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8. Fabrication of Artificial Nerve Conduits Used in a Long Nerve Gap: Current Reviews and Future Studies.

Author

Kakinoki, Ryosuke, Hara, Yukiko, Yoshimoto, Koichi, Kaizawa, Yukitoshi, Hashimoto, Kazuhiko, Tanaka, Hiroki, Kobayashi, Takaya, Ohtani, Kazuhiro, Noguchi, Takashi, Ikeguchi, Ryosuke, Akagi, Masao, and Goto, Koji

Subjects
*NERVOUS system regeneration, *NERVES, *NERVE grafting, *SCARS, *SCHWANN cells, *AUTOTRANSPLANTATION
Abstract

There are many commercially available artificial nerve conduits, used mostly to repair short gaps in sensory nerves. The stages of nerve regeneration in a nerve conduit are fibrin matrix formation between the nerve stumps joined to the conduit, capillary extension and Schwann cell migration from both nerve stumps, and, finally, axon extension from the proximal nerve stump. Artificial nerves connecting transected nerve stumps with a long interstump gap should be biodegradable, soft and pliable; have the ability to maintain an intrachamber fibrin matrix structure that allows capillary invasion of the tubular lumen, inhibition of scar tissue invasion and leakage of intratubular neurochemical factors from the chamber; and be able to accommodate cells that produce neurochemical factors that promote nerve regeneration. Here, we describe current progress in the development of artificial nerve conduits and the future studies needed to create nerve conduits, the nerve regeneration of which is compatible with that of an autologous nerve graft transplanted over a long nerve gap. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Soft Tissue Myoepithelioma of the Shoulder

Author

Hashimoto, Kazuhiko, Nishimura, Shunji, Chikugo, Takaaki, Kakinoki, Ryosuke, and Akagi, Masao

Subjects
shoulder, unplanned resection, soft tissue myoepithelioma
Abstract

Soft tissue myoepitheliomas are often misdiagnosed due to their rarity. Herein, we describe a case of soft tissue myoepithelioma of the shoulder. A 72-year-old woman had a suspected sarcoma on her shoulder and under-went open biopsy. She was referred to our hospital, where the tumor was widely resected and the diagnosis of myoepithelioma was histologically confirmed. No recurrence has been observed in the 3 years since the sur-gery. Careful and prompt planning is necessary for the effective treatment of myoepithelioma.

Published
2020

26. Effect of a Rehabilitation Program After Mesenchymal Stromal Cell Transplantation for Advanced Osteonecrosis of the Femoral Head: A 10-Year Follow-Up Study

Author

90378886, 00437229, 80437201, 50762134, 40294938, Aoyama, Tomoki, Goto, Koji, Ikeguchi, Ryosuke, Nankaku, Manabu, Madoba, Katsuyuki, Nagai-Tanima, Momoko, Ito, Akira, Kakinoki, Ryosuke, Nakamura, Takashi, Matsuda, Shuichi, Toguchida, Junya, 90378886, 00437229, 80437201, 50762134, 40294938, Aoyama, Tomoki, Goto, Koji, Ikeguchi, Ryosuke, Nankaku, Manabu, Madoba, Katsuyuki, Nagai-Tanima, Momoko, Ito, Akira, Kakinoki, Ryosuke, Nakamura, Takashi, Matsuda, Shuichi, and Toguchida, Junya

