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3. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, De Piero, Maria Elena, Mariani, Silvia, Di Mauro, Michele, Folliguet, Thierry, Taccone, Fabio Silvio, Camporota, Luigi, Swol, Justyna, Wiedemann, Dominik, Belliato, Mirko, Broman, Lars Mikael, Vuylsteke, Alain, Kassif, Yigal, Scandroglio, Anna Mara, Fanelli, Vito, Gaudard, Philippe, Ledot, Stephane, Barker, Julian, Boeken, Udo, Maier, Sven, Kersten, Alexander, Meyns, Bart, Pozzi, Matteo, Pedersen, Finn M, Schellongowski, Peter, Kirali, Kaan, Barrett, Nicholas, Riera, Jordi, Mueller, Thomas, Belohlavek, Jan, Lo Coco, Valeria, Van der Horst, Iwan C C, Van Bussel, Bas C T, Schnabel, Ronny M, Delnoij, Thijs, Bolotin, Gil, Lorini, Luca, Schmiady, Martin O, Schibilsky, David, Kowalewski, Mariusz, Pinto, Luis F, Silva, Pedro E, Kornilov, Igor, Blandino Ortiz, Aaron, Vercaemst, Leen, Finney, Simon, Roeleveld, Peter P, Di Nardo, Matteo, Hennig, Felix, Antonini, Marta Velia, Davidson, Mark, Jones, Tim J, Staudinger, Thomas, Mair, Peter, Kilo, Juliane, Krapf, Christoph, Erbert, Kathrin, Peer, Andreas, Bonaros, Nikolaos, Kotheletner, Florian, Krenner Mag, Niklas, Shestakova, Liana, Hermans, Greet, Dauwe, Dieter, Meersseman, Philippe, Stockman, Bernard, Nobile, Leda, Lhereux, Olivier, Nrasseurs, Alexandre, Creuter, Jacques, De Backer, Daniel, Giglioli, Simone, Michiels, Gregoire, Foulon, Pierre, Raes, Matthias, Rodrigus, Inez, Allegaert, Matthias, Jorens, Philippe, Debeucklare, Gerd, Piagnerelli, Michael, Biston, Patrick, Peperstraete, Harlinde, Vandewiele, Komeel, Germay, Olivier, Vandeweghe, Dimitri, Havrin, Sven, Bourgeois, Marc, Lagny, Marc-Gilbert, Alois, Genette, Lavios, Nathalie, Misset, Benoit, Courcelle, Romain, Timmermans, Philippe J, Yilmaz, Alaaddin, Vantomout, Michiel, Lehaen, Jerone, Jassen, Ame, Guterman, Herbert, Strauven, Maarten, Lormans, Piet, Verhamme, Bruno, Vandewaeter, catherine, Bonte, Frederik, Vionne, Dominique, Balik, Martin, Blàha, Jan, Lips, Michal, Othal, Michal, Bursa, Filip, Spacek, Radim, Christensen, Steffen, Jorgensen, Vibeke, Sorensen, Marc, Madsen, Soren A, Puss, Severin, Beljantsev, Aleksandr, Saiydoun, gabriel, Fiore, Antonio, Colson, Pascal, Bazalgette, Florian, Capdevila, Xavier, Kollen, Sebastien, Muller, Laurent, Obadia, Jean-Francois, Dubien, Pierre-Yves, Ajrhourh, Lucrezia, Guinot, Pierre G, Zarka, Jonathan, Besserve, Patricia, Malfertheiner, Maximilian V, Dreier, Esther, Heinze, Birgit, Akhyari, Payam, Lichtenberg, Artur, Aubin, Hug, Assman, Alexander, Saeed, Diyar, Thiele, Holger, Baumgaertel, Matthias, Schmitto, Jan D, Ruslan, Natanov, Haverich, Axel, Thielmann, Matthias, Brenner, Thorsten, Ruhpawar, Arjang, Benk, Christoph, Czerny, Martin, Staudacher, Dawid L, Beyersdorf, Fridhelm, Kalbhenn, Johannes, Henn, Philipp, Popov, Aron-Frederik, Iuliu, Torje, Muellenbach, Ralf, Reyher, Christian, Rolfes, Caroline, Lotz, Gosta, Sonntagbauer, Michael, Winkels, Helen, Fichte, Julia, Stohr, Robert, Kalverkamp, Sebastian, Karagiannidis, Christian, Schafer, Simone, Svetlitchny, Alexei, Hopf, Hans-Bernd, Jarczak, Dominik, Groesdonk, Heinirich, Rommer, Magdalena, Hirsch, Jan, Kaehny, Christian, Soufleris, Dimitros, Gavriilidis, Georgios, Pontikis, Kostantinos, Kyriakopoulou, Magdalini, Kyriakoudi, Anna, O'Brien, Serena, Conrick-Martin, Ian, Carton, Edmund, Makhoul, Maged, Ben-Ari, Josef, Hadash, Amir, Kogan, Alexander, Kassif Lerner, Reut, Abu-Shakra, Anas, Matan, Moshe, Balawona, Ahmad, Kachel, Erez, Altshuler, Roman, Galante, Ori, Fuchs, Lior, Almog, Yaniv, Ishay, Yaron S, Lichter, Yael, Gal-oz, Amir, Carmi, Uri, Nini, Asaph, Soroksky, Arie, Dekel, Hagi, Rozman, Ziv, Tayem, Emad, Ilgiyaev, Eduard, Hochman, Yuval, Miltau, daniel, Rapoport, Avigal, Eden, Arieh, Kompanietz, Dmitry, Yousif, Michael, Golos, Miri, Grazioli, Lorenzo, Ghitti, Davide, Loforte, Antonio, Di Luca, Daniela, Baiocchi, Massimo, Pacini, Davide, Cappai, Antioco, Meani, Paolo, Mondino, Michele, Russo, Claudio F, Ranucci, Marco, Fina, Dario, Cotza, Marco, Ballotta, Andrea, Landoni, Giovanni, Nardelli, Pasquale, Fominski, Eygeny V, Brazzi, Luca, Montrucchio, Giorgia, Sales, Gabriele, Simonetti, Umberto, Livigni, Sergio, Silengo, Daniela, Arena, Giulia, Sovatzis, Stefania S, Degani, Antonella, Riccardi, Mariachiara, Milanesi, Elisa, Raffa, Giuseppe, Martucci, Gennaro, Arcadipane, Antonio, Panarello, Giovanna, Chiarini, Giovanni, Cattaneo, Sergio, Puglia, Carmine, Benussi, Stefano, Foti, Giuseppe, Giani, Marco, Bombino, Michela, Costa, Maria