94 results on '"Kakarala K"'
Search Results
2. Assessment of Nutritional and Imaging Biomarkers to Predict PEG Tube Placement in Non-HPV-Associated Head and Neck Patients Undergoing Concurrent Chemoradiotherapy
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Zitter, R., primary, Morse, R., additional, Ganju, R.G., additional, Gan, G.N., additional, Cao, Y., additional, Neupane, P., additional, Kakarala, K., additional, Shnayder, Y., additional, and Lominska, C.E., additional
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- 2022
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3. Anterolateral thigh butterfly free flap reconstruction for peristomal recurrence following laryngectomy: Our experience in six patients
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Durmus, K., Kakarala, K., Old, M. O., Teknos, T. N., and Ozer, E.
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- 2013
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4. Cetuximab Versus Other Non-Cisplatin Agents in the Treatment of Patients with Head and Neck Cancer Receiving Concurrent Chemoradiotherapy
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Morse, R., primary, Ganju, R.G., additional, Tennapel, M.J., additional, Neupane, P., additional, Kakarala, K., additional, Shnayder, L., additional, Bur, A., additional, and Lominska, C.E., additional
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- 2020
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5. A window of opportunity trial of atorvastatin targeting p53 mutant malignancies
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Baranda, J.C., primary, Bur, A., additional, Tsue, T., additional, Shnayder, L., additional, Kakarala, K., additional, Telfah, M., additional, Lin, T., additional, Williamson, S.K., additional, Al-Kasspooles, M., additional, Ashcraft, J., additional, Lakis, N., additional, Madan, R., additional, Khan, Q., additional, Saeed, A., additional, Reed, G., additional, Weir, S., additional, Godwin, A., additional, Thomas, S., additional, Komiya, T., additional, and Iwakuma, T., additional
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- 2019
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6. Skeletal Muscle Gauge Measured at the C3 Vertebral Body Predicts for Outcomes in Men with P16-Positive Oropharynx Cancer
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Ganju, R.G., primary, Morse, R., additional, Tennapel, M.J., additional, Hoover, A., additional, Kakarala, K., additional, Shnayder, L., additional, Bur, A., additional, and Lominska, C.E., additional
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- 2019
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7. Nutritional and Inflammatory Markers as Predictors for Chemoradiation Tolerance and Outcomes in Head and Neck Cancer
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Morse, R., primary, Ganju, R.G., additional, Tennapel, M.J., additional, Neupane, P., additional, Kakarala, K., additional, Shnayder, L., additional, Bur, A., additional, and Lominska, C.E., additional
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- 2019
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8. Distress is Common Among Head and Neck Cancer Patients, with Marriage Protective for Older but Not Younger Patients
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Lominska, C.E., primary, Hamilton, J., additional, Murray, L., additional, Neupane, P., additional, Shnayder, L., additional, Kakarala, K., additional, and Chen, A.M., additional
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- 2017
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9. 1978TiP - A window of opportunity trial of atorvastatin targeting p53 mutant malignancies
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Baranda, J.C., Bur, A., Tsue, T., Shnayder, L., Kakarala, K., Telfah, M., Lin, T., Williamson, S.K., Al-Kasspooles, M., Ashcraft, J., Lakis, N., Madan, R., Khan, Q., Saeed, A., Reed, G., Weir, S., Godwin, A., Thomas, S., Komiya, T., and Iwakuma, T.
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- 2019
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10. Cystic pilomatrixoma: a diagnostic challenge.
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Kakarala K, Brigger MT, Faquin WC, Hartnick CJ, and Cunningham MJ
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- 2010
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11. Impact of Adjuvant Radiotherapy Setting on Quality-of-Life in Head and Neck Squamous Cell Carcinoma.
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Alapati R, Wagoner SF, Lawrence A, Bon Nieves A, Desai A, Shnayder Y, Hamill C, Kakarala K, Neupane P, Gan G, Sykes KJ, and Bur AM
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- Humans, Male, Middle Aged, Female, Prospective Studies, Radiotherapy, Adjuvant, Aged, Surveys and Questionnaires, Quality of Life, Squamous Cell Carcinoma of Head and Neck radiotherapy, Squamous Cell Carcinoma of Head and Neck psychology, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms psychology
- Abstract
Objective: To determine differences in post-treatment QoL across treatment settings in patients receiving adjuvant radiation therapy for head and neck squamous cell carcinoma (HNSCC)., Methods: This was a prospective observational cohort study of patients with HNSCC initially evaluated in a head and neck surgical oncologic and reconstructive clinic at an academic medical center (AMC). Participants were enrolled prior to treatment in a prospective registry collecting demographic, social, and clinical data. Physical and social-emotional QoL (phys-QoL and soc-QoL, respectively) was measured using the University of Washington-QoL questionnaire at pre-treatment and post-treatment visits., Results: A cohort of 177 patients, primarily male and White with an average age of 61.2 ± 11.2 years, met inclusion criteria. Most patients presented with oral cavity tumors (n = 132, 74.6%), had non-HPV-mediated disease (n = 97, 61.8%), and were classified as Stage IVa (n = 72, 42.8%). After controlling for covariates, patients treated at community medical centers (CMCs) reported a 7.15-point lower phys-QoL compared with those treated at AMCs (95% CI: -13.96 to -0.35, p = 0.040) up to 12 months post-treatment. Additionally, patients who were treated at CMCs had a 5.77-point (-11.86-0.31, p = 0.063) lower soc-QoL score compared with those treated at an AMC, which was not statistically significant., Conclusion: This study revealed that HNSCC patients treated with radiation at AMCs reported significantly greater phys-QoL in their first-year post-treatment compared to those treated at CMCs, but soc-QoL did not differ significantly. Further observational studies are needed to explore potential factors, including treatment planning and cancer resource engagement, behind disparities between AMCs and CMCs., Level of Evidence: 3 Laryngoscope, 134:3645-3655, 2024., (© 2024 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2024
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12. Exploring the Role of Artificial Intelligence Chatbots in Preoperative Counseling for Head and Neck Cancer Surgery.
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Lee JC, Hamill CS, Shnayder Y, Buczek E, Kakarala K, and Bur AM
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- Humans, Cross-Sectional Studies, Patient Education as Topic methods, Preoperative Care methods, Internet, Head and Neck Neoplasms surgery, Artificial Intelligence, Counseling methods
- Abstract
Objective: To evaluate the potential use of artificial intelligence (AI) chatbots, such as ChatGPT, in preoperative counseling for patients undergoing head and neck cancer surgery., Study Design: Cross-Sectional Survey Study., Setting: Single institution tertiary care center., Methods: ChatGPT was used to generate presurgical educational information including indications, risks, and recovery time for five common head and neck surgeries. Chatbot-generated information was compared with information gathered from a simple browser search (first publicly available website excluding scholarly articles). The accuracy of the information, readability, thoroughness, and number of errors were compared by five experienced head and neck surgeons in a blinded fashion. Each surgeon then chose a preference between the two information sources for each surgery., Results: With the exception of total word count, ChatGPT-generated pre-surgical information has similar readability, content of knowledge, accuracy, thoroughness, and numbers of medical errors when compared to publicly available websites. Additionally, ChatGPT was preferred 48% of the time by experienced head and neck surgeons., Conclusion: Head and neck surgeons rated ChatGPT-generated and readily available online educational materials similarly. Further refinement in AI technology may soon open more avenues for patient counseling. Future investigations into the medical safety of AI counseling and exploring patients' perspectives would be of strong interest., Level of Evidence: N/A. Laryngoscope, 134:2757-2761, 2024., (© 2023 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2024
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13. Six-week postoperative opioid use and pain following a randomized controlled trial evaluating multimodal analgesia for head and neck free flap patients.
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Wagoner SF, Lawrence AS, Alapati R, Renslo B, Hamill CS, Bon Nieves A, Baumanis M, Bur AM, Kakarala K, Sykes KJ, and Shnayder Y
- Abstract
Introduction: Head and neck malignancy treatment often involves invasive surgeries, necessitating effective postoperative pain control. However, chronic reliance on opioid medications remains a challenge for many patients after surgery. Multimodal analgesia (MMA) within enhanced recovery after surgery protocols has shown success in limiting narcotic pain medications for other cancer types. In a prior study, MMA comprising acetaminophen, ketorolac, gabapentin, and a neurogenic block reduced opioid use in the 7-day postoperative period for major head and neck reconstructive surgery. This study investigates the impact of multimodal analgesia on opioid prescription and pain during the 6-week postoperative period for patients undergoing major head and neck oncologic surgeries, aiming to understand the longer-term effects of narcotic use., Methods: The study retrospectively examined participants in a [hybrid type 1 effectiveness-implementation pragmatic trial to assess multimodal analgesia's long-term effectiveness in head and neck free flap surgery. Arm A received scheduled acetaminophen and as-needed opioids, while Arm B received scheduled gabapentin, ketorolac, a regional nerve block at the donor site, scheduled acetaminophen, and as-needed opioids. Retrospective data collection included opioid prescription use and pain scores up to 6 weeks after surgery, gathered from the Kansas prescription drug monitoring program, K-TRACS., Results: Thirty patients participated, 14 in Arm A and 16 in Arm B. The average morphine milligram equivalents per day of filled prescriptions were not significantly different between Arm A and Arm B (7.23 vs. 7.88, p = .845). Additionally, average pain scores at 6 weeks showed no significant difference between the two groups (1.4 vs. 1.9, p = .612)., Conclusion: Patients with head and neck cancer treated with multimodal analgesia during the perioperative period did not exhibit significant differences in opioid use and pain within 6 weeks after discharge. To confirm these findings, a re-examination with strict measures of opioid use and scheduled pain assessments in a prospective manner is warranted., Level of Evidence: 4., Competing Interests: The authors declare no conflicts of interest., (© 2024 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.)
