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1. Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans

Author

Akinyemi, Rufus O., Tiwari, Hemant K., Srinivasasainagendra, Vinodh, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Mamaeva, Olga A., Halloran, Brian A., Akinyemi, Joshua, Lackland, Daniel, Obiabo, Olugbo Y., Sunmonu, Taofik, Chukwuonye, Innocent I., Arulogun, Oyedunni, Jenkins, Carolyn, Adeoye, Abiodun, Agunloye, Atinuke, Ogah, Okechukwu S., Ogbole, Godwin, Fakunle, Adekunle, Uvere, Ezinne, Coker, Motunrayo M., Okekunle, Akinkunmi, Asowata, Osahon, Diala, Samuel, Ogunronbi, Mayowa, Adeleye, Osi, Laryea, Ruth, Tagge, Raelle, Adeniyi, Sunday, Adusei, Nathaniel, Oguike, Wisdom, Olowoyo, Paul, Adebajo, Olayinka, Olalere, Abimbola, Oladele, Olayinka, Yaria, Joseph, Fawale, Bimbo, Ibinaye, Philip, Oyinloye, Olalekan, Mensah, Yaw, Oladimeji, Omotola, Akpalu, Josephine, Calys-Tagoe, Benedict, Dambatta, Hamisu A., Ogunniyi, Adesola, Kalaria, Rajesh, Arnett, Donna, Rotimi, Charles, Ovbiagele, Bruce, and Owolabi, Mayowa O.

Published
2024
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2. Neuropathology of microbleeds in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Author

Magaki, Shino, Chen, Zesheng, Severance, Alyscia, Williams, Christopher, Diaz, Ramiro, Fang, Chuo, Khanlou, Negar, Yong, William, Paganini-Hill, Annlia, Kalaria, Rajesh, Vinters, Harry, and Fisher, Mark

Subjects
Aging, CADASIL, Cerebral microbleed, Hemosiderin, Immunohistochemistry, Small vessel disease, Humans, CADASIL, Hemosiderin, Cerebral Infarction, Leukoencephalopathies, Magnetic Resonance Imaging, Cerebral Hemorrhage, Iron
Abstract

Cerebral microbleeds (CMBs) detected on magnetic resonance imaging are common in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The neuropathologic correlates of CMBs are unclear. In this study, we characterized findings relevant to CMBs in autopsy brain tissue of 8 patients with genetically confirmed CADASIL and 10 controls within the age range of the CADASIL patients by assessing the distribution and extent of hemosiderin/iron deposits including perivascular hemosiderin leakage (PVH), capillary hemosiderin deposits, and parenchymal iron deposits (PID) in the frontal cortex and white matter, basal ganglia and cerebellum. We also characterized infarcts, vessel wall thickening, and severity of vascular smooth muscle cell degeneration. CADASIL subjects had a significant increase in hemosiderin/iron deposits compared with controls. This increase was principally seen with PID. Hemosiderin/iron deposits were seen in the majority of CADASIL subjects in all brain areas. PVH was most pronounced in the frontal white matter and basal ganglia around small to medium sized arterioles, with no predilection for the vicinity of vessels with severe vascular changes or infarcts. CADASIL subjects have increased brain hemosiderin/iron deposits but these do not occur in a periarteriolar distribution. Pathogenesis of these lesions remains uncertain.

Published
2023

3. Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Montrreal, Laura, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Franco-Macías, Emilio, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Frank-García, Ana, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-Madrona, Sebastián, García-González, Pablo, Alarcón-Martín, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Pérez-Cordón, Alba, Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Martín Montes, Angel, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Abdelnour, Carla, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., and Ruiz, Agustín

Published
2023
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4. Dementia in Africa: Current evidence, knowledge gaps, and future directions

Author

Akinyemi, Rufus O, Yaria, Joseph, Ojagbemi, Akin, Guerchet, Maëlenn, Okubadejo, Njideka, Njamnshi, Alfred K, Sarfo, Fred S, Akpalu, Albert, Ogbole, Godwin, Ayantayo, Temitayo, Adokonou, Thierry, Paddick, Stella‐Maria, Ndetei, David, Bosche, Judith, Ayele, Biniyam, Damas, Andrea, Coker, Motunrayo, Mbakile‐Mahlanza, Lingani, Ranchod, Kirti, Bobrow, Kirsten, Anazodo, Udunna, Damasceno, Albertino, Seshadri, Sudha, Pericak‐Vance, Margaret, Lawlor, Brian, Miller, Bruce L, Owolabi, Mayowa, Baiyewu, Olusegun, Walker, Richard, Gureje, Oye, Kalaria, Rajesh N, Ogunniyi, Adesola, and Consortium, the African Dementia

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Alzheimer's Disease, Genetics, Aging, Brain Disorders, Dementia, Neurodegenerative, Neurological, Good Health and Well Being, Aged, Alzheimer Disease, Apolipoprotein E4, Dementia, Vascular, Genome-Wide Association Study, Genotype, Humans, Africa, Alzheimer's disease, consortium, dementia, epidemiology, genetics, neuropathology, biomarkers, precision medicine, vascular dementia, African Dementia Consortium, neuropathology. biomarkers, Geriatrics, Clinical sciences, Biological psychology
Abstract

In tandem with the ever-increasing aging population in low and middle-income countries, the burden of dementia is rising on the African continent. Dementia prevalence varies from 2.3% to 20.0% and incidence rates are 13.3 per 1000 person-years with increasing mortality in parts of rapidly transforming Africa. Differences in nutrition, cardiovascular factors, comorbidities, infections, mortality, and detection likely contribute to lower incidence. Alzheimer's disease, vascular dementia, and human immunodeficiency virus/acquired immunodeficiency syndrome-associated neurocognitive disorders are the most common dementia subtypes. Comprehensive longitudinal studies with robust methodology and regional coverage would provide more reliable information. The apolipoprotein E (APOE) ε4 allele is most studied but has shown differential effects within African ancestry compared to Caucasian. More candidate gene and genome-wide association studies are needed to relate to dementia phenotypes. Validated culture-sensitive cognitive tools not influenced by education and language differences are critically needed for implementation across multidisciplinary groupings such as the proposed African Dementia Consortium.

