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Specific sequence features of the protospacer and protospacer-adjacent motif (PAM) are critical for efficient cleavage by CRISPR-Cas9, but current knowledge is largely derived from single-guide RNA (sgRNA) systems assessed in cultured cells. In this study, we sought to determine gRNA sequence features of a more native CRISPR-Cas9 ribonucleoprotein (RNP) complex with dual-guide RNAs (dgRNAs) composed of crRNA and tracrRNA, which has been used increasingly in recent CRISPR-Cas9 applications, particularly in zebrafish. Using both wild-type and HiFi SpCas9, we determined on-target cleavage efficiencies of 51 crRNAs in zebrafish embryos by assessing indel occurrence. Statistical analysis of these data identified novel position-specific mononucleotide features relevant to cleavage efficiencies throughout the protospacer sequence that may be unique to CRISPR-Cas9 RNPs pre-assembled with perfectly matched gRNAs. Overall features for wild-type Cas9 resembled those for HiFi Cas9, but specific differences were also observed. Mutational analysis of mononucleotide features confirmed their relevance to cleavage efficiencies. Moreover, the mononucleotide feature-based score, CRISPR-kp, correlated well with efficiencies of gRNAs reported in previous zebrafish RNP injection experiments, as well as independently tested crRNAs only in RNP format, but not with Cas9 mRNA co-injection. These findings will facilitate design of gRNA/crRNAs in genome editing applications, especially when using pre-assembled RNPs.

An experiment to measure an invariant mass of {\phi} mesons in nuclear medium is planned as the J-PARC E16 experiment. A trigger merging module (TRG-MRG) has been developed to detect leading-edges from 256 channels of discriminator-output signals and transmit those serialized hit data to trigger decision module with four optical links. The result of the test shows enough performance of the TRG-MRG as 1 ns TDC and data multiplexer with four 6.25 Gbps transceivers., Comment: 6 pages, 17 figures, conference record for the 21st IEEE Real Time Conference

We have measured, for the first time, the inclusive missing-mass spectrum of the $^{12}$C$(K^-, p)$ reaction at an incident kaon momentum of 1.8 GeV/$c$ at the J-PARC K1.8 beamline. We observed a prominent quasi-elastic peak ($K^-p \rightarrow K^-p$) in this spectrum. In the quasi-elastic peak region, the effect of secondary interaction is apparently observed as a peak shift, and the peak exhibits a tail in the bound region. We compared the spectrum with a theoretical calculation based on the Green’s function method by assuming different values of the parameters for the $\bar{K}$–nucleus optical potential. We found that the spectrum shape in the binding-energy region $-300 \, \text{MeV} < B_{K} < 40$ MeV is best reproduced with the potential depths $V_0 = -80$ MeV (real part) and $W_0 = -40$ MeV (imaginary part). On the other hand, we observed a significant event excess in the deeply bound region around $B_{K} \sim 100$ MeV, where the major decay channel of $K^- NN \to \pi\Sigma N$ is energetically closed, and the non-mesonic decay modes ($K^- NN \to \Lambda N$ and $\Sigma N$) should mainly contribute. The enhancement is fitted well by a Breit–Wigner function with a kaon-binding energy of 90 MeV and width 100 MeV. A possible interpretation is a deeply bound state of a $Y^{*}$-nucleus system.

In this paper, we present some of the most prominent realizations of the HBD concept in real experiments. We describe the first implementation of an HBD that was made in the CERES experiment at CERN using a spectrometer based on a doublet of hadron blind RICH detectors for the measurement of low-mass electron pairs in pA and AA collisions at the SPS. We next present a detailed account of a more extensive realization of the HBD that was made in the PHENIX experiment for the measurement of low-mass electron pairs in central heavy-ion collisions at RHIC, followed by a description of a very similar detector that is currently under construction at J-PARC for the measurement of vector mesons though their $e^+e^-$ decay in pA collisions. We conclude with a brief discussion of possible evolutions of the HBD concept as well as possible developments and uses of HBDs in experiments at the future Electron Ion Collider., Contribution to the Special Issue of Nuclear Instruments and Methods in Physics Research, "A RICH Legacy"

The current experimental information about interactions between the \(\eta \) meson and nucleon (N) is not enough to understand the nature of the \(\eta \) meson in a nucleus. We installed a new spectrometer and started an experiment to determine the \(\eta N\) scattering parameters at the Research Center for Electron Photon Science, Tohoku University. We present the current status of the experiment.