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- 2024
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14. Oncologic Safety of Close Margins in Patients With Low- to Intermediate-Grade Major Salivary Gland Carcinoma.
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Sajisevi M, Nguyen K, Callas P, Holcomb AJ, Vural E, Davis KP, Thomas CM, Plonowska-Hirschfeld KA, Stein JS, Eskander A, Kakarala K, Enepekides DJ, Hier MP, Ryan WR, Asarkar AA, Aulet R, Bell RK, Blasco MA, Bowmaster VB, Burruss CP, Chung J, Chan K, Chang BA, Coffey CS, Cognetti DM, Cooper DJ, Cordero J, Donovan J, Du YJ, Dundar Y, Dedivitis RA, Edwards HA, Erovic BM, Feinberg PA, Garvey EA, Goldstein DP, Goodman JF, Goulart RN, Goyal N, Grasl S, Giurintano JP, Gupta N, Habib AM, Hackman TG, Hara JH, Henson C, Hinni ML, Hua N, Johnson-Obaseki S, Juloori A, Kalman NS, Kejner AE, Khaja SF, Ku JA, Lambert A, Luu BK, Magliocca KR, Dos Santos LRM, Michael C, Miles BA, de Melo GM, Moore MG, Morand GB, Moura K, Mukdad L, Noroozi H, Patel R, Paydarfar JA, Sadeghi N, Savaria FN, Schmitt NC, Shapiro J, Shaver TB, Stoeckli SJ, St John M, Stokes WA, Sulibhavi A, Tasoulas J, Vendra V, Vinh DB, Virgen CG, Wooten C, Woody NM, and Young GD
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- Humans, Male, Female, Infant, Adult, Middle Aged, Aged, Retrospective Studies, Cohort Studies, Margins of Excision, Carcinoma surgery, Salivary Gland Neoplasms radiotherapy, Salivary Gland Neoplasms surgery, Salivary Gland Neoplasms pathology
- Abstract
Importance: Postoperative radiation therapy for close surgical margins in low- to intermediate-grade salivary carcinomas lacks multi-institutional supportive evidence., Objective: To evaluate the oncologic outcomes for low- and intermediate-grade salivary carcinomas with close and positive margins., Design, Setting, and Participants: The American Head and Neck Society Salivary Gland Section conducted a retrospective cohort study from 2010 to 2019 at 41 centers. Margins were classified as R0 (negative), R1 (microscopically positive), or R2 (macroscopically positive). R0 margins were subclassified into clear (>1 mm) or close (≤1 mm). Data analysis was performed from June to October 2023., Main Outcomes and Measures: Main outcomes were risk factors for local recurrence., Results: A total of 865 patients (median [IQR] age at surgery, 56 [43-66] years; 553 female individuals [64%] and 312 male individuals [36%]) were included. Of these, 801 (93%) had parotid carcinoma and 64 (7%) had submandibular gland carcinoma, and 748 (86%) had low-grade tumors and 117 (14%) had intermediate-grade tumors, with the following surgical margins: R0 in 673 (78%), R1 in 168 (19%), and R2 in 24 (3%). Close margins were found in 395 of 499 patients with R0 margins (79%), for whom margin distances were measured. A total of 305 patients (35%) underwent postoperative radiation therapy. Of all 865 patients, 35 (4%) had local recurrence with a median (IQR) follow-up of 35.3 (13.9-59.1) months. In patients with close margins as the sole risk factor for recurrence, the local recurrence rates were similar between those who underwent postoperative radiation therapy (0 of 46) or observation (4 of 165 [2%]). Patients with clear margins (n = 104) had no recurrences. The local recurrence rate in patients with R1 or R2 margins was better in those irradiated (2 of 128 [2%]) compared to observed (13 of 64 [20%]) (hazard ratio [HR], 0.05; 95% CI, 0.01-0.24). Multivariable analysis for local recurrence found the following independent factors: age at diagnosis (HR for a 10-year increase in age, 1.33; 95% CI, 1.06-1.67), R1 vs R0 (HR, 5.21; 95% CI, 2.58-10.54), lymphovascular invasion (HR, 4.47; 95% CI, 1.43-13.99), and postoperative radiation therapy (HR, 0.10; 95% CI, 0.04-0.29). The 3-year local recurrence-free survivals for the study population were 96% vs 97% in the close margin group., Conclusions and Relevance: In this cohort study of patients with low- and intermediate-grade major salivary gland carcinoma, postoperative radiation therapy for positive margins was associated with decreased risk of local recurrence. In isolation from other risk factors for local recurrence, select patients with close surgical margins (≤1 mm) may safely be considered for observation.
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- 2024
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15. Assessing the Risk of Adjuvant Radiotherapy Initiation Delays With Social Support Surveys.
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Renslo B, Sawaf T, Virgen CG, Farrokhian N, Yu KM, Somani SN, Penn J, Ziegler A, Gan GN, Kakarala K, Shnayder Y, Bur AM, and Sykes KJ
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- Humans, Squamous Cell Carcinoma of Head and Neck, Radiotherapy, Adjuvant, Prospective Studies, Social Support, Retrospective Studies, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms surgery
- Abstract
Objective: In patients with head and neck squamous cell carcinoma (HNSCC), initiating postoperative radiotherapy (PORT) greater than 42 days after surgery is associated with a higher risk of poor survival outcomes. Social support has been shown to modulate behaviors related to care-seeking and treatment adherence. In this study, we sought to determine the relationship between social support metrics and PORT delays., Study Design: Prospective cohort study., Setting: Single tertiary medical center., Methods: Patients with HNSCC who underwent primary surgical excision requiring PORT were prospectively enrolled. Patient-perceived social support metrics were assessed using the Medical Outcomes Study Social Support Survey (MOS-SSS) at initial presurgical evaluation. Associations with PORT delays were evaluated via univariable and multivariable logistic regression analysis., Results: A total of 111 patients met the inclusion criteria for the study. An additional 28 patients were recommended to receive PORT but did not initiate treatment and were included for secondary analysis. All four subscales of the MOS-SSS (positive social interaction, affectionate support, tangible support, and emotional/informational support) were significantly associated with PORT initiation delays on univariable analysis. On multivariable analysis, the overall MOS-SSS score (odds ratio [OR] 2.08, 1.15-4.35, p = .028) was significantly associated with PORT initiation delays. On secondary analysis, lower tangible support was associated with a lack of PORT initiation (OR 1.63, 1.05-2.54, p = .028)., Conclusion: Social support metrics were significantly associated with PORT delays, which may help promote tighter scheduling and closer monitoring of high-risk patients., (© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.)
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- 2023
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16. Team Consistency in Reducing Operative Time in Head and Neck Surgery with Microvascular Free Flap Reconstruction.
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Sawaf T, Renslo B, Virgen C, Farrokhian N, Yu KM, Gessert TG, Jackson C, O'Neill K, Sperry B, and Kakarala K
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- Humans, Retrospective Studies, Operative Time, Postoperative Complications, Free Tissue Flaps blood supply, Head and Neck Neoplasms surgery
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Objective(s): To evaluate the impact of consistent surgical teams on procedure duration in head and neck free tissue transfer, and to evaluate the length of stay and readmission rates with consistent teams., Methods: A retrospective chart review of head and neck microvascular reconstruction by a single surgeon between August 2017 and November 2021 was performed. Procedure duration, wound complications, length of stay, and 30-day readmissions were analyzed. One circulating nurse (CN) and surgical technologist (ST) were considered "consistent" due to their prior work with the primary surgeon. All others were considered "ad hoc." Teams were "Consistent CN + ST," "Consistent ST," "Consistent CN," or "Ad hoc." Procedure duration between groups was compared via analysis of variance. Multivariate linear regression was performed to predict procedure duration., Results: A total of 135 patients were included. Age, sex, and American Society of Anesthesiologists status did not significantly differ across groups (p = 0.963; p = 0.467; p = 0.908, respectively). The mean procedure duration was 339.3 min and differed significantly across all groups (p = 0.006, Cohen d = 0.32). Compared to the Ad hoc group, consistent teams demonstrated significant reductions in mean procedure duration (Consistent CN + ST: 58.4 min, p = 0.001, Cohen d = 0.67; Consistent ST: 51.6 min, p = 0.013, Cohen d = 0.61; Consistent CN: 44.5 min, p = 0.031, Cohen d = 0.52). Controlling for other factors, the ad hoc team predicted increased procedure duration on multivariate analysis ( β 57.38, 19.92-94.85, p < 0.003). Wound complications, length of stay, and readmission rates did not differ significantly across groups (p = 0.940; p = 0.174; p = 0.935, respectively)., Conclusion: Consistent CN and ST improve operative efficiency in head and neck-free tissue transfer. Future studies may evaluate the impact of team consistency on complications, physician burnout, and health systems costs., Level of Evidence: 3 Laryngoscope, 133:2154-2159, 2023., (© 2023 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2023
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17. The Innovative Art of Reconstruction in Otolaryngology.
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Stevens JR and Kakarala K
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- Humans, Nose, Pharynx, Otolaryngology
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- 2023
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18. Improving Quality and Value in Head and Neck Reconstruction.
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Kakarala K, Mifsud M, and Dziegielewski P
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- Humans, Consensus, Perioperative Care, Quality Improvement, Head, Neck
- Abstract
Multiple advances in surgical techniques, technology, and perioperative patient care have revolutionized head and neck reconstruction over the last 40 years. Concurrent with these advances, health systems, patients, and payers have become increasingly focused on value and quality, owing in part to rapidly increasing health care costs. However, there is no consensus on how to define value and quality in the realm of head and neck reconstruction. This review focuses on the past, present, and future of quality improvement efforts in head and neck reconstruction., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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19. Disentangling Social Determinants of Health and Rurality in Head and Neck Cancer 2-Year Mortality.