Published
2022

6. Brain arteriolosclerosis

Author

Blevins, Brittney L, Vinters, Harry V, Love, Seth, Wilcock, Donna M, Grinberg, Lea T, Schneider, Julie A, Kalaria, Rajesh N, Katsumata, Yuriko, Gold, Brian T, Wang, Danny JJ, Ma, Samantha J, Shade, Lincoln MP, Fardo, David W, Hartz, Anika MS, Jicha, Gregory A, Nelson, Karin B, Magaki, Shino D, Schmitt, Frederick A, Teylan, Merilee A, Ighodaro, Eseosa T, Phe, Panhavuth, Abner, Erin L, Cykowski, Matthew D, Van Eldik, Linda J, and Nelson, Peter T

Subjects
Biomedical and Clinical Sciences, Neurosciences, Aging, Brain Disorders, Acquired Cognitive Impairment, Alzheimer's Disease Related Dementias (ADRD), Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Neurodegenerative, Vascular Cognitive Impairment/Dementia, 2.1 Biological and endogenous factors, Aetiology, Neurological, Mental health, Aged, Aged, 80 and over, Animals, Arterioles, Brain, Cerebral Amyloid Angiopathy, Cognition Disorders, Humans, Intracranial Arteriosclerosis, Neuroimaging, SVD, Arteriosclerosis, cAVU, Senescence, Neuropathology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC. Recent research indicates other and more complex risk factors and pathogenetic mechanisms. Here, we describe aspects of the unique architecture of brain arterioles, histomorphologic features of B-ASC, relevant neuroimaging findings, epidemiology and association with aging, established genetic risk factors, and the co-occurrence of B-ASC with other neuropathologic conditions such as Alzheimer's disease and limbic-predominant age-related TDP-43 encephalopathy (LATE). There may also be complex physiologic interactions between metabolic syndrome (e.g., hypertension and inflammation) and brain arteriolar pathology. Although there is no universally applied diagnostic methodology, several classification schemes and neuroimaging techniques are used to diagnose and categorize cerebral small vessel disease pathologies that include B-ASC, microinfarcts, microbleeds, lacunar infarcts, and cerebral amyloid angiopathy (CAA). In clinical-pathologic studies that factored in comorbid diseases, B-ASC was independently associated with impairments of global cognition, episodic memory, working memory, and perceptual speed, and has been linked to autonomic dysfunction and motor symptoms including parkinsonism. We conclude by discussing critical knowledge gaps related to B-ASC and suggest that there are probably subcategories of B-ASC that differ in pathogenesis. Observed in over 80% of autopsied individuals beyond 80 years of age, B-ASC is a complex and under-studied contributor to neurologic disability.

Published
2021

7. Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Author

Sweeney, Melanie D, Montagne, Axel, Sagare, Abhay P, Nation, Daniel A, Schneider, Lon S, Chui, Helena C, Harrington, Michael G, Pa, Judy, Law, Meng, Wang, Danny JJ, Jacobs, Russell E, Doubal, Fergus N, Ramirez, Joel, Black, Sandra E, Nedergaard, Maiken, Benveniste, Helene, Dichgans, Martin, Iadecola, Costantino, Love, Seth, Bath, Philip M, Markus, Hugh S, Salman, Rustam A, Allan, Stuart M, Quinn, Terence J, Kalaria, Rajesh N, Werring, David J, Carare, Roxana O, Touyz, Rhian M, Williams, Steve CR, Moskowitz, Michael A, Katusic, Zvonimir S, Lutz, Sarah E, Lazarov, Orly, Minshall, Richard D, Rehman, Jalees, Davis, Thomas P, Wellington, Cheryl L, González, Hector M, Yuan, Chun, Lockhart, Samuel N, Hughes, Timothy M, Chen, Christopher LH, Sachdev, Perminder, O'Brien, John T, Skoog, Ingmar, Pantoni, Leonardo, Gustafson, Deborah R, Biessels, Geert Jan, Wallin, Anders, Smith, Eric E, Mok, Vincent, Wong, Adrian, Passmore, Peter, Barkof, Frederick, Muller, Majon, Breteler, Monique MB, Román, Gustavo C, Hamel, Edith, Seshadri, Sudha, Gottesman, Rebecca F, van Buchem, Mark A, Arvanitakis, Zoe, Schneider, Julie A, Drewes, Lester R, Hachinski, Vladimir, Finch, Caleb E, Toga, Arthur W, Wardlaw, Joanna M, and Zlokovic, Berislav V

Subjects
Blood-Brain Barrier, Brain, Humans, Alzheimer Disease, Vascular Diseases, Cerebrovascular Circulation, United States, National Institute on Aging (U.S.), Amyloid beta-Peptides, White Matter, Biomarkers, Alzheimer's disease, Blood-brain barrier, Cerebral blood flow, MRI, Vascular, National Institute on Aging, Neurosciences, Clinical Sciences, Geriatrics
Abstract

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD pathophysiology, including changes in blood-brain barrier integrity and cerebral blood flow. Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize. We suggest that these vascular biomarkers should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts.

