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10. Abortion

Author

Kalousek, Dagmar K., Fitch, Naomi, Paradice, Barbara A., Kalousek, Dagmar K., Fitch, Naomi, and Paradice, Barbara A.

Published
1990
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31. Colaboradores

Author

Eisenstat, David D., Wigle, Jeffrey T., Chudley, Albert E., Narvey, Michael, Ahing, Steve, Antoniazzi, Franco, Araujo, Edward, Jr., Barringer, Dean, Danzinger, Marnie, Becker, Volker, Been, J.V., Benacerraf, Beryl, Bhatnagar, Kunwar, Bolender, David, Borges Peixoto, Alberto, Branco Ferreira, Mario João, Cleghorn, Blaine M., Golarz De Bourne, M.N., Dean, Heather, Del Bigio, Marc, Fanos, Vassilios, Fernandes Rodrigues, João Carlos, Gaillard, Frank, Geddes, Gary, Grayson, Barry H., Vendittelli, Bruno L., Harman, Christopher R., Hay, Jean, Henderson, Blair, Hill, Lyndon M., Hinrichsen, Klaus V., Jackson, Jon, Jackson, Margaret, Jain, Evelyn, Jane, John A., Sr, Jordan, Robert, Juretschke, Linda J., Kalousek, Dagmar K., Klatt, E.C., Lee, Wesley, Levine, Deborah, (Ted) Lyons, E.A., Morris, Margaret, Morrison, Stuart C., Mulliken, John B., Jerry Oakes, W., Parkinson, Dwight, Patel, Maulik S., Phillips, Susan, Ramachandra, Srinivasa, Ray, M., Reed, Martin H., Reid, Gregory J., Michele Rice, Michael, Robben, S.G., Sahni, Prem S., Velasco Sanchez, Marcos Antonio, Schuurman, M.J., Schwartz, P., Michelmann, H.M., Siebert, Joseph R., Smith, Bradley R., Smyser, Gerald S., Soucy, Pierre, Suzuki, Y., Shane Tubbs, R., Uthman, Edward O., Vassilis, Zoumpourlis, Wiseman, Nathan E., and Zenzes, M.T.

Published
2020
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32. Comparative Genomic Hybridization A New Tool for Reproductive Pathology

Author

Barrett, Irene J., Lomax, Brenda L., Loukianova, Tatiana, Tang, Steven S., Lestou, Valia S., and Kalousek, Dagmar K.

Subjects
Hybridization -- Research, Medical genetics -- Research, Reproductive technology -- Research
Abstract

Objective.--To demonstrate the effectiveness of comparative genomic hybridization (CGH) for analysis of reproductive pathology specimens in clinical cytogenetics laboratories. Design.--A total of 856 CGH analyses were performed on various placental and fetal tissues derived from 368 specimens of spontaneous abortions and on placentas from 219 pregnancies with live-born infants. The live-born infants were clinically evaluated as normally developed, with either a normal birth weight or with intrauterine growth restriction; some live-born infants had an abnormal prenatal triple screen with normal cytogenetic results on amniotic fluid cell cultures. Results.--Comparative genomic hybridization analysis was successfully performed on 856 samples from spontaneously aborted specimens and term placentas. Failure of analysis occurred in 1.6% of samples and was due to an insufficient amount of tissue for DNA extraction. Comparative genomic hybridization identified aneuploidy in 53% of spontaneous abortion samples and 3.1% of term placentas. Conclusions.--Comparative genomic hybridization analysis is a useful clinical tool for detection of aneuploidy in placental and fetal tissues. It provides a genome-wide screen while eliminating tissue culture failures, culture artifacts, and maternal cell contamination. We present practical guidelines for interpreting CGH profiles derived from human reproductive specimens. (Arch Pathol Lab Med. 2001;125:81-84), In the practice of reproductive medicine, chromosomal aneuploidy has long been recognized as a significant cause of abnormal prenatal and postnatal development. Traditionally, cytogenetic analysis of cultured tissues from abnormal [...]

