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38 results on '"Kanazawa, Nobuhiko"'

1. Establishment of a New Hepatitis C Virus-1 b Replicon

Author

Enomoto, Nobuyuki, Sakamoto, Naoya, Kurosaki, Masayuki, Maekawa, Shinya, Tanabe, Yoko, Yamashiro, Tsuyoshi, Chen, Cheng-Hsin, Nakagawa, Mina, Kanazawa, Nobuhiko, Watanabe, Hideki, Sato, Chifumi, Watanabe, Mamoru, Omata, Masao, editor, and Okita, Kiwamu, editor

Published
2004
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7. Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-[alpha]

Author

Tanabe, Yoko, Sakamoto, Naoya, Enomoto, Nobuyuki, Kurosaki, Masayuki, Ueda, Eri, Maekawa, Shinya, Yamashiro, Tsuyoshi, Nakagawa, Mina, Chen, Cheng-Hsin, Kanazawa, Nobuhiko, Kakinuma, Sei, and Watanabe, Mamoru

Subjects
Ribavirin -- Health aspects, Ribavirin -- Research, Interferon -- Health aspects, Interferon -- Research, Hepatitis -- Care and treatment, Hepatitis -- Research, Hepatitis C virus -- Care and treatment, Hepatitis C virus -- Research, Health
Published
2004

8. Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-[alpha]-mediated apoptosis in Huh7 cells

Author

Miyasaka, Yuka, Enomoto, Nobuyuki, Kurosaki, Masayuki, Sakamoto, Naoya, Kanazawa, Nobuhiko, Kohashi, Takahiro, Ueda, Eri, Maekawa, Shinya, Watanabe, Hideki, Izumi, Namiki, Sato, Chifumi, and Watanabe, Mamoru

Subjects
Airborne infection -- Causes of, Airborne infection -- Research, Apoptosis -- Genetic aspects, Apoptosis -- Health aspects, Apoptosis -- Physiological aspects, Cells -- Genetic aspects, Cells -- Physiological aspects, Chemical inhibitors -- Physiological aspects, Gene expression -- Physiological aspects, Hepatitis C virus -- Health aspects, Hepatitis C virus -- Prevention, Patients -- Care and treatment, Patients -- Health aspects, Proteins -- Genetic aspects, Proteins -- Physiological aspects, Tumor necrosis factor -- Genetic aspects, Tumor necrosis factor -- Physiological aspects, Health
Published
2003

12. Exposure to 4‐nonylphenol induces a shift in the gene expression of gsdf and testis‐ova formation and sex reversal in Japanese medaka (Oryzias latipes).

Author

Horie, Yoshifumi, Kanazawa, Nobuhiko, Takahashi, Chiho, Tatarazako, Norihisa, and Iguchi, Taisen

Subjects
ORYZIAS latipes, GONADS, GENE expression, SEX differentiation (Embryology), BISPHENOL A, AQUATIC organisms
Abstract

The branched isomer mixture 4‐nonylphenol (4‐NP) has been used worldwide as a surfactant, and can have endocrine‐disrupting effects on aquatic organisms. For instance, 4‐NP induces the formation of testis‐ova (i.e., testicular and ovarian tissue in the same gonad) or male to female sex reversal of various teleost fishes. Recently, our group revealed that altered gsdf gene expression is associated with disruption of gonadal differentiation in Japanese medaka (Oryzias latipes) embryos exposed to methyltestosterone or bisphenol A, suggesting that gsdf might be useful as a biomarker for predicting the impact of endocrine‐disrupting chemicals (EDCs) on gonadal differentiation. Here, we used 4‐NP to examine further whether gsdf expression at the embryo stage is useful for predicting EDC impact on gonadal sex differentiation. When fertilized medaka eggs were exposed to 32 or 100 μg/L 4‐NP, testis‐ova in genetic males and sex reversal from genetic male to phenotypic female were observed. At stage 38 (just before hatching), 4‐NP exposure at 1‐100 μg/L did not affect gsdf expression in XX embryos compared with the nontreated control; however, in XY embryos, the gsdf expression in the 100 μg/L‐exposed group was significantly lower than that in the controls. The 4‐NP concentration at which gsdf expression was suppressed was equal to that at which testis‐ova and sex reversal were induced. These results indicate that expression of the gsdf gene at the embryonic stage in medaka is a useful biomarker for predicting the impact of EDCs on sexual differentiation. Recently, we revealed that the gsdf gene may be a useful biomarker for predicting endocrine‐disrupting chemicals (EDCs). We found that exposure to 4‐nonylphenol (4‐NP) induced testis‐ova or sex reversal and suppressed gsdf expression in Oryzias latipes. The concentration at which gsdf expression was suppressed by 4‐NP exposure was equal to that at which testis‐ova and sex reversal were induced, confirming that the gsdf gene in O. latipes embryos is a useful biomarker for predicting EDCs acting on gonadal sexual differentiation. [ABSTRACT FROM AUTHOR]

