47 results on '"Kaine, Jeffrey"'
Search Results
2. Biosimilars
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Strand, Vibeke, primary, Kaine, Jeffrey, additional, and Isaacs, John, additional
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- 2020
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3. Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials of tofacitinib
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Strand, Vibeke, Kaine, Jeffrey, Alten, Rieke, Wallenstein, Gene, Diehl, Annette, Shi, Harry, Germino, Rebecca, and Murray, Christopher W.
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- 2020
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4. Tofacitinib 5 mg Twice Daily in Patients with Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs: A Comprehensive Review of Phase 3 Efficacy and Safety
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Bird, Paul, Bensen, William, El-Zorkany, Bassel, Kaine, Jeffrey, Manapat-Reyes, Bernadette Heizel, Pascual-Ramos, Virginia, Witcombe, David, Soma, Koshika, Zhang, Richard, and Thirunavukkarasu, Krishan
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- 2019
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5. Geographic Variation in Disease Burden and Mismatch in Care of Patients With Rheumatoid Arthritis in the United States
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Dowell, Sharon, primary, Yun, Huifeng, additional, Curtis, Jeffrey R., additional, Chen, Lang, additional, Xie, Fenglong, additional, Pedra‐Nobre, Manuela, additional, Wollaston, Dianne, additional, Najmey, Sawsan, additional, Elliott, Cynthia Lawrence, additional, Ford, Theresa Lawrence, additional, North, Heather, additional, Dore, Robin, additional, Dolatabadi, Soha, additional, Ramanujam, Thaila, additional, Kennedy, Stacy, additional, Ott, Stephanie, additional, Jileaeva, Ilona, additional, Richardson, Amina, additional, Kaine, Jeffrey, additional, Wright, Grace, additional, and Kerr, Gail S., additional
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- 2023
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6. Stratification, Specialization, and Proliferation of Primary Keratinocyte Cultures: Evidence of a Functioning in vitro Epidermal Cell System
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Marcelo, Cynthia L., Kim, Yong G., Kaine, Jeffrey L., and Voorhees, John J.
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- 1978
7. Long-Term Safety of Subcutaneous Abatacept in Rheumatoid Arthritis: Integrated Analysis of Clinical Trial Data Representing More Than Four Years of Treatment
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Alten, Rieke, Kaine, Jeffrey, Keystone, Edward, Nash, Peter, Delaet, Ingrid, and Genovese, Mark C.
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- 2014
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8. The effects of tocilizumab on osteitis, synovitis and erosion progression in rheumatoid arthritis: results from the ACT-RAY MRI substudy
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Conaghan, Philip G, Peterfy, Charles, Olech, Ewa, Kaine, Jeffrey, Ridley, David, DiCarlo, Julie, Friedman, Josh, Devenport, Jenny, and Troum, Orrin
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- 2014
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9. A Phase Ib Multiple Ascending Dose Study Evaluating Safety, Pharmacokinetics, and Early Clinical Response of Brodalumab (AMG 827), a Human Anti-Interleukin 17 Receptor (IL-17R) Antibody, in Rheumatoid Arthritis.: 1294
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Churchill, Melvin A., Flores-Suarez, Luis F., Wallace, Daniel J., Phillips, Kristine, Martin, Richard W., Cardiel, Mario H., Kaine, Jeffrey, Bautista, Edgar, Salinger, David H., Stevens, Erin, Russell, Christopher B., and Martin, David A.
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- 2012
10. Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase Iiib ALLOW study)
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Kaine, Jeffrey, Gladstein, Geoffrey, Strusberg, Ingrid, Robles, Manuel, Louw, Ingrid, Gujrathi, Sheila, Pappu, Ramesh, Delaet, Ingrid, Pans, Miranda, and Ludivico, Charles
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- 2012
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11. Evaluation of the safety of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis: Results from a randomized controlled trial
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Greenwald, Maria W., Shergy, William J., Kaine, Jeffrey L., Sweetser, Marianne T., Gilder, Kye, and Linnik, Matthew D.
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- 2011
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12. Understanding differences between men and women with axial spondyloarthritis
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Wright, Grace C., primary, Kaine, Jeffrey, additional, and Deodhar, Atul, additional
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- 2020
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13. Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial
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Deodhar, Atul, primary, van der Heijde, Désirée, additional, Gensler, Lianne S, additional, Kim, Tae-Hwan, additional, Maksymowych, Walter P, additional, Østergaard, Mikkel, additional, Poddubnyy, Denis, additional, Marzo-Ortega, Helena, additional, Bessette, Louis, additional, Tomita, Tetsuya, additional, Leung, Ann, additional, Hojnik, Maja, additional, Gallo, Gaia, additional, Li, Xiaoqi, additional, Adams, David, additional, Carlier, Hilde, additional, Sieper, Joachim, additional, Morin, Frederic, additional, Rahman, Proton, additional, Ariel, Federico, additional, Berman, Alberto, additional, Carrio, Judith, additional, Lucero, Eleonora, additional, Cocco, Jose Maldonado, additional, Hidalgo, Rodolfo Pardo, additional, Velasco, Jorge, additional, Viola, Diego O., additional, Grisar, Johannes, additional, Resch, Heinrich, additional, Scheinecker, Clemens, additional, Melazzi, Ana Claudia, additional, Roimicher, Luis, additional, Scotton, Antonio Scafuto, additional, Rodriguez, Aaron Alejandro Barrera, additional, Molina, Francisco Fidencio Cons, additional, Barragan, Sergio Duran, additional, Skinner, Cassandra M., additional, Tena, Cesar Francisco Pacheco, additional, Remus, Cesar Ricardo Ramos, additional, Rodriguez, Juan Cruz Rizo, additional, Hong, Seung-Jae, additional, Kang, Seong Wook, additional, Lee, Chang Keun, additional, Lee, Eun Bong, additional, Lee, Sang Heon, additional, Park, Min-Chan, additional, Lee, Sang-Hoon, additional, Dokoupilova, Eva, additional, Dvorak, Zdenek, additional, Malcova, Martina, additional, Pvelka, Karel, additional, Eklund, Kari K., additional, Jarvinen, Pentti, additional, Karjalainen, Anna, additional, Paimela, Leena, additional, Taniguchi, Yoshinori, additional, Tsuda, Tokutaro, additional, Tada, Kurisu, additional, Dobashi, Hiroaki, additional, Inui, Kentaro, additional, Ueki, Yukitaka, additional, Matsumoto, Yoshifuji, additional, Hatta, Kazuhiro, additional, Atsumi, Tatsuya, additional, Goto, Hitoshi, additional, Honjo, Shigeru, additional, Matsui, Kiyoshi, additional, Takakubo, Yuya, additional, Neeck, Gunther, additional, Wagner, Sylke, additional, Braun, Jürgen, additional, Blicharshi, Tomasz, additional, Dudek, Anna, additional, Hrycai, Pawel, additional, Plebanski, Rafal, additional, Drabiszcak-Piatkowska, Janina, additional, Brzezicki, Jan, additional, Krogulec, Marek, additional, Opris-Belinski, Daniela, additional, Ramazan, Ana Maria, additional, Tronaru, Luminita, additional, van de Sande, Marleen G., additional, Matsievskaya, Galina, additional, Schmidt, Evgeniya, additional, Stanislav, Marina, additional, Yakushin, Sergey, additional, Ershova, Olga, additional, Rebroy, Andrey, additional, Churchill, Melvin A., additional, Flint, Kathleen P., additional, Greenwald, Maria, additional, Howell, Mary P., additional, Kaine, Jeffrey L., additional, Kivitz, Alan, additional, Klein, Steven J., additional, Mueller, Eric C., additional, Peters, Eric A., additional, Querubin, Roel, additional, Sayers, Michael E., additional, Scoville, Craig D., additional, Shanahan, Joseph C., additional, Roseff, Richard, additional, Hull, John E., additional, Mallepalli, Jyothi R., additional, Sebai, Mohamed B., additional, Kimmel, Steven C., additional, Goddard, David H., additional, Mease, Philip J., additional, Harris, Mark D., additional, Mabaquiao, Arthur R., additional, Diegel, Roger J., additional, Thai, Christine, additional, Rivera, Tania L., additional, Perez-De Jesus, Amarilis, additional, Soto-Raices, Oscar, additional, Toro-Torres, Ramon, additional, and Pantojas, Carlos, additional
