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4. POS0191 A LUPUS FLARE RISK INDEX INFORMED BY SELECT ADAPTIVE AND TNF SUPERFAMILY IMMUNE MEDIATORS: VALIDATION IN A CONFIRMATORY COHORT

Author

Munroe, M. E., primary, Blankenship, D., additional, Defreese, D., additional, Holloway, A., additional, Purushothaman, M., additional, Dejager, W., additional, Macwana, S., additional, Guthridge, J. M., additional, Kamp, S., additional, Redinger, N., additional, Aberle, T., additional, Chakravary, E. F., additional, Arriens, C., additional, LI, Y., additional, Zeng, H., additional, Dezzutti, S., additional, Izmirly, P., additional, Thanarajasingam, U., additional, Kamen, D. L., additional, Buyon, J. P., additional, James, J. A., additional, and Jupe, E., additional

Published
2024
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5. OP0255 SELECT SOLUBLE MEDIATORS INFORM A REFINED LUPUS DISEASE ACTIVITY IMMUNE INDEX THAT CHARACTERIZES CLINICAL DISEASE ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOSUS

Author

Munroe, M. E., primary, Blankenship, D., additional, Defreese, D., additional, Holloway, A., additional, Purushothaman, M., additional, Dejager, W., additional, Macwana, S., additional, Guthridge, J. M., additional, Kamp, S., additional, Redinger, N., additional, Aberle, T., additional, Chakravary, E. F., additional, Arriens, C., additional, LI, Y., additional, Zeng, H., additional, Dezzutti, S., additional, Izmirly, P., additional, Thanarajasingam, U., additional, Kamen, D. L., additional, Buyon, J. P., additional, James, J. A., additional, and Jupe, E., additional

Published
2024
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10. OP0186 DISTINCT PERIPHERAL IMMUNOPHENOTYPING UNDERLINES HISTOPATHOLOGICAL FEATURES IN PATIENTS WITH LUPUS NEPHRITIS IN A LARGE MULTI-CENTER COHORT

Author

Horisberger, A., primary, Griffith, A., additional, Keegan, J., additional, Howard, K., additional, Pulford, J., additional, Murzin, E., additional, Hancock, B., additional, Ghosh, T., additional, Sasaki, T., additional, Fava, A., additional, Gutierrez Arcelus, M., additional, Eisenhaure, T., additional, Guthridge, J., additional, Arazi, A., additional, Hoover, P., additional, Dall’era, M., additional, Wofsy, D., additional, Kamen, D. L., additional, Kalunian, K., additional, Furie, R., additional, Belmont, H. M., additional, Izmirly, P., additional, Clancy, R., additional, Hildeman, D., additional, Woodle, E. S., additional, Apruzzese, W., additional, Mcmahon, M., additional, Grossman, J., additional, Barnas, J., additional, Payan-Schober, F., additional, Ishimori, M., additional, Weisman, M., additional, Kretzler, M., additional, Berthier, C., additional, Hodgin, J., additional, Putterman, C., additional, Hacohen, N., additional, Brenner, M., additional, Anolik, J. H., additional, Davidson, A., additional, James, J. A., additional, Raychaudhuri, S., additional, Petri, M. A., additional, Buyon, J., additional, Diamond, B., additional, (Amp), T. A. M. P. R. N., additional, Zhang, F., additional, Lederer, J., additional, and Rao, D., additional

Published
2023
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11. Mоdel for Analysis and Evaluation of Sustainable Cities in Bulgaria in the Context of Local Public Policy Appliance

Author

Nikolay Ivanov Tsonkov and Kamen Dimitrov Petrov

Subjects
smart development, territorial sustainability, sustainable development, sustainable and smart cities, bulgaria, Political science
Abstract

In recent years, the digitalization of the economy and the increasing demand for resources have created several challenges for developing countries, their regions, and urban agglomerations. Therefore, many governments have undertaken significant changes in the policies applied to developing regions and cities. These new concepts are aimed at gradually building sustainable and smart cities. This is the response of countries to new challenges such as the digital environment, combating climate change, and maintaining favorable living conditions due to the strong environmental and socio-economic degradation. In this regard, the authors set as their main research objective to analyze and assess the sustainability of cities and the surrounding territory by implementing sustainable development policies at all levels. A major task and difficulty for the authors is to build upon and refine a model that can be used to assess sustainable and smart cities. In this paper, the authors propose an approach to studying sustainable cities, thus evaluating the effects of policies implemented in this field. The model includes the main groups of indicators that are used to analyze the sustainable and smart development of municipalities in the Northeast region of Bulgaria. Based on these indicators, data is collected, and processed, and comparative and statistical analysis is carried out to assess their sustainability and intelligence. The authors reach important conclusions such as an unsatisfactory level of sustainable and intelligent development, although the environment and conditions at the national level are favorable. In fact, in Bulgaria, based on the assessment of the studied municipalities in the Northeast region, it is clear that we cannot talk about sustainable cities because Bulgarian municipalities are still at the beginning of this development path.

