Search

Your search keyword '"Kalansuriya, Pabasara"' showing total 18 results
Start Over Author "Kalansuriya, Pabasara"
18 results on '"Kalansuriya, Pabasara"'

4. Gelatine nanoparticles encapsulating three edible plant extracts as potential nanonutraceutical agents against type 2 diabetes mellitus.

Author

Wickramasinghe, Akurange Sujeevi Dammadinna, Attanayake, Anoja Priyadarshani, and Kalansuriya, Pabasara

Subjects
TYPE 2 diabetes, PLANT extracts, ETHANOL, GELATIN, EDIBLE plants, GLUCOSE tolerance tests
Abstract

To optimise, and characterise gelatine nanoparticles (GNPs) encapsulating plant extracts and evaluate the glucose-lowering potential. GNPs encapsulating plant extracts were prepared by desolvation method followed by adsorption. The GNPs were characterised by loading efficiency, loading capacity, particle size, zeta potential, SEM and FTIR. The glucose-lowering activity of GNPs was determined using oral glucose tolerance test in high-fat diet fed streptozotocin-induced Wistar rats. Loading efficiency and capacity, particle mean diameter, and zeta potential of optimised GNPs 72.45 ± 13.03% w/w, 53.05 ± 26.16% w/w, 517 ± 48 nm and (−)23.43 ± 9.96 mV respectively. GNPs encapsulating aqueous extracts of C. grandis, S. auriculata, and ethanol 70% v/v extracts of M. koenigii showed glucose-lowering activity by 17.62%, 11.96% and 13.73% (p < 0.05) compared to the non-encapsulated extracts. FTIR analysis confirmed the encapsulation of phytoconstituents into GNPs. SEM imaging showed spherical GNPs (174 ± 46 nm). GNPs encapsulating plant extracts show promising potential to be developed as nanonutraceuticals against diabetes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Waspergillamide A, a Nitro depsi-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated Aspergillussp. (CMB-W031)

Author

Quezada, Michelle, Shang, Zhuo, Kalansuriya, Pabasara, Salim, Angela A., Lacey, Ernest, and Capon, Robert J.

Abstract

Chemical profiling of extracts from a mud dauber wasp-associated fungus, Aspergillussp. (CMB-W031), revealed a remarkably diverse array of secondary metabolites, with many biosynthetic gene clusters being transcriptionally responsive to specific culture conditions. Chemical fractionation of a jasmine rice cultivation yielded many known fungal metabolites, including the highly cytotoxic (−)-stephacidin B and an unprecedented nonribosomal peptide synthase derived nitro depsi-tetrapeptide diketopiperazine, waspergillamide A (1). All structures were assigned by detailed spectroscopic analysis and, where appropriate, chemical degradation and Marfey’s analysis.

Published
2017
Full Text
View/download PDF

17. Talarazines A–E: Noncytotoxic Iron(III) Chelators from an Australian Mud Dauber Wasp-Associated Fungus, Talaromycessp. (CMB-W045)

Author

Kalansuriya, Pabasara, Quezada, Michelle, Espósito, Breno P., and Capon, Robert J.

Abstract

Chemical analysis of an Australian mud dauber wasp-associated fungus, Talaromycessp. (CMB-W045), yielded five new coprogen siderophores, talarazines A–E (1–5), together with dimerumic acid (6), desferricoprogen (7), and elutherazine B (8). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C3Marfey’s method. We report on the noncytotoxic Fe(III) chelation properties of 1–8and demonstrate that biosynthesis is regulated by available Fe(III) in culture media. We demonstrate a magnetic nanoparticule approach to extracting high-affinity Fe(III) binding metabolites (i.e., 8) from complex extracts.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results