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1. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
Published: 2023
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2. MMUNOLOGICAL FEATURES OF MACROPHAGES ASSOCIATED WITH METASTASIS OF PRIMARY BREAST CARCINOMA INTO REGIONAL LYMPH NODES

Author: Aikian A. Z., Shynkevych V. I., and Kaidashev I. P.
Subjects: tumor-associated macrophages, immunohistochemical studies, cd68+tam and cd163+m2-like macrophages., Medicine, Biology (General), QH301-705.5
Abstract: Aim. Breast cancer (BC) is a heterogeneous disease which develops under the selective “pressure” of the tumor microenvironment. Therefore, it is promising and important to study tumor-associated macrophages as the innate immunity cells. The innate immunity system supposedly is able to regulate tumor immune surveillance and does not necessarily require the innate link. Object and methods. Materials of the study were intraoperative tissue of tumors and ipsilateral lymph nodes in radical mastectomy. Immunohistochemical characteristics of removed tumors (ER, PR, HER2, Ki67) were used for organizing two balanced groups of patients with primary BC. In the first group, there were no metastases into the regional lymph nodes, N0, whereas in the second one there was primary metastatic BC, N1. The groups included three patients with non-luminal HER2+, luminal A, luminal HER2-negative, luminal HER2+, and triple-negative BC, with 15 patients in each group, with a total of 30 patients. Results. The main idea of the work was to find the differences between the quantities of CD68+ and CD163+ macrophages, localized in tumor biopsy samples between the groups of patients with non-metastatic BC (N0) and with metastases (N1), balanced by the clinical values of ER, PR, HER2 (non-luminal HER2+, luminal A, luminal B HER2+, luminal B HER2-, and triple-negative BC). The results of statistical processing of average quantitative indicators of CD68+TAM, CD163+M2-like macrophages and CD68/CD163 (macrophage index M1) between groups N0 and N1 did not reveal a significant difference. However, when comparing the calculated immune-positive macrophages from all fields of view (40×lens), which were 5-17 for each specimen, a significant increase in CD68+TAM in the metastasis group was established. Comparison of average quantitative indicators of CD68+, CD163+ and CD68/CD163 between groups BC N0 and N1 showed no significant differences (the Mann-Whitney test). We determined the IHC characteristics of BC for each biopsy sample, including Ki67 and G-grade. Therefore, a statistical check of their correlation relationships with average quantitative indicators of CD68+, CD163+ and CD68/CD163 macrophages was conducted, which revealed a reliable relationship between CD68+ and Ki67, expressed as a percentage, and between ER/PR (in the clinical interpretation: +/-) and CD68+, CD163+, but not CD68/CD163.Conclusions. 1. The number of CD68+TAM was significantly higher in the focus of the primary BC of patients with metastases in the regional lymph nodes. 2. We detected a reverse correlation between CD68+TAM, CD163+M2-like macrophages and the clinical value of ER/PR. Consequently, an increase in the number of TAMs (in particular, M2) in the primary ER+/ PR+BC with metastases may not have a predictive value for metastasis, or ER+/PR+ BC possibly metastasizes without a significant increase in TAM. 3. The revealed differences are confirmed by reliable statistical calculations and relate to the effect of an exceptionally pathological process, since patients did not receive treatment before radical mastectomy. 4. Interpretation of personal data on the number of CD68+TAM and CD163+M2- like macrophages still needs to be developed.
Published: 2020
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3. THE ROLE OF POLYMORPHISM OF THE COLLAGEN GENE 1 TYPE OF ALPHA-2 (COL1A2) (RS42524) IN THE DIAGNOSTIC METHODS OF THE EVALUATION OF POST-OPERATIVE SKIN SCARS LOCALIZED IN DIFFERENT AREAS OF THE HEAD AND NECK

Author: Buhanchenko O. P., Avetikov D. S., Shlikova O. A., Lokes K. P., and Kaidashev I. P.
Subjects: pathological scar, rgb system, collagen gene polymorphism, diagnostics., Medicine, Biology (General), QH301-705.5
Abstract: The problem of diagnosing scars of the head and neck begins important in modern society. This is due to the high incidence of different types of scar tissue, their ineffective treatment, and possible recurrences. One of the causes of pathological scars is the disruption of the collagen gene polymorphism that encodes it. However, data on the value of the polymorphic variant of the collagen type I gene in the formation of pathological conditions of the skin are rather limited. Today according to literature there are disparate data on the differential diagnosis of pathological scars, all of them are not systematized and need the optimization. Object and methods. To study the polymorphism of the COL1A2 gene (rs42524), 60 patients were examined. All patients have got cicatricial tissue localized in different areas of the head and neck and were treated at the Department of Maxillofacial Surgery of Poltava State Clinical Hospital. Additional examination of scar tissue was performed by analyzing digital images in Adobe Photoshop CC using a color system RGB. Results and Discussion. We have studied the differences in the external state of scar tissue, depending on the genotype in a group of patients with pathological scars in different topographoanatomical areas of the head and neck. The scar tissues were evaluated using features such as scar consistency, color, sensitivity, and scar area, without considering the scar tissue type by the author’s standardized system for the external evaluation of cicatricial tissue. Patients with pathological scars in different topographic and anatomical regions of the head and neck, which are carriers of the allele C (genotypes GC and CC), have more pronounced signs of low-grade chronic inflammation of the skin. The obtained data about association of the polymorphism gene COL1A2 (rs42524) with signs of low-grade chronic inflammation of the skin in patients with pathological scars in different areas of the head and neck, probably indicate a possible effect of single-nucleus replacement on the physiological functions of collagen, namely the collagen specific collaboration with different molecules and cells. Using the RGB system, it was established that using the RGB color systems in Adobe Photoshop makes it possible to differentiate the types of pathological scars of the head and neck depending on the intensity of color spectrum. It was noted the relationship between the presence of the polymorphic variant of the COL1A2 gene (rs42524) in the genotype and data of RGB examination among patients with scars in different areas of the head and neck that were separated in previous studies, by the types of scars in 4 groups according to the type of scar. At present, there is no optimized method of differential diagnosis of different types of scars of the head and neck, which is why there is a necessity to develop an informative and economically feasible method of diagnosis. Conclusions. It is possible to determine precisely the type of scar and, depending on the type, to choose the optimal method of surgery or conservative therapy by using the RGB system and determining the type of scar, taking into account the effect gene polymorphism of collagen 1 alpha-2 (COL1A2) (rs42524) on cicatricial tissue formation.
Published: 2019
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4. QUANTITATIVE CHARACTERISTICS OF CD68+ AND CD163+ MACROPHAGES IN THE PRIMARY FOCUS AND IN METASTATIC LESIONS OF REGIONAL LYMPH NODES IN TRIPLE-NEGATIVE INVASIVE BREAST CARCINOMA

