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12 results on '"Kamyar Jounaki"'

1. Laboratory evidence supports thrombolytic performance and blood compatibility of green-synthesized silver and gold nanomaterials

Author

Hamed Barabadi, Kamyar Jounaki, Kimiya Karami, Kiana Mobaraki, Hesam Noqani, Fatemeh Ashouri, Reza Jahani, and Chaudhery Mustansar Hussain

Subjects
Green synthesis, Silver and gold nanoparticles, Thrombolysis, Hemolysis, Industrial electrochemistry, TP250-261
Abstract

Thrombosis occurs through the accumulation of platelets and the formation of a blood clot in the blood vessels, which is a life-threatening condition. Thrombolytic therapy based on nanomaterials is a life-saving developing approach that lyses and dissolves thrombus by different mechanisms. Bioengineering of nanosized metallic particles is an innovative approach to preparing metallic nanoparticles (NPs) employing biological resources, such as plant extracts, bacteria, fungi, and algae, as reducing and capping agents. Biogenic synthesis of metallic NPs is an environmentally sound and safe route for engineering NPs. The biosynthesis of silver nanoparticles (SNPs) and gold nanoparticles (GNPs) is of great interest due to their unique physicochemical and biological performance. Further, among different applications of nanobiotechnology, the ability of biogenic metallic NPs, especially SNPs, and GNPs, to lyse blood clots has attracted enormous attention recently. However, the probable toxicity of NPs to red blood cells (RBCs) should be considered and addressed in medical usage. In this review, multiple studies are thoroughly discussed in which SNPs and/or GNPs were fabricated with various morphologies and sizes through green routes, and their thrombolytic and/or hemolytic activities were reviewed. Most of the studies indicated the significant thrombolytic performance of biosynthesized silver and gold particles. Furthermore, most of the studies reported dose-dependent hemolysis of these NPs. Further studies are required to validate the efficacy of SNPs and/or GNPs in clinics, and the other drawbacks of these NPs in the body should be addressed.

Published
2024
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2. Exploring the biological application of Penicillium fimorum-derived silver nanoparticles: In vitro physicochemical, antifungal, biofilm inhibitory, antioxidant, anticoagulant, and thrombolytic performance

Author

Hamed Barabadi, Kiana Mobaraki, Kamyar Jounaki, Salar Sadeghian-Abadi, Hossein Vahidi, Reza Jahani, Hesam Noqani, Omid Hosseini, Fatemeh Ashouri, and Salimeh Amidi

Subjects
Nano-biosynthesis, Mycosynthesis, Silver nanoparticles, Biological activity, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

This study showed the anti-candida, biofilm inhibitory, antioxidant, anticoagulant, and thrombolytic properties of biogenic silver nanoparticles (AgNPs) fabricated by using the supernatant of Penicillium fimorum (GenBank accession number OQ568180) isolated from soil. The biogenic AgNPs were characterized by using different analytical techniques. A sharp surface plasmon resonance (SPR) peak of the colloidal AgNPs at 429.5 nm in the UV–vis spectrum confirmed the fabrication of nanosized silver particles. The broth microdilution assay confirmed the anti-candida properties of AgNPs with a minimum inhibitory concentration (MIC) of 4 μg mL−1. In the next step, the protein and DNA leakage assays as well as reactive oxygen species (ROS) assay were performed to evaluate the possible anti-candida mechanisms of AgNPs representing an increase in the total protein and DNA of supernatant along with a climb-up in ROS levels in AgNPs-treated samples. Flow cytometry also confirmed a dose-dependent cell death in the AgNPs-treated samples. Further studies also confirmed the biofilm inhibitory performance of AgNPs against Candia albicans. The AgNPs at the concentrations of MIC and 4*MIC inhibited 79.68 ± 14.38% and 83.57 ± 3.41% of biofilm formation in C. albicans, respectively. Moreover, this study showed that the intrinsic pathway may play a significant role in the anticoagulant properties of AgNPs. In addition, the AgNPs at the concentration of 500 μg mL−1, represented 49.27%, and 73.96 ± 2.59% thrombolytic and DPPH radical scavenging potential, respectively. Promising biological performance of AgNPs suggests these nanomaterials as a good candidate for biomedical and pharmaceutical applications.