In the K1.8 beam-line at Hadron Experimental Facility of J-PARC, a new magnetic spectrometer S-2S is being installed. S-2S was designed to achieve a high momentum resolution of Δp/p = 6 × 10−4 in FWHM. Several strangeness-physics programs which require the high resolution will be realized by S-2S. The present article introduces J-PARC E70 (missing-mass spectroscopy of Ξ12Be) and E94 (missing-mass spectroscopy of Λ7Li, Λ10B, and Λ12C) experiments.

We measured the (K^−, π^+) reaction spectra at 1.8 GeV/c for the graphite and the polyethylene targets in the J-PARC E05 pilot experiment. By comparing the spectra for these two targets, it was found that Σ^*−(1385) in the ^11B nucleus is quite broadened. Furthermore, we also compared broadness of Σ^*−(1385) with K^*(892) obtained in the (K^−, p) spectrum. Σ^*−(1385) seems to be much more broadened in nuclei than K^*(892). We gave a possible interpretation, which is related to compositeness of decuplet baryons, for this situation.

We have measured an inclusive missing-mass spectrum of the 12 C(K−, p) reaction over wide energy region at the kaon incident momentum of 1.8 GeV/c at J-PARC K1.8 beam line. This measurement was carried out as a by-product of a pilot run of J-PARC E05 experiment, which searched for the Ξ-hypernuclei via 12C(K−, K+) reaction. We have compared the observed missing-mass spectrum with a DWIA calculation to study the K-nucleus interaction. In this comparison, we have changed the depth of both real and imaginary parts of the optical potential between the K and nucleus. It is found that the observed spectrum is best reproduced by the calculation of the potential depth of V0 ∼ −80 MeV (real part) and W0 ∼ −40 MeV (imaginary part). On the other hand, we have observed a definitive excess around the deeply bound region BK ≳ 100 MeV. The excess cannot be explained by the any optical potential and quasi-free background reaction. It is well fitted with a Breit-Wigner function with a binding energy of 90 MeV and a width of 100 MeV, which can be interpreted as a deeply bound Λ(1405) nucleus.

For the full understanding of baryon-baryon interactions in flavor SU(3), the ΞN interaction is the last missing piece of information. So far, we have revealed the ΛN interaction to be attractive (UΛ ≈ 30 MeV), and ΣN interaction to be repulsive in the medium to heavy mass-number region. The ΛΛ bonding energy is weakly attractive. While we have a few experimental observations suggesting the ΞN interaction would be attractive, there still exist large theoretical ambiguities weather it is attractive or not. Experimental determinations on the existence of bound states of Ξ hypernuclei by observing bound-state peaks are strongly awaited. In this report, a new preliminary result on the missing-mass spectrum of a 12C(K−, K+) reaction, which strongly suggests the existence of Ξ-hypernuclear bound states, is presented.For the full understanding of baryon-baryon interactions in flavor SU(3), the ΞN interaction is the last missing piece of information. So far, we have revealed the ΛN interaction to be attractive (UΛ ≈ 30 MeV), and ΣN interaction to be repulsive in the medium to heavy mass-number region. The ΛΛ bonding energy is weakly attractive. While we have a few experimental observations suggesting the ΞN interaction would be attractive, there still exist large theoretical ambiguities weather it is attractive or not. Experimental determinations on the existence of bound states of Ξ hypernuclei by observing bound-state peaks are strongly awaited. In this report, a new preliminary result on the missing-mass spectrum of a 12C(K−, K+) reaction, which strongly suggests the existence of Ξ-hypernuclear bound states, is presented.

Experimental results from the J-PARC E13 experiments are summarized. A new experimental set up of E13 has established a platform for the future γ-ray hypernuclear spectroscopy at J-PARC using kaon beams. New γ rays are identified in HeΛ4 and FΛ19. The energy of 1.406 MeV for the HeΛ4(1+→0+) transition confirmed a sizable effect of Charge Symmetry Breaking (CSB) in ΛN interaction in the A=4 hypernuclear system. The identification of four γ rays in FΛ19 is made for the first time in sd shell hypernuclei. Especially, energy spacing of the ground state doublet is found to be 315.5 keV. A good agreement with two theoretical calculations suggests that the theoretical formalism used in p shell hypernuclei is also applicable to heavier hypernuclei. Lastly, an overview of the future J-PARC E63 experiment is given.