Abstract

Objective: To assess the status of 10 patients with advanced osteonecrosis of the femoral head who underwent mesenchymal stromal cell transplants and a 12-week rehabilitation program 10 years earlier. Design: Retrospective study. Setting: University clinical research laboratory. Participants: Patients (N=10) who had undergone mesenchymal stromal cell transplantation and rehabilitation for a single hip osteonecrosis of the femoral head 10 years prior to the current study were recruited by telephone. The average age was 31.7 years and all participants were men; radiographic stages were 3A in 6 patients and 3B in 4 patients before treatment. Intervention: A 12-week rehabilitation program with follow-up once every 1 to 2 years was performed after mesenchymal stromal cell transplantation. Main Outcome Measures: Radiographic analysis, clinical score, timed Up and Go test, hip function (range of motion, muscle strength), and Short Form-36 scores were assessed before treatment and 1 and 10 years after treatment. Results: Upon imaging, 5 hips were found to be stable (stable group) and 5 had progressed (progressed group); 2 of the latter group required a total hip arthroplasty. The pretreatment radiographic stage of the progressed group was more advanced than that of the stable group. Body mass index was higher in the progressed group than in the stable group. Hip function and clinical score at 1 and 10 years after treatment improved in the hips of 8 patients without total hip arthroplasty. There were no severe adverse events during the rehabilitation. Conclusions: The 12-week rehabilitation program and annual follow-up after mesenchymal stromal cell transplantation for osteonecrosis of the femoral head was associated with pain reduction, maintaining hip muscle strength, widening range of motion, and improving quality of life. The level and timing of weight-bearing and social activity should be planned according to the individual's lifestyle and body composition.

Published
2022

29. The effect of a rehabilitation program after mesenchymal stromal cell transplantation for advanced osteonecrosis of the femoral head: a 10-year follow-up study

Author

Aoyama, Tomoki, primary, Goto, Koji, additional, Ikeguchi, Ryosuke, additional, Nankaku, Manabu, additional, Madoba, Katsuyuki, additional, Nagai-Tanima, Momoko, additional, Ito, Akira, additional, Kakinoki, Ryosuke, additional, Nakamura, Takashi, additional, Matsuda, Shuichi, additional, and Toguchida, Junya, additional

Published
2022
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31. List of Contributors

