., Kisło, K., Klofac, W., Krisai-Greilhuber, I., Latha, K.P.D., Lebeuf, R., Lopes, M.E., Lumyong, S., Maciá-Vicente, J.G., Maggs-Kölling, G., Magistà, D., Manimohan, P., Martín, M.P., Mazur, E., Mehrabi-Koushki, M., Miller, A.N., Mombert, A., Ossowska, E.A., Patejuk, K., Pereira, O.L., Piskorski, S., Plaza, M., Podile, A.R., Polhorsky, A., Pusz, W., Raza, M., Ruszkiewicz-Michalska, M., Saba, M., Sánchez, R.M., Singh, R., Śliwa, L., Smith, M.E., Stefenon, V.M., Strasiftáková, D., Suwannarach, N., Szczepańska, K., Telleria, M.T., Tennakoon, D.S., Thines, M., Thorn, R.G., Urbaniak, J., van der Vegte, M., Vasan, V., Vila-Viçosa, C., Voglmayr, H., Wrzosek, M., Zappelini, J., Groenewald, J.Z., Crous, P.W., Costa, M.M., Kandemir, H., Vermaas, M., Vu, D., Zhao, L., Arumugam, E., Flakus, A., Jurjević, Kaliyaperumal, M., Mahadevakumar, S., Murugadoss, R., Shivas, R.G., Tan, Y.P., Wingfield, M.J., Abell, S.E., Marney, T.S., Danteswari, C., Darmostuk, V., Denchev, C.M., Denchev, T.T., Etayo, J., Gené, J., Gunaseelan, S., Hubka, V., Illescas, T., Jansen, G.M., Kezo, K., Kumar, S., Larsson, E., Mufeeda, K.T., Piątek, M., Rodriguez-Flakus, P., Sarma, P., Stryjak-Bogacka, M., Torres-Garcia, D., Vauras, J., Acal, D.A., Akulov, A., Alhudaib, K., Asif, M., Balashov, S., Baral, H.O., Baturo-Cieśniewska, A., Begerow, D., Beja-Pereira, A., Bianchinotti, M.V., Bilański, P., Chandranayaka, S., Chellappan, N., Cowan, D.A., Custódio, F.A., Czachura, P., Delgado, G., De Silva, N.I., Dijksterhuis, J., Duenas, M., Eisvand, P., Fachada, V., Fournier, J., Fritsche, Y., Fuljer, F., Ganga, K.G.G., Guerra, M.P., Hansen, K., Hywel-Jones, N., Ismail, A.M., Jacobs, C.R., Jankowiak, R., Karich, A., Kemler, M., Kisło, K., Klofac, W., Krisai-Greilhuber, I., Latha, K.P.D., Lebeuf, R., Lopes, M.E., Lumyong, S., Maciá-Vicente, J.G., Maggs-Kölling, G., Magistà, D., Manimohan, P., Martín, M.P., Mazur, E., Mehrabi-Koushki, M., Miller, A.N., Mombert, A., Ossowska, E.A., Patejuk, K., Pereira, O.L., Piskorski, S., Plaza, M., Podile, A.R., Polhorsky, A., Pusz, W., Raza, M., Ruszkiewicz-Michalska, M., Saba, M., Sánchez, R.M., Singh, R., Śliwa, L., Smith, M.E., Stefenon, V.M., Strasiftáková, D., Suwannarach, N., Szczepańska, K., Telleria, M.T., Tennakoon, D.S., Thines, M., Thorn, R.G., Urbaniak, J., van der Vegte, M., Vasan, V., Vila-Viçosa, C., Voglmayr, H., Wrzosek, M., Zappelini, J., and Groenewald, J.Z.

Abstract

Novel species of fungi described in this study include those from various countries as follows: Argentina, Neocamarosporium halophilum in leaf spots of Atriplex undulata. Australia, Aschersonia merianiae on scale insect (Coccoidea), Curvularia huamulaniae isolated from air, Hevansia mainiae on dead spider, Ophiocordyceps poecilometigena on Poecilometis sp. Bolivia, Lecanora menthoides on sandstone, in open semi-desert montane areas, Sticta monlueckiorum corticolous in a forest, Trichonectria epimegalosporae on apothecia of corticolous Mega- lospora sulphurata var. sulphurata, Trichonectria puncteliae on the thallus of Punctelia borreri. Brazil, Catenomargarita pseudocercosporicola (incl. Catenomargarita gen. nov.) hyperparasitic on Pseudocercospora fijiensis on leaves of Musa acuminata, Tulasnella restingae on protocorms and roots of Epidendrum fulgens. Bulgaria, Anthracoidea umbrosae on Carex spp. Croatia, Hymenoscyphus radicis from surface-sterilised, asymptomatic roots of Microthlaspi erraticum, Orbilia multiserpentina on wood of decorticated branches of Quercus pubescens. France, Calosporella punctatispora on dead corticated twigs of Acer opalus. French West Indies (Martinique), Eutypella lechatii on dead corticated palm stem. Germany, Arrhenia alcalinophila on loamy soil. Iceland, Cistella blauvikensis on dead grass (Poaceae). India, Fulvifomes maritimus on living Peltophorum pterocarpum, Fulvifomes natarajanii on dead wood of Prosopis juliflora, Fulvifomes subazonatus on trunk of Azadirachta indica, Macrolepiota bharadwajii on moist soil near the forest, Narcissea delicata on decaying elephant dung, Paramyrothecium indicum on living leaves of Hibiscus hispidissimus, Trichoglossum syamviswanathii on moist soil near the base of a bamboo plantation. Iran, Vacuiphoma astragalicola from stem canker of Astragalus sarcocolla. Malaysia, Neoeriomycopsis fissistigmae (incl. Neoeriomycopsidaceae fam. nov.) on leaf spots on flower Fissistigma sp. Namibia, Exophiala lichen

Published
2023

9. Fungal Planet description sheets: 1550–1613

Author

Crous, P.W. (Pedro Willem), Costa, M.M., Kandemir, H., Vermaas, M., Vu, D., Zhao, L., Arumugam, E., Flakus, A., Jurjević, Ž., Kaliyaperumal, M., Mahadevakumar, S., Murugadoss, R., Shivas, R.G., Tan, Y.P., Wingfield, M.J., Abell, S.E., Marney, T.S., Danteswari, C., Darmostuk, V., Denchev, C.M., Denchev, T.T., Etayo, J., Gené, J., Gunaseelan, S., Hubka, V., Illescas, T., Jansen, G.M. (Gerrit), Kezo, K., Kumar, S., Larsson, E., Mufeeda, K.T., Pitek, M., Rodriguez-Flakus, P., Sarma, P.V.S.R.N., Stryjak-Bogacka, M., Torres-Garcia, D., Vauras, J., Acal, D.A., Akulov, A., Alhudaib, K., Asif, M., Balashov, S., Baral, H.-O., Baturo-Cieniewska, A., Begerow, D., Beja-Pereira, A., Bianchinotti, M.V., Bilaski, P., Chandranayaka, S., Chellappan, N., Cowan, D.A., Custódio, F.A., Czachura, P., Delgado, G., Desilva, N.I., Dijksterhuis, J., Dueñas, M., Eisvand, P., Fachada, V., Fournier, J., Fritsche, Y., Fuljer, F., Ganga, K.G.G., Guerra, M.P., Hansen, K., Hywel-Jones, N., Ismail, A.M., Jacobs, C.R., Jankowiak, R., Karich, A., Kemler, M., Kisło, K., Klofac, W., Krisai-Greilhuber, I., Latha, K.P.D., Lebeuf, R., Lopes, M.E., Lumyong, S., Maciá-Vicente, J.G., Maggs-Kölling, G., Magistà, D., Manimohan, P., Martín, M.P., Mazur, E., Mehrabi-Koushki, M., Miller, A.N., Mombert, A., Ossowska, E.A., Patejuk, K., Pereira, O.L., Piskorski, S., Plaza, M., Podile, A.R., Polhorský, A., Pusz, W., Raza, M., Ruszkiewicz-Michalska, M., Saba, M., Sánchez, R.M., Singh, R., Liwa, L, Smith, M.E., Stefenon, V.M., Strašiftáková, D., Suwannarach, N., Szczepaska, K., Telleria, M.T., Tennakoon, D.S., Thines, M., Thorn, R.G., Urbaniak, J., Vandervegte, M., Vasan, V., Vila-Viçosa, C., Voglmayr, H., Wrzosek, M., Zappelini, J., Groenewald, J.Z., Crous, P.W. (Pedro Willem), Costa, M.M., Kandemir, H., Vermaas, M., Vu, D., Zhao, L., Arumugam, E., Flakus, A., Jurjević, Ž., Kaliyaperumal, M., Mahadevakumar, S., Murugadoss, R., Shivas, R.G., Tan, Y.P., Wingfield, M.J., Abell, S.E., Marney, T.S., Danteswari, C., Darmostuk, V., Denchev, C.M., Denchev, T.T., Etayo, J., Gené, J., Gunaseelan, S., Hubka, V., Illescas, T., Jansen, G.M. (Gerrit), Kezo, K., Kumar, S., Larsson, E., Mufeeda, K.T., Pitek, M., Rodriguez-Flakus, P., Sarma, P.V.S.R.N., Stryjak-Bogacka, M., Torres-Garcia, D., Vauras, J., Acal, D.A., Akulov, A., Alhudaib, K., Asif, M., Balashov, S., Baral, H.-O., Baturo-Cieniewska, A., Begerow, D., Beja-Pereira, A., Bianchinotti, M.V., Bilaski, P., Chandranayaka, S., Chellappan, N., Cowan, D.A., Custódio, F.A., Czachura, P., Delgado, G., Desilva, N.I., Dijksterhuis, J., Dueñas, M., Eisvand, P., Fachada, V., Fournier, J., Fritsche, Y., Fuljer, F., Ganga, K.G.G., Guerra, M.P., Hansen, K., Hywel-Jones, N., Ismail, A.M., Jacobs, C.R., Jankowiak, R., Karich, A., Kemler, M., Kisło, K., Klofac, W., Krisai-Greilhuber, I., Latha, K.P.D., Lebeuf, R., Lopes, M.E., Lumyong, S., Maciá-Vicente, J.G., Maggs-Kölling, G., Magistà, D., Manimohan, P., Martín, M.P., Mazur, E., Mehrabi-Koushki, M., Miller, A.N., Mombert, A., Ossowska, E.A., Patejuk, K., Pereira, O.L., Piskorski, S., Plaza, M., Podile, A.R., Polhorský, A., Pusz, W., Raza, M., Ruszkiewicz-Michalska, M., Saba, M., Sánchez, R.M., Singh, R., Liwa, L, Smith, M.E., Stefenon, V.M., Strašiftáková, D., Suwannarach, N., Szczepaska, K., Telleria, M.T., Tennakoon, D.S., Thines, M., Thorn, R.G., Urbaniak, J., Vandervegte, M., Vasan, V., Vila-Viçosa, C., Voglmayr, H., Wrzosek, M., Zappelini, J., and Groenewald, J.Z.