We report on the first observation of γ rays emitted from an sd-shell hypernucleus, _{Λ}^{19}F. The energy spacing between the ground state doublet, 1/2^{+} and 3/2^{+} states, of _{Λ}^{19}F is determined to be 315.5±0.4(stat)_{-0.5}^{+0.6}(syst) keV by measuring the γ-ray energy of the M1(3/2^{+}→1/2^{+}) transition. In addition, three γ-ray peaks are observed and assigned as E2(5/2^{+}→1/2^{+}), E1(1/2^{-}→1/2^{+}), and E1(1/2^{-}→3/2^{+}) transitions. The excitation energies of the 5/2^{+} and 1/2^{-} states are determined to be 895.2±0.3(stat)±0.5(syst) and 1265.6±1.2(stat)_{-0.5}^{+0.7}(syst) keV, respectively. It is found that the ground state doublet spacing is well described by theoretical models based on existing s- and p-shell hypernuclear data.

We searched for the bound state of the neutron-rich Lambda-hypernucleus H-6(Lambda), using the Li-6(pi(-), K+)X double charge-exchange reaction at a pi-beam momentum of 1.2 GeV/c at J-PARC. A total of 1.4 x 10(12) pi(-) was driven onto a Li-6 target of 3.5-g/cm(2) thickness. No event was observed below the bound threshold, i.e., the mass of H-4(Lambda) + 2n, in the missing-mass spectrum of the Li-6(pi(-), K+) X reaction in the 2 degrees < theta(pi K) < 20 degrees angular range. Furthermore, no event was found up to 2.8 MeV/c(2) above the bound threshold. We obtained the double-differential cross section spectra of the Li-6(pi(-), K+)X reaction in the angular range of 2 degrees < theta(pi K) < 14 degrees. An upper limit of 0.56 nb/sr (90% C.L.) was obtained for the production cross section of the H-6(Lambda) hypernucleus bound state. In addition, not only the bound state region, but also the Lambda continuum region and part of the Sigma(-) quasifree production region of the Li-6(pi(-), K+) reaction were obtained with high statistics. The present missing-mass spectrum will facilitate the investigation of the Sigma(-) -nucleus optical potential for Sigma(-) -He-5 through spectrum shape analysis.

We have carried out a pilot data taking of the J-PARC E05 experiment to search for the bound state peaks of $^{12}_\Xi$Be in the $^{12}$C$(K^-, K^+)X$ reaction at 1.8 GeV/$c$. The measurement was performed at the K1.8 beam line of the J-PARC hadron experimental hall with a typical $K^-$ beam intensity of $6\times 10^{5}$ every six seconds. So far the best energy resolution of about 6 MeV$_{FWHM}$ was achieved with the existing SKS spectrometer. With a reasonable statistics, we have succeeded to observe peak structures in the bound region, which seems to suggest that the potential depth of $\Xi$ would be deeper than 14 MeV estimated in the previous measurements.

We have carried out an experiment to search for a neutron-rich hypernucleus, 6 H, by the 6 Li(π − , K + ) reaction at pπ− =1.2 GeV/c. The obtained missing-mass spectrum with an estimated energy resolution of 3.2 MeV (FWHM) showed no peak structure corresponding to the 6 H hypernucleus neither below nor above the 4 H+2n particle decay threshold. An upper limit of the production cross section for the bound 6 H hypernucleus was estimated to be 1.2 nb/sr at 90% confidence level.

A γ-ray spectroscopy experiment via the C 12 ( π + , K + ) reaction was carried out at KEK-PS in 2005. The K6 beam line and Superconducting Kaon Spectrometer (SKS) were employed to obtain a missing mass spectrum for 12ΛC. An upgraded germanium detector array, Hyperball2, was introduced to detect γ rays emitted from hypernuclei in coincidence with the ( π + , K + ) reaction. As a result of further analysis, a γ-ray peak at 6048 keV (preliminary) was newly observed and assigned as the M1 transition from the 6-MeV excited state to the ground state.