Published
2019

8. Lack of Association of Vascular Risk Factors with HIV-Associated Neurocognitive Disorders in cART-Treated Adults Aged ≥ 50 Years in Tanzania

Author

Flack, Katherine A., primary, Rainey, Emma S., additional, Urasa, Sarah J., additional, Koipapi, Sengua, additional, Kalaria, Rajesh N., additional, Howlett, William P., additional, Mukaetova-Ladinska, Elizabeta B., additional, Dekker, Marieke C. J., additional, Gray, William K., additional, Walker, Richard W., additional, Dotchin, Catherine L., additional, Mtwaile, Himidi, additional, Lewis, Thomas C. D., additional, Stone, Lydia G., additional, McNally, Richard J. Q., additional, Makupa, Philip C., additional, and Paddick, Stella-Maria, additional

Published
2024
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11. Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Montrreal, Laura, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Franco-Macías, Emilio, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Frank-García, Ana, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-Madrona, Sebastián, García-González, Pablo, Alarcón-Martín, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Pérez-Cordón, Alba, Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Martín Montes, Angel, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Abdelnour, Carla, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., and Ruiz, Agustín

Published
2021
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13. Vascular dysfunction—The disregarded partner of Alzheimer's disease

Author

Sweeney, Melanie D., Montagne, Axel, Sagare, Abhay P., Nation, Daniel A., Schneider, Lon S., Chui, Helena C., Harrington, Michael G., Pa, Judy, Law, Meng, Wang, Danny J.J., Jacobs, Russell E., Doubal, Fergus N., Ramirez, Joel, Black, Sandra E., Nedergaard, Maiken, Benveniste, Helene, Dichgans, Martin, Iadecola, Costantino, Love, Seth, Bath, Philip M., Markus, Hugh S., Salman, Rustam A., Allan, Stuart M., Quinn, Terence J., Kalaria, Rajesh N., Werring, David J., Carare, Roxana O., Touyz, Rhian M., Williams, Steve C.R., Moskowitz, Michael A., Katusic, Zvonimir S., Lutz, Sarah E., Lazarov, Orly, Minshall, Richard D., Rehman, Jalees, Davis, Thomas P., Wellington, Cheryl L., González, Hector M., Yuan, Chun, Lockhart, Samuel N., Hughes, Timothy M., Chen, Christopher L.H., Sachdev, Perminder, O'Brien, John T., Skoog, Ingmar, Pantoni, Leonardo, Gustafson, Deborah R., Biessels, Geert Jan, Wallin, Anders, Smith, Eric E., Mok, Vincent, Wong, Adrian, Passmore, Peter, Barkof, Frederick, Muller, Majon, Breteler, Monique M.B., Román, Gustavo C., Hamel, Edith, Seshadri, Sudha, Gottesman, Rebecca F., van Buchem, Mark A., Arvanitakis, Zoe, Schneider, Julie A., Drewes, Lester R., Hachinski, Vladimir, Finch, Caleb E., Toga, Arthur W., Wardlaw, Joanna M., and Zlokovic, Berislav V.

Published
2019
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15. Research participants’ perception of ethical issues in stroke genomics and neurobiobanking research in Africa

Author

Jegede, Ayodele, primary, Balogun, Olubukola, additional, Olorunsogbon, Olorunyomi Felix, additional, Nichols, Michelle, additional, Akinyemi, Joshua, additional, Jenkins, Carolyn, additional, Ogunronbi, Mayowa, additional, Singh, Arti, additional, Obiako, Reginald, additional, Wahab, Kolawole, additional, Bello, Abiodun, additional, Akpalu, Albert, additional, Sarfo, Fred S., additional, Owolabi, Lukman F., additional, Ojebuyi, Babatunde, additional, Adigun, Muyiwa, additional, Olujobi, Dorcas, additional, Musbahu, Rabiu, additional, Titiloye, Musibau, additional, Afolami, Ibukun, additional, Calys-Tagoe, Benedict, additional, Uvere, Ezinne, additional, Laryea, Ruth, additional, Fakunle, Adekunle, additional, Adeleye, Osi, additional, Adesina, Deborah, additional, Mensah, Nathaniel, additional, Oguike, Wisdom, additional, Coleman, Nathaniel, additional, Adeniyi, Sunday, additional, Omotoso, Lanre, additional, Asibey, Shadrack, additional, Melikam, Lois, additional, Yusuf, Jibril, additional, Gbenga, Abdullateef, additional, Mande, Aliyu, additional, Uthman, Muhammed, additional, Kalaria, Rajesh N., additional, Owolabi, Mayowa, additional, Ovbiagele, Bruce, additional, Arulogun, Oyedunni, additional, and Akinyemi, Rufus O., additional

Published
2023
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16. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study