Author

Abou-Sayed, Hatem, Afrooz, Paul N., Al Deek, Nidal F., Berli, Jens U., Boyd, Kirsty Usher, Brix, Eva, Brown, Stav, Broyles, Justin M., Byrd, Jacqueline N., Cai, Lawrence, Cao, Yilin, Chen, Kellen, Ch'ng, Sydney, Chung, Kevin C., Cladis, Franklyn P., Clark, Audra, Clarke, Alex, Coriddi, Michelle, Diehm, Yannick F., Erdmann-Sager, Jessica, Fahy, Evan, Gallo, Lucas, Gosman, Amanda, Gregorowitsch, Madelijn, Griffin, Michelle F., Gurtner, Geoffrey C., Harms, Karl-Anton, Haug, Valentin, Helliwell, Lydia, Hendren-Santiago, Bryce, Henn, Dominic, Ho, George, Hong, Joon Pio, Hu, Michael S., Hultman, C. Scott, Jazayeri, Leila, Jeffer, Haley M., Jeffers, Lynn, Kane, Gabrielle M., Kauke-Navarro, Martin, King, Timothy W., Klassen, Anne F., Kuehlmann, Britta A., Kuzon, William M., Jr, Levi, Benjamin, Liu, Daniel Z., Liu, Wei, Loder, Shawn, Longaker, Michael T., Peter Lorenz, H., Mackinnon, Susan E., Manahan, Michele A., Mazzola, Isabella C., Mazzola, Riccardo F., Mehrara, Babak J., Momeni, Arash, Morris, Steven F., Morrison, Shane D., Neligan, Peter C., Nelson, Jonas A., Nthumba, Peter, Nuutila, Kristo, Offodile, Anaeze C., Ogawa, Rei, Pannucci, Christopher J., Perrault, David, Pomahac, Bohdan, Power, Hollie A., Prantl, Lukas M., Preminger, B. Aviva, Pripotnev, Stahs, Pusic, Andrea L., Reid, Russell R., Riesel, Johanna N., Rubin, J. Peter, Rumsey, Nichola, Sarhane, Karim A., Schaub, Stephanie K., Seitz, Iris A., Selber, Jesse C., Shayan, Ramin, Sheckter, Clifford C., Sinha, Indranil, Lin Tay, Sherilyn Keng, Taylor, G. Ian, Teven, Chad M., Thoma, Achilleas, Thorne, Charles H., Tsai, Joseph, Varey, Alexander H.R., Varon, David E., Voineskos, Sophocles H., Wei, Fu-Chan, Wilson, Stelios C., Young-Afat, Danny, Zhou, Guangdong, Zielins, Elizabeth R., Almukhtar, Rawaa, A. Alsubaie, Saad, Alter, Gary J., Aly, Al S., Amalfi, Ashley N., Anderson, Eric W., Armijo, Bryan, Aschen, Seth Z., Baker, Daniel C., Barrera, Alfonso, Bellamy, Justin, Bensimon, Richard Hector, Berry, Miles G., Bruner, Terrence W., Cánchica Cano, Andrés F., Capella, Joseph Francis, Centeno, Robert F., Coleman, Sydney R., Constantian, Mark B., Cook, Jonathan, Choi, Hong Lim, Choi, Jong Woo, Coleman, Jayne, Coon, Devin, Davies, Dai M., Salcedo, Jose Abel De la Pena, Del Vecchio, Daniel A., Draelos, Zoe Diana, Di Bernardo, Barry, Eaves, Felmont F., Egro, Francseco M., Elyassnia, Dino, Ellis, Marco, Fabi, Sabrina G., Few, Julius, Jr, Flugstad, Nicholas A., Frame, James D., Frojo, Gianfranco, Gonzalez, Jazmina M., Sosa, David Gonzalez, Grow, Jacob, Gruber, Ronald P., Gusenoff, Jeffrey, Guyuron, Bahman, Hadeed, Josef G., Hunstad, Joseph, Ishii, Clyde, Janis, Jeffrey E., Joseph, Jeremy T., Kahn, David M., Keller, Patrick R., Kenkel, Jeff, Rodriguez, Jocelyn Celeste Ledezma, Levine, Steven, Locke, Michelle, Louis, Matthew, Luthringer, Margaret, Maliha, Samantha G., Mariwalla, Kavita, Marten, Timothy, Matarasso, Alan, Mendelson, Bryan Christopher, Mendieta, Constantino G., Miotto, Gabriele C., Nahai, Foad, Oh, Tae Suk, Paiva, Sabina, Paul, Malcolm, Perdikis, Galen, Pozner, Jason, Ramanadham, Smita R., Richter, Dirk F., Rochlin, Danielle H., Roberts, Thomas L., Rohrich, Rod J., Rubin, Peter J., Rullan, Peter P., Saldanha, Cristianna Bonetto, Saldanha, Osvaldo Ribeiro, Filho, Osvaldo Saldanha, Saltz, Renato, Schoenbrunner, Anna, Schwaiger, Nina, Shulzhenko, Nikita O., Singh, Amitabh, Spinelli, Henry M., Stuzin, James M., Szolomicki, Taisa, Toledo, Luiz, Tonnard, Patrick, Totonchi, Ali, Toy, Jonthan W., Tzur, Rotem, Turer, David, Verpaele, Alexis, Wall, Simeon, Jr, Warren, Richard