Cristina, Rona, Roberto, Avalli, Leonello, Donati, Abele, Carozza, Roberto, Gasparri, Francesco, Carsetti, Andrea, Picichè, Marco, Marinello, Anna, Danzi, Vinicio, Zanin, Anita, Condello, Ignazio, Fiore, Flavio, Moscarelli, Marco, Nasso, Giuseppe, Speziale, Giuseppe, Sandrelli, Luca, Montalto, Andrea, Musumeci, Francesco, Circelli, Alessandro, Russo, Emanuele, Agnoletti, Vanni, Rociola, Ruggero, Milano, Aldo D, Pilato, Emanuele, Comentale, Giuseppe, Montisci, Andrea, Alessandri, Francesco, Tosi, Antonella, Pugliese, Francesco, Giordano, Giovanni, Carelli, Simone, Grieco, Domenico L, Dell'Anna, Antonio M, Antonelli, Massimo, Ramoni, Enrico, Zulueta, Josè, Del Giglio, Mauro, Petracca, Sebastiano, Bertini, Pietro, Guarracino, Fabio, De Simone, Luigi, Angeletti, Paolo M, Forfori, Francesco, Taraschi, Francesco, Quintiliani, Veronica N, Samalavicius, Robertas, Jankuviene, Agne, Scupakova, Nadezda, Urbonas, Karolis, Kapturauskas, Juozas, Soerensen, Gro, Suwalski, Piotr, Linhares Santos, Luis, Marques, Ana, Miranda, Marisa, Teixeira, Sonia, Salgueiro, Andrea, Pereira, Filipe, Ketskalo, Michail, Tsarenko, Sergey, Shilova, Alexandra, Afukov, Ivan, Popugaev, Konstantin, Minin, Sergei, Shelukhin, Daniil, Malceva, Olga, Gleb, Moroz, Skopets, Alexander, Kornelyuk, Roman, Kulikov, Alexandr, Okhrimchuk, Vadim, Turchaninov, Alexandr, Petrushin, Maxim, Sheck, Anastasia, Mekulov, Akhmed, Ciryateva, Svetlana, Urusov, Dmitry, Gorjup, Vojka, Golicnik, Alenka, Goslar, Tomaz, Ferrer, Ricard, Martinez-Martinez, Maria, Argudo, Eduard, Palmer, Neiser, De Pablo Sanchez, Raul, Juan Higuera, Lucas, Arnau Blasco, Lucas, Marquez, Josè A, Sbraga, Fabrizio, Fuset, Mari Paz, De Gopegui, Pablo Ruiz, Claraco, Luis M, De Ayala, Josè A, Peiro, Maranta, Ricart, Pilar, Martinez, Sergio, Chavez, Fernando, Fabra, Marc, Sandoval, elena, Toapanta, David, Carraminana, Albert, Tellez, Adrian, Ososio, Jeysson, Milan, Pablo, Rodriguez, Jorge, Andoni, Garcia, Gutierrez, Carola, Perez de la Sota, Enrique, Eixeres-Esteve, Andrea, Garcia-Maellas, Maria Teresa, Gutierrez-Gutierrez, Judit, Arboleda-Salazar, Rafael, Santa Teresa, Patricia, Jaspe, Alexis, Garrido, Alberto, Castaneda, Galo, Alcantara, Sara, Martinez, Nuria, Perez, Marina, Villanueva, Hector, Vidal Gonzalez, Anxela, Paez, Juan, Santon, Arnoldo, Perez, Cesar, Lopez, Marta, Rubio Lopez, Maria Isabel, Gordillo, Antonio, Naranjo-Izurieta, Jose, Munoz, Javier, Alcalde, Immaculada, Onieva, Fernando, Gimeno Costa, Ricardo, Perez, Francisco, Madrid, Isabel, Gordon, Monica, Albacete Moreno, Carlos L, Perez, Daniel, Lopez, Nayara, Martinenz, Domingo, Blanco-Schweizer, Pablo, Diez, Cristina, Perez, David, Prieto, Ana, Renedo, Gloria, Bustamante, Elena, Cicuendez, Ramon, Citores, Rafael, Boado, Victoria, Garcia, Katherine, Voces, Roberto, Domezain, Monica, Nunez Martinez, Jose Maria, Vicente, Raimundo, Martin, David, Andreu, Antonio, Gomez Casal, Vanesa, Chico, Ignacio, Menor, Eva Maria, Vara, Sabela, Gamacho, Jose, Perez-Chomon, Helen, Javier Gonzales, Francisco, Barrero, Irene, Martin-Villen, Luis, Fernandez, Esperanza, Mendoza, Maria, Navarro, Joaquin, Colomina Climent, Joaquin, Gonzales-Perez, Alfredo, Muniz-Albaceita, Guillermo, Amado, Laura, Rodriguez, Raquel, Ruiz, Emilio, Eiras, Maria, Grins, Edgars, Magnus, Rosen, Kanetoft, Mikael, Eidevald, Marcus, Watson, Pia, Vogt, Paul R, Steiger, Peter, Aigner, Tobias, Weber, Alberto, Grunefelder, Jurg, Kunz, Martin, Grapow, Martin, Aymard, Thierry, Reser, Diana, Agus, Gianluca, Consiglio, Jolanda, Haenggi, Matthias, Hansjoerg, Jenni, Iten, Manuela, Doeble, Thomas, Zenklusen, Urs, Bechtold, Xavier, Faedda, Giovanni, Iafrate, Manuel, Rohjer, Amanda, Bergamaschi, Layla, Maessen, Jos, Reis Miranda, Dinis, Endeman, H, Gommers, D, Meuwese, C, Maas, Jacinta, Van Gijlswijk, MJ, Van Berg, RN, Candura, Dario, Van der Linden, Marcel, Kant, Merijin, Van der Heijden, JJ, Scholten, Eric, Van Belle-van Haren, Nicole, Lagrand, WK, Vlaar, Alexander P, De Jong, Syste, Cander, Basar, Sargin, Murat, Ugur, Murat, Kaygin, Mehmet A, Daly, Kathleen, Agnew, Nicola, Head, Laura, Kelly, Laura, Anoma, Gunawardena, Russell, Clare, Aquino, Verna, Scott, Ian, Flemming, Lucy, Gillon, Stuart, Moore, Olivia, Gelandt, Elton, Auzinger, George, Patel, Sameer, and Loveridge, Robert