Published
2021
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13. Research Activities in the Department of Physical Therapy

Author

NISHIMURA, Atsushi, UEDA, Shouji, GOTO, Masahiro, SHINODA, Keiichi, NODA, Toru, KANAZAWA, Nobuhiko, KUMADA, Hitoshi, TAMACHI, Masahiro, HIRAYAMA, Tomoko, MAEDA, Chikako, AOYAMA, Hiroki, KAJIMOTO, Hiroyuki, SUGIMOTO, Akifumi, HORI, Hirofumi, MORITA, Emiko, YAMATO, Yousuke, YAMASHINA, Yoshihiro, MIZUTANI, Akira, SAKAGAMI, Nami, SHINBO, Kenji, NANIKAWA, Wataru, IWAMURA, Masaki, and YAMADA, Yoshihiro

Abstract

[Introduction] It is already fifty years since the Japanese law of physical therapists and occupational therapists has been effective. The physical therapist is referred by the law as "the professionals who implements the physical therapy to persons with disabilities under the prescription of medical doctors". In fifty years, however, the target of physical therapy has been significantly expanded. The subject for physical therapy now includes the patients in acute disease just after the surgical operation in addition to those in rehabilitation stage. In other words, the physical therapy is now recognized as the indispensable intervention to the subject with acute as well as chronic disorders. On the other hand, due to a rapid transition of the society into the aged society, prevention of diseases, and decline of activity capacity due to the aging have become major issues for the physical therapy., 5, KJ00010288999, P, Report

Published
2016

16. Regulation of Hepatitis C Virus Replication by Interferon Regulatory Factor 1

Author

Kanazawa, Nobuhiko, primary, Kurosaki, Masayuki, additional, Sakamoto, Naoya, additional, Enomoto, Nobuyuki, additional, Itsui, Yasuhiro, additional, Yamashiro, Tsuyoshi, additional, Tanabe, Yoko, additional, Maekawa, Shinya, additional, Nakagawa, Mina, additional, Chen, Cheng-Hsin, additional, Kakinuma, Sei, additional, Oshima, Shigeru, additional, Nakamura, Tetsuya, additional, Kato, Takanobu, additional, Wakita, Takaji, additional, and Watanabe, Mamoru, additional

Published
2004
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18. Hepatitis C viral dynamics in serum and the target cell during high-dose daily interferon-α with ribavirin combination therapy and twice-a-day interferon-β therapy

Author

Asahina, Yasuhiro, primary, Izumi, Namiki, additional, Uchihara, Masakatsu, additional, Noguchi, Osamu, additional, Tsuchiya, Kaoru, additional, Sakurai, Kaoru, additional, Kanazawa, Nobuhiko, additional, Itakura, Jun, additional, Miyake, Shozo, additional, and Sakai, Takahiro, additional

Published
2001
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21. Kanzo

Author

TSUCHIYA, Kaoru, primary, IZUMI, Namiki, additional, SAKURAI, Kaoru, additional, HAMANO, Hiroyasu, additional, KANAZAWA, Nobuhiko, additional, ITAKURA, Jun, additional, ASAHINA, Yasuhiro, additional, NOGUCHI, Osamu, additional, UCHIHARA, Masakatsu, additional, MIYAKE, Shouzou, additional, SAKAI, Takahiro, additional, HIMENO, Yoshirou, additional, and TAKI, Kazuhiro, additional

