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While the general prognostic factors for colorectal carcinoma have been widely researched, the compound relationships between tumor characteristics and development of colorectal liver metastases have not been clearly understood. The aim of this study was to determine which histopathological characteristics of colorectal cancer may be associated with subsequent development of colorectal liver metastases. We performed retrospective and prospective study which included 80 patients operated for colorectal carcinoma on the First Surgical Clinic of Clinical Center of Serbia in Belgrade. Retrospective group consisted of 40 patients operated between 1992. and 1996. while prospective group included 40 patients treated between 1997. and 2001. We analyzed the size of the tumor, depth of invasion through the intestinal wall, extramural spread of the tumor, infiltration of blood vessels and lymphatics, lymph node involvement, tumor maturation and growth, as well circumferential intestinal involvement. Statistical analysis performed showed highly significant (p<0,01) correlation between the tumor size, degree of maturation of the tumor, extramural spread and involvement of the venules with later development of colorectal liver metastases in both groups.

In the period ranging from 1985. to 1994. a total number of 86 patients have been treated for toxic adenoma (TA). Hyperthyroidism was more often present in males (70.83% versus 51.61%) and in enlarged adenomas (more then 2 cm in diameter). Pathohistologic type of adenoma influenced degenerative changes. Three carcinoma have been observed, two papillary and one follicular. Surgical treatment is the method of choice. Complications are rare (3.49%) and mild.

Hydatide disease of the adrenal gland is extremely rare, even in disseminated disease. Isolated cyst of the gland is even more rare. Only 9 of such cases seem to have been described so far. We present a 49 year old woman in whom a hydatide cyst of the right gland was found during the investigation for the dull pain in the area. She was successfully operated. Hydatide etiology was confirmed at operation and by histology. She had an uneventful recovery. The preoperative pain disappeared postoperatively.

Adenomyomatosis of the gall bladder is a rare benign disease in which hypertrophic mucosa makes deep sinuses into hypetrophic muscular layer making, the so called Rokitansky-Aschoff's sinuses. It appears as a localised, segmental or diffuse form of the disease. Localised adnomyomatosis leads to the formation of "tumorous" lesions. Two patients, a 44-year old man and a 67-year old woman in whom "tumorous" lesions of the gall bladder were diagnosed preoperatively, are presented. Both patients were operated on. Cholecystectomy was carried out. "Tumorous" changes were, in fact, a localised form of adenomyomatosis, what was histologically confirmed.

Mesenteric panniculitis is a very rare disease usually involving the mesentery of the small bowel, less frequently the sigmoid colon or other intraabdominal fat tissue. The disease is benign with a favorable prognosis. Diagnosis is, as a rule, established at operation or autopsy and histology. A 58 year old male with this disease is presented. The paticut hod mild abdominal pain and a palpable mass. A tumor of the mesentery was suspected on CT scan. The exact diagnosis was established at operation and confirmed at histology.

Authors described operative method of subfascial discision of perforators by the use special phlebotomy for it. Intrahospital (517 legs) and long term (76 patients) was analyzed. The operation with subfascial discision of perforators has shown the best results compared with the ligature and resection these veins.