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- 2020
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14. Ocrelizumab, a Humanized Anti-CD20 Monoclonal Antibody, in the Treatment of Patients With Rheumatoid Arthritis: A phase I/II Randomized, Blinded, Placebo-Controlled, Dose-Ranging Study
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Genovese, Mark C., Kaine, Jeffrey L., Lowenstein, Mitchell B., Del Giudice, José, Baldassare, Andrew, Schechtman, Joy, Fudman, Edward, Kohen, Michael, Gujrathi, Sheila, Trapp, Robert G., Sweiss, Nadera J., Spaniolo, Greg, and Dummer, Wolfgang
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- 2008
15. Efficacy and Safety of Ixekizumab in the Treatment of Radiographic Axial Spondyloarthritis: Sixteen-Week Results From a Phase III Randomized, Double-Blind, Placebo-Controlled Trial in Patients With Prior Inadequate Response to or Intolerance of Tumor Necrosis Factor Inhibitors
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Deodhar, Atul, Poddubnyy, Denis, Pacheco‐Tena, Cesar, Salvarani, Carlo, Lespessailles, Eric, Rahman, Proton, Järvinen, Pentti, Sanchez‐Burson, Juan, Gaffney, Karl, Lee, Eun Bong, Krishnan, Eswar, Santisteban, Silvia, Li, Xiaoqi, Zhao, Fangyi, Carlier, Hilde, Reveille, John, Antolini, Christopher, Azevedo, Valderilio, Barkham, Magnus, Rodriguez, Aaron Alejandro Barrera, Berman, Alberto, Blicharski, Tomasz, Brzezicki, Jan, Burmester, Gerd, Carrio, Judith, Collantes, Eduardo, Combe, Bernard, Cons‐Molina, Fidencio, Cortes‐Maisonet, Gregorio, Dudek, Anna, Barragan, Sergio Duran, Elkayam, Ori, Flint, Kathleen, Galeazzi, Mauro, Gaylis, Norman, Goddard, David, Fernandez, Carlos Gonzalez, Goupille, Philippe, Masmitja, Jordi Gratacos, Greenwald, Maria, Gremese, Elisa, Hong, Seung Jae, Howell, Mary, Hrycaj, Pawel, Ince, Akgun, Ju, Ji Hyeon, Kaine, Jeffrey, Kang, Seong Wook, Keiserman, Mauro, Kim, Tae‐Hwan, Kivitz, Alan, Klein, Steven, Kremer, Joel, Lee, Sang Heon, Lee, Chang Keun, Lee, Sang‐Hoon, Lidman, Roger, Loveless, James, Lucero, Eleonora, Cocco, Jose Maldonado, Marcolino, Flora, Mariette, Xavier, Mehta, Daksha, Morin, Frederic, Moscovici, Yolanda, Mueller, Eric, Mysler, Eduardo, Blasco, Francisco Navarro, Nguyen, Minh, Pantojas, Carlos, Park, Min‐Chan, Jesus, Amarilis Perez‐De, Peters, Eric, Plebanski, Rafal, Querubin, Roel, Remus, Cesar Ramos, Reitblat, Tatiana, Rivera, Tania, Rodriguez, Juan Cruz Rizo, Sayers, Michael, Scotton, Antonio, Scoville, Craig, Shaw, David, Shin, Kichul, Singhal, Atul, Skinner, Cassandra, Soto‐Raices, Oscar, Soubrier, Martin, Szymanska, Malgorzata, Thai, Christine, Sande, Marleen, Wells, Alvin, Wojciechowski, Rafal, Xavier, Ricardo, Ximenes, Antonio, Zisman, Devy, Imagerie Multimodale Multiéchelle et Modélisation du Tissu Osseux et articulaire (I3MTO), Université d'Orléans (UO), Oregon Health and Science University [Portland] (OHSU), Universidad Autónoma de Chihuahua (UACH), Università degli Studi di Modena e Reggio Emilia, Memorial University of Newfoundland [St. John's], Seoul National University [Seoul] (SNU), Eli Lilly and Company [Indianapolis], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
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Adult ,Male ,Settore MED/16 - REUMATOLOGIA ,Immunology ,ankylosing spondylitis ,axial spondyloarthritis ,ixekizumab ,radiographic ,Antibodies, Monoclonal, Humanized ,Rheumatology ,Double-Blind Method ,Spondylarthritis ,Spondyloarthritis ,Immunology and Allergy ,Humans ,ComputingMilieux_MISCELLANEOUS ,Axis, Cervical Vertebra ,Middle Aged ,Spine ,Radiography ,Treatment Outcome ,[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system ,Antirheumatic Agents ,Quality of Life ,Female ,Tumor Necrosis Factor Inhibitors ,Original Article ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; OBJECTIVE:To investigate the efficacy and safety of ixekizumab in patients with active radiographic axial spondyloarthritis (SpA) and prior inadequate response to or intolerance of 1 or 2 tumor necrosis factor inhibitors (TNFi).METHODS:In this phase III randomized, double-blind, placebo-controlled trial, adult patients with an inadequate response to or intolerance of 1 or 2 TNFi and an established diagnosis of axial SpA (according to the Assessment of SpondyloArthritis international Society [ASAS] criteria for radiographic axial SpA, with radiographic sacroiliitis defined according to the modified New York criteria and ≥1 feature of SpA) were recruited and randomized 1:1:1 to receive placebo or 80-mg subcutaneous ixekizumab every 2 weeks (IXEQ2W) or 4 weeks (IXEQ4W), with an 80-mg or 160-mg starting dose. The primary end point was 40% improvement in disease activity according to the ASAS criteria (ASAS40) at week 16. Secondary outcomes and safety were also assessed.RESULTS:A total of 316 patients were randomized to receive placebo (n = 104), IXEQ2W (n = 98), or IXEQ4W (n = 114). At week 16, significantly higher proportions of IXEQ2W patients (n = 30 [30.6%]; P = 0.003) or IXEQ4W patients (n = 29 [25.4%]; P = 0.017) had achieved an ASAS40 response versus the placebo group (n = 13 [12.5%]), with statistically significant differences reported as early as week 1 with ixekizumab treatment. Statistically significant improvements in disease activity, function, quality of life, and spinal magnetic resonance imaging-evident inflammation were observed after 16 weeks of ixekizumab treatment versus placebo. Treatment-emergent adverse events (AEs) with ixekizumab treatment were more frequent than with placebo. Serious AEs were similar across treatment arms. One death was reported (IXEQ2W group).CONCLUSION:Ixekizumab treatment for 16 weeks in patients with active radiographic axial SpA and previous inadequate response to or intolerance of 1 or 2 TNFi yields rapid and significant improvements in the signs and symptoms of radiographic axial SpA versus placebo.
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- 2019
16. Failure to report previously used drugs and dosages in pharmaceutical company–sponsored rheumatoid arthritis trials: comment on the article by Yocum et al
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Yocum, David E., Furst, Daniel E., Kaine, Jeffrey L., Baldassare, Andrew, Stevenson, Jon T., Borton, Mary Ann, Wisemandle, Wayne, Mekki, Qais A., Mengle-Gaw, Laurel J., and Schwartz, Benjamin D.
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- 2004
17. Efficacy and Safety of Tacrolimus in Patients With Rheumatoid Arthritis: A Double-Blind Trial
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Yocum, David E., Furst, Daniel E., Kaine, Jeffrey L., Baldassare, Andrew R., Stevenson, Jon T., Borton, Mary Ann, Mengle-Gaw, Laurel J., Schwartz, Benjamin D., Wisemandle, Wayne, and Mekki, Qais A.
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- 2003
18. Tacrolimus in Rheumatoid Arthritis Patients Receiving Concomitant Methotrexate: A Six-Month, Open-Label Study
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Kremer, Joel M., Habros, Joseph S., Kolba, Karen S., Kaine, Jeffrey L., Borton, Mary Ann, Mengle-Gaw, Laurel J., Schwartz, Benjamin D., Wisemandle, Wayne, and Mekki, Qais A.
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- 2003
19. Concomitant Leflunomide Therapy in Patients with Active Rheumatoid Arthritis despite Stable Doses of Methotrexate: A Randomized, Double-Blind, Placebo-Controlled Trial
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Kremer, Joel M., Genovese, Mark C., Cannon, Grant W., Caldwell, Jacques R., Cush, John J., Furst, Daniel E., Luggen, Michael E., Keystone, Ed, Weisman, Michael H., Bensen, William M., Kaine, Jeffrey L., Ruderman, Eric M., Coleman, Patricia, Curtis, David L., Kopp, Elliot J., Kantor, Seth M., Waltuck, Jonathan, Lindsley, Herbert B., Markenson, Joseph A., Strand, Vibeke, Crawford, Bruce, Fernando, Indra, Simpson, Karen, and Bathon, Joan M.
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- 2002
20. Efficacy of Tacrolimus in Rheumatoid Arthritis Patients Who Have Been Treated Unsuccessfully With Methotrexate: A Six-Month, Double-Blind, Randomized, Dose-Ranging Study
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Furst, Daniel E., Saag, Kenneth, Fleischmann, Roy M, Sherrer, Yvonne, Block, Joel A., Schnitzer, Thomas, Rutstein, Joel, Baldassare, Andrew, Kaine, Jeffrey, Calabrese, Leonard, Dietz, Frederick, Sack, Marshall, Senter, Gordon R, Wiesenhutter, Craig, Schiff, Michael, Stein, Michael C, Satoi, Yoichi, Matsumoto, Alan, Caldwell, Jacques, Harris, Robert E., Moreland, Larry W., Hurd, Eric, Yocum, David, and Stamler, David A.