Published
2024

16. 1207 Update on Progress of the Mesenchymal Stromal Cell Trial in Refractory Lupus

Author

Kamen, D, primary, Lim, SS, additional, Ramsey-Goldman, R, additional, Kalunian, K, additional, Mackay, M, additional, Khosroshahi, A, additional, Sheikh, S, additional, Shah, U, additional, Goldmuntz, E, additional, Welch, B, additional, Ishimori, M, additional, Arriens, C, additional, Nietert, P, additional, Sirline, L, additional, Martin, R, additional, and Gilkeson, G, additional

Published
2022
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17. Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes.

Author

Choi, M. Y., Hanly, J., Bae, S.-C., Romero-Diaz, J., Sanchez-Guerrero, J., Bernatsky, S., Wallace, D. J., Isenberg, D. A., Rahman, A., Merrill, J. T., Fortin, P. R., Ramsey-Goldman, R., Manzi, S., Jönsen, A., Alarcón, G. S., van Vollenhoven C. Aranow M. Mackay, R. F., Ruiz-Irastorza, G., Kalunian, K., Kamen, D. L., and Askanase, A.

Published
2023
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18. Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study

Author

Martins, M, Williams, A H, Comeau, M, Marion, M, Ziegler, J T, Freedman, B I, Merrill, J T, Glenn, S B, Kelly, J A, Sivils, K M, James, J A, Guthridge, J M, Alarcón-Riquelme, M E, Bae, S-C, Kim, J-H, Kim, D, Anaya, J-M, Boackle, S A, Criswell, L A, Kimberly, R P, Alarcón, G S, Brown, E E, Vilá, L M, Petri, M A, Ramsey-Goldman, R, Niewold, T B, Tsao, B P, Gilkeson, G S, Kamen, D L, Jacob, C O, Stevens, A M, Gaffney, P M, Harley, J B, Langefeld, C D, and Fesel, C

Published
2015
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20. Drill-bit upper limit temperature calculation when drilling bones in orthopedic surgery

Author

Tony Boiadjiev, George Boiadjiev, Ivan Chavdarov, Kamen Delchev, and Rumen Kastelov

Subjects
Bone drilling, orthopaedic robot, temperature feedback, upper temperature limit, Biotechnology, TP248.13-248.65
Abstract

The orthopedic manipulation of bone drilling is performed during the osteosynthesis of bone fractures. It is characterized by a set of input and output parameters. The temperature in the tool-bone interaction zone is one of the most important output parameters of the drilling process. The increase in temperature above a certain threshold causes thermal osteonecrosis of bone cells and all the resulting negative consequences. This work presents a way of drill-bit upper limit temperature calculation during robotized bone drilling process. The temperature estimation and temperature calculation methodology is based on the energy conversion in the bone-robot system, preserving the overall energy balance according to the universal energy conservation law. The bone drilling is performed by using of robot ODRO. Fresh porcine femur bones are used as specimens in the experiments which validate the theoretical results. The real time temperature data during drilling are obtained using a non-contact temperature sensor. A computational approach is developed for estimating the temperature in the drilling zone on the base of the obtained data.The temperature estimation data can be used to control of the cutting condition during a robotic bone drilling process in order to obtain an optimal outcome.

Published
2024
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21. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

Author

Wang, S, Adrianto, I, Wiley, G B, Lessard, C J, Kelly, J A, Adler, A J, Glenn, S B, Williams, A H, Ziegler, J T, Comeau, M E, Marion, M C, Wakeland, B E, Liang, C, Kaufman, K M, Guthridge, J M, Alarcón-Riquelme, M E, Alarcón, G S, Anaya, J-M, Bae, S-C, Kim, J-H, Joo, Y B, Boackle, S A, Brown, E E, Petri, M A, Ramsey-Goldman, R, Reveille, J D, Vilá, L M, Criswell, L A, Edberg, J C, Freedman, B I, Gilkeson, G S, Jacob, C O, James, J A, Kamen, D L, Kimberly, R P, Martin, J, Merrill, J T, Niewold, T B, Pons-Estel, B A, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Harley, J B, Wakeland, E K, Moser, K L, Montgomery, C G, and Gaffney, P M

Published
2012
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22. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

Author

Lin, C P, Adrianto, I, Lessard, C J, Kelly, J A, Kaufman, K M, Guthridge, J M, Freedman, B I, Anaya, J-M, Alarcón-Riquelme, M E, Pons-Estel, B A, Martin, J, Glenn, S, Adler, A, Bae, S-C, Park, S-Y, Bang, S-Y, Song, Y-W, Boackle, S A, Brown, E E, Edberg, J C, Alarcón, G S, Petri, M A, Criswell, L A, Ramsey-Goldman, R, Reveille, J D, Vila, L M, Gilkeson, G S, Kamen, D L, Ziegler, J, Jacob, C O, Rasmussen, A, James, J A, Kimberly, R P, Merrill, J T, Niewold, T B, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Moser, K L, Harley, J B, Gaffney, P M, and Montgomery, C G

Published
2012
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23. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

Author

Namjou, B, Kothari, P H, Kelly, J A, Glenn, S B, Ojwang, J O, Adler, A, Alarcón-Riquelme, M E, Gallant, C J, Boackle, S A, Criswell, L A, Kimberly, R P, Brown, E, Edberg, J, Stevens, A M, Jacob, C O, Tsao, B P, Gilkeson, G S, Kamen, D L, Merrill, J T, Petri, M, Goldman, R R, Vila, L M, Anaya, J-M, Niewold, T B, Martin, J, Pons-Estel, B A, Sabio, J M, Callejas, J L, Vyse, T J, Bae, S-C, Perrino, F W, Freedman, B I, Scofield, R H, Moser, K L, Gaffney, P M, James, J A, Langefeld, C D, Kaufman, K M, Harley, J B, and Atkinson, J P

