Search

Your search keyword '"Kakade, Mahadeo"' showing total 18 results
Start Over Author "Kakade, Mahadeo"
18 results on '"Kakade, Mahadeo"'

6. Understanding the resurgence of chikungunya virus during 2020−2021 in Pune, India, based on genomic analyses: A seven year study

Author

Alagarasu, Kalichamy, primary, Patil, Jayashri, additional, Jadhav, Santoshkumar, additional, Chowdhury, Deepika, additional, Bote, Minal, additional, Punekar, Madhura, additional, More, Ashwini, additional, Kakade, Mahadeo, additional, Bachal, Rupali, additional, Gurav, Yogesh, additional, Cherian, Sarah, additional, and Parashar, Deepti, additional

Published
2023
Full Text
View/download PDF

12. First case of Zika virus infection during an outbreak of chikungunya in a rural region of Maharashtra state, India

Author

Gurav, Yogesh K, primary, Alagarasu, Kalichamy, additional, Yadav, Pragya D, additional, Sapkal, Gajanan, additional, Gokhale, Mangesh, additional, Parashar, Deepti, additional, Jadhav, Ujwala, additional, Bote, Minal, additional, Kakade, Mahadeo, additional, Nyayanit, Dimpal, additional, Kumar, Abhinendra, additional, Deshpande, Gururaj Rao, additional, Cherian, Sarah, additional, Awate, Pradip S, additional, and Abraham, Priya, additional

Published
2022
Full Text
View/download PDF

14. TNFA and IL10 Polymorphisms and IL-6 and IL-10 Levels Influence Disease Severity in Influenza A(H1N1)pdm09 Virus Infected Patients

Author

Alagarasu, Kalichamy, primary, Kaushal, Himanshu, additional, Shinde, Pooja, additional, Kakade, Mahadeo, additional, Chaudhary, Urmila, additional, Padbidri, Vikram, additional, Sangle, Shashikala A., additional, Salvi, Sonali, additional, Bavdekar, Ashish R., additional, D’costa, Pradeep, additional, and Choudhary, Manohar Lal, additional

Published
2021
Full Text
View/download PDF

15. Detection of dengue-4 virus in pune, western india after an absence of 30 years - its association with two severe cases

Author

Patil Jayashri A, Singh Anand, Vallentyne Joyprashant, Bhagat Asha B, Kakade Mahadeo B, Cecilia Dayaraj, Todkar Shankar M, Varghese Sunitha B, and Shah Paresh S

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Difference in severity of dengue outbreaks has been related to virus serotype, genotype and clades within genotypes. Till the 1980 s, India and Sri Lanka reported low number of dengue hemorrhagic fever (DHF) cases despite circulation of all four serotypes of dengue virus (DENV). Since the 1990 s the occurrence of DHF has increased. The increase has been attributed to changes in virus lineage especially with regard to DENV-2 and DENV-3. DENV-1 has been associated with dengue fever (DF) outbreaks and DENV-4 reports have been rare. The emergence of DENV-4 was reported recently in 2003 in Delhi and in 2007 in Hyderabad. The last report of DENV-4 from Maharashtra was in 1975 from Amalner. Results We report on the detection of DENV-4 in Pune, Maharashtra after an absence of almost 30 years. Two cases were detected in 2009-10, serotyped by multiplex reverse transcriptase polymerase chain reaction (RT-PCR). Both the cases were recorded as severe dengue (Category 3) requiring intensive care unit (ICU) level of treatment. Depending on the hemagglutination inhibiting (HI) antibody titres the 2009 case was characterized as a primary infection and the 2010 case as a secondary infection. Both the cases presented plasma leakage and neither showed any kind of haemorrhage. The 2009 case survived while the 2010 case was fatal. An isolate was obtained from the 2009 case. Based on envelope (E) gene sequence analysis, the virus belonged to genotype I of DENV-4, and clustered with isolates from India and Sri Lanka and was distant from the isolates from Thailand. The nucleotide and amino acid diversity of the E gene of the Indian isolates increased from 1996 to 2007 to 2009 in context of the E gene sequences of other isolates belonging to genotype I. Conclusion The increasing diversity in the circulating DENV-4 calls for close monitoring of the DENV-4 serotype.