The fundamental motivation to study the non-mesonic weak decay (NMWD) of hypernuclei is that it provides the unique means for study of baryon–baryon weak interaction in SU3f symmetry group. The new channel of NMWD, namely the recently confirmed three-body channel, seems to have a surprisingly big branching ratio so that it makes its accurate measurement prerequisite of the baryon–baryon weak interaction study. We report a new result of \({\Gamma_{2N}(^{11}_{\Lambda} {\rm B})}\) from E508 experiment of KEK-PS, though preliminary yet, which agrees with the previous result of \({^{12}_{\Lambda}}\) C from the same experiment, those from FINUDA experiment and those of the recent theoretical predictions.

The first experiment at the J-PARC hadron facility, the J-PARC E19 experiment, aims at searching for the Θ + pentaquark in the hadronic reaction π − p → K − X using the missing-mass technique. Based on a superconducting magnet excited at 2.5 T, the spectrometer achieved the high mass resolution of 1.4 MeV/c2 for the Θ + production process. The first data taking was performed in the autumn of 2010. No significant structure was observed in the missing-mass spectrum. The upper limit obtained for the differential cross section is 0.26 μb/sr in the laboratory frame at a 90 % CL.

The fundamental motivation to study the non-mesonic weak decay (NMWD) of Λ hypernuclei is that it provides the unique channel for the information of the baryon–baryon weak interaction in SU3f group. The relative strength of the two main channels of NMWD whose decay processes are the Λp → np and Λn → nn has been the long standing puzzle during last several decades. The puzzling status has been settled down recently with the Γn / Γp value converging to \({\sim 0.5}\) . The large experimental values of Γn / Γp of the previous measurements turned out to be due to the surprisingly large contribution of the competing three-body NMWD, ΛNN → nNN process. This paper discusses about the first measurement of the branching ratio of the three-body NMWD process and the renormalized intra-nuclear cascade method adopted to disentangle the contribution of the three-body process out of those due to final state interaction. And the prospects of the more accurate measurement of the three-body process also are presented.

Recently we have reported the Γ n / Γ p value, ∼0.5, obtained in the exclusive coincidence measurement of the nucleon pairs in the back-to-back kinematics, which led to the resolution of the long standing Γ n / Γ p puzzle. We also have reported the branching ratio of the three-body process in the nonmesonic weak decay of 12ΛC to be 0.29 ± 0.13 by reproducing the quenching of the nucleon yields. At the same time we have finally obtained the absolute decay widths Γ n and Γ p taking account of the three-body processes. However, there still are serious inconsistencies not only between the experimental and theoretical values of important observables such as the decay asymmetry parameter α N M , but also between the basic formalisms of theoretical models. In order to provide more stringent guides for theoretical models, it is urgent to measure the fundamental observables, such as Γ n , Γ p , and Γ 2 N , with much improved accuracy. In this regards, the next extensive coincidence experiment is planned at the J-PARC 50GeV PS for the accurate determination of the decay widths to the level of ∼ 10 % statistical uncertainty and the measurement of Γ 2 N in the exclusive way.

The updated results from the hypernuclear γ -ray spectroscopy experiment, KEK-E566, are presented in this paper with emphasis on the γ -ray spin assignment. The KEK-E566 experiment was performed at the KEK-PS K6 beam line in 2005. In this experiment, C 12 ( π + , K + ) C Λ 12 reaction was used to produce C Λ 12 / B Λ 11 hypernuclei. A germanium detector array, Hyperball2, was constructed to detect γ rays emitted from the hypernuclei. Six hypernuclear γ -ray peaks were observed and assigned successfully.

A remote monitoring system was developed based on the software infrastructure of the Experimental Physics and Industrial Control System (EPICS) for the cryogenic system of superconducting magnets in the interaction region of the SuperKEKB accelerator. The SuperKEKB has been constructed to conduct high-energy physics experiments at KEK. These superconducting magnets consist of three apparatuses, the Belle II detector solenoid, and QCSL and QCSR accelerator magnets. They are each contained in three cryostats cooled by dedicated helium cryogenic systems. The monitoring system was developed to read data of the EX-8000, which is an integrated instrumentation system to control all cryogenic components. The monitoring system uses the I/O control tools of EPICS software for TCP/IP, archiving techniques using a relational database, and easy human-computer interface. Using this monitoring system, it is possible to remotely monitor all real-time data of the superconducting magnets and cryogenic systems. It is also convenient to share data among multiple groups.

