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156 results on '"Kanayama, Naoyuki"'

9. Multifraction stereotactic radiotherapy utilizing inhomogeneous dose distribution for brainstem metastases: a single-center retrospective analysis.

Author

Ikawa, Toshiki, Kanayama, Naoyuki, Arita, Hideyuki, Takano, Koji, Sakai, Mio, Morimoto, Masahiro, Tanaka, Kazunori, Yoshino, Yutaro, Tamenaga, Setsuo, and Konishi, Koji

Subjects
BRAIN tumors, DOSE fractionation, STEREOTACTIC radiotherapy, LINEAR accelerators, TUMOR treatment
Abstract

Brainstem metastases are challenging to manage owing to the critical neurological structures involved. Although stereotactic radiotherapy (SRT) offers targeted high doses while minimizing damage to adjacent normal tissues, the optimal dose fractionation remains undefined. This study evaluated the efficacy and safety of multifraction SRT with an inhomogeneous dose distribution. This retrospective study included 31 patients who underwent 33 treatments for 35 brainstem lesions using linear accelerator-based multifraction SRT (30 Gy in five fractions, 35 Gy in five fractions or 42 Gy in 10 fractions) with an inhomogeneous dose distribution (median isodose, 51.9%). The outcomes of interest were local failure, toxicity and symptomatic failure. The median follow-up time after brainstem SRT for a lesion was 18.6 months (interquartile range, 10.0–24.3 months; range, 1.8–39.0 months). Grade 2 toxicities were observed in two lesions, and local failure occurred in three lesions. No grade 3 or higher toxicities were observed. The 1-year local and symptomatic failure rates were 8.8 and 16.7%, respectively. Toxicity was observed in two of seven treatments with a gross tumor volume (GTV) greater than 1 cc, whereas no toxicity was observed in treatments with a GTV less than 1 cc. No clear association was observed between the biologically effective dose of the maximum brainstem dose and the occurrence of toxicity. Our findings indicate that multifraction SRT with an inhomogeneous dose distribution offers a favorable balance between local control and toxicity in brainstem metastases. Larger multicenter studies are needed to validate these results and determine the optimal dose fractionation. [ABSTRACT FROM AUTHOR]

Published
2024
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10. What is the optimal isodose line for stereotactic radiotherapy for single brain metastases using HyperArc?

Author

Sagawa, Tomohiro, Ikawa, Toshiki, Ohira, Shingo, Kanayama, Naoyuki, Ueda, Yoshihiro, Inui, Shoki, Miyazaki, Masayoshi, and Konishi, Koji

Subjects
RADIOTHERAPY treatment planning, STEREOTACTIC radiotherapy, BRAIN metastasis, GROSS margins, NECROSIS, LINEAR accelerators
Abstract

Purpose: The study aimed to investigate the optimal isodose line (IDL) in linear accelerator‐based stereotactic radiotherapy for single brain metastasis, using HyperArc. We compared the dosimetric parameters for target and normal brain tissue among six plans with different IDLs. Methods: This study included 30 patients with single brain metastasis. We retrospectively generated six plans for each tumor with different IDLs (80%, 70%, 60%, 50%, 40%, and 33%) using HyperArc. All treatment plans were normalized to the prescription dose of 35 Gy in five fractions which was covered by 95% of the planning target volume (PTV), defined by adding a 1.0 mm margin to the gross tumor volume (GTV). The dosimetric parameters were compared among the six plans. Results: For GTV > 0.1 cm3, the ratio of brain–GTV volumes receiving 25 Gy to PTV (V25Gy/PTV) was significantly lower at IDL 40%–70% than at IDL 80% and 33% (p < 0.01, retrospectively). For GTV < 0.1 cm3, V25Gy/PTV decreased continuously as IDL decreased. The values of D99% and D80% for GTV increased with decreasing IDL. An IDL of 50% or less was required to achieve D99% of greater than 43 Gy and D80% of greater than 50 Gy. The mean values of D99% and D80% for IDL 50% were 44.3 and 51.9 Gy. Conclusion: The optimal IDL is 40%–50% for GTV > 0.1 cm3. These lower IDLs could increase D99% and D80% of GTV while lowering V25Gy of normal brain tissue, which may help reduce the risk of radiation necrosis and improve local control. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Risk of thoracic soft tissue sarcoma after breast cancer radiotherapy: a population-based cohort study in Osaka, Japan.

