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Your search keyword '"Kalajian, Andrea D."' showing total 3 results
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3 results on '"Kalajian, Andrea D."'

1. Specular Microscopy Ancillary Study Methods for Donor Endothelial Cell Density Determination of Cornea Donor Study Images

Author

Benetz, Beth Ann, Gal, Robin L., Ruedy, Katrina J., Rice, Carmella, W, Roy, Beck, Kalajian, Andrea D., and Lass, Jonathan H.

Subjects
Quality Control, medicine.medical_specialty, Pathology, genetic structures, Image quality, Cell Count, Eye Banks, Article, Cellular and Molecular Neuroscience, Ophthalmology, Cornea, Microscopy, medicine, Humans, Observer Variation, Chemistry, Endothelium, Corneal, Reproducibility of Results, Eye bank, Ancillary Study, Sensory Systems, Tissue Donors, Endothelial cell density, medicine.anatomical_structure, SPECULAR MICROSCOPY, Corneal endothelial cell density
Abstract

To describe reliable methods for determining central corneal endothelial cell density (ECD) in a multicenter eye bank study.The Specular Microscopy Reading Center utilized a dual-grading procedure and adjudication process to classify image quality and determine ECD for a subset of donor endothelial images obtained in the Specular Microscopy Ancillary Study, which is part of the Cornea Donor Study. Two certified readers classified images as analyzable (excellent, good, fair) or unanalyzable and determined the ECD using a variable frame technique. An adjudicator also evaluated the images if quality classifications by the two readers differed by one grade, if any reader found the image unanalyzable, and/or if the ECD determination between the two readers wasor= 5%.Image quality categorization by the two readers was identical for 441 (64%) of 688 donor images. The ECD differed by5% for 442 (69%) of the 645 analyzable images. The ECD determined by the adjudicator was5% different than the ECD determined by at least one reader for 193 (95%) of the 203 remaining images.The dual-grading and adjudication procedures produce reliable, reproducible assessments of image quality and ECD. The importance of two independent readings is evident in that image quality ratings differed between the two readers by one grade in 36% of all images and ECD counts differed byor=5% for 31% of analyzable images.

Published
2006

3. Clinical profile and early surgical complications in the Cornea Donor Study.

Author

Mannis MJ, Holland EJ, Beck RW, Belin MW, Goldberg MA, Gal RL, Kalajian AD, Kenyon KR, Kollman C, Ruedy KJ, Smith P, Sugar J, and Stark WJ

Subjects
Adult, Aged, Aged, 80 and over, Cornea pathology, Double-Blind Method, Female, Follow-Up Studies, Fuchs' Endothelial Dystrophy surgery, Glaucoma pathology, Glaucoma physiopathology, Humans, Intraocular Pressure, Male, Middle Aged, Postoperative Complications, Prognosis, Prospective Studies, Surgical Wound Dehiscence pathology, Time Factors, Glaucoma etiology, Keratoplasty, Penetrating adverse effects, Surgical Wound Dehiscence etiology, Tissue Donors
Abstract

Purpose: The Cornea Donor Study was designed to investigate the safety and efficacy of older donor corneal tissue compared with younger donor tissue in recipient eyes at moderate risk to the graft from progressive endothelial failure. Baseline patient data, including indications for transplant, intraoperative complication rates, and early postoperative complication rates are described herein., Methods: This study was a multicenter prospective, double-masked, controlled clinical trial., Results: Fuchs dystrophy was the most common indication for corneal transplantation (61%). Intraoperative complications occurred in 33 (3%) patients. A persistent epithelial defect was the most commonly reported postoperative complication, occurring in 92 patients (8%)., Conclusion: Intraoperative and postoperative complication rates were low. There was no apparent association between donor or recipient age and either intraoperative or early postoperative complication rates.

Published
2006
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