The long standing Γn/Γp puzzle of NMWD has finally been solved recently. It appears that the reason behind the puzzle was the universal quenching of nucleon yields from the prediction of one-nucleon induced (1N-) NMWD. We have shown that the quenching of nucleon yields can be explained only when we include a fairly large contribution of the three-body process (Γ2N) in Γnm.

In this paper, a preliminary result from the latest hypernuclear γ -ray spectroscopy experiment (KEK-E566) is presented together with a short discussion. The experiment was performed at the KEK-PS K6 beam line in 2005. In this experiment, the 12C(π+, K +)12 ΛC reaction was employed to populate 12 ΛC/11 ΛB hypernuclei. A germanium detector array, Hyperball2, was constructed to detect γ -rays emitted from the hypernuclei produced. Three hypernuclear γ -ray peaks were observed and assigned.

The proton decay asymmetry, α p NM , of the polarized Λ-hypernuclei, Λ 5 He, Λ 12 C and Λ 11 B, has been investigated to understand the reaction mechanism of the non-mesonic weak-decay process. These Λ-hypernuclei were produced in the highest statistics ever via the (π +, K +) reaction at 1.05 GeV/c by using the SKS spectrometer at KEK 12 GeV PS. The results show that the α p NM are very small for these s-shell and p-shell hypernuclei.

Recent exclusive coincidence measurements of non-mesonic weak decays (NMWD) reported for the ratio of the partial decay width of neutron-induced-to-proton-induced NMWD, Γ n/Γ p , values of 0.45±0.11±0.03 and 0.51±0.13±0.04 for Λ 5 He and Λ 12 C, respectively. These observations agree well with the improved theoretical Γ n /Γ p ratios which are in the range of 0.3–0.7. It appears that the long-standing discrepancy between the experimental and theoretical values of Γ n /Γ p has finally been solved. However, when compared to the results of intra-nuclear cascade (INC) calculations, the observed numbers of both single nucleons and coincident nucleon pairs are strongly quenched. The quenching of the proton yield observed previously has been interpreted as an increase of the Γ n /Γ p ratio. On the other hand, significant contributions from the two-nucleon-induced three-body process ΛNN → nNN are predicted. Indeed, the angular correlation of the emitted nucleon pairs in the NMWD of Λ 12 C showed not only decay events in back-to-back kinematics, but also events with non-back-to-back kinematics. In this paper we show that the difficulties to extract the correct Γ n /Γ p ratio from the proton spectra is related to the three-body weak-interaction process which strongly quenches the nucleon yields.

The energy spacing between the spin-doublet bound state of _{Λ}^{4}He(1^{+},0^{+}) was determined to be 1406±2±2 keV, by measuring γ rays for the 1^{+}→0^{+} transition with a high efficiency germanium detector array in coincidence with the ^{4}He(K^{-},π^{-})_{Λ}^{4}He reaction at J-PARC. In comparison to the corresponding energy spacing in the mirror hypernucleus _{Λ}^{4}H, the present result clearly indicates the existence of charge symmetry breaking (CSB) in ΛN interaction. By combining the energy spacings with the known ground-state binding energies, it is also found that the CSB effect is large in the 0^{+} ground state but is vanishingly small in the 1^{+} excited state, demonstrating that the ΛN CSB interaction has spin dependence.

We have measured the angular correlation of the pair nucleons np and nn emitted from the nonmesonic weak decay (NMWD) of ^{12}_{Lambda}C produced via the (pi^+,K^+) reaction in coincidence measurement. The Lambda p -> np and Lambda n -> nn modes were clearly identified by measuring the back-to-back correlation of the emitted nucleon pairs which is the characteristic of two-body kinematics. From the measured nucleon pair numbers N_{nn} and N_{np}, the ratio Gamma_n/Gamma_p of the partial decay widths Gamma_n(Lambda n -> nn) and Gamma_p(Lambda p -> np) of ^{12}_{Lambda}C was extracted to be 0.51+-0.13(stat) +- 0.05(syst); this result is almost free from the ambiguity due to the nuclear final state interaction and 3-body decay process, which were inherent in the previous results. The obtained Gamma_n/Gamma_p ratio of ^{12}_{Lambda}C (p-shell) is close to that of ^5_{Lambda}He (s-shell). The results are consistent with those of recent theoretical calculations., 13 pages, 4figures, 1 table,re-submitted to Physics Letters B

We precisely measured π 0 branching ratios of 5 Λ He and 12 Λ C hypernuclei produced via the ( π + , K + ) reaction. Using these π 0 branching ratios with the π − branching ratios and lifetimes, we obtained the π 0 decay widths and the non-mesonic weak decay widths with an accuracy of ∼5% (stat) for both hypernuclei.

