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260 results on '"Kanai, Osamu"'

3. Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study

Author

Nakatsuka, Yoshinari, Murase, Kimihiko, Sonomura, Kazuhiro, Tabara, Yasuharu, Nagasaki, Tadao, Hamada, Satoshi, Matsumoto, Takeshi, Minami, Takuma, Kanai, Osamu, Takeyama, Hirofumi, Sunadome, Hironobu, Takahashi, Naomi, Nakamoto, Isuzu, Tanizawa, Kiminobu, Handa, Tomohiro, Sato, Taka-Aki, Komenami, Naoko, Wakamura, Tomoko, Morita, Satoshi, Takeuchi, Osamu, Nakayama, Takeo, Hirai, Toyohiro, Kamatani, Yoichiro, Matsuda, Fumihiko, and Chin, Kazuo

Published
2023
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10. Comparison of the Efficacy and Safety of Thoracoscopy under Local Anesthesia in Patients Aged over and under 75 Years: A Single-center Experience

Author

Fujita, Kohei, primary, Saito, Zentaro, additional, Ito, Takanori, additional, Yoden, Makoto, additional, Imakita, Takuma, additional, Oi, Issei, additional, Kaku, Ryosuke, additional, Yamamoto, Yuki, additional, Kanai, Osamu, additional, Tachibana, Hiromasa, additional, Sawai, Satoru, additional, and Mio, Tadashi, additional

Published
2024
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13. Associations between Nocturnal Hypoxemia and Retinal Nerve Fiber Layer Thinning: The Nagahama Study.

Author

Nagasaki, Tadao, Miyake, Masahiro, Sato, Susumu, Murase, Kimihiko, Kawaguchi, Takahisa, Matsumoto, Takeshi, Nakatsuka, Yoshinari, Mori, Yuki, Ikeda, Hanako Ohashi, Sunadome, Hironobu, Hamada, Satoshi, Takahashi, Naomi, Togawa, Jumpei, Kanai, Osamu, Uiji, Sayaka, Wakamura, Tomoko, Tabara, Yasuharu, Tsujikawa, Akitaka, Matsuda, Fumihiko, and Hirai, Toyohiro

Subjects
NERVE fibers, HYPOXEMIA, SLEEP duration, OXYGEN saturation, OPTICAL coherence tomography, SLEEP apnea syndromes
Abstract

Rationale: There have been meta-analyses that showed reduced retinal nerve fiber layer (RNFL) thickness, which is a surrogate marker of glaucoma, in patients with obstructive sleep apnea (OSA). However, the sample sizes in these reports were small (<300), and the mechanism of RNFL thinning in patients with OSA was not revealed. Objectives: To investigate the relationship of RNFL thickness with nocturnal hypoxemia or hypoxemic burden in a large-scale study. Methods: In this epidemiological study, 8,309 community residents were enrolled. The actigraphy-modified 3% oxygen desaturation index (acti-ODI3%) and cumulative percentage of sleep time with oxygen saturation <90% (acti-CT90) modified by objective sleep duration using actigraphy were measured. The hypoxemic burden is shown as acti-CT90. Circumpapillary RNFL thickness was determined using optical coherence tomography. Results: Multivariable logistic analysis models revealed that an increase in acti-CT90 was significantly associated with mean RNFL thinning after adjusting for several factors in participants without glaucoma diagnosed or treated previously (β = −0.037; P = 0.009). There were significant differences in mean RNFL thickness among participants stratified according to acti-CT90 (>1.5 vs. ⩽1.5; P = 0.04). Although acti-ODI3% was significantly associated with acti-CT90 (β = 0.72; P < 0.0001), acti-ODI3% was not significantly associated with mean RNFL thickness in the multivariable logistic analysis (β = −0.011; P = 0.48). In addition, acti-CT90 was significantly associated with mean RNFL thickness both in the elderly (⩾60 yr; β = −0.058; P = 0.002) and nonelderly (<60 yr; β = −0.054; P = 0.007). Conclusions: Acti-CT90, but not acti-ODI3%, was associated with mean RNFL thinning in participants irrespective of age in the elderly or nonelderly. Further prospective studies are required to investigate whether the prevention of hypoxic burden, which was shown as acti-CT90 in this study, is favorable for RNFL thinning. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Nivolumab treatment of elderly Japanese patients with non-small cell lung cancer: subanalysis of a real-world retrospective observational study (CA209-9CR)

Author

Okishio, Kyoichi, Morita, Ryo, Shimizu, Junichi, Saito, Haruhiro, Sakai, Hiroshi, Kim, YoungHak, Hataji, Osamu, Yomota, Makiko, Nishio, Makoto, Aoe, Keisuke, Kanai, Osamu, Kumagai, Toru, Kibata, Kayoko, Tsukamoto, Hiroaki, Oizumi, Satoshi, Fujimoto, Daichi, Tanaka, Hiroshi, Mizuno, Keiko, Masuda, Takeshi, Kozuki, Toshiyuki, Haku, Takashi, Suzuki, Hiroyuki, Okamoto, Isamu, Hoshiyama, Hirotoshi, Yada, Nobumichi, and Ohe, Yuichiro

Published
2020
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21. Safety of flexible bronchoscopy and clinical course for elderly patients with suspected primary lung cancer.

