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Background: Urological injury in obstetrics and gynaecology are not uncommon because there is a close anatomical association between reproductive and urological system. The objective of this study was to find out the incidence and types of urological injuries in obstetric and gynaecological procedures, clinical presentation and various management option in a tertiary care hospital.Methods: The study was a retrospective analysis of all obstetric and gynecological surgeries over a period of 6 years from January 2014 to December 2019. Cases with the documented urological injuries during these procedures were analyzed further.Results: Total 8595 patients had undergone different obstetrics and gynecology procedures, out of which 5429 were obstetrics and 3166 were gynecology surgeries. Out of 3166 of gynecology procedures, there were 16 cases (0.5%) of bladder injuries and one case (0.03%) of ureteric injury. Out of 5429 cases of obstetric procedures there were 11 (0.2%) cases of bladder injury and one case (0.01%) of ureteric injury.Conclusions: The incidence urological injuries during obstetrics and gynecological procedures are rare but the morbidity associated these are significant. Therefor surgeons should be more cautious and high degree of suspicion can help in early diagnosis and avoid the sequel.

An elevated-temperature polyol-based colloidal-chemistry approach allows for the development of size-tunable (50 and 86 nm) assemblies of maghemite iso-oriented nanocrystals, with enhanced magnetization. (1)H-nuclear magnetic resonance (NMR) relaxometric experiments show that the ferrimagnetic cluster-like colloidal entities exhibit a remarkable enhancement (4-5 times) in transverse relaxivity when compared to that of the superparamagnetic contrast agent Endorem®, over an extended frequency range (1-60 MHz). The marked increase in the transverse relaxivity r2 at a clinical magnetic field strength (∼1.41 T), which is 405.1 and 508.3 mM(-1) s(-1) for small and large assemblies, respectively, makes it possible to relate the observed response to the raised intra-aggregate magnetic material volume fraction. Furthermore, cell tests with a murine fibroblast culture medium confirmed cell viability in the presence of the clusters. We discuss the NMR dispersion profiles on the basis of relaxivity models to highlight the magneto-structural characteristics of the materials for improved T2-weighted magnetic resonance images.

Among the various hyperthermia therapies, Magnetic Fluid Hyperthermia (MFH) using superparamagnetic iron oxide SPIOs has gained interest due to its ability to potentially target and provide a localized heating of the cancerous tissue. In MFH, SPIOs injected into the specific tumor site or functionalized to target the cancerous tissue are heated up by application of an alternating magnetic field. However, injected SPIOs may diffuse to the nearby healthy tissue or may not target the cancerous tissue with 100% efficiency, which in turn cause unwanted heating of the healthy tissue. A recently proposed focused hyperthermia technique spatially limits the heating by utilizing a field free region together with the alternating field [1]. This setup is almost identical to that of a Magnetic Particle Imaging (MPI) scanner: the focused hyperthermia setup employs a strong static magnetic field gradient to saturate all SPIOs outside of a small field free region. Upon applying a time varying excitation field, only the nanoparticles at this field free region react and heat up. Given that these concepts are essentially the same as the field free point (FFP) and drive field used in MPI [2-4], focused hyperthermia and MPI can be performed simultaneously on the same setup.

We have synthesized a new macromolecular architecture, (PAMAM)-CD8 , which consists of eight β-cyclodextrin units (β-CD) attached to a generation 1 poly(amidoamine) (PAMAM) dendrimer through a disulfide bond, which can be cleaved under reducing conditions. This system shows a pronounced hosting capability towards Gd(III) chelates functionalized with hydrophobic groups, thus leading to well-defined supramolecular adducts. (1)H NMR relaxometric investigations were carried out to follow the formation of adducts with three Gd(III) chelates based on the ligand architectures of 6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid (AAZTA) or 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) suitably functionalized with benzyl or adamantyl (Ad) pendant groups. In particular, the ditopic complex composed of two AAZTA chelating units connected to a central aromatic ring that bears an adamantyl group showed a strong affinity (ca. 10(6) M(-1)) for the CD units of the dendrimer, which is two orders of magnitude higher than toward human serum albumin (HSA). Remarkable relaxivity enhancements (i.e., up to 71% at 1 T and 25 °C) were observed upon the formation of the macromolecular host-guest adducts due to a decrease in the molecular tumbling rate and fast water-exchange. Reduction experiments and competition studies between the paramagnetic dendrimer and HSA were carried out by relaxometric techniques. The results show that the metal complexes are not displaced by the protein, thus suggesting that this novel macromolecular probe is potentially suitable for applications in vivo.