Published
2023
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4. Diagnostische und therapeutische Prozeduren

Author

Herdtle, Steffen, primary, Kalverkamp, Sebastian, additional, Kiefl, Daniel, additional, Kraemer, Anja, additional, Kummer, Lars, additional, Ottomeyer, Caroline, additional, Schramm, Christoph, additional, and Stock, Christian, additional

Published
2023
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5. Adressen

Author

Sauer, Dorothea, primary, Herdtle, Steffen, additional, Kiefl, Daniel, additional, Bardonicsek-Depnering, Zsofia, additional, Baumgartner, Ingrid, additional, Becker, Tobias, additional, Beißert, Malte, additional, Bernhard, Michael, additional, Böhm, Lennert, additional, Borgmann, Thomas, additional, Bruns, Tony, additional, Bürger, Martin, additional, Bürkner, Andreas, additional, Casu, Sebastian, additional, Dehina, Nora, additional, Dinse-Lambracht, Alexander, additional, Fischbach, Andreas, additional, Fries, Janna, additional, Glauner, Till, additional, Kalverkamp, Sebastian, additional, Kill, Clemens, additional, Kostek, Lisanne, additional, Kraemer, Anja, additional, Kummer, Lars, additional, Lenska-Mathar, Christoph, additional, Mayer, Katharina, additional, Mertens, Peter, additional, Michael, Mark, additional, Michels, Guido, additional, Miller, Julia, additional, Müller-Nolte, Patrick, additional, Nemetz, Sebastian, additional, Netou-Kandylidou, Zoi, additional, Ottomeyer, Caroline, additional, Paulun, Annika, additional, Petscher, Matthias, additional, Plappert, Thomas, additional, Poetzsch, Marian, additional, Reschke, Kirsten, additional, Riße, Joachim, additional, Schramm, Christoph, additional, Schürmann, Jutta, additional, Stock, Christian, additional, Stolz, Gregor, additional, Strauß, Dagmar, additional, Ullrich, Greta, additional, Wiebe, Beatrix, additional, and Witt, Ulrike, additional

Published
2023
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7. In vitro evaluation of the performance of an oxygenator depending on the non-standard gas content of the inlet blood with special regard on CO2 elimination.

Author

Hima, Flutura, Saunders, Amalia, Kashefi, Ali, Mouzakis, Foivos, Mottaghy, Khosrow, Spillner, Jan, Zayat, Rachad, and Kalverkamp, Sebastian

Subjects
OXYGEN metabolism, BLOOD gases analysis, IN vitro studies, SWINE, BIOLOGICAL models, COMPUTER simulation, PULMONARY gas exchange, RESEARCH funding, OXYGENATORS, DESCRIPTIVE statistics, PHYSIOLOGICAL transport of oxygen, BLOOD circulation, CARBON dioxide, DATA analysis software
Abstract

Introduction: The performance of an oxygenator, as found in literature, is evaluated according to protocols that define standard values of the gas content in the inlet blood. However, when dealing with simulations of lung insufficiency, a more extensive evaluation is needed. This work aims to investigate and assess the gas exchange performance of an oxygenator for different input values of gas content in blood. Methods: Three commercially available oxygenators with different membrane surfaces were investigated in a mock loop for three blood flow rates (0.5l/min, 1l/min, and 5l/min) and two gas-to-blood ratios (1:1, and 15:1). The initial CO2 and O2 partial pressures (pCO2 and pO2) in blood were set to ≥ 100 mmHg and ≤10 mmHg, respectively. For each ratio, the efficiency, defined as the ratio between the difference of pressure inlet and outlet and the inlet pCO2 (pCO2(i)), was calculated. Results: The CO2 elimination in an oxygenator was higher for higher pCO2(i). While for a pCO2(i) of 100 mmHg, an oxygenator eliminated 80 mmHg, the same oxygenator at the same conditions eliminated 5 mmHg CO2 when pCO2(i) was 10 mmHg. The efficiency of the oxygenator decreased from 76,9% to 49,5%. For simulation reasons, the relation between the pCO2(i) and outlet (pCO2(o)) for each oxygenator at different blood and gas flows, was described as an exponential formula. Conclusion: The performance of an oxygenator in terms of CO2 elimination depends not only on the blood and gas flow, but also on the initial pCO2 value. This dependence is crucial for simulation studies in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Apical Sparing of Longitudinal Strain as a Specific Pattern of Myocardial Fibrosis in Patients with Severe Left Ventricular Hypertrophy: A Comparison between Deformation Imaging and Histological Findings.

Author

Yelenski, Siarhei, Zayat, Rashad, Spillner, Jan, Donuru, Srinath Reddy, Kolashov, Alish, Khattab, Mohammad Amen, Hatam, Nima, and Kalverkamp, Sebastian

Subjects
SPECKLE tracking echocardiography, VENTRICULAR septum, AORTIC valve transplantation, LOGISTIC regression analysis, HYPERTROPHIC cardiomyopathy, LEFT ventricular hypertrophy
Abstract

Objectives: This study aimed to investigate the correlation between apical sparing of longitudinal strain (LS), as measured by speckle-tracking echocardiography (STE), and the histological presence of myocardial fibrosis (MF), in patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods: Twenty-seven HOCM patients who underwent elective Morrow procedures +/− aortic valve replacement (AVR) were included. All patients had standard echocardiography, with STE pre- and post-operatively. Intraoperative probes of the interventricular septum were sent for histological analysis. Correlation of different regional LS patterns with the histological findings of MF and with clinical outcome were analyzed. In addition, a logistic regression and ROC analysis were performed. Results: All patients underwent the Morrow procedure for HOCM, with 33.3% also undergoing AVR. A total of 74.1% showed evidence of MF in the histological analysis. Patients with MF had significantly lower GLS than patients without MF (−12.7 ± 2.7% vs. −23.0 ± 5.7%, p < 0.001). The LS in patients with MF was significantly lower at the basal regions of the LV segments and increased significantly towards the apex as compared to the patients without MF (mean basal-strain %: −10.6 ± 2.6 vs. −17.3 ± 4.6, p < 0.001; mean apical strain %: −21.8 ± 4.8 vs. −16.7 ± 5.6, p = 0.032). In the logistic regression, only the GLS remained as an independent predictor of MF with an Odds ratio of 1.07 (95%-CI: 1.05–1.09, p < 0.001). Conclusions: Our study highlights the significant correlation between GLS and MF in HOCM patients. These findings contribute to the growing understanding of MF in HOCM and may inform future approaches to patient management and risk stratification. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Adressen

Author

Kraemer, Anja, primary, Beyer, Wolfgang, additional, Brosch, Stephan, additional, Franz, Cordula, additional, Heidbrink, Kirsten, additional, Högenauer, Hanna, additional, Hurlemann, René, additional, Kalverkamp, Sebastian, additional, Kiehn, Barbara, additional, Koitschev, Assen, additional, Moritz, Rudolf, additional, genannt Schroeder, Norbert Neißkenwirth, additional, Paulun, Annika, additional, Schacher, Sylvia, additional, Starke, Kathrin, additional, Wiebe, Beatrix, additional, de Pilar, Marieke Pilars, additional, Rüdiger, Nermin, additional, and Schmitz-Rode, Christoph, additional

Published
2021
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12. De Ritis Ratio to Predict Clinical Outcomes of Intermediate- and High-Risk Pulmonary Embolisms.

