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1. Caractéristiques cliniques et génétiques du lepréchaunisme : à propos de 13 patients tunisiens

Author

Benkhalifa, S., primary, Guirat, M., additional, Affes, L., additional, Boujelbene, I., additional, Guidara, S., additional, Essaleh, W., additional, Ben Thabet, A., additional, Hmida, N., additional, Charfi, M., additional, Trabelsi, K., additional, Chelly, I., additional, Belguith, N., additional, Kammoun, H., additional, Fakhfekh, F., additional, and Benayed, I., additional

Published
2023
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8. The association between pain and sleep quality

Author

Aloulou, Y, primary, Rejeb, H, additional, Kammoun, H, additional, Greb, D, additional, Akrout, I, additional, Ben Abdelghaffar, H, additional, Hassen, H, additional, Fekih, L, additional, Smadhi, H, additional, and Megdich, M L, additional

Published
2022
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16. Des lipomes profonds multiples au cours d’une NEM1

Author

El Arbi, K., primary, Mnif, F., additional, Zargni, A., additional, Boujelben, K., additional, Lajmi, Y., additional, Abdelhedi, F., additional, Ben Salah, D., additional, Elleuch, M., additional, Charfi, N., additional, Rekik, N., additional, Mnif, M., additional, Hadj Kacem, F., additional, Kammoun, H., additional, and Abid, M., additional

Published
2021
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17. Occurrence of Hypopituitarism in Tunisian Turner Syndrome patients: familial versus sporadic cases

Author

Mnif-Feki, M., primary, Safi, W., additional, Bougacha-Elleuch, N., additional, Abid, G., additional, Moalla, M., additional, Elleuch, M., additional, Ben Salah, D. H., additional, Rekik, N., additional, Belguith, N., additional, Abdelhedi, F., additional, Kammoun, T., additional, Hachicha, M., additional, Charfi, N., additional, Mnif, F., additional, Kammoun, H., additional, Hadj Kacem, H., additional, Hadj-Kacem, F., additional, and Abid, M., additional

Published
2021
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18. Stable Isotopic Tracer Phospholipidomics Reveals Contributions of Key Phospholipid Biosynthetic Pathways to Low Hepatocyte Phosphatidylcholine to Phosphatidylethanolamine Ratio Induced by Free Fatty Acids

Author

Peng, K-Y, Barlow, CK, Kammoun, H, Mellett, NA, Weir, JM, Murphy, AJ, Febbraio, MA, Meikle, PJ, Peng, K-Y, Barlow, CK, Kammoun, H, Mellett, NA, Weir, JM, Murphy, AJ, Febbraio, MA, and Meikle, PJ

Abstract

There is a strong association between hepatocyte phospholipid homeostasis and non-alcoholic fatty liver disease (NAFLD). The phosphatidylcholine to phosphatidylethanolamine ratio (PC/PE) often draws special attention as genetic and dietary disruptions to this ratio can provoke steatohepatitis and other signs of NAFLD. Here we demonstrated that excessive free fatty acid (1:2 mixture of palmitic and oleic acid) alone was able to significantly lower the phosphatidylcholine to phosphatidylethanolamine ratio, along with substantial alterations to phospholipid composition in rat hepatocytes. This involved both a decrease in hepatocyte phosphatidylcholine (less prominent) and an increase in phosphatidylethanolamine, with the latter contributing more to the lowered ratio. Stable isotopic tracer phospholipidomic analysis revealed several previously unidentified changes that were triggered by excessive free fatty acid. Importantly, the enhanced cytidine diphosphate (CDP)-ethanolamine pathway activity appeared to be driven by the increased supply of preferred fatty acid substrates. By contrast, the phosphatidylethanolamine N-methyl transferase (PEMT) pathway was restricted by low endogenous methionine and consequently low S-adenosylmethionine, which resulted in a concomitant decrease in phosphatidylcholine and accumulation of phosphatidylethanolamine. Overall, our study identified several previously unreported links in the relationship between hepatocyte free fatty acid overload, phospholipid homeostasis, and the development of NAFLD.

Published
2021

19. Clinical utility of PROP1gene screening for patients with congenital hypopituitarism

Author

Moalla, M., Elleuch, M., Boujelbene, I., Frikha, H., Arous, M.K., Elloumi, Y., Kammoun, H., Feki-Mnif, M., Abid, M., Mejdoub-Rekik, N., and Hadj Kacem, H.