J., Wong, Chin-Ho, Zhu, Victor, Zide, Barry M., Zins, James E., Adler, Neta, Alabdulkarim, Abdulaziz, Alperovich, Michael, Alvarado, Marta, Antonyshyn, Oleh M., Arnaud, Eric, Aronson, Sofia, Baker, Stephen B., Balkin, Daniel M., Bartlett, Scott P., Bauer, Bruce S., Baylis, Adriane L., Beederman, Maureen, Beh, Han Zhuang, Bentz, Michael, Bergman, Hannah J., Berman, Zoe P., Billig, Allan B., Birgfeld, Craig B., Borschel, Gregory H., Boyd, John Brian, Bradley, James P., Buchanan, Edward P., Buchman, Steven R., Buller, Mitchell, Bykowski, Michael R., Capitán, Luis, Capitán-Cañadas, Fermín, Carlson, Anna R., L. Chang, Brian, Chen, Philip Kuo-Ting, Chen, Yu-Ray, Cheng, Ming-Huei, Chinchilla, Gerson R., Cho, Min-Jeong, Cordeiro, Peter G., Cugno, Sabrina, Daeschler, Simeon C., Dempsey, Robert F., Dibbs, Rami P., Dickie, Sara R., Do, Nicholas, Ettinger, Russell E., Ferry, Andrew M., Figueroa, Alexander L., Figueroa, Alvaro A., Fisher, David M., Flores, Roberto L., Forrest, Christopher R., Gilardino, Mirko S., Glaser, Daniel H., Goldstein, Jesse A., Gosain, Arun K., Gottlieb, Lawrence J., Greene, Arin K., Greives, Matthew R., Haber, Samer E., Halsey, Jordan N., Hammoudeh, Jeffrey, Hanasono, Matthew M., Helms, Jill A., Heuer, Gregory G., Hirsch, David L., Hollier, Larry H., Jr, Hopper, Richard A., Jacobson, Adam S., James, Syril, Jimenez, Christian, Junn, Alexandra, Kapur, Sahil, Kasrai, Leila, Kawamoto, Henry K., Jr, Khonsari, Roman, Kirschner, Richard E., Kondra, Katelyn, Levine, Jamie P., Li, Jingtao, Losee, Joseph E., Mann, Robert Joseph, Manson, Paul N., Massenburg, Benjamin B., Mathijssen, Irene, Menick, Frederick J., Mericli, Alexander F., Monson, Laura A., Morrison, Edwin, Mulliken, John B., Pannuto, Lucia, Paternoster, Giovanna, Persing, John A., Podolsky, Dale J., Pribaz, Julian J., Purnell, Chad A., Rastogi, Pratik, Rodriguez, Eduardo D., Schuster, Lindsay A., Shakir, Afaaf, Shakir, Sameer, Shetye, Pradip R., Simon, Daniel, Smetona, John T., Sommerlad, Brian, Stanton, Eloise, Susarla, Srinivas M., Taub, Peter J., Taylor, Jesse A., Torok, Kathryn S., Tse, Raymond W., Urata, Mark, Vargo, James D., Washington, George, Wolkswinkel, Erik, Yen, Stephen, Yu, Peirong, Zuker, Ronald M., Agarwal, Cori A., Altman, Andrew M., Atia, Andrew Nagy, Attinger, Christopher E., Atves, Jayson N., Brorson, Håkan, Cederna, Paul S., Chang, Brian L., Chang, David W., Chen, Hung-Chi, Chen, Wei F., Dekker, Paige K., Deldar, Romina, Dumanian, Gregory A., Evans, Karen K., Fahradyan, Vahe, Falola, Reuben A., Garza, Rebecca M., Germann, Günter K., Haffner, Zoe K., Andres Hernandez, J., Hollenbeck, Scott Thomas, Hontscharuk, Rayisa, Innocenti, Marco, Johns, Dana N., Khansa, Ibrahim, Kim, Kevin G., Kleiber, Grant M., Kovach, Stephen, Kumar, Nishant Ganesh, Kung, Theodore A., Lee, Raphael C., Scott Levin, L., Li, Alexander Y., Lin, Walter C., Lombana, Nicholas F., Louie, Otway, Lucattelli, Elena, Maldonado, Andrés A., Miller, John D., Mohos, Balazs, Muthukumar, Vamseedharan, Narasiman, Venkateshwaran, Orfahli, Lynn M., Parikh, Rajiv P., Puri, Vinita, Raja Sabapathy, S., Said, Hakim, Safa, Bauback, Saint-Cyr, Michel H., Sauerbier, Michael, Sayyed, Adaah A., Schechter, Loren, Scott, Kaylee B., Raja Shanmugakrishnan, R., Sharif-Askary, Banafsheh, Song, David H., Song, Ping, Steinberg, John S., Suh, Hyunsuk Peter, Tang, Yueh-Bih, Tzou, Chieh-Han John, Vrouwe, Sebastian Q., Gabriel, Allen, Allen Sr., Robert J., Angrigiani, Claudio, Auclair, Eric Michel, Azoury, Saïd C., Baker, Nusaiba F., Bengtson, Bradley P., Bistoni, Giovanni, Blasdel, Gaines, Blondeel, Phillip, Bluebond-Langner, Rachel, Bolletta, Elisa, Bradley