Search

Your search keyword '"Kalloger, Steve E"' showing total 401 results
Start Over Author "Kalloger, Steve E"
401 results on '"Kalloger, Steve E"'

3. Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma

Author

Topham, James T., Tsang, Erica S., Karasinska, Joanna M., Metcalfe, Andrew, Ali, Hassan, Kalloger, Steve E., Csizmok, Veronika, Williamson, Laura M., Titmuss, Emma, Nielsen, Karina, Negri, Gian Luca, Spencer Miko, Sandra E., Jang, Gun Ho, Denroche, Robert E., Wong, Hui-li, O’Kane, Grainne M., Moore, Richard A., Mungall, Andrew J., Loree, Jonathan M., Notta, Faiyaz, Wilson, Julie M., Bathe, Oliver F., Tang, Patricia A., Goodwin, Rachel, Morin, Gregg B., Knox, Jennifer J., Gallinger, Steven, Laskin, Janessa, Marra, Marco A., Jones, Steven J. M., Schaeffer, David F., and Renouf, Daniel J.

Published
2022
Full Text
View/download PDF

4. Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

Author

McDonald, Paul C., Chafe, Shawn C., Brown, Wells S., Saberi, Saeed, Swayampakula, Mridula, Venkateswaran, Geetha, Nemirovsky, Oksana, Gillespie, Jordan A., Karasinska, Joanna M., Kalloger, Steve E., Supuran, Claudiu T., Schaeffer, David F., Bashashati, Ali, Shah, Sohrab P., Topham, James T., Yapp, Donald T., Li, Jinyang, Renouf, Daniel J., Stanger, Ben Z., and Dedhar, Shoukat

Published
2019
Full Text
View/download PDF

5. ATG4B and ATG4A loss result in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells

Author

Sathiyaseelan, Paalini, primary, Chittaranjan, Suganthi, additional, Kalloger, Steve E., additional, Chan, Jennifer, additional, Go, Nancy E., additional, Jardon, Mario A., additional, Ho, Cally J., additional, Hui, Theodore, additional, Xu, Jing, additional, Chow, Christine, additional, Gao, Dongxia, additional, Johnson, Fraser D., additional, Lockwood, William W., additional, Morin, Gregg B., additional, Renouf, Daniel J., additional, Schaeffer, David F., additional, and Gorski, Sharon M., additional

Published
2023
Full Text
View/download PDF

11. Data from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Topham, James T., primary, Titmuss, Emma, primary, Pleasance, Erin D., primary, Williamson, Laura M., primary, Karasinska, Joanna M., primary, Culibrk, Luka, primary, Lee, Michael K.C., primary, Mendis, Shehara, primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Kalloger, Steve E., primary, Wong, Hui-Li, primary, Moore, Richard A., primary, Mungall, Andrew J., primary, O'Kane, Grainne M., primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Loree, Jonathan M., primary, Mager, Dixie L., primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Schaeffer, David F., primary, and Renouf, Daniel J., primary

Published
2023
Full Text
View/download PDF

12. Supplementary table 2 from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Topham, James T., primary, Titmuss, Emma, primary, Pleasance, Erin D., primary, Williamson, Laura M., primary, Karasinska, Joanna M., primary, Culibrk, Luka, primary, Lee, Michael K.C., primary, Mendis, Shehara, primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Kalloger, Steve E., primary, Wong, Hui-Li, primary, Moore, Richard A., primary, Mungall, Andrew J., primary, O'Kane, Grainne M., primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Loree, Jonathan M., primary, Mager, Dixie L., primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Schaeffer, David F., primary, and Renouf, Daniel J., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Table 5 from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Topham, James T., primary, Titmuss, Emma, primary, Pleasance, Erin D., primary, Williamson, Laura M., primary, Karasinska, Joanna M., primary, Culibrk, Luka, primary, Lee, Michael K.C., primary, Mendis, Shehara, primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Kalloger, Steve E., primary, Wong, Hui-Li, primary, Moore, Richard A., primary, Mungall, Andrew J., primary, O'Kane, Grainne M., primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Loree, Jonathan M., primary, Mager, Dixie L., primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Schaeffer, David F., primary, and Renouf, Daniel J., primary