Published
2011
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25. Experimental temperature evaluation during a robotized bone drilling process

Author

Tony Boiadjiev, George Boiadjiev, Nikolay Stoimenov, Kamen Delchev, and Rumen Kastelov

Subjects
Bone drilling, orthopedic robot, temperature evaluation, Biotechnology, TP248.13-248.65
Abstract

AbstractA serious problem associated with orthopedic bone drilling manipulation is the so-called thermal osteonecrosis (TO). This problem occurs because the drilling manipulation generates heat, and the amount of heat depends on the drilling conditions. This work presents the experimental evaluation of the temperature during automated bone drilling by using a handheld Orthopedic bone Drilling Robot ODRO. Up to now, such experimental results related to temperature evaluation in bone drilling by robots have not been presented. Fresh porcine and bovine femur bones were specimens in the experiments. The increase in bone temperature during drilling was measured by a thermal infrared camera. Thermographic sequence images were recorded, processed and visualized using specialized software, which allows to capture accurately the moment of drill bit penetration through the bone and its extraction when going back to initial position. The results showed that under given feed rate and drill speed, when using a new drill bit, the temperature value during porcine femur drilling exceeded the critical threshold of 50 °C for less than 2 s, and thermal osteonecrosis does not occur. When using a worn-out drill bit, the temperature value during bovine femur drilling significantly exceeded the threshold of 50 °C, and thermal osteonecrosis occurs. Thus, to guarantee bone drilling without the risk of thermal osteonecrosis, the automated drilling should be executed with the simultaneous control of speed of drill bit and feed rate. This is possible to be achieved only by robotic execution of the manipulation.

Published
2023
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26. OP0289 LLDAS (LOW LUPUS DISEASE ACTIVITY STATE), LOW DISEASE ACTIVITY (LDA) AND REMISSION (ON- OR OFF-TREATMENT) PREVENT DAMAGE ACCRUAL IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS IN A MULTINATIONAL MULTICENTER COHORT

Author

Ugarte-Gil, M. F., primary, Hanly, J., additional, Urowitz, M. B., additional, Gordon, C., additional, Bae, S. C., additional, Romero-Diaz, J., additional, Sanchez-Guerrero, J., additional, Bernatsky, S., additional, Clarke, A. E., additional, Wallace, D. J., additional, Isenberg, D., additional, Rahman, A., additional, Merrill, J. T., additional, Fortin, P., additional, Gladman, D. D., additional, Bruce, I. N., additional, Petri, M. A., additional, Ginzler, E. M., additional, Dooley, M. A., additional, Ramsey-Goldman, R., additional, Manzi, S., additional, Jonsen, A., additional, Van Vollenhoven, R., additional, Aranow, C., additional, Mackay, M., additional, Ruiz-Irastorza, G., additional, Lim, S. S., additional, Inanc, M., additional, Kalunian, K. C., additional, Jacobsen, S., additional, Peschken, C., additional, Kamen, D. L., additional, Askanase, A., additional, Pons-Estel, B., additional, and Alarcon, G. S., additional

Published
2021
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27. Performance of the EULAR/ACR 2019 classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities

Author

Johnson, S., Brinks, R., Costenbader, K., Daikh, D., Mosca, M., Ramsey-Goldman, R., Smolen, J. S., Wofsy, D., Boumpas, D., Kamen, D. L., Jayne, D., Cervera, R., Costedoat- Chalumeau, N., Diamond, B., Gladman, D. D., Hahn, B. H., Hiepe, F., Jacobsen, S., Khanna, D., Lerstrom, K., Massarotti, E., Mccune, W. J., Ruiz-Irastorza, G., Sanchez-Guerrero, J., Schneider, M., Urowitz, M. B., Bertsias, G., Hoyer, B. F., Leuchten, N., Tani, C., Tedeschi, S., Touma, Z., Schmajuk, G., Anić, Branimir, Assan, F., Chan, T., Clarke, A. E., Crow, M. K., Czirják, L., Doria, A., Graninger, W., Halda- Kiss, B., Hasni, S., Izmirly, P., Jung, M., Kumanovics, G., Mariette, X., Padjen, Ivan, Pego-Reigosa, J. M., Romero-Diaz, J., Rua- Figueroa, I., Seror, R., Stummvoll, G., Tanaka, Y., Tektonidou, M., Vasconcelos, C., Vital, E., Wallace, D. J., Yavuz, S., Meroni, P. L., Fritzler, M., Naden, R., Dörner, T., and Aringer, M.