We performed a coincidence measurement of two nucleons emitted from the nonmesonic weak decay (NMWD) of 5ΛHe and 12ΛC formed via the ( π + , K + ) reaction. In both of n + p and n + n pair coincidence spectra, we observed a clean back-to-back correlation coming from the two-body decay of Λ p → n p and Λ n → n n , respectively. We obtained the ratio of the nucleon pair numbers, N n n / N n p (5ΛHe) = 0.45 ± 0.11 (stat) ± 0.03 (syst) in the kinematic region of cos θ N N − 0.8 . Since each decay mode was exclusively detected, the measured ratio should be close to the ratio of Γ ( Λ p → n n ) / Γ ( Λ n → n p ) . The Γ n / Γ p ratio was measured also for the NMWD of 12ΛC. It is also close to 0.5. Those ratios are consistent with recent theoretical calculations based on the heavy meson/direct quark exchange picture.

We have precisely measured the Λ → p π − decay width of He Λ 5 and demonstrated significantly larger α – Λ overlap than expected from an α – Λ potential with a central repulsion derived from YNG Λ –nucleon interaction.

We have measured both yields of neutron-proton and neutron-neutron pairs emitted from the non-mesonic weak decay process of He Λ 5 and C Λ 12 hypernuclei produced via the ( π + , K + ) reaction for the first time. We observed clean back-to-back correlation of the np - and nn -pairs in the coincidence spectra for both hypernucLei. The ratio of those back-to-back pair yields, N n n / N n p , must be close to the ratio of neutron- and proton-induced decay widths of the decay, Γ n ( Λ n → n n ) / Γ p ( Λ p → n p ) . The obtained ratios for each hypernuclei support recent calculations based on short-range interactions.

We have simultaneously measured the energy spectra of neutrons and protons emitted in the non-mesonic weak decays of He Λ 5 and C Λ 12 hypernuclei produced via the ( π + , K + ) reaction with much higher statistics than those of previous experiments. The neutron-to-proton yield ratios for both hypernuclei at a high energy threshold (60 MeV) were approximately equal to two, which suggests that the ratio of the neutron- and proton-induced decay channels, Γ n ( Λ n → n n ) / Γ p ( Λ p → n p ) , is about 0.5. In the neutron energy spectra, we found that the yield of the low-energy component is unexpectedly large, even for He Λ 5 .

The pentaquark $\Theta^+$ has been searched for via the $\pi^-p \to K^-X$ reaction with beam momenta of 1.92 and 2.01 GeV/$c$ at J-PARC. A missing mass resolution of 2 MeV (FWHM) was achieved but no sharp peak structure was observed. The upper limits on the production cross section averaged over the scattering angle from 2$^{\circ}$ to 15$^{\circ}$ in the laboratory frame were found to be less than 0.28 $\mu$b/sr at the 90\% confidence level for both the 1.92- and 2.01-GeV/$c$ data. The systematic uncertainty of the upper limits was controlled within 10\%. Constraints on the $\Theta^+$ decay width were also evaluated with a theoretical calculation using effective Lagrangian. The present result implies that the width should be less than 0.36 and 1.9 MeV for the spin-parity of $1/2^+$ and $1/2^-$, respectively., Comment: 12 pages, 9 figures; published version

We carried out an experiment to produce the neutron-rich hypernucleus H-6(Lambda) via the (pi(-), K+) reaction on Li-6 target at the pion beam momentum of 1.2 GeV/c (J-PARC E10). In order to calibrate the scale of the missing-mass or of the Lambda binding energy of the hypernucleus, we also measured the C-12(pi(+), K+)(12)(Lambda)12, p(pi(-), K+)Sigma(-) and p(pi(+), K+)Sigma(+) reactions. The experiment was performed at the J-PARC Hadron Hall K1.8 beam line in December 2012 and January 2013. The overall collected data sample corresponds to an integrated beam intensity of 1.65 x 10(12) pions