Published
2023
Full Text
View/download PDF

14. Supplementary table 1 and figures 1-4 from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Topham, James T., primary, Titmuss, Emma, primary, Pleasance, Erin D., primary, Williamson, Laura M., primary, Karasinska, Joanna M., primary, Culibrk, Luka, primary, Lee, Michael K.C., primary, Mendis, Shehara, primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Kalloger, Steve E., primary, Wong, Hui-Li, primary, Moore, Richard A., primary, Mungall, Andrew J., primary, O'Kane, Grainne M., primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Loree, Jonathan M., primary, Mager, Dixie L., primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Schaeffer, David F., primary, and Renouf, Daniel J., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Table 4 from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Topham, James T., primary, Titmuss, Emma, primary, Pleasance, Erin D., primary, Williamson, Laura M., primary, Karasinska, Joanna M., primary, Culibrk, Luka, primary, Lee, Michael K.C., primary, Mendis, Shehara, primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Kalloger, Steve E., primary, Wong, Hui-Li, primary, Moore, Richard A., primary, Mungall, Andrew J., primary, O'Kane, Grainne M., primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Loree, Jonathan M., primary, Mager, Dixie L., primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Schaeffer, David F., primary, and Renouf, Daniel J., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Table 3 from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Topham, James T., primary, Titmuss, Emma, primary, Pleasance, Erin D., primary, Williamson, Laura M., primary, Karasinska, Joanna M., primary, Culibrk, Luka, primary, Lee, Michael K.C., primary, Mendis, Shehara, primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Kalloger, Steve E., primary, Wong, Hui-Li, primary, Moore, Richard A., primary, Mungall, Andrew J., primary, O'Kane, Grainne M., primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Loree, Jonathan M., primary, Mager, Dixie L., primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Schaeffer, David F., primary, and Renouf, Daniel J., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Table S5 from IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

Author

Anglesio, Michael S., primary, George, Joshy, primary, Kulbe, Hagen, primary, Friedlander, Michael, primary, Rischin, Danny, primary, Lemech, Charlotte, primary, Power, Jeremy, primary, Coward, Jermaine, primary, Cowin, Prue A., primary, House, Colin M., primary, Chakravarty, Probir, primary, Gorringe, Kylie L., primary, Campbell, Ian G., primary, Okamoto, Aikou, primary, Birrer, Michael J., primary, Huntsman, David G., primary, de Fazio, Anna, primary, Kalloger, Steve E., primary, Balkwill, Frances, primary, Gilks, C. Blake, primary, and Bowtell, David D., primary

Published
2023
Full Text
View/download PDF

18. Figure S6 from Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer

Author

Karasinska, Joanna M., primary, Topham, James T., primary, Kalloger, Steve E., primary, Jang, Gun Ho, primary, Denroche, Robert E., primary, Culibrk, Luka, primary, Williamson, Laura M., primary, Wong, Hui-Li, primary, Lee, Michael K.C., primary, O'Kane, Grainne M., primary, Moore, Richard A., primary, Mungall, Andrew J., primary, Moore, Malcolm J., primary, Warren, Cassia, primary, Metcalfe, Andrew, primary, Notta, Faiyaz, primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Renouf, Daniel J., primary, and Schaeffer, David F., primary

Published
2023
Full Text
View/download PDF

19. Supplementary Materials from Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics

Author

Topham, James T., primary, Karasinska, Joanna M., primary, Lee, Michael K.C., primary, Csizmok, Veronika, primary, Williamson, Laura M., primary, Jang, Gun Ho, primary, Denroche, Robert E., primary, Tsang, Erica S., primary, Kalloger, Steve E., primary, Wong, Hui-li, primary, O'Kane, Grainne M., primary, Moore, Richard A., primary, Mungall, Andrew J., primary, Notta, Faiyaz, primary, Loree, Jonathan M., primary, Wilson, Julie M., primary, Bathe, Oliver, primary, Tang, Patricia A., primary, Goodwin, Rachel, primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Renouf, Daniel J., primary, and Schaeffer, David F., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Tables S1-S4 from Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer

Author

Guan, Yinghui, primary, Kuo, Wen-Lin, primary, Stilwell, Jackie L., primary, Takano, Hirokuni, primary, Lapuk, Anna V., primary, Fridlyand, Jane, primary, Mao, Jian-Hua, primary, Yu, Mamie, primary, Miller, Melinda A., primary, Santos, Jennifer L., primary, Kalloger, Steve E., primary, Carlson, Joseph W., primary, Ginzinger, David G., primary, Celniker, Susan E., primary, Mills, Gordon B., primary, Huntsman, David G., primary, and Gray, Joe W., primary

Published
2023
Full Text
View/download PDF

21. Supplementary Figures S1-S5 from IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

Author

Anglesio, Michael S., primary, George, Joshy, primary, Kulbe, Hagen, primary, Friedlander, Michael, primary, Rischin, Danny, primary, Lemech, Charlotte, primary, Power, Jeremy, primary, Coward, Jermaine, primary, Cowin, Prue A., primary, House, Colin M., primary, Chakravarty, Probir, primary, Gorringe, Kylie L., primary, Campbell, Ian G., primary, Okamoto, Aikou, primary, Birrer, Michael J., primary, Huntsman, David G., primary, de Fazio, Anna, primary, Kalloger, Steve E., primary, Balkwill, Frances, primary, Gilks, C. Blake, primary, and Bowtell, David D., primary

Published
2023
Full Text
View/download PDF

22. Supplementary Data from Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?

Author

Tsang, Erica S., primary, Topham, James T., primary, Karasinska, Joanna M., primary, Lee, Michael K.C., primary, Williamson, Laura M., primary, Mendis, Shehara, primary, Denroche, Robert E., primary, Jang, Gun Ho, primary, Kalloger, Steve E., primary, Moore, Richard A., primary, Mungall, Andrew J., primary, Bathe, Oliver F., primary, Tang, Patricia A., primary, Notta, Faiyaz, primary, Wilson, Julie M., primary, Laskin, Janessa, primary, O'Kane, Grainne M., primary, Knox, Jennifer J., primary, Goodwin, Rachel A., primary, Loree, Jonathan M., primary, Jones, Steven J.M., primary, Marra, Marco A., primary, Gallinger, Steven, primary, Schaeffer, David F., primary, and Renouf, Daniel J., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Tables 1-9 from Biomarker-Based Ovarian Carcinoma Typing: A Histologic Investigation in the Ovarian Tumor Tissue Analysis Consortium

Author

Köbel, Martin, primary, Kalloger, Steve E., primary, Lee, Sandra, primary, Duggan, Máire A., primary, Kelemen, Linda E., primary, Prentice, Leah, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Visscher, Daniel W., primary, Keeney, Gary L., primary, Vierkant, Robert A., primary, Cunningham, Julie M., primary, Chow, Christine, primary, Ness, Roberta B., primary, Moysich, Kirsten, primary, Edwards, Robert, primary, Modugno, Francesmary, primary, Bunker, Clareann, primary, Wozniak, Eva L., primary, Benjamin, Elizabeth, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Gilks, C. Blake, primary, Huntsman, David G., primary, Ramus, Susan J., primary, and Goode, Ellen L., primary

Published
2023
Full Text
View/download PDF

24. Supplementary Methods from IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

Author

Anglesio, Michael S., primary, George, Joshy, primary, Kulbe, Hagen, primary, Friedlander, Michael, primary, Rischin, Danny, primary, Lemech, Charlotte, primary, Power, Jeremy, primary, Coward, Jermaine, primary, Cowin, Prue A., primary, House, Colin M., primary, Chakravarty, Probir, primary, Gorringe, Kylie L., primary, Campbell, Ian G., primary, Okamoto, Aikou, primary, Birrer, Michael J., primary, Huntsman, David G., primary, de Fazio, Anna, primary, Kalloger, Steve E., primary, Balkwill, Frances, primary, Gilks, C. Blake, primary, and Bowtell, David D., primary

Published
2023
Full Text
View/download PDF

25. Supplementary Figure Legend from Biomarker-Based Ovarian Carcinoma Typing: A Histologic Investigation in the Ovarian Tumor Tissue Analysis Consortium