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- 2002
21. Two-Year, Blinded, Randomized, Controlled Trial of Treatment of Active Rheumatoid Arthritis With Leflunomide Compared With Methotrexate
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Cohen, Stanley, Cannon, Grant W., Schiff, Michael, Weaver, Arthur, Fox, Robert, Olsen, Nancy, Furst, Daniel, Sharp, John, Moreland, Larry, Caldwell, Jacques, Kaine, Jeffrey, and Strand, Vibeke
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- 2001
22. Higher Incidence Rates of Comorbidities in Patients with Psoriatic Arthritis Compared with the General Population Using U.S. Administrative Claims Data
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Kaine, Jeffrey, primary, Song, Xue, additional, Kim, Gilwan, additional, Hur, Peter, additional, and Palmer, Jacqueline B., additional
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- 2019
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23. Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial
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van der Heijde, Désirée, primary, Cheng-Chung Wei, James, additional, Dougados, Maxime, additional, Mease, Philip, additional, Deodhar, Atul, additional, Maksymowych, Walter P, additional, Van den Bosch, Filip, additional, Sieper, Joachim, additional, Tomita, Tetsuya, additional, Landewé, Robert, additional, Zhao, Fangyi, additional, Krishnan, Eswar, additional, Adams, David H., additional, Pangallo, Beth, additional, Carlier, Hilde, additional, Churchill, Melvin, additional, Flint, Kathleen, additional, Gladstein, Geoffrey, additional, Greenwald, Maria, additional, Howell, Mary, additional, Ince, Akgun, additional, Kaine, Jeffrey, additional, Mehta, Daksha, additional, Peters, Eric, additional, Querubin, Roel, additional, Reveille, John, additional, Roseff, Richard, additional, Diegel, Roger, additional, Thai, Christine, additional, Bessette, Louis, additional, Morin, Frederic, additional, Rahman, Proton, additional, Barrera Rodriguez, Aaron Alejandro, additional, Cons-Molina, Fidencio, additional, Duran Barragan, Sergio, additional, Skinner, Cassandra, additional, Pacheco Tena, Cesar, additional, Ramos Remus, Cesar, additional, Rizo Rodriguez, Juan Cruz, additional, Hong, Seung-Jae, additional, Lee, Yeon-Ah, additional, Ju, Ji Hyeon, additional, Kang, Seong Wook, additional, Kim, Tae-Hwan, additional, Lee, Chang Keun, additional, Lee, Eun Bong, additional, Lee, Sang Heon, additional, Park, Min-Chan, additional, Shin, Kichul, additional, Lee, Sang-Hoon, additional, Chen, Hung-An, additional, Chen, Ying-Chou, additional, Hsieh, Song-Chou, additional, Lan, Joung-Liang, additional, Dvorak, Zdenek, additional, Moravcova, Radka, additional, Malcova, Martina, additional, Taniguchi, Yoshinori, additional, Kishimoto, Mitsumasa, additional, Tada, Kurisu, additional, Dobashi, Hiroaki, additional, Inui, Kentaro, additional, Ueki, Yukitaka, additional, Matsumoto, Yoshifuji, additional, Koyama, Yoshinobu, additional, Hatta, Kazuhiro, additional, Atsumi, Tatsuya, additional, Goto, Hitoshi, additional, Matsui, Kiyoshi, additional, Takakubo, Yuya, additional, Neeck, Gunther, additional, Poddubnyy, Denis, additional, Rubbert-Roth, Andrea, additional, Szymanska, Malgorzata, additional, Blicharski, Tomasz, additional, Dudek, Anna, additional, Racewicz, Artur, additional, Wojciechowski, Rafal, additional, van de Sande, Marleen, additional, Griep, Ed, additional, Nurmohamed, Mike, additional, Matsievskaya, Galina, additional, Shmidt, Evgeniya, additional, Stanislav, Marina, additional, Yakushin, Sergey, additional, Ershova, Olga, additional, Rebrov, Andrey, additional, Balazs, Tibor, additional, Cseuz, Regina, additional, Drescher, Edit, additional, and Poor, Gyula, additional
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- 2018
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24. A pooled analysis of the safety of tofacitinib as monotherapy or in combination with background conventional synthetic disease-modifying antirheumatic drugs in a Phase 3 rheumatoid arthritis population
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Kivitz, Alan J., primary, Cohen, Stanley, additional, Keystone, Edward, additional, van Vollenhoven, Ronald F., additional, Haraoui, Boulos, additional, Kaine, Jeffrey, additional, Fan, Haiyun, additional, Connell, Carol A., additional, Bananis, Eustratios, additional, Takiya, Liza, additional, and Fleischmann, Roy, additional
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- 2018
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25. Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility
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Mehta, Puja, Holder, Susan, Fisher, Benjamin, Vincent, Tonia, Nadesalingam, Kavitha, Maciver, Helen, Shingler, Wendy, Bakshi, Jyoti, Hassan, Sadon, D'Cruz, David, Chan, Antoni, Litwic, Anna E., McCrae, Fiona, Seth, Rakhi, Nandagudi, Anupama, Jury, Elizabeth, Isenberg, David, Karjigi, Uma, Paul, Anupam, Rees, Frances, O'Dowd, Emma, Kinnear, William, Johnson, Simon, Lanyon, Peter, Stevens, Richard, Narayan, Nehal, Marguerie, Christopher, Robinson, Helena, Ffolkes, Lorrette, Worsnop, Fiona, Ostlere, Lucy, Kiely, Patrick, Dharmapalaiah, Chethana, Hassan, Nada, Bharadwaj, Anurag, Skibinska, Malgorzata, Gendi, Nagui, Davies, Emma J., Akil, Mohammed, Kilding, Rachael, Ramachandran Nair, Jagdish, Walsh, Maeve, Farrar, Wendy, Thompson, Robert N., Borukhson, Liubov, McFadyen, Charles, Singh, Deepwant, Rajagopal, Vivek, Chan, Angela Marie L., Wearn Koh, Li, Christie, Jennifer D., Croot, Lorraine, Gayed, Mary, Disney, Benjamin, Singhal, Saket, Grindulis, Karl, Reynolds, Timothy D., Conway, Katie, Williams, Debbie, Quin, John, Dean, Gillian, Churchill, Duncan, Walker-Bone, Karen E., Goff, Iain, Reynolds, Gary, Grove, Matthew, Patel, Priya, Lazarus, Mark N., Roncaroli, Frederico, Gabriel, Carolyn, Kinderlerer, Anne R., Nikiphorou, Elena, Hall, Frances C., Bruce, Ellen, Gray, Leanne, Krutikov, Maria, Wig, Surabhi, Bruce, Ian, D'Agostino, Maria A., Wakefield, Richard, Berner Hammer, Hilde, Vittecoq, Olivier, Galeazzi, Mauro, Balint, Peter, Filippucci, Emilio, Moller, Ingrid, Iagnocco, Annamaria, Naredo, Esperanza, Ostergaard, Mikkel, Gaillez, Corine, Kerselaers, Wendy, Van Holder, Karina, Le Bars, Manuela, Stone, Millicent A., Williams, Francis, Wolber, Lisa, Karppinen, Jaro, Maatta, Juhani, Thompson, Ben, Atchia, Ismael, Lorenzi, Alice, Raftery, Graham, Platt, Phil, Platt, Philip N., Pratt, Arthur, Turmezei, Thomas D., Treece, Graham M., Gee, Andrew H., Poole, Kenneth E., Chandratre, Priyanka N., Roddy, Edward, Clarson, Lorna, Richardson, Jane, Hider, Samantha, Mallen, Christian, Lieberman, Abigail, Prouse, Peter J., Mahendran, Prini, Samarawickrama, Amanda, Ottery, Faith D., Yood, Robert, Wolfson, Marsha, Ang, Andrea, Riches, Philip, Thomson, Janet, Nuki, George, Humphreys, Jennifer, Verstappen, Suzanne M., Chipping, Jacqueline, Hyrich, Kimme, Marshall, Tarnya, Symmons, Deborah P., Roy, Matthew, Kirwan, John R., Marshall, Robert W., Matcham, Faith, Scott, Ian C., Rayner, Lauren, Hotopf, Matthew, Kingsley, Gabrielle H., Scott, David L., Steer, Sophia, Ma, Margaret H., Dahanayake, Chanaka, Kingsley, Gabrielle, Cope, Andrew, Wernham, Aaron, Ward, Lorna, Carruthers, David, Deeming, Alison, Buckley, Christopher, Raza, Karim, De Pablo, Paola, Carpenter, Lewis, Jayakumar, Keeranur, Solymossy, Csilla, Dixey, Josh, Young, Adam, Singh, Animesh, Penn, Henry, Ellerby, Nicholas, Mattey, Derek L., Packham, Jonathan, Dawes, Peter, Hider, Samantha L., Ng, Nora, Humby, Frances, Bombardieri, Michele, Kelly, Stephen, Di Cicco, Maria, Dadoun, Sabrina, Hands, Rebecca, Rocher, Vidalba, Kidd, Bruce, Pyne, Dev, Pitzalis, Costantino, Poore, Sophie, Hutchinson, David, Low, Audrey, Lunt, Mark, Mercer, Louise, Galloway, James, Davies, Rebecca, Watson, Kath, Dixon, Will, Symmons, Deborah, Watson, Kath D., Dixon, William G., Hyrich, Kimme L., Malik, Saadia P., Kelly, Clive, Hamilton, Jennifer, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Harris, Helen E., Tweedie, Fiona, Skaparis, Yiannis, White, Marie, Scott, Nicola, Samson, Kay, Mercieca, Cecilia, Clarke, Shane, Warner, Alexander J., Verstappen, Suzanne, Chan, Esther, Woodhead, Felix A., Nisar, Mohamed, Arthanari, S., Dawson, Julie, Sathi, Nav, Ahmad, Yasmeen, Koduri, Gouri, Cumming, Jo, Stannett, Peter, Hull, Richard, Metsios, George, Stavropoulos Kalinoglou, Antonios, Veldhuijzen van Zanten, Jet J., Nightingale, Peter, Koutedakis, Yiannis, Kitas, George D., Williams, Peter, Walsh, David, Perry, Elizabeth, de-Soyza, Anthony, Moullaali, Thomas, Eggleton, Paul, Stavropoulos-Kalinoglou, Antonios, Sandoo, Aamer, de