Author

Taragano, F.E., Kril, J., Cavalieri, M., Jellinger, K.A., Kovacs, G.G., Engelborghs, S., Lafosse, C., Bertolucci, P.H., Brucki, S., Caramelli, P., de Toledo Ferraz Alves, T.C., Bocti, C., Fulop, T., Hogan, D.B., Hsiung, G.R., Kirk, A., Leach, L., Robillard, A., Sahlas, D.J., Guo, Q., Tian, J., Hokkanen, L., Jokinen, H., Benisty, S., Deramecourt, V., Hauw, J., Lenoir, H., Tsatali, M., Tsolaki, M., Sundar, U., Coen, R.F., Korczyn, A.D., Altieri, M., Baldereschi, M., Caltagirone, C., Caravaglios, G., Di Carlo, A., Di Piero, V., Gainotti, G., Galluzzi, S., Logroscino, G., Mecocci, P., Moretti, D.V., Padovani, A., Fukui, T., Ihara, M., Mizuno, T., Kim, S.Y., Akinyemi, R., Baiyewu, O., Ogunniyi, A., Szczudlik, A., Bastos-Leite, A.J., Firmino, H., Massano, J., Verdelho, A., Kruglov, L.S., Ikram, M.K., Kandiah, N., Arana, E., Barroso-Ribal, J., Calatayud, T., Cruz-Jentoft, A.J., López-Pousa, S., Martinez-Lage, P., Mataro, M., Börjesson-Hanson, A., Englund, E., Laukka, E.J., Qiu, C., Viitanen, M., Biessels, G.J., de Leeuw, F.-E., den Heijer, T., Exalto, L.G., Kappelle, L.J., Prins, N.D., Richard, E., Schmand, B., van den Berg, E., van der Flier, W.M., Bilgic, B., Allan, L.M., Archer, J., Attems, J., Bayer, A., Blackburn, D., Brayne, C., Bullock, R., Connelly, P.J., Farrant, A., Fish, M., Harkness, K., Ince, P.G., Langhorne, P., Mann, J., Matthews, F.E., Mayer, P., Pendlebury, S.T., Perneczky, R., Peters, R., Smithard, D., Stephan, B.C., Swartz, J.E., Todd, S., Werring, D.J., Wijayasiri, S.N., Wilcock, G., Zamboni, G., Au, R., Borson, S., Bozoki, A., Browndyke, J.N., Corrada, M.M., Crane, P.K., Diniz, B.S., Etcher, L., Fillit, H., Greenberg, S.M., Grinberg, L.T., Hurt, S.W., Lamar, M., Mielke, M., Ott, B.R., Perry, G., Powers, W.J., Ramos-Estebanez, C., Reed, B., Roberts, R.O., Romero, J.R., Saykin, A.J., Seshadri, S., Silbert, L., Stern, Y., Zarow, C., Skrobot, Olivia A., Black, Sandra E., Chen, Christopher, DeCarli, Charles, Erkinjuntti, Timo, Ford, Gary A., Kalaria, Rajesh N., O'Brien, John, Pantoni, Leonardo, Pasquier, Florence, Roman, Gustavo C., Wallin, Anders, Sachdev, Perminder, Skoog, Ingmar, Ben-Shlomo, Yoav, Passmore, Anthony P., Love, Seth, and Kehoe, Patrick G.

Published
2018
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18. The Vascular Impairment of Cognition Classification Consensus Study

Author

Taragano, F.E., Kril, J., Cavalieri, M., Jellinger, K.A., Kovacs, G.G., Engelborghs, S., Lafosse, C., Bertolucci, P.H., Brucki, S., Caramelli, P., de Toledo Ferraz Alves, T.C., Bocti, C., Fulop, T., Hogan, D.B., Hsiung, G.R., Kirk, A., Leach, L., Robillard, A., Sahlas, D.J., Guo, Q., Tian, J., Hokkanen, L., Jokinen, H., Benisty, S., Deramecourt, V., Hauw, J., Lenoir, H., Tsatali, M., Tsolaki, M., Sundar, U., Coen, R.F., Korczyn, A.D., Altieri, M., Baldereschi, M., Caltagirone, C., Caravaglios, G., Di Carlo, A., DI Piero, V., Gainotti, G., Galluzzi, S., Logroscino, G., Mecocci, P., Moretti, D.V., Padovani, A., Fukui, T., Ihara, M., Mizuno, T., Kim, S.Y., Akinyemi, R., Baiyewu, O., Ogunniyi, A., Szczudlik, A., Bastos-Leite, A.J., Firmino, H., Massano, J., Verdelho, A., Kruglov, L.S., Ikram, M.K., Kandiah, N., Arana, E., Barroso-Ribal, J., Calatayud, T., Cruz-Jentoft, A.J., López-Pousa, S., Martinez-Lage, P., Mataro, M., Börjesson-Hanson, A., Englund, E., Laukka, E.J., Qiu, C., Viitanen, M., Biessels, G.J., de Leeuw, F.-E., den Heijer, T., Exalto, L.G., Kappelle, L.J., Prins, N.D., Richard, E., Schmand, B., van den Berg, E., van der Flier, W.M., Bilgic, B., Allan, L.M., Archer, J., Attems, J., Bayer, A., Blackburn, D., Brayne, C., Bullock, R., Connelly, P.J., Farrant, A., Fish, M., Harkness, K., Ince, P.G., Langhorne, P., Mann, J., Matthews, F.E., Mayer, P., Pendlebury, S.T., Perneczky, R., Peters, R., Smithard, D., Stephan, B.C., Swartz, J.E., Todd, S., Werring, D.J., Wijayasiri, S.N., Wilcock, G., Zamboni, G., Au, R., Borson, S., Bozoki, A., Browndyke, J.N., Corrada, M.M., Crane, P.K., Diniz, B.S., Etcher, L., Fillit, H., Greenberg, S.M., Grinberg, L.T., Hurt, S.W., Lamar, M., Mielke, M., Ott, B.R., Perry, G., Powers, W.J., Ramos-Estebanez, C., Reed, B., Roberts, R.O., Romero, J.R., Saykin, A.J., Seshadri, S., Silbert, L., Stern, Y., Zarow, C., Skrobot, Olivia A., O'Brien, John, Black, Sandra, Chen, Christopher, DeCarli, Charles, Erkinjuntti, Timo, Ford, Gary A., Kalaria, Rajesh N., Pantoni, Leonardo, Pasquier, Florence, Roman, Gustavo C., Wallin, Anders, Sachdev, Perminder, Skoog, Ingmar, Ben-Shlomo, Yoav, Passmore, Anthony P., Love, Seth, and Kehoe, Patrick G.