Author: Aikian A. Z. and Kaidashev I. P.
Subjects: tumor-associated macrophages, immunohistochemical studies, CD68+ and CD163+, triple-negative subgroup, breast cancer, Medicine, Biology (General), QH301-705.5
Abstract: The triple-negative subgroup of breast cancer (TNBC) (estrogen, progesterone-, and HER2-receptor negatives) often affects young women and usually has a worse prognosis as compared to other types of BC. Recently, a complex role of the immune system in the growth, elimination and metastasis became an object of increased attention, promising to provide clinical prognostic markers of progression, as well as targets for the treatment of a wide range of tumors, including TNBC. In BC in general and in TNBC in particular, tumor-associated macrophages (TAM) are mainly associated with a worse prognosis, but their composition, apparently, varies between individual cases of TNBC. Thus, the research of TAM in TNBC is relevant, and therefore the aim of this study was to examine the quantitative parameters and features of localization of CD68+ and CD163+M2-like TAMs, which infiltrate TNBC in the primary focus without metastases and in paired samples with metastases in the lymph nodes, as well as the pathomorphological characteristics of this type of BC to determine their contribution to metastasis. Biopsy samples and clinical data were obtained from patients undergoing treatment at Poltava Regional Clinical Dispensary. The study was approved by the Ethics Commission of Ukrainian Medical Stomatological Academy. Materials of the study were intraoperative tumor tissues and ipsilateral lymph nodes in radically removed mammary glands without neoadjuvant treatment. Immunohistochemical (IHC) characteristics of the removed tumors (HER2, ER, PR, Ki67) were used to distinguish the TNBC group. According to the meta-analysis, the use of CD68 as a biomarker for TAM for IHC evaluation has its priorities, as compared with the individual definition of CD163 or CD206. We analyzed two subgroups of TNBC, balanced by the N0/1 status, 3 samples in each, and 3 samples of metastases in the lymph nodes, respectively. The average age of patients was 64 years, from 52 to 76. Primary-metastatic BC was observed in all patients in the 2nd, N1 group. Morphological and IHC findings were obtained according to the criteria for determining the molecular and biological subtype. IHC studies for determining TAM and M2-like macrophages were performed using the streptavidin-peroxidase method. The evaluation of immunohistochemical coloring was performed by counting CD68+TAM and CD163+M2-like TAMs under the light microscope (Biolam, LOMO, Russia: lens ?40, eyepiece ?7) in 7-10 fields of view of the intensive ICH-reaction of each section, calculating the arithmetic mean, within the tumor nests and tumor stroma. The count included immunopositive cells with macrophage morphology. Microphotographs were obtained using the Leica DM500 microscope, Leica, Germany (lens ? 4, 40). The statistical analysis was carried out using the GraphPad Prism 5 software, using nonparametric, parametric and simulation methods. The study is organized as a descriptive pathomorphological comparison between the two groups: N0 and N1, triple-negative BC, comparison of quantitative characteristics of CD68+ and CD163+M2-like fraction of TAM, as well as for verification of possible correlation relations between the quantitative characteristics of macrophages in the primary tumor and in the corresponding metastasis in the ipsilateral axillary lymph nodes. Increased level of infiltration of the primary focus of TNBC with CD68+TAM and CD163+M2-like macrophages is reliably associated with metastasis. It is assumed that the M1-like subpopulation of TAM most closely contacts with tumor nests in TNBC, which may be a prerequisite for the spread of the tumor, or metastasis. Primary premetastatic effects of TNBC may be related to the increase of not only M2, but also M1 macrophages. In metastatic lymph nodes, the amount of CD68+TAM was significantly lower than that of primary TNBC, whereas the quantitative indices of CD163+M2 correlated. Along with the localization and co-localization of CD68+ and CD163+M2-like TAMs, the results conform with the generally accepted paradigm that M1 TAM has an anti-tumoral but lower potential and M2 the protumoral one, but this is shown for metastases in the regional lymph nodes in primary-metastatic TNBC. Precise quantitative TAM indices for the use in clinical practice have not been developed, although their pathogenetic significance and quantitative variations are reliable according to metastasis and other clinical data of TNBC.
Published: 2018
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5. IL-26 in the induced sputum is associated with the level of systemic inflammation, lung functions and body weight in COPD patients