Author

Köbel, Martin, primary, Kalloger, Steve E., primary, Lee, Sandra, primary, Duggan, Máire A., primary, Kelemen, Linda E., primary, Prentice, Leah, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Visscher, Daniel W., primary, Keeney, Gary L., primary, Vierkant, Robert A., primary, Cunningham, Julie M., primary, Chow, Christine, primary, Ness, Roberta B., primary, Moysich, Kirsten, primary, Edwards, Robert, primary, Modugno, Francesmary, primary, Bunker, Clareann, primary, Wozniak, Eva L., primary, Benjamin, Elizabeth, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Gilks, C. Blake, primary, Huntsman, David G., primary, Ramus, Susan J., primary, and Goode, Ellen L., primary

Published
2023
Full Text
View/download PDF

26. Supplementary Figure 1 from Biomarker-Based Ovarian Carcinoma Typing: A Histologic Investigation in the Ovarian Tumor Tissue Analysis Consortium

Author

Köbel, Martin, primary, Kalloger, Steve E., primary, Lee, Sandra, primary, Duggan, Máire A., primary, Kelemen, Linda E., primary, Prentice, Leah, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Visscher, Daniel W., primary, Keeney, Gary L., primary, Vierkant, Robert A., primary, Cunningham, Julie M., primary, Chow, Christine, primary, Ness, Roberta B., primary, Moysich, Kirsten, primary, Edwards, Robert, primary, Modugno, Francesmary, primary, Bunker, Clareann, primary, Wozniak, Eva L., primary, Benjamin, Elizabeth, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Gilks, C. Blake, primary, Huntsman, David G., primary, Ramus, Susan J., primary, and Goode, Ellen L., primary

Published
2023
Full Text
View/download PDF

27. Data from Biomarker-Based Ovarian Carcinoma Typing: A Histologic Investigation in the Ovarian Tumor Tissue Analysis Consortium

Author

Köbel, Martin, primary, Kalloger, Steve E., primary, Lee, Sandra, primary, Duggan, Máire A., primary, Kelemen, Linda E., primary, Prentice, Leah, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Visscher, Daniel W., primary, Keeney, Gary L., primary, Vierkant, Robert A., primary, Cunningham, Julie M., primary, Chow, Christine, primary, Ness, Roberta B., primary, Moysich, Kirsten, primary, Edwards, Robert, primary, Modugno, Francesmary, primary, Bunker, Clareann, primary, Wozniak, Eva L., primary, Benjamin, Elizabeth, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Gilks, C. Blake, primary, Huntsman, David G., primary, Ramus, Susan J., primary, and Goode, Ellen L., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figures S1-S2 from Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer

Author

Guan, Yinghui, primary, Kuo, Wen-Lin, primary, Stilwell, Jackie L., primary, Takano, Hirokuni, primary, Lapuk, Anna V., primary, Fridlyand, Jane, primary, Mao, Jian-Hua, primary, Yu, Mamie, primary, Miller, Melinda A., primary, Santos, Jennifer L., primary, Kalloger, Steve E., primary, Carlson, Joseph W., primary, Ginzinger, David G., primary, Celniker, Susan E., primary, Mills, Gordon B., primary, Huntsman, David G., primary, and Gray, Joe W., primary

Published
2023
Full Text
View/download PDF

29. Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells.

Author

Sathiyaseelan, Paalini, Chittaranjan, Suganthi, Kalloger, Steve E., Chan, Jennifer, Go, Nancy E., Jardon, Mario A., Ho, Cally J., Hui Hui, Theodore, Jing Xu, Chow, Christine, Dongxia Gao, Johnson, Fraser D., Lockwood, William W., Morin, Gregg B., Renouf, Daniel J., Schaeffer, David F., and Gorski, Sharon M.