Author

Durak, Koray, Nubbemeyer, Katharina, Zayat, Rashad, Spillner, Jan, Dineva, Slavena, Kalverkamp, Sebastian, and Kersten, Alexander

Subjects
PULMONARY embolism, EXTRACORPOREAL membrane oxygenation, TREATMENT effectiveness, ALANINE aminotransferase, ASPARTATE aminotransferase
Abstract

Background: Abnormal liver function tests can identify severe cardiopulmonary failure. The aspartate transaminase/alanine transaminase (AST/ALT) ratio, or the De Ritis ratio, is commonly used to evaluate acute liver damage. However, its prognostic value in pulmonary embolism (PE) is unknown. Methods: Two cohorts, including patients with intermediate- and high-risk PEs, were established: one with an abnormal baseline AST/ALT ratio (>1) and another with a normal baseline AST/ALT ratio (<1). The primary outcome was a 60-day mortality. Secondary outcomes included peak N-terminal pro-brain-natriuretic-peptide (NT-proBNP) levels, complications, and the need for critical care treatment. To assess the effect of abnormal AST/ALT ratios, inverse probability weighted (IPW) analyses were performed. Results: In total, 230 patients were included in the analysis, and 52 (23%) had an abnormal AST/ALT ratio. After the IPW correction, patients with an abnormal AST/ALT ratio had a significantly higher mortality rate and peak NT-proBNP levels. The relative risks of 60-day mortality, shock development, use of inotropes/vasopressors, mechanical ventilation, and extracorporeal life support were 9.2 (95% confidence interval: 3.3–25.3), 10.1 (4.3–24), 2.7 (1.4–5.2), 2.3 (1.4–3.7), and 5.7 (1.4–23.1), respectively. Conclusions: The baseline AST/ALT ratio can be a predictor of shock, multiorgan failure, and mortality in patients with a pulmonary embolism. [ABSTRACT FROM AUTHOR]

Published
2024
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16. sj-pdf-1-jao-10.1177_03913988231168163 – Supplemental material for Oxygenation performance assessment of an artificial lung in different central anatomic configurations

Author

Hima, Flutura, Kalverkamp, Sebastian, Kashefi, Ali, Mottaghy, Khosrow, Zayat, Rachad, Strudthoff, Lasse, Spillner, Jan, and Mouzakis, Foivos

Subjects
FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-jao-10.1177_03913988231168163 for Oxygenation performance assessment of an artificial lung in different central anatomic configurations by Flutura Hima, Sebastian Kalverkamp, Ali Kashefi, Khosrow Mottaghy, Rachad Zayat, Lasse Strudthoff, Jan Spillner and Foivos Mouzakis in The International Journal of Artificial Organs

Published
2023
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21. Adressen

Author

Kraemer, Anja, primary, Beyer, Wolfgang, additional, Brosch, Stephan, additional, Franz, Cordula, additional, Heidbrink, Kirsten, additional, Högenauer, Hanna, additional, Hurlemann, René, additional, Huseynov, Elvin, additional, Kalverkamp, Sebastian, additional, Kiehn, Barbara, additional, Moritz, Rudolf, additional, Neißkenwirth, Norbert, additional, Paulun, Annika, additional, de Pilar, Marieke Pilars, additional, Rüdiger, Nermin, additional, Schmitz-Rode, Christoph, additional, Starke, Kathrin, additional, Tsoukakis, Ioannis, additional, Wiebe, Beatrix, additional, Benecke, Claudia, additional, Benecke, Peter, additional, Calero, Luis, additional, Liebetrau, Ulrich, additional, Manista, Klaudia, additional, Miese, Anja, additional, Mohns, Thilo, additional, Nehring, Barbara, additional, Sielk, Martin, additional, and Theile-Ochel, Susanne, additional

Published
2018
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23. Computational fluid dynamics analysis of endoluminal aortic perfusion.

Author

Malinowski, Daniel, Fournier, Yvan, Horbach, Andreas, Frick, Michael, Magliani, Mirko, Kalverkamp, Sebastian, Hildinger, Martin, Spillner, Jan, Behbahani, Mehdi, and Hima, Flutura

Subjects
COMPUTER simulation, THORACIC aorta, EXTRACORPOREAL membrane oxygenation, MAGNETIC resonance imaging, OXYGEN saturation, BLOOD circulation, HEMODYNAMICS, PERFUSION, BLOOD flow measurement
Abstract

Introduction: In peripheral percutaneous (VA) extracorporeal membrane oxygenation (ECMO) procedures the femoral arteries perfusion route has inherent disadvantages regarding poor upper body perfusion due to watershed. With the advent of new long flexible cannulas an advancement of the tip up to the ascending aorta has become feasible. To investigate the impact of such long endoluminal cannulas on upper body perfusion, a Computational Fluid Dynamics (CFD) study was performed considering different support levels and three cannula positions. Methods: An idealized literature-based- and a real patient proximal aortic geometry including an endoluminal cannula were constructed. The blood flow was considered continuous. Oxygen saturation was set to 80% for the blood coming from the heart and to 100% for the blood leaving the cannula. 50% and 90% venoarterial support levels from the total blood flow rate of 6 l/min were investigated for three different positions of the cannula in the aortic arch. Results: For both geometries, the placement of the cannula in the ascending aorta led to a superior oxygenation of all aortic blood vessels except for the left coronary artery. Cannula placements at the aortic arch and descending aorta could support supra-aortic arteries, but not the coronary arteries. All positions were able to support all branches with saturated blood at 90% flow volume. Conclusions: In accordance with clinical observations CFD analysis reveals, that retrograde advancement of a long endoluminal cannula can considerably improve the oxygenation of the upper body and lead to oxygen saturation distributions similar to those of a central cannulation. [ABSTRACT FROM AUTHOR]