Abstract

Novel species of fungi described in this study include those from various countries as follows: Argentina, Neocamarosporium halophilum in leaf spots of Atriplex undulata. Australia, Aschersonia merianiae on scale insect (Coccoidea), Curvularia huamulaniae isolated from air, Hevansia mainiae on dead spider, Ophiocordyceps poecilometigena on Poecilometis sp. Bolivia, Lecanora menthoides on sandstone, in open semi-desert montane areas, Sticta monlueckiorum corticolous in a forest, Trichonectria epimegalosporae on apothecia of corticolous Megalospora sulphurata var. sulphurata, Trichonectria puncteliae on the thallus of Punctelia borreri. Brazil, Catenomargarita pseudocercosporicola (incl. Catenomargarita gen. nov.) hyperparasitic on Pseudocercospora fijiensis on leaves of Musa acuminata, Tulasnella restingae on protocorms and roots of Epidendrum fulgens. Bulgaria, Anthracoidea umbrosae on Carex spp. Croatia, Hymenoscyphus radicis from surface-sterilised, asymptomatic roots of Microthlaspi erraticum, Orbilia multiserpentina on wood of decorticated branches of Quercus pubescens. France, Calosporella punctatispora on dead corticated twigs of Acer opalus. French West Indies (Martinique), Eutypella lechatii on dead corticated palm stem. Germany, Arrhenia alcalinophila on loamy soil. Iceland, Cistella blauvikensis on dead grass (Poaceae). India, Fulvifomes maritimus on living Peltophorum pterocarpum, Fulvifomes natarajanii on dead wood of Prosopis juliflora, Fulvifomes subazonatus on trunk of Azadirachta indica, Macrolepiota bharadwajii on moist soil near the forest, Narcissea delicata on decaying elephant dung, Paramyrothecium indicum on living leaves of Hibiscus hispidissimus, Trichoglossum syamviswanathii on moist soil near the base of a bamboo plantation. Iran, Vacuiphoma astragalicola from stem canker of Astragalus sarcocolla. Malaysia, Neoeriomycopsis fissistigmae (incl. Neoeriomycopsidaceae fam. nov.) on leaf spots on flower Fissistigma sp. Namibia, Exophiala lichenic

Published
2023
Full Text
View/download PDF

10. Microribonucleic acid dysregulations in children and adolescents with obsessive–compulsive disorder

Author

Kandemir H, Erdal ME, Selek S, İzci Ay Ö, Karababa İF, Ay ME, Kandemir SB, Yılmaz ŞG, Ekinci S, Taşdelen B, and Bayazit H

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Hasan Kandemir,1 Mehmet Emin Erdal,2 Salih Selek,3 Özlem İzci Ay,2 İbrahim Fatih Karababa,4 Mustafa Ertan Ay,2 Sultan Basmaci Kandemir,5 Şenay Görücü Yılmaz,2 Suat Ekinci,6 Bahar Taşdelen,7 Hüseyin Bayazit41Department of Child and Adolescent Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey; 2Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey; 3Harris County Psychiatric Center, University of Texas Health Science Center at Houston, TX, USA; 4Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey; 5Department of Psychiatry, Balikligöl State Hospital, Sanliurfa, Turkey; 6Department of Psychiatry, Balikli Rum Hospital, Istanbul, Turkey; 7Department of Biostatistics, Faculty of Medicine, Mersin University, Mersin, TurkeyAim: Obsessive–compulsive disorder (OCD) is a disorder characterized by the presence of obsessions and/or compulsions. Although disorder etiology and pathogenesis remains unknown, several theories about OCD development have been proposed, and many researchers believe that it is caused by both genetic and environmental factors. In the current study, our aim was to investigate miRNA levels in OCD.Methods: In the current study, we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p, and miR155a-5p levels in child and adolescent OCD patients. The research sample consisted of a group of 23 OCD patients and 40 healthy volunteer controls.Results: There was no significant difference in age and sex between the two groups (P>0.05).The levels of miR22-3p, miR24-3p, miR106b-5p, miR125b-5p, and miR155a-5p were significantly increased in the OCD subjects (P≤0.05). There were no statistically significant differences in miR18a-5p or miR107 levels between groups (P≥0.05).Conclusion: There could be a close relationship between levels of circulating miRNAs and OCD. If we could understand how the signaling pathways arranged by miRNAs impact on central nervous system development, function, and pathology, this understanding could improve our knowledge about OCD etiology and treatment.Keywords: OCD, micro RNA, miRNA, psychiatry, child psychiatry

Published
2015

11. Validity and reliability of the Turkish version of CRAFFT Substance Abuse Screening Test among adolescents

Author

Kandemir H, Aydemir Ö, Ekinci S, Selek S, Kandemir SB, and Bayazit H

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Hasan Kandemir,1 Ömer Aydemir,2 Suat Ekinci,3 Salih Selek,4 Sultan B Kandemir,5 Hüseyin Bayazit61Department of Child and Adolescent Psychiatry, School of Medicine, Harran University, Sanliurfa, 2Department of Psychiatry, School of Medicine, Celal Bayar University, Manisa, 3Balikli Rum Hospital, Istanbul, 4Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas, USA; 5Department of Psychiatry, Balikligol State Hospital, Sanliurfa, 6Department of Psychiatry, School of Medicine, Harran University, Sanliurfa, TurkeyAim: This study aimed to validate the CRAFFT diagnostic test, against the Diagnostic and Statistical Manual of Mental Disorders – Fourth Edition, Axis 1-based diagnostic inventory in a Turkish population of adolescents.Method: The 124 adolescents who were 15–18 years old were enrolled to this study. CRAFFT was self-administered. Interviews took approximately 30 minutes, including the DSM-IV diagnostic interview for alcohol/drug dependence.Results: The mean age of subjects was 16.653 years (minimum: 15 years, maximum: 18 years). A score of 2 or higher in part B was found to be optimal for detecting youths with substance dependence problems (sensitivity: 0.82; specificity: 0.88) and it was sufficiently discriminative.Conclusion: The CRAFFT is a valid and reliable instrument for identifying Turkish-speaking youths at risk for substance use disorders.Keywords: CRAFFT, substance abuse, validity, Turkish, adolescent

Published
2015

12. Fusariumand Allied Fusarioid Taxa (FUSA). 1

Author

Crous, P.W., primary, Sandoval-Denis, M., additional, Costa, M.M., additional, Groenewald, J.Z., additional, van Iperen, A.L., additional, Starink-Willemse, M., additional, Hernández-Restrepo, M., additional, Kandemir, H., additional, Ulaszewski, B., additional, de Boer, W., additional, Abdel-Azeem, A.M., additional, Abdollahzadeh, J., additional, Akulov, A., additional, Bakhshi, M., additional, Bezerra, J.D.P., additional, Bhunjun, C.S., additional, Câmara, M.P.S., additional, Chaverri, P., additional, Vieira, W.A.S., additional, Decock, C.A., additional, Gaya, E., additional, Gené, J., additional, Guarro, J., additional, Gramaje, D., additional, Grube, M., additional, Gupta, V.K., additional, Guarnaccia, V., additional, Hill, R., additional, Hirooka, Y., additional, Hyde, K.D., additional, Jayawardena, R.S., additional, Jeewon, R., additional, Jurjević, Ž., additional, Korsten, L., additional, Lamprecht, S.C., additional, Lombard, L., additional, Maharachchikumbura, S.S.N., additional, Polizzi, G., additional, Rajeshkumar, K.C., additional, Salgado-Salazar, C., additional, Shang, Q.J., additional, Shivas, R.G., additional, Summerbell, R.C., additional, Sun, G.Y., additional, Swart, W.J., additional, Tan, Y.P., additional, Vizzini, A., additional, Xia, J.W., additional, Zare, R., additional, González, C.D., additional, Iturriaga, T., additional, Savary, O., additional, Coton, M., additional, Coton, E., additional, Jany, J.L., additional, Liu, C., additional, Zeng, Z.Q., additional, Zhuang, W.Y., additional, Yu, Z.H., additional, and Thines, M., additional