We present the first comparative investigation of the Nuclear Magnetic Resonance (NMR) relaxivity of a series of nanosized cyano-bridged coordination networks stabilized in aqueous solution. These Ln(3+)/[Fe(CN)(6)](3-) (Ln = Gd, Tb, Y) and M2+/[Fe(CN)(6)](3-) (M = Ni, Cu, Fe) nanoparticles with sizes ranging from 1.4 to 5.5 nm are stabilized by polyethylene glycols (MW = 400 or 1000), polyethylene glycol fiinctionalized with amine groups (MW = 1500), or by N-acetyl-D-glucosamine. The evaluation of NMR relaxivity allowed estimation of the Magnetic Resonance Imaging (MRI) contrast efficiency of our systems. The results demonstrate that Gd3+/[Fe(CN)(6)](3-) nanoparticles have r(1p) and r(2p) relaxivities about four times higher than the values observed in the same conditions for the commercial Contrast Agents (CAs) ProHance or Omniscan, regardless of the stabilizing agent used, while nanoparticles of Prussian blue and its analogues M2+/[Fe(CN)(6)](3-) (M = Ni, Cu, Fe) present relatively modest values. The influence of the chemical composition of the nanoparticles, their crystal structure, spin values of lanthanide and transition metal ions, and stabilizing agent on the relaxivity values are investigated and discussed.

Synthesis of functionalized magnetic nanoparticles (NPs) for biomedical applications represents a current challenge. In this paper we present the synthesis and characterization of water-dispersible sugar-coated iron oxide NPs specifically designed as magnetic fluid hyperthermia heat mediators and negative contrast agents for magnetic resonance imaging. In particular, the influence of the inorganic core size was investigated. To this end, iron oxide NPs with average size in the range of 4-35 nm were prepared by thermal decomposition of molecular precursors and then coated with organic ligands bearing a phosphonate group on one side and rhamnose, mannose, or ribose moieties on the other side. In this way a strong anchorage of the organic ligand on the inorganic surface was simply realized by ligand exchange, due to covalent bonding between the Fe(3+) atom and the phosphonate group. These synthesized nanoobjects can be fully dispersed in water forming colloids that are stable over very long periods. Mannose, ribose, and rhamnose were chosen to test the versatility of the method and also because these carbohydrates, in particular rhamnose, which is a substrate of skin lectin, confer targeting properties to the nanosystems. The magnetic, hyperthermal, and relaxometric properties of all the synthesized samples were investigated. Iron oxide NPs of ca. 16-18 inn were found to represent an efficient bifunctional targeting system for theranostic applications, as they have very good transverse relaxivity (three times larger than the best currently available commercial products) and large heat release upon application of radio frequency (RF) electromagnetic radiation with amplitude and frequency close to the human tolerance limit. The results have been rationalized on the basis of the magnetic properties of the investigated samples.

A new approach to the synthesis of multifunctional nanoparticles was developed by using covalent anchoring of cyano-bridged coordination polymer Ni2+/[Fe(CN)6]3− to the surface of two-photon dye-doped mesoporous silica nanoparticles. The obtained hybrid nanoparticles were studied by infrared (IR) spectroscopy, nitrogen adsorption (BET), X-ray diffraction, transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), luminescence, and magnetic analysis. The synthesis leads to homogeneously dispersed uni-shaped nanoparticles of around 100 nm in length that are coated with cyano-bridged metallic coordination polymer nanoparticles. These hybrid nanoparticles combine effective two-photon excited fluorescence, porosity, high transverse nuclear relaxivity values (i.e. the magnetic resonance imaging efficiency) and superparamagnetic properties.

The 1H and 17O relaxometric behaviour in aqueous solution of GdF3 nanoparticles (