Author

Ikawa, Toshiki, Kuwabara, Yoshihiro, Nakata, Kayo, Kanayama, Naoyuki, Morimoto, Masahiro, Miyashiro, Isao, and Konishi, Koji

Subjects
SARCOMA, BREAST, CANCER radiotherapy, BREAST cancer, CANCER diagnosis, JAPANESE people
Abstract

Postoperative radiotherapy for breast cancer reportedly increases the risk of thoracic soft tissue sarcomas, particularly angiosarcomas; however, the risk in the Japanese population remains unknown. Therefore, this study aimed to investigate the incidence of thoracic soft tissue sarcoma among patients with breast cancer in Japan and determine its association with radiotherapy. This retrospective cohort study used data from the population-based cancer registry of the Osaka Prefecture. The inclusion criteria were female sex, age 20–84 years, diagnosis of breast cancer between 1990 and 2010, no supraclavicular lymph node or distant metastasis, underwent surgery and survived for at least 1 year. The primary outcome was the occurrence of thoracic soft tissue sarcomas 1 year or later after breast cancer diagnosis. Among the 13 762 patients who received radiotherapy, 15 developed thoracic soft tissue sarcomas (nine angiosarcomas and six other sarcomas), with a median time of 7.7 years (interquartile range, 4.0–8.6 years) after breast cancer diagnosis. Among the 27 658 patients who did not receive radiotherapy, four developed thoracic soft tissue sarcomas (three angiosarcomas and one other sarcoma), with a median time of 11.6 years after diagnosis. The 10-year cumulative incidence was higher in the radiotherapy cohort than in the non-radiotherapy cohort (0.087 vs. 0.0036%, P  < 0.001). Poisson regression analysis revealed that radiotherapy increased the risk of thoracic soft tissue sarcoma (relative risk, 6.8; 95% confidence interval, 2.4–24.4). Thus, although rare, breast cancer radiotherapy is associated with an increased risk of thoracic soft tissue sarcoma in the Japanese population. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Dual-energy computed tomography-based iodine concentration as a predictor of histopathological response to preoperative chemoradiotherapy for pancreatic cancer

Author

Ohira, Shingo, primary, Ikawa, Toshiki, additional, Kanayama, Naoyuki, additional, Minamitani, Masanari, additional, Kihara, Sayaka, additional, Inui, Shoki, additional, Ueda, Yoshihiro, additional, Miyazaki, Masayoshi, additional, Yamashita, Hideomi, additional, Nishio, Teiji, additional, Koizumi, Masahiko, additional, Nakagawa, Keiichi, additional, and Konishi, Koji, additional

Published
2023
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21. Impact of magnetic resonance imaging-related geometric distortion of dose distribution in fractionated stereotactic radiotherapy in patients with brain metastases

Author

Ohira, Shingo, primary, Suzuki, Yuta, additional, Washio, Hayate, additional, Yamamoto, Yuki, additional, Tateishi, Soichiro, additional, Inui, Shoki, additional, Kanayama, Naoyuki, additional, Kawamata, Minoru, additional, Miyazaki, Masayoshi, additional, Nishio, Teiji, additional, Koizumi, Masahiko, additional, Nakanishi, Katsuyuki, additional, and Konishi, Koji, additional

Published
2023
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25. Additional file 1 of Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis

Author

Ikawa, Toshiki, Kanayama, Naoyuki, Arita, Hideyuki, Ohira, Shingo, Takano, Koji, Hirata, Takero, Morimoto, Masahiro, Teshima, Teruki, and Konishi, Koji

Abstract

Additional file 1: Figures S1–S6. Stacked histogram and bar chart of dose fractionation, isodose, number of metastases, maximum tumor volume, total tumor volume, and primary tumor, stratified by the occurrence of immediate side effects.

Published
2023
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26. Additional file 3 of Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis

Author

Ikawa, Toshiki, Kanayama, Naoyuki, Arita, Hideyuki, Ohira, Shingo, Takano, Koji, Hirata, Takero, Morimoto, Masahiro, Teshima, Teruki, and Konishi, Koji

Abstract

Additional file 3: Table S2. Pairwise comparisons of the incidence of immediate side effects, stratified by primary sites.

Published
2023
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27. Efficacy and Safety of Endoscopic Resection Followed by Chemoradiotherapy for Superficial Esophageal Squamous Cell Carcinoma: A Retrospective Study

Author

Hamada, Kenta, Ishihara, Ryu, Yamasaki, Yasushi, Hanaoka, Noboru, Yamamoto, Sachiko, Arao, Masamichi, Suzuki, Sho, Iwatsubo, Taro, Kato, Minoru, Tonai, Yusuke, Shichijo, Satoki, Matsuura, Noriko, Nakahira, Hiroko, Kanesaka, Takashi, Akasaka, Tomofumi, Takeuchi, Yoji, Higashino, Koji, Uedo, Noriya, Iishi, Hiroyasu, Kanayama, Naoyuki, Hirata, Takero, Kawaguchi, Yoshifumi, Konishi, Koji, and Teshima, Teruki

Published
2017
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29. Additional file 1 of Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0���I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study

Author

Ikawa, Toshiki, Ishihara, Ryu, Matsueda, Katsunori, Konishi, Koji, Yamamoto, Sachiko, Morimoto, Masahiro, Kanayama, Naoyuki, and Teshima, Teruki

Abstract

Additional file 1. Other chemotherapy regimens.