Published
2022
Full Text
View/download PDF

13. Fusarium and allied fusarioid taxa (FUSA). 1

Author

Crous, P.W., Sandoval-Denis, M., Groenewald, J.Z., Costa, M.M., van Iperen, A.L., Starink-Willemse, M., Hernández-Restrepo, M., Kandemir, H., Ulaszewski, B., de Boer, W., Abdel-Azeem, A.M., Abdollahzadeh, J., Akulov, A., Bakhshi, M., Bezerra, J.D.P., Bhunjun, C.S., Câmara, M.P.S., Chaverri, P., Vieira, W.A.S., Decock, C.A., Gaya, E., Gené, J., Guarro, J., Gramaje, D., Grube, M., Gupta, V.K., Guarnaccia, V., Hill, R., Hirooka, Y., Hyde, K.D., Jayawardena, R.S., Jeewon, R., Jurjević, Ž, Korsten, L., Lamprecht, S.C., Lombard, L., Maharachchikumbura, S.S.N., Polizzi, G., Rajeshkumar, K.C., Salgado-Salazar, C., Shang, Q.-J., Shivas, R.G., Summerbell, R.C., Sun, G.Y., Swart, W.J., Tan, Y.P., Vizzini, A., Xia, J.W., Zare, R., González, C.D., Iturriaga, T., Savary, O., Coton, M., Coton, E., Jany, J.-L., Liu, C., Zeng, Z.-Q., Zhuang, W.-Y., Yu, Z.-H., Thines, M., Crous, P.W., Sandoval-Denis, M., Groenewald, J.Z., Costa, M.M., van Iperen, A.L., Starink-Willemse, M., Hernández-Restrepo, M., Kandemir, H., Ulaszewski, B., de Boer, W., Abdel-Azeem, A.M., Abdollahzadeh, J., Akulov, A., Bakhshi, M., Bezerra, J.D.P., Bhunjun, C.S., Câmara, M.P.S., Chaverri, P., Vieira, W.A.S., Decock, C.A., Gaya, E., Gené, J., Guarro, J., Gramaje, D., Grube, M., Gupta, V.K., Guarnaccia, V., Hill, R., Hirooka, Y., Hyde, K.D., Jayawardena, R.S., Jeewon, R., Jurjević, Ž, Korsten, L., Lamprecht, S.C., Lombard, L., Maharachchikumbura, S.S.N., Polizzi, G., Rajeshkumar, K.C., Salgado-Salazar, C., Shang, Q.-J., Shivas, R.G., Summerbell, R.C., Sun, G.Y., Swart, W.J., Tan, Y.P., Vizzini, A., Xia, J.W., Zare, R., González, C.D., Iturriaga, T., Savary, O., Coton, M., Coton, E., Jany, J.-L., Liu, C., Zeng, Z.-Q., Zhuang, W.-Y., Yu, Z.-H., and Thines, M.

Abstract

Seven Fusarium species complexes are treated, namely F. aywerte species complex (FASC) (two species), F. buharicum species complex (FBSC) (five species), F. burgessii species complex (FBURSC) (three species), F. camptoceras species complex (FCAMSC) (three species), F. chlamydosporum species complex (FCSC) (eight species), F. citricola species complex (FCCSC) (five species) and the F. concolor species complex (FCOSC) (four species). New species include Fusicolla elongata from soil (Zimbabwe), and Neocosmospora geoasparagicola from soil associated with Asparagus officinalis (Netherlands). New combinations include Neocosmospora akasia, N. awan, N. drepaniformis, N. duplosperma, N. geoasparagicola, N. mekan, N. papillata, N. variasi and N. warna. Newly validated taxa include Longinectria gen. nov., L. lagenoides, L. verticilliforme, Fusicolla gigas and Fusicolla guangxiensis. Furthermore, Fusarium rosicola is reduced to synonymy under N. brevis. Finally, the genome assemblies of Fusicolla betae (CBS 175.32), Microcera coccophila (CBS 310.34), Rectifusarium robinianum (CBS 430.91), Rugonectria rugulosa (CBS 126565), and Thelonectria blattea (CBS 952.68) are also announced here.

Published
2022

14. Fusarium and allied fusarioid taxa (FUSA). 1

Author

Crous, P. W., Sandoval-Denis, M., Costa, M. M., Groenewald, J. Z., Iperen, A. L. van, Starink-Willemse, M., Hernández-Restrepo, Margarita, Kandemir, H., Ulaszewski, B., Boer, W. de, Abdel-Azeem, A. M., Abdollahzadeh, J., Akulov, A., Bakhshi, Mounes, Bezerra, J. D. P., Bhunjun, C.S., Câmara, M. P. S., Chaverri, Priscila, Vieira, Willie A. S., Decock, Cony A., Gaya, Ester, Gené, J., Guarro, J., Gramaje, David, Grube, Martin, Gupta, Vijai Kumar, Guarnaccia, Vladimiro, Hill, R., Hirooka, Y., Hyde, K. D., Jayawardena, R. S., Jeewon, Rajesh, Jurjević, Željko, Korsten, L., Lamprecht, Sandra Christina, Lombard, L., Maharachchikumbura, Sajeewa S. N., Polizzi, Giancarlo, Rajeshkumar, Kunhiraman C., Salgado-Salazar, Catalina, Shang, Q. J., Shivas, R. G., Summerbell, Richard C., Sun, G. Y., Swart, Wijnand J., Tan, Y. P., Vizzini, Alfredo, Xia, J. W., Zare, Rasoul, Crous, P. W., Sandoval-Denis, M., Costa, M. M., Groenewald, J. Z., Iperen, A. L. van, Starink-Willemse, M., Hernández-Restrepo, Margarita, Kandemir, H., Ulaszewski, B., Boer, W. de, Abdel-Azeem, A. M., Abdollahzadeh, J., Akulov, A., Bakhshi, Mounes, Bezerra, J. D. P., Bhunjun, C.S., Câmara, M. P. S., Chaverri, Priscila, Vieira, Willie A. S., Decock, Cony A., Gaya, Ester, Gené, J., Guarro, J., Gramaje, David, Grube, Martin, Gupta, Vijai Kumar, Guarnaccia, Vladimiro, Hill, R., Hirooka, Y., Hyde, K. D., Jayawardena, R. S., Jeewon, Rajesh, Jurjević, Željko, Korsten, L., Lamprecht, Sandra Christina, Lombard, L., Maharachchikumbura, Sajeewa S. N., Polizzi, Giancarlo, Rajeshkumar, Kunhiraman C., Salgado-Salazar, Catalina, Shang, Q. J., Shivas, R. G., Summerbell, Richard C., Sun, G. Y., Swart, Wijnand J., Tan, Y. P., Vizzini, Alfredo, Xia, J. W., and Zare, Rasoul

Abstract

Seven Fusarium species complexes are treated, namely F. aywerte species complex (FASC) (two species), F. buharicum species complex (FBSC) (five species), F. burgessii species complex (FBURSC) (three species), F. camptoceras species complex (FCAMSC) (three species), F. chlamydosporum species complex (FCSC) (eight species), F. citricola species complex (FCCSC) (five species) and the F. concolor species complex (FCOSC) (four species). New species include Fusicolla elongata from soil (Zimbabwe), and Neocosmospora geoasparagicola from soil associated with Asparagus officinalis (Netherlands). New combinations include Neocosmospora akasia, N. awan, N. drepaniformis, N. duplosperma, N. geoasparagicola, N. mekan, N. papillata, N. variasi and N. warna. Newly validated taxa include Longinectria gen. nov., L. lagenoides, L. verticilliforme, Fusicolla gigas and Fusicolla guangxiensis. Furthermore, Fusarium rosicola is reduced to synonymy under N. brevis. Finally, the genome assemblies of Fusarium secorum (CBS 175.32), Microcera coccophila (CBS 310.34), Rectifusarium robinianum (CBS 430.91), Rugonectria rugulosa (CBS 126565), and Thelonectria blattea (CBS 952.68) are also announced here