Author

Saito, Zentaro, Oi, Issei, Ito, Takanori, Imakita, Takuma, Kanai, Osamu, Fujita, Kohei, and Mio, Tadashi

Subjects
TREATMENT of lung tumors, BIOPSY, PNEUMONIA, PATIENT safety, RETROSPECTIVE studies, DESCRIPTIVE statistics, PNEUMOTHORAX, FEVER, LUNG tumors, BRONCHOSCOPY, HEMORRHAGE, OLD age
Abstract

Background: There have been several reports demonstrating the safety of flexible bronchoscopy (FB) in the elderly, but none have focused specifically on lung cancer, which is a frequent biopsy procedure. Methods: In this study, we retrospectively evaluated the safety of FB and subsequent treatment in elderly patients with suspected primary lung cancer. Elderly patients were defined as 75 years of age or older. Results: A total of 141 patients, 77 in the elderly group and 64 in the nonelderly group, were reviewed. The median age of the elderly group was 80 years. Transbronchial lung biopsy was performed in more than 80% of all patients. Primary lung cancer was diagnosed in 42 (54.4%) of the elderly group and 35 (54.7%) of the nonelderly group (p = 0.38). Approximately 70% of the elderly patients with a confirmed diagnosis were treated, while more than half of the undiagnosed elderly patients had best supportive care. Complications such as bleeding, pneumothorax, fever, and pneumonia were similar in the elderly and nonelderly groups. Conclusions: This study suggests that flexible bronchoscopy can be performed as safely in the elderly as in the nonelderly. Furthermore, even elderly patients may have a greater chance of receiving treatment when a definitive diagnosis is achieved. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Associations between Sleep-Disordered Breathing and Serum Uric Acid and Their Sex Differences: The Nagahama Study

Author

Sunadome, Hironobu, primary, Murase, Kimihiko, additional, Tabara, Yasuharu, additional, Matsumoto, Takeshi, additional, Minami, Takuma, additional, Kanai, Osamu, additional, Nagasaki, Tadao, additional, Takahashi, Naomi, additional, Hamada, Satoshi, additional, Tanizawa, Kiminobu, additional, Togawa, Jumpei, additional, Uiji, Sayaka, additional, Wakamura, Tomoko, additional, Komenami, Naoko, additional, Setoh, Kazuya, additional, Kawaguchi, Takahisa, additional, Morita, Satoshi, additional, Takahashi, Yoshimitsu, additional, Nakayama, Takeo, additional, Hirai, Toyohiro, additional, Sato, Susumu, additional, Matsuda, Fumihiko, additional, and Chin, Kazuo, additional

Published
2023
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32. Kristen rat sarcoma virus (KRAS) G12F‐positive non‐small cell lung cancer mimicking KRAS G12C positivity: A case report.

Author

Oi, Issei, Ito, Takanori, Saito, Zentaro, Imakita, Takuma, Kanai, Osamu, Fujita, Kohei, Tachibana, Hiromasa, and Mio, Tadashi

Subjects
LUNG cancer, PROTEINS, GENETIC mutation, ONCOGENES, CANCER chemotherapy, POLYMERASE chain reaction, TUMOR markers, RARE diseases
Abstract

Searching for driver gene alteration is a prerequisite for chemotherapy of non‐small cell lung cancer. Due to its high sensitivity and concordance rate, the Amoy Dx Pan Lung Cancer PCR panel has been approved and is widely used in Japan. In this report, we describe a case in which a positive result for Kristen rat sarcoma virus (KRAS) exon2 p.G12F, a rare KRAS mutation, may have led to a false‐positive result for KRAS exon2 p.G12C on AMOY. Genetic analysis in this case was performed by LC‐SCRUM‐Asia. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Sleep disordered breathing and haemoglobin A1c levels within or over normal range and ageing or sex differences: the Nagahama study

Author

Matsumoto, Takeshi, primary, Murase, Kimihiko, additional, Tabara, Yasuharu, additional, Minami, Takuma, additional, Kanai, Osamu, additional, Takeyama, Hirofumi, additional, Sunadome, Hironobu, additional, Nagasaki, Tadao, additional, Takahashi, Naomi, additional, Nakatsuka, Yoshinari, additional, Hamada, Satoshi, additional, Handa, Tomohiro, additional, Tanizawa, Kiminobu, additional, Nakamoto, Isuzu, additional, Wakamura, Tomoko, additional, Komenami, Naoko, additional, Setoh, Kazuya, additional, Kawaguchi, Takahisa, additional, Tsutsumi, Takanobu, additional, Morita, Satoshi, additional, Takahashi, Yoshimitsu, additional, Nakayama, Takeo, additional, Sato, Susumu, additional, Hirai, Toyohiro, additional, Matsuda, Fumihiko, additional, and Chin, Kazuo, additional

Published
2022
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38. Sleep disordered breathing and haemoglobin A1c levels within or over normal range and ageing or sex differences: the Nagahama study.