Subjects
PANCREATIC duct, CELL cycle, PHASE transitions, ADENOCARCINOMA, GENE expression
Abstract

Pancreatic ductal adenocarcinoma (PDAC) exhibits elevated levels of autophagy, which promote tumor progression and treatment resistance. ATG4B is an autophagy-related cysteine protease under consideration as a potential therapeutic target, but it is largely unexplored in PDAC. Here, we investigated the clinical and functional relevance of ATG4B expression in PDAC. Using two PDAC patient cohorts, we found that low ATG4B mRNA or protein expression is associated with worse patient survival outcomes, poorly differentiated PDAC tumors and a lack of survival benefit from adjuvant chemotherapy. In PDAC cell lines, ATG4B knockout reduced proliferation, abolished processing of LC3B (also known as MAP1LC3B), and reduced GABARAP and GABARAPL1 levels, but increased ATG4A levels. ATG4B and ATG4A double knockout lines displayed a further reduction in proliferation, characterized by delays in G1-S phase transition and mitosis. Pro-LC3B accumulated aberrantly at the centrosome with a concomitant increase in centrosomal proteins PCM1 and CEP131, which was rescued by exogenous ATG4B. The two-stage cell cycle defects following ATG4B and ATG4A loss have important therapeutic implications for PDAC. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

31. Abstract B053: Targeting SMURF1 with low-dose proteasome inhibitors in pancreatic cancer organoids

Author

Metcalfe, Andrew, primary, Karasinska, Joanna M., additional, Topham, James T., additional, Kalloger, Steve E., additional, Ali, Hassan, additional, Ashforth, Dawn, additional, Marra, Marco A., additional, Laskin, Janessa, additional, Tang, Patricia A., additional, Goodwin, Rachel, additional, Bathe, Oliver F., additional, Renouf, Daniel J., additional, and Schaeffer, David F., additional

Published
2022
Full Text
View/download PDF

38. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

Author

Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, BeGora, Michael, Lohse, Ines, Ngai, Nicholas, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi B, Crawford, Howard C, Arrowsmith, Cheryl, Kalloger, Steve E, Renouf, Daniel J, Connor, Ashton A, Cleary, Sean, Schaeffer, David F, Roehrl, Michael, Tsao, Ming-Sound, Gallinger, Steven, Keller, Gordon, and Muthuswamy, Senthil K

Subjects
Mortality -- Analysis, Precision medicine -- Usage, Cancer screening -- Usage, Pancreatic cancer -- Care and treatment -- Diagnosis, Stem cells -- Research, Biological sciences, Health
Abstract

There are few in vitro models of exocrine pancreas development and primary human pancreatic adenocarcinoma (PDAC). We establish three-dimensional culture conditions to induce the differentiation of human pluripotent stem cells into exocrine progenitor organoids that form ductal and acinar structures in culture and in vivo. Expression of mutant KRAS or TP53 in progenitor organoids induces mutation-specific phenotypes in culture and in vivo. Expression of TP53[sup.R175H] induces cytosolic SOX9 localization. In patient tumors bearing TP53 mutations, SOX9 was cytoplasmic and associated with mortality. We also define culture conditions for clonal generation of tumor organoids from freshly resected PDAC. Tumor organoids maintain the differentiation status, histoarchitecture and phenotypic heterogeneity of the primary tumor and retain patient-specific physiological changes, including hypoxia, oxygen consumption, epigenetic marks and differences in sensitivity to inhibition of the histone methyltransferase EZH2. Thus, pancreatic progenitor organoids and tumor organoids can be used to model PDAC and for drug screening to identify precision therapy strategies., Author(s): Ling Huang [1]; Audrey Holtzinger [1, 2]; Ishaan Jagan [1]; Michael BeGora [1]; Ines Lohse [1]; Nicholas Ngai [1]; Cristina Nostro [1, 2]; Rennian Wang [3, 4]; Lakshmi B [...]