Calobrace, M., Calva-Cerquiera, Daniel, Cargile, John C., Chevray, Pierre, Chi, David, Choi, Vincent J., Cissell, Matthew, Colakoglu, Salih, Colwell, Amy S., Cortes, Raul A., Clemens, Mark W., Crowley, Connor, Deva, Anand, de Vita, Roy, Egro, Francesco M., Eom, Jin Sup, Farhadi, Jian, Glicksman, Caroline A., Gould, Daniel J., Grufman, Vendela, Haddock, Nicholas T., Hall-Findlay, Elizabeth J., Hamdi, Moustapha, Hammond, Dennis C., Han, Hyunho, Hauch, Adam T., Hofer, Stefan O.P., Irigo, Marcelo, Kanchwala, Suhail K., Karp, Nolan S., Keane, Grace, Khavanin, Nima, Khouri, Roger Khalil, Kim, John Y.S., Koesters, Emma C., Laun, Jake C., Mc Guire, Patricia, Ledo, Gustavo Jiménez Muñoz, O'Neill, Anne C., Piatkowski, Andrzej, Lentz, Rachel, Lipa, Joan E., Losken, Albert, Mallucci, Patrick, Manahan, Michele Ann, Masià, Jaume, Mays, Chester J., Maxwell, Patrick, Mc Ardle, Adrian, Mc Carthy, Colleen M., Munhoz, Alexandre, Mesbahi, Alex, Movassaghi, Kiya, Myckatyn, Terence M., Nava, Maurizio, Nahabedian, Maurice Y., Opsomer, Dries, Parikh, Janak A., Patel, Ketan M., Patel, Nakul Gamanlal, Pazmiño, Pat, Perez, Justin L., Pomata, Cristhian D., Ramakrishnan, Venkat V., Rancati, Agustin, Rancati, Alberto, Randquist, Charles, Rosson, Gedge D., Peter Rubin, J., Sacks, Justin M., Sanz, Javier, Hilaire, Hugo St., Salibian, Ara A., Sbitany, Hani, Shauly, Orr, Spiegel, Aldona J., Spring, Michelle, Stevens, Grant, Stewart, Christopher N., Tanna, Neil, Tenenbaum, Marissa, Teotia, Sumeet S., Tesfaye, Eliora A., Thekkinkattil, Dinesh, Venturi, Mark L., Vidya, Raghavan, Vieira, Brittany L., Michelina, Veronica Vietti, Wu, Liza C., Yemc, Louisa, Ahn, Hee Chang, Baumgartner, Rita E., Berger, Aaron, Berridge, Anna, Bindra, Randy R., Bini, Nathalie, Brandacher, Gerald, Brown, Amanda, Brown, Hazel, Calabrese, Sara, Calfee, Ryan P., Carr, Logan W., Chan, James K-K., Chang, James, Chase, Robert A., Chen, Shanlin, Chim, Harvey, Chong, Alphonsus K.S., Chuang, David Chwei-Chin, Coert, J. Henk, Cox, Christopher, Curtin, Catherine, Dahlin, Lars B., De, Soumen Das, Davidge, Kristen M., Dell, Paul C., Dengler, Jana, Dumanian, Gregory Ara, Farnebo, Simon, Fok, Margaret, Fox, Ida K., Fox, Paige M., Friedrich, Jeffrey B., Garcia, Brittany N., A. Goldfarb, Charles, Staines, Kimberly Goldie, Haas-Lützenberger, Elisabeth, Haase, Steven C., Harhaus, Leila, Hagert, Elisabet, Hammert, Warren C., Hazell, Dennis, Henta, Vincent, Hill, Jonay, Hentz, Vincent R., Jaloux, Charlotte, Jones, Neil F., Jordan, Sumanas W., Kakinoki, Ryosuke, Kang, Jason R., Ko, Jason Hyunsuk, Kulber, David A., Kumar, Bhaskaranand, Lalonde, Donald, Lam, Wee Leon, Leclerq, Caroline, Lee, Dong Chul, Andrew Lee, W.P., Legrand, Anais, Liao, Janice, Lopez, Christopher D., Lopez, Joseph, Lu, Johnny Chuieng-Yi, Mailey, Brian A., Mau, Minnie, Mc Cabe, Steven J., Mc Cullough, Meghan C., Megerle, Kai, Moore, Amy M., Moore, Wendy, Moran, Steven L., Nanchahal, Jagdeep, T. Netscher, David, Neumeister, Michael W., van Nieuwenhoven, Christianne A., Oberg, Kerby C., O'Brien, Andrew, Park, Eugene, Pet, Mitchell A., Prommersberger, Karl-Josef, Quick, Tom J., Ramanuj, Parashar, Reinholdt, Carina, Sammer, Douglas M., Sandvall, Brinkley K., Satteson, Ellen, Sen, Subhro K., Sharma, Pundrique, Shen, Xiao Fang, Shores, Jamie T., Singh, Vanila M., Smith, Gillian D., Tadisina, Kashyap K., Taghinia, Amir H., Tan, David M.K., Tang, Jin Bo, Thorfinn, Johan, Tian, Xiaofei, Tonkin, Michael, Upton, Joseph, Valero-Cuevas, Francisco J., Venkatramani, Hari, Vedder, Nicolas B., Yeung, Celine, Werker, Paul M.N., Yao, Jeffrey, and Yoon, Jung Soo