Pablo, Paola, Maggs, Fiona, Faizal, Abdul, Pugh, Mark, Jobanputra, Paresh, Kehoe, Oksana, Cartwright, Alison, Askari, Ayman, El Haj, Alicia, Middleton, Jim, Aynsley, Sarah, Hardy, Jacob, Veale, Douglas, Fearon, Ursula, Wilson, Gerry, Muthana, Munitta, Fossati, G., Healy, L., Nesbitt, A., Becerra, Elena, Leandro, Maria J., De La Torre, Inmaculada, Cambridge, Geraldine, Nelson, P. N., Roden, D., Shaw, M., Davari Ejtehadi, Hora, Nevill, A., Freimanis, G., Hooley, P., Bowman, S., Alavi, A., Axford, J., Veitch, A. M., Tugnet, N., Rylance, P. B., Hawtree, Sarah, Mark Wilkinson, J., Wilson, Anthony G., Woon Kam, Ngar, Filter, Andrew, Croft, Adam P., Naylor, Amy, Zimmermann, Birgit, Hardie, Debbie, Desanti, Guillaume, Jaurez, Maria, Muller-Ladner, Ulf, Filer, Andrew, Neumann, Elena, Movahedi, Mohammad, Ray, David W., Burmester, Gerd R., Matucci-Cerinic, Marco, Navarro-Blasco, Francisco, Kary, Sonja, Unnebrink, Kristina, Kupper, Hartmut, Mukherjee, Sandeep, Cornell, Patricia, Richards, Selwyn, Rahmeh, Fouz, Thompson, Paul W., Westlake, Sarah L., Javaid, Muhammad K., Batra, Rajbir, Chana, Jasroop, Round, Gemma, Judge, Andrew, Taylor, Peter, Patel, Sanjeev, Cooper, Cyrus, Ravindran, Vinod, Bingham, Clifton O., Weinblatt, Michael E., Mendelsohn, Alan, Kim, Lilianne, Mack, Michael, Lu, Jiandong, Baker, Daniel, Westhovens, Rene, Hewitt, Jamie, Han, Chenglong, Keystone, Edward C., Fleischmann, Roy, Smolen, Josef, Emery, Paul, Genovese, Mark, Doyle, Mittie, Hsia, Elizabeth C., Hart, Jennifer C., Harland, Dave, Gibbons, Carl, Pang, Hok, Huertas, Catherine, Diamantopoulos, Alex, Dejonckheere, Fred, Clowse, M., Wolf, D., Stach, C., Kosutic, G., Williams, S., Terpstra, I., Mahadevan, U., Ferraccioli, G., Samborski, W., Berenbaum, F., Davies, O., Koetse, W., Bennett, B., Burkhardt, H., Luijtens, K., van der Heijde, Desiree, Mariette, X., van Vollenhoven, Ronald F., Bykerk, V., de Longueville, M., Arendt, C., Cush, J., Khan, Afsha, Maclaren, Zoe, Dubash, Sayam, Chalam, Venkat C., Sheeran, Tom, Price, Tom, Baskar, Sangeetha, Mulherin, Diarmuid, Molloy, Cauline, Keay, Fiona, Heritage, Caroline, Douglas, Barbara, Schiff, Michael H., Khanna, Dinesh, Furst, Daniel E., Maldonado, Michael A., Li, Wanying, Sasso, Eric H., Emerling, Daniel, Cavet, Guy, Ford, Kerri, Mackenzie-Green, Bronwen, Collins, David, Price, Elizabeth, Williamson, Lyn, Golla, Janardhana, Vagadia, Vipul, Morrison, Elaine, Tierney, Ann, Wilson, Hilary, Hunter, John, Reddy, Venkat, Moore, Samantha, Ehrenstein, Michael, Benson, Claire, Wray, Maria, Cairns, Andrew, Wright, Gary, Pendleton, Adrian, McHenry, Michelle, Taggart, Allister, Bell, Aubrey, Bosworth, Ailsa, Cox, Maureen, Johnston, Graeme, Shah, Preeti, O'Brien, Anne, Jones, Peter, Sargeant, Ify, Bukhari, Marwan, Nusslein, Hubert, Alten, Rieke, Lorenz, Hannes M., Boumpas, Dimitrios, Nurmohamed, Michael T., Bensen, William, Peter, Hans-Hartmut, Rainer, Franz, Pavelka, Karel, Chartier, Melanie, Poncet, Coralie, Rauch, Christiane, Lempp, Heidi, Hofmann, Darija, Adu, Aderonke, Congreve, Carron, Dobson, Joanne, Rose, Diana, Simpson, Carol, Wykes, Til, Ibrahim, Fowzia, Schiff, Michael, Nash, Peter, Durez, Patrick, Kaine, Jeffrey, Delaet, Ingrid, Kelly, Sheila, Maldonado, Michael, Patel, Salil, Jones, Graeme, Sebba, Anthony, Lepley, Denise, Devenport, Jenny, Bernasconi, Corrado, Smart, Devi, Mpofu, Chiedzo, Gomez-Reino, Juan J., Verma, Inderjeet, Kaur, Jaspreet, Syngle, Ashit, Krishan, Pawan, Vohra, Kanchan, Kaur, Ladbans, Garg, Nidhi, Chhabara, Monica, Gibson, Kellie, Woodburn, James, Telfer, Scott, Buckley, Felicity, Finckh, Axel, Huizinga, Tom W., Jansen, Jeroen P., Rubbert-Roth, Andrea, Scali, Juan J., Kremer, Joel M., Pitts, Laura, Vernon, Emma, Sharif, Mohammed I., Das, Sudipto, Helliwell, Philip, Sokoll, Katharina, and Vital, Edward M.
- Subjects
cardiovascular system - Abstract
Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interest
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- 2017
26. Treatment of Active Rheumatoid Arthritis With Leflunomide Compared With Placebo and Methotrexate
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Strand, Vibeke, Cohen, Stanley, Schiff, Michael, Weaver, Arthur, Fleischmann, Roy, Cannon, Grant, Fox, Robert, Moreland, Larry, Olsen, Nancy, Furst, Dan, Caldwell, Jacques, Kaine, Jeffrey, Sharp, John, Hurley, Frank, and Loew-Friedrich, Iris
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- 1999
27. Effect of macitentan on the development of new ischemic digital ulcers in patients with systemic sclerosis: Dual-1 and Dual-2 randomized clinical trials
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Khanna, Dinesh, Denton, Christopher P., Merkel, Peter A., Krieg, Thomas M., Le Brun, Franck Olivier, Marr, Angelina, Papadakis, Kelly, Pope, Janet, Matucci Cerinic, Marco, Furst, Daniel E., Zochling, Jane, Stevens, Wendy, Proudman, Susanna, Feenstra, John, Youssef, Peter, Soroka, Nikolay, Tyabut, Tamara, Mikhailova, Elena Ivanovna, Rashkov, Rasho, Batalov, Anasta, Yablanski, Kiril, Keystone, Edward, Jones, Niall, Dunne, Jame, Masetto, Ariel, Calabresse, Renato Jiménez, Cabezas, Pedro Claudio Miranda, Silva, Marta Ofelia Aliste, Sariego, Imgadt Annelise Goecke, Escalente, William José Otero, Anić, Branimir, Kaliterna, Dušanka Martinović, Morović Vergles, Jadranka, Novak, Srdan, Prus, Višnja, Artuković, Marinko, Soukup, Tomaáš, Bečvař, Radim, Fojtík, Zdeněk, Mouthon, Luc, Kollert, Florian, Riemekasten, Gabriela, Lahner, Nina, Fierlbeck, Gerhard, Ahmadi Simab, Keihan, Diehm, Curt, Szücs, Gabriella, Kumánovics, Gábor, Nagy, György, Pal, Sarvajeet, Veeravalli, Sarath Chandra Mouli, Danda, Debashish, Ferri, Clodeveo, Cozzi, Franco, Ferraccioli, Gianfranco, Wiland, Piotr, Rudnicak, Lidia, Zwolak, Robert, Roszkiewicz, Jadwiga, Oleynikov, Valentin, Nikulenkova, Natalya, Lesnyak, Olga, Kaydashev, Igor, Kurytar, Oleksandr, Piura, Olena, Chopyak, Valentyna, Chatterjee, Soumya, Hsu, Vivien, Hummers, Laura, Martin, Richard, Domsic, Robyn, Schiopu, Elena, Shanahan, Joseph, Murphy, Frederik T., Kaine, Jeffrey, Davis, William, Grau, Rafael, Eimon, Alicia, Catoggio, Luis Jose, Laborde, Hugo Armando, Caeiro, Francisco, Savio, Veronica Gabriela, Amitrano, Cristina Beatriz, Vanthuyne, Marie, Zeng, Xioafeng, Zhang, Xiao, Zhu, Ping, Velásquez Franco, Carlos Jaime, Choueka, Philippe Selim Chalem, Sanchez, Patricia Julieta Vélez, Hermann, Walter, Sticherling, Michael, Steinbrink, Kerstin, Hein, Rüdiger, Aschoff, Roland, Sfikakis, Petro, Settas, Luka, Fraser, Alexander, Veale, Dougla, Balbir Gurman, Alexandra, Lidar, Merav, Litinsky, Irena, Levy, Yair, Carrillo Vazquez, Sandra Miriam, Rodriguez Reyna, Tatiana, Medrano Ramirez, Gabriel, Morales Torres, Jorge, Pacheco Tena, Cesar Francisco, Sanchez Ortiz, Adriana, Vonk, Madelon C., Stebbings, Simon, Solanki, Kamal, Steele, Richard, Ng, Kristine, Zubrzycka Sienkiewicz, Anna, Brzosko, Marek, Szepietowski, Jacek C., Hrycaj, Pawel, Da Silva, Ivone Fernandes Santo, Dos Santos, Lelita Da Conceiçao, Coelho, Paulo Jorge Clemente, Rios, Grissel, Chernykh, Tatiana, Grunina, Elena, Stanislav, Marina, Ally, Mahmood, Kalla, Asgar, Birlik, Ahmet Merih, Kovalenko, Volodymyr, Petrov, Andriy, Shevchuk, Sergiy, Stanislavchuk, Mykola, Anderson, Marina, Herrick, Ariane, Belch, Jill, Chung, Lorinda, Csuka, Mary Ellen, Frech, Tracy, Goldberg, Avram, Kahaleh, Bashar, Mayes, Maureen D., Rothfield, Naomi, Simms, Robert William, Spiera, Robert, Steen, Virgina, Varga, John, Sikes, David, Derk, Chris T., Kohen, Michael D., Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), Khanna, Dinesh, Denton, Christopher P., Merkel, Peter A., Krieg, Thomas M., Le Brun, Franck Olivier, Marr, Angelina, Papadakis, Kelly, Pope, Janet, Matucci Cerinic, Marco, Furst, Daniel E., Zochling, Jane, Stevens, Wendy, Proudman, Susanna, Feenstra, John, Youssef, Peter, Soroka, Nikolay, Tyabut, Tamara, Mikhailova, Elena Ivanovna, Rashkov, Rasho, Batalov, Anasta, Yablanski, Kiril, Keystone, Edward, Jones, Niall, Dunne, Jame, Masetto, Ariel, Calabresse, Renato Jiménez, Cabezas, Pedro Claudio Miranda, Silva, Marta Ofelia Aliste, Sariego, Imgadt Annelise Goecke, Escalente, William José Otero, Anić, Branimir, Kaliterna, Dušanka Martinović, Morović Vergles, Jadranka, Novak, Srdan, Prus, Višnja, Artuković, Marinko, Soukup, Tomaáš, Bečvař, Radim, Fojtík, Zdeněk, Mouthon, Luc, Kollert, Florian, Riemekasten, Gabriela, Lahner, Nina, Fierlbeck, Gerhard, Ahmadi Simab, Keihan, Diehm, Curt, Szücs, Gabriella, Kumánovics, Gábor, Nagy, György, Pal, Sarvajeet, Veeravalli, Sarath Chandra