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The effectiveness of modified rock bolts reinforcement technology for floor heave control in gob-side entry retaining was studied in this paper. A finite-element numerical simulation was used to analyse stress-strain state of surrounding rocks before and after immediate floor reinforcement with six floor support schemes. It was found that after immediate floor reinforcement with rock bolts with diameter 32 mm and 96 mm, floor heave in retained gob-side gateroad reduces by 2.94 – 3.6 times respectively. The modification of rock bolt reinforcement scheme by the additional installation of piles in the entry corners was proposed. Piles installation significantly reduces the zone of horizontal and vertical post-peak strains in the gateroad floor. The best variant among compared ones is a floor support scheme with two corner piles, 1 m and 2 m long. With this scheme, floor heave decreases by 3.05 times. The comparison of the materials costs of the floor support schemes were performed. As a result, the most effective floor support scheme was proposed and prospects for the further progress of floor reinforcing technologies were outlined.

We present a major update of the HOCOMOCO collection that provides DNA binding specificity patterns of 949 human transcription factors and 720 mouse orthologs. To make this release, we performed motif discovery in peak sets that originated from 14 183 ChIP-Seq experiments and reads from 2554 HT-SELEX experiments yielding more than 400 thousand candidate motifs. The candidate motifs were annotated according to their similarity to known motifs and the hierarchy of DNA-binding domains of the respective transcription factors. Next, the motifs underwent human expert curation to stratify distinct motif subtypes and remove non-informative patterns and common artifacts. Finally, the curated subset of 100 thousand motifs was supplied to the automated benchmarking to select the best-performing motifs for each transcription factor. The resulting HOCOMOCO v12 core collection contains 1443 verified position weight matrices, including distinct subtypes of DNA binding motifs for particular transcription factors. In addition to the core collection, HOCOMOCO v12 provides motif sets optimized for the recognition of binding sites in vivo and in vitro, and for annotation of regulatory sequence variants. HOCOMOCO is available at https://hocomoco12.autosome.org and https://hocomoco.autosome.org., (© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)