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1. Auditory cues reveal intended movement information in middle frontal gyrus neuronal ensemble activity of a person with tetraplegia

Author

Tommy Hosman, Jacqueline B. Hynes, Jad Saab, Kaitlin G. Wilcoxen, Bradley R. Buchbinder, Nicholas Schmansky, Sydney S. Cash, Emad N. Eskandar, John D. Simeral, Brian Franco, Jessica Kelemen, Carlos E. Vargas-Irwin, and Leigh R. Hochberg

Subjects
Medicine, Science
Abstract

Abstract Intracortical brain-computer interfaces (iBCIs) allow people with paralysis to directly control assistive devices using neural activity associated with the intent to move. Realizing the full potential of iBCIs critically depends on continued progress in understanding how different cortical areas contribute to movement control. Here we present the first comparison between neuronal ensemble recordings from the left middle frontal gyrus (MFG) and precentral gyrus (PCG) of a person with tetraplegia using an iBCI. As expected, PCG was more engaged in selecting and generating intended movements than in earlier perceptual stages of action planning. By contrast, MFG displayed movement-related information during the sensorimotor processing steps preceding the appearance of the action plan in PCG, but only when the actions were instructed using auditory cues. These results describe a previously unreported function for neurons in the human left MFG in auditory processing contributing to motor control.

Published
2021
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2. Neuromonitoring with pulse-train stimulation for implantation of thoracic pedicle screws: a blinded and randomized clinical study. Part 1. Methods and alarm criteria

Author

Kaitlin G Wilcoxen, Blair Calancie, Colin B Harris, Ross R Moquin, Miriam L Donohue, Gregory W Canute, and Amit Singla

Subjects
Male, medicine.medical_specialty, Thoracic Surgical Procedure, Thoracic spine, Bone Screws, Stimulation, Thoracic Vertebrae, Clinical study, Evoked Potentials, Somatosensory, Monitoring, Intraoperative, medicine, Humans, Spinal canal, Prospective Studies, Pedicle screw, business.industry, Electromyography, General Medicine, Middle Aged, Evoked Potentials, Motor, Evoked electromyography, Electric Stimulation, Surgery, medicine.anatomical_structure, Spinal Fusion, Treatment Outcome, Fluoroscopy, Thoracic vertebrae, Female, business
Abstract

ObjectReports of the accuracy of existing neuromonitoring methods for detecting or preventing medial malpositioning of thoracic pedicle screws have varied widely in their claimed effectiveness. The object of this study was to develop, test, and validate a novel neuromonitoring method for preventing medial malpositioning of pedicle screws in the thoracic spine during surgery.MethodsThis is a prospective, blinded and randomized study using a novel combination of input (4-pulse stimulus trains delivered within the pedicle track) and output (evoked electromyography from leg muscles) to detect pedicle track trajectories that—once implanted with a screw—would cause that screw to breach the pedicle's medial wall and encroach upon the spinal canal. For comparison, the authors also used screw stimulation as an input and evoked electromyogram from intercostal and abdominal muscles as output measures. Intraoperative electrophysiological findings were compared with postoperative CT scans by multiple reviewers blinded to patient identity or intraoperative findings.ResultsData were collected from 71 patients, in whom 802 screws were implanted between the T-1 and L-1 vertebral levels. A total of 32 screws ended up with screw threads encroaching on the spinal canal by at least 2 mm. Pulse-train stimulation within the pedicle track using a ball-tipped probe and electromyography from lower limb muscles correctly predicted all 32 (100%) of these medially malpositioned screws. The combination of pedicle track stimulation and electromyogram response from leg muscles proved to be far more effective in predicting these medially malpositioned screws than was direct screw stimulation and any of the target muscles (intercostal, abdominal, or lower limb muscles) we monitored. Based on receiver operating characteristic analysis, the combination of 10-mA (lower alarm) and 15-mA stimulation intensities proved most effective for detection of pedicle tracks that ultimately gave rise to medially malpositioned screws. Additional results pertaining to the impact of feedback of these test results on surgical decision making are provided in the companion report.ConclusionsThis novel neuromonitoring approach accurately predicts medially malpositioned thoracic screws. The approach could be readily implemented within any surgical program that is already using contemporary neuromonitoring methods that include transcranial stimulation for monitoring motor evoked potentials.

Published
2014

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