Mouli, Danda, Debashish, Ferri, Clodeveo, Cozzi, Franco, Ferraccioli, Gianfranco, Wiland, Piotr, Rudnicak, Lidia, Zwolak, Robert, Roszkiewicz, Jadwiga, Oleynikov, Valentin, Nikulenkova, Natalya, Lesnyak, Olga, Kaydashev, Igor, Kurytar, Oleksandr, Piura, Olena, Chopyak, Valentyna, Chatterjee, Soumya, Hsu, Vivien, Hummers, Laura, Martin, Richard, Domsic, Robyn, Schiopu, Elena, Shanahan, Joseph, Murphy, Frederik T., Kaine, Jeffrey, Davis, William, Grau, Rafael, Eimon, Alicia, Catoggio, Luis Jose, Laborde, Hugo Armando, Caeiro, Francisco, Savio, Veronica Gabriela, Amitrano, Cristina Beatriz, Vanthuyne, Marie, Zeng, Xioafeng, Zhang, Xiao, Zhu, Ping, Velásquez Franco, Carlos Jaime, Choueka, Philippe Selim Chalem, Sanchez, Patricia Julieta Vélez, Hermann, Walter, Sticherling, Michael, Steinbrink, Kerstin, Hein, Rüdiger, Aschoff, Roland, Sfikakis, Petro, Settas, Luka, Fraser, Alexander, Veale, Dougla, Balbir Gurman, Alexandra, Lidar, Merav, Litinsky, Irena, Levy, Yair, Carrillo Vazquez, Sandra Miriam, Rodriguez Reyna, Tatiana, Medrano Ramirez, Gabriel, Morales Torres, Jorge, Pacheco Tena, Cesar Francisco, Sanchez Ortiz, Adriana, Vonk, Madelon C., Stebbings, Simon, Solanki, Kamal, Steele, Richard, Ng, Kristine, Zubrzycka Sienkiewicz, Anna, Brzosko, Marek, Szepietowski, Jacek C., Hrycaj, Pawel, Da Silva, Ivone Fernandes Santo, Dos Santos, Lelita Da Conceiçao, Coelho, Paulo Jorge Clemente, Rios, Grissel, Chernykh, Tatiana, Grunina, Elena, Stanislav, Marina, Ally, Mahmood, Kalla, Asgar, Birlik, Ahmet Merih, Kovalenko, Volodymyr, Petrov, Andriy, Shevchuk, Sergiy, Stanislavchuk, Mykola, Anderson, Marina, Herrick, Ariane, Belch, Jill, Chung, Lorinda, Csuka, Mary Ellen, Frech, Tracy, Goldberg, Avram, Kahaleh, Bashar, Mayes, Maureen D., Rothfield, Naomi, Simms, Robert William, Spiera, Robert, Steen, Virgina, Varga, John, Sikes, David, Derk, Chris T., Kohen, Michael D., and Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428)
- Abstract
Importance: Digital ulcers in patients with systemic sclerosis are associated with pain and poor quality of life. Endothelin-1 promotes vasculopathy in systemic sclerosis after macitentan, an endothelin-1 blocker. Objective: To evaluate the efficacy of macitentan in reducing the number of new digital ulcers in patients with systemic sclerosis. Design, Setting, And Participants: Two international, randomized, double-blind, placebo-controlled trials (DUAL-1, DUAL-2) were conducted between January 2012 and February 2014. Participants were patients with systemic sclerosis and active digital ulcers at baseline. Target enrollment for each study was 285 patients. Interventions: Patients were randomized (1:1:1) to receive oral doses of 3 mg of macitentan, 10 mg of macitentan, or placebo once daily and stratified according to number of digital ulcers at baseline (≤3 or >3). Main Outcomes and Measures: The primary outcome for each trialwas the cumulative number of new digital ulcers from baseline to week 16. Treatment effect was expressed as the ratio between treatment groups. Results: In DUAL-1, among 289 randomized patients (mean age 51.2 years; 85.8% women), 226 completed the study. The adjusted mean number of new digital ulcers per patient over 16 weeks was 0.94 in the 3-mg macitentan group (n = 95) and 1.08 in the 10-mg macitentan group (n = 97) compared with 0.85 in the placebo group (n = 97) (absolute difference, 0.09 [95% CI, -0.37 to 0.54] for 3mg of macitentan vs placebo and 0.23 [-0.27 to 0.72] for 10 mg of macitentan vs placebo). Among 265 patients randomized in DUAL-2 (mean age 49.6 years; 81.9% women), 216 completed the study. In DUAL-2, the adjusted mean number of new digital ulcers was 1.44 in the 3-mg macitentan group (n = 88) and 1.46 in the 10-mg macitentan group (n = 88) compared with 1.21 in the placebo group (n = 89) (absolute difference, 0.23 [95% CI, -0.35 to 0.82] for 3 mg of macitentan vs placebo and 0.25 [95% CI, -0.34 to 0.84] for 10mg of macitenta
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- 2016
28. Complement and the Rheumatic Diseases
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ATKINSON, JOHN P., primary, KAINE, JEFFREY L., additional, MICHAEL HOLERS, V., additional, and CHAN, ANDREW C., additional
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- 1986
- Full Text
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29. THE KINETICS OF BINDING OF STEROIDS TO THE SOLUBLE GLUCOCORTICOID RECEPTOR OF L 929 MOUSE FIBROBLASTS AND RAT THYMOCYTES
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Pratt, William B., primary, Kaine, Jeffrey L., additional, Pratt, Diana V., additional, and Nielsen, Carl J., additional
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- 1977
- Full Text
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30. A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis
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Martin, David A, primary, Churchill, Melvin, additional, Flores-Suarez, Luis, additional, Cardiel, Mario H, additional, Wallace, Daniel, additional, Martin, Richard, additional, Phillips, Kristine, additional, Kaine, Jeffrey L, additional, Dong, Hua, additional, Salinger, David, additional, Stevens, Erin, additional, Russell, Chris B, additional, and Chung, James B, additional
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- 2013
- Full Text
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31. Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase Iiib ALLOW study)
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Kaine, Jeffrey, primary, Gladstein, Geoffrey, additional, Strusberg, Ingrid, additional, Robles, Manuel, additional, Louw, Ingrid, additional, Gujrathi, Sheila, additional, Pappu, Ramesh, additional, Delaet, Ingrid, additional, Pans, Miranda, additional, and Ludivico, Charles, additional
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- 2011
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32. Abatacept for the treatment of rheumatoid arthritis: A review
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Kaine, Jeffrey L., primary
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- 2007
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33. Reply
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Yocum, David E., primary, Furst, Daniel E., additional, Kaine, Jeffrey L., additional, Baldassare, Andrew, additional, Stevenson, Jon T., additional, Borton, Mary Ann, additional, Wisemandle, Wayne, additional, Mekki, Qais A., additional, Mengle-Gaw, Laurel J., additional, and Schwartz, Benjamin D., additional
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- 2004
- Full Text
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34. Treatment of Elderly Patients with Nabumetone or Diclofenac
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Morgan, G. James, primary, Kaine, Jeffrey, additional, DeLapp, Ralph, additional, and Palmer, Robert, additional
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- 2001
- Full Text
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35. A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-interleukin 17 receptor (IL-17R) antibody, in methotrexateresistant rheumatoid arthritis.
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Martin, David A., Churchill, Melvin, Flores-Suarez, Luis Felipe, Cardiel, Mario H., Wallace, Daniel, Martin, Richard, Phillips, Kristine, Kaine, Jeffrey L., Hua Dong, Salinger, David, Stevens, Erin, Russell, Chris B., and Chung, James B.
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- 2013
- Full Text
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36. The Rapid Assessment of Disease Activity in Rheumatology (Radar) Questionnaire
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Mason, John Hayes, primary, Anderson, Jennifer J., additional, Meenan, Robert F., additional, Haralson, Kathleen M., additional, Lewis-Stevens, Donna, additional, and Kaine, Jeffrey L., additional
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- 1992
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37. Polymyalgia rheumatica and temporal arteritis: Managing older patients.
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Pereira, Marybeth and Kaine, Jeffrey L.
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- 1986
38. Idiotypic characteristics of immunoglobulins associated with systemic lupus erythematosus. Studies of antibodies deposited in glomeruli of humans.
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Kalunian, Kenneth C., Panosian-Sahakian, Niver, Ebling, Fanny M., Cohen, Arthur H., Louie, James S., Kaine, Jeffrey, and Hahn, Bevra H.
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- 1989
- Full Text
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39. Ro (SS-A) antibody and antigen in a patient with congenital complete heart block.