Author: Savchenko L, Mykytiuk M, Cinato M, Tronchere H, Kunduzova O, and Kaidashev I
Subjects: COPD, obesity, interleukin-26, induced sputum., Diseases of the respiratory system, RC705-779
Abstract: Lesia Savchenko,1 Marina Mykytiuk,1 Mathieu Cinato,2,3 Helene Tronchere,2,3 Oxana Kunduzova,2,3 Igor Kaidashev1 1Ukrainian Medical Stomatological Academy, Poltava, Ukraine; 2National Institute of Health and Medical Research (INSERM) U1048, Toulouse, France; 3Department of Internal Medicine, University of Toulouse, UPS, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France Background: Chronic inflammatory process is the main link in COPD pathogenesis, which causes structural changes in the respiratory tract and lungs. In overweight patients, an adipose tissue could contribute to activation of the inflammatory process. Therefore, it is highly important to identify potential biomarkers of inflammation for patients with COPD and obesity. The aim of this study was to investigate the role of interleukin-26 (IL-26) and evaluate the relationship between the level of systemic inflammation, lung function, and body mass index (BMI) in patients with COPD.Patients and methods: Eighty-three patients with COPD in the stable condition (stage 2 according to the 2016 Global Initiative for Chronic Obstructive Lung Disease recommendations), aged 40–70 years, were included in the study. All patients were divided into 2 groups: obese (n=53) (BMI – 30.0–39.9 kg/m2) and non-obese (n=30) (BMI – 18.5–24.9 kg/m2). We conducted patients’ examination, spirometry, induced the sputum, determined the level of C-reactive protein (CRP), leptin in serum and IL-26 in sputum.Results: Obese and non-obese COPD patients had a significant increase in IL-26 compared with healthy subjects by 2.3 and 2.6 (P=0.0003). We also observed a higher level of CRP by 1.38 times (P=0.0008), compared with the rate in non-obese COPD patients, and by 1.8 times (P=0.015) higher concentration level of leptin compared with healthy subjects. The sputum IL-26 level had positive correlation with BMI, CRP, and leptin, and a negative – with forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity. Leptin level had positive correlation with BMI and CRP, and negative with FEV1, FEV1/forced vital capacity.Conclusion: Obese COPD patients had a higher level of persistent systemic inflammation than non-obese ones, which is confirmed by a significant increase of CRP and leptin in serum. The data confirm that IL-26 can be considered as a perspective marker to detect the inflammation level in lung tissue of COPD patients. Keywords: COPD, obesity, interleukin-26, induced sputum
Published: 2018

6. Current Views on the Role of the Pro-Inflammatory Cytokine IL-26 in the Development and Clinical Course of Bronchial Asthma Associated with Obesity and Treatment Strategy

Author: Avramenko, Ya. M., primary and Kaidashev, I. P., additional
Published: 2023
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7. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
Published: 2017
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8. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J., Hellings, P. W., Agache, I., Bedbrook, A., Bachert, C., Bergmann, K. C., Bewick, M., Bindslev-Jensen, C., Bosnic-Anticevitch, S., Bucca, C., Caimmi, D. P., Camargos, P. A. M., Canonica, G. W., Casale, T., Chavannes, N. H., Cruz, A. A., De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W. J., Guldemond, N. A., Haahtela, T., Illario, M., Just, J., Keil, T., Klimek, L., Kuna, P., Larenas-Linnemann, D., Morais-Almeida, M., Mullol, J., Murray, R., Naclerio, R., O’Hehir, R. E., Papadopoulos, N. G., Pawankar, R., Potter, P., Ryan, D., Samolinski, B., Schunemann, H. J., Sheikh, A., Simons, F. E. R., Stellato, C., Todo-Bom, A., Tomazic, P. V., Valiulis, A., Valovirta, E., Ventura, M. T., Wickman, M., Young, I., Yorgancioglu, A., Zuberbier, T., Aberer, W., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ankri, J., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I., Barbara, C., Barbagallo, M., Bateman, E. D., Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Białoszewski, A. Z., Bieber, T., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camuzat, T., Cardona, V., Carreiro-Martins, P., Carriazo, A. M., Carlsen, K. H., Carr, W., Cepeda Sarabia, A. M., Cesari, M., Chatzi, L., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., de Sousa, J. Correia, Cox, L., Crooks, G., Custovic, A., Dahlen, S. E., Darsow, U., Dedeu, T., Deleanu, D., Denburg, J. A., De Vries, G., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink Wagner, A., Fiocchi, A., Fletcher, M., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioğlu, B., Gereda, J. E., van Wick, R. Gerth, González Diaz, S., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O’. B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E. J., Jeandel, C., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Jutel, M., Kaidashev, I., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Kardas, P., Keith, P. K., Kerkhof, M., Kerstjens, H. A. M., Khaltaev, N., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kuitunen, M., Kull, I., Kvedariene, V., Lambrecht, B., Lau, S., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K. C., Louis, R., Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Mösges, R., Muraro, A., Namazova-Baranova, L., Nadif, R., Neffen, H., Nekam, K., Nieto, A., Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T. D., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Palkonen, S., Panzner, P., Papi, A., Park, H. S., Passalacqua, G., Pedersen, S., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodriguez-Mañas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Scichilone, N., Schmid-Grendelmeier, P., Serrano, E., Shields, M., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, J., Thijs, C., Triggiani, M., Valenta, R., Valero, A., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Varona, L. L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Werfel, T., Whalley, B., Williams, D. M., Williams, S., Wilson, N., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., and Zidarn, M.
Published: 2016
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9. TLR4 896A/G gene polymorphism, rather than the TLR4 1196C/T and TLR2 2258G/A gene polymorphisms, determines the severe and aggravated course of atopic dermatitis in children

Author: Levchenko, L. Yu., Izmailova, O. V., Shlykova, O. A., and Kaidashev, I. P.
Published: 2013
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10. Role of toll-like receptor 2 and 4 gene polymorphisms in the development of allergic diseases with increased IgE levels

Author: Kutsenko, N. L., Izmailova, O. V., Vesnina, L. E., and Kaidashev, I. P.
Published: 2012
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11. Relationship between the TLR2 and TLR4 gene polymorphisms with a predisposition to certain urogenital infections

Author: Izmailova, O. V., Shlykova, O. A., Bobrova, N. O., and Kaidashev, I. P.
Published: 2011
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12. DYNAMICS OF CLINICAL AND LABORATORY INDICATORS IN THE TREATMENT OF PATIENTS WITH PSORIASIS AND CONCOMITANT ALIMENTARY OBESITY

Author: Yemchenko, Ya. A., primary, Ishcheikin, K. Ye., additional, and Kaidashev, I. P., additional
Published: 2021
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13. IL-33 AS A BIOMARKER OF INFLAMMATORY ACTIVITY IN PSORIASIS PATIENTS WITH CONCOMITANT OBESITY

Author: Yemchenko, Ya. O., primary, Ischeikin, K. Ye., additional, Kaidashev, I. P., additional, and Izmailova, O. V., additional
Published: 2021
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14. FEATURES OF CLINICAL AND LABORATORY PARAMETERS AND CLINICAL COURSE OF PSORIASIS IN PATIENTS WITH CONCOMITANT ALIMENTARY OBESITY