Published
2017
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21. UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings

Author

McFall, Aisling, Hietamies, Tuuli M, Bernard, Ashton, Aimable, Margaux, Allan, Stuart M, Bath, Philip M, Brezzo, Gaia, Carare, Roxana O, Carswell, Hilary V, Clarkson, Andrew N, Currie, Gillian, Farr, Tracy D, Fowler, Jill H, Good, Mark, Hainsworth, Atticus H, Hall, Catherine, Horsburgh, Karen, Kalaria, Rajesh, Kehoe, Patrick, Lawrence, Catherine, Macleod, Malcolm, McColl, Barry W, McNeilly, Alison, Miller, Alyson A, Miners, Scott, Mok, Vincent, O’Sullivan, Michael, Platt, Bettina, Sena, Emily S, Sharp, Matthew, Strangward, Patrick, Szymkowiak, Stefan, Touyz, Rhian M, Trueman, Rebecca C, White, Claire, McCabe, Chris, Work, Lorraine M, and Quinn, Terence J

Published
2020
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22. Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups

Author

Lo, Jessica W., Crawford, John D., Desmond, David W., Godefroy, Olivier, Jokinen, Hanna, Mahinrad, Simin, Bae, Hee-Joon, Lim, Jae-Sung, Köhler, Sebastian, Douven, Elles, Staals, Julie, Chen, Christopher, Xu, Xin, Chong, Eddie J., Akinyemi, Rufus O., Kalaria, Rajesh N., Ogunniyi, Adesola, Barbay, Mélanie, Roussel, Martine, Lee, Byung-Chul, Srikanth, Velandai K., Moran, Christopher, Kandiah, Nagaendran, Chander, Russell J., Sabayan, Behnam, Jukema, J. Wouter, Melkas, Susanna, Erkinjuntti, Timo, Brodaty, Henry, Bordet, Régis, Bombois, Stéphanie, Hénon, Hilde, Lipnicki, Darren M., Kochan, Nicole A., and Sachdev, Perminder S.

Published
2019
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23. Capacity-Building for Stroke Genomic Research Data Collection: The African Neurobiobank Ethical, Legal, and Social Implications Project Experience

Author

Uvere, Ezinne O., primary, Nichols, Michelle, additional, Ojebuyi, Babatunde R., additional, Isah, Suleiman Yahaya, additional, Calys-Tagoe, Benedict, additional, Jenkins, Carolyn, additional, Obiako, Reginald, additional, Owolabi, Lukman, additional, Akpalu, Albert, additional, Sarfo, Fred Stephen, additional, Ogunronbi, Olumayowa, additional, Adigun, Muyiwa, additional, Fakunle, Gregory Adekunle, additional, Hamzat, Bello, additional, Laryea, Ruth, additional, Uthman, Babatunde, additional, Akinyemi, Joshua O., additional, Adeleye, Osi, additional, Melikam, Lois, additional, Balogun, Olubukola, additional, Sule, Abdullateef, additional, Adeniyi, Sunday, additional, Asibey, Shadrack O., additional, Oguike, Wisdom, additional, Olorunsogbon, Olorunyomi, additional, Singh, Arti, additional, Titiloye, Musibau A., additional, Musbahu, Rabiu, additional, Wahab, Kolawole W., additional, Kalaria, Rajesh N., additional, Jegede, Ayodele S., additional, Owolabi, Mayowa O., additional, Ovbiagele, Bruce, additional, Arulogun, Oyedunni S., additional, and Akinyemi, Rufus O., additional

Published
2023
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24. The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysis

Author

Neurologen, Brain, Circulatory Health, Projectafdeling VCI, Lam, Bonnie Yk, Cai, Yuan, Akinyemi, Rufus, Biessels, Geert Jan, Brink, Hilde van den, Chen, Christopher Lh, Cheung, Chin Wai, Chow, King Ngai, Chung, Henry Kh, Duering, Marco, Fu, Siu Ting, Gustafson, Deborah, Hilal, Saima, Hui, Vincent Mh, Kalaria, Rajesh, Kim, SangYun, Lam, Maggie Lm, de Leeuw, Frank-Erik, Li, Ami Sm, Markus, Hugh S, Marseglia, Anna, Zheng, Huijing, O'brien, John, Pantoni, Leonardo, Sachdev, Perminder S, Smith, Eric Edward, Wardlaw, Joanna, Mok, Vincent Ct, Neurologen, Brain, Circulatory Health, Projectafdeling VCI, Lam, Bonnie Yk, Cai, Yuan, Akinyemi, Rufus, Biessels, Geert Jan, Brink, Hilde van den, Chen, Christopher Lh, Cheung, Chin Wai, Chow, King Ngai, Chung, Henry Kh, Duering, Marco, Fu, Siu Ting, Gustafson, Deborah, Hilal, Saima, Hui, Vincent Mh, Kalaria, Rajesh, Kim, SangYun, Lam, Maggie Lm, de Leeuw, Frank-Erik, Li, Ami Sm, Markus, Hugh S, Marseglia, Anna, Zheng, Huijing, O'brien, John, Pantoni, Leonardo, Sachdev, Perminder S, Smith, Eric Edward, Wardlaw, Joanna, and Mok, Vincent Ct