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Virgen C, Renslo B, Sawaf T, Shnayder Y, Kakarala K, Bur AM, and Sykes KJ
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Social determinants of health (SDoH) and rurality are known factors that may influence outcomes in head and neck squamous cell carcinoma (HNSCC). Patients residing in remote locations or those with multiple SDoH may encounter barriers to initial diagnosis, adherence to multidisciplinary treatments, and posttreatment surveillance, which may impact their overall survival. However, previous studies have shown mixed results associated with rural residence. The aim of this study is to identify the impact of rurality and SDoH on 2-year survival in HNSCC. The study was conducted using a Head and Neck Cancer Registry at a single institution from June 2018 through July 2022. Rurality, defined by US census scores, and individual measures of SDoH were used. Our results indicate that each additional adverse SDoH factor results in 1.5 times the odds of mortality at 2 years. Individualized measures of SDoH, rather than rurality alone, better reflect patient prognosis in HNSCC., Competing Interests: None., (© 2023 The Authors. OTO Open published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology–Head and Neck Surgery Foundation.)
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- 2023
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20. Adjuvant radiotherapy mitigates impact of perineural invasion on oncologic outcomes in early-stage oral cavity squamous cell carcinoma. A multi-institutional analysis of 557 patients.
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Holcomb AJ, Farrokhian N, Tolan C, Whiteford E, Villwock M, Kakarala K, Shnayder Y, Sykes K, Lominska C, Gan G, Buchakjian MR, Harding B, Dooley L, Shinn J, Burton Wood C, Rohde S, Khaja S, Abt NB, Varvares M, and Bur AM
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- Humans, Female, Middle Aged, Male, Squamous Cell Carcinoma of Head and Neck pathology, Cohort Studies, Retrospective Studies, Prognosis, Radiotherapy, Adjuvant, Neoplasm Invasiveness pathology, Neoplasm Staging, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell surgery, Mouth Neoplasms radiotherapy, Mouth Neoplasms surgery, Head and Neck Neoplasms pathology
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Objectives: Understand the prognostic impact of perineural invasion (PNI) in early-stage oral cavity squamous cell carcinoma (OCSCC). Assess the influence of adjuvant radiotherapy on outcomes of patients with PNI-positive early-stage OCSCC., Materials and Methods: Retrospective seven-institution cohort study including patients with pathologic T1-2 N0-1 OCSCC who underwent primary surgery with negative margins. Outcomes included disease-free survival (DFS) and locoregional control (LRC). Cox proportional hazards models were used to evaluate oncologic outcomes. Interaction terms were introduced to assess relationships between PNI and adjuvant radiotherapy., Results: Among 557 patients (mean (SD) age 61.0 (13.9), 47.2% female, 66.6% pathologic T1, 93.5% pathologic N0), 93 had PNI-positive tumors, among which 87.1% underwent neck dissection and 39.6% received radiotherapy. On multivariable analysis, PNI was associated with lower DFS and LRC. Adjuvant radiotherapy was not associated with improved outcomes on multivariable analysis of the entire cohort. However, among patients with PNI-positive tumors, adjuvant radiotherapy significantly decreased hazard for DFS., Conclusion: Among patients with low-risk, early-stage OCSCC, PNI was associated with worse DFS and LRC. In patients with PNI-positive tumors, adjuvant radiotherapy lowered hazard for DFS on multivariable analysis. These data support using adjuvant radiotherapy for patients with early-stage OCSCC with PNI., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
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- 2023
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21. Prognostic Implications of Skin Invasion in Locally Advanced Oral Cavity Squamous Cell Carcinoma.
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Diebolt JH, Yu KM, Wood S, Ziegler A, France A, Villwock MR, Alvi SA, Kakarala K, Shnayder Y, Gan GN, Lominska CE, Neupane P, and Bur AM
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- Humans, Prognosis, Squamous Cell Carcinoma of Head and Neck, Retrospective Studies, Case-Control Studies, Carcinoma, Squamous Cell pathology, Mouth Neoplasms pathology, Head and Neck Neoplasms
- Abstract
Objective: To evaluate the effect of histopathologic skin invasion on 2- and 5-year disease-free survival (DFS) and overall survival (OS) in patients treated with primary surgery for locally advanced oral cavity squamous cell carcinoma (OCSCC)., Study Design: A retrospective case-control study was performed comparing previously untreated patients with pT4a OCSCC with and without skin invasion., Setting: Academic medical center., Methods: Propensity score-matched cohorts were derived by age, sex, surgical margins, pathologic N classification, adjuvant treatment, and primary tumor site. The Kaplan-Meier method was used to evaluate 2- and 5-year OS and DFS, which were compared between cohorts via the log rank (Mantel-Cox) test statistic., Results: Overall 25 patients were identified to have pathologic skin invasion, and 50 were selected for the matched control group. OS was significantly lower for patients with skin invasion as compared with controls at 2 years (30.8% vs 53.3%, P = .018) and 5 years (16.6% vs 42.2%, P = .01). DFS was significantly lower for patients with skin invasion vs controls at 2 years (23.7% vs 47.7, P = .037) and 5 years (15.8% vs 41.4%, P = .024)., Conclusion: Histopathologic skin invasion in OCSCC is associated with dismal prognosis in patients who underwent primary surgical treatment. OS outcomes for patients with skin invasion are comparable to survival of patients with recurrent/metastatic disease and T4N2 disease., (© 2022 American Academy of Otolaryngology-Head and Neck Surgery Foundation.)
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- 2023
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22. Association of Social-Ecological Factors With Delay in Time to Initiation of Postoperative Radiation Therapy: A Prospective Cohort Study.
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Sawaf T, Virgen CG, Renslo B, Farrokhian N, Yu KM, Somani SN, Bur AM, Kakarala K, Shnayder Y, Gan GN, Graboyes EM, and Sykes KJ
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- Male, Adult, Humans, Middle Aged, Female, Squamous Cell Carcinoma of Head and Neck, Cohort Studies, Prospective Studies, Retrospective Studies, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms surgery
- Abstract
Importance: Timely initiation of postoperative radiation therapy (PORT) is associated with reduced recurrence rates and improved overall survival in patients with head and neck squamous cell carcinoma (HNSCC). Measurement of the association of social-ecological variables with PORT delays is lacking., Objective: To assess individual and community-level factors associated with PORT delay among patients with HNSCC., Design, Setting, and Participants: This prospective cohort study carried out between September 2018 and June 2022 included adults with untreated HNSCC who were enrolled in a prospective registry at a single academic tertiary medical center. Demographic information and validated self-reported measures of health literacy were obtained at baseline visits. Clinical data were recorded, and participant addresses were used to calculate the area deprivation index (ADI), a measure of community-level social vulnerability. Participants receiving primary surgery and PORT were analyzed. Univariable and multivariable regression analysis was performed to identify risk factors for PORT delays., Exposures: Surgical treatment and PORT., Main Outcomes and Measures: The primary outcome was PORT initiation delay (>42 days from surgery). Risk of PORT initiation delay was evaluated using individual-level (demographic, health literacy, and clinical data) and community-level information (ADI and rural-urban continuum codes)., Results: Of 171 patients, 104 patients (60.8%) had PORT delays. Mean (SD) age of participants was 61.0 (11.2) years, 161 were White (94.2%), and 105 were men (61.4%). Insurance was employer-based or public among 65 (38.5%) and 75 (44.4%) participants, respectively. Mean (SD) ADI (national percentile) was 60.2 (24.4), and 71 (41.8%) resided in rural communities. Tumor sites were most commonly oral cavity (123 [71.9%]), with 108 (63.5%) classified as stage 4 at presentation. On multivariable analysis, a model incorporating individual-level factors with health literacy in addition to community-level factors was most predictive of PORT delay (AOC= 0.78; R2, 0.18)., Conclusions and Relevance: This cohort study provides a more comprehensive assessment of predictors of PORT delays that include health literacy and community-level measures. Predictive models that incorporate multilevel measures outperform models with individual-level factors alone and may guide precise interventions to decrease PORT delay for at-risk patients with HNSCC.
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- 2023
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23. The Use of Dissemination and Implementation to Improve Multimodal Analgesia in Head and Neck Surgery.
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Shnayder Y, Baumanis MM, Brown A, Reese A, Bur AM, Kakarala K, and Sykes KJ
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- Humans, Ketorolac, Gabapentin, Pilot Projects, Pain, Postoperative drug therapy, Pain, Postoperative prevention & control, Pain, Postoperative etiology, Analgesics, Opioid therapeutic use, Acetaminophen therapeutic use, Analgesia methods
- Abstract
Objectives: To optimize the delivery of multimodal analgesia to patients undergoing major head and neck oncologic surgeries., Methods: Pilot study included patients enrolled to receive either scheduled acetaminophen and as-needed opioids (control group) or scheduled acetaminophen, gabapentin, ketorolac, and as-needed opioids (experimental group). RCT, a hybrid type 1 effectiveness-implementation pragmatic trial, was designed to test the effectiveness of the intervention. Arm A received scheduled acetaminophen and as-needed opioids. Arm B received scheduled gabapentin, ketorolac, a regional nerve block at the free tissue donor site, scheduled acetaminophen and as-needed opioids., Results: Pilot: Thirty-one patients undergoing major head and neck surgery were enrolled. Mean MMEs administered in control group (n = 15) was 251.60 mg (SD = 224.57 mg); mean MMEs in Experimental group (n = 16) was 195.78 mg (SD = 131.08 mg), p = 0.401. LOS was 8.0 days in control versus 7.0 days in experimental group (p = 0.054). RCT: Interim analysis for safety and futility was planned during trial's design after 30 patients (n = 14 Arm A, and n = 16 Arm B). Mean MMEs administered were 135.1 mg in Arm A, (SD = 86.0 mg) versus mean MME of 51.3 mg in Arm B (SD = 43.3 mg, (p < 0.05)). Given clear superiority results, the trial was prematurely terminated. Functional pain scores, LOS, and complications were similar between the arms (p > 0.05). Variability of mean MME was compared before and after implementation of the management protocols: SD in RCT#1 was 181.46 mg versus 124.6 mg in RCT#2., Conclusion: Multimodal analgesia significantly reduced the need for opioids in patients undergoing major head and neck surgery., Level of Evidence: 1, Randomized Clinical Trial Laryngoscope, 133:S1-S11, 2023., (© 2022 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2023
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24. Preoperative Examination Is Not Associated with Postoperative Function following Radial Forearm Free Flap Harvest.
