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13 results on '"Kandeil, Manar A."'

5. Evaluation of antioxidant, antityrosinase, and anticancer activity of mucus extract from both Egyptian land snails, Eremina desertorum and Helix aspersa, with emphasis on their chemical profiles.

Author

Kandeil, Manar A. and Mona, Mahy M.

Subjects
*MUCUS, *ANTINEOPLASTIC agents, *SNAILS, *SUPEROXIDE dismutase, *HELA cells, *MARINE natural products
Abstract

The snail mucus provides several functions and is increasingly being exploited for medicinal and cosmetic purposes. This study aimed to determine the chemical profile of two snail mucus extracts: the garden snail (Helix aspersa) and the desert snail (Eremina desertorum). In addition, it elucidates the antityrosinase, antioxidant, and anticancer activities against the human cancer cell line epithelioid carcinoma (Hela). The mucus was extracted from the pedal glands of garden snails (H. aspersa) and desert snails (E. desertorum). 2,2‐Diphenyl‐1‐picrylhydrazyl assay and the content of catalase, glutathione‐S‐transferase, superoxide dismutase, and reduced glutathione were utilized to assess the antioxidative screening activity of the mucus extracts. Besides a tyrosinase inhibitor assay, anticancer activity on cervical cancer cells (Hela) was studied. Additionally, the two mucus samples' total protein, total lipid, fatty acid, and amino acid profiles were compared. The mucus from both snails exhibited antioxidant activity. E. desertorum is more effective in inhibiting tyrosinase activity and has better scavenging activity than H. aspersa mucus extract. Both extracts revealed inhibitory activity against Hela cells, with insignificant differences. Moreover, the results indicated higher protein, lipids, and fatty acids mucus content of E. desertorum extract than those of H. aspersa mucus extract. Both snail slimes' obtained different biological activities, and amino acid contents could be related to their specific functions and beneficial for medical applications, especially antihyperpigmentation. Research Highlights: Mucus from Egyptian land snails, Eremina desertorum, and Helix aspersa are a source for discovering novel drugsE. desertorum mucus has better scavenging activity than H. aspersa mucusMucus extracted from E. desertorum is more effective in inhibiting tyrosinase activity than H. aspersaE. desertorum mucus extract contains higher protein, lipids, and fatty acids content than H. aspersa [ABSTRACT FROM AUTHOR]

Published
2024
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12. Comparative Study of Antimicrobial Activity and Cytotoxicity of Saponin Extracted from Six Egyptian Sea-cucumber Species, Licorice, and Ginseng

Author

Eissa, Samia H., Salem, Hoda K., Omran, Nahla E., Kabbash, Amal M., Amer, Wesam H., and Kandeil, Manar A.

Abstract

Background: The study aimed to compare the antimicrobial activity and cytotoxicity of saponin extracted from six sea-cucumber species, licorice, and ginseng to determine the most potent one. Methods: Antimicrobial activity assessed by well diffusion and agar dilution methods. The inhibitory effects of the tested extracts on cell growth of Liver (HePG-2) and breast (MCF-7) cell lines assessed by MTT [3- (4, 5- dimethyl thiazol-2yl) - 2, 5- diphenyl tetrazolium bromide] assay. Results: The results revealed that licorice extract presented higher antibacterial activity against Gram-positive bacterial strains than sea-cucumber extracts; but has comparable results for Gramnegative (Salmonella tyhimurium, Klebsiella spp, and Acinetobacter baumanii). Holothuria atra body wall and Bohadschia tubules have the highest antifungal effect against Candida albicans, Candida krusei, Candida famata, Candida glabrata, and Candida tropicalis. Sea-cucumbers are more potent against fungal strains than licorice and ginseng extract. Licorice and ginseng presented higher cytotoxicity against HePG2 and MCF-7 cell lines than sea-cucumbers. Conclusion: This study promotes the use of licorice extract as a better antibacterial substance than sea-cucumber extracts; however, the use of sea-cucumber extracts as antifungal agents than herbal extracts. Also, we support the utilization of licorice and ginseng as a cytotoxic agent instead of seacucumbers to stop the fishing of animals and consequently save it from extinction.

Published
2021
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