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Harley, John B., Kaine, Jeffrey L., Fox, Owen F., Reichlin, Morris, and Gruber, Barry
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- 1985
- Full Text
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40. Immune Responses Following Administration of Influenza and Pneumococcal Vaccines to Patients with Rheumatoid Arthritis Receiving Adalimumab
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KAINE, JEFFREY, KIVITZ, ALAN, BIRBARA, CHARLES, and LUO, ALLISON
- Abstract
OBJECTIVE: This study compared the immunogenicity of influenza and pneumococcal vaccines in adult patients with rheumatoid arthritis (RA) receiving adalimumab or placebo. METHODS: In this double-blind, randomized, multicenter study, patients received adalimumab or placebo on Days 1, 15, and 29. Pneumococcal and influenza vaccines were administered on Day 8 (vaccine baseline). Vaccine response (≥ 2-fold titer increase from baseline in ≥ 3 of 5 pneumococcal antigens and ≥ 4-fold titer increase from baseline in ≥ 2 of 3 influenza antigens) and protective antibody titers (≥ 1.6 µg/ml pneumococcal antibody concentration to ≥ 3 of 5 antigens and ≥ 1:40 influenza antibody titer to ≥ 2 of 3 antigens) were analyzed 4 weeks' postvaccination. RESULTS: Following pneumococcal vaccination, percentages of patients achieving a vaccine response were similar in the adalimumab and placebo groups [37.4% and 40.4%, respectively; 95% CI (confidence interval) –16.2%, 10.3%]. Percentages of patients with protective antibody titers were similar in both treatment groups (adalimumab: 85.9%, placebo: 81.7%). Following influenza vaccination, percentages of patients achieving a vaccine response were lower with adalimumab than placebo (51.5% and 63.3%, respectively; 95% CI –25.2%, 1.6%) a result explained by the subgroup of patients with preexisting protective antibody titers at baseline. For patients without protective antibody titers at baseline, response rates were similar in the 2 groups (adalimumab: 73.3%, placebo: 73.9%). Percentages of patients with protective antibody titers were similar in both treatment groups (adalimumab: 98%, placebo: 94.5%). CONCLUSION: Patients with RA treated with adalimumab can be effectively and safely immunized with pneumococcal and influenza vaccines.
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- 2007
41. Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility
- Author
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Mehta, Puja, Holder, Susan, Fisher, Benjamin, Vincent, Tonia, Nadesalingam, Kavitha, Maciver, Helen, Shingler, Wendy, Bakshi, Jyoti, Hassan, Sadon, D'Cruz, David, Chan, Antoni, Litwic, Anna E., McCrae, Fiona, Seth, Rakhi, Nandagudi, Anupama, Jury, Elizabeth, Isenberg, David, Karjigi, Uma, Paul, Anupam, Rees, Frances, O'Dowd, Emma, Kinnear, William, Johnson, Simon, Lanyon, Peter, Stevens, Richard, Narayan, Nehal, Marguerie, Christopher, Robinson, Helena, Ffolkes, Lorrette, Worsnop, Fiona, Ostlere, Lucy, Kiely, Patrick, Dharmapalaiah, Chethana, Hassan, Nada, Bharadwaj, Anurag, Skibinska, Malgorzata, Gendi, Nagui, Davies, Emma J., Akil, Mohammed, Kilding, Rachael, Ramachandran Nair, Jagdish, Walsh, Maeve, Farrar, Wendy, Thompson, Robert N., Borukhson, Liubov, McFadyen, Charles, Singh, Deepwant, Rajagopal, Vivek, Chan, Angela Marie L., Wearn Koh, Li, Christie, Jennifer D., Croot, Lorraine, Gayed, Mary, Disney, Benjamin, Singhal, Saket, Grindulis, Karl, Reynolds, Timothy D., Conway, Katie, Williams, Debbie, Quin, John, Dean, Gillian, Churchill, Duncan, Walker-Bone, Karen E., Goff, Iain, Reynolds, Gary, Grove, Matthew, Patel, Priya, Lazarus, Mark N., Roncaroli, Frederico, Gabriel, Carolyn, Kinderlerer, Anne R., Nikiphorou, Elena, Hall, Frances C., Bruce, Ellen, Gray, Leanne, Krutikov, Maria, Wig, Surabhi, Bruce, Ian, D'Agostino, Maria A., Wakefield, Richard, Berner Hammer, Hilde, Vittecoq, Olivier, Galeazzi, Mauro, Balint, Peter, Filippucci, Emilio, Moller, Ingrid, Iagnocco, Annamaria, Naredo, Esperanza, Ostergaard, Mikkel, Gaillez, Corine, Kerselaers, Wendy, Van Holder, Karina, Le Bars, Manuela, Stone, Millicent A., Williams, Francis, Wolber, Lisa, Karppinen, Jaro, Maatta, Juhani, Thompson, Ben, Atchia, Ismael, Lorenzi, Alice, Raftery, Graham, Platt, Phil, Platt, Philip N., Pratt, Arthur, Turmezei, Thomas D., Treece, Graham M., Gee, Andrew H., Poole, Kenneth E., Chandratre, Priyanka N., Roddy, Edward, Clarson, Lorna, Richardson, Jane, Hider, Samantha, Mallen, Christian, Lieberman, Abigail, Prouse, Peter J., Mahendran, Prini, Samarawickrama, Amanda, Ottery, Faith D., Yood, Robert, Wolfson, Marsha, Ang, Andrea, Riches, Philip, Thomson, Janet, Nuki, George, Humphreys, Jennifer, Verstappen, Suzanne M., Chipping, Jacqueline, Hyrich, Kimme, Marshall, Tarnya, Symmons, Deborah P., Roy, Matthew, Kirwan, John R., Marshall, Robert W., Matcham, Faith, Scott, Ian C., Rayner, Lauren, Hotopf, Matthew, Kingsley, Gabrielle H., Scott, David L., Steer, Sophia, Ma, Margaret H., Dahanayake, Chanaka, Kingsley, Gabrielle, Cope, Andrew, Wernham, Aaron, Ward, Lorna, Carruthers, David, Deeming, Alison, Buckley, Christopher, Raza, Karim, De Pablo, Paola, Carpenter, Lewis, Jayakumar, Keeranur, Solymossy, Csilla, Dixey, Josh, Young, Adam, Singh, Animesh, Penn, Henry, Ellerby, Nicholas, Mattey, Derek L., Packham, Jonathan, Dawes, Peter, Hider, Samantha L., Ng, Nora, Humby, Frances, Bombardieri, Michele, Kelly, Stephen, Di Cicco, Maria, Dadoun, Sabrina, Hands, Rebecca, Rocher, Vidalba, Kidd, Bruce, Pyne, Dev, Pitzalis, Costantino, Poore, Sophie, Hutchinson, David, Low, Audrey, Lunt, Mark, Mercer, Louise, Galloway, James, Davies, Rebecca, Watson, Kath, Dixon, Will, Symmons, Deborah, Watson, Kath D., Dixon, William G., Hyrich, Kimme L., Malik, Saadia P., Kelly, Clive, Hamilton, Jennifer, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Harris, Helen E., Tweedie, Fiona, Skaparis, Yiannis, White, Marie, Scott, Nicola, Samson, Kay, Mercieca, Cecilia, Clarke, Shane, Warner, Alexander J., Verstappen, Suzanne, Chan, Esther, Woodhead, Felix A., Nisar, Mohamed, Arthanari, S., Dawson, Julie, Sathi, Nav, Ahmad, Yasmeen, Koduri, Gouri, Cumming, Jo, Stannett, Peter, Hull, Richard, Metsios, George, Stavropoulos Kalinoglou, Antonios, Veldhuijzen van Zanten, Jet J., Nightingale, Peter, Koutedakis, Yiannis, Kitas, George D., Williams, Peter, Walsh, David, Perry, Elizabeth, de-Soyza, Anthony, Moullaali, Thomas, Eggleton, Paul, Stavropoulos-Kalinoglou, Antonios, Sandoo, Aamer, de Pablo, Paola, Maggs, Fiona, Faizal, Abdul, Pugh, Mark, Jobanputra, Paresh, Kehoe, Oksana, Cartwright, Alison, Askari, Ayman, El Haj, Alicia, Middleton, Jim, Aynsley, Sarah, Hardy, Jacob, Veale, Douglas, Fearon, Ursula, Wilson, Gerry, Muthana, Munitta, Fossati, G., Healy, L., Nesbitt, A., Becerra, Elena, Leandro, Maria J., De La Torre, Inmaculada, Cambridge, Geraldine, Nelson, P. N., Roden, D., Shaw, M., Davari Ejtehadi, Hora, Nevill, A., Freimanis, G., Hooley, P., Bowman, S., Alavi, A., Axford, J., Veitch, A. M., Tugnet, N., Rylance, P. B., Hawtree, Sarah, Mark Wilkinson, J., Wilson, Anthony G., Woon Kam, Ngar, Filter, Andrew, Croft, Adam P., Naylor, Amy, Zimmermann, Birgit, Hardie, Debbie, Desanti, Guillaume, Jaurez, Maria, Muller-Ladner, Ulf, Filer, Andrew, Neumann, Elena, Movahedi, Mohammad, Ray, David W., Burmester, Gerd R., Matucci-Cerinic, Marco, Navarro-Blasco, Francisco, Kary, Sonja, Unnebrink, Kristina, Kupper, Hartmut, Mukherjee, Sandeep, Cornell, Patricia, Richards, Selwyn, Rahmeh, Fouz, Thompson, Paul