Published
2022
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30. Additional file 3 of Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0���I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study

Author

Ikawa, Toshiki, Ishihara, Ryu, Matsueda, Katsunori, Konishi, Koji, Yamamoto, Sachiko, Morimoto, Masahiro, Kanayama, Naoyuki, and Teshima, Teruki

Abstract

Additional file 3. Propensity scores of the standard-dose and high-dose groups and the receiver operating characteristic curve.

Published
2022
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31. Additional file 2 of Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0���I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study

Author

Ikawa, Toshiki, Ishihara, Ryu, Matsueda, Katsunori, Konishi, Koji, Yamamoto, Sachiko, Morimoto, Masahiro, Kanayama, Naoyuki, and Teshima, Teruki

Abstract

Additional file 2. Patient characteristics of the treatment groups with standardized mean differences before and after propensity score weighting.

Published
2022
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32. Improvement in bladder volume reproducibility using A‐mode portable ultrasound bladder scanner in moderate‐hypofractionated volumetric modulated arc therapy for prostate cancer patients

Author

Ohira, Shingo, primary, Komiyama, Riho, additional, Kanayama, Naoyuki, additional, Sakai, Kayo, additional, Hirata, Takero, additional, Yoshikata, Kento, additional, Ueda, Yoshihiro, additional, Miyazaki, Masayoshi, additional, Nakayama, Masashi, additional, Koizumi, Masahiko, additional, and Konishi, Koji, additional

Published
2022
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35. Prolonged overall treatment time negatively affects the outcomes of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: A propensity score-weighted, single-center analysis

Author

Ikawa, Toshiki, primary, Tabuchi, Takahiro, additional, Konishi, Koji, additional, Morimoto, Masahiro, additional, Hirata, Takero, additional, Kanayama, Naoyuki, additional, Wada, Kentaro, additional, Toratani, Masayasu, additional, Okawa, Sumiyo, additional, Ogawa, Kazuhiko, additional, and Teshima, Teruki, additional

Published
2021
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36. Impact of Multileaf Collimator Width on Dose Distribution in HyperArc Fractionated Stereotactic Irradiation for Multiple (-) Brain Metastases

Author

OHIRA, SHINGO, primary, UEDA, YOSHIHIRO, additional, KANAYAMA, NAOYUKI, additional, ISONO, MASARU, additional, INUI, SHOKI, additional, KOMIYAMA, RIHO, additional, WASHIO, HAYATE, additional, MIYAZAKI, MASAYOSHI, additional, KOIZUMI, MASAHIKO, additional, TESHIMA, TERUKI, additional, and KONISHI, KOJI, additional

Published
2021
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38. Improvement of image quality and assessment of respiratory motion for hepatocellular carcinoma with portal vein tumor thrombosis using contrast-enhanced four-dimensional dual-energy computed tomography

Author

Ohira, Shingo, primary, Kanayama, Naoyuki, additional, Wada, Kentaro, additional, Ikawa, Toshiki, additional, Hirata, Takero, additional, Kishi, Noriko, additional, Karino, Tsukasa, additional, Washio, Hayate, additional, Ueda, Yoshihiro, additional, Miyazaki, Masayoshi, additional, Koizumi, Masahiko, additional, and Teshima, Teruki, additional

Published
2021
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39. Elective Nodal Irradiation for Non-small Cell Lung Cancer Complicated With Chronic Obstructive Pulmonary Disease Affects Immunotherapy Αfter Definitive Chemoradiotherapy

Author

MORIMOTO, MASAHIRO, primary, NISHINO, KAZUMI, additional, WADA, KENTARO, additional, IMAMURA, FUMIO, additional, KONISHI, KOJI, additional, KUHARA, HANAKO, additional, TAMIYA, MOTOHIRO, additional, INOUE, TAKAKO, additional, KUNIMASA, KEI, additional, KIMURA, MADOKA, additional, HIRATA, TAKERO, additional, KANAYAMA, NAOYUKI, additional, TORATANI, MASAYASU, additional, KAWACHI, HAYATO, additional, OHIRA, KIKA, additional, NAKANISHI, ERINA, additional, OHIRA, SHINGO, additional, SAGAWA, TOMOHIRO, additional, MIYAZAKI, MASAYOSHI, additional, MATSUNAGA, TAKASHI, additional, KUMAGAI, TORU, additional, and TESHIMA, TERUKI, additional