Published
2022

15. Fusarium and allied fusarioid taxa (FUSA). 1

Author

Universitat Rovira i Virgili, Crous PW; Sandoval-Denis M; Costa MM; Groenewald JZ; van Iperen AL; Starink-Willemse M; Hernandez-Restrepo M; Kandemir H; Ulaszewski B; de Boer W; Abdel-Azeem AM; Abdollahzadeh J; Akulov A; Bakhshi M; Bezerra JDP; Bhunjun CS; Camara MPS; Chaverri P; Vieira WAS; Decock CA; Gaya E; Gene J; Guarro J; Gramaje D; Grube M; Gupta VK; Guarnaccia V; Hill R; Hirooka Y; Hyde KD; Jayawardena RS; Jeewon R; Jurjevic Z; Korsten L; Lamprecht SC; Lombard L; Maharachchikumbura SSN; Polizzi G; Rajeshkumar KC; Salgado-Salazar C; Shang QJ; Shivas RG; Summerbell RC; Sun GY; Swart WJ; Tan YP; Vizzini A; Xia JW; Zare R; Gonzalez CD; Iturriaga T; Savary O; Coton M; Coton E; Jany JL; Liu C; Zeng ZQ; Zhuang WY; Yu ZH; Thines M, Universitat Rovira i Virgili, and Crous PW; Sandoval-Denis M; Costa MM; Groenewald JZ; van Iperen AL; Starink-Willemse M; Hernandez-Restrepo M; Kandemir H; Ulaszewski B; de Boer W; Abdel-Azeem AM; Abdollahzadeh J; Akulov A; Bakhshi M; Bezerra JDP; Bhunjun CS; Camara MPS; Chaverri P; Vieira WAS; Decock CA; Gaya E; Gene J; Guarro J; Gramaje D; Grube M; Gupta VK; Guarnaccia V; Hill R; Hirooka Y; Hyde KD; Jayawardena RS; Jeewon R; Jurjevic Z; Korsten L; Lamprecht SC; Lombard L; Maharachchikumbura SSN; Polizzi G; Rajeshkumar KC; Salgado-Salazar C; Shang QJ; Shivas RG; Summerbell RC; Sun GY; Swart WJ; Tan YP; Vizzini A; Xia JW; Zare R; Gonzalez CD; Iturriaga T; Savary O; Coton M; Coton E; Jany JL; Liu C; Zeng ZQ; Zhuang WY; Yu ZH; Thines M

Abstract

Seven Fusarium species complexes are treated, namely F. aywerte species complex (FASC) (two species), F. buharicum species complex (FBSC) (five species), F. burgessii species complex (FBURSC) (three species), F. camptoceras species complex (FCAMSC) (three species), F. chlamydosporum species complex (FCSC) (eight species), F. citricola species complex (FCCSC) (five species) and the F. concolor species complex (FCOSC) (four species). New species include Fusicolla elongata from soil (Zimbabwe), and Neocosmospora geoasparagicola from soil associated with Asparagus officinalis (Netherlands). New combinations include Neocosmospora akasia, N. awan, N. drepaniformis, N. duplosperma, N. geoasparagicola, N. mekan, N. papillata, N. variasi and N. warna. Newly validated taxa include Longinectria gen. nov., L. lagenoides, L. verticilliforme, Fusicolla gigas and Fusicolla guangxiensis. Furthermore, Fusarium rosicola is reduced to synonymy under N. brevis. Finally, the genome assemblies of Fusarium secorum (CBS 175.32), Microcera coccophila (CBS 310.34), Rectifusarium robinianum (CBS 430.91), Rugonectria rugulosa (CBS 126565), and Thelonectria blattea (CBS 952.68) are also announced here

Published
2022

16. Psychiatric comorbidity distribution and diversities in children and adolescents with attention deficit/hyperactivity disorder: a study from Turkey

Author

Yüce M, Zoroglu SS, Ceylan MF, Kandemir H, and Karabekiroglu K

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Murat Yüce,1 Süleyman Salih Zoroglu,2 Mehmet Fatih Ceylan,3 Hasan Kandemir,4 Koray Karabekiroglu5 1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey; 2Department of Child and Adolescent Psychiatry, Medical Faculty of Istanbul, Istanbul University, Istanbul, Turkey; 3Department of Child and Adolescent Psychiatry, Dr Sami Ulus Children's Hospital, Ankara, Turkey; 4Department of Child and Adolescent Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey; 5Department of Child and Adolescent Psychiatry, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey Objective: We aimed to determine distribution and diversities of psychiatric comorbidities in children and adolescents with attention deficit/hyperactivity disorder (ADHD) in terms of age groups, sex, and ADHD subtype. Materials and methods: The sample included 6–18 year old children and adolescents from Turkey (N=108; 83 boys, 25 girls) diagnosed with ADHD. All comorbid diagnoses were determined based on the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version assessment. Results: 96.3% of the cases were found to have at least one psychiatric comorbid diagnosis. The most frequent psychiatric comorbid disorder was oppositional defiant disorder (69.4%) followed by anxiety disorders (49%) and elimination disorders (27.8%). Disruptive behavior disorders were more common in ADHD-combined type. Depression and anxiety disorders were more common in girls. Separation anxiety disorder and elimination disorder were more common in children, whereas depression, bipolar disorder, obsessive–compulsive disorder, and social phobia were more common in the adolescents. Conclusion: According to our results, when a diagnostic tool was used to assess the presence of comorbid psychiatric disorders in children and adolescents diagnosed with ADHD, almost all cases had at least one comorbid diagnosis. Therefore, especially in the clinical sample, ADHD cases should not be solely interpreted with ADHD symptom domains, instead they should be investigated properly in terms of accompanying psychiatric disorders. Keywords: attention deficit/hyperactivity disorder, psychiatric comorbidity, child, adolescent

Published
2013

18. Could neutrophil-to-lymphocyte ratio be an important parameter in children and adolescents with obsessive compulsive disorder? [Çocuk ve ergen obsesif kompulsif bozukluk tanılı hastalarda nötrofil lenfosit oranı önemli bir parametre olabilir mi?]

Author

Uzun, A.D. and Sapmaz, Ş.Y. and Çakır, B. and Kandemir, H. and Department of Child and Adolescent Psychiatry, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey

Subjects
mental disorders, fungi, behavioral disciplines and activities, humanities
Abstract

Objective: The number of studies that suggest the possible role of immune abnormalities in the pathogenesis of obsessive-compulsive disorder(OCD) are increasing. Our aim here is to determine the relationship between neutrophil lymphocyte ratio(NLR) and children and adolescents with OCD.NLR and platelet lymphocyte ratio(PLR) are new, inexpensive, easily reproducible indicators used for the determination of low grade inflammation. Method: In this study, retrospective records of 32 children and adolescents with OCD were screened, and the NLR, PLR,monocyte lymphocyte ratio (MLR) data obtained from the pre-treatment complete blood count were compared with the same data of the healthy control group with similar characteristics. Results: The NLR was found lower in children and adolescents with OCD compared to the control group; yet PLR and MLR were not significantly different. Discussion: Inflammation might play a role in the etiopahogenesis of OCD. The NLR may be potential inlammation markers for OCD in children. © 2020 ANP Publishing. All rights reserved.

Published
2020

19. study from Turkey

Author

Kutuk, MO, Tufan, E, Gokcen, C, Kilicaslan, F, Karadag, M, Mutluer, T, Yektas, C, Coban, N, Kandemir, H, Buber, A, Coskun, S, Acikbas, U, Guler, G, Topal, Z, Celik, F, Altintas, E, Giray, A, Aka, Y, and Kutuk, O

Subjects
Autism Spectrum Disorder, Cytokines, Immune system, Inflammation
Abstract

ERRATIONS; RECEPTORS; RISK; CNS Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction as well as restricted interests and repetitive behaviors. The pathogenesis of ASD is not completely understood, but a growing body of research has demonstrated that the immune response may be a contributing factor in the etiology and/or ontogeny of ASD. The aim of this study was to determine the expression levels of IL-1 beta, IL-1 alpha, IL-4, IL-6, IL-17, TNF-alpha and TGF-beta in peripheral blood mononuclear cells of children with ASD and healthy controls in order to determine the contributions of cytokines to ASD. Within the study timeframe, 195 children with ASDs (80.5% male) and 162 controls (73.6% male) were enrolled. Most children with ASD had a comorbid disorder (n = 114, 58.5%), with the most common diagnoses as Intellectual Developmental Disorder (IDD, n = 64, 32.8%) and ADHD (n = 64, 32.8%). The majority of children with ASD had severe autistic symptoms as evaluated via Childhood Autism Rating Scale (CARS, n = 130, 64.6%). The mean CARS score in the ASD sample was 40.8 (S.D. = 7.6). The patients with ASD were found to have significantly higher levels of IL-6 (p < 0.001) and significantly lower levels of IL-17 (p < 0.05, all Bonferroni corrected). Treatment tended to affect IL-4 levels. Lastly, discriminant function analysis (DFA) revealed that a combination of IL-6, IL-17 and IL-1 alpha correctly classified 56.6% of cases. Despite extensive immunological evidence suggesting immune system aberrations, further research is required to clarify the relationship between immune profiles and ASD symptoms. C1 [Kutuk, Meryem Ozlem] Baskent Univ, Dr Turgut Noyan Med & Res Ctr, Dept Child & Adolescent Psychiat, Adana, Turkey. [Tufan, Evren] Acibadem Mehmet Ali Aydinlar Univ, Dept Child & Adolescent Psychiat, Istanbul, Turkey. [Gokcen, Cem; Topal, Zehra] Gaziantep Univ, Dept Child & Adolescent Psychiat, Gaziantep, Turkey. [Kilicaslan, Fethiye] Mehmet Akif Inan Educ & Res Hosp, Dept Child & Adolescent Psychiat, Sanliurfa, Turkey. [Karadag, Mehmet] Mardin State Hosp, Dept Child & Adolescent, Mardin, Turkey. [Mutluer, Tuba] Koc Univ, Dept Child & Adolescent Psychiat, Istanbul, Turkey. [Yektas, Cigdem] Duzce Univ, Dept Child & Adolescent Psychiat, Duzce, Turkey. [Coban, Nurdan] Sanliurfa Educ & Res Hosp, Dept Child & Adolescent Psychiat, Sanliurfa, Turkey. [Kandemir, Hasan] Celal Bayar Univ, Dept Child & Adolescent Psychiat, Manisa, Turkey. [Buber, Ahmet] Pamukkale Univ, Dept Child & Adolescent Psychiat, Denizli, Turkey. [Coskun, Seyma] Mersin State Hosp, Dept Child & Adolescent Psychiat, Mersin, Turkey. [Acikbas, Ufuk] Oxford Brookes Univ, Dept Hlth & Life Sci, Oxford, England. [Guler, Gulen] Mersin Univ, Dept Child & Adolescent Psychiat, Mersin, Turkey. [Celik, Fatma] Malatya State Hosp, Dept Psychol, Malatya, Turkey. [Altintas, Ebru] Baskent Univ, Dept Psychiat, Dr Turgut Noyan Med & Res Ctr, Adana, Turkey. [Giray, Asli] Alanya Alaaddin Keykubat Univ, Dept Genet & Bioengn, Alanya, Turkey. [Aka, Yeliz; Kutuk, Ozgur] Baskent Univ, Adana Dr Turgut Noyan Med & Res Ctr, Dept Immunol, Adana, Turkey.