Author: Yemchenko, Ya. O., primary, Ischeikin, K. Ye., additional, and Kaidashev, I. P., additional
Published: 2021
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15. PROFESSOR SERHIY BORYSOVYCH BEZSHAPOCHNYY (TO THE 75TH ANNIVERSARY OF HIS BIRTH)

Author: Zhdan, V. M., primary, Lysak, V. P., additional, Dvornik, V. M., additional, Kaidashev, I. P., additional, Avetikov, D. S., additional, Ksyonz, I. V., additional, Loburets, V. V., additional, Bezega, М. І., additional, and Ryadnova, V. V., additional
Published: 2021
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16. The problem of hypersensitivity to local anesthetics

Author: Zaikov, S. V., primary, Kaidashev, I. P., additional, and Gumeniuk, G. L., additional
Published: 2020
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17. PPAR-Gamma Agonist Pioglitazone Reduced CD68+ but Not CD163+ Macrophage Dermal Infiltration in Obese Psoriatic Patients

Author: Yemchenko, Ya. O., primary, Shynkevych, V. I., additional, Ishcheikin, K. Ye, additional, and Kaidashev, I. P., additional
Published: 2020
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18. THE IL-33/ST2 SYSTEM REGULATES INFLAMMATION IN BRONCHOPULMONARY DISEASES

Author: Bilko, V. V., primary and Kaidashev, I. P., additional
Published: 2020
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19. Внесок макрофагів у патогенез хронічного пародонтиту у людини та перспективи дослідження. Огляд літератури

Author: Shynkevych, V. I. and Kaidashev, I. P.
Subjects: хронический пародонтит, макрофаги, хронічний пародонтит, chronic periodontitis, macrophages
Abstract: The role of macrophages in chronic periodontitis (CP) is essential, but not well understood.The purpose was a thematic analysis of the literature on contribution of M1/M2 macrophage subpopulations to the pathogenesis of chronic periodontitis, and methodology for macrophages study in order to define directions and approaches for further investigations.Our own research findings as well as papers for the topic by searching the electronic databases (the Google Scholar, PMC, PubMed) were analyzed.M1 macrophages can contribute to CP exacerbation, systemic inflammation enhancement, destruction of periodontal ligament, and inhibition of osteoclastogenesis. M2 macrophages are able both to develop tolerance influenced by LPS of periodontopathogens, and to enhance proinflammatory abilities. Experimental depletion of macrophages using clodronate liposomes can prevent the bone resorption. Influences on M1/M2 in CP with the purpose of treatment are not adequately investigated.Polarization of macrophages is regulated by a wide spectrum of recognizing receptors, cytokines, specific signaling pathways and genetic programs, some of which are used as phenotype markers of certain macrophages. The unique molecules for M1/M2 are absent. Phenotypic markers of M1 and M2 show overlap, so markers combinations are used depending on a purpose and type of macrophages or profile/combination of expressed genes. The article lists markers used in various studies for M1/M2 identification.Conclusions. Most of the data on the role of M1/M2 in CP was obtained using monocyte-derived macrophages in vitro and in animal models. This paper highlights the important role of M1 and M2 subpopulations of macrophages in the pathogenesis of CP in humans. The identification of predominant macrophage phenotypes remains elusive, as well as consequences of influences on them. Immunohistochemical methods are indispensable for human studies at the present stage due to availability of biopsy.A prospect for further scientific research is to study the role of M1 and M2 macrophages in CP pathogenesis in humans., Роль макрофагов при хроническом пародонтите (ХП) неотъемлема, но недостаточно выяснена.Цель работы – тематический анализ научной литературы, посвященной вкладу М1/М2 макрофагов в патогенез хронического пародонтита, а также методик исследований этих клеток для определения направления и подходов дальнейших исследований.Проанализированы научные статьи по теме поисковых систем Академия Google, PMC, PubMed и результаты собственных исследований.М1 макрофаги могут привносить вклад в начале обострения ХП в усиление общего воспаления, в разрушение периодонта, а также способствовать подавлению остеокластогенеза. М2 макрофаги способны развивать толерантность (под влиянием ЛПС пародонтопатогенных микроорганизмов) и усиливать свой провоспалительный потенциал. Экспериментальное истощение всех макрофагов (с использованием липосом клодроната) может предотвращать резорбцию костной ткани пародонта. Влияниe на М1/М2 при ХП для лечения мало исследованы.Поляризация макрофагов регулируется широким спектром распознающих рецепторов, цитокинов, специфических сигнальных путей и генетических программ, ряд из которых используют как маркеры определенного фенотипа макрофагов. Уникальные молекулы для М1 и М2 отсутствуют. Фенотипические маркеры М1/М2 частично совпадают, поэтому в исследованиях определяют их сочетание или набор/комбинацию экспрессированных генов. Перечислены маркеры, которые использовали в различных исследованиях для идентификации М1 и М2.Выводы. Большинство сведений о роли М1/М2 при ХП получены in vitro на макрофагах моноцитарного происхождения и на моделях у животных. Макрофаги и их субпопуляции М1 и М2 имеют важную роль в патогенезе ХП у человека. Преобладающие фенотипы макрофагов остаются неуловимыми, как и последствия воздействий на них. Методы иммуногистохимии незаменимы на данном этапе исследований у человека, учитывая доступность биопсийного материала., Роль макрофагів при хронічному пародонтиті (ХП) невіддільна, але недостатньо з’ясована.Мета роботи – тематичний аналіз фахової літератури щодо внеску М1/М2 макрофагів у патогенез хронічного пародонтиту, а також методик досліджень макрофагів для визначення напряму, підходів наступних досліджень.Проаналізували наукові статті за темою, що дібрані в пошукових системах Академія Google, PMC, PubMed, та власні дослідження.М1 макрофаги можуть робити внесок на початку загострення ХП у посилення загального запалення, руйнування періодонта, а також зумовлювати пригнічення остеокластогенезу. М2 макрофаги можуть розвивати толерантність (під впливом ЛПС пародонтопатогенних мікроорганізмів) і посилювати власний прозапальний потенціал. Експериментальне виснаження всіх макрофагів (з використанням ліпосом клодронату) може запобігати резорбції кісткової тканини пародонтf. Впливи на М1/М2 при ХП для лікування мало досліджені.Поляризація макрофагів регулюється широким спектром розпізнавальних рецепторів, цитокінів, специфічних сигнальних шляхів і генетичних програм, ряд з них використовують як маркери певного фенотипу макрофагів. Унікальні молекули для М1/М2 відсутні. Фенотипові маркери М1/М1 частково збігаються, тому в дослідженнях визначають їх комбінацію або набір/комбінацію експресованих генів. Наведено перелік маркерів, які використовували в різних дослідженнях для ідентифікації М1 і М2.Висновки. Більшість відомостей щодо ролі М1/М2 при ХП отримані in vitro на макрофагах моноцитарного походження й на моделях у тварин. Макрофаги та їхні субпопуляції М1 і М2 відіграють важливу роль у патогенезі ХП у людини. Фенотипи макрофагів, які переважають, залишається невизначеними, як і наслідки впливів на них. Методи імуногістохімії є незамінними на цьому етапі досліджень у людини, враховуючи доступність біопсійного матеріалу.
Published: 2019

20. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)(Clin Transl Allergy (2016) 6 (29) DOI: 10.1186/s13601-016-0116-9)

Author: Bousquet, Jean, Farrell, J., Crooks, George, Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, Niels H., Sousa, J. Correia de, Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, Anna, Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Kheder, A. B., Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, Thierry, Carlsen, K. H., Carr, W., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, David J., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Blay, F. De, Dedeu, Antoni, Deleanu, D., Keenoy, E. De Manuel, Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H. B., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, Leonardo M., Fletcher, M., Fiocchi, A., Fink-Wagner, A., Fonseca, J. A., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, Judith, Gemicioǧlu, B., Gereda, J. E., Diaz, S. González, Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, Claude, Jenkins, C., Johnston, S. L., Jonquet, Olivier, Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Khaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, Tuyen D., Lieberman, P., Lipworth, B. J., Li, J., Carlsen, K. C. Lodrup, Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P. J., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R. N., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D. S., Price, D., Rabe, K. F., Raciborski, F., Radier-Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, K. M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, Jordi, Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Ganse, E. Van, Hage, M. van, Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, Jacques, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Bousquet, J., Farrell, J., Crooks, G., Hellings, P., Bel, E. H., Bewick, M., Chavannes, N. H., De Sousa, J. C., Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, A., Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Kheder, A. B., Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, T., Carlsen, K. H., Carr, W., Carriazo, A., Casale, T., Cepeda Sarabia, A. M., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, D. J., Custovic, A., Dahl, R., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., De Manuel Keenoy, E., Demoly, P., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, L. M., Fletcher, M., Fiocchi, A., Fink Wagner, A., Fonseca, J., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, J., Gemicioglu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzman, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, C., Jenkins, C., Johnston, S. L., Jonquet, O., Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Khaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., Koffi N'Goran, B., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K., Louis, R., Macnee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Scholl, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D., Price, D., Rabe, K. F., Raciborski, F., Radier Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez Manas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, J., Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Van Ganse, E., Van Hage, M., Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, G., Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.
Subjects: Pulmonary and Respiratory Medicine, Immunology, Immunology and Allergy
Abstract: 7 1
Published: 2017

21. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis â A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement

Author: Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal-Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V. J., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, Jean, ARIA and EPOS working groups, Akdis, M., Alobid, I., Ankri, J., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Asarnoj, A., Avolio, F., Baiardini, I., Barbagallo, Carlo M., Barbara, Cristina, Baroody, F., Bateman, E. D., Bedbrook, Anna, Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Bergmann, K. C., Bewick, M., Białoszewski, A. Z., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Bucca, C., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Camargos, P. A. M., Camuzat, Thierry, Cardona, V., Carlsen, K. H., Carr, W., Carreiro-Martins, P., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Cervin, A., Cesari, M., Chatzi, L., Chavannes, Niels H., Chiron, R., Pérez, T. Chivato, Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cohen, N., Diaz, S. Conzález, Cox, L., Crooks, George, Cruz, A. A., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Keenoy, E. De Manuel, Sousa, J. Correia de, Vries, Elisabeth G. E. de, Dedeu, Antoni, Deleanu, D., Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H. B., Douglas, R., Dray, G., Toit, G. Du, Dubakiene, R., Durham, S. R., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A., Fiocchi, A., Fletcher, M., Fonseca, J. A., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioǧlu, B., Georgalas, C., Gereda, J. E., Goossens, H., Grisle, I., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Harvey, R., Heinrich, J., Hellquist-Dahl, B., Hopkins, C., Horak, F., Hourihane, J. O. B., Humbert, M., Hyland, M. E., Iaccarino, G., Illario, M., Jares, E. J., Jeandel, Claude, Johnston, S. L., Jonquet, Olivier, Jung, K. S., Just, J., Jutel, M., Kaidashev, I. P., Kalayci, O., Kalogjera, L., Kalyoncu, A. F., Kardas, P., Keil, T., Keith, P. K., Kerkhof, M., Kern, B., Kerstjens, H. A. M., Khaitov, M. R., Khaltaev, N., Klimek, L., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Larenas-Linnemann, D., Lau, S., Laune, D., Le, Tuyen D., Li, J., Lieberman, P., Lipworth, B. J., Carlsen, K. C. Lodrup, Louis, R., Lupinek, C., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P. J., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Mercier, Jacques, Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Almeida, M. Morais, Mosges, R., Mullol, J., Murray, R., Naclerio, R. N., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Nieto, A., Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Papi, A., Park, H. S., Passalacqua, G., Pawankar, R., Pedersen, S., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D. S., Potter, P., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Riechelmann, H., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rottem, M., Ryan, D., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schlosser, R., Schmid-Grendelmeier, P., Schunemann, H. J., Scichilone, N., Senior, B., Serrano, E., Sheikh, A., Shields, K. M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stellato, C., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, Jordi, Thijs, C., Thomas, M., Todo-Bom, A., Tomazic, P. V., Toskala, E., Triggiani, M., Valenta, R., Valero, A. L., Valiulis, A., Valovirta, E., Eerd, M. van, Ganse, E. van, Hage, M. van, Wick, R. G. van, Vandenplas, O., Varona, L. L., Vazankari, T., Vellas, B., Ventura, M. T., Vezzani, G., Viegi, Giovanni, Voegels, R., Vontetsianos, T., Wagenmann, M., Wahn, U., Walker, S., Wang, D. Y., Wang, Ya Xing, Werfel, T., Whalley, B., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wormald, P. J., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yorgancioglu, A., Young, I., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Adult Psychiatry, Ear, Nose and Throat, AII - Inflammatory diseases, AII - Amsterdam institute for Infection and Immunity, Pulmonology, Other departments, Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal-Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, J., Aberer, W., Akdis, M., Alobid, I., Ankri, J., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Asarnoj, A., Avolio, F., Baiardini, I., Barbagallo, M., Barbara, C., Baroody, F., Bateman, E. D., Bedbrook, A., Beghe, B., Bel, E. H., Bennoor, K. S., Benson, M., Bergmann, K. C., Bewick, M., Bialoszewski, A. Z., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Camargos, P. A., Camuzat, T., Cardona, V., Carlsen, K. H., Carr, W., Carreiro-Martins, P., Carriazo, A. M., Casale, T., Cepeda Sarabia, A. M., Cervin, A., Cesari, M., Chatzi, L., Chavannes, N. H., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., Cohen, N., Conzalez Diaz, S., Cox, L., Crooks, G., Cruz, A. A., Custovic, A., Dahl, R., Dahlen, S. E., Darsow, U., De Carlo, G., De Manuel Keenoy, E., de Sousa, J. C., De Vries, G., Dedeu, T., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Douglas, R., Dray, G., Du Toit, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink Wagner, A., Fiocchi, A., Fletcher, M., Fonseca, J., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioglu, B., Georgalas, C., Gereda, J. E., Goossens, H., Grisle, I., Guldemond, N. A., Gutter, Z., Guzman, M. A., Haahtela, T., Harvey, R., Heinrich, J., Hellquist-Dahl, B., Hopkins, C., Horak, F., Hourihane, J. O., Humbert, M., Hyland, M., Iaccarino, G., Illario, M., Jares, E. J., Jeandel, C., Johnston, S. L., Jonquet, O., Jung, K. S., Just, J., Jutel, M., Kaidashev, I. P., Kalayci, O., Kalogjera, L., Kalyoncu, A. F., Kardas, P., Keil, T., Keith, P. K., Kerkhof, M., Kern, B., Kerstjens, H. A., Khaitov, M., Khaltaev, N., Klimek, L., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Larenas-Linnemann, D., Lau, S., Laune, D., Le, L. T., Li, J., Lieberman, P., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lund, V. J., Lupinek, C., Macnee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Morais-Almeida, M., Mosges, R., Mullol, J., Murray, R., Naclerio, R., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Nieto, A., Nogues, M., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Papi, A., Park, H. S., Passalacqua, G., Niggemann, B., Nogueira-Silva, L., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Riechelmann, H., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rodriguez-Manas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schlosser, R., Schmid-Grendelmeier, P., Schunemann, H. J., Scichilone, N., Senior, B., Serrano, E., Sheikh, A., Shields, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stellato, C., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, J., Thijs, C., Thomas, M., Todo-Bom, A., Tomazic, P. V., Toskala, E., Triggiani, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hage, M., van Wick, R. G., Vandenplas, O., Varona, L. L., Vazankari, T., Vellas, B., Ventura, M. T., Vezzani, G., Viegi, G., Voegels, R., Vontetsianos, T., Wagenmann, M., Wahn, U., Walker, S., Wang, D. Y., Wang, Y., Werfel, T., Whalley, B., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wormald, P. J., Wright, J., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Young, I., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Asthma UK, Department of Dermatology, Allergology and Venereology, Clinicum, HUS Inflammation Center, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Hellings, P.W., Fokkens, W.J., Akdis, C.A., Canonica, G.W., Seys, S.F., Ansotegui, I.J., Anto, J.M., Bateman, E.D., Beghé, B., Bel, E.H., Bennoor, K.S., Bergmann, K.C., Bialoszewski, A.Z., Boner, A.L., Boulet, L.P., Bousquet, P.J., Briggs, A.H., Brightling, C.E., Caimmi, D.P., Calderon, M.A., Camargos, P.A., Carlsen, K.H., Carriazo, A.M., Cepeda Sarabia, A.M., Chavannes, N.H., Chuchalin, A.G., Chung, K.F., Conzález Diaz, S., Cruz, A.A., Dahlen, S.E., de Sousa, J.C., Denburg, J.A., Dinh-Xuan, A.T., Durham, S.R., Dykewicz, M.S., Gemicioğlu, B., Gereda, J.E., Guldemond, N.A., Guzmán, M.A., Hourihane, J.O., Jares, E.J., Johnston, S.L., Jung, K.S., Kaidashev, I., Kalyoncu, A.F., Keith, P.K., Kerstjens, H.A., Koppelman, G.H., Kowalski, M.L., Le, L.T., Lodrup Carlsen, K.C., Lund, V.J., MacNee, W., Marshall, G.D., Masjedi, M.R., Melén, E., Meltzer, E.O., Mösges, R., Nyembue, T.D., O'Hehir, R.E., Pali-Schöll, I., Papadopoulos, N.G., Park, H.S., Pawankar, R., Pedersen, S., Pereira, A.M., Popov, T.A., Poulsen, L.K., Rabe, K.F., Rodriguez-Mañas, L., Scadding, G.K., Schunemann, H.J., Simons, F.E.R., Sisul, J.C., Smit, H.A., Solé, D., Sterk, P.J., Tomazic, P.V., van Wick, R.G., Varona, L.L., Ventura, M.T., Wang, D.Y., Williams, D.M., Wormald, P.J., Yawn, B.P., Yiallouros, P.K., Yusuf, O.M., Zar, H.J., and Zernotti, M.E.
Subjects: allergic rhinitis, integrated care pathway, precision medicine, rhinosinusitis, Allergy, Rhinosinusitis, Disease, Allergic rhinitis, 0302 clinical medicine, QUALITY-OF-LIFE, Medicine, Immunology and Allergy, 030223 otorhinolaryngology, Sinusitis, NASAL POLYPOSIS, Rhinitis, Precision medicine, 3. Good health, Algorithm, REAL-LIFE, IMPACT OUTCOMES, ARIA and EPOS working groups, 1107 Immunology, DISEASES, GA(2)LEN, Disease Progression, allergic rhiniti, Life Sciences & Biomedicine, ENDOSCOPIC SINUS SURGERY, Algorithms, Human, Integrated care pathway, Adult, Chronic Disease, Humans, Precision Medicine, Rhinitis, Allergic, Young Adult, Immunology, medicine.medical_specialty, rhinosinusiti, PHENOTYPES, VALIDATION, 03 medical and health sciences, Therapeutic approach, Allergic, Patient satisfaction, Quality of life (healthcare), Patient participation, IMMUNOTHERAPY, Intensive care medicine, Asthma, Science & Technology, business.industry, medicine.disease, Sinusiti, SEVERITY, 030228 respiratory system, 3121 General medicine, internal medicine and other clinical medicine, Physical therapy, ASTHMA, business
Abstract: Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of PM and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of PM within existing adult treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long-term therapeutic strategy. Endotype-driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. 72 9 1297 1305
Published: 2017

