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4. Abstracts Of Selected Papers Presented At The 75Th General Meeting Of The Japanese Society Of Gastroenterology March 27–29, 1989 — Yokohama, Japan

Author

Tanabe, Satoshi, Saigenji, Katsunori, Asaki, Shigeru, Sato, Akira, Takeda, Isao, Nakano, Satoshi, Inoue, Yoshihiro, Kano, Atsushi, Shiina, Yasubumi, Miwa, Takeshi, Takahashi, Hiroshi, Namatame, Kimio, Sugawa, C., Nakamura, R., Uchida, Hideichi, Kodama, Tadashi, Oka, Shinji, Okazaki, Yukinori, Sato, Nobuhiro, Ogihara, Tatsuo, Niwa, Yasumasa, Nakazawa, Saburo, Azuumi, Yoshiteru, Saigenji, Katsunori, Saito, Yutaka, Sato, Kunio, Iwasaki, Ariyoshi, Abe, Masanao, Miyairi, Mamoru, Suyama, Kyoichiro, Hayakawa, Tetsuo, Suzuki, Toshiyuki, Miyake, Hirofumi, Ochi, Koji, Wakasugi, Hideyuki, Funakoshi, Akihiro, Nakano, Satoshi, Sugiyama, Keiichi, Manabe, Tadao, Baba, Nobuo, Yamamoto, Masahiro, Saitoh, Yoichi, Tamura, Kazutami, Fukuda, Yoshihiro, Sakaki, Nobuhiro, Ietomi, Katsuyuki, Yamada, Masahiro, Ohkusa, Toshifumi, Takahashi, Shinichi, Saito, Shozo, Satoh, Kiichi, Kimura, Ken, Ito, Shigeji, Kohli, Yoshihiro, Koyama, S., Bamba, T., Takagi, A., Kojima, K., Sugiyama, T., Yabana, T., Tada, Masahiro, Shigeeda, Masaki, Yoshida, M., Imoto, I., Hashiguchi, Takafumi, Shibue, Tadashi, Saita, Hiroshi, Murakami, Motonobu, Tsujii, Masahiko, Kawano, Sunao, Shirai, Takayuki, Harasawa, Shigeru, Yamamoto, Tomikazu, Nishio, Akiyoshi, Saeki, Susumu, Oh, Toumei, Tatsuta, Masaharu, Ishii, Hiroyasu, Nishiwaki, Hideki, Satake, Katsusuke, Matsuzaki, Yasushi, Tanaka, Naomi, Knakano, Akira, Fukushima, Tsuneo, Horiuchi, I., Kajiyama, G., Saito, Hideaki, Morioka, Yasuhiko, Miura, Soichiro, Yoshioka, Masahiro, and Takahashi, Naomi

Published
1991
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19. Expression of interleukin-8 correlates with vascularity in human gastric carcinomas

Author

Kitadai, Y., Haruma, K., Sumii, K., Yamamoto, S., Ue, T., Hiroshi Yokozaki, Yasui, W., Ohmoto, Y., Kajiyama, G., Fidler, I. J., and Tahara, E.

Subjects
Adult, Male, Epidermal Growth Factor, Carcinoma, Interleukin-8, Middle Aged, Transforming Growth Factor alpha, Stomach Neoplasms, Tumor Cells, Cultured, Blood Vessels, Humans, Female, Tissue Distribution, RNA, Messenger, Cell Division, Research Article, Aged, Interleukin-1
Abstract

Interleukin (IL)-8 is a multifunctional cytokine that can stimulate the division of endothelial cells. We examined the expression of IL-8 mRNA using Northern blot analysis and in situ mRNA hybridization (ISH) and protein production using enzyme-linked immunosorbent assay and immunohistochemistry in 8 human gastric carcinoma cell lines and 39 gastric carcinomas and corresponding normal mucosa (34 surgical specimens and 5 biopsy specimens). Of the 8 human gastric carcinoma cell lines, 6 expressed 1.8-kb IL-8 mRNA and secreted various levels of IL-8 protein. The expression of IL-8 by TMK-1 cells was induced by exposure to IL-1 alpha, epidermal growth factor, and transforming growth factor-alpha, shown previously to be autocrine growth stimulators for human gastric carcinoma cells. In tumor tissues, most of the tumors (28 of 34 surgical specimens and 4 of 5 biopsy specimens) expressed IL-8 at higher levels than the corresponding normal mucosa. ISH and immunohistochemical analyses revealed that IL-8 mRNA and protein were localized in the cytoplasm of tumor cells. The number of blood vessels in the gastric carcinomas was determined by using antibodies against CD34. The level of IL-8 mRNA in the neoplasms strongly correlated with vascularization (Spearman correlation, r = 0.812; P = 0.001). The data suggest that IL-8 produced by tumor cells may regulate neovascularization and, hence, the growth and spread of human gastric carcinoma.

Published
1998

25. Immunoreactive transforming growth factor alpha is commonly present in colorectal neoplasia

Author

Tanaka, S., Imanishi, K., Yoshihara, M., Haruma, K., Sumii, K., Kajiyama, G., and Akamatsu, S.

Subjects
Antibody Specificity, Reference Values, Humans, Cross Reactions, Intestinal Mucosa, Transforming Growth Factor alpha, Colorectal Neoplasms, Immunohistochemistry, Antibodies, Research Article
Abstract

Surgical specimens from 19 patients with invasive colorectal cancers and 12 specimens of normal mucosa from the same patients were examined immunohistochemically for the production of the immunoreactive (IR-) transforming growth factor (TGF)-alpha and IR-epidermal growth factor (EGF) with an anti-TGF-alpha monoclonal antibody (MAb) OAL-MTG01 and anti-EGF MAb KEM-10. Immunoreactive TGF-alpha was detected in 16 (84.2%) of 19 colorectal cancers. In contrast, there was no IR-TGF-alpha in the gland cells of normal mucosa. Immunoreactive EGF was detected in 7 (36.8%) of 19 colorectal cancers and 1 (8.3%) of 12 cases of normal mucosa. The production of both IR-TGF-alpha and IR-EGF in colorectal cancer did not differ by histologic type and Dukes' stage. Immunoreactive TGF-alpha was detected at significantly higher incidence than IR-EGF in colorectal cancer. These results indicate that IR-TGF-alpha should prove valuable as a possible tumor marker in colorectal cancers, and it may be very useful in understanding the biology of colorectal cancer.

Published
1991

43. A role of phospholipase A2 in cholesterol gallstone pathogenesis is associated with biliary phospholipid species subselection at a site of hepatic excretion

Author

Hattori, Y., primary, Tazuma, S., additional, Yamashita, G., additional, Sunami, Y., additional, Yasumiba, S., additional, Hyogo, H., additional, Nishioka, T., additional, Miyake, H., additional, Miura, H., additional, Kajihara, T., additional, Ochi, H., additional, and Kajiyama, G., additional

Published
1998
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