Published
2001

39. Colaboradores

Author

Eisenstat, David D., Wigle, Jeffrey T., Chudley, Albert E., Narvey, Michael, Ahing, Steve, Antoniazzi, Franco, Barringer, Dean, Danzinger, e Marnie, Becker, Volker, Been, J.V., Benacerraf, Beryl, Bhatnagar, Kunwar, Bolender, David, Branco Ferreira, Dr. Mario João, Cleghorn, Blaine M., Golarz De Bourne, Dr. M.N., Dean, Heather, Del Bigio, Marc, Fanos, Vassilios, Fernandes Rodrigues, João Carlos, Gaillard, Frank, Geddes, Gary, Grayson, Barry H., Vendittelli, Bruno L., Harman, Christopher R., Hay, Jean, Henderson, Blair, Hill, Lyndon M., Hinrichsen, Klaus V., Margaret Jackson, Dr. Jon e Sra., Jain, Evelyn, Jane, John A., Sr., Jordan, Robert, Juretschke, Linda J., Kalousek, Dagmar K., Klatt, E.C., Lee, Wesley, Levine, Deborah, (Ted) Lyons, E.A., Morris, Margaret, Morrison, Stuart C., Mulliken, John B., Oakes, W. Jerry, Parkinson, Dwight, Patel, Maulik S., Phillips, Dra. Susan, Ramachandra, Srinivasa, Ray, M., Reed, Martin H., Reid, Gregory J., Michael, Rice, Michele, Robben, Dr. S.G., Sahni, Prem S., Schuurman, Dr. M.J., Schwartz, P., Michelmann, H.M., Siebert, Joseph R., Smith, Bradley R., Smyser, Gerald S., Soucy, Pierre, Suzuki, Dr. Y., Shane Tubbs, R., Uthman, Edward O., Wiseman, Nathan E., and Zenzes, M.T.

Published
2016
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40. Fetal pathology

Author

Kalousek, Dagmar K.

Subjects
Book Review
Published
1997

41. Colaboradores

Author

Eisenstat, David D., Wigle, Jeffrey T., Chudley, Albert E., Narvey, Michael, Ahing, Steve, Antoniazzi, Franco, Fanos, Vassilios, Becker, Volker, Been, J., Shuurman, M., Robben, S., Bolender, David, Brugger, Peter C., Cheng, Jack C.Y., Cleghorn, Blaine M., Dean, Heather, Del Bigio, Marc, Fernandes Rodrigues, João Carlos, Gaillard, Frank, Geddes, Gary, Grayson, Barry H., Vendittelli, Bruno L., Harman, Christopher R., Hay, Jean, Health Sciences Centre, Hill, Lyndon M., Hinrichsen, Klaus V., Jain, Evelyn, Jane, Sr. John A., Kalousek, Dagmar K., Koenig, James, Lee, Wesley, Levine, Deborah, Leyder, Mina, Lyons, E.A.(Ted), Patel, Maulik S., Reed, Martin H., Reid, Gregory J., Michael, Rice, Michele, Sahni, Prem S., Smyser, Gerald S., Soucy, Pierre, Stanislavsky, Alexandra, Tubbs, R. Shane, Oakes, W. Jerry, Uthman, Edward O., Whitby, Elspeth H., and Wiseman, Nathan E.

Published
2015
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50. Molecular Cytogenetics in Reproductive Pathology.

Author

Walker, John M., Fan, Yao-Shan, Bruyére, Héléne, Rajcan-Separovic, Evica, and Kalousek, Dagmar K.

Abstract

Conventional cytogenetic analysis has contributed for the last 35 yr to establishing the etiology of spontaneous abortions (SAs), representing an important diagnostic aid for reproductive pathologists, geneticists, and physicians. There is however a problem in obtaining a cytogenetic result from 10-30% of abortion specimens owing to culture failure. In addition, growth of maternally-derived cells in culture can result in a false negative result. Nowadays, new molecular cytogenetic tools are available to get cytogenetic information in almost all cases of SA submitted to the Cytogenetics laboratory. [ABSTRACT FROM AUTHOR]

Published
2003
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