22. Однонуклеотидні поліморфізми TLR-2, TLR-3, TLR-4 та сприйнятливість до запальних захворювань дихальних шляхів

Author: Pryimenko, N. O., Kotelevska, T. M., Dubynska, H. M., Kaidashev, I. P., and Pikul, K. V.
Subjects: генотип, воспалительные заболевания верхних и нижних дыхательных путей, полиморфизм Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4, genotype, respiratory tract diseases, Arg753Gln polymorphism of TLR-2 gene, Leu412Phe of TLR-3 gene, Asp299Gly of TLR-4 gene, запальні захворювання верхніх і нижніх дихальних шляхів, поліморфізм Arg753Gln гена TLR-2
Abstract: The aim of the research is to establish an association between Arg753Gln polymorphism of TLR-2 gene, Leu412Phe of TLR-3 gene, Asp299Gly of TLR-4 gene and susceptibility to inflammatory diseases of the upper and lower respiratory tract and the complicated forms of АRI development.Materials and methods. 98 healthy subjects distributed according to the genotype of TLR-2, TLR-3, TLR-4 were enrolled in the study of association between Arg753Gln polymorphism of TLR-2, Leu412Phe of TLR-3 and Asp299Gly of TLR-4 genes and inflammatory diseases of the upper and lower respiratory tract. The polymorphic site of TLR-2 Arg753Gln, TLR-3 Leu412Phe and TLR-4 Asp299Gly genotyping was performed by polymerase chain reaction using oligonucleotide primers. The relative risk of the disease and complications development was estimated using the odds ratio with 95 % confidence interval. The statistical significance of differences in qualitative characteristics was evaluated using Fischer's exact test.Results. It has been revealed that individuals with polymorphic TLR-2, TLR-3 and TLR-4 genes have an increased susceptibility to АRI with frequent episodes during the year that are complicated by lower respiratory tract inflammation as well as chronic inflammatory diseases of the upper respiratory tract. It has been shown that the risk of bronchitis and pneumonia development in АRIs is higher in subjects with polymorphic genotypes of TLR-2, TLR-3 and TLR-4 as compared to the carriers of normal alleles distribution: 2.9 times with Leu/Phe genotype of TLR-3, 20.0 times with Phe/Phe of TLR-3 and 12.8 times with combinations of polymorphic genotypes of TLR-2, TLR-3, TLR-4.Conclusions. The results of the study indicate that the presence of single-nucleotide polymorphisms TLR-2 Arg753Gln, TLR-3 Leu412Phe and TLR-4 Asp299Gly is the marker of high susceptibility to respiratory diseases. Individuals with polymorphic status of TLR-2, TLR-3 and TLR-4 genotypes have an increased susceptibility to inflammatory diseases of the upper and lower respiratory tract with АRI frequency of 4 or more episodes during the year., Цель работы − проследить связь полиморфизма Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4 со склонностью к воспалительным заболеваниям верхних и нижних дыхательных путей и развитием осложненных форм ОРИ.Материалы и методы. Связь полиморфизма генов Arg753Gln TLR-2, Leu412Phe TLR-3, и Asp299Gly TLR-4 с воспалительными заболеваниями верхних и нижних дыхательных путей изучили у 98 практически здоровых лиц, которые были распределены в зависимости от генотипа TLR-2, TLR-3, TLR-4. Генотипирование полиморфного участка Arg753Gln гена TLR-2, Asp299Gly гена TLR-4, Leu412Phe гена TLR-3 проводили методом полимеразной цепной реакции с использованием олигонуклеотидных праймеров. Относительный риск развития заболевания и осложнений оценивали с помощью показателя отношения шансов с доверительным интервалом 95 %. Статистическую значимость различий для качественных признаков оценивали с использованием точного теста Фишера.Результаты. Установлено, что лица с полиморфно измененными генотипами TLR-2, TLR-3, TLR-4 имеют повышенную склонность к ОРИ с частыми эпизодами в течение года, которые осложняются воспалительными процессами нижних дыхательных путей, а также к хроническим воспалительным заболеваниям верхних дыхательных путей. Доказано, что риск развития бронхита и пневмонии при ОРИ выше у лиц с полиморфно измененными генотипами TLR-2, TLR-3, TLR-4 по сравнению с носителями нормального распределения аллелей: с генотипом Leu/Phe TLR-3 − в 2,9, Phe/Phe TLR-3 − в 20,0, комбинациями полиморфно измененных генотипов TLR-2, TLR-3, TLR-4 − в 12,8 раза.Выводы. Результаты исследования свидетельствуют, что маркером высокой восприимчивости к респираторным заболеваниям является наличие однонуклеотидных полиморфизмов Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4. Лица с полиморфно измененными генотипами TLR-2, TLR-3, TLR-4 имеют повышенную склонность к воспалительным заболеваниям верхних и нижних дыхательных путей, ОРИ с частотой эпизодов 4 и более в течение года., Мета роботи – простежити зв’язок поліморфізму Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4 зі схильністю до запальних захворювань верхніх і нижніх дихальних шляхів і розвитком ускладнених форм ГРІ. Матеріали та методи. Зв’язок поліморфізму генів Arg753Gln TLR-2, Leu412Phe TLR-3, та Asp299Gly TLR-4 із запальними захворюваннями верхніх і нижніх дихальних шляхів вивчили у 98 практично здорових осіб, яких поділили залежно від генотипу TLR-2, TLR-3, TLR-4. Генотипування поліморфної ділянки Arg753Gln гена TLR-2, Asp299Gly гена TLR-4, Leu412Phe гена TLR-3 здійснили методом полімеразної ланцюгової реакції з використанням олігонуклеотидних праймерів. Відносний ризик розвитку захворювання та ускладнень оцінювали за допомогою показника відношення шансів із довірчим інтервалом 95 %. Статистичну значущість відмінностей для якісних ознак оцінювали з використанням точного тесту Фішера.Результати. Встановили, що особи з поліморфно зміненими генотипами TLR-2, TLR-3, TLR-4 мають підвищену схильність до ГРІ з частими епізодами протягом року, які ускладнюються запальними процесами нижніх дихальних шляхів, а також до хронічних запальних захворювань верхніх дихальних шляхів. Доведено, що ризик розвитку бронхіту та пневмонії при ГРІ вищий в осіб із поліморфно зміненими генотипами TLR-2, TLR-3, TLR-4 порівняно з носіями нормального розподілу алелей: з генотипом Leu/Phe TLR-3 ‒ у 2,9, Phe/Phe TLR-3 – у 20,0, комбінаціями поліморфно змінених генотипів TLR-2, TLR-3, TLR-4 – у 12,8 раза.Висновки. Результати дослідження свідчать, що маркером високої сприйнятливості до респіраторних захворювань є наявність однонуклеотидних поліморфізмів Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4. Особи з поліморфно зміненими генотипами TLR-2, TLR-3, TLR-4 мають підвищену схильність до запальних захворювань верхніх і нижніх дихальних шляхів, ГРІ з частотою епізодів 4 і більше протягом року.
Published: 2018

