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22 results on '"Kalamian, Miriam"'

1. Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Author

Duraj, Tomás, Kalamian, Miriam, Zuccoli, Giulio, Maroon, Joseph C., D’Agostino, Dominic P., Scheck, Adrienne C., Poff, Angela, Winter, Sebastian F., Hu, Jethro, Klement, Rainer J., Hickson, Alicia, Lee, Derek C., Cooper, Isabella, Kofler, Barbara, Schwartz, Kenneth A., Phillips, Matthew C. L., Champ, Colin E., Zupec-Kania, Beth, Tan-Shalaby, Jocelyn, Serfaty, Fabiano M., Omene, Egiroh, Arismendi-Morillo, Gabriel, Kiebish, Michael, Cheng, Richard, El-Sakka, Ahmed M., Pflueger, Axel, Mathews, Edward H., Worden, Donese, Shi, Hanping, Cincione, Raffaele Ivan, Spinosa, Jean Pierre, Slocum, Abdul Kadir, Iyikesici, Mehmet Salih, Yanagisawa, Atsuo, Pilkington, Geoffrey J., Chaffee, Anthony, Abdel-Hadi, Wafaa, Elsamman, Amr K., Klein, Pavel, Hagihara, Keisuke, Clemens, Zsófia, Yu, George W., Evangeliou, Athanasios E., Nathan, Janak K., Smith, Kris, Fortin, David, Dietrich, Jorg, Mukherjee, Purna, and Seyfried, Thomas N.

Published
2024
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6. Chapter 6 - Cancer

Author

Noakes, Timothy David, Kalamian, Miriam, Seyfried, Thomas N., Mukherjee, Purna, D’Agostino, Dominic P., Arismendi-Morillo, Gabriel, Chinopoulos, Christos, Tettenborn, Martha, and Winters, Nasha

Published
2023
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13. Additional file 2 of Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial

Author

Adeleh Khodabakhshi, Seyfried, Thomas N., Kalamian, Miriam, Beheshti, Maryam, and Davoodi, Sayed Hossein

Abstract

Additional file 2: figure 2. Median (confidence interval) tyroid hormones in baseline and 12-week by two trial arms in breast cancer patients.

Published
2020
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14. Additional file 1 of Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial

Author

Adeleh Khodabakhshi, Seyfried, Thomas N., Kalamian, Miriam, Beheshti, Maryam, and Davoodi, Sayed Hossein

Subjects
technology, industry, and agriculture, lipids (amino acids, peptides, and proteins)
Abstract

Additional file 1: figure 1. Flow diagram of the patient treatment process.

Published
2020
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15. Consideration of ketogenic metabolic therapy as a complementary or alternative approach for managing breast cancer

Author

Seyfried, Thomas N., Mukherjee, Purna, İyikesici, Mehmet S., Slocum, Abdul, Kalamian, Miriam, Spinosa, Jean-Pierre, Chinopoulos, Christos, and İyikesici, Mehmet S.

Subjects
Inflammation, Survival, Non-Toxic, Fermentation, Glycolysis, Glutaminolysis, Metastasis
Abstract

Chinopoulos, Christos/0000-0003-0183-4149 WOS:000525526600001 PubMed: 32219096 Breast cancer remains as a significant cause of morbidity and mortality in women. Ultrastructural and biochemical evidence from breast biopsy tissue and cancer cells shows mitochondrial abnormalities that are incompatible with energy production through oxidative phosphorylation (OxPhos). Consequently, breast cancer, like most cancers, will become more reliant on substrate level phosphorylation (fermentation) than on oxidative phosphorylation (OxPhos) for growth consistent with the mitochondrial metabolic theory of cancer. Glucose and glutamine are the prime fermentable fuels that underlie therapy resistance and drive breast cancer growth through substrate level phosphorylation (SLP) in both the cytoplasm (Warburg effect) and the mitochondria (Q-effect), respectively. Emerging evidence indicates that ketogenicmetabolic therapy (KMT) can reduce glucose availability to tumor cells while simultaneously elevating ketone bodies, a non-fermentable metabolic fuel. It is suggested that KMT would be most effective when used together with glutamine targeting. Information is reviewed for suggesting how KMT could reduce systemic inflammation and target tumor cells without causing damage to normal cells. Implementation of KMT in the clinic could improve progression free and overall survival for patients with breast cancer. Foundation for Metabolic Cancer Therapies; Claudia Peltz Foundation; George Yu Foundation; Kenneth Rainin Foundation; Boston College Research Expense Fund We thank the Foundation for Metabolic Cancer Therapies, CrossFit Inc., the Nelson and Claudia Peltz Foundation, Joseph C. Maroon, the George Yu Foundation, Kenneth Rainin Foundation, and the Boston College Research Expense Fund for their support.