Published
2020

20. with trichotillomania

Author

Kutuk, MO, Tufan, AE, Kilicaslan, F, Mutluer, T, Gokcen, C, Karadag, M, Yektas, C, Kandemir, H, Buber, A, Aksu, GG, Topal, Z, Giray, A, Celik, F, Acikbas, U, and Kutuk, O

Subjects
Obsessive-compulsive and related disorders, Trichotillomania, Cytokines, Immune system, Inflammation
Abstract

Immune dysregulation may be important in the etiology of obsessive-compulsive and related disordersandbody-focusedrepetitivebehaviors, such as Trichotillomania (TTM). The role of inflammation and inflammatory markers in TTM has received relatively little attention. This study was aimed to determine the expression levels of inflammatory markers (i.e. IL-1 beta, IL-1 alpha, IL-4, IL-6, IL-17, TNF-alpha and TGF-5) in peripheral blood mononuclear cells of children with TTM and healthy controls and to evaluate their association with clinical variables. Seventy-seven patients with TTM and 107 healthy controls were enrolled in the study. Peripheral blood was collected in standardized conditions. The mean age of patients and controls did not differ significantly (10.8 +/- 4.4 and 12.0 +/- 3.2 years; respectively). The majority of patients with TTM and controls were females (n = 55, 71.4 % and n = 55, 51.4 %; respectively); with a greater preponderance of females among TTM. Patients with TTM had significantly elevated expression levels of TNF-alpha, IL-6 and IL-17 compared to controls. However, the expression level of IL-4 was significantly reduced in TTM patients compared to controls. Accordingly, we found a proinflammatory state in TTM and those findings may suggest novel treatment options for TTM and further, crossdisciplinary studies focusing on neuro- inflammation in TTM conducted on larger samples are needed. C1 [Kutuk, Meryem Ozlem] Baskent Univ, Dept Child & Adolescent Psychiat, Dr Turgut Noyan Med & Res Ctr, Adana, Turkey. [Tufan, Ali Evren] Acibadem Mehmet Ali Aydinlar Univ, Dept Child & Adolescent Psychiat, Istanbul, Turkey. [Kilicaslan, Fethiye] Mehmet Akif Inan Educ & Res Hosp, Dept Child & Adolescent Psychiat, Sanliurfa, Turkey. [Mutluer, Tuba] Koc Univ, Dept Child & Adolescent Psychiat, Istanbul, Turkey. [Gokcen, Cem; Topal, Zehra] Gaziantep Univ, Dept Child & Adolescent Psychiat, Gaziantep, Turkey. [Karadag, Mehmet] Mardin State Hosp, Dept Child & Adolescent Psychiat, Mardin, Turkey. [Yektas, Cigdem] Duzce Univ, Dept Child & Adolescent Psychiat, Duzce, Turkey. [Kandemir, Hasan] Celal Bayar Univ, Dept Child & Adolescent Psychiat, Manisa, Turkey. [Buber, Ahmet] Pamukkale Univ, Dept Child & Adolescent Psychiat, Denizli, Turkey. [Aksu, Gulen Guler] Mersin Univ, Dept Child & Adolescent Psychiat, Mersin, Turkey. [Giray, Asli] Alanya Alaaddin Keykubat Univ, Dept Genet & Bioengn, Alanya, Turkey. [Celik, Fatma] Malatya Training & Res Hosp, Dept Child & Adolescent Psychiat, Malatya, Turkey. [Acikbas, Ufuk; Kutuk, Ozgur] Baskent Univ, Dept Med Genet, Adana Dr Turgut Noyan Med & Res Ctr, Adana, Turkey.

Published
2020

24. Lacunary d-Statistical Boundedness of Order α in Metric Spaces.

Author

Kandemir, H. Şengül, Et, M., and Çakallı, H.

Abstract

In this study, using a lacunary sequence we introduce the concepts of lacunary d-statistically convergent sequences of order α and lacunary d-statistically bounded sequences of order α in general metric spaces. [ABSTRACT FROM AUTHOR]

Published
2022

25. A recurrent case of adult favus successfully treated with terbinafine [Terbinafin ile Başarili Olarak Tedavi Edilen Bir Erişkin Nüks Favus Olgusu]

Author

Erkan D., Kolukirik I., Acar A., Kandemir H., Ilkit M., and Çukurova Üniversitesi

Subjects
Turkey, Favus, Terbinafine, Tinea capitis favosa, Trichophyton schöenleinii
Abstract

PubMedID: 26649420 Favus or tinea capitis favosa, is a chronic inflammatory dermatophytosis of the scalp. The disease is particularly common in children aged 6 to 10 years, more often in boys, and it also occurs in adults. Human-to-human transmission is therefore possible. Anthropophilic Trichophyton schöenleinii is responsible for over 95% of favus cases. In addition, there are rare cases of anthropophilic T.violaceum, zoophilic (T.verrucosum, T.quinckeanum, and Microsporum canis) and geophilic M.gypseum species recorded as agents of favus. It is also reported in mice (T.quinckeanum), poultry (M.gallinae), and cats (M.incurvatum). Favus is common in Iran, Nigeria, and China, however it has been reported rarely in the last two decades in Turkey. Although Turkish records are not sufficient to indicate an accurate incidence rate, favus is still present in Turkey. In this report, a 20-year-old female with favus was presented. She had squames and areas of alopecia on the right frontoparietal area of her scalp. Scalp biopsy and hair follicle samples were taken for histopathological examination and fungal culture. According to the conventional identification by mycological methods and internal transcribed spacer (ITS) sequencing analysis, the pathogen was identified as T.schöenleinii. The patient was treated with oral terbinafine (250 mg/day) for 4 weeks and topical isoconazole and ketoconazole for 6 weeks. Clinical recovery was observed after 6 weeks, however, fungal culture could not be repeated. Six months after the initial presentation, the patient's symptoms recurred due to the poor adherence and T.schöenleinii was repeatedly grown in culture. Antifungal treatment was administered with the same drugs for the same period. There was a clinical and mycological recovery 8 months after initial presentation. Favus, which is not frequently observed in adults, is an uncommon disease. Confusion arises in its diagnosis because other diseases have similar clinical appearances, and asymptomatic carriage have also been reported. For these reasons, and because of improvements in health conditions, treatment might be delayed. With accurate assessment of the patient's medical history, the clinical characteristics of the disease, and results of laboratory analyses, coupled with effective mycologist-clinician collaboration, it is possible for the patient to continue a healthy social life. Consequently, favus is still an important health problem encountered in Turkey.

Published
2015

26. Infrequent Production of Xanthomegnin by Fungal Strains Recovered from Patients with Ocular Mycoses

Author

Ozdemir, H.G., Kandemir, H., Curuk, A., Ilkit, M., Seyedmousavi, S., Ozdemir, H.G., Kandemir, H., Curuk, A., Ilkit, M., and Seyedmousavi, S.

Abstract

Contains fulltext : 172818.pdf (publisher's version ) (Closed access), Mycotoxins are putative virulence factors of fungi that play an important role in the pathogenesis of fungal infections. Mycotoxin production has been used as a diagnostic marker for the early diagnosis of fungal diseases. Using high-performance liquid chromatography, we investigated whether the fungal strains recovered from eye tissue samples obtained from patients with ocular mycoses produced the mycotoxin xanthomegnin. We tested 62 well-characterized strains of fungi, including Aspergillus spp. (n = 14), Exophiala spp. (n = 9), Fusarium spp. (n = 15), and several molds (n = 24). All isolates were identified to the species level using PCR and DNA sequencing of rRNA genes. We detected xanthomegnin activity (0.02 microg/ml) in one of the three Aspergillus flavus strains. However, we were unable to detect xanthomegnin in any of the other 61 fungal strains. Our result suggests that xanthomegnin production was infrequent in fungal strains recovered from patients with ocular mycoses.

Published
2016

27. Clinical and Laboratory Features of Six Cases of Candida and Dermatophyte Folliculitis and a Review of Published Studies

Author

Durdu, M., Guran, M., Kandemir, H., Ilkit, M., Seyedmousavi, S., Durdu, M., Guran, M., Kandemir, H., Ilkit, M., and Seyedmousavi, S.