W., Westlake, Sarah L., Javaid, Muhammad K., Batra, Rajbir, Chana, Jasroop, Round, Gemma, Judge, Andrew, Taylor, Peter, Patel, Sanjeev, Cooper, Cyrus, Ravindran, Vinod, Bingham, Clifton O., Weinblatt, Michael E., Mendelsohn, Alan, Kim, Lilianne, Mack, Michael, Lu, Jiandong, Baker, Daniel, Westhovens, Rene, Hewitt, Jamie, Han, Chenglong, Keystone, Edward C., Fleischmann, Roy, Smolen, Josef, Emery, Paul, Genovese, Mark, Doyle, Mittie, Hsia, Elizabeth C., Hart, Jennifer C., Harland, Dave, Gibbons, Carl, Pang, Hok, Huertas, Catherine, Diamantopoulos, Alex, Dejonckheere, Fred, Clowse, M., Wolf, D., Stach, C., Kosutic, G., Williams, S., Terpstra, I., Mahadevan, U., Ferraccioli, G., Samborski, W., Berenbaum, F., Davies, O., Koetse, W., Bennett, B., Burkhardt, H., Luijtens, K., van der Heijde, Desiree, Mariette, X., van Vollenhoven, Ronald F., Bykerk, V., de Longueville, M., Arendt, C., Cush, J., Khan, Afsha, Maclaren, Zoe, Dubash, Sayam, Chalam, Venkat C., Sheeran, Tom, Price, Tom, Baskar, Sangeetha, Mulherin, Diarmuid, Molloy, Cauline, Keay, Fiona, Heritage, Caroline, Douglas, Barbara, Schiff, Michael H., Khanna, Dinesh, Furst, Daniel E., Maldonado, Michael A., Li, Wanying, Sasso, Eric H., Emerling, Daniel, Cavet, Guy, Ford, Kerri, Mackenzie-Green, Bronwen, Collins, David, Price, Elizabeth, Williamson, Lyn, Golla, Janardhana, Vagadia, Vipul, Morrison, Elaine, Tierney, Ann, Wilson, Hilary, Hunter, John, Reddy, Venkat, Moore, Samantha, Ehrenstein, Michael, Benson, Claire, Wray, Maria, Cairns, Andrew, Wright, Gary, Pendleton, Adrian, McHenry, Michelle, Taggart, Allister, Bell, Aubrey, Bosworth, Ailsa, Cox, Maureen, Johnston, Graeme, Shah, Preeti, O'Brien, Anne, Jones, Peter, Sargeant, Ify, Bukhari, Marwan, Nusslein, Hubert, Alten, Rieke, Lorenz, Hannes M., Boumpas, Dimitrios, Nurmohamed, Michael T., Bensen, William, Peter, Hans-Hartmut, Rainer, Franz, Pavelka, Karel, Chartier, Melanie, Poncet, Coralie, Rauch, Christiane, Lempp, Heidi, Hofmann, Darija, Adu, Aderonke, Congreve, Carron, Dobson, Joanne, Rose, Diana, Simpson, Carol, Wykes, Til, Ibrahim, Fowzia, Schiff, Michael, Nash, Peter, Durez, Patrick, Kaine, Jeffrey, Delaet, Ingrid, Kelly, Sheila, Maldonado, Michael, Patel, Salil, Jones, Graeme, Sebba, Anthony, Lepley, Denise, Devenport, Jenny, Bernasconi, Corrado, Smart, Devi, Mpofu, Chiedzo, Gomez-Reino, Juan J., Verma, Inderjeet, Kaur, Jaspreet, Syngle, Ashit, Krishan, Pawan, Vohra, Kanchan, Kaur, Ladbans, Garg, Nidhi, Chhabara, Monica, Gibson, Kellie, Woodburn, James, Telfer, Scott, Buckley, Felicity, Finckh, Axel, Huizinga, Tom W., Jansen, Jeroen P., Rubbert-Roth, Andrea, Scali, Juan J., Kremer, Joel M., Pitts, Laura, Vernon, Emma, Sharif, Mohammed I., Das, Sudipto, Helliwell, Philip, Sokoll, Katharina, Vital, Edward M., Mehta, Puja, Holder, Susan, Fisher, Benjamin, Vincent, Tonia, Nadesalingam, Kavitha, Maciver, Helen, Shingler, Wendy, Bakshi, Jyoti, Hassan, Sadon, D'Cruz, David, Chan, Antoni, Litwic, Anna E., McCrae, Fiona, Seth, Rakhi, Nandagudi, Anupama, Jury, Elizabeth, Isenberg, David, Karjigi, Uma, Paul, Anupam, Rees, Frances, O'Dowd, Emma, Kinnear, William, Johnson, Simon, Lanyon, Peter, Stevens, Richard, Narayan, Nehal, Marguerie, Christopher, Robinson, Helena, Ffolkes, Lorrette, Worsnop, Fiona, Ostlere, Lucy, Kiely, Patrick, Dharmapalaiah, Chethana, Hassan, Nada, Bharadwaj, Anurag, Skibinska, Malgorzata, Gendi, Nagui, Davies, Emma J., Akil, Mohammed, Kilding, Rachael, Ramachandran Nair, Jagdish, Walsh, Maeve, Farrar, Wendy, Thompson, Robert N., Borukhson, Liubov, McFadyen, Charles, Singh, Deepwant, Rajagopal, Vivek, Chan, Angela Marie L., Wearn Koh, Li, Christie, Jennifer D., Croot, Lorraine, Gayed, Mary, Disney, Benjamin, Singhal, Saket, Grindulis, Karl, Reynolds, Timothy D., Conway, Katie, Williams, Debbie, Quin, John, Dean, Gillian, Churchill, Duncan, Walker-Bone, Karen E., Goff, Iain, Reynolds, Gary, Grove, Matthew, Patel, Priya, Lazarus, Mark N., Roncaroli, Frederico, Gabriel, Carolyn, Kinderlerer, Anne R., Nikiphorou, Elena, Hall, Frances C., Bruce, Ellen, Gray, Leanne, Krutikov, Maria, Wig, Surabhi, Bruce, Ian, D'Agostino, Maria A., Wakefield, Richard, Berner Hammer, Hilde, Vittecoq, Olivier, Galeazzi, Mauro, Balint, Peter, Filippucci, Emilio, Moller, Ingrid, Iagnocco, Annamaria, Naredo, Esperanza, Ostergaard, Mikkel, Gaillez, Corine, Kerselaers, Wendy, Van Holder, Karina, Le Bars, Manuela, Stone, Millicent A., Williams, Francis, Wolber, Lisa, Karppinen, Jaro, Maatta, Juhani, Thompson, Ben, Atchia, Ismael, Lorenzi, Alice, Raftery, Graham, Platt, Phil, Platt, Philip N., Pratt, Arthur, Turmezei, Thomas D., Treece, Graham M., Gee, Andrew H., Poole, Kenneth E., Chandratre, Priyanka N., Roddy, Edward, Clarson, Lorna, Richardson, Jane, Hider, Samantha, Mallen, Christian, Lieberman, Abigail, Prouse, Peter J., Mahendran, Prini, Samarawickrama, Amanda, Ottery, Faith D., Yood, Robert, Wolfson, Marsha, Ang, Andrea, Riches, Philip, Thomson, Janet, Nuki, George, Humphreys, Jennifer, Verstappen, Suzanne M., Chipping, Jacqueline, Hyrich, Kimme, Marshall, Tarnya, Symmons, Deborah P., Roy, Matthew, Kirwan, John R., Marshall, Robert W., Matcham, Faith, Scott, Ian C., Rayner, Lauren, Hotopf, Matthew, Kingsley, Gabrielle H., Scott, David L., Steer, Sophia, Ma, Margaret H., Dahanayake, Chanaka, Kingsley, Gabrielle, Cope, Andrew, Wernham, Aaron, Ward, Lorna, Carruthers, David, Deeming, Alison, Buckley, Christopher, Raza, Karim, De Pablo, Paola, Carpenter, Lewis, Jayakumar, Keeranur, Solymossy, Csilla, Dixey, Josh, Young, Adam, Singh, Animesh, Penn, Henry, Ellerby, Nicholas, Mattey, Derek L., Packham, Jonathan, Dawes, Peter, Hider, Samantha L., Ng, Nora, Humby, Frances, Bombardieri, Michele, Kelly, Stephen, Di Cicco, Maria, Dadoun, Sabrina, Hands, Rebecca, Rocher, Vidalba, Kidd, Bruce, Pyne, Dev, Pitzalis, Costantino, Poore, Sophie, Hutchinson, David, Low, Audrey, Lunt, Mark, Mercer, Louise, Galloway, James, Davies, Rebecca, Watson, Kath, Dixon, Will, Symmons, Deborah, Watson, Kath D., Dixon, William G., Hyrich, Kimme L., Malik, Saadia P., Kelly, Clive, Hamilton, Jennifer, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Harris, Helen E., Tweedie, Fiona, Skaparis, Yiannis, White, Marie, Scott, Nicola, Samson, Kay, Mercieca, Cecilia, Clarke, Shane, Warner, Alexander J., Verstappen, Suzanne, Chan, Esther, Woodhead, Felix A., Nisar, Mohamed, Arthanari, S., Dawson, Julie, Sathi, Nav, Ahmad, Yasmeen, Koduri, Gouri, Cumming, Jo, Stannett, Peter, Hull, Richard, Metsios, George, Stavropoulos Kalinoglou, Antonios, Veldhuijzen van Zanten, Jet J., Nightingale, Peter, Koutedakis, Yiannis, Kitas, George D., Williams, Peter, Walsh, David, Perry, Elizabeth, de-Soyza, Anthony, Moullaali, Thomas, Eggleton, Paul, Stavropoulos-Kalinoglou, Antonios, Sandoo, Aamer, de Pablo, Paola, Maggs, Fiona, Faizal, Abdul, Pugh, Mark, Jobanputra, Paresh, Kehoe, Oksana, Cartwright, Alison, Askari, Ayman, El Haj, Alicia, Middleton, Jim, Aynsley, Sarah, Hardy, Jacob, Veale, Douglas, Fearon, Ursula, Wilson, Gerry, Muthana, Munitta, Fossati, G., Healy, L., Nesbitt, A., Becerra, Elena, Leandro, Maria J., De La Torre, Inmaculada, Cambridge, Geraldine, Nelson, P. N., Roden, D., Shaw, M., Davari Ejtehadi, Hora, Nevill, A., Freimanis, G., Hooley, P., Bowman, S., Alavi, A., Axford, J., Veitch, A. M., Tugnet, N., Rylance, P. B., Hawtree, Sarah, Mark Wilkinson, J., Wilson, Anthony G., Woon Kam, Ngar, Filter, Andrew, Croft, Adam P., Naylor, Amy, Zimmermann, Birgit, Hardie, Debbie, Desanti, Guillaume, Jaurez, Maria, Muller-Ladner, Ulf, Filer, Andrew, Neumann, Elena, Movahedi, Mohammad, Ray, David