Published
2023
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5. Contributors

Author

Muhammad Aamir, K. Abhitha, Bilal Ahmad, Javeed Akhtar, Mehvish Ashiq, Sukesh Kumar Bajire, Kiran Bala, Hamed Barabadi, Ajit Behera, Madhulika Bhagat, Iman Khosravi Bigdeli, Negar Bozorgchami, Lorena Cornejo-Ponce, Vibha Devi, V. Devika, Abhishek S. Dhoble, A. Geetha, Abdul Ghaffar, Sougata Ghosh, Nellaiah Hariharan, Uzma Jabeen, Muhammad Jahangeer, Honey John, Renjith P. Johnson, Kuruvilla Joseph, Sherin Joseph, Kamyar Jounaki, Aditya Kumar, Preeti Kumari, Jeetesh Kushwaha, Meegle S. Mathew, Shalini Mohan, Hamed Morad, Ebrahim Mostafavi, Bushra Munir, Lakshmanan Muthulakshmi, Ehsan Nazarzadeh Zare, Rekha Pachaiappan, Kailash Pati Pandey, Mukesh Pasupuleti, Anmiya Peter, Elaheh Pishgahzadeh, Madhumita Priyadarsini, Sarmad Ahmad Qamar, Vincent Femilaa Rajan, Jyoti Rani, Sandhya Sadanandan, Hina Sahar, Prakash Kumar Sahoo, Fatemeh Salimi, Sandesh G. Sanjeeva, Appukuttan Saritha, Bishwarup Sarkar, M. Rehan H. Shah Gilani, Rajesh P. Shastry, Yashpal Singh, Apurba Sinhamahapatra, M.M. Sreejaya, P.J. Sreelekshmi, null Srishti, Sabu Thomas, Sirikanjana Thongmee, Hossein Vahidi, Kushal Yadav, and Mahdi Yeganeh

Published
2023

10. List of contributors

Author

Amitabha Acharya, Katya M. Aguilar-Pérez, Bhavna Alke, V. Ananthi, T. Angelin Swetha, A. Arun, Govindan Balasubramani, Monisha Banerjee, Hamed Barabadi, Maitree Bhattacharyya, Thulasinathan Boobalan, Abhispa Bora, Ariel P. Brown, Abdullah Çağlar, Zafer Ceylan, David Medina Cruz, G.H. Dinesh, Debjani Dutta, Ramakrishnan Geethalakshmi, Muthusamy Govarthanan, R. Guru Raj Rao, Habsah Hasan, Selcuk Hazir, Omid Hosseini, Chaudhery Mustansar Hussain, Hafiz M.N. Iqbal, J. Jeyakanthan, Kamyar Jounaki, Stefan Jurga, N.S. Kumar, P. Kumar, Nazan Kutlu, Ali Kılıçer, Lalita Ledwani, GS Lekshmi, Barbara M. Maciejewska, Mohammad Ali Mahjoub, Jennifer R. McCall, Samuel H. McCall, Dora I. Medina, Raciye Meral, Dasmawati Mohamad, K. Mohanrasu, Hamed Morad, Ebrahim Mostafavi, Sudip Nag, Anamika Nayak, J. Nirgund, SR Nivaz, Ebenezer Samuel James Obeth, Roberto Parra-Saldivar, Shama Parveen, Elahe Pishgahzadeh, Arnab Pramanik, Arivalagan Pugazhendhi, K.N. Purana, R Hari Krishna Raj, R. Karthik Raja, Shiwani Randhawa, Gustavo Ruiz-Pulido, Salar Sadeghian-Abadi, Himanshi Saini, Muthupandian Saravanan, Kathryn T. Sausman, D. Selvakumar, Chandni Sharma, S. Sil, N.B. Singh, Abdul Razack Sirajunnisa, G. Sivaprakash, Duraiarasan Surendhiran, Usman Taqui Syed, Syed Noeman Taqui, Oktay Tomar, Linh B. Truong, Shareefraza J. Ukkund, Hossein Vahidi, Mohini Verma, Karolina Wieszczycka, and Marta Woźniak-Budych