Published
2023
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25. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, primary, De Piero, Maria Elena, additional, Mariani, Silvia, additional, Di Mauro, Michele, additional, Folliguet, Thierry, additional, Taccone, Fabio Silvio, additional, Camporota, Luigi, additional, Swol, Justyna, additional, Wiedemann, Dominik, additional, Belliato, Mirko, additional, Broman, Lars Mikael, additional, Vuylsteke, Alain, additional, Kassif, Yigal, additional, Scandroglio, Anna Mara, additional, Fanelli, Vito, additional, Gaudard, Philippe, additional, Ledot, Stephane, additional, Barker, Julian, additional, Boeken, Udo, additional, Maier, Sven, additional, Kersten, Alexander, additional, Meyns, Bart, additional, Pozzi, Matteo, additional, Pedersen, Finn M, additional, Schellongowski, Peter, additional, Kirali, Kaan, additional, Barrett, Nicholas, additional, Riera, Jordi, additional, Mueller, Thomas, additional, Belohlavek, Jan, additional, Lorusso, Roberto, additional, Lo Coco, Valeria, additional, Van der Horst, Iwan C C, additional, Van Bussel, Bas C T, additional, Schnabel, Ronny M, additional, Delnoij, Thijs, additional, Bolotin, Gil, additional, Lorini, Luca, additional, Schmiady, Martin O, additional, Schibilsky, David, additional, Kowalewski, Mariusz, additional, Pinto, Luis F, additional, Silva, Pedro E, additional, Kornilov, Igor, additional, Blandino Ortiz, Aaron, additional, Vercaemst, Leen, additional, Finney, Simon, additional, Roeleveld, Peter P, additional, Di Nardo, Matteo, additional, Hennig, Felix, additional, Antonini, Marta Velia, additional, Davidson, Mark, additional, Jones, Tim J, additional, Staudinger, Thomas, additional, Mair, Peter, additional, Kilo, Juliane, additional, Krapf, Christoph, additional, Erbert, Kathrin, additional, Peer, Andreas, additional, Bonaros, Nikolaos, additional, Kotheletner, Florian, additional, Krenner Mag, Niklas, additional, Shestakova, Liana, additional, Hermans, Greet, additional, Dauwe, Dieter, additional, Meersseman, Philippe, additional, Stockman, Bernard, additional, Nobile, Leda, additional, Lhereux, Olivier, additional, Nrasseurs, Alexandre, additional, Creuter, Jacques, additional, De Backer, Daniel, additional, Giglioli, Simone, additional, Michiels, Gregoire, additional, Foulon, Pierre, additional, Raes, Matthias, additional, Rodrigus, Inez, additional, Allegaert, Matthias, additional, Jorens, Philippe, additional, Debeucklare, Gerd, additional, Piagnarelli, Michael, additional, Biston, Patrick, additional, Peperstraete, Harlinde, additional, Vandewiele, Komeel, additional, Germay, Olivier, additional, Vandeweghe, Dimitri, additional, Havrin, Sven, additional, Bourgeois, Marc, additional, Lagny, Marc-Gilbert, additional, Alois, Genette, additional, Lavios, Nathalie, additional, Misset, Benoit, additional, Courcelle, Romain, additional, Timmermans, Philippe J, additional, Yilmaz, Alaaddin, additional, Vantomout, Michiel, additional, Lehaen, Jerone, additional, Jassen, Ame, additional, Guterman, Herbert, additional, Strauven, Maarten, additional, Lormans, Piet, additional, Verhamme, Bruno, additional, Vandewaeter, catherine, additional, Bonte, Frederik, additional, Vionne, Dominique, additional, Balik, Martin, additional, Blàha, Jan, additional, Lips, Michal, additional, Othal, Michal, additional, Bursa, Filip, additional, Spacek, Radim, additional, Christensen, Steffen, additional, Jorgensen, Vibeke, additional, Sorensen, Marc, additional, Madsen, Soren A, additional, Puss, Severin, additional, Beljantsev, Aleksandr, additional, Saiydoun, gabriel, additional, Fiore, Antonio, additional, Colson, Pascal, additional, Bazalgette, Florian, additional, Capdevila, Xavier, additional, Kollen, Sebastien, additional, Muller, Laurent, additional, Obadia, Jean-Francois, additional, Dubien, Pierre-Yves, additional, Ajrhourh, Lucrezia, additional, Guinot, Pierre G, additional, Zarka, Jonathan, additional, Besserve, Patricia, additional, Malfertheiner, Maximilian V, additional, Dreier, Esther, additional, Heinze, Birgit, additional, Akhyari, Payam, additional, Lichtenberg, Artur, additional, Aubin, Hug, additional, Assman, Alexander, additional, Saeed, Diyar, additional, Thiele, Holger, additional, Baumgaertel, Matthias, additional, Schmitto, Jan D, additional, Ruslan, Natanov, additional, Haverich, Axel, additional, Thielmann, Matthias, additional, Brenner, Thorsten, additional, Ruhpawar, Arjang, additional, Benk, Christoph, additional, Czerny, Martin, additional, Staudacher, Dawid L, additional, Beyersdorf, Fridhelm, additional, Kalbhenn, Johannes, additional, Henn, Philipp, additional, Popov, Aron-Frederik, additional, Iuliu, Torje, additional, Muellenbach, Ralf, additional, Reyher, Christian, additional, Rolfes, Caroline, additional, Lotz, Gosta, additional, Sonntagbauer, Michael, additional, Winkels, Helen, additional, Fichte, Julia, additional, Stohr, Robert, additional, Kalverkamp, Sebastian, additional, Karagiannidis, Christian, additional, Schafer, Simone, additional, Svetlitchny, Alexei, additional, Hopf, Hans-Bernd, additional, Jarczak, Dominik, additional, Groesdonk, Heinirich, additional, Rommer, Magdalena, additional, Hirsch, Jan, additional, Kaehny, Christian, additional, Soufleris, Dimitros, additional, Gavriilidis, Georgios, additional, Pontikis, Kostantinos, additional, Kyriakopoulou, Magdalini, additional, Kyriakoudi, Anna, additional, O'Brien, Serena, additional, Conrick-Martin, Ian, additional, Carton, Edmund, additional, Makhoul, Maged, additional, Ben-Ari, Josef, additional, Hadash, Amir, additional, Kogan, Alexander, additional, Kassif Lerner, Reut, additional, Abu-Shakra, Anas, additional, Matan, Moshe, additional, Balawona, Ahmad, additional, Kachel, Erez, additional, Altshuler, Roman, additional, Galante, Ori, additional, Fuchs, Lior, additional, Almog, Yaniv, additional, Ishay, Yaron S, additional, Lichter, Yael, additional, Gal-oz, Amir, additional, Carmi, Uri, additional, Nini, Asaph, additional, Soroksky, Arie, additional, Dekel, Hagi, additional, Rozman, Ziv, additional, Tayem, Emad, additional, Ilgiyaev, Eduard, additional, Hochman, Yuval, additional, Miltau, daniel, additional, Rapoport, Avigal, additional, Eden, Arieh, additional, Kompanietz, Dmitry, additional, Yousif, Michael, additional, Golos, Miri, additional, Grazioli, Lorenzo, additional, Ghitti, Davide, additional, Loforte, Antonio, additional, Di Luca, Daniela, additional, Baiocchi, Massimo, additional, Pacini, Davide, additional, Cappai, Antioco, additional, Meani, Paolo, additional, Mondino, Michele, additional, Russo, Claudio F, additional, Ranucci, Marco, additional, Fina, Dario, additional, Cotza, Marco, additional, Ballotta, Andrea, additional, Landoni, Giovanni, additional, Nardelli, Pasquale, additional, Fominski, Eygeny V, additional, Brazzi, Luca, additional, Montrucchio, Giorgia, additional, Sales, Gabriele, additional, Simonetti, Umberto, additional, Livigni, Sergio, additional, Silengo, Daniela, additional, Arena, Giulia, additional, Sovatzis, Stefania S, additional, Degani, Antonella, additional, Riccardi, Mariachiara, additional, Milanesi, Elisa, additional, Raffa, Giuseppe, additional, Martucci, Gennaro, additional, Arcadipane, Antonio, additional, Panarello, Giovanna, additional, Chiarini, Giovanni, additional, Cattaneo, Sergio, additional, Puglia, Carmine, additional, Benussi, Stefano, additional, Foti, Giuseppe, additional, Giani, Marco, additional, Bombino, Michela, additional, Costa, Maria