1. Host variations in SARS-CoV-2 infection
- Author
-
Zeynep Yağmur Karagülleoğlu, Vahdi Umut Bengi, Beyza Dönmüş, Hanife Ayşegül Mendi, Güldane Cengiz Seval, Sinan Ünal, Gizem Tunçer, Cansu Tekeli, Doruk Altiok, Devrim Demir-Dora, Güneysu Çetin, Buğrahan Regaip Kilinç, Büşra Özkara, Pelin Kiliç, Evren Suiçmez, Kamil Alkan, Dilara Sultan Namdar, Elif Zeynep Savci, Evrim Güneş Altuntaş, and Dilruba Beyza Uncuoğlu
- Subjects
Promoter Polymorphism ,Coronavirus disease 2019 (COVID-19) ,Physiology ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Prostate-Cancer ,Ace2 ,Disease ,Biology ,medicine.disease_cause ,Dna Methylation ,Microbiology ,Blood-Group ,Article ,Sars-Coronavirus Pathogenesis ,Pathogenesis ,Race (biology) ,Genetics ,medicine ,Molecular Biology ,Coronavirus ,Acute Respiratory Syndrome ,Epidemiological Factors ,Host (biology) ,SARS-CoV-2 ,Gene Polymorphisms ,Cell Biology ,Angiotensin-converting enzyme 2 (ACE2) ,transmembrane serine protease 2 (TMPRSS2) ,host genetics ,Susceptibility ,Immunology ,General Agricultural and Biological Sciences ,polymorphisms ,toll-like receptors (TLR) ,Receptor - Abstract
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.
- Published
- 2021