Published
2015
Full Text
View/download PDF

42. Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms

Author

Yang, Kevin C., primary, Kalloger, Steve E., additional, Aird, John J., additional, Lee, Michael K.C., additional, Rushton, Christopher, additional, Mungall, Karen L., additional, Mungall, Andrew J., additional, Gao, Dongxia, additional, Chow, Christine, additional, Xu, Jing, additional, Karasinska, Joanna M., additional, Colborne, Shane, additional, Jones, Steven J.M., additional, Schrader, Jörg, additional, Morin, Ryan D., additional, Loree, Jonathan M., additional, Marra, Marco A., additional, Renouf, Daniel J., additional, Morin, Gregg B., additional, Schaeffer, David F., additional, and Gorski, Sharon M., additional

Published
2021
Full Text
View/download PDF

46. ARID1A mutations in endometriosis-associated ovarian carcinomas

Author

Wiegand, Kimberly C., Shah, Sohrab P., Al-Agha, Osama M., Yongjun Zhao, Tse, Kane, Zeng, Thomas, Senz, Janine, McConechy, Melissa K., Anglesio, Michael S., Kalloger, Steve E., Yang, Winnie, Heravi-Moussavi, Alireza, Guiliany, Ryan, Chow, Christine, Fee, John, Zayed, Abdalnasser, Prentice, Leah, Melnyk, Nataliya, Turashvili, Gulisa, Delaney, Allan D., Madore, Jason, Yip, Stephen, McPherson, Andrew W., Ha, Gavin, Bell, Lynda, Fereday, Sian, Tam, Angela, Galletta, Laura, Tonin, Patricia N., Provencher, Diane, Miller, Dianne, Jones, Steven J.M., Moore, Richard A., Morin, Gregg B., Oloumi, Arusha, Boyd, Niki, Aparicio, Samuel A., le_Ming Shih, Mes_Masson, Anne-Marie, Bowtell, David B., Hirst, Martin, Gilks, Blake, Marra, Marco A., and Huntsman, David

Subjects
Ovarian cancer -- Genetic aspects, Ovarian cancer -- Care and treatment, Gene mutations -- Research, Endometriosis -- Genetic aspects, Endometriosis -- Causes of, Tumor suppressor genes -- Research
Abstract

The study attempts to evaluate the data derived from the RNA sequencing of 18 ovarian carcinomas to identify variants in ARID1A mutations. The results indicate that ARIDIA mutations are present in ovarian carcinomas and that it is indicative of an early event in the transformation of endometriosis into cancer.

Published
2010

47. Mutation of FOXL2 in granulosa-cell tumors of the ovary

Author

Shah, Sohrab P., Kobel, Martin, Senz, Janine, Morin, Ryan D., Clarke, Blaise A., Wiegand, Kimberly C., Leung, Gillian, Zayed, Abdalnasser, Mehl, Erika, Kalloger, Steve E., Sun, Mark, Giuliany, Ryan, Yorida, Erika, Jones, Steven, Varhol, Richard, Swenerton, Kenneth D., Miller, Dianne, Clement, Philip B., Crane, Colleen, Madore, Jason, Provencher, Diane, Leung, Peter, DeFazio, Anna, Khattra, Jaswinder, Turashvili, Gulisa, Zhao, Yongjun, Zeng, Thomas, Glover, J.N. Mark, Vanderhyden, Barbara, Zhao, Chengquan, Parkinson, Christine A., Jimenez-Linan, Mercedes, Bowtell, David D.L., Aparicio, Samuel A., Boyd, Niki, Hirst, Martin, Gilks, Blake, Marra, Marco, Mes-Masson, Anne-Marie, and Brenton, James D.

Subjects
Granulosa cell tumor -- Causes of, Granulosa cell tumor -- Research, Granulosa cell tumor -- Genetic aspects
Abstract

The study aims to investigate four adult-type granulosa-cell tumors (GCTs) of the ovary and the role of FOXL2 mutation in the pathogenesis of GCTs. The results indicate that mutant FOXL2 is responsible for adult-type GCTs of the ovary.

Published
2009

48. Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing

Author

Dixon, Katherine, primary, Brew, Tom, additional, Farnell, David, additional, Godwin, Tanis D, additional, Cheung, Simon, additional, Chow, Christine, additional, Ta, Monica, additional, Ho, Germain, additional, Bui, Minh, additional, Douglas, J Maxwell, additional, Campbell, Kieran R, additional, El‐Naggar, Amal, additional, Kaurah, Pardeep, additional, Kalloger, Steve E, additional, Lim, Howard J, additional, Schaeffer, David F, additional, Cochrane, Dawn, additional, Guilford, Parry, additional, and Huntsman, David G, additional