Subjects
musculoskeletal diseases, immune system diseases, systemic lupus erythematosus, classification criteria, sexes, ethnicities, skin and connective tissue diseases
Abstract

Background: EULAR/ACR 2019 SLE Classification Criteria were validated in an international cohort. Objectives: To evaluate performance characteristics of SLE classification systems in sex, race/ethnicity, and disease duration subsets. Methods: Sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated in the validation cohort. Results: The cohort consisted of female (n=1098), male (n=172), Asian (n=118), Black (n=68), Hispanic (n=124) and White (n=941) patients ; and patients with an SLE duration of 1-3 years (n=196), 3-5 years (n=157), and ≥5 years (n=879). Among patients with 1-3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% (95%CI 92-99%) vs 81% (95%CI 72-88%). The new criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). The new criteria had better sensitivity than the ACR criteria in White (95% vs 83%), Hispanic (100% vs 86%) and Asian patients (97% vs 77%). Conclusion: The EULAR/ACR 2019 criteria perform well in patients with early disease, and across sexes and ethnicities.

Published
2020

28. PERFORMANCE OF THE EULAR/ACR 2019 CLASSIFICATION CRITERIA FOR SYSTEMIC LUPUS ERYTHEMATOSUS IN EARLY DISEASE, ACROSS SEXES AND ETHNICITIES

Author

Johnson, S. Brinks, R. Costenbader, K. Daikh, D. Mosca, M. Ramsey-Goldman, R. Smolen, J. S. Wofsy, D. Boumpas, D. Kamen, D. L. Jayne, D. Cervera, R. and Costedoat-Chalumeau, N. Diamond, B. Gladman, D. D. Hahn, B. H. Hiepe, F. Jacobsen, S. Khanna, D. Lerstrom, K. and Massarotti, E. Mccune, W. J. Ruiz-Irastorza, G. and Sanchez-Guerrero, J. Schneider, M. Urowitz, M. B. Bertsias, G. Hoyer, B. F. Leuchten, N. Tani, C. Tedeschi, S. and Touma, Z. Schmajuk, G. Anic, B. Assan, F. Chan, T. and Clarke, A. E. Crow, M. K. Czirjak, L. Doria, A. and Graninger, W. Halda-Kiss, B. Hasni, S. Izmirly, P. Jung, M. Kumanovics, G. Mariette, X. Padjen, I. Pego-Reigosa, J. M. Romero-Diaz, J. Rua-Figueroa, I. Seror, R. and Stummvoll, G. Tanaka, Y. Tektonidou, M. Vasconcelos, C. and Vital, E. Wallace, D. J. Yavuz, S. Meroni, P. L. and Fritzler, M. Naden, R. Doerner, T. Aringer, M.

Published
2020

33. Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus

Author

Hanly, J G, Urowitz, M B, Su, L, Bae, S-C, Gordon, C, Clarke, A, Bernatsky, S, Vasudevan, A, Isenberg, D, Rahman, A, Wallace, D J, Fortin, P R, Gladman, D, Romero-Dirz, J, Sanchez-Guerrero, J, Dooley, M A, Bruce, I, Steinsson, K, Khamashta, M, Manzi, S, Ramsey-Goldman, R, Sturfelt, G, Nived, O, van Vollenhoven, R, Ramos-Casals, M, Aranow, C, Mackay, M, Kalunian, K, Alarcón, G S, Fessler, B J, Ruiz-Irastorza, G, Petri, M, Lim, S, Kamen, D, Peschken, C, Farewell, V, Thompson, K, Theriault, C, and Merrill, J T

Published
2011
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34. OP0167 SUCCESSFUL WITHDRAWAL OF MYCOPHENOLATE MOFETIL IN QUIESCENT SLE: RESULTS FROM A RANDOMIZED TRIAL

Author

Chakravarty, E., primary, Utset, T., additional, Kamen, D. L., additional, Contreras, G., additional, Mccune, W. J., additional, Kalunian, K. C., additional, Aranow, C., additional, Clowse, M., additional, Goldmuntz, E., additional, Springer, J., additional, Keyes-Elstein, L., additional, Barry, B., additional, Pinckney, A., additional, and James, J., additional

Published
2020
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35. THU0271 PERFORMANCE OF THE EULAR/ACR 2019 CLASSIFICATION CRITERIA FOR SYSTEMIC LUPUS ERYTHEMATOSUS IN EARLY DISEASE, ACROSS SEXES AND ETHNICITIES

Author

Johnson, S., primary, Brinks, R., additional, Costenbader, K., additional, Daikh, D., additional, Mosca, M., additional, Ramsey-Goldman, R., additional, Smolen, J. S., additional, Wofsy, D., additional, Boumpas, D., additional, Kamen, D. L., additional, Jayne, D., additional, Cervera, R., additional, Costedoat-Chalumeau, N., additional, Diamond, B., additional, Gladman, D. D., additional, Hahn, B. H., additional, Hiepe, F., additional, Jacobsen, S., additional, Khanna, D., additional, Lerstrom, K., additional, Massarotti, E., additional, Mccune, W. J., additional, Ruiz-Irastorza, G., additional, Sanchez-Guerrero, J., additional, Schneider, M., additional, Urowitz, M. B., additional, Bertsias, G., additional, Hoyer, B. F., additional, Leuchten, N., additional, Tani, C., additional, Tedeschi, S., additional, Touma, Z., additional, Schmajuk, G., additional, Anic, B., additional, Assan, F., additional, Chan, T., additional, Clarke, A. E., additional, Crow, M. K., additional, Czirják, L., additional, Doria, A., additional, Graninger, W., additional, Halda-Kiss, B., additional, Hasni, S., additional, Izmirly, P., additional, Jung, M., additional, Kumanovics, G., additional, Mariette, X., additional, Padjen, I., additional, Pego-Reigosa, J. M., additional, Romero-Diaz, J., additional, Rua-Figueroa, I., additional, Seror, R., additional, Stummvoll, G., additional, Tanaka, Y., additional, Tektonidou, M., additional, Vasconcelos, C., additional, Vital, E., additional, Wallace, D. J., additional, Yavuz, S., additional, Meroni, P. L., additional, Fritzler, M., additional, Naden, R., additional, Dörner, T., additional, and Aringer, M., additional

