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2. A Systematic Study of the Prevalence and Risk Factors of CKD in Uddanam, India

Author

Gummidi, Balaji, John, Oommen, Ghosh, Arpita, Modi, Gopesh K., Sehgal, Meena, Kalra, Om P., Kher, Vijay, Muliyil, Jayaprakash, Thakur, Jarnail S., Ramakrishnan, Lakshmy, Pandey, Chandra M., Sivakumar, Vishnubhotla, Dhaliwal, Rupinder S., Khanna, Tripti, Kumari, Aruna, Prasadini, Geetha, Reddy, Janardhan C., Reddy, Jawahar, and Jha, Vivekanand

Published
2020
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6. Chronic Kidney Disease of Unknown Etiology in India: What Do We Know and Where We Need to Go

Author

John, Oommen, Gummudi, Balaji, Jha, Anubhuti, Gopalakrishnan, Natarajan, Kalra, Om P., Kaur, Prabhdeep, Kher, Vijay, Kumar, Vivek, Machiraju, Ravi Shankar, Osborne, Nicolas, Palo, Subrata Kumar, Parameswaran, Sreejith, Pati, Sanghamitra, Prasad, Narayan, Rathore, Vinay, Rajapurkar, Mohan M., Sahay, Manisha, Tatapudi, Ravi Raju, Thakur, Jarnail S., Venugopal, Vidhya, and Jha, Vivekanand

Published
2021
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11. Study to Test and Operationalize Preventive Approaches for CKD of Undetermined Etiology in Andhra Pradesh, India

Author

John, Oommen, primary, Gummidi, Balaji, additional, Tewari, Abha, additional, Muliyil, J.P., additional, Ghosh, Arpita, additional, Sehgal, Meena, additional, Bassi, Abhinav, additional, Prinja, Shankar, additional, Kumar, Vivek, additional, Kalra, Om P., additional, Kher, Vijay, additional, Thakur, J.S., additional, Ramakrishnan, Lakshmy, additional, Pandey, C.M., additional, Sivakumar, V., additional, Dhaliwal, R.S., additional, Khanna, Tripti, additional, Kumari, Aruna, additional, Sharma, Jitender, additional, Malakondiah, Poonam, additional, and Jha, Vivekanand, additional

Published
2019
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16. The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An in silico analysis

Author

Gurudutta Gangenahalli U, Pati Soumya, Kalra Om P, and Mukhopadhyay Asok

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Stem cell factor (SCF) receptor c-Kit is recognized as a key signaling molecule, which transduces signals for the proliferation, differentiation and survival of stem cells. Binding of SCF to its receptor triggers transactivation, leading to the recruitment of kinases and phosphatases to the docking platforms of c-Kit catalytic domain. Tyrosine phosphatase-1 (Shp-1) deactivates/attenuates 'Kit' kinase activity. Whereas, Asp816Val mutation in the Kit activation loop transforms kinase domain to a constitutively activated state (switch off-to-on state), in a ligand-independent manner. This phenomenon completely abrogates negative regulation of Shp-1. To predict the possible molecular basis of interaction between c-Kit and Shp-1, we have performed an in silico protein-protein docking study between crystal structure of activated c-Kit (phosphorylated c-Kit) and full length crystal structure of Shp-2, a close structural counterpart of Shp-1. Findings Study revealed a stretch of conserved amino acids (Lys818 to Ser821) in the Kit activation domain, which makes decisive H-bonds with N-sh2 and phosphotyrosine binding pocket residues of the phosphatase. These H-bonds may impose an inhibitory steric hindrance to the catalytic domain of c-Kit, there by blocking further interaction of the activation loop molecules with incoming kinases. We have also predicted a phosphotyrosine binding pocket in SH2 domains of Shp-1, which is found to be predominantly closer to a catalytic groove like structure in c-Kit kinase domain. Conclusions This study predicts that crucial hydrogen bonding between N-sh2 domain of Shp-1 and Kit activation loop can modulate the negative regulation of c-Kit kinase by Shp-1. Thus, this finding is expected to play a significant role in designing suitable gain-of-function c-Kit mutants for inducing conditional proliferation of hematopoietic stem cells.

Published
2010
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21. Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients

Author

Aggarwal, Neerja, primary, Kare, Pawan Kumar, additional, Varshney, Parul, additional, Kalra, Om Prakash, additional, Madhu, Sri Venkata, additional, Banerjee, Basu Dev, additional, Yadav, Anil, additional, Raizada, Alpana, additional, and Tripathi, Ashok Kumar, additional

Published
2017
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49. The 2014 Academic College of Emergency Experts in India's Education Development Committee (EDC) White Paper on establishing an academic department of Emergency Medicine in India - Guidelines for Staffing, Infrastructure, Resources, Curriculum and Training

Author

Aggarwal, Praveen, Galwankar, Sagar, Kalra, Om Prakash, Bhalla, Ashish, Bhoi, Sanjeev, and Sundarakumar, Sundarajan

Subjects
EMERGENCY medicine, EMERGENCY medical services, EMERGENCY medical personnel, MEDICAL personnel -- Services for, MEDICAL care, EDUCATION
Abstract

Emergency medicine services and training in Emergency Medicine (EM) has developed to a large extent in developed countries but its establishment is far from optimal in developing countries. In India, Medical Council of India (MCI) has taken great steps by notifying EM as a separate specialty and so far 20 medical colleges have already initiated 3-year training program in EM. However, there has been shortage of trained faculty, and ambiguity regarding curriculum, rotation policy, infrastructure, teachers' eligibility qualifications and scheme of examination. Academic College of Emergency Experts in India (ACEE-India) has been a powerful advocate for developing Academic EM in India. The ACEE's Education Development Committee (EDC) was created to chalk out guidelines for staffing, infrastructure, resources, curriculum, and training which may be of help to the MCI and the National Board of Examinations (NBE) to set standards for starting 3-year training program in EM and develop the departments of EM as centers of quality education, research, and treatment across India. This paper has made an attempt to give recommendations so as to provide a uniform framework to the institutions, thus guiding them towards establishing an academic Department of EM for starting the 3-year training program in the specialty of EM. [ABSTRACT FROM AUTHOR]

Published
2014
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50. Role of neutrophil gelatinase-associated lipocalin for early detection of acute kidney injury.

Author

Sanjeevani, Scienthia, Pruthi, Sonal, Kalra, Sarathi, Goel, Ashish, and Kalra, Om Prakash

Subjects
NEUTROPHILS, LIPOCALINS, ACUTE kidney failure, CYSTATINS, POINT-of-care testing
Abstract

Acute kidney injury (AKI) is characterized by abrupt or rapid decline of renal function and is usually associated with the development of serious complications as well as an independent risk of mortality in hospitalized patients. Emergency physicians play a critical role in recognizing early AKI, preventing iatrogenic injury, and reversing the course of AKI. Among the various available biomarkers for AKI, reliable and automated assay methods are commercially available for only cystatin-C and neutrophil gelatinase-associated lipocalin (NGAL). NGAL appears to be a promising marker for early detection of AKI and is likely to be adapted for wide-scale clinical use in patient management as a point-of-care test. Use of NGAL along with panel of other renal biomarkers can improve the rate of early detection of AKI. Large, multicenter studies demonstrate the association between biomarkers and hard end points such as need for renal replacement therapy (RRT), cardiovascular events, hospital stay, and death, independent of serum creatinine concentrations. [ABSTRACT FROM AUTHOR]

Published
2014
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