Published
2023

25. COMMUNICATING ELSI ISSUES IN NEUROBIOBANKING AND STROKE GENOMIC RESEARCH IN AFRICA: PROJECT INTERVENTION TOOLS DEVELOPMENT AND EVALUATION PROCEDURES

Author

Ojebuyi, Babatunde R., Afolami, Ibukun, Adigun, Muyiwa, Singh, Arti, Jenkins, Carolyn, Nichols, Michelle, Wahab, Kolawole, Bello, Abiodun, Sarfo, Fred S., Owolabi, Lukman F., Musbahu, Rabiu, Obiako, Reginald, Akpalu, Albert, Ogunronbi, Mayowa, Olorunsogbon, Olorunyomi, Calys-Tagoe, Benedict, Adesina, Deborah, Coleman, Nathaniel, Sule, Abdullateef G., Mande, Aliyu, Uthman, Muhammed, Titiloye, Musibau, Uvere, Ezinne, Bukola, Odunola, Melikam, Sylvia, Laryea, Ruth, Fakunle, Adekunle, Adeleye, Osi, Mensah, Nathaniel, Yusuf, Jibril, Adeniyi, Sunday, Asibey, Shadrack, Omotoso, Lanre, Melikam, Lois, Olujobi, Dorcas, Oguike, Wisdom, Akinyemi, Joshua, Jegede, Ayodele, Kalaria, Rajesh, Ovbiagele, Bruce, Owolabi, Mayowa, Arulogun, Oyedunni, and Akinyemi, Rufus

Published
2023
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26. The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

Author

Lam, Bonnie Yin Ka, primary, Cai, Yuan, additional, Akinyemi, Rufus, additional, Biessels, Geert Jan, additional, van den Brink, Hilde, additional, Chen, Christopher, additional, Cheung, Chin Wai, additional, Chow, King Ngai, additional, Chung, Henry Kwun Hang, additional, Duering, Marco, additional, Fu, Siu Ting, additional, Gustafson, Deborah, additional, Hilal, Saima, additional, Hui, Vincent Ming Ho, additional, Kalaria, Rajesh, additional, Kim, SangYun, additional, Lam, Maggie Li Man, additional, de Leeuw, Frank Erik, additional, Li, Ami Sin Man, additional, Markus, Hugh Stephen, additional, Marseglia, Anna, additional, Zheng, Huijing, additional, O’Brien, John, additional, Pantoni, Leonardo, additional, Sachdev, Perminder Singh, additional, Smith, Eric E, additional, Wardlaw, Joanna, additional, and Mok, Vincent Chung Tong, additional

Published
2022
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27. Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria

Author

Singh, Arti, primary, Arulogun, Oyedunni, additional, Akinyemi, Joshua, additional, Nichols, Michelle, additional, Calys-Tagoe, Benedict, additional, Ojebuyi, Babatunde, additional, Jenkins, Carolyn, additional, Obiako, Reginald, additional, Akpalu, Albert, additional, Sarfo, Fred, additional, Wahab, Kolawole, additional, Sunday, Adeniyi, additional, Owolabi, Lukman F., additional, Adigun, Muyiwa, additional, Afolami, Ibukun, additional, Olorunsogbon, Olorunyomi, additional, Ogunronbi, Mayowa, additional, Melikam, Ezinne Sylvia, additional, Laryea, Ruth, additional, Asibey, Shadrack, additional, Oguike, Wisdom, additional, Melikam, Lois, additional, Sule, Abdullateef, additional, Titiloye, Musibau A., additional, Yahaya, Isah Suleiman, additional, Bello, Abiodun, additional, Kalaria, Rajesh N., additional, Jegede, Ayodele, additional, Owolabi, Mayowa, additional, Ovbiagele, Bruce, additional, and Akinyemi, Rufus, additional

Published
2022
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28. Human Rights Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa

Author

Adigun, Muyiwa, primary, Ojebuyi, Babatunde Raphael, additional, Akinyemi, Joshua, additional, Wahab, Kolawole, additional, Akpalu, Albert, additional, Sarfo, Fred S., additional, Owolabi, Lukman F., additional, Musbahu, Rabiu, additional, Bello, Abiodun, additional, Obiako, Reginald, additional, Ogunronbi, Mayowa, additional, Singh, Arti, additional, Nichols, Michelle, additional, Jenkins, Carolyn, additional, Jegede, Ayodele, additional, Kalaria, Rajesh, additional, Owolabi, Mayowa, additional, Ovbiagele, Bruce, additional, Arulogun, Oyedunni, additional, and Akinyemi, Rufus, additional

Published
2022
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29. Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease

Author

Littau, Jessica Lisa, primary, Velilla, Lina, additional, Hase, Yoshiki, additional, Villalba‐Moreno, Nelson David, additional, Hagel, Christian, additional, Drexler, Dagmar, additional, Osorio Restrepo, Santiago, additional, Villegas, Andres, additional, Lopera, Francisco, additional, Vargas, Sergio, additional, Glatzel, Markus, additional, Krasemann, Susanne, additional, Quiroz, Yakeel T., additional, Arboleda‐Velasquez, Joseph F., additional, Kalaria, Rajesh, additional, and Sepulveda‐Falla, Diego, additional