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Emanuelli E, Egan KG, Bins G, Nazir N, Bur AM, Kakarala K, Przylecki W, and Endress R
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- Humans, Retrospective Studies, Tissue Donors, Hand, Free Tissue Flaps, Plastic Surgery Procedures adverse effects
- Abstract
Background: There is debate on the utility of a preoperative Allen test or ultrasound before radial forearm free flap (RFFF) harvest. This study sought to evaluate correlations between preoperative testing and donor-site morbidity., Methods: A survey of plastic surgery and otolaryngology RFFF patients was conducted at a Midwestern academic center. The modified Cold Intolerance Symptom Severity (modCISS) and Quick Disabilities of the Arm, Shoulder, and Hand (QDASH) instruments were administered. A retrospective chart review was performed to assess perioperative factors., Results: Of 212 RFFFs completed over 7 years, 144 patients were contacted, and 71 patients completed the survey (33% response rate). Preoperative Allen test was negative in 92% of patients (65 of 71). There was no statistical association between Allen test and duplex ultrasound findings ( P = 0.19). Cold intolerance screening was positive on 20% of donor arms (14 of 71), with an average positive modCISS score of 39.0 ± 14.7. Disability was reported on the QDASH by 76% of patients (54 of 71), with an average score of 21.0 ± 22.3. There was no statistical correlation between preoperative Allen test or ultrasound classification and modCISS or QDASH score. There was a borderline positive correlation between modCISS and QDASH scores that did not reach statistical significance ( r = 0.22, P = 0.067). Operative characteristics also did not predict modCISS or QDASH scores., Conclusions: Following RFFF harvest, donor extremity cold intolerance is reported in 20% of patients, and extremity-related disability is reported in the majority of patients. Preoperative ultrasound and physical examination findings are not predictive of morbidity., (Copyright © 2022 by the American Society of Plastic Surgeons.)
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- 2023
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25. A Multi-institutional Analysis of Late Complications in Scapula, Fibula, and Osteocutaneous Radial Forearm Free Flaps.
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Bollig CA, Walia A, Pipkorn PJ, Jackson RS, Puram SV, Rich JT, Paniello RC, Zevallos JP, Stevens MN, Wood CB, Rohde SL, Sykes K, Kakarala K, Bur A, Wieser ME, Galloway TLI, Tassone P, Sadeghi J, Mattingly TR, Pluchino T, and Jorgensen JB
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- Humans, Retrospective Studies, Radius, Fibula, Postoperative Complications epidemiology, Free Tissue Flaps, Plastic Surgery Procedures adverse effects
- Abstract
Objectives: (1) Evaluate the association of flap type with late complications in patients undergoing osseous head and neck reconstruction with the fibula free flap (FFF), osteocutaneous radial forearm free flap (OCRFFF), and scapula free flap (SFF). (2) Compare the prevalence of late complications based on minimum duration of follow-up., Study Design: Retrospective cohort study., Setting: Multiple academic medical centers., Methods: Patients undergoing FFF, OCRFFF, or SFF with ≥6-month follow-up were stratified by type of flap performed. The association of flap type with late complications was analyzed via univariable and multivariable logistic regression, controlling for relevant clinical risk factors. Additionally, the frequency of late complications by minimum duration of follow-up was assessed., Results: A total of 617 patients were analyzed: 312 (50.6%) FFF, 230 (37.3%) OCRFFFF, and 75 (12.2%) SFF. As compared with the SFF, the FFF (adjusted odds ratio [aOR], 3.05; 95% CI, 1.61-5.80) and OCRFFF (aOR, 2.17; 95% CI, 1.12-4.22) were independently associated with greater odds of overall late recipient site wound complications. The SFF was independently associated with the lowest odds of hardware exposure when compared with the FFF (aOR, 2.61; 95% CI, 1.27-5.41) and OCRFFF (aOR, 2.38; 95% CI, 1.11-5.12). The frequency of late complications rose as minimum duration of follow-up increased until plateauing at 36 months., Conclusions: This multi-institutional study suggests that the long-term complication profile of the SFF and OCRFFF compares favorably to the FFF. The SFF may be associated with the fewest overall late recipient site complications and hardware exposure, while the FFF may be associated with the most of these 3 options., (© 2022 American Academy of Otolaryngology-Head and Neck Surgery Foundation.)
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- 2023
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26. Angle of BRINK - a new way to measure Haglund's deformity.
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Nischal N, Chandra Lalita K, Iyengar KP, Reilly I, and Botchu R
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- Humans, Retrospective Studies, Reproducibility of Results, Achilles Tendon, Exostoses, Bursitis, Calcaneus diagnostic imaging
- Abstract
Introduction: Haglund's deformity, an abnormality of the postero-superior corner of the calcaneum, is a common, critically debated cause of posterior heel pain. Several radiological indices such as Fowler-Philip angle, Ruch pitch, Chauveaux-Liet angle, calcaneal pitch angle, parallel pitch lines, and X-Y ratio have been described to measure this deformity. However, most of these lack specificity and have variable intra- and inter-observer reliability., Purpose: The study aims to describe a new radiological "angle of BRINK" (Botchu-Reilly-Iyengar-Nischal-Kakarala) to measure Haglund's deformity., Patient and Methods: We performed a retrospective cohort analysis, assessing 20 weight-bearing lateral ankle radiographs of patients with Haglund's deformity (Haglund's cohort) and 100 radiographs without the deformity (normal cohort). Demographic details and angle of BRINK to measure Haglund's deformity were measured for each patient. Statistical analysis was performed using t-test and inter-observer reliability was calculated using kappa coefficient., Results: The mean angle of BRINK to measure Haglund's deformity in the normal cohort was 20.04° (SD 4.88), and in the Haglund's cohort was 25.1° (SD 3.3). This was statistically significant with a p-value of less than 0.0001. There was excellent intra- and inter-observer reliability with kappa value of 0.8., Conclusion: Our proposed radiological angle of BRINK to measure Haglund's deformity is simple and easy to calculate on standard weight-bearing radiographs. Contrary to the traditional measurements used to estimate the deformity, it has shown a good intra- and inter-observer reliability and can support surgical decision-making process for management of patients with symptomatic Haglund's deformity., (© 2022. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2023
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27. Post-operative Outcomes in Pediatric Patients Following Facial Reconstruction With Fibula Free Flaps.
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Slijepcevic AA, Wax MK, Hanasono M, Ducic Y, Petrisor D, Thomas CM, Shnayder Y, Kakarala K, Pipkorn P, Puram SV, Rich J, Rezaee R, Pittman A, and Troob S
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- Child, Humans, Bone Transplantation, Mandible surgery, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications surgery, Retrospective Studies, Free Tissue Flaps surgery, Mandibular Neoplasms surgery, Mandibular Reconstruction, Plastic Surgery Procedures adverse effects
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Educational Objective: Assess outcomes of pediatric facial reconstruction with fibula free flaps., Objectives: Free flap reconstruction of complex maxillofacial defects in pediatric patients is rare. Post-operative complications, donor site morbidity, impact on craniofacial growth, and oro-dental rehabilitation are unknown. Our study assesses the outcomes of pediatric maxillofacial reconstruction with composite fibula free flaps., Study Design: Retrospective chart review., Methods: Multi-institutional retrospective chart review from 2000 to 2020 on pediatric patients undergoing maxillomandibular reconstruction with fibula free flaps., Results: Eighty-seven patients underwent 89 surgeries; 5 maxillary and 84 mandibular defects. Median age: 12 years. Defects were acquired following resection of sarcoma/carcinoma 44% or benign tumors 50%. 73% of cases had immediate free flap reconstruction. Closing osteotomies were reported in 74%; 1 in 40%, 2 in 27%, and more than 2 in 6.7%. Hardware was used in 98% and removed in 25%. 9.2% demonstrated long-term hardware exposure, greater than 3 months following reconstruction. Short-term complications: wound infection 6.7%, flap salvage/failure 2.2%, fistula 1.1%, and compromised craniofacial growth: 23%. Two patients developed trismus. Long-term fibula donor site complications: hypertrophic scarring: 3.4%, dysesthesia: 1.1%, and long-term gait abnormality: 1.1%. Dental rehabilitation was performed in 33%. Post-operative speech outcomes showed 94% with fully intelligible speech., Conclusion: Pediatric maxillary and mandible defects repaired with fibula free flaps demonstrated complication rates comparable to the adult free flap population. Long-term follow-up did not demonstrate adverse outcomes for craniofacial growth. Hardware for flap retention was utilized and remained in place with minimal exposure. Post-operative gait abnormality is rare., Level of Evidence: 3 Laryngoscope, 133:302-306, 2023., (© 2022 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2023
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28. Pilot randomized, controlled, preoperative intervention for nutrition trial in head and neck cancer.