Published
2020
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36. THU0253 FATIGUE AND PAIN REMAIN PROMINENT AND IMPACTFUL IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): A CROSS-SECTIONAL SURVEY OF SLE PATIENTS IN THE UNITED STATES

Author

Birt, J., primary, Hadi, M., additional, Sargalo, N., additional, Brookes, E., additional, Swinburn, P., additional, Hanrahan, L., additional, Tse, K., additional, Bello Vega, N., additional, Griffing, K., additional, Silk, M., additional, Delbecque, L., additional, and Kamen, D. L., additional

Published
2020
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38. Anesthetic practice during cardiac implantable electronic device implant procedures: A retrospective, single-center study

Author

Cecilia Veraar, Kamen Dimitrov, Sabine Kappel, Sophie J. Wuthe, Clarence J. Veraar, Arabella Fischer, Isabella Worf, Mohamed Mouhieddine, Luana Mandroiu, Bernhard Moser, N. Patrick Mayr, Cesar Khazen, Edda Tschernko, and Michael J. Hiesmayr

Subjects
Cardiac implantable electronic device, Pacemakers, Implantable cardioverter defibrillators, Anesthetic intervention, Human resources, Anesthetic standby, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objectives: Data on anesthetic proceedings during cardiac implantable electronic device (CIED) implant procedures are scarce and it remains unclear whether anesthetic care is still required in selected patients. Methods: In this retrospective, single center study we assessed the prevalence of intraoperative anesthetic management comprising anesthetic standby, sedation or general anesthesia as well as anesthetic and procedural complications. We analyzed pre-existing and perioperative risk factors related to procedure-related adverse outcome such as perioperative cardiopulmonary resuscitation (CPR) and 30-day mortality in a uni- and multivariable analysis. Results: In total, PM and ICD insertion were performed in up to 85% and 58% under anesthetic standby, with an increasing tendency over time.Overall, Cardiopulmonary resuscitation (CPR) was required in 59 patients. Acute heart failure (AHF) was the only independent pre-existing risk factor for CPR and for 30-day mortality. Sedation and general anesthesia had a significantly increased odds ratio for CPR compared to anesthetic standby. The risk for CPR significantly decreased during the study period. Conclusions: Over the years anesthetic practice during CIED implant procedures shifted from mixed anesthetic proceedings to mainly standby duties. The prevalence of complications and emergency measures is low, however not uncommon. Accordingly, the presence of an anesthesiologist should be further guaranteed when sedatives were titrated and in AHF patients. However, in patients receiving local anesthetic infiltration only, it seems safe to perform CIED implant procedures without anesthetic standby.

Published
2023
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39. Validation of new systemic lupus erythematosus classification criteria

Author

Aringer, M., Costenbader, K.H., Brinks, R., Boumpas, D., Daikh, D., Jayne, D., Kamen, D., Mosca, M., Ramsey-Goldman, R., Smolen, J.S., Wofsy, D., Diamond, B., Jacobsen, S., McCune, W.J., Ruiz-Irastorza, G., Schneider, M., Urowitz, M.B., Bertsias, G., Hoyer, B., Leuchten, N., Tani, C., Tedeschi, S., Touma, Z., Anić, Branimir, Assan, F., Chan, T.M., Clarke, A.E., Crow, M.K., Czírják, L., Doria, A., Graninger, W., Hasni, S., Izmirly, P., Jung, M., Kiss, B., Mariette, X., Padjen, Ivan, Pego- Reigosa, J.M., Romero-Díaz, J., Rúa-Figueroa, I., Seror, R., Stummvoll, G., Tanaka, Y., Tektonidou, M., Vasconcelos, C., Vital, E., Wallace, D.J., Yavuz, S., Naden, R.P., Dörner, T., and Johnson, S.R.

Subjects
musculoskeletal diseases, SLE, classification criteria, immune system diseases, systemic lupus erythematosus, skin and connective tissue diseases
Abstract

Background/Purpose: Correct classification of patients with systemic lupus erythematosus (SLE) is critical for clinical trials and clinical and translational science. The ACR 1997 criteria were criticized for their suboptimal sensitivity. The Systemic Lupus International Cooperating Clinics (SLICC) 2012 criteria increased sensitivity, but at the price of reduced specificity. This and further advances in the field led to the current four phase SLE criteria project. Following an item generation phase and item reduction via a Delphi and a nominal group exercise (1), the provisional criteria were derived from a multicriteria decision analysis exercise (2). These criteria were hence simplified and validated in a large international cohort. Methods: A large international cohort of 2, 321 patients was collected from 23 SLE expert centers, contributing up to 100 patients with SLE and with non-SLE, each. Diagnoses were verified by 3 independent reviewers for 1, 193 SLE and 1, 059 non- SLE patients. 501 randomly selected SLE and 500 non-SLE patients formed the derivation cohort. All other patients with confirmed SLE or non-SLE diagnosis formed the validation cohort. Sensitivity and specificity were compared to the ACR 1997 and the SLICC 2012 criteria. Results: The criteria were fine-tuned and simplified, using ANA of ≥1:80 as entry criterion and a classification threshold of 10. Items can only be counted for classification if there is no more likely cause, and at least one clinical item must be present.