Abstract

Contains fulltext : 172127.pdf (publisher's version ) (Closed access), Although some studies have investigated the epidemiological characteristics of Malassezia folliculitis (MF), little is known about the clinical features and laboratory characteristics of folliculitis caused by other fungi. In this prospective study, 158 patients with folliculitis were identified, and cytological and mycological examinations were performed. The positive fungal cultures were confirmed using conventional methods, ITS sequencing and HWP1 analysis. Additionally, an in vitro antifungal susceptibility test was performed. Of 158 patients with folliculitis, 65 (41.1 %) were found to have fungal folliculitis. The most common (90.8 %) fungal folliculitis was MF. Non-MF fungal folliculitis was detected in 6 (9.2 %) patients. Four patients were diagnosed with dermatophytic folliculitis (Trichophyton rubrum in three patients and Arthroderma vanbreuseghemii in one patient), and two patients were diagnosed with Candida albicans folliculitis. Although only 5 of the 6 samples were found to be positive via a potassium hydroxide test, all May-Grunwald-Giemsa-stained samples were positive. Both of the C. albicans isolates demonstrated a susceptibility profile to itraconazole, and all four dermatophytes were susceptible to terbinafine. All six patients completely recovered with systemic and topical treatment. This study revealed that dermatophytes and C. albicans are the primary causative agents of non-Malassezia fungal folliculitis. We compared our findings with published reports on fungal folliculitis.

Published
2016

28. Quality of Life and Psychopathology in Adolescence: Different or Similar Measuring Constructs?

Author

Stevanovic. D, Atilola, O, Singh Balhara, Y., P, Avicenna, M, Kandemir, H, Vostanis, P, Knez, R, Franic, T, and Petrov, P.

Subjects
humanities, quality of life, adolescence
Abstract

Background: It is widely held that with quality of life (QOL) questionnaires we could evaluate different aspects of well-being and functioning of people with mental health problems. However, research with adults indicates that there might be overlapping between questionnaires measuring aspects of mental health and QOL due to similarities in items representing factors underlying the two constructs. Data about how similar or different are factors underlying items of QOL measures and measures of general psychopathology among adolescents are lacking. Aims of the Study: To explore the underlying factorial structure of a QOL measure and a measure of general psychopathology considered together among adolescents. Methods: 2367 adolescents (1184 males, age mean 15.64 (1.28) years) from Serbia, India, Indonesia, Nigeria, Bulgaria, Croatia, and Turkey participated in an international project. They completed the Pediatric Quality of Life Inventory (PedsQL) as a QOL measure and the Strengths and Difficulties Questionnaire (SDQ) as a measure of general mental health problems. The PedsQL has 23 items in four scales: physical, emotional, social, and school functioning. The SDQ has 25 items in five scales: emotional, conduct, hyperactivity/inattention, and peer problems and prosocial behavior. An exploratory factor analytic approach was considered (principal axis factoring - PAF). Results: All PedsQL and SDQ items were subjected together to a PAF. Ten factors with a eugenvalue of ≥ 1 were extracted explaining 49.3% of the total variance. A majority of the items from both questionnaires loaded on one to three factors corresponding originally proposed scales of the questionnaires. Three PedsQL items (13% of all) and three SDQ items (12% of all) were cross-loading on factors containing items of the opposite questionnaire. Three PedsQL items from the emotional functioning scale (“afraid or scared”, “sad or blue” and “worrying about future”) cross-loaded on a factor containing SDQ items from the emotional problems scale, while three SDQ items (“obeys”, “afraid”, and “distracted”) cross-loaded on factors containing PedsQL items from the emotional or school functioning scale. Discussion: The results indicate that the factors underlying the PedsQL and SDQ measuring constructs are much more different than similar. There are about 13% of similar items in the questionnaires mostly representative of an underlying factor measuring emotional functioning. Implications for Further Research: Authors of any study with adolescents considering a QOL measure and a measure of psychopathology together have to correct the questionnaires’ scores for similar items to avoid treating study validity.

Published
2014

31. Relationships Between Psychopathology and Quality of Life Among Adolescents a Structural Equation Modeling Approach

Author

Stevanović, D, Atilola, O, Singh Balhara, YP, Avicenna, M, Kandemir, H, Vostanis, P, Knez, R, Franić, T, Petrov, P, and Vlaskalić, Z.

Subjects
quality of life, adolescents, psychopathology, humanities
Abstract

Purpose: One of the main characteristics of measuring quality of life (QOL) in psychopharmacology is in providing data about the impacts of specific treatments on different aspects of well-being and functioning [1]. Therefore, QOL and other similar patientreported outcome (PRO) measures are recognized by regulatory bodies as important outcome measures in clinical trials, drugs registration, and marketing processes as an important target for intervention. Nevertheless, the aspects of psychopathology and QOL are highly inter-correlated and no clear demarcations were made the concepts [2]. As a useful method for studying complex relationships between various constructs, structural equation modeling (SEM) has not received much attention to study psychopathology and QOL together. This study evaluated the relationships between aspects of QOL and mental health using a SEM approach among adolescents in an international sample. >Methods: In this study, adolescents from an international project participated [2]. Adolescents aged 14−18 years from Serbia, India, Indonesia, Nigeria, Bulgaria, Croatia, and Turkey completed the Pediatric Quality of Life Inventory (PedsQL) for QOL assessments and Strengths and Difficulties Questionnaire (SDQ) for mental health difficulties. Assuming that the aspects of psychopathology and QOL could be highly inter- correlated due to similarities in items, the PedsQL items with similar meaning to the SDQ items measuring psychopathology were omitted. A SEM model was tested for this purpose: one latent QOL variable represented by three indicators − scales derived from the PedsQL (Physical functioning, Social functioning, and School functioning) and two correlated predictors − mental difficulties (derived from the SDQ scores indicating significant psychopathology) and chronic condition/illness (the presence/absence of a chronic health problem). The following statistics was used to assess the adequacy of the model: Tucker Lewis Index − TLI (>0.95 excellent), the Comparative Fit Index − CFI (>0.95 excellent), and Root Mean Square Error of Approximation − RMSEA (

Published
2013

33. Elektif Sezaryan Ve Normal Vajınal Yolla Doğan Bebeklerde Acth, Kortizol, Büyüme Hormonu,Prolaktin Ve Kan Glukoz Düzeylerinin Karşılaştırılması

Author

KANDEMİR, H., BELET, N., AYDIN, M., and KÜÇÜKÖDÜK, Ş.

Abstract

Plasma ACTH, Cortisol, Growth Hormone, Prolactin, and Glucose Values in Neonates Delivered by Normal Vaginal Delivery and Cesarean SectionIn the early postnatal period, the differences in the plasma levels of stress hormones and glucose were investigated in healthy neonates born by normal vaginal delivery (VD) and elective cesarean section (C/S) whose mothers were healthy. Forty term neonates were included in the study (20 VD. 20 C/S). The plasma adrenoco'rticotrophic hormone (ACTH), growth hormone (GH), prolactin, and glucose levels of neonates were measured at 0., 4., and 24. hours. The plasma ACTH values were found higher in newborn born by VD. Serum Cortisol levels did not different at 0. and 4. hours in each group, but it was observed higher in neonates delivered by VD at 24. hours. Prolactin and GH levels were equal in neonates delivered by VD and C/S. The blood glucose levels were found lower in newborns delivered by C/S at 0. and 4. hours.The difference of blood glucose levels between the two groups disappeared at 24. hours.The higher plasma ACTH values in newborns delivered by VD man delivered by C/S lead us to think that the VD delivery caused more stress to the newborns. The plasma Cortisol. GH, and prolactin levels were not affected by delivery type. The blood glucose level was found lower in neonates delivered by C/S during early postnatal period, but these babies were able also to keep glucose homeostasis in the levels of VD babies. Normal spontan vajinal yolla (NSVY) ve elektif sezaryanıla (C/S) doğan bebeklerde doğum sonrası erken dönemlerde stresin vol açtığı hormon ve glukoz düzeylerindeki değişikliklerin araştırılması amacıyla, 20'si normal spontan vajinal yolla 20'si elektif se-zaryanla doğum yapan 40 sağlıklı annenin sağlıklı term bebekleri çalışmaya alındı. Bebeklerde adrenokortikotropik hormon (ACTH), kortizol, büyüme hormonu (BH). prolaktin ve kan şekeri düzeyleri 0., 4. ve 24. saatlerde periferik venöz kanda çalışıldı. ACTH düzeyleri her iki doğum şeklinde doğumda en yüksek düzeyde iken takip eden saatlerde azalma gösterdi. NSVY'la doğan bebeklerde ACTH düzeyleri elektif sezaryanla doğanlara göre daha yüksek saptandı (p0.05), 24. saat düzeyleri vajinal yolla doğanlarda sezaryanla doğanlardan daha yüksekti (p0.05). Vajinal yolla doğan bebeklerde 0. saat kan şeker düzeyleri daha yüksekti (p0.05).NSVY'la doğan bebeklerde plazma ACTH düzeyinin daha yüksek bulunması bu tip doğum şeklinin bebekler üzerinde daha fazla strese yol açtığını düşündürmektedir. Serum kortizol, BH ve prolaktin düzeylerinin doğum sekimden etkilenmediği görülmektedir. Glukoz homeostazı yönünden değerlendirildiğinde hayatın ilk saatlerinde sezaryanla doğan bebeklerin kan şeker düzeyleri normal yolla doğan bebeklerden düşük olmasına rağmen, hi-poglisemik değerlerinin gözlenmemesi, sezaryanla doğan bebeklerin de glukoz dengesini NSVY'la doğan bebekler kadar sağlayabildiğini göstermektedir.