Cristina, additional, Rona, Roberto, additional, Avalli, Leonello, additional, Donati, Abele, additional, Carozza, Roberto, additional, Gasparri, Francesco, additional, Carsetti, Andrea, additional, Picichè, Marco, additional, Marinello, Anna, additional, Danzi, Vinicio, additional, Zanin, Anita, additional, Condello, Ignazio, additional, Fiore, Flavio, additional, Moscarelli, Marco, additional, Nasso, Giuseppe, additional, Speziale, Giuseppe, additional, Sandrelli, Luca, additional, Montalto, Andrea, additional, Musumeci, Francesco, additional, Circelli, Alessandro, additional, Russo, Emanuele, additional, Agnoletti, Vanni, additional, Rociola, Ruggero, additional, Milano, Aldo D, additional, Pilato, Emanuele, additional, Comentale, Giuseppe, additional, Montisci, Andrea, additional, Alessandri, Francesco, additional, Tosi, Antonella, additional, Pugliese, Francesco, additional, Giordano, Giovanni, additional, Carelli, Simone, additional, Grieco, Domenico L, additional, Dell'Anna, Antonio M, additional, Antonelli, Massimo, additional, Ramoni, Enrico, additional, Zulueta, Josè, additional, Del Giglio, Mauro, additional, Petracca, Sebastiano, additional, Bertini, Pietro, additional, Guarracino, Fabio, additional, De Simone, Luigi, additional, Angeletti, Paolo M, additional, Forfori, Francesco, additional, Taraschi, Francesco, additional, Quintiliani, Veronica N, additional, Samalavicius, Robertas, additional, Jankuviene, Agne, additional, Scupakova, Nadezda, additional, Urbonas, Karolis, additional, Kapturauskas, Juozas, additional, Soerensen, Gro, additional, Suwalski, Piotr, additional, Linhares Santos, Luis, additional, Marques, Ana, additional, Miranda, Marisa, additional, Teixeira, Sonia, additional, Salgueiro, Andrea, additional, Pereira, Filipe, additional, Ketskalo, Michail, additional, Tsarenko, Sergey, additional, Shilova, Alexandra, additional, Afukov, Ivan, additional, Popugaev, Konstantin, additional, Minin, Sergei, additional, Shelukhin, Daniil, additional, Malceva, Olga, additional, Gleb, Moroz, additional, Skopets, Alexander, additional, Kornelyuk, Roman, additional, Kulikov, Alexandr, additional, Okhrimchuk, Vadim, additional, Turchaninov, Alexandr, additional, Petrushin, Maxim, additional, Sheck, Anastasia, additional, Mekulov, Akhmed, additional, Ciryateva, Svetlana, additional, Urusov, Dmitry, additional, Gorjup, Vojka, additional, Golicnik, Alenka, additional, Goslar, Tomaz, additional, Ferrer, Ricard, additional, Martinez-Martinez, Maria, additional, Argudo, Eduard, additional, Palmer, Neiser, additional, De Pablo Sanchez, Raul, additional, Juan Higuera, Lucas, additional, Arnau Blasco, Lucas, additional, Marquez, Josè A, additional, Sbraga, Fabrizio, additional, Fuset, Mari Paz, additional, De Gopegui, Pablo Ruiz, additional, Claraco, Luis M, additional, De Ayala, Josè A, additional, Peiro, Maranta, additional, Ricart, Pilar, additional, Martinez, Sergio, additional, Chavez, Fernando, additional, Fabra, Marc, additional, Sandoval, elena, additional, Toapanta, David, additional, Carraminana, Albert, additional, Tellez, Adrian, additional, Ososio, Jeysson, additional, Milan, Pablo, additional, Rodriguez, Jorge, additional, Andoni, Garcia, additional, Gutierrez, Carola, additional, Perez de la Sota, Enrique, additional, Eixeres-Esteve, Andrea, additional, Garcia-Maellas, Maria Teresa, additional, Gutierrez-Gutierrez, Judit, additional, Arboleda-Salazar, Rafael, additional, Santa Teresa, Patricia, additional, Jaspe, Alexis, additional, Garrido, Alberto, additional, Castaneda, Galo, additional, Alcantara, Sara, additional, Martinez, Nuria, additional, Perez, Marina, additional, Villanueva, Hector, additional, Vidal Gonzalez, Anxela, additional, Paez, Juan, additional, Santon, Arnoldo, additional, Perez, Cesar, additional, Lopez, Marta, additional, Rubio Lopez, Maria Isabel, additional, Gordillo, Antonio, additional, Naranjo-Izurieta, Jose, additional, Munoz, Javier, additional, Alcalde, Immaculada, additional, Onieva, Fernando, additional, Gimeno Costa, Ricardo, additional, Perez, Francisco, additional, Madrid, Isabel, additional, Gordon, Monica, additional, Albacete Moreno, Carlos L, additional, Perez, Daniel, additional, Lopez, Nayara, additional, Martinenz, Domingo, additional, Blanco-Schweizer, Pablo, additional, Diez, Cristina, additional, Perez, David, additional, Prieto, Ana, additional, Renedo, Gloria, additional, Bustamante, Elena, additional, Cicuendez, Ramon, additional, Citores, Rafael, additional, Boado, Victoria, additional, Garcia, Katherine, additional, Voces, Roberto, additional, Domezain, Monica, additional, Nunez Martinez, Jose Maria, additional, Vicente, Raimundo, additional, Martin, David, additional, Andreu, Antonio, additional, Gomez Casal, Vanesa, additional, Chico, Ignacio, additional, Menor, Eva Maria, additional, Vara, Sabela, additional, Gamacho, Jose, additional, Perez-Chomon, Helen, additional, Javier Gonzales, Francisco, additional, Barrero, Irene, additional, Martin-Villen, Luis, additional, Fernandez, Esperanza, additional, Mendoza, Maria, additional, Navarro, Joaquin, additional, Colomina Climent, Joaquin, additional, Gonzales-Perez, Alfredo, additional, Muniz-Albaceita, Guillermo, additional, Amado, Laura, additional, Rodriguez, Raquel, additional, Ruiz, Emilio, additional, Eiras, Maria, additional, Grins, Edgars, additional, Magnus, Rosen, additional, Kanetoft, Mikael, additional, Eidevald, Marcus, additional, Watson, Pia, additional, Vogt, Paul R, additional, Steiger, Peter, additional, Aigner, Tobias, additional, Weber, Alberto, additional, Grunefelder, Jurg, additional, Kunz, Martin, additional, Grapow, Martin, additional, Aymard, Thierry, additional, Reser, Diana, additional, Agus, Gianluca, additional, Consiglio, Jolanda, additional, Haenggi, Matthias, additional, Hansjoerg, Jenni, additional, Iten, Manuela, additional, Doeble, Thomas, additional, Zenklusen, Urs, additional, Bechtold, Xavier, additional, Faedda, Giovanni, additional, Iafrate, Manuel, additional, Rohjer, Amanda, additional, Bergamaschi, Layla, additional, Maessen, Jos, additional, Reis Miranda, Dinis, additional, Endeman, H, additional, Gommers, D, additional, Meuwese, C, additional, Maas, Jacinta, additional, Van Gijlswijk, MJ, additional, Van Berg, RN, additional, Candura, Dario, additional, Van der Linden, Marcel, additional, Kant, Merijin, additional, Van der Heijden, JJ, additional, Scholten, Eric, additional, Van Belle-van Haren, Nicole, additional, Lagrand, WK, additional, Vlaar, Alexander P, additional, De Jong, Syste, additional, Cander, Basar, additional, Sargin, Murat, additional, Ugur, Murat, additional, Kaygin, Mehmet A, additional, Daly, Kathleen, additional, Agnew, Nicola, additional, Head, Laura, additional, Kelly, Laura, additional, Anoma, Gunawardena, additional, Russell, Clare, additional, Aquino, Verna, additional, Scott, Ian, additional, Flemming, Lucy, additional, Gillon, Stuart, additional, Moore, Olivia, additional, Gelandt, Elton, additional, Auzinger, George, additional, Patel, Sameer, additional, and Loveridge, Robert, additional