23. THE IMPACT OF OBESITY ON THE COURSE OF IRON DEFICIENCY ANEMIA IN WOMEN AND ASSESSMENT OF THEIR QUALITY OF LIFE

Author: Nedoborenko, V. M., primary and Kaidashev, I. P., additional
Published: 2019
Full Text: View/download PDF

24. Contribution of macrophage subpopulations to the pathogenesis of chronic periodontitis in humans and perspectives for study. Review of the literature

Author: Shynkevych, V. I., primary and Kaidashev, I. P., additional
Published: 2019
Full Text: View/download PDF

25. Однонуклеотидні поліморфізми TLR-2, TLR-3, TLR-4 та сприйнятливість до запальних захворювань дихальних шляхів

Author: Pryimenko, N. O.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Kotelevska, T. M.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Dubynska, H. M.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Kaidashev, I. P.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Pikul, K. V.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Pryimenko, N. O.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Kotelevska, T. M.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Dubynska, H. M.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Kaidashev, I. P.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, and Pikul, K. V.; Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava
Abstract: Мета роботи – простежити зв’язок поліморфізму Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4 зі схильністю до запальних захворювань верхніх і нижніх дихальних шляхів і розвитком ускладнених форм ГРІ. Матеріали та методи. Зв’язок поліморфізму генів Arg753Gln TLR-2, Leu412Phe TLR-3, та Asp299Gly TLR-4 із запальними захворюваннями верхніх і нижніх дихальних шляхів вивчили у 98 практично здорових осіб, яких поділили залежно від генотипу TLR-2, TLR-3, TLR-4. Генотипування поліморфної ділянки Arg753Gln гена TLR-2, Asp299Gly гена TLR-4, Leu412Phe гена TLR-3 здійснили методом полімеразної ланцюгової реакції з використанням олігонуклеотидних праймерів. Відносний ризик розвитку захворювання та ускладнень оцінювали за допомогою показника відношення шансів із довірчим інтервалом 95 %. Статистичну значущість відмінностей для якісних ознак оцінювали з використанням точного тесту Фішера.Результати. Встановили, що особи з поліморфно зміненими генотипами TLR-2, TLR-3, TLR-4 мають підвищену схильність до ГРІ з частими епізодами протягом року, які ускладнюються запальними процесами нижніх дихальних шляхів, а також до хронічних запальних захворювань верхніх дихальних шляхів. Доведено, що ризик розвитку бронхіту та пневмонії при ГРІ вищий в осіб із поліморфно зміненими генотипами TLR-2, TLR-3, TLR-4 порівняно з носіями нормального розподілу алелей: з генотипом Leu/Phe TLR-3 ‒ у 2,9, Phe/Phe TLR-3 – у 20,0, комбінаціями поліморфно змінених генотипів TLR-2, TLR-3, TLR-4 – у 12,8 раза.Висновки. Результати дослідження свідчать, що маркером високої сприйнятливості до респіраторних захворювань є наявність однонуклеотидних поліморфізмів Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4. Особи з поліморфно зміненими генотипами TLR-2, TLR-3, TLR-4 мають підвищену схильність до запальних захворювань верхніх і нижніх дихальних шляхів, ГРІ з частотою епізодів 4 і більше протягом року., The aim of the research is to establish an association between Arg753Gln polymorphism of TLR-2 gene, Leu412Phe of TLR-3