Published
2009

35. Inhibitors of bacterial transcription initiation complex formation

Author

Ma, C, Yang, X, Kandemir, H, Mielczarek, M, Johnston, EB, Griffith, R, Kumar, N, Lewis, PJ, Ma, C, Yang, X, Kandemir, H, Mielczarek, M, Johnston, EB, Griffith, R, Kumar, N, and Lewis, PJ

Abstract

Antibiotic resistance is a growing global problem, with very few new compounds in development. Bacterial transcription is an underutilized target for antibiotics, which has been attributed to the similarity of the active site of RNA polymerases (RNAPs) across all domains of life and the ease with which resistance can arise through point mutation at multiple sites within this conserved region. In this study we have taken a rational approach to design a novel set of compounds that specifically target the formation of transcription initiation complexes by preventing the unique bacterial σ initiation factor from binding to RNAP. We have identified the region of RNAP to which these compounds bind and demonstrate that one compound, GKL003, has an inhibition constant in the low nanomolar range. This compound has activity against both Gram-positive and -negative organisms, including a community acquired methicillin-resistant strain of the major pathogen Staphylococcus aureus. © 2013 American Chemical Society.

Published
2013

36. Plasma ACTH, cortisol, growth hormone, prolactin, and glucose values in neonates delivered by normal vaginal delivery and cesarean section

Author

Kandemir H., Belet N., Aydin M., Küçüködük S., and Ondokuz Mayıs Üniversitesi

Subjects
Glucose, Neonate, Normal vaginal delivery, Cesarean section, Growth hormone, Cortisol, ACTH, Prolactin
Abstract

In the early postnatal period, the differences in the plasma levels of stress hormones and glucose were investigated in healthy neonates born by normal vaginal delivery (VD) and elective cesarean section (C/S) whose mothers were healthy. Forty term neonates were included in the study (20 VD, 20 C/S). The plasma adrenocorticotrophic hormone (ACTH), growth hormone (GH), prolactin, and glucose levels of neonates were measured at 0., 4., and 24. hours. The plasma ACTH values were found higher in newborn born by VD. Serum cortisol levels did not different at 0. and 4. hours in each group, but it was observed higher in neonates delivered by VD at 24. hours. Prolactin and GH levels were equal in neonates delivered by VD and C/S. The blood glucose levels were found lower in newborns delivered by C/S at 0. and 4. hours.The-difference of blood glucose levels between the two groups disappeared at 24. hours. The higher plasma ACTH values in newborns delivered by VD than delivered by C/S lead us to think that the VD delivery caused more stress to the newborns. The plasma cortisol. GH, and prolactin levels were not affected by delivery type. The blood glucose level was found lower in neonates delivered by C/S during early postnatal period, but these babies were able also to keep glucose homeostasis in the levels of VD babies.

Published
2001

41. Does the Strengths and Difficulties Questionnaire – self report yield invariant measurements across different nations? Data from the International Child Mental Health Study Group

Author

Stevanovic, D., Urbán, R., Atilola, O., Vostanis, P., Singh Balhara, Y. P., Avicenna, M., Kandemir, H., Knez, R., Franic, T., and Petrov, P.

Abstract

Aims.This study evaluated the measurement invariance of the strengths and difficulties questionnaire (SDQ) self-report among adolescents from seven different nations.Methods.Data for 2367 adolescents, aged 13–18 years, from India, Indonesia, Nigeria, Serbia, Turkey, Bulgaria and Croatia were available for a series of factor analyses.Results.The five-factor model including original SDQ scales emotional symptoms, conduct problems, hyperactivity–inattention problems, peer problems and prosocial behaviour generated inadequate fit degree in all countries. A bifactor model with three factors (i.e., externalising, internalising and prosocial) and one general problem factor yielded adequate degree of fit in India, Nigeria, Turkey and Croatia. The prosocial behaviour, emotional symptoms and conduct problems factor were found to be common for all nations. However, originally proposed items loaded saliently on other factors besides the proposed ones or only some of them corresponded to proposed factors in all seven countries.Conclusions.Due to the lack of a common acceptable model across all countries, namely the same numbers of factors (i.e., dimensional invariance), it was not possible to perform the metric and scalar invariance test, what indicates that the SDQ self-report models tested lack appropriate measurement invariance across adolescents from these seven nations and it needs to be revised for cross-country comparisons.

Published
2015
Full Text
View/download PDF

43. Role of personal and family factors in alcohol and substance use among adolescents: an international study with focus on developing countries.

Author

Atilola, O., Stevanovic, D., Balhara, Y. P. S, Avicenna, M., Kandemir, H., Knez, R., Petrov, P., Franic, T., and Vostanis, P.

Abstract

Accessible summary Study reveals that alcohol and substance use and abuse is common among adolescents sampled from developing countries, and that it may be as high as have been reported in the developed nations. The risk factors also appear similar., To this extent, current strategies to combat adolescent alcohol and substance abuse in developed countries can be adopted in developing countries as well. There is, however, a need to adapt some of these well-established intervention programmes into the reality of the developing countries. Peculiar challenge in these countries includes lack of human resource capacity in child and adolescent psychiatry. Therefore, such programmes will necessarily have to be simplified and implementable by allied professionals like teachers, social workers, school counsellors, nurses and spiritual advisers. Family cohesion - which is a potential strength of developing countries - also needs to be strengthened as a bulwark against adolescent involvement in social vices like alcohol and substance abuse., Abstract Most studies examining adolescent alcohol and substance use or abuse hardly include samples from developing countries. To bridge some gap, the prevalence and associated social correlates of alcohol and substance use and abuse was examined among a cohort of school-going adolescents sampled from seven developing countries. Alcohol and substance abuse was measured using the CRAFFT instrument, independent socio-demographic correlates were determined using regression models. A total of 2454 adolescents completed the study, among which 40.9% reported using either alcohol or at least one other substance during the previous 12 months. This was mostly alcohol (37.8%), followed by marijuana/hashish (8.6%) and other substances (8.1%). Among the adolescents who reported using at least one substance, 45% (18.3% of total sample) had CRAFFT scores indicative of problematic or hazardous substance use. Several personal and family factors were independently associated with use/abuse, and the modifiable nature of these factors calls for appropriate intervention strategies. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

44. Selective open pit mining and ore treatment at Croydon gold mine, North Queensland.

Author

Child R., North Queensland gold'89 conference Townsville, Queensland, Australia 18-Apr-8920-Apr-89, Kandemir H., Stafford G., Child R., North Queensland gold'89 conference Townsville, Queensland, Australia 18-Apr-8920-Apr-89, Kandemir H., and Stafford G.

Abstract

The deposits are all hard rock and mining is carried out by drill and blast technique. The drilling, blasting and extraction of the hanging wall waste are done prior to orebody extraction. Orebody definition and extraction are controlled by a Grade Control System. Ore is processed through the treatment plant which is designed to treat run of mine ore, mullock and tailings. Average recovery to date on run of mine ore is 90% gold and 45% silver., The deposits are all hard rock and mining is carried out by drill and blast technique. The drilling, blasting and extraction of the hanging wall waste are done prior to orebody extraction. Orebody definition and extraction are controlled by a Grade Control System. Ore is processed through the treatment plant which is designed to treat run of mine ore, mullock and tailings. Average recovery to date on run of mine ore is 90% gold and 45% silver.

Published
1989

45. A fundamental study on bacterial oxidation of sulphide minerals.

Author

Kandemir H., Extractive metallurgy symposium, Kandemir H., and Extractive metallurgy symposium

Abstract

A study of the bacterial oxidation of naturally occuring high-purity sulphide minerals (FeS2, Fe1-xS, CuFeS2, Cu2S) has been conducted using a mesophilic strain of T. ferroxidans. As well as metal analyses and solution pH, partitioning of sulphide sulphur into elemental sulphur and sulphate ion has been monitored. Partially oxidised sulphide substrates have been characterised at regular time intervals by x-ray diffraction methods and extra-cellular organic compounds reporting into leach solution have been identified by thin layer chromatography. The results indicate that the S0/SO42- partitioning of the sulphide substrates is independent of cell inoculum size and initial pulp density and varies with solution pH, Eh, leaching time and mineralogical properties of the individual sulphide minerals. The significance of results for applications in selective flotation, coal desulphurisation and agglomeration has been outlined., A study of the bacterial oxidation of naturally occuring high-purity sulphide minerals (FeS2, Fe1-xS, CuFeS2, Cu2S) has been conducted using a mesophilic strain of T. ferroxidans. As well as metal analyses and solution pH, partitioning of sulphide sulphur into elemental sulphur and sulphate ion has been monitored. Partially oxidised sulphide substrates have been characterised at regular time intervals by x-ray diffraction methods and extra-cellular organic compounds reporting into leach solution have been identified by thin layer chromatography. The results indicate that the S0/SO42- partitioning of the sulphide substrates is independent of cell inoculum size and initial pulp density and varies with solution pH, Eh, leaching time and mineralogical properties of the individual sulphide minerals. The significance of results for applications in selective flotation, coal desulphurisation and agglomeration has been outlined.