Author

Matsumoto, Takeshi, Murase, Kimihiko, Tabara, Yasuharu, Minami, Takuma, Kanai, Osamu, Takeyama, Hirofumi, Sunadome, Hironobu, Nagasaki, Tadao, Takahashi, Naomi, Nakatsuka, Yoshinari, Hamada, Satoshi, Handa, Tomohiro, Tanizawa, Kiminobu, Nakamoto, Isuzu, Wakamura, Tomoko, Komenami, Naoko, Setoh, Kazuya, Kawaguchi, Takahisa, Tsutsumi, Takanobu, and Morita, Satoshi

Subjects
AGE differences, SLEEP disorders, SLEEP apnea syndromes, SLEEP duration, PULSE oximeters, SLEEP interruptions, AGE
Abstract

Summary: Recently an association between blood glucose dysregulation and sleep disruption was suggested. The association between sleep disordered breathing, most of which is due to obstructive sleep apnea (OSA) in the general population, and diabetic severity, as well as the impact of antidiabetic treatment, remains unclear. This study aimed to investigate these associations as well as age and sex differences. This cross‐sectional study evaluated 7,680 community participants as the main cohort (population‐based cohort). OSA was assessed by the 3% oxygen desaturation index from pulse oximetry, which was corrected for sleep duration obtained by wrist actigraphy. For arguing the limitations for using pulse oximetry, 597 hospitalised patients, who were assessed by the apnea–hypopnea index from attended polysomnography, were also evaluated as the validation cohort (hospital‐based cohort). Moderate‐to‐severe OSA was more prevalent as haemoglobin A1c (HbA1c) levels increased (<5.6%/5.6%–<6.5%/6.5%–<7.5%/≥7.5%, respectively) in both cohorts (p < 0.001), but only in those without antidiabetic treatment. The HbA1c level was an independent factor for moderate‐to‐severe OSA (population‐based cohort, odds ratio [OR] 1.26, 95% confidence interval [CI] 1.10–1.45; hospital‐based cohort, OR 1.69, 95% CI 1.22–2.33, per 1% increase). These associations were more prominent in the middle‐aged (aged <60 years) than in the elderly (aged ≥60 years) and in women than in men in both cohorts. The prevalence of moderate‐to‐severe OSA in patients with antidiabetic treatment in the hospital‐based cohort was ≥75% regardless of HbA1c levels. In conclusion, an association between the prevalence of OSA and HbA1c level even within or over the normal range was found only in patients without antidiabetic treatment and was more prominent in the middle‐aged and in women. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Association of Sleep-disordered Breathing and Blood Pressure with Albuminuria: The Nagahama Study

Author

Murase, Kimihiko, primary, Matsumoto, Takeshi, additional, Tabara, Yasuharu, additional, Ohler, Adrienne, additional, Gozal, David, additional, Minami, Takuma, additional, Kanai, Osamu, additional, Takeyama, Hirofumi, additional, Takahashi, Naomi, additional, Hamada, Satoshi, additional, Tanizawa, Kiminobu, additional, Wakamura, Tomoko, additional, Komenami, Naoko, additional, Setoh, Kazuya, additional, Kawaguchi, Takahisa, additional, Tsutsumi, Takanobu, additional, Morita, Satoshi, additional, Takahashi, Yoshimitsu, additional, Nakayama, Takeo, additional, Yanagita, Motoko, additional, Hirai, Toyohiro, additional, Matsuda, Fumihiko, additional, and Chin, Kazuo, additional

Published
2022
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47. Markers of cardiovascular disease risk in sleep-disordered breathing with or without comorbidities: the Nagahama Study

Author

Nakatsuka, Yoshinari, primary, Murase, Kimihiko, additional, Matsumoto, Takeshi, additional, Tabara, Yasuharu, additional, Nakamoto, Isuzu, additional, Minami, Takuma, additional, Takahashi, Naomi, additional, Takeyama, Hirofumi, additional, Kanai, Osamu, additional, Hamada, Satoshi, additional, Tanizawa, Kiminobu, additional, Handa, Tomohiro, additional, Wakamura, Tomoko, additional, Komenami, Naoko, additional, Morita, Satoshi, additional, Nakayama, Takeo, additional, Hirai, Toyohiro, additional, Matsuda, Fumihiko, additional, and Chin, Kazuo, additional

Published
2021
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