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Sykes KJ, Gibbs H, Farrokhian N, Arthur A, Flynn J, Shnayder Y, Kakarala K, Nallani R, Smith JB, Penn J, Fassas S, Cummings E, Arambula Z, Karadaghy O, and Bur AM
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- Humans, Prospective Studies, Quality of Life, Nutritional Status, Weight Loss, Head and Neck Neoplasms surgery, Deglutition Disorders etiology, Deglutition Disorders therapy
- Abstract
Background: Several prospective studies report improved outcomes with pretreatment nutrition interventions prior to radiation therapy for head and neck cancer (HNC), but none have assessed similar interventions before surgery for HNC., Methods: POINT, a pilot randomized controlled trial, was conducted to evaluate a multimodal nutrition intervention. Patients undergoing primary surgery with free flap reconstruction for HNC were randomly assigned to the control arm or a preoperative multimodal nutrition intervention., Results: POINT included 49 patients. Nutrition risk scores did not change significantly for either the intervention or control group. Control patients had a significant decrease in body weight in the preoperative period (p < 0.001). Conversely, weight among intervention patients did not significantly decrease (p = 0.680). The intervention mitigated weight loss in patients with dysphagia (p = 0.001)., Conclusions: Preoperative nutrition optimization shows potential to reduce weight loss normally experienced by patients with head and neck cancer prior to surgical extirpation, especially among those with subjective dysphagia., (© 2022 Wiley Periodicals LLC.)
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- 2023
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29. Treatment Tolerance of Cetuximab versus Alternative Chemotherapy Agents in Non-Cisplatin Candidates with Head and Neck Cancer Receiving Concurrent Chemoradiotherapy.
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Morse RT, Ganju RG, Neeranjun R, Gan GN, Cao Y, Neupane P, Kakarala K, Shnayder Y, and Lominska CE
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- Humans, Chemoradiotherapy, Cisplatin therapeutic use, Treatment Outcome, Antineoplastic Agents adverse effects, Cetuximab adverse effects, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms therapy, Squamous Cell Carcinoma of Head and Neck drug therapy, Squamous Cell Carcinoma of Head and Neck therapy
- Abstract
Introduction: Standard of care for radiosensitization in head and neck squamous cell carcinoma (HNSCC) is concurrent chemoradiotherapy (CCRT) with high-dose cisplatin. The optimal chemoradiation regimen for patients medically unfit for cisplatin is unclear. We compared our experience with concurrent cetuximab (CTX) versus other cytotoxic non-cisplatin agents., Methods: We reviewed 53 patients between 2011 and 2017 with HNSCC treated with CCRT ineligible for cisplatin. Chemotherapy and radiotherapy treatment tolerance was evaluated in those receiving CTX versus non-CTX chemotherapy (NCC). Of the NCC regimens, the majority were carboplatin/paclitaxel and were dosed at an area under the curve (AUC) of 2 and 45-50 mg/m2, respectively. Standard radiation dosing was 70 Gray (Gy) in the definitive setting and 60-66 Gy in the postoperative setting. Patient characteristics and treatment toxicities were evaluated using categorical methods., Results: Patients were well balanced overall including differences between performance status and the comorbidity score. NCC patients experienced more radiation treatment breaks (52.4% vs. 21.9%, p = 0.022), radiation delays >1 week (33.3% vs. 3.1%, p < 0.01), and chemotherapy dose-limiting toxicity (61.9% vs. 28.1%, p = 0.015) compared to CTX patients. Nutritional dependence on a PEG tube was more likely in the NCC cohort (52.4% vs. 22.6%, p = 0.027)., Conclusion: Our results suggest decreased treatment tolerance in non-cisplatin cytotoxic chemotherapy compared to cetuximab. Further prospective study is needed to clarify optimal chemotherapy in patients unable to receive cisplatin., (© 2022 S. Karger AG, Basel.)
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- 2023
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30. Perioperative Outcomes in Patients Who Underwent Fibula, Osteocutaneous Radial Forearm, and Scapula Free Flaps: A Multicenter Study.
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Bollig CA, Walia A, Pipkorn P, Jackson R, Puram SV, Rich JT, Paniello RC, Zevallos JP, Stevens MN, Wood CB, Rohde SL, Sykes KJ, Kakarala K, Bur A, Wieser ME, Galloway TLI, Tassone P, Llerena P, Bollig KJ, Mattingly TR, Pluchino T, and Jorgensen JB
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- Cohort Studies, Female, Fibula, Humans, Male, Middle Aged, Postoperative Complications epidemiology, Retrospective Studies, Treatment Outcome, Free Tissue Flaps, Head and Neck Neoplasms surgery, Plastic Surgery Procedures
- Abstract
Importance: Studies comparing perioperative outcomes of fibula free flaps (FFFs), osteocutaneous radial forearm free flaps (OCRFFFs), and scapula free flaps (SFFs) have been limited by insufficient sample size., Objective: To compare the perioperative outcomes of patients who underwent FFFs, OCRFFFs, and SFFs., Design, Setting, and Participants: This cohort study assessed the outcomes of 1022 patients who underwent FFFs, OCRFFFs, or SFFs for head and neck reconstruction performed at 1 of 6 academic medical centers between January 2005 and December 2019. Data were analyzed from September 17, 2021, to June 9, 2022., Main Outcomes and Measures: Patients were stratified based on the flap performed. Evaluated perioperative outcomes included complications (overall acute wound complications, acute surgical site infection [SSI], fistula, hematoma, and flap failure), 30-day readmissions, operative time, and prolonged hospital length of stay (75th percentile, >13 days). Patients were excluded if data on flap type or clinical demographic characteristics were missing. Associations between flap type and perioperative outcomes were analyzed using logistic regression, after controlling for other clinically relevant variables. Adjusted odds ratios (aORs) with 95% CIs were generated., Results: Perioperative outcomes of 1022 patients (mean [SD] age, 60.7 [14.5] years; 676 [66.1%] men) who underwent major osseous head and neck reconstruction were analyzed; 510 FFFs (49.9%), 376 OCRFFFs (36.8%), and 136 SFFs (13.3%) were performed. Median (IQR) operative time differed among flap types (OCRFFF, 527 [467-591] minutes; FFF, 592 [507-714] minutes; SFF, 691 [610-816] minutes). When controlling for SSI, FFFs (aOR, 2.47; 95% CI, 1.36-4.51) and SFFs (aOR, 2.95; 95% CI, 1.37-6.34) were associated with a higher risk of flap loss than OCRFFFs. Compared with OCRFFFs, FFFs (aOR, 1.77; 95% CI, 1.07-2.91) were associated with a greater risk of fistula after controlling for the number of bone segments and SSI. Both FFFs (aOR, 1.77; 95% CI, 1.27-2.46) and SFFs (aOR, 1.68; 95% CI, 1.05-2.69) were associated with an increased risk of 30-day readmission compared with OCRFFFs after controlling for Charlson-Deyo comorbidity score and acute wound complications. Compared with OCRFFFs, FFFs (aOR, 1.78; 95% CI, 1.25-2.54) and SFFs (aOR, 1.96; 95% CI, 1.22-3.13) were associated with a higher risk of prolonged hospital length of stay after controlling for age and flap loss., Conclusions and Relevance: Findings of this cohort study suggest that perioperative outcomes associated with OCRFFFs compare favorably with those of FFFs and SFFs, with shorter operative times and lower rates of flap loss, 30-day readmissions, and prolonged hospital length of stay. However, patients undergoing SFFs represented a more medically and surgically complex population than those undergoing OCRFFFs or FFFs.
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- 2022
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31. Assessment of conditions leading to lost-to-follow-up of head and neck cancer patients.
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Dimon EL, Simmons JK, Ziegler A, Bollman M, Bur A, Nallani R, Smith JB, Cummings E, Fassas S, Kakarala K, Shnayder Y, and Sykes KJ
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- Follow-Up Studies, Humans, Registries, Risk Factors, Surveys and Questionnaires, Head and Neck Neoplasms surgery
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Purpose: Head and neck cancer patients require close clinical follow up to monitor and address sequelae of treatment and for adequate cancer surveillance. The goal of this study is to determine barriers and risk factors for head and neck cancer patients who are lost-to-follow-up., Materials and Methods: A chart review of the Head and Neck Cancer Registry was performed to identify patients who were lost-to-follow-up (LTF). LTF was defined as missing two consecutive appointments as recommended by their oncologic surgeon. Those identified as LTF were contacted via email and phone to complete a 16-question survey addressing possible barriers to follow up., Results: Of the 353 patients reviewed, 53 met the criteria for LTF (15%). Forty-eight participants were contacted, and 23 surveys were completed (48%). Of the 23 patients that responded, 22% reported difficulty scheduling an appointment, 30% had transportation barriers, 22% had personal or work obligations that prevented follow up, 17% did not follow up because they "felt better," and 39% were following up with an otolaryngologist or oncologist closer to home. Only three participants (13%) were aware of the recommended 5-year surveillance period., Conclusion: Head and neck cancer patients have a variety of reasons they are lost to follow-up. Understanding these barriers is critical to creating a patient-centered model that balances both clinical surveillance needs and reasonable expectations for patients. Improvements can be made to educate patients on the recommended length of follow-up and its importance., (Copyright © 2022 Elsevier Inc. All rights reserved.)
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- 2022
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32. Sarcopenia and Treatment Toxicity in Older Adults Undergoing Chemoradiation for Head and Neck Cancer: Identifying Factors to Predict Frailty.