Abstract

The Prophet of Pit-1(PROP1) gene encodes a transcription factor restricted to anterior pituitary organogenesis, and is commonly implicated in non-syndromic combined pituitary hormone deficiency (CPHD). We aimed to evaluate the involvement of the PROP1gene mutations in a cohort of Tunisian patients with CPHD associated or not with Turner syndrome (TS).

Published
2024
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27. Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria

Author

Melo-Gonzalez, F, Kammoun, H, Evren, E, Dutton, EE, Papadopoulou, M, Bradford, BM, Tanes, C, Fardus-Reid, F, Swann, JR, Bittinger, K, Mabbott, NA, Vallance, BA, Willinger, T, Withers, DR, and Hepworth, MR

Subjects
commensal bacteria, mucosal tolerance, Immunology, Innate lymphoid cells, 11 Medical and Health Sciences, IgA
Abstract

Intestinal immune homeostasis is dependent upon tightly regulated and dynamic host interactions with the commensal microbiota. Immunoglobulin A (IgA) produced by mucosal B cells dictates the composition of commensal bacteria residing within the intestine. While emerging evidence suggests the majority of IgA is produced innately and may be polyreactive, mucosal-dwelling species can also elicit IgA via T cell-dependent mechanisms. However, the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses remain incompletely understood. Here we demonstrate that group 3 innate lymphoid cells (ILC3) regulate steady state interactions between T follicular helper cells (TfH) and B cells to limit mucosal IgA responses. ILC3 used conserved migratory cues to establish residence within the interfollicular regions of the intestinal draining lymph nodes, where they act to limit TfH responses and B cell class switching through antigen presentation. The absence of ILC3-intrinsic antigen presentation resulted in increased and selective IgA coating of bacteria residing within the colonic mucosa. Together these findings implicate lymph node resident, antigen-presenting ILC3 as a critical regulatory checkpoint in the generation of T cell-dependent colonic IgA and suggest ILC3 act to maintain tissue homeostasis and mutualism with the mucosal-dwelling commensal microbiota.

Published
2019

32. Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Author

Molloy, CP, Yao, Y, Kammoun, H, Bonnard, T, Hoefer, T, Alt, K, Tovar-Lopez, F, Rosengarten, G, Ramsland, PA, van der Meer, AD, van den Berg, A, Murphy, AJ, Hagemeyer, CE, Peter, K, Westein, E, Molloy, CP, Yao, Y, Kammoun, H, Bonnard, T, Hoefer, T, Alt, K, Tovar-Lopez, F, Rosengarten, G, Ramsland, PA, van der Meer, AD, van den Berg, A, Murphy, AJ, Hagemeyer, CE, Peter, K, and Westein, E

Abstract

UNLABELLED: Essentials Vessel stenosis due to large thrombus formation increases local shear 1-2 orders of magnitude. High shear at stenotic sites was exploited to trigger eptifibatide release from nanocapsules. Local delivery of eptifibatide prevented vessel occlusion without increased tail bleeding times. Local nanocapsule delivery of eptifibatide may be safer than systemic antiplatelet therapies. SUMMARY: Background Myocardial infarction and stroke remain the leading causes of mortality and morbidity. The major limitation of current antiplatelet therapy is that the effective concentrations are limited because of bleeding complications. Targeted delivery of antiplatelet drug to sites of thrombosis would overcome these limitations. Objectives Here, we have exploited a key biomechanical feature specific to thrombosis, i.e. significantly increased blood shear stress resulting from a reduction in the lumen of the vessel, to achieve site-directed delivery of the clinically used antiplatelet agent eptifibatide by using shear-sensitive phosphatidylcholine (PC)-based nanocapsules. Methods PC-based nanocapsules (2.8 × 1012 ) with high-dose encapsulated eptifibatide were introduced into microfluidic blood perfusion assays and into in vivo models of thrombosis and tail bleeding. Results Shear-triggered nanocapsule delivery of eptifibatide inhibited in vitro thrombus formation selectively under stenotic and high shear flow conditions above a shear rate of 1000 s-1 while leaving thrombus formation under physiologic shear rates unaffected. Thrombosis was effectively prevented in in vivo models of vessel wall damage. Importantly, mice infused with shear-sensitive antiplatelet nanocapsules did not show prolonged bleeding times. Conclusions Targeted delivery of eptifibatide by shear-sensitive nanocapsules offers site-specific antiplatelet potential, and may form a basis for developing more potent and safer antiplatelet drugs.