Published
2020

17. Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study.

Author

Khodabakhshi, Adeleh, Akbari, Mohammad Esmaeil, Mirzaei, Hamid Reza, Mehrad-Majd, Hassan, Kalamian, Miriam, and Davoodi, Sayed Hossein

Subjects
BREAST cancer prognosis, ADIPOSE tissues, BIOMARKERS, BLOOD sugar, BODY composition, BREAST tumors, CANCER chemotherapy, COMBINED modality therapy, DIET, FASTING, KETOGENIC diet, KETONES, METASTASIS, PATIENT compliance, STATISTICAL sampling, SURVIVAL, TRIGLYCERIDES, BODY mass index, RANDOMIZED controlled trials, TREATMENT effectiveness
Abstract

The present study was aimed to evaluate the safety, tolerability, and beneficial effects of a ketogenic diet (KD) on body composition and blood parameters and survival in patients with breast cancer. In this randomized, controlled trial, 60 patients with locally advanced or metastatic breast cancer and planned chemotherapy, were randomly assigned to a group receiving KDs (n = 30) or to a control group with standard diet (n = 30) for 3 months. Serum biochemical parameters and body composition were analyzed at baseline, every 3 weeks and end of each arm. Compliance and safety of KD were also checked weekly. Fasting blood sugar (FBS) was significantly decreased in intervention group compared to the baseline (84.5 ± 11.3 vs. 100.4 ± 11.8, P = 0.001). A significant inter-group difference was also observed for FBS level at end of intervention. There was an increasing trend in serum levels of ketone bodies in intervention group (0.007–0.92, P < 0.001). Compared to the control group, BMI, body weight, and fat% were significantly decreased in intervention group in last visit (P < 0.001). No severe adverse side effect was found regarding lipid profile and kidney or liver marker. Overall survival was higher in KD group compared to the control group in neoadjuvant patients (P = 0.04). Our results suggested that chemotherapy combined with KDs can improve the biochemical parameters, body composition, and overall survival with no substantial side effects in patients with breast cancer. [ABSTRACT FROM AUTHOR]

Published
2020
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20. List of contributors

Author

Adams, Joan, Al Lawati, Ali Irshad, Ali, Nadir, Arismendi-Morillo, Gabriel, Baker, Shawn, Ben-Dor, Miki, Berchuk, Miriam, Berger, Amy, Brazeau, Anne-Sophie, Campbell-McBride, Natasha, Cavan, David, Childers, Ann M., Chinopoulos, Christos, Crofts, Catherine, Cucuzzella, Mark, Cywes, Robert, Deakin, Trudi, Diamond, David M., D’Agostino, Dominic P., Edes, Georgia, Fenwick, Julienne, Fettke, Gary, Friedman, Mark I., Fung, Jason, Gonzalez, Elizabeth, Harvey, Cliff, Hoffmann, Michael, Ifland, Joan, Isaacs, Diana, Kajee, Hassina, Kalamian, Miriam, Kaplan, Bob, Katambo, Daniel, Kossoff, Eric H., Kossoff, Meredith M., Lake, Ian, Lenzkes, Brian, McKelvey, Sean, Mohd Ismail, Nafeeza Hj, Mukherjee, Purna, Murdoch, Campbell, Murphy, Tamzyn, Noakes, Timothy David, Ostoich, Connor, O’Hearn, Amber, Pataguana, Nadia, Perlmutter, David, Phillips, Graham, Phillips, Mathew C.L., Rauch, Laurie, Rice, Sarah M., Riley, Karen, Roberts, Caroline, Rossi, Elisa Marie, Rossi, Fabian, Rossi, Joshua, Saenz, Catherine, Seyfried, Thomas N., Smith, James, Stanton, Angela A., Stephanovic, Mateja, Tettenborn, Martha, Unwin, David, Unwin, Jen, Webster, Christopher, Wellington, Neville, Westman, Eric C., Winters, Nasha, Wolver, Susan, Yancy, William S., Jr., and Zinn, Caryn

Published
2023
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