Published
2022
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28. Supplemental Material - Computational fluid dynamics analysis of endoluminal aortic perfusion

Author

Malinowski, Daniel, Fournier, Yvan, Horbach, Andreas, Frick, Michael, Magliani, Mirko, Kalverkamp, Sebastian, Hildinger, Martin, Spillner, Jan, Behbahani, Mehdi, and Hima, Flutura

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemetary Material for Computational fluid dynamics analysis of endoluminal aortic perfusion by Daniel Malinowski, Yvan Fournier, Andreas Horbach, Michael Frick, Mirko Magliani, Sebastian Kalverkamp, Martin Hildinger, Jan Spillner, Mehdi Behbahani and Flutura Hima in Perfusion

Published
2022
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32. Outcomes of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome in COVID-19 Patients: A Propensity-Matched Analysis

Author

Autschbach, Teresa, primary, Hatam, Nima, additional, Durak, Koray, additional, Grottke, Oliver, additional, Dreher, Michael, additional, Nubbemeyer, Katharina, additional, Rossaint, Rolf, additional, Marx, Gernot, additional, Marx, Nikolaus, additional, Spillner, Jan, additional, Zayat, Rashad, additional, Kalverkamp, Sebastian, additional, and Kersten, Alex, additional

Published
2021
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35. Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca2+-sensitisation.

Author

Rieg, Annette D., Suleiman, Said, Anker, Carolin, Bünting, Nina A., Verjans, Eva, Spillner, Jan, Kalverkamp, Sebastian, von Stillfried, Saskia, Braunschweig, Till, Uhlig, Stefan, and Martin, Christian

Subjects
PLATELET-derived growth factor, IDIOPATHIC pulmonary fibrosis, PROTEIN-tyrosine kinase inhibitors, POLYMERIZATION, ACTIN
Abstract

Background: PDGFR-inhibition by the tyrosine kinase inhibitor (TKI) nintedanib attenuates the progress of idiopathic pulmonary fibrosis (IPF). However, the effects of PDGF-BB on the airway tone are almost unknown. We studied this issue and the mechanisms beyond, using isolated perfused lungs (IPL) of guinea pigs (GPs) and precision-cut lung slices (PCLS) of GPs and humans.Methods: IPL: PDGF-BB was perfused after or without pre-treatment with the TKI imatinib (perfused/nebulised) and its effects on the tidal volume (TV), the dynamic compliance (Cdyn) and the resistance were studied.Pcls (gp): The bronchoconstrictive effects of PDGF-BB and the mechanisms beyond were evaluated. PCLS (human): The bronchoconstrictive effects of PDGF-BB and the bronchorelaxant effects of imatinib were studied. All changes of the airway tone were measured by videomicroscopy and indicated as changes of the initial airway area.Results: PCLS (GP/human): PDGF-BB lead to a contraction of airways. IPL: PDGF-BB decreased TV and Cdyn, whereas the resistance did not increase significantly. In both models, inhibition of PDGFR-(β) (imatinib/SU6668) prevented the bronchoconstrictive effect of PDGF-BB. The mechanisms beyond PDGF-BB-induced bronchoconstriction include activation of MAP2K and TP-receptors, actin polymerisation and Ca2+-sensitisation, whereas the increase of Ca2+ itself and the activation of EP1-4-receptors were not of relevance. In addition, imatinib relaxed pre-constricted human airways.Conclusions: PDGFR regulates the airway tone. In PCLS from GPs, this regulatory mechanism depends on the β-subunit. Hence, PDGFR-inhibition may not only represent a target to improve chronic airway disease such as IPF, but may also provide acute bronchodilation in asthma. Since asthma therapy uses topical application. This is even more relevant, as nebulisation of imatinib also appears to be effective. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Prolonged Survival of a Patient with Advanced-Stage Combined Hepatocellular-Cholangiocarcinoma