Published
2021
Full Text
View/download PDF

49. Ovarian carcinoma subtypes are different diseases: implications for biomarker studies

Author

Kobel, Martin, Kalloger, Steve E., Boyd, Niki, McKinney, Steven, Mehl, Erika, Palmera, Chana, Leung, Samuel, Bowen, Nathan J., Ionescu, Diana N., Rajput, Ashish, Prentice, Leah M., Miller, Dianne, Santos, Jennifer, Swenerton, Kenneth, Gilks, C. Blake, and Huntsman, David

Subjects
Cancer -- Adjuvant treatment, Tumor markers -- Usage -- Health aspects -- Care and treatment -- Diagnosis -- Research, Ovarian cancer -- Diagnosis -- Care and treatment -- Research, Biological sciences
Abstract

Background Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural histories, most ovarian carcinoma biomarker studies and current treatment protocols for women with this disease are not subtype specific. With the emergence of high-throughput molecular techniques, distinct pathogenetic pathways have been identified in these subtypes. We examined variation in biomarker expression rates between subtypes, and how this influences correlations between biomarker expression and stage at diagnosis or prognosis. Methods and Findings In this retrospective study we assessed the protein expression of 21 candidate tissue-based biomarkers (CA125, CRABP-II, EpCam, ER, F-Spondin, HE4, IGF2, K-Cadherin, Ki-67, KISS1, Matriptase, Mesothelin, MIF, MMP7, p21, p53, PAX8, PR, SLPI, TROP2, WT1) in a populationbased cohort of 500 ovarian carcinomas that was collected over the period from 1984 to 2000. The expression of 20 of the 21 biomarkers differs significantly between subtypes, but does not vary across stage within each subtype. Survival analyses show that nine of the 21 biomarkers are prognostic indicators in the entire cohort but when analyzed by subtype only three remain prognostic indicators in the high-grade serous and none in the clear cell subtype. For example, tumor proliferation, as assessed by Ki-67 staining, varies markedly between different subtypes and is an unfavourable prognostic marker in the entire cohort (risk ratio [RR] 1.7, 95% confidence interval [CI] 1.2%-2.4%) but is not of prognostic significance within any subtype. Prognostic associations can even show an inverse correlation within the entire cohort, when compared to a specific subtype. For example, WT1 is more frequently expressed in high-grade serous carcinomas, an aggressive subtype, and is an unfavourable prognostic marker within the entire cohort of ovarian carcinomas (RR 1.7, 95% CI 1.2%-2.3%), but is a favourable prognostic marker within the high-grade serous subtype (RR 0.5, 95% CI 0.3%-0.8%). Conclusions The association of biomarker expression with survival varies substantially between subtypes, and can easily be overlooked in whole cohort analyses. To avoid this effect, each subtype within a cohort should be analyzed discretely. Ovarian carcinoma subtypes are different diseases, and these differences should be reflected in clinical research study design and ultimately in the management of ovarian carcinoma. The Editors' Summary of this article follows the references., Introduction Ovarian carcinoma is a heterogeneous disease. On the basis of histopathological examination, pathologists classify ovarian carcinoma into serous, clear cell, endometrioid, and mucinous subtypes. Each of theses subtypes is [...]

Published
2008

50. Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics

Author

Topham, James T., primary, Karasinska, Joanna M., additional, Lee, Michael K.C., additional, Csizmok, Veronika, additional, Williamson, Laura M., additional, Jang, Gun Ho, additional, Denroche, Robert E., additional, Tsang, Erica S., additional, Kalloger, Steve E., additional, Wong, Hui-li, additional, O'Kane, Grainne M., additional, Moore, Richard A., additional, Mungall, Andrew J., additional, Notta, Faiyaz, additional, Loree, Jonathan M., additional, Wilson, Julie M., additional, Bathe, Oliver, additional, Tang, Patricia A., additional, Goodwin, Rachel, additional, Knox, Jennifer J., additional, Gallinger, Steven, additional, Laskin, Janessa, additional, Marra, Marco A., additional, Jones, Steven J.M., additional, Renouf, Daniel J., additional, and Schaeffer, David F., additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results