Published
2001
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22. Kanzo

Author

ITAKURA, Jun, primary, IZUMI, Namiki, additional, TSUCHIYA, Kaoru, additional, SAKURAI, Kaoru, additional, HAMANO, Kosei, additional, KANAZAWA, Nobuhiko, additional, ASAHINA, Yasuhiro, additional, NOGUCHI, Osamu, additional, UCHIHARA, Masakatsu, additional, HIMENO, Yoshiro, additional, MIYAKE, Shozo, additional, and SAKAI, Takahiro, additional

Published
2001
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23. Risk factors for developing new nodules of hepatocellular carcinoma (HCC) in the liver apart from the primary subsegment after complete ablation by microwave or radiofrequency

Author

Izumi, Namiki, primary, Noguchi, Osamu, additional, Asahina, Yasuhiro, additional, Uchihara, Masakatsu, additional, Hamano, Kousei, additional, Kanazawa, Nobuhiko, additional, Itakura, Jun, additional, Kawazoe, Seiji, additional, Miyake, Shozo, additional, and Sakai, Takahiro, additional

Published
2000
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24. Superparamagnetic iron oxide-enhanced magnetic resonance imaging is a beneficial modality for early diagnosis of hepatocellular carcinoma. A comparison with the vascular characterization by CT arteriography and CT arterioportography

Author

Asahina, Yasuhiro, primary, Izumi, Namiki, additional, Himeno, Yoshiro, additional, Hamano, Kosei, additional, Kanazawa, Nobuhiko, additional, Itakura, Jun, additional, Kawazoe, Seiji, additional, Noguchi, Osamu, additional, Uchihara, Masakatsu, additional, Miyake, Shozo, additional, and Sakai, Takahiro, additional

Published
2000
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30. A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression.

Author

Kanazawa, Nobuhiko, Izumi, Namiki, Tsuchiya, Kaoru, Sakurai, Kaoru, Hamano, Kosei, Itakura, Jun, Asahina, Yasuhiro, Noguchi, Osamu, Uchihara, Masakatsu, Miyake, Shozo, Miyakawa, Naoto, Kawachi, Yasuhiro, Shiotsu, Hidetoshi, Taki, Kazuhiro, Himeno, Yoshiro, Enomoto, Nobuyuki, Watanabe, Mamoru, and Sakai, Takahiro

Subjects
*NODULAR disease, *LIVER diseases, *ABDOMEN
Abstract

A 31-year-old Japanese male was admitted to our hospital for investigation of an asymptomatic nodular lesion of the liver detected by abdominal ultrasonography (US) during a routine medical examination. Computed tomography (CT) revealed a single, hypovascular mass 35 mm in diameter, within the left lobe of the liver. The tumor demonstrated hypointensity on T1-weighted, and hyperintensity on T2-weighted magnetic resonance (MR) imaging. Hematological and biochemical investigations were normal. There were no abnormalities of the gastrointestinal or urinary tracts. A left lateral segmentectomy of the liver was performed. Pathological examination of the nodule revealed a primary leiomyoma of the liver, with positive immunohistochemical staining for vimentin and desmin antigens. Primary leiomyoma of the liver is rare, with the majority of cases associated with immunodeficiency disorders. This patient had no evidence of any underlying disease. Primary leiomyoma of the liver should be considered when a nodular lesion is found in a patient without evidence of viral hepatitis. [Copyright &y& Elsevier]

Published
2002
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38. [Virus factors determining the outcome of IFN treatment for chronic hepatitis C].

Author

Kanazawa N, Nakagawa M, Watanabe H, Sakamoto N, and Enomoto N

Subjects
Drug Resistance, Viral genetics, Drug Therapy, Combination, Genotype, Humans, Mutation, Ribavirin therapeutic use, Treatment Outcome, Viral Envelope Proteins genetics, Viral Nonstructural Proteins genetics, Viral Proteins genetics, Antiviral Agents therapeutic use, Hepacivirus genetics, Hepatitis C drug therapy, Hepatitis C virology, Interferons therapeutic use
Published
2004

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