Author

Loosen, Sven H., primary, Gaisa, Nadine T., additional, Schmeding, Maximilian, additional, Heining, Christoph, additional, Uhrig, Sebastian, additional, Wirtz, Theresa H., additional, Kalverkamp, Sebastian, additional, Spillner, Jan, additional, Tacke, Frank, additional, Stenzinger, Albrecht, additional, Glimm, Hanno, additional, Fröhling, Stefan, additional, Trautwein, Christian, additional, Roderburg, Christoph, additional, Longerich, Thomas, additional, Neumann, Ulf Peter, additional, and Luedde, Tom, additional

Published
2020
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40. Levosimendan reduces segmental pulmonary vascular resistance in isolated perfused rat lungs and relaxes human pulmonary vessels

Author

Rieg, Annette Dorothea, primary, Suleiman, Said, additional, Bünting, Nina Andrea, additional, Verjans, Eva, additional, Spillner, Jan, additional, Schnöring, Heike, additional, Kalverkamp, Sebastian, additional, Schröder, Thomas, additional, von Stillfried, Saskia, additional, Braunschweig, Till, additional, Schälte, Gereon, additional, Uhlig, Stefan, additional, and Martin, Christian, additional

Published
2020
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43. Role of extracorporeal membrane oxygenation in critically Ill COVID‐19 patients and predictors of mortality.

Author

Zayat, Rashad, Kalverkamp, Sebastian, Grottke, Oliver, Durak, Koray, Dreher, Michael, Autschbach, Rüdiger, Marx, Gernot, Marx, Nikolaus, Spillner, Jan, and Kersten, Alex

Subjects
*COVID-19, *EXTRACORPOREAL membrane oxygenation, *FORECASTING, *CRITICALLY ill, *DEATH forecasting, *OXYGENATORS
Abstract

The role of extracorporeal membrane oxygenation (ECMO) in the management of critically ill COVID‐19 patients remains unclear. Our study aims to analyze the outcomes and risk factors from patients treated with ECMO. This retrospective, single‐center study includes 17 COVID‐19 patients treated with ECMO. Univariate and multivariate parametric survival regression identified predictors of survival. Nine patients (53%) were successfully weaned from ECMO and discharged. The incidence of in‐hospital mortality was 47%. In a univariate analysis, only four out of 83 pre‐ECMO variables were significantly different; IL‐6, PCT, and NT‐proBNP were significantly higher in non‐survivors than in survivors. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score was significantly higher in survivors. After a multivariate parametric survival regression, IL‐6, NT‐proBNP and RESP scores remained significant independent predictors, with hazard ratios (HR) of 1.069 [95%‐CI: 0.986‐1.160], P =.016 1.001 [95%‐CI: 1.000‐1.001], P =.012; and.843 [95%‐CI: 0.564‐1.260], P =.040, respectively. A prediction model comprising IL‐6, NT‐proBNP, and RESP score showed an area under the curve (AUC) of 0.87, with a sensitivity of 87.5% and 77.8% specificity compared to an AUC of 0.79 for the RESP score alone. The present study suggests that ECMO is a potentially lifesaving treatment for selected critically ill COVID‐19 patients. Considering IL‐6 and NT‐pro‐BNP, in addition to the RESP score, may enhance outcome predictions. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Argon reduces the pulmonary vascular tone in rats and humans by GABA-receptor activation

Author

Suleiman, Said, primary, Klassen, Sergej, additional, Katz, Ira, additional, Balakirski, Galina, additional, Krabbe, Julia, additional, von Stillfried, Saskia, additional, Kintsler, Svetlana, additional, Braunschweig, Till, additional, Babendreyer, Aaron, additional, Spillner, Jan, additional, Kalverkamp, Sebastian, additional, Schröder, Thomas, additional, Moeller, Manfred, additional, Coburn, Mark, additional, Uhlig, Stefan, additional, Martin, Christian, additional, and Rieg, Annette D., additional

Published
2019
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46. A New Percutaneous Approach to Treat Combined Right Ventricular and Respiratory Failure: The "Aachen Cannula".

Author

Hima, Flutura, Gümmer, Marjolijn, Prescher, Andreas, Altarawneh, Bader, Zayat, Rachad, Hatam, Nima, Ernst, Lisa, Kalverkamp, Sebastian, Spillner, Jan, and Arias-Pinilla, Jessica

Subjects
RESPIRATORY insufficiency, CATHETERS, LUNG diseases, HEART failure
Abstract

Introduction: Right ventricular failure (RVF) on its own is a life-threatening condition. Often it manifests as a two-organ failure in the final phase of several lung diseases. Mechanical circulatory support is a proven treatment of RVF but remains challenging. Our objective is to develop a novel, simplified, and minimally invasive cannula approach to treat both RVF and respiratory failure. Methods: We conceptualized a dual lumen cannula approach to allow oxygenated right-to-left shunting at an atrial level to decompress right-sided circulation. A minimally invasive approach through percutaneous, transjugular insertion and transseptal placement should enable patients to be non-sedated and even ambulatory. In an iterative design, pre-prototyping, prototyping, and anatomic fitting process, such a cannula was generated and tested in both cadaveric and fluid dynamic studies. Results: After various modifications and improvements, a 27-Fr 255-mm-long double-lumen cannula with an inner line (oxygenated blood return to patient into the left atrium) of 18 Fr and an inflatable balloon (with a volume of approximately 1 mL) at the outflow tip was produced – one version with a straight head and another one with a curved head. In our anatomic studies, the "Aachen Cannula" allowed an easy transjugular introduction and advancement into the right atrium by Seldinger technique. Transseptal placement was achieved by puncture (Brockenbrough needle) in combination with dilatation and was then secured in place with the stabilizing balloon, even under slight tension. The cannula prototype enabled a flow of up to 3.5 L/min, at which common pressure drops were observed. Conclusion: In conclusion, we successfully conceptualized, designed, and verified a minimally invasive one-cannula approach for the treatment of either isolated right heart failure and even combined RVF and respiratory failure through our transseptal Aachen Cannula. This concept may also be carried out in ambulatory conditions. Moreover, this approach completely avoids recirculation issues and ensures reliable oxygenated coronary as well as cerebral perfusion. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Low concentration of phenol in medical solutions can induce bronchoconstriction and toxicity in murine, rat and human lungs.

Author

Balakirski, Galina, primary, Krabbe, Julia, additional, Schettgen, Thomas, additional, Rieg, Annette, additional, Schröder, Thomas, additional, Spillner, Jan, additional, Kalverkamp, Sebastian, additional, Braunschweig, Till, additional, Kintsler, Svetlana, additional, Krüger, Ingo, additional, Breuer, Elisabeth, additional, and Martin, Christian, additional

Published
2018
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