Published
2018

42. Transancestral mapping and genetic load in systemic lupus erythematosus

Author

Langefeld, C. D., Ainsworth, H. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Pons-Estel, Bernardo A., Pope, Janet, Raj, Prithvi, Ramsey-Goldman, Rosalind, Reveille, John D., Russell, Laurie P., Sabio, José Mario, Aguilar-Salinas, Carlos A., Scherbarth, Hugo R., Scorza, Raffaella, Seldin, Michael F., Sjowall, Christopher, Svenungsson, Elisabet, Thompson, Susan D., Toloza, Sergio M. A., Truedsson, Lennart, Tusie-Luna, Teresa, Vasconcelos, C., Vilá, Luis M., Wallace, Daniel J., Weisman, Michael H., Wither, Joan E., Bhangale, Tushar, Oksenberg, Jorge R., Rioux, John D., Gregersen, Peter K., Syvanen, Ann-Christine, Ronnblom, Lars, Criswell, Lindsey A., Jacob, Chaim O., Sivils, Kathy L., Tsao, Betty P., Schanberg, Laura E., Behrens, Timothy W., Silverman, Earl D., Alarcón-Riquelme, M. E., Kimberly, Robert P., Harley, John B., Wakeland, Edward K., Graham, Robert R., Gaffney, P. M., Vyse, Timothy J., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bij, l. M., Brown, E. E., Brunner, H.I., Cardiel, Mario H., Catoggio, Luis, Cervera, Ricard, Cucho-Venegas, Jorge M., Dahlqvist, Solbritt Rantapaa, D'Alfonso, Sandra, Da Silva, Berta Martins, de la Rua Figueroa, Inigo, Doria, Andrea, Edberg, Jeffrey C., Endreffy, Emoke, Esquivel-Valerio, Jorge A., Fortin, Paul R., Freedman, Barry I., Frostegård, Johan, García, Mercedes A., García de la Torre, Ignacio, Gilkeson, G. S., Gladman, Dafna D., Gunnarsson, Iva, Guthridge, Joel M., Huggins, Jennifer L., James, Judith A., Kallenberg, Cees G. M., Kamen, D. L., Karp, David R., Kaufman, Kenneth M, Kottyan, Leah C., Kovacs, Laszlo, Laustrup, Helle, Lauwerys, Bernard R., Li, Quan-Zhen, Maradiaga-Cecena, Marco A., Martín, J., McCune, Joseph M., McWilliams, David R, Merrill, Joan T, Miranda, Pedro, Moctezuma, Jose F., Nath, Swapan K., Niewold, Timothy B., Orozco, Lorena, Ortego-Centeno, N., Petri, Michelle, Pineau, Christian A., National Institute for Health Research (UK), Arthritis Research UK, Alliance for Lupus Research, Junta de Andalucía, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), National Institutes of Health (US), RILITE Foundation, and Genentech Foundation

Subjects
skin and connective tissue diseases
Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE., We gratefully acknowledge the Alliance for Lupus Research for funding and support. The research was supported in part by awards from the Arthritis Research UK Special Strategic Award (ref. 19289) and from George Koukis (T.J.V.). In addition, the research was funded/supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London (T.J.V.). The work would not be possible without funding from the NIH grants AR049084 (RPK, EEB); the International Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN) AI083194 (J.B.H.); CA141700, AR058621 Proyecto de Excelencia, Consejeria de Andalucia (M.E.A.R.); AR043814 and AR-065626 (B.P.T.); AR060366, MD007909, AI107176 (S.K.N.); AR-057172 (C.O.J.); RC2 AR058959, U19 A1082714, R01 AR063124, P30 GM110766, R01 AR056360 (P.M.G.); P60 AR053308 (L.A.C.), MUSC part is from UL1RR029882 (G.S.G., D.L.K.) and 5P60AR062755 (G.S.G., D.L.K., P.R.R.). Oklahoma Samples U19AI082714, U01AI101934, P30GM103510, U54GM104938 and P30AR053483 (J.A.J., J.M.G.); Northwestern P60 AR066464 and 1U54TR001018 (R.R.G.); This study was supported by the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (NIH) under Award Numbers K01 AR067280 and P60 AR062755 (PSR); N01AR22265 (funded collection of APPLE samples) (LES) and the APPLE Investigators; R01AR43727, NIH AR 043727 and 069572 (M.P.); NIAMS/NIH P50-AR055503 (D.R.K.). We would like to also thank the RILITE foundation for financial support (C.D.L.). Additional funding for Immunochip genotyping was provided by Genentech.