Published
2011
Full Text
View/download PDF

16. Predictors of Dengue-Related Mortality and Disease Severity in a Tertiary Care Center in North India

Author

Jain, Siddharth, Mittal, Abhenil, Sharma, Surendra Kumar, Upadhyay, Ashish Datt, Pandey, Ravindra Mohan, Sinha, Sanjeev, Soneja, Manish, Biswas, Ashutosh, Jadon, Ranveer Singh, Kakade, Mahadeo B., and Dayaraj, Cecilia

Subjects
severity, predictors, outbreak, Major Article, dengue shock, mortality
Abstract

Background. There is lack of reliable predictors of disease severity and mortality in dengue. The present study was carried out to identify these predictors during the 2015 outbreak in India. Methods. This prospective observational study included confirmed adult dengue patients hospitalized between August and November 2015 in a tertiary care centre in New Delhi, India. Appropriate statistical tests were used to compare clinicolaboratory characteristics, derive predictors of severe disease and mortality, and compute a predictive score for mortality. Serotyping was done. Results. Data of 369 patients were analyzed (mean age, 30.9 years; 67% males). Of these, 198 (54%) patients had dengue fever, 125 (34%) had dengue hemorrhagic fever (grade 1 or 2), and 46 (12%) developed dengue shock syndrome (DSS). Twenty-two (6%) patients died. Late presentation to the hospital (≥5 days after onset) and dyspnea at rest were identified as independent predictors of severe disease. Age ≥24 years, dyspnea at rest and altered sensorium were identified as independent predictors of mortality. A clinical risk score was developed (12*age + 14*sensorium + 10*dyspnea), which, if ≥22, predicted mortality with a high sensitivity (81.8%) and specificity (79.2%). The predominant serotypes in Delhi (2015) were dengue virus DENV2 and DENV4. Conclusion. Age ≥24 years, dyspnea at rest, and altered sensorium were identified as independent predictors of mortality. Platelet counts did not determine outcome in dengue patients. Timely referral/access to healthcare is important. The clinical risk score for mortality prediction that was developed in this study can be used in all healthcare settings, after validation in larger cohorts.

Published
2017

18. Understanding the resurgence of chikungunya virus during 2020-2021 in Pune, India, based on genomic analyses: A seven year study.

Author

Alagarasu K, Patil J, Jadhav S, Chowdhury D, Bote M, Punekar M, More A, Kakade M, Bachal R, Gurav Y, Cherian S, and Parashar D

Subjects
Humans, Phylogeny, India epidemiology, Disease Outbreaks, Genomics, Chikungunya virus genetics, Chikungunya Fever epidemiology
Abstract

A surge in chikungunya was observed during 2020-21 in Pune district of Maharashtra, India. Whole genome sequencing and phylogenetic analysis of 21 samples/sequences revealed them as Indian ocean lineage of East Central South African genotype. Two distinct sequence clusters were found to circulate during 2020-21; one with E1:K211E and E2:V264A mutations while the other had E1:I317V mutation along with E1:K211E and E2: V264A mutations. The former, the predominant cluster (n = 18), clustered with chikungunya virus (CHIKV) strains of pre 2014 period while the latter (n = 3) clustered with 2016-2018 period Indian strains. Though E1: A226V was not detected in any of the 21 sequences, several unique mutations were detected in the strains which might have played key roles in the enhanced virus transmission during the period. The study highlights parallel evolution, introduction from the neighboring regions and cocirculation of two sequence clusters of CHIKV in Pune. The complete genome data can be useful to determine how the circulating strains differ from candidate vaccines and might help to predict the protective efficacy of chikungunya vaccine candidates., (© 2023 Wiley Periodicals LLC.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results