Published
2017

34. Profil fonctionnel respiratoire de la sarcoïdose

Author

Smadhi, H., primary, Khalfallah, I., additional, Kammoun, H., additional, Greb, D., additional, Benabdelghaffar, H., additional, Akrout, I., additional, Hassan, H., additional, Elfekih, L., additional, and Megdiche, M.L., additional

Published
2017
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35. L’hydatidose pulmonaire : encore fréquente

Author

Smadhi, H., primary, Louhaichi, S., additional, Khalfallah, I., additional, Kammoun, H., additional, Greb, D., additional, Benabdelghaffar, H., additional, Akrout, I., additional, Hassan, H., additional, Elfekih, L., additional, and Megdiche, M.-L., additional

Published
2017
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38. PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

Author

Lancaster, G. I., Kammoun, H. L., Kraakman, M. J., Kowalski, G. M., Bruce, C., Febbraio, M. A., Lancaster, G. I., Kammoun, H. L., Kraakman, M. J., Kowalski, G. M., Bruce, C., and Febbraio, M. A.

Abstract

Protein kinase R (PKR) has previously been suggested to mediate many of the deleterious consequences of a high-fat diet (HFD). However, previous studies have observed substantial phenotypic variability when examining the metabolic consequences of PKR deletion. Accordingly, herein, we have re-examined the role of PKR in the development of obesity and its associated metabolic complications in vivo as well as its putative lipid-sensing role in vitro. Here we show that the deletion of PKR does not affect HFD-induced obesity, hepatic steatosis or glucose metabolism, and only modestly affects adipose tissue inflammation. Treatment with the saturated fatty acid palmitate in vitro induced comparable levels of inflammation in WT and PKR KO macrophages, demonstrating that PKR is not necessary for the sensing of pro-inflammatory lipids. These results challenge the proposed role for PKR in obesity, its associated metabolic complications and its role in lipid-induced inflammation.

Published
2016

39. HDL modulates cardiac glucose metabolism and inflammation and improves cardiac function after myocardial ischemia-reperfusion injury

Author

Kingwell, B., primary, Heywood, S., additional, Richart, A., additional, Henstridge, D., additional, Alt, K., additional, Kiriazis, H., additional, Carey, A., additional, Kammoun, H., additional, Begum, H., additional, Delbridge, L., additional, Meikle, P., additional, Hagemeyer, C., additional, Febbraio, M., additional, Du, X.J., additional, and Siebel, A., additional

Published
2016
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43. Prognostic factors in non-small cell lung cancer

Author

Neffati, O., primary, Fekih, L., additional, Kammoun, H., additional, Ayari, A., additional, Mejri, I., additional, Smadhi, H., additional, Akrout, I., additional, Abdelghaffar, H., additional, Greb, D., additional, Hassene, H., additional, and Megdiche, M.L., additional

Published
2015
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45. Stratégies des exploitations agricoles familiales face aux nouveaux défis de l'irrigation. Quelques hypothèses

Author

Mahdi, M., Errahj, M., Elamrani, M., Kammoun, H., Kuper, Marcel, and Ali Hammani, Marcel Kuper, Abdelhafid Debbarh

Subjects
[SDV.SA] Life Sciences [q-bio]/Agricultural sciences
Abstract

Le programme d'ajustement structurel et le désengagement de l'Etat ont introduit un nouveau concept des rapports entre la puissance publique, représentée par les offices régionaux de mise en valeur agricole (ORMVA) et les usagers de l'eau d'irrigation. Ce concept est fondé sur le principe d'une gestion participative des ressources hydriques. Cette communication contribue à la réflexion sur “ les défis liés à l'accroissement des tensions sur des ressources en eau limitées et aux conséquences du désengagement de l'Etat et de la mondialisation. Elle porte sur l'analyse des stratégies adoptées par les producteurs, et notamment les exploitations agricoles de type familial, pour faire face aux contraintes provoquées par les nouvelles orientations en matière de politique agricole. Nous nous sommes intéressés tout particulièrement à l'expérience du périmètre irrigué du Gharb concernant la gestion sociale de l'eau. L'hypothèse sous-jacente à cette réflexion est que les modalités technico-économiques et financières mises en oeuvre pour la gestion de l'hydraulique dans le Gharb sont remises en cause par les évolutions en cours, notamment sous l'effet des facteurs politique, technico-économique, et même climatique.

Published
2005

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