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Morse RT, Ganju RG, Gan GN, Cao Y, Neupane P, Kakarala K, Shnayder Y, and Lominska CE
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This study was performed to identify treatment related toxicities in older adults undergoing concurrent chemoradiotherapy for head and neck cancer and nutritional and skeletal muscle measures that might identify frailty. Imaging analysis was done with the following skeletal muscle measurements: skeletal muscle index (SMI), skeletal muscle density (SMD), and skeletal muscle gauge (SMG). Patients were dichotomized by age into younger (<70 years old, 221 patients) and older age groups (≥70 years old, 51 patients). Low SMI was more common in older patients (86.7%) compared to younger patients (51.7%, p < 0.01), as were low SMD (57.8% vs. 37.3%, p = 0.012) and low SMG (76.1% vs. 44.2%, p < 0.01), despite having similar BMIs (27.3 kg/m2 versus 27.7 kg/m2, p = 0.71). Older patients were significantly more likely to experience chemotherapy toxicity than younger patients (54.9% versus 32.3%, p < 0.01). On multivariate analysis age (p < 0.01), current smoking status (p < 0.01), and low SMI (p < 0.01) remained as significant predictors for missed chemotherapy cycles or discontinuation. Older patients were more likely to require ≥5-day radiation breaks than younger patients (27.5% versus 8.6%, p < 0.01). On multivariate analysis, age (p < 0.01), low albumin status (p = 0.03), and low SMI (p = 0.04) were identified as predictors of prolonged radiation treatment breaks. Based on the results of our study, sarcopenia may be used as an additional marker for frailty alongside traditional performance status scales.
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- 2022
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33. Microsurgical Management of Early Onset Alveolar Soft Part Sarcoma of the Oral Tongue: Case Report and Review of the Literature.
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Lucas JC, Karadaghy OA, Andrews B, Friedman E, Kakarala K, Przylecki W, and Arganbright J
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- Age of Onset, Humans, Infant, Male, Sarcoma, Alveolar Soft Part diagnostic imaging, Sarcoma, Alveolar Soft Part pathology, Tongue Neoplasms diagnostic imaging, Tongue Neoplasms pathology, Microsurgery, Sarcoma, Alveolar Soft Part surgery, Tongue Neoplasms surgery
- Abstract
Objectives: Alveolar soft part sarcoma is a rare subset of soft tissue sarcomas, typically presenting in subjects 15 to 35 years of age. Usual presentation sites are the trunk, extremities, and the head and neck. Subjects younger than 5 years are rarely affected., Methods: In this retrospective case report, we present a 16-month old male with a rapidly growing soft tissue mass of the anterior and posterior tongue, found to be alveolar soft part sarcoma., Results: The subject was treated with primary surgical resection and the resulting defect was reconstructed with a radial forearm free flap., Conclusions: To our knowledge, this is the youngest subject to have been diagnosed with alveolar soft part sarcoma. Surgical extirpation and microvascular reconstruction were successful, and the patient remains disease free 4 years post-operatively.
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- 2022
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34. Rates of bone reabsorption and union in mandibular reconstruction using the osteocutaneous radial forearm free flap.
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Karadaghy OA, Mussatto CC, Schatz BA, Li J, Norris TW, Nallani R, Shnayder L, Kakarala K, Tsue TT, Girod DA, Li Y, Koestler DC, Villwock MR, Harn N, and Bur AM
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- Forearm surgery, Humans, Mandible surgery, Radius surgery, Retrospective Studies, Carcinoma, Squamous Cell surgery, Free Tissue Flaps surgery, Mandibular Reconstruction, Plastic Surgery Procedures
- Abstract
Background: Historical concerns over bone resorption and malunion of the osteocutaneous radial forearm free flap (OCRFFF) limited its widespread adoption for head and neck reconstruction, despite lack of outcomes data evaluating this notion., Methods: A retrospective cohort study was performed including patients 18 years or older who underwent reconstruction of the mandible using an OCRFFF. Linear modeling and logistic regression were used to evaluate the change in bone volume and union over time., Results: One hundred and twenty-one patients were included in the study. A mixed effects linear model incorporating age, sex, treatment type, and number of bone segments did not demonstrate a significant loss of bone volume over time. A logistic regression model identified lack of adjuvant treatment and time to be significantly associated with complete union., Conclusion: This study supports that the OCRFFF is a stable form of osseus reconstruction for defects of the head and neck., (© 2021 Wiley Periodicals LLC.)
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- 2022
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35. Decision regret 3 and 6 months after treatment for head and neck cancer: Observational study of associations with clinicodemographics, anxiety, and quality of life.
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Nallani R, Smith JB, Penn JP, Bur AM, Kakarala K, Shnayder Y, Villwock MR, and Sykes KJ
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- Anxiety etiology, Decision Making, Emotions, Humans, Retrospective Studies, Surveys and Questionnaires, Head and Neck Neoplasms therapy, Quality of Life
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Background: While quality of life (QOL), psychosocial health, and adverse treatment outcomes have been studied in head and neck cancer (HNC) patients, decision regret is an important and understudied complication that can negatively impact future health care decision making., Methods: Data collected using a HNC patient registry with questionnaires administered at initial consultation visits plus 3 and 6 months after treatment completion was retrospectively analyzed. A visual analog anxiety scale and the University of Washington Quality of Life were given at clinic visits. Decision regret was determined using a validated scale. Demographic and clinical variables were collected retrospectively and at baseline., Results: Patients with higher anxiety and lower self-reported QOL had higher concurrent regret at 3-month (n = 140) and at 6-month (n = 82) post-treatment. Later disease stage at presentation, nonprimary surgical treatment, and lower health literacy were associated with greater regret., Conclusions: Decision regret was highest in HNC patients with high anxiety, low QOL, and more advanced disease., (© 2021 Wiley Periodicals LLC.)
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- 2022
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36. Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis.
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Josyabhatla R, Kamdar AA, Armbrister SA, Daniel R, Boukas K, Smith KG, Van Arsdall MR, Kakarala K, Flores AR, Wanger A, Liu Y, and Rhoads JM
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Historically, children evaluated for vomiting and diarrhea secondary to viral enteritis have symptoms lasting 2-4 days and respond to supportive care, including oral rehydration and anti-emetics if required. Recently, within a 14-day timespan, we encountered three children with severe diarrhea who rapidly became dehydrated and went into hypotensive shock. Although SARS-CoV-2 molecular tests were negative by nasopharyngeal swab, all were later found to have MIS-C. This small case series underscores features reported in previous larger studies and emphasizes the rapid clinical evolution of this condition. We highlight the importance of early recognition of cardinal laboratory findings characteristic of MIS-C (i.e., lymphopenia, markedly elevated acute phase reactants, and hypoalbuminemia). We also show serologic evidence that the pathophysiological mechanism of SARS-CoV-2 related diarrhea may differ from other causes of dehydrating vomiting and diarrhea, with no serologic evidence of villus cell injury., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Josyabhatla, Kamdar, Armbrister, Daniel, Boukas, Smith, Van Arsdall, Kakarala, Flores, Wanger, Liu and Rhoads.)
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- 2021
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37. Assessing American Head and Neck Society members' views of potential conflicts of interest among researchers and society leaders.
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Jorgensen JB, Kakarala K, Bollig C, Elkins C, and Campbell BH
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- Head, Humans, United States, Conflict of Interest, Neck
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- 2021
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38. Telemedicine for head and neck cancer surveillance in the COVID-19 era: Promise and pitfalls.
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Fassas S, Cummings E, Sykes KJ, Bur AM, Shnayder Y, and Kakarala K
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- Humans, Retrospective Studies, SARS-CoV-2, COVID-19, Head and Neck Neoplasms therapy, Telemedicine
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Background: The coronavirus disease 2019 pandemic has led to increased telemedicine visits. This study examines current preferences and barriers for telemedicine among patients with head and neck cancer., Methods: Single institution retrospective analysis of 64 patients scheduling visits with the head and neck surgical oncology clinic at a tertiary academic medical center. Data were collected detailing patient preferences and barriers regarding telemedicine appointments. Patients electing to participate in telemedicine were compared to those preferring in-person appointments., Results: Most patients (68%) were not interested in telemedicine. Preference for in-person examination was the most common reason for rejecting telemedicine, followed by discomfort with or limited access to technology. Patients elected telemedicine visits to avoid infection and for convenience., Conclusions: When given a choice, patients with head and neck cancer preferred in-person visits over telemedicine. Although telemedicine may improve health care access, patient preferences, technology-related barriers, and limitations regarding cancer surveillance must be addressed moving forward., (© 2021 Wiley Periodicals LLC.)
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- 2021
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39. Risk Factors for Post-acute care Following Free Flap Reconstruction of the Oral Cavity.
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Lepse J, Sykes KJ, and Kakarala K
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- Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Free Tissue Flaps, Mouth Neoplasms surgery, Postoperative Complications epidemiology, Postoperative Complications therapy, Plastic Surgery Procedures methods, Subacute Care statistics & numerical data
- Abstract
Objective: Identify previously unreported factors that predict the need for post-acute care after free flap reconstruction of the oral cavity., Study Design: Retrospective cohort study., Setting: Single academic medical center., Methods: A total of 134 patients with head and neck disease involving the oral cavity underwent free tissue transfer for reconstruction between August 2012 and October 2015. All patients had a tracheostomy placed at the time of surgery. Data were collected, including demographics, perioperative risk factors, and social variables. Univariate and multivariate logistic regression were used to identify risk factors for needing post-acute care., Results: Of 134 patients, 37 (28%) required post-acute care upon discharge, and 97 of 134 (72%) were discharged home with assistance. Multivariate logistic regression revealed that lack of family support (adjusted odds ratio [AOR], 32.12; 95% CI, 13.75-274.90; P = .002), tracheostomy tube at discharge (AOR, 13.70; 95% CI, 3.20-58.44; P < .001), government insurance (AOR, 3.85; 95% CI, 1.13-13.11; P = .031), hospital stay >10 days (AOR, 3.52; 95% CI, 1.25-9.90; P = .017), and increasing age (AOR, 1.11; 95% CI, 1.04-1.18; P = .003) were significantly associated with post-acute care need., Conclusion: Lack of family support, tracheostomy tube at discharge, government insurance, hospital stay >10 days, and increasing age are independently associated with the need for post-acute care following free flap reconstruction of the oral cavity. Physicians, social workers, and nurse case managers are positioned to identify patients at high risk for needing post-acute care and to reduce the duration of hospitalizations.
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- 2021
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40. Management of Advanced Basal Cell Carcinoma of the Head and Neck.