W., Burmester, Gerd R., Matucci-Cerinic, Marco, Navarro-Blasco, Francisco, Kary, Sonja, Unnebrink, Kristina, Kupper, Hartmut, Mukherjee, Sandeep, Cornell, Patricia, Richards, Selwyn, Rahmeh, Fouz, Thompson, Paul W., Westlake, Sarah L., Javaid, Muhammad K., Batra, Rajbir, Chana, Jasroop, Round, Gemma, Judge, Andrew, Taylor, Peter, Patel, Sanjeev, Cooper, Cyrus, Ravindran, Vinod, Bingham, Clifton O., Weinblatt, Michael E., Mendelsohn, Alan, Kim, Lilianne, Mack, Michael, Lu, Jiandong, Baker, Daniel, Westhovens, Rene, Hewitt, Jamie, Han, Chenglong, Keystone, Edward C., Fleischmann, Roy, Smolen, Josef, Emery, Paul, Genovese, Mark, Doyle, Mittie, Hsia, Elizabeth C., Hart, Jennifer C., Harland, Dave, Gibbons, Carl, Pang, Hok, Huertas, Catherine, Diamantopoulos, Alex, Dejonckheere, Fred, Clowse, M., Wolf, D., Stach, C., Kosutic, G., Williams, S., Terpstra, I., Mahadevan, U., Ferraccioli, G., Samborski, W., Berenbaum, F., Davies, O., Koetse, W., Bennett, B., Burkhardt, H., Luijtens, K., van der Heijde, Desiree, Mariette, X., van Vollenhoven, Ronald F., Bykerk, V., de Longueville, M., Arendt, C., Cush, J., Khan, Afsha, Maclaren, Zoe, Dubash, Sayam, Chalam, Venkat C., Sheeran, Tom, Price, Tom, Baskar, Sangeetha, Mulherin, Diarmuid, Molloy, Cauline, Keay, Fiona, Heritage, Caroline, Douglas, Barbara, Schiff, Michael H., Khanna, Dinesh, Furst, Daniel E., Maldonado, Michael A., Li, Wanying, Sasso, Eric H., Emerling, Daniel, Cavet, Guy, Ford, Kerri, Mackenzie-Green, Bronwen, Collins, David, Price, Elizabeth, Williamson, Lyn, Golla, Janardhana, Vagadia, Vipul, Morrison, Elaine, Tierney, Ann, Wilson, Hilary, Hunter, John, Reddy, Venkat, Moore, Samantha, Ehrenstein, Michael, Benson, Claire, Wray, Maria, Cairns, Andrew, Wright, Gary, Pendleton, Adrian, McHenry, Michelle, Taggart, Allister, Bell, Aubrey, Bosworth, Ailsa, Cox, Maureen, Johnston, Graeme, Shah, Preeti, O'Brien, Anne, Jones, Peter, Sargeant, Ify, Bukhari, Marwan, Nusslein, Hubert, Alten, Rieke, Lorenz, Hannes M., Boumpas, Dimitrios, Nurmohamed, Michael T., Bensen, William, Peter, Hans-Hartmut, Rainer, Franz, Pavelka, Karel, Chartier, Melanie, Poncet, Coralie, Rauch, Christiane, Lempp, Heidi, Hofmann, Darija, Adu, Aderonke, Congreve, Carron, Dobson, Joanne, Rose, Diana, Simpson, Carol, Wykes, Til, Ibrahim, Fowzia, Schiff, Michael, Nash, Peter, Durez, Patrick, Kaine, Jeffrey, Delaet, Ingrid, Kelly, Sheila, Maldonado, Michael, Patel, Salil, Jones, Graeme, Sebba, Anthony, Lepley, Denise, Devenport, Jenny, Bernasconi, Corrado, Smart, Devi, Mpofu, Chiedzo, Gomez-Reino, Juan J., Verma, Inderjeet, Kaur, Jaspreet, Syngle, Ashit, Krishan, Pawan, Vohra, Kanchan, Kaur, Ladbans, Garg, Nidhi, Chhabara, Monica, Gibson, Kellie, Woodburn, James, Telfer, Scott, Buckley, Felicity, Finckh, Axel, Huizinga, Tom W., Jansen, Jeroen P., Rubbert-Roth, Andrea, Scali, Juan J., Kremer, Joel M., Pitts, Laura, Vernon, Emma, Sharif, Mohammed I., Das, Sudipto, Helliwell, Philip, Sokoll, Katharina, and Vital, Edward M.
- Abstract
Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MR
42. Cerebroretinal Vasculopathy
- Author
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Grand, M. Gilbert, primary, Kaine, Jeffrey, additional, Fulling, Keith, additional, Atkinson, John, additional, Dowton, S. Bruce, additional, Farber, Martha, additional, Craver, Jeffrey, additional, and Rice, Karen, additional
- Published
- 1988
- Full Text
- View/download PDF
43. Detection of human autoantibodies specific for 5′-m7GMP and m7G(5′)ppp(5′)N
- Author
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Munns, Theodore W., primary, Liszewski, M.Kathryn, additional, Freeman, Sandra K., additional, and Kaine, Jeffrey L., additional
- Published
- 1985
- Full Text
- View/download PDF
44. 953 NUCLEOLAR ANTI-HISTONES (H) ANTIBODIES (Ab) INJUVENILE DERMATOMYOSITIS
- Author
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Arroyave, Carlos M, primary, Pachman, Lauren M, additional, Rich, Kenneth C, additional, Passo, Murray, additional, Kaine, Jeffrey L, additional, Spencer, Charles H, additional, and Nickeson, Robert W, additional
- Published
- 1985
- Full Text
- View/download PDF
45. 953 NUCLEOLAR ANTIHISTONES H ANTIBODIES Ab INJUVENILE DERMATOMYOSITIS
- Author
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Arroyave, Carlos M., Pachman, Lauren M., Rich, Kenneth C., Passo, Murray, Kaine, Jeffrey L., Spencer, Charles H., and Nickeson, Robert W.
- Published
- 1985
46. 1034 - THE KINETICS OF BINDING OF STEROIDS TO THE SOLUBLE GLUCOCORTICOID RECEPTOR OF L 929 MOUSE FIBROBLASTS AND RAT THYMOCYTES
- Author
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Pratt, William B., Kaine, Jeffrey L., Pratt, Diana V., and Nielsen, Carl J.
- Published
- 1977
- Full Text
- View/download PDF
47. Tofacitinib 5 mg Twice Daily in Patients with Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs: A Comprehensive Review of Phase 3 Efficacy and Safety.
- Author
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Bird P, Bensen W, El-Zorkany B, Kaine J, Manapat-Reyes BH, Pascual-Ramos V, Witcombe D, Soma K, Zhang R, and Thirunavukkarasu K
- Subjects
- Clinical Trials, Phase III as Topic, Humans, Janus Kinase Inhibitors administration & dosage, Janus Kinase Inhibitors adverse effects, Treatment Outcome, Antirheumatic Agents classification, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Piperidines administration & dosage, Piperidines adverse effects, Pyrimidines administration & dosage, Pyrimidines adverse effects, Pyrroles administration & dosage, Pyrroles adverse effects
- Abstract
Background: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We performed a comprehensive review of phase 3 studies of tofacitinib 5 mg twice daily (BID) (approved dose in many countries) in patients with moderate to severe RA and inadequate response to prior disease-modifying antirheumatic drugs., Methods: A search of PubMed and ClinicalTrials.gov identified 5 studies: ORAL Solo (NCT00814307), ORAL Sync (NCT00856544), ORAL Standard (included adalimumab 40 mg once every 2 weeks; NCT00853385), ORAL Scan (NCT00847613), and ORAL Step (NCT00960440). Efficacy and safety data for tofacitinib 5 mg BID, placebo, and adalimumab were analyzed., Results: Across the 5 studies, 1216 patients received tofacitinib 5 mg BID, 681 received placebo, and 204 received adalimumab. At month 3, tofacitinib demonstrated significantly higher 20%, 50%, and 70% improvement in American College of Rheumatology response criteria (ACR20, ACR50, and ACR70, respectively) response rates, greater improvement in Health Assessment Questionnaire-Disability Index, and a higher proportion of Disease Activity Score-defined remission than placebo. Frequencies of adverse events (AEs), serious AEs, and discontinuations due to AEs were similar for tofacitinib and placebo at month 3; serious infection events were more frequent for tofacitinib. In ORAL Standard, although not powered for formal comparisons, tofacitinib and adalimumab had numerically similar efficacy and AEs; serious AEs and serious infection events were more frequent with tofacitinib., Conclusions: Tofacitinib 5 mg BID reduced RA signs and symptoms and improved physical function versus placebo in patients with inadequate response to prior disease-modifying antirheumatic drugs. Tofacitinib 5 mg BID had a consistent, manageable safety profile across studies, with no new safety signals identified.
- Published
- 2019
- Full Text
- View/download PDF
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