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3 results on '"Kamila Cisak"'

1. An Unusual Case of Hemolytic Anemia Reversed with Liver Transplantation

Author

Vatsala Katiyar, Apaar Dadlani, Ishaan Vohra, Kamila Cisak, and Ashutosh Barve

Subjects
Spur cell anemia, Alcoholic cirrhosis, Liver transplant, Zieve's disease, Plasmapheresis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Spur cell anemia is acquired hemolytic anemia seen in patients with advanced liver disease, particularly in the setting of alcoholism, and warrants urgent liver transplant evaluation. We describe the case of a 58-year-old female with alcoholic cirrhosis who presented with worsening liver disease, profound anemia poorly responsive to blood transfusions, and multiple spur cells on the peripheral smear. She underwent a liver transplant, which led to the resolution of hematologic abnormalities and the need for transfusions. Our case highlights the significance of spur cell anemia as a harbinger of poor prognosis in patients with advanced liver disease and its reversibility with liver transplantation

Published
2022

2. Acute kidney injury after abdominal aortic aneurysm surgery: detailed assessment of early effects using novel markers

Author

Krzysztof Pawlicki, Katarzyna Antoniak, Tadeusz Fojt, Teresa Kowalewska-Twardela, Krzysztof Ziaja, Damian Ziaja, Jan Duława, Kokot M, Kamila Cisak, and Grzegorz Biolik

Subjects
Male, medicine.medical_specialty, Urinary system, Lipocalin, Fatty Acid-Binding Proteins, Sensitivity and Specificity, Severity of Illness Index, chemistry.chemical_compound, Lipocalin-2, Predictive Value of Tests, Proto-Oncogene Proteins, Internal Medicine, medicine, Humans, Cardiac Surgical Procedures, Vein, Aged, Creatinine, business.industry, Acute kidney injury, Interleukin-18, Acute Kidney Injury, Middle Aged, medicine.disease, Abdominal aortic aneurysm, Lipocalins, Surgery, Clamp, medicine.anatomical_structure, Early Diagnosis, chemistry, Interleukin 18, Female, Poland, business, Biomarkers, Acute-Phase Proteins, Aortic Aneurysm, Abdominal
Abstract

INTROduCTION One of the most severe complications of repair surgery for abdominal aortic aneurysms (AAA) is acute kidney injury (AKI). Even small rises in serum creatinine after surgery are associated with increased mortality. ObjECTIvEs The aim of the study was to assess the dynamics of AKI after elective AAA surgery using novel markers. PATIENTs ANd mEThOds The study group consisted of 14 patients with AAA. We measured serum neutrophil gelatinase‑associated lipocalin (NGAL) before, during (including intra‑abdominal vein levels before and after removal of aortic clamp), and within 2 days after surgery. Moreover, we assessed uri‑ nary NGAL, interleukin 18 (IL‑18), and liver‑type fatty acid‑binding protein (L‑FABP) before, during, and within 3 days after surgery. REsuLT s We observed a marked but nonsignificant increase in serum NGAL directly after clamp remo‑ val (75.21 ±55.83 vs. 46.37 ±21.60 ng/ml baseline value, P >0.05) and significantly elevated plasma NGAL at 2 hours (91.54 ±76.54 vs. baseline, P

Published
2012

3. Endothelium injury and inflammatory state during abdominal aortic aneurysm surgery: scrutinizing the very early and minute injurious effects using endothelial markers - a pilot study

Author

Kamila Cisak, Katarzyna Antoniak, Grzegorz Biolik, Krzysztof Ziaja, Kokot M, Tadeusz Fojt, Damian Ziaja, Krzysztof Pawlicki, and Jan Duława

Subjects
medicine.medical_specialty, intercellular adhesion molecule-1, Endothelium, P-selectin, macromolecular substances, von Willebrand factor, Pathogenesis, Von Willebrand factor, Clinical Research, E-selectin, medicine, cardiovascular diseases, ICAM-1, biology, urogenital system, business.industry, Acute kidney injury, General Medicine, medicine.disease, vascular cell adhesion molecule-1, Abdominal aortic aneurysm, Surgery, medicine.anatomical_structure, acute kidney injury, biology.protein, cardiovascular system, business
Abstract

Introduction One of the most severe complications of repair surgery for abdominal aortic aneurysms (AAA) is acute kidney injury (AKI). Acute kidney injury is an inflammatory process whose pathogenesis involves endothelial cells (EC). The aim of this study was to assess the dynamics of endothelium injury markers measured during elective AAA surgery which might confirm the inflammatory character of AKI. Material and methods The study group consisted of 14 patients with AAA. We measured plasma soluble forms of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, P-selectin as well as the levels of von Willebrand factor (vWF) before, during (including intra-abdominal vein levels before and after aortic clamp removal) and within 2 days after surgery. Results We have found a biphasic response of ICAM-1, VCAM-1 and P-selectin with an initial fall and subsequent rise. However, only VCAM-1 changes were significant compared to its baseline value. The maximum decrease of VCAM-1 was observed in the renal vein 5 min after aortic clamp removal (335.42 ±129.63 ng/ml vs. 488.90 ±169.80 ng/ml baseline value, p < 0.05), and the highest rise 48 h after aortic clamp removal (721.46 ±333.99 vs. baseline, p < 0.05). Conclusions Vascular cell adhesion molecule-1 turned out to be the most sensitive indicator of EC injury and inflammatory status after AAA surgery. During AAA surgery, soluble forms of P-selectin, ICAM-1 and VCAM-1 demonstrate a biphasic response with an initial fall and subsequent rise. These soluble forms could have a modulatory effect on the development of inflammation.

Published
2012

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