- Author
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Monroe M and Kakarala K
- Subjects
- Combined Modality Therapy, Humans, Carcinoma, Basal Cell surgery, Head and Neck Neoplasms surgery, Skin Neoplasms
- Abstract
Basal cell carcinoma is the most common human malignancy, with an incidence exceeding all other cancers combined. Advanced basal cell cancer requires a multidisciplinary approach to management. The mainstay of treatment remains surgical excision with appropriate reconstruction. Some advanced tumors may require radical resections; however, extensive, high-risk surgery may be justified by the indolent biology of the disease and the likelihood of cure. Other options, such as radiation or systemic targeted therapy, may be considered in selected patients who either refuse or are not candidates for surgery. The focus of this article is primarily on management of these high-risk cases., Competing Interests: Disclosure M. Monroe has served on cutaneous squamous cell carcinoma advisory boards for Merck, Sanofi-Adventis, and Regeneron. He has research funding from the NIH (NIDCR), American Head and Neck Society, and Huntsman Cancer Institute. K. Kakarala has no disclosures., (Published by Elsevier Inc.)
- Published
- 2021
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41. Descriptions and outcomes of cardiac evaluations in pediatric patients hospitalized for asthma.
- Author
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Parlar-Chun R, Kakarala K, and Singh M
- Subjects
- Adolescent, Asthma blood, Asthma therapy, Child, Child, Preschool, Echocardiography economics, Electrocardiography economics, Female, Heart Diseases blood, Heart Diseases epidemiology, Heart Diseases etiology, Hospitalization economics, Hospitalization statistics & numerical data, Humans, Male, Predictive Value of Tests, Retrospective Studies, Symptom Flare Up, Tertiary Care Centers economics, Tertiary Care Centers statistics & numerical data, Troponin I blood, Troponin T blood, Asthma complications, Echocardiography statistics & numerical data, Electrocardiography statistics & numerical data, Heart Diseases diagnosis
- Abstract
Objective: Patients hospitalized for asthma can exhibit concurrent cardiac symptoms and undergo cardiac work up. We identify patients admitted for asthma that underwent cardiac workup and describe outcomes to evaluate the utility of cardiac testing in this population. Methods: Patients aged 4 to 17 years admitted for status asthmaticus from 2012 - 2016 were screened for EKG, ECHO, or cardiac enzyme obtainment. Results: Out of 1296 patients, 77 (6%) received cardiac testing. The most common reasons for testing were chest pain (25, 32%), blood pressure abnormalities (11, 14%), tachycardia (8, 10%), arrhythmia (6, 8%), and syncope (6, 8%). Sinus tachycardia (43, 66%) was the most common EKG finding. 4 out of 27 patients who underwent ECHOs had abnormalities: 2 with hypertrophic cardiomyopathy (HCM), 1 with vascular ring, and 1 with evidence of pulmonary hypertension. All patients who underwent an EKG to evaluate tachycardia had normalization of heart rate at discharge. Cardiac ischemia was not evident in any patients who underwent workup with cardiac enzymes to evaluate chest pain. All cases of arrhythmias resolved on discharge. Diastolic hypotension (DhTN) was found in 10 out of the 11 blood pressure abnormalities. There was mixed efficacy of fluid bolus in correcting DhTN. All DhTN resolved on discharge. One patient with syncope had a new diagnosis of HCM. Conclusions: While cardiac complications are seen in patients admitted for status asthmaticus, the etiology rarely stems from underlying cardiac disease. EKGs, ECHOs, and cardiac enzymes should have a minimal role in the management of the hospitalized asthmatic patient.
- Published
- 2020
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42. Pathology protocol increases lymph node yield in neck dissection for oral cavity squamous cell carcinoma.
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Holcomb AJ, Perryman M, Goodwin S, Penn J, Villwock MR, Bur AM, Shnayder Y, Tsue TT, Woodroof J, and Kakarala K
- Subjects
- Humans, Lymph Nodes pathology, Lymph Nodes surgery, Neoplasm Staging, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms pathology, Mouth Neoplasms surgery, Neck Dissection
- Abstract
Background: Lymph node yield (LNY) is a proposed quality indicator in neck dissection for oral cavity squamous cell carcinoma (OCSCC)., Methods: Retrospective series including 190 patients with OCSCC undergoing neck dissection between 2016 and 2018. A change in pathologic grossing protocol was initiated during the study period to assess residual adipose tissue. A generalized linear model was used to assess the impact of multiple variables on LNY., Results: Mean LNY was 28.59 (SD = 17.65). The protocol identified a mean of 10.32 lymph nodes per case. Multivariable analysis identified associations between LNY and use of the pathology protocol (P = .02), number of dissected lymph node levels (P < .001), presence of pathologic lymph nodes (P = .002), body mass index (P = .02), prior neck surgery (P = .001), and prior neck radiation (P = .001)., Conclusions: Assessment of residual adipose tissue within neck dissection specimens improves accuracy of LNY. LNY in neck dissection is influenced by multiple factors including methods of pathologic assessment., (© 2020 Wiley Periodicals LLC.)
- Published
- 2020
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43. What is the hold up?-Mixed-methods analysis of postoperative radiotherapy delay in head and neck cancer.
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Sykes KJ, Morrow E, Smith JB, Holcomb AJ, TenNapel M, Lominska CE, Bur AM, and Kakarala K
- Subjects
- Humans, Neoplasm Recurrence, Local, Radiotherapy, Adjuvant, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms surgery, Radiation Oncology
- Abstract
Background: Delays in postoperative radiotherapy (PORT) for head and neck cancer (HNC) increase the risk for recurrence and mortality. The multifactorial nature of delays calls for an in-depth understanding of potential contributors from the patient's and provider's perspectives. We sought to identify causes of delays in adjuvant radiotherapy initiation for HNC., Methods: We performed a mixed-methods study including patients with HNC care team members. Forty in-depth interviews were performed (26 patients; 14 care team members). Timing and demographic data were collected from medical records., Results: Median time from surgery to radiotherapy initiation was 45 days; 15 participants began after 42 days. Process delays and failure to communicate the urgency and significance of PORT initiation contributes to delays. Patients with a strong social support system experience less delays., Conclusions: Achieving reductions in PORT initiation requires efficient care coordination, improved communication between interdisciplinary teams, and strengthening social support systems for patients with HNC., (© 2020 Wiley Periodicals LLC.)
- Published
- 2020
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44. Lateral thoracic artery as recipient vessel for head and neck free flap reconstruction in the vessel depleted neck: A case report.
- Author
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Ibrahim ASG, Kakarala K, and Bur AM
- Subjects
- Humans, Male, Middle Aged, Free Tissue Flaps blood supply, Mandibular Diseases surgery, Mandibular Osteotomy, Neck blood supply, Osteoradionecrosis surgery, Plastic Surgery Procedures methods, Thoracic Arteries surgery
- Abstract
Vessel depleted necks present a challenge to identifying suitable recipient vessels for microvascular head and neck reconstruction. Many alternative recipient vessels have been described. The purpose of this report is to describe the feasibility of using the lateral thoracic artery as a recipient vessel for head and neck free flap reconstruction in vessel depleted necks. In this report we describe surgery for a 62 year old male with osteoradionecrosis of the right mandibular body in which we performed right segmental mandibulectomy with free fibular flap reconstruction in a vessel depleted neck. We used the lateral thoracic artery which was ~10 cm in length. It provided good reach to the neck, proper blood flow, and acceptable vessel diameter of ~1.5 mm at 6 cm above the clavicle. The patient had an uncomplicated postoperative course and the flap was viable and well healed at 2 months follow-up. The lateral thoracic artery could be considered as one of the options for recipient vessels for microvascular reconstruction in patients with vessel depleted necks., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
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45. Rhabdomyolysis in a Morbidly Obese Patient After Oral Cavity Free Flap Reconstruction.
- Author
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Wichova H, Subbarayan R, Muelleman T, and Kakarala K
- Abstract
Post-operative rhabdomyolysis is a rare but life-threatening condition. Less than ten cases have been described in the otolaryngic literature and, to our knowledge, no reports exist in the setting of oral reconstructive free tissue transfer. Case report presentation. We discuss the clinical course that lead to the diagnosis of rhabdomyolysis with special consideration to simultaneous microvascular anastomosis. Serial lab values were closely followed to prevent kidney injury while preventing flap congestion. Excessive fluid resuscitation in free flap reconstruction has been associated with increased post-operative complications and flap failure. We present a cautionary case to highlight the need for early diagnosis of rhabdomyolysis, a condition that may become more prevalent in the head and neck population as obesity, the main risk factor, continues to increase worldwide., Competing Interests: Conflict of interestAll authors declare that they have no conflict of interest., (© Association of Otolaryngologists of India 2018.)
- Published
- 2019
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46. Association of a Lean Surgical Plan of the Day With Reduced Operating Room Time for Head and Neck Free Flap Reconstruction.
