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Autors determine the clinical effectiveness of including cytoflavin in intensive care of patients with severe combined traumatic brain injury. A prospective blind randomized controlled study was conducted on two groups involving 101 participants. In group I (58 patients), the intensive care was standard. In group II (43 patients), the intensive care included cytoflavin which was added beginning with the second day of the post-traumatic period. For this purpose, 10 ml of cytoflavin was dissolved in 200 ml of 10% aqueous solution of glucose and was administered intravenously at a speed of 140 drops (7 ml) per minute within 7 days. The use of cytoflavin in complex intensive care of severe combined traumatic brain injury within two days after injury (with the proper correction of blood circulation and respiration) reduced the number of multiple organ dysfunctions, the number is purulent-septic complications, the time of regress in multiple organ dysfunctions, and the reanimation period in intensive care department on the average by a factor of 1.4 - 1.6 (p < 0.005).

Research objective--determination of efficiency of intensive care with inclusion Cytoflavin in patients of old age in combined traumatic brain injury. A prospective controlled blind randomized study was conducted. In 1st group (21 people) the patients received a standard intensive care, in 2nd group (18 persons) Cytoflavin was included in complex intensive care. Using Cytoflavin starting from 2 days post-traumatic period (with the correction of blood circulation and respiration) had antioxidant and detoxification effects, contributed to the recovery rate of free radical and metabolic processes, reduced the degree of impairment in the structural-functional state of membranes and restored the conformational structure of membrane proteins in the earlier periods. Reduction in reactions of disadaptation led to regression of multiple organ dysfunctions, restoration the level of consciousness at an earlier date. The number of cases of severe respiratory distress syndrome decreased.

The structure and the circumstances of injury were studied in patients with severe TBI. 110 cases were studied retrospectively. More than 70% of the patients were from 20 to 60 years old, most of them men (80,91%). The main cause of injury was road accident (59,09%). 56,36% of patients were taken to hospital within the first hour after the accident. The average score by Glasgow scale was 8 (6;12). Lowest scores were registered in patients after railroad accidents [7,5(5;10)], in pedestrians [8(5;12)] and passengers [9 (6;12)] after road accidents and in criminal trauma cases [9,5(8;11)]. The most severe injuries by PTS scale were registered in patients after railroad accidents [50(44;56)], in criminal trauma cases [39(36;41)] and in pedestrians [31(22;42)]. The injuries were often accompanied by subarachnoid hemorrhage (46,36%). The most often outcome among patients with intracerebral hematoma, intraventricular hemorrhage, chest and pelvis injury was death. Thus we carried out retrospective analysis and studied the structure and the circumstances of TBI in Rostov on Don.

Immunity system changes and intoxication characteristics were studied in two groups of patients with pemphigus treated with traditional methods (group 1, 14 patients) and routine therapy combined with hemoperfusion, plasmapheresis, and enterosorption (group 2, 12 patients). During exacerbation pemphigus patients develop manifest changes in the immunity status in the presence of endotoxicosis. Introduction of hemoperfusion, plasmapheresis, and enterosorption in the complexes of treatment of pemphigus patients activates erosion epithelialization, helps sooner reduce the doses of corticosteroids whose total dose is reduced by 39 percent, improves cell-mediated and humoral immunity parameters, and is conducive to a more favorable time course of the body intoxication parameters.