Published
2022

11. Bioengineering of green-synthesized silver nanoparticles: In vitro physicochemical, antibacterial, biofilm inhibitory, anticoagulant, and antioxidant performance

Author

Niloufar Talank, Hamed Morad, Hamed Barabadi, Faraz Mojab, Salimeh Amidi, Farzad Kobarfard, Mohammad Ali Mahjoub, Kamyar Jounaki, Neda Mohammadi, Ghazal Salehi, Milad Ashrafizadeh, and Ebrahim Mostafavi

Subjects
Staphylococcus aureus, Silver, Plant Extracts, Biofilms, Spectroscopy, Fourier Transform Infrared, Anticoagulants, Metal Nanoparticles, Bioengineering, Microbial Sensitivity Tests, Antioxidants, Anti-Bacterial Agents, Analytical Chemistry
Abstract

Green-synthesized nanobiomaterials can be engineered as smart nanomedicine platforms for diagnostic and therapeutic purposes in medicine. Herein, we investigated the bioengineering of silver nanoparticles (AgNPs) and evaluated their physicochemical, antibacterial, biofilm inhibitory, anticoagulant, and antioxidant performance. Characterization of the AgNPs was performed utilizing UV-visible, transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FT-IR). The spherical shaped AgNPs were proven by TEM and SEM techniques. Moreover, the XRD diffraction patterns demonstrated that the nanoparticles were in a crystalline state. The DLS represented the hydrodynamic particle size of the NPs at 49.62 nm at a pH of 9. The calculated minimum inhibitory concentration (MIC) of AgNPs toward Staphylococcus aureus (ATCC 25923) was 8 μg mL

Published
2022

12. Topical ocular delivery of vancomycin loaded cationic lipid nanocarriers as a promising and non-invasive alternative approach to intravitreal injection for enhanced bacterial endophthalmitis management

Author

Kamyar Jounaki, Mostafa Feghhi, Behzad Sharif Makhmalzadeh, and Asghar Heidarian

Subjects
Drug, Drug Carriers, Endophthalmitis, Chemistry, media_common.quotation_subject, Cationic polymerization, Pharmaceutical Science, Lipids, medicine.anatomical_structure, In vivo, Vancomycin, Cornea, Drug delivery, Intravitreal Injections, medicine, Distribution (pharmacology), Animals, Particle size, Rabbits, media_common, medicine.drug, Biomedical engineering
Abstract

Vancomycin (VCM) is a drug of choice for treating infections caused by Staphylococcus species, reported being the most causative agent of bacterial endophthalmitis. However, the ocular bioavailability of topically applied VCM is low due to its high molecular weight and hydrophilicity. The current study sought to explore whether the nanostructured lipid carriers (NLCs) fabricated via cold homogenization technique could improve ocular penetration and prolong the ophthalmic residence of VCM. A 23 full factorial design was adopted to evaluate the influence of different process and formulation variables on VCM-loaded NLC formulae. The optimized formula with the particle size of 96.4 ± 0.71 nm and narrow size distribution showed spherical morphology obtained by AFM and represented sustained drug release up to 67% in 48 h fitted to the Korsmeyer-Peppas model with probably non-Fickian diffusion kinetic. FTIR studies visualized the drug-carrier interactions in great detail. High encapsulation of VCM (74.8 ± 4.3% w/w) in NLC has been established in DSC and PXRD analysis. The optimal positively charged (+ 29.7 ± 0.47 mV) colloidal dispersion was also stable for 12 weeks at both 4 °C and 25 °C. According to in vivo studies, incorporation of VCM in NLC resulted in a nearly 3-fold increase in the intravitreal concentration of VCM after eye-drop instillation over control groups. Besides, microbiological evaluation admitted its therapeutic effect within five days is comparable to intravitreal injection of VCM. Further, the optimized formula was found to be nonirritant and safe for ophthalmic administration in RBC hemolytic assay. Also, fluorescent tracking of NLCs on rabbit's cornea showed an increase in corneal penetration of nanoparticles. Thus, it is possible to infer that the evolved NLCs are promising drug delivery systems with superior attainments for enhanced Vancomycin ophthalmic delivery to the eye's posterior segment and improved bacterial endophthalmitis management.

Published
2021

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