Published
2024
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33. Oncological and functional outcomes of pathological fractures of lower extremities in patients with malignant bone tumors.

Author

Hashimoto, Kazuhiko, Nishimura, Shunji, Ito, Tomohiko, Kakinoki, Ryosuke, and Goto, Koji

Subjects
SPONTANEOUS fractures, ARTIFICIAL bones, FEMUR neck, FRACTURE fixation, ORTHOPEDIC surgery, INTRAMEDULLARY rods
Abstract

As managing pathological fractures of the extremities can be difficult, the present study aimed to present a treatment algorithm for lower extremity bone malignancies. A total of 38 patients with impending and pathological fractures were treated at the Department of Orthopedic Surgery in Kindai University Hospital. Age, sex, fracture site, type of primary malignancy, number of metastases, pre-fracture Eastern Cooperative Oncology Group performance status (ECOG-PS) score, adjuvant therapy, treatment modality, operative time, blood loss, postoperative complications, Musculoskeletal Tumor Society (MSTS) score, outcomes, follow-up period and the MSTS scores and ECOG-PS were compared in cases of primary malignant tumors and those cases of metastatic malignant tumors were retrospectively surveyed. Post-treatment MSTS scores in cases of impending and pathological fractures were compared between intramedullary nail fixation and non-intramedullary nail fixation procedures. Disease sites included the sub-trochanteric femur in 10 patients, trochanteric femur in 8, femoral diaphysis in 7, femoral neck in 5, bilateral trochanteric femur in 3, proximal tibia in 3 and distal femur in 2 patients. A total of 10 patients had metastases between 3-20 sites. The median pre-fracture ECOG-PS score was 1. Adjuvant radiotherapy was administered to 5, chemotherapy to 8 and radiotherapy with chemotherapy to 10 patients. Surgical procedures included intramedullary nails in 18 patients, tumor arthroplasty in 4, plate fixation in 3, artificial head replacement in three, compression hip screw (CHS) in 3, conservative treatment in 2, bilateral intramedullary nail fixation in 2 and artificial bone stem with combined intramedullary nail and plate fixation, right-sided artificial head replacement and left-sided CHS in 1 patient each. The MSTS score was 19.9±8.95 for intramedullary nail fixation and 24.3±7.45 for other procedures, with a negative association between the MSTS score and pre-fracture ECOG-PS. The median follow-up period was 8 months. The outcomes were as follows: Alive with disease, 23 patients; continued disease-free, 1 patient; and dead due to disease, 14 patients. The 1-year postoperative overall survival rate was 60.5%. Moreover, the group with metastatic malignant tumors, which had significantly worse ECOG-PS, had significantly lower MSTS scores than the group with primary malignant tumors. The authors' treatment algorithm for malignant bone tumors of the lower extremity was shown to be useful. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Hand function and cost effectiveness after collagenase injection versus aponeurectomy for Dupuytren’s contracture: results of the CeCORD-J study