Published
2017

44. OP0020 Validation of new systemic lupus erythematosus classification criteria

Author

Aringer, M., primary, Costenbader, K.H., additional, Brinks, R., additional, Boumpas, D., additional, Daikh, D., additional, Jayne, D., additional, Kamen, D., additional, Mosca, M., additional, Ramsey-Goldman, R., additional, Smolen, J.S., additional, Wofsy, D., additional, Diamond, B., additional, Jacobsen, S., additional, McCune, W.J., additional, Ruiz-Irastorza, G., additional, Schneider, M., additional, Urowitz, M.B., additional, Bertsias, G., additional, Hoyer, B., additional, Leuchten, N., additional, Tani, C., additional, Tedeschi, S., additional, Touma, Z., additional, Anic, B., additional, Assan, F., additional, Chan, T.M., additional, Clarke, A.E., additional, Crow, M.K., additional, Czírják, L., additional, Doria, A., additional, Graninger, W., additional, Hasni, S., additional, Izmirly, P., additional, Jung, M., additional, Kiss, B., additional, Mariette, X., additional, Padjen, I., additional, Pego-Reigosa, J.M., additional, Romero-Díaz, J., additional, Rúa-Figueroa, I., additional, Seror, R., additional, Stummvoll, G., additional, Tanaka, Y., additional, Tektonidou, M., additional, Vasconcelos, C., additional, Vital, E., additional, Wallace, D.J., additional, Yavuz, S., additional, Naden, R.P., additional, Dörner, T., additional, and Johnson, S.R., additional

Published
2018
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46. Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients

Author

Isenberg, D., primary, Sturgess, J., additional, Allen, E., additional, Aranow, C., additional, Askanase, A., additional, Sang-Cheol, B., additional, Bernatsky, S., additional, Bruce, I., additional, Buyon, J., additional, Cervera, R., additional, Clarke, A., additional, Dooley, Mary Anne, additional, Fortin, P., additional, Ginzler, E., additional, Gladman, D., additional, Hanly, J., additional, Inanc, M., additional, Jacobsen, S., additional, Kamen, D., additional, Khamashta, M., additional, Lim, S., additional, Manzi, S., additional, Nived, O., additional, Peschken, C., additional, Petri, M., additional, Kalunian, K., additional, Rahman, A., additional, Ramsey-Goldman, R., additional, Romero-Diaz, J., additional, Ruiz-Irastorza, G., additional, Sanchez-Guerrero, J., additional, Steinsson, K., additional, Sturfelt, G., additional, Urowitz, M., additional, van Vollenhoven, R., additional, Wallace, D. J., additional, Zoma, A., additional, Merrill, J., additional, and Gordon, C., additional

Published
2017
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48. Breast cancer in systemic lupus

Author

Bernatsky, S., Ramsey-Goldman, R., Petri, M., Urowitz, M. B., Gladman, D. D., Fortin, P. F., Ginzler, E., Romero-Diaz, J., Peschken, C., Jacobsen, S., Hanly, J. G., Gordon, C., Nived, O., Yelin, E. H., Isenberg, D., Rahman, A., Bae, S. C., Joseph, L., Witte, T., Ruiz-Irastorza, G., Aranow, C., Kamen, D., Sturfeldt, G., Foulkes, W. D., Hansen, J. E., St Pierre, Y., Raymer, P. Chrétien, Tessier-Cloutier, B., Clarke, A. E., Bernatsky, S., Ramsey-Goldman, R., Petri, M., Urowitz, M. B., Gladman, D. D., Fortin, P. F., Ginzler, E., Romero-Diaz, J., Peschken, C., Jacobsen, S., Hanly, J. G., Gordon, C., Nived, O., Yelin, E. H., Isenberg, D., Rahman, A., Bae, S. C., Joseph, L., Witte, T., Ruiz-Irastorza, G., Aranow, C., Kamen, D., Sturfeldt, G., Foulkes, W. D., Hansen, J. E., St Pierre, Y., Raymer, P. Chrétien, Tessier-Cloutier, B., and Clarke, A. E.

Abstract

Objective There is a decreased breast cancer risk in systemic lupus erythematosus (SLE) versus the general population. We assessed a large sample of SLE patients, evaluating demographic and clinical characteristics and breast cancer risk. Methods We performed case-cohort analyses within a multi-center international SLE sample. We calculated the breast cancer hazard ratio (HR) in female SLE patients, relative to demographics, reproductive history, family history of breast cancer, and time-dependent measures of anti-dsDNA positivity, cumulative disease activity, and drugs, adjusted for SLE duration. Results There were 86 SLE breast cancers and 4498 female SLE cancer-free controls. Patients were followed on average for 7.6 years. Versus controls, SLE breast cancer cases tended to be white and older. Breast cancer cases were similar to controls regarding anti-dsDNA positivity, disease activity, and most drug exposures over time. In univariate and multivariate models, the principal factor associated with breast cancers was older age at cohort entry. Conclusions There was little evidence that breast cancer risk in this SLE sample was strongly driven by any of the clinical factors that we studied. Further search for factors that determine the lower risk of breast cancer in SLE may be warranted.