- Author
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Ibrahim A, Ndeti K, Bur A, Sykes K, Shnayder L, Tsue T, Westbrook A, and Kakarala K
- Abstract
Importance: Inefficiency in the operating room (OR) is detrimental to the patient, the hospital, and the surgeon. Head and neck procedures requiring microvascular reconstruction are complex, lengthy operations in which prolonged operative time is associated with higher complication rates and increased costs., Objective: To use Lean methodology to identify potential OR efficiency improvement opportunities for head and neck surgical cases involving free tissue transfer, to implement an intervention, the free flap plan of the day, and to evaluate OR times after implementation., Design, Setting, and Participants: Phase 1: In 2015, with the assistance of the Lean Promotion Office at our institution, a tertiary academic medical center, we identified efficiency-improvement opportunities for 10 patients undergoing free flap reconstruction. Phase 2: A single intervention, the free flap plan of the day, was implemented on February 1, 2016. A retrospective medical record review of head and neck free flap reconstructions beginning 2 years before the implementation of the intervention and ending 2 years after the intervention was performed from February 1, 2014 until February 1, 2018 to analyze OR times, cost, and complications. Mean OR times were compared using the t test., Main Outcomes and Measures: In-room-to-incision time and total OR time., Results: Phase 1: The surgical procedures of 10 patients undergoing free flap reconstruction were observed by Lean specialists, and a time study with a process map was completed. Using this framework, major opportunities for decreasing intraoperative time waste were identified. Multiple communication breakdowns were seen to drive intraoperative time waste; therefore, a free flap plan of the day was created to improve communication between team members. Phase 2: 200 patients were included in the study and were categorized into 2 groups, no plan group (n = 104) and plan group (n = 96), based on whether the plan of the day was used or not. The age and sex distributions of the study participants were not collected. Mean in-room-to-incision time was 54.3 minutes for the no plan group and 47.2 minutes for the plan group (difference, 7.1 minutes; 95% CI, 3.8-10.4 minutes). Mean total OR time was 524.1 minutes for the no plan group and 467.4 minutes for the plan group (difference, 56.7 minutes; 95% CI, 23.6-89.6 minutes)., Conclusions and Relevance: Lean methodology was used to identify efficiency-improvement opportunities for head and neck free flap reconstruction procedures and to design a focused intervention. A free flap plan of the day was used in this study to improve communication between the OR team and was found to improve efficiency and be associated with reduced OR times.
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- 2019
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47. Weekly cisplatin chemotherapy dosing versus triweekly chemotherapy with concurrent radiation for head and neck squamous cell carcinoma.
- Author
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Morse RT, Ganju RG, TenNapel MJ, Neupane P, Kakarala K, Shnayder Y, Chen AM, and Lominska CE
- Subjects
- Aged, Antineoplastic Agents administration & dosage, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Progression-Free Survival, Radiotherapy, Intensity-Modulated, Retrospective Studies, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell therapy, Chemoradiotherapy, Cisplatin administration & dosage, Head and Neck Neoplasms mortality, Head and Neck Neoplasms therapy
- Abstract
Background: Triweekly high-dose cisplatin (100 mg/m
2 ) with concurrent radiation therapy is the current standard of care in the definitive or appropriate postoperative setting in head and neck squamous cell carcinoma (HNSCC). We compared triweekly 100 mg/m2 with alternative weekly 40 mg/m2 and weekly <40 mg/m2 cisplatin regimens., Methods: From 2011 to 2016, 163 patients received concurrent cisplatin and intensity-modulated radiotherapy for locally advanced HNSCC. Primary endpoints were overall survival (OS) and progression-free survival., Results: Cisplatin weekly <40 mg/m2 showed inferior OS outcomes when compared to weekly 40 mg/m2 (P = 0.084) and triweekly 100 mg/m2 (P = 0.04) regimens., Conclusion: Our study displayed inferior outcomes with weekly cisplatin doses under 40 mg/m2 , suggesting the inferiority of low-dose weekly chemotherapy and the need for ongoing randomized trials to further explore 40 vs 100 mg/m2 chemotherapy regimens., (© 2019 Wiley Periodicals, Inc.)- Published
- 2019
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48. Machine learning to predict occult nodal metastasis in early oral squamous cell carcinoma.
- Author
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Bur AM, Holcomb A, Goodwin S, Woodroof J, Karadaghy O, Shnayder Y, Kakarala K, Brant J, and Shew M
- Subjects
- Aged, Algorithms, Artificial Intelligence, Databases, Factual, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Models, Theoretical, Neoplasm Grading, Prognosis, ROC Curve, Sensitivity and Specificity, Carcinoma, Squamous Cell diagnosis, Machine Learning, Mouth Neoplasms diagnosis
- Abstract
Objectives: To develop and validate an algorithm to predict occult nodal metastasis in clinically node negative oral cavity squamous cell carcinoma (OCSCC) using machine learning. To compare algorithm performance to a model based on tumor depth of invasion (DOI)., Materials and Methods: Patients who underwent primary tumor extirpation and elective neck dissection from 2007 to 2013 for clinical T1-2N0 OCSCC were identified from the National Cancer Database (NCDB). Multiple machine learning algorithms were developed to predict pathologic nodal metastasis using clinicopathologic data from 782 patients.The algorithm was internally validated using test data from 654 patients in NCDB and was then externally validated using data from 71 patients treated at a single academic institution. Performance was measured using area under the receiver operating characteristic (ROC) curve (AUC). Machine learning and DOI model performance were compared using Delong's test for two correlated ROC curves., Results: The best classification performance was achieved with a decision forest algorithm (AUC = 0.840). When applied to the single-institution data, the predictive performance of machine learning exceeded that of the DOI model (AUC = 0.657, p = 0.007). Compared to the DOI model, machine learning reduced the number of neck dissections recommended while simultaneously improving sensitivity and specificity., Conclusion: Machine learning improves prediction of pathologic nodal metastasis in patients with clinical T1-2N0 OCSCC compared to methods based on DOI. Improved predictive algorithms are needed to ensure that patients with occult nodal disease are adequately treated while avoiding the cost and morbidity of neck dissection in patients without pathologic nodal disease., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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49. Comparison of Modern Rigid Fixation Plating Outcomes for Segmental Mandibular Microvascular Reconstruction.
- Author
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McCann AC, Shnayder Y, Przylecki WH, Kakarala K, Nazir N, Girod DA, and Andrews BT
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Vascular Surgical Procedures methods, Young Adult, Bone Plates, Computer-Aided Design, Mandibular Reconstruction methods, Microvessels surgery
- Abstract
Objectives/hypothesis: New advances in osseous microvascular mandibular rigid fixation are being employed at many institutions. These include standardized prebent/preformed reconstruction plates as well as computer-aided design/computer-aided manufacturing (CAD/CAM) custom plates that are patient specific. Our goal was to assess and compare the outcomes of both of these new technologies when utilized for mandibular microvascular reconstruction., Study Design: Retrospective chart review., Methods: Subjects were categorized into two groups according to their mandibular rigid fixation technique: group 1 = prebent/preformed plates and group 2 = CAD/CAM custom plates. Primary outcome measures were 1) perioperative complications (defined as deep tissue infection, wound dehiscence resulting in bone exposure, and/or plate exposure) and 2) reoperation rates for mandibular hardware failure/explantation. Statistical analysis consisted of χ
2 , Fisher exact test, and multivariable regression models., Results: A total of 142 subjects underwent microvascular mandibular reconstruction in a 6-year period. Eighty-nine subjects utilized prebent/preformed plates, and 53 employed CAD/CAM custom plates. Perioperative complications occurred in 32 of 89 (35.9%) subjects with prebent/preformed plates and 11 of 53 (20.7%) subjects using CAD/CAM custom plates. Reoperation requiring hardware explantation occurred in 18 of 89 (20.2%) subjects and three of 53 (5.6%) using CAD/CAM custom plates. Statistical comparison of perioperative complications between the two groups approached significance (P = .0556), and the rate of reoperation was significant favoring CAD/CAM implants (P = .0180)., Conclusions: In our experience, CAD/CAM custom plates utilized for rigid fixation during microvascular mandibular reconstruction demonstrated fewer complications and statistically lower reoperation rates when compared with prebent/preformed plates., Level of Evidence: 2c Laryngoscope, 129:1081-1086, 2019., (© 2018 The American Laryngological, Rhinological and Otological Society, Inc.)- Published
- 2019
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50. Atypical Form of Cervicofacial Actinomycosis Involving the Skull Base and Temporal Bone.
- Author
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McCann A, Alvi SA, Newman J, Kakarala K, Staecker H, Chiu A, and Villwock JA
- Subjects
- Actinomycosis, Cervicofacial drug therapy, Actinomycosis, Cervicofacial surgery, Administration, Intravenous, Administration, Oral, Aged, Anti-Bacterial Agents therapeutic use, Combined Modality Therapy, Debridement, Disease Progression, Humans, Male, Mastoidectomy, Maxilla surgery, Osteomyelitis drug therapy, Osteomyelitis surgery, Pterygopalatine Fossa surgery, Treatment Outcome, Actinomycosis, Cervicofacial microbiology, Mastoid microbiology, Osteomyelitis microbiology, Skull Base microbiology
- Abstract
Background:: Cervicofacial actinomycosis is an uncommon indolent infection caused by Actinomyces spp that typically affects individuals with innate or adaptive immunodeficiencies. Soft tissues of the face and neck are most commonly involved. Actinomyces osteomyelitis is uncommon; involvement of the skull base and temporal bone is exceedingly rare. The authors present a unique case of refractory cervicofacial actinomycosis with development of skull base and temporal bone osteomyelitis in an otherwise healthy individual., Methods:: Case report with literature review., Results:: A 69-year-old man presented with a soft tissue infection, culture positive for Actinomyces, over the right maxilla. Previous unsuccessful treatment included local debridement and 6 weeks of intravenous ceftriaxone. He was subsequently treated with conservative debridement and a prolonged course of intravenous followed by oral antibiotic. However, he eventually required multiple procedures, including maxillectomy, pterygopalatine fossa debridement, and a radical mastoidectomy to clear his disease. Postoperatively he was gradually transitioned off intravenous antibiotics., Conclusions:: Cervicofacial actinomycosis involves soft tissue surrounding the facial skeleton and oral cavity and is typically associated with a history of mucosal trauma, surgery, or immunodeficiency. The patient was appropriately treated but experienced disease progression and escalation of therapy. Although actinomycosis is typically not an aggressive bacterial infection, this case illustrates the need for prompt recognition of persistent disease and earlier surgical intervention in cases of recalcitrant cervicofacial actinomycosis. Chronic actinomycosis has the potential for significant morbidity.
- Published
- 2019
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