Published
2022
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35. Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline

Author

Alfieri, Alessio, Koudelka, Juraj, Li, Mosi, Scheffer, Sanny, Duncombe, Jessica, Caporali, Andrea, Kalaria, Rajesh N., Smith, Colin, Shah, Ajay M., Horsburgh, Karen, Graduate School, ACS - Atherosclerosis & ischemic syndromes, and ACS - Amsterdam Cardiovascular Sciences

Subjects
Inflammation, NADPH oxidase, urogenital system, White Matter, Mice, Inbred C57BL, Mice, Neurology, NADPH Oxidase 2, cardiovascular system, Vascular cognitive impairment, Animals, Carotid Stenosis, Cognitive Dysfunction, Neurology (clinical), Cardiology and Cardiovascular Medicine, cerebral hypoperfusion, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology
Abstract

Chronic microvascular inflammation and oxidative stress are inter-related mechanisms underpinning white matter disease and vascular cognitive impairment (VCI). A proposed mediator is nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2), a major source of reactive oxygen species (ROS) in the brain. To assess the role of Nox2 in VCI, we studied a tractable model with white matter pathology and cognitive impairment induced by bilateral carotid artery stenosis (BCAS). Mice with genetic deletion of Nox2 (Nox2 KO) were compared to wild-type (WT) following BCAS. Sustained BCAS over 12 weeks in WT mice induced Nox2 expression, indices of microvascular inflammation and oxidative damage, along with white matter pathology culminating in a marked cognitive impairment, which were all protected by Nox2 genetic deletion. Neurovascular coupling was impaired in WT mice post-BCAS and restored in Nox2 KO mice. Increased vascular expression of chemoattractant mediators, cell-adhesion molecules and endothelial activation factors in WT mice post-BCAS were ameliorated by Nox2 deficiency. The clinical relevance was confirmed by increased vascular Nox2 and indices of microvascular inflammation in human post-mortem subjects with cerebral vascular disease. Our results support Nox2 activity as a critical determinant of VCI, whose targeting may be of therapeutic benefit in cerebral vascular disease.

Published
2022

36. sj-docx-1-wso-10.1177_17474930221137019 – Supplemental material for The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

Author

Lam, Bonnie Yin Ka, Cai, Yuan, Akinyemi, Rufus, Biessels, Geert Jan, van den Brink, Hilde, Chen, Christopher, Cheung, Chin Wai, Chow, King Ngai, Chung, Henry Kwun Hang, Duering, Marco, Fu, Siu Ting, Gustafson, Deborah, Hilal, Saima, Hui, Vincent Ming Ho, Kalaria, Rajesh, Kim, SangYun, Lam, Maggie Li Man, de Leeuw, Frank Erik, Li, Ami Sin Man, Markus, Hugh Stephen, Marseglia, Anna, Zheng, Huijing, O’Brien, John, Pantoni, Leonardo, Sachdev, Perminder Singh, Smith, Eric E, Wardlaw, Joanna, and Mok, Vincent Chung Tong

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221137019 for The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis by Bonnie Yin Ka Lam, Yuan Cai, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Chen, Chin Wai Cheung, King Ngai Chow, Henry Kwun Hang Chung, Marco Duering, Siu Ting Fu, Deborah Gustafson, Saima Hilal, Vincent Ming Ho Hui, Rajesh Kalaria, SangYun Kim, Maggie Li Man Lam, Frank Erik de Leeuw, Ami Sin Man Li, Hugh Stephen Markus, Anna Marseglia, Huijing Zheng, John O’Brien, Leonardo Pantoni, Perminder Singh Sachdev, Eric E Smith, Joanna Wardlaw and Vincent Chung Tong Mok in International Journal of Stroke

Published
2022
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37. sj-pdf-1-jcb-10.1177_0271678X221077766 - Supplemental material for Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline

Author

Alfieri, Alessio, Koudelka, Juraj, Li, Mosi, Scheffer, Sanny, Duncombe, Jessica, Caporali, Andrea, Kalaria, Rajesh N, Smith, Colin, Shah, Ajay M, and Horsburgh, Karen

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221077766 for Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline by Alessio Alfieri, Juraj Koudelka, Mosi Li, Sanny Scheffer, Jessica Duncombe, Andrea Caporali, Rajesh N Kalaria, Colin Smith, Ajay M Shah and Karen Horsburgh in Journal of Cerebral Blood Flow & Metabolism

Published
2022
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40. Symbolic legislation and the regulation of stroke biobanking and genomics research in Sub-Saharan Africa

Author

Adigun, Muyiwa, primary, Ojebuyi, Babatunde Raphael, additional, Akinyemi, Joshua, additional, Wahab, Kolawole, additional, Akpalu, Albert, additional, Sarfo, Fred S., additional, Owolabi, Lukman F., additional, Musbahu, Rabiu, additional, Bello, Abiodun, additional, Obiako, Reginald, additional, Ogunronbi, Mayowa, additional, Singh, Arti, additional, Nichols, Michelle, additional, Jenkins, Carolyn, additional, Jegede, Ayodele, additional, Kalaria, Rajesh, additional, Owolabi, Mayowa, additional, Ovbiagele, Bruce, additional, Arulogun, Oyedunni, additional, and Akinyemi, Rufus, additional

Published
2022
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41. Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment

Author

Li, Mosi, primary, Kitamura, Akihiro, additional, Beverley, Joshua, additional, Koudelka, Juraj, additional, Duncombe, Jessica, additional, Lennen, Ross, additional, Jansen, Maurits A., additional, Marshall, Ian, additional, Platt, Bettina, additional, Wiegand, Ulrich K., additional, Carare, Roxana O., additional, Kalaria, Rajesh N., additional, Iliff, Jeffrey J., additional, and Horsburgh, Karen, additional

Published
2022
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43. The association of vascular risk factors with cognitive impairment in ART‐treated HIV‐positive adults aged 50 years or older in Northern Tanzania

Author

Flack, Katherine, primary, Rainey, Emma, additional, Urasa, Sarah, additional, Koipapi, Sengua, additional, Kalaria, Rajesh, additional, Mukaetova‐Ladinska, Elizabeta, additional, Howlett, William, additional, Dekker, Marieke, additional, Walker, Richard, additional, McNally, Richard, additional, and Paddick, Stella‐Maria, additional

Published
2021
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44. The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis.

Author

Lam, Bonnie Yin Ka, Cai, Yuan, Akinyemi, Rufus, Biessels, Geert Jan, van den Brink, Hilde, Chen, Christopher, Cheung, Chin Wai, Chow, King Ngai, Chung, Henry Kwun Hang, Duering, Marco, Fu, Siu Ting, Gustafson, Deborah, Hilal, Saima, Hui, Vincent Ming Ho, Kalaria, Rajesh, Kim, SangYun, Lam, Maggie Li Man, de Leeuw, Frank Erik, Li, Ami Sin Man, and Markus, Hugh Stephen

Subjects
CEREBRAL small vessel diseases, MIDDLE-income countries, LACUNAR stroke, MAGNETIC resonance imaging, STROKE, COMMUNITIES
Abstract

Background: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries. Studies investigating the prevalence of cSVD in low- and middle-income countries (LMICs) are expanding but have not been systematically assessed. Aim: This study aims to systematically review the prevalence of cSVD in LMICs. Results: Articles were searched from the Ovid MEDLINE and EMBASE databases from 1 January 2000 to 31 March 2022, without language restrictions. Title/abstract screening, full-text review, and data extraction were performed by two to seven independent reviewers. The prevalence of cSVD and study sample size were extracted by pre-defined world regions and health status. The Risk of Bias for Non-randomized Studies tool was used. The protocol was registered on PROSPERO (CRD42022311133). A meta-analysis of proportion was performed to assess the prevalence of different magnetic resonance imaging markers of cSVD, and a meta-regression was performed to investigate associations between cSVD prevalence and type of study, age, and male: female ratio. Of 2743 studies identified, 42 studies spanning 12 global regions were included in the systematic review. Most of the identified studies were from China (n = 23). The median prevalence of moderate-to-severe white matter hyperintensities (WMHs) was 20.5%, 40.5%, and 58.4% in the community, stroke, and dementia groups, respectively. The median prevalence of lacunes was 0.8% and 33.5% in the community and stroke groups. The median prevalence of cerebral microbleeds (CMBs) was 10.7% and 22.4% in the community and stroke groups. The median prevalence of moderate-to-severe perivascular spaces was 25.0% in the community. Meta-regression analyses showed that the weighted median age (51.4 ± 0.0 years old; range: 36.3–80.2) was a significant predictor of the prevalence of moderate-to-severe WMH and lacunes, while the type of study was a significant predictor of the prevalence of CMB. The heterogeneity of studies was high (>95%). Male participants were overrepresented. Conclusions: This systematic review and meta-analysis provide data on cSVD prevalence in LMICs and demonstrated the high prevalence of the condition. cSVD research in LMICs is being published at an increasing rate, especially between 2010 and 2022. More data are particularly needed from Sub-Saharan Africa and Central Europe, Eastern Europe, and Central Asia. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Erratum to: Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future (Alzheimer's & Dementia, (2020), 16, 11, (1571-1581), 10.1002/alz.12143)

Author

Mok, Vincent C. T., Pendlebury, Sarah, Wong, Adrian, Alladi, Suvarna, Au, Lisa, Bath, Philip M., Biessels, Geert Jan, Chen, Christopher, Cordonnier, Charlotte, Dichgans, Martin, Dominguez, Jacqueline, Gorelick, Philip B., Kim, SangYun, Kwok, Timothy, Greenberg, Steven M., Jia, Jianping, Kalaria, Rajesh, Kivipelto, Miia, Naegandran, Kandiah, Lam, Linda C. W., Lam, Bonnie Yin Ka, Lee, Allen T. C., Markus, Hugh S., O'Brien, John, Pai, Ming-Chyi, Pantoni, Leonardo, Sachdev, Perminder, Senanarong, Vorapun, Skoog, Ingmar, Smith, Eric E., Srikanth, Velandai, Suh, Guk-Hee, Wardlaw, Joanna, Ko, Ho, Black, Sandra E., Scheltens, Philip, Neurology, and Amsterdam Neuroscience - Neurodegeneration

Abstract

In the paper by Mok et al. (“Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.”Alzheimer's Dement. 2020; 16: 1571-1581. https://doi.org/10.1002/alz.12143), an error occurred in the preparation of the paper for publication, requiring the following correction. In the initial publication of this article, Vorapun Senanarong, BSc, MD, was inadvertently omitted from the author group. The corrected author group and affiliations list appear above. We regret the error.

Published
2021

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