Author

Yamamoto, Michiro, primary, Yasunaga, Hideo, additional, Kakinoki, Ryosuke, additional, Tsubokawa, Naoto, additional, Morita, Akimasa, additional, Tanaka, Katsumi, additional, Sakai, Akinori, additional, Kurahashi, Toshikazu, additional, Hirata, Hitoshi, additional, Tatebe, Masahiro, additional, Onishi, Tetsuro, additional, Iwatsuki, Katsuyuki, additional, Tokutake, Katsuhiro, additional, Otani, Kazuhiro, additional, Menuki, Kunitaka, additional, Yamanaka, Yoshiaki, additional, Urata, Shiro, additional, Oguchi, Takeshi, additional, Iwasaki, Norimasa, additional, Matsui, Yuichiro, additional, Ikegami, Hiroyasu, additional, Sakano, Hiroaki, additional, Katsumura, Tetsu, additional, Nishiwaki, Masao, additional, Tanaka, Toshikazu, additional, Hirase, Yuichi, additional, Kanno, Yuri, additional, Kato, Hiroyuki, additional, Hayashi, Masanori, additional, Omokawa, Shohei, additional, Hasegawa, Hideo, additional, Gotani, Hiroyuki, additional, Tanaka, Yoshitaka, additional, Sunagawa, Toru, additional, Shinomiya, Rikuo, additional, Kajiwara, Rhoji, additional, Nakao, Etsuhiro, additional, Nishizuka, Takanobu, additional, Hattori, Yasunori, additional, Shinohara, Takaaki, additional, Watanabe, Kentaro, additional, Okui, Nobuyuki, additional, Koshima, Hiroshi, additional, Tajika, Tsuyoshi, additional, Ohi, Hiroyuki, additional, Kaji, Yoshio, additional, Nagayoshi, Eiichi, additional, and Igarashi, Ataru, additional

Published
2021
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47. Preoperative prediction of ambulatory status at 6 months after total hip arthroplasty

Author

Nankaku, Manabu, Tsuboyama, Tadao, Akiyama, Haruhiko, Kakinoki, Ryosuke, Fujita, Yasuko, Nishimura, Jun, Yoshioka, Yuji, Kawai, Haruna, and Matsuda, Shuichi

Subjects
Pain -- Care and treatment, Ambulatory medical care -- Management, Company business management, Health
Abstract

Background. Total hip arthroplasty (THA) is an effective procedure that provides patients with long-term relief from pain and enables them to resume their normal daily activities. Preoperative instruction about the functional outcomes and optimum goal of rehabilitation is helpful for patients undergoing THA. Objective. The purposes of this study were: (1) to examine the relationships between preoperative physical functions and ambulation following THA and (2) to identify optimal cutoff values for estimating ambulatory status at 6 months after THA. Design. This was a retrospective study. Methods. The study participants were 204 patients who underwent a unilateral THA. Hip abductor and knee extensor strength were measured and the Timed 'Up & Go' Test (TUG) was conducted preoperatively. The patients were divided into 2 groups according to serf-reported walking ability at 6 months postoperatively: an independent ambulation group (n=118) and a cane-assisted ambulation group (n=86). Differences between the 2 groups were examined using an unpaired t test or the chi-square test. A stepwise multiple logistic regression analysis was performed with walking ability at 6 months postoperatively as a dependent variable and age, sex, contralateral hip osteoarthritis (ie, whether a participant had contralateral hip osteoarthritis or not), body mass index, hip abductor strength, knee extensor strength, and TUG score as independent variables. Receiver operating characteristic curve analysis was used to identify a cutoff point for classifying the participants into the 2 groups. Results. A stepwise multiple logistic regression analysis selected 3 factors (age, knee extensor strength, and TUG score) as significant variables affecting the midterm ambulatory ability after THA. Moreover, receiver operating characteristic curve analyses revealed that the midterm (ie, 6-month) ambulatory status after THA was more accurately predicted by the patient's TUG score (cutoff point= 10 seconds, sensitivity=76.7%, specificity=93.2%, area under the curve=0.93) than by age and knee extensor strength. Limitations. The categorization of ambulatory status in this study was based solely on serf-reported walking ability. Conclusion. The findings indicate that patients with a preoperative TUG score of less than 10 seconds are likely to walk without an assistive device at 6 months after THA., Total hip arthroplasty (THA) is an orthopedic procedure performed to reduce pain and improve function in patients with osteoarthritis (OA) of the hip and to enable them to resume their [...]

Published
2013
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