Published
2017

49. Transancestral mapping and genetic load in systemic lupus erythematosus

Author

National Institute for Health Research (UK), Arthritis Research UK, Alliance for Lupus Research, Junta de Andalucía, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), National Institutes of Health (US), RILITE Foundation, Genentech Foundation, Langefeld, C. D., Ainsworth, H. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Pons-Estel, Bernardo A., Pope, Janet, Raj, Prithvi, Ramsey-Goldman, Rosalind, Reveille, John D., Russell, Laurie P., Sabio, José Mario, Aguilar-Salinas, Carlos A., Scherbarth, Hugo R., Scorza, Raffaella, Seldin, Michael F., Sjowall, Christopher, Svenungsson, Elisabet, Thompson, Susan D., Toloza, Sergio M. A., Truedsson, Lennart, Tusie-Luna, Teresa, Vasconcelos, C., Vilá, Luis M., Wallace, Daniel J., Weisman, Michael H., Wither, Joan E., Bhangale, Tushar, Oksenberg, Jorge R., Rioux, John D., Gregersen, Peter K., Syvanen, Ann-Christine, Ronnblom, Lars, Criswell, Lindsey A., Jacob, Chaim O., Sivils, Kathy L., Tsao, Betty P., Schanberg, Laura E., Behrens, Timothy W., Silverman, Earl D., Alarcón-Riquelme, M. E., Kimberly, Robert P., Harley, John B., Wakeland, Edward K., Graham, Robert R., Gaffney, P. M., Vyse, Timothy J., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bij, l. M., Brown, E. E., Brunner, H.I., Cardiel, Mario H., Catoggio, Luis, Cervera, Ricard, Cucho-Venegas, Jorge M., Dahlqvist, Solbritt Rantapaa, D'Alfonso, Sandra, Da Silva, Berta Martins, de la Rua Figueroa, Inigo, Doria, Andrea, Edberg, Jeffrey C., Endreffy, Emoke, Esquivel-Valerio, Jorge A., Fortin, Paul R., Freedman, Barry I., Frostegård, Johan, García, Mercedes A., García de la Torre, Ignacio, Gilkeson, G. S., Gladman, Dafna D., Gunnarsson, Iva, Guthridge, Joel M., Huggins, Jennifer L., James, Judith A., Kallenberg, Cees G. M., Kamen, D. L., Karp, David R., Kaufman, Kenneth M, Kottyan, Leah C., Kovacs, Laszlo, Laustrup, Helle, Lauwerys, Bernard R., Li, Quan-Zhen, Maradiaga-Cecena, Marco A., Martín, J., McCune, Joseph M., McWilliams, David R, Merrill, Joan T, Miranda, Pedro, Moctezuma, Jose F., Nath, Swapan K., Niewold, Timothy B., Orozco, Lorena, Ortego-Centeno, N., Petri, Michelle, Pineau, Christian A., National Institute for Health Research (UK), Arthritis Research UK, Alliance for Lupus Research, Junta de Andalucía, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), National Institutes of Health (US), RILITE Foundation, Genentech Foundation, Langefeld, C. D., Ainsworth, H. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Pons-Estel, Bernardo A., Pope, Janet, Raj, Prithvi, Ramsey-Goldman, Rosalind, Reveille, John D., Russell, Laurie P., Sabio, José Mario, Aguilar-Salinas, Carlos A., Scherbarth, Hugo R., Scorza, Raffaella, Seldin, Michael F., Sjowall, Christopher, Svenungsson, Elisabet, Thompson, Susan D., Toloza, Sergio M. A., Truedsson, Lennart, Tusie-Luna, Teresa, Vasconcelos, C., Vilá, Luis M., Wallace, Daniel J., Weisman, Michael H., Wither, Joan E., Bhangale, Tushar, Oksenberg, Jorge R., Rioux, John D., Gregersen, Peter K., Syvanen, Ann-Christine, Ronnblom, Lars, Criswell, Lindsey A., Jacob, Chaim O., Sivils, Kathy L., Tsao, Betty P., Schanberg, Laura E., Behrens, Timothy W., Silverman, Earl D., Alarcón-Riquelme, M. E., Kimberly, Robert P., Harley, John B., Wakeland, Edward K., Graham, Robert R., Gaffney, P. M., Vyse, Timothy J., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bij, l. M., Brown, E. E., Brunner, H.I., Cardiel, Mario H., Catoggio, Luis, Cervera, Ricard, Cucho-Venegas, Jorge M., Dahlqvist, Solbritt Rantapaa, D'Alfonso, Sandra, Da Silva, Berta Martins, de la Rua Figueroa, Inigo, Doria, Andrea, Edberg, Jeffrey C., Endreffy, Emoke, Esquivel-Valerio, Jorge A., Fortin, Paul R., Freedman, Barry I., Frostegård, Johan, García, Mercedes A., García de la Torre, Ignacio, Gilkeson, G. S., Gladman, Dafna D., Gunnarsson, Iva, Guthridge, Joel M., Huggins, Jennifer L., James, Judith A., Kallenberg, Cees G. M., Kamen, D. L., Karp, David R., Kaufman, Kenneth M, Kottyan, Leah C., Kovacs, Laszlo, Laustrup, Helle, Lauwerys, Bernard R., Li, Quan-Zhen, Maradiaga-Cecena, Marco A., Martín, J., McCune, Joseph M., McWilliams, David R, Merrill, Joan T, Miranda, Pedro, Moctezuma, Jose F., Nath, Swapan K., Niewold, Timothy B., Orozco, Lorena, Ortego-Centeno, N., Petri, Michelle, and Pineau, Christian A.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.

Published
2017

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