Published
1984

47. A Survey on Creative Cash-Flow Reporting in Croatia

Author

Aljinović Barać, Željana, Ovuka, Duška, Kandemir, H., Ozdasli, K., and Kala, E.

Subjects
Financial statements, creative accounting, cash flow statement, operating cash flow, Croatia
Abstract

Information about the cash flows reported in the Statement of Cash Flow (SCF) provides the data about the firm’s ability to generate cash and cash equivalents. Moreover, information about current cash flows, especially from operating activities, is a useful tool in the prediction of sustainable cash flow. In spite that International Financial Reporting Standards (IFRS) regulate the preparation and presentation of SCF in detail, there are still many shadow accounting items that enable creative accounting practices, because International Accounting Standard (IAS) 7 allows flexibility in the classification of loans, interests, dividends, etc (Mulford and Comiskey, 2005). Although creative accounting does not violate the law, it negatively affects the true and fair view of the firm’s financial statements. This paper provides insights into creative cash flow reporting practices in Croatia. The sample consists of 71 randomly selected accountants to whom questionnaires were electronically sent in the period from March until August 2020. Respondents' opinions on the importance of the data provided by SCF, as well as on the efficiency of existing accounting regulations in preventing creative accounting are researched. Also, the most common methods and objectives of cash flow manipulations are identified. Findings show that most respondents consider IAS 7 suitable for the application of creative accounting techniques, and identified the timing of revenues/expenses recognition over multiple financial reporting periods as the most often technique. Furthermore, manipulation of cash flows from operating activities is determined as a usual goal of creative accounting, and the stretching out payables, especially at the end of the reporting period, is identified as the most common way of boosting operating cash flow.

Published
2021

48. Elevated serum S-100B levels in children with temporal lobe epilepsy

Author

Abdurrahman Sönmezler, Akin Iscan, Sahabettin Selek, Hasan Kandemir, Mustafa Calik, Abdullah Taskin, Ibrahım Oz, Mahmut Abuhandan, 0-Belirlenecek, İŞCAN, AKIN, and Calik, M., Harran University School of Medicine, Department of Pediatric Neurology, Sanliurfa 63100, Turkey -- Abuhandan, M., Harran University School of Medicine, Department of Pediatrics, Sanliurfa, Turkey -- Sonmezler, A., Harran University School of Medicine, Department of Neurology, Sanliurfa, Turkey -- Kandemir, H., Harran University School of Medicine, Department of Child and Adolescent Psychiatry, Sanliurfa, Turkey -- Oz, I., Nigde Children's Hospital, Department of Biochemistry and Clinical Biochemistry, Nigde, Turkey -- Taskin, A., Harran University School of Medicine, Department of Biochemistry and Clinical Biochemistry, Sanliurfa, Turkey -- Selek, S., Harran University School of Medicine, Department of Biochemistry and Clinical Biochemistry, Sanliurfa, Turkey -- Iscan, A., BezmialemVakif University, Faculty of Medicine, Department of Pediatric Neurology, Istanbul, Turkey

Subjects
Male, Pathology, medicine.medical_specialty, Adolescent, Cross-sectional study, Clinical Neurology, Physiology, S-100B level, S100 Calcium Binding Protein beta Subunit, Temporal lobe, Elevated serum, Epilepsy, medicine, Humans, Nerve Growth Factors, Temporal lobe epilepsy, Child, Children, business.industry, Nervous tissue, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, S100 Proteins, Case-control study, Biochemical marker, General Medicine, medicine.disease, Serum samples, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, medicine.anatomical_structure, ComputingMethodologies_PATTERNRECOGNITION, Cross-Sectional Studies, Neurology, Epilepsy, Temporal Lobe, Case-Control Studies, Child, Preschool, Female, Neurology (clinical), InformationSystems_MISCELLANEOUS, business, Biomarkers
Abstract

PubMed ID: 23146618, Purpose: An elevated level of S-100B in serum is generally considered to be a biochemical marker of nervous tissue damage. According to our knowledge, no studies have evaluated the serum S-100B protein concentration in children with temporal lobe epilepsy. The objective of this study was to measure the serum levels of S-100B protein in pediatric cases with temporal epilepsy. Methods: This case-controlled cross-sectional study was performed at the Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, in Turkey. Serum S-100B protein levels were studied in 19 (12 females, 7 males) children with temporal lobe epilepsy and in 25 (15 females, 10 males) healthy control subjects. Serum samples were collected within 30 min after a complex partial seizure, and serum S-100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of protein (ECLIA kit, Roche® Diagnostics, Germany). Results: The mean serum concentration of S-100B protein was 0.12 ± 0.02 µg/L in the temporal lobe epilepsy group and 0.07 ± 0.01 µg/L in the control group. The patients showed significantly elevated S-100B protein levels compared with healthy controls (P < 0.001). Conclusion: Our data suggest that increased S-100B protein levels in the serum might reflect neuronal damage in the brains of children with temporal lobe epilepsy. These results do confirm the previous findings of elevated S-100B protein levels in adult patients with temporal lobe epilepsy. © 2012 British Epilepsy Association.

Published
2012

49. Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology.

Author

de Hoog S, Walsh TJ, Ahmed SA, Alastruey-Izquierdo A, Arendrup MC, Borman A, Chen S, Chowdhary A, Colgrove RC, Cornely OA, Denning DW, Dufresne PJ, Filkins L, Gangneux J-P, Gené J, Groll AH, Guillot J, Haase G, Halliday C, Hawksworth DL, Hay R, Hoenigl M, Hubka V, Jagielski T, Kandemir H, Kidd SE, Kus JV, Kwon-Chung J, Lockhart SR, Meis JF, Mendoza L, Meyer W, Nguyen MH, Song Y, Sorrell TC, Stielow JB, Vilela R, Vitale RG, Wengenack NL, White PL, Ostrosky-Zeichner L, and Zhang SX

Abstract

Medically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal pathogens complete their life cycle in environmental habitats or occur as commensals within or on the vertebrate body, but under certain conditions can thrive upon infecting humans. The extent of host damage in opportunistic infections largely depends on the portal and modality of entry as well as on the host's immune and metabolic status. Diseases caused by primary pathogens and common opportunists, causing the top approximately 80% of fungal diseases [D. W. Denning, Lancet Infect Dis, 24:e428-e438, 2024, https://doi.org/10.1016/S1473-3099(23)00692-8], tend to follow a predictive pattern, while those by occasional opportunists are more variable. For this reason, it is recommended that diseases caused by primary pathogens and the common opportunists are named after the etiologic agent, for example, histoplasmosis and aspergillosis, while this should not be done for occasional opportunists that should be named as [causative fungus] [clinical syndrome], for example, Alternaria alternata cutaneous infection. The addition of a descriptor that identifies the location or clinical type of infection is required, as the general name alone may cover widely different clinical syndromes, for example, "rhinocerebral mucormycosis." A list of major recommended human and animal disease entities (nomenclature) is provided in alignment with their causative agents. Fungal disease names may encompass several genera of etiologic agents, consequently being less susceptible to taxonomic changes of the causative species, for example, mucormycosis covers numerous mucormycetous molds.

Published
2024
Full Text
View/download PDF

50. Is intermediate risk really intermediate? Comparison of karyotype and non-invasive prenatal testing results of pregnancies at intermediate risk of trisomy 21 on maternal serum screening.

Author

Alkan Bulbul G, Kirtis E, Kandemir H, Sanhal CY, Yakut Uzuner S, Karauzum SB, and Mendilcioglu II

Abstract

The purpose of this study was to assess the additional contribution of karyotyping compared with genome-wide non-invasive prenatal testing (NIPT) for pregnancies at intermediate risk for trisomy 21 (T21), calculated using the maternal serum screening without major structural anomalies detected through sonography. Karyotype results of all pregnancies undergoing invasive prenatal diagnostic testing between January 2013 and March 2022 were obtained from a large hospital-based laboratory. Pregnancies with no major structural anomalies on ultrasound (including soft markers) and an intermediate risk for T21 on maternal serum screening were included in this study. The additional contribution of karyotyping for abnormal karyotype results was calculated after excluding results that could theoretically be identified with genome-wide NIPT. Among the 511 pregnancies analyzed, 13 (2.54%) were found to have abnormal karyotype results, 9 (1.76%) of which could theoretically have been detected with genome-wide NIPT. Within the cohort, 6/263 (2.28%) of women aged 35 years and older, and 3/248 (1.20%) of women younger than 35 years had results that could have been detected with genome-wide NIPT. After excluding results detectable using genome-wide NIPT, the additional contribution of karyotyping was found as 4/502 (0.79%) for the entire cohort, 2/257 (0.77%) for women aged 35 years and older, 2/245 (0.81%) for women younger than 35 years. Of the 511 examined pregnancies at intermediate risk for T21 by maternal serum screening, genome-wide NIPT would have failed to detect 4 of 13 abnormal karyotype results. The findings hold importance in guiding couples' informed decision-making processes regarding their choice of genetic screening and diagnostic testing in case of intermediate risk for T21., (© 2024 The Author(s). Journal of Genetic Counseling published by Wiley Periodicals LLC on behalf of National Society of Genetic Counselors.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results