Published
2020
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40. Intra-fractional patient setup error during fractionated intracranial stereotactic irradiation treatment of patients wearing medical masks: comparison with and without bite block during COVID-19 pandemic

Author

Ohira, Shingo, primary, Kanayama, Naoyuki, additional, Komiyama, Riho, additional, Ikawa, Toshiki, additional, Toratani, Masayasu, additional, Ueda, Yoshihiro, additional, Washio, Hayate, additional, Miyazaki, Masayoshi, additional, Koizumi, Masahiko, additional, and Teshima, Teruki, additional

Published
2020
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41. Prolonged Overall Treatment Time Negatively Affects the Outcomes of Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer: A Propensity Score-Weighted, Single-Center Analysis

Author

IKAWA, TOSHIKI, primary, Tabuchi, Takahiro, additional, Konishi, Koji, additional, Morimoto, Masahiro, additional, Hirata, Takero, additional, Kanayama, Naoyuki, additional, Wada, Kentaro, additional, Toratani, Masayasu, additional, Okawa, Sumiyo, additional, Ogawa, Kazuhiko, additional, and Teshima, Teruki, additional

Published
2020
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42. Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer

Author

Kanayama, Naoyuki, primary, Otozai, Shinji, additional, Yoshii, Tadashi, additional, Toratani, Masayasu, additional, Ikawa, Toshiki, additional, Wada, Kentaro, additional, Hirata, Takero, additional, Morimoto, Masahiro, additional, Konishi, Koji, additional, Ogawa, Kazuhiko, additional, Fujii, Takashi, additional, and Teshima, Teruki, additional

Published
2020
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46. Failure patterns after adjuvant chemoradiotherapy following endoscopic resection for superficial esophageal squamous cell carcinoma

Author

Ikawa, Toshiki, primary, Ishihara, Ryu, additional, Konishi, Koji, additional, Morimoto, Masahiro, additional, Hirata, Takero, additional, Kanayama, Naoyuki, additional, Yamamoto, Sachiko, additional, Matsuura, Noriko, additional, Wada, Kentaro, additional, Hayashi, Kenji, additional, Ogawa, Kazuhiko, additional, and Teshima, Teruki, additional

Published
2019
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47. Predictors of Acute Radiation Esophagitis in Non-small Cell Lung Cancer Patients Treated With Accelerated Hyperfractionated Chemoradiotherapy

Author

WADA, KENTARO, primary, KISHI, NORIKO, additional, KANAYAMA, NAOYUKI, additional, HIRATA, TAKERO, additional, UEDA, YOSHIHIRO, additional, KAWAGUCHI, YOSHIFUMI, additional, MORIMOTO, MASAHIRO, additional, KONISHI, KOJI, additional, IMAMURA, FUMIO, additional, OGAWA, KAZUHIKO, additional, and TESHIMA, TERUKI, additional

Published
2018
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48. Intra-fractional patient setup error during fractionated intracranial stereotactic irradiation treatment of patients wearing medical masks: comparison with and without bite block during COVID-19 pandemic.

Author

Ohira, Shingo, Kanayama, Naoyuki, Komiyama, Riho, Ikawa, Toshiki, Toratani, Masayasu, Ueda, Yoshihiro, Washio, Hayate, Miyazaki, Masayoshi, Koizumi, Masahiko, and Teshima, Teruki

Subjects
COVID-19 pandemic, MEDICAL masks
Abstract

The immobilization of patients with a bite block (BB) carries the risk of interpersonal infection, particularly in the context of pandemics such as COVID-19. Here, we compared the intra-fractional patient setup error (intra-SE) with and without a BB during fractionated intracranial stereotactic irradiation (STI). Fifteen patients with brain metastases were immobilized using a BB without a medical mask, while 15 patients were immobilized without using a BB and with a medical mask. The intra-SEs in six directions (anterior–posterior (AP), superior–inferior (SI), left–right (LR), pitch, roll, and yaw) were calculated by using cone-beam computed tomography images acquired before and after the treatments. We analyzed a total of 53 and 67 treatment sessions for the with- and without-BB groups, respectively. A comparable absolute mean translational and rotational intra-SE was observed (P  > 0.05) in the AP (0.19 vs 0.23 mm with- and without-BB, respectively), SI (0.30 vs 0.29 mm), LR (0.20 vs 0.29 mm), pitch (0.18 vs 0.27°), roll (0.23 vs 0.23°) and yaw (0.27 vs 22°) directions. The resultant planning target volume (PTV) margin to compensate for intra-SE was <1 mm. No statistically significant correlation was observed between the intra-SE and treatment times. A PTV margin of <1 mm was achieved even when patients were immobilized without a BB during STI dose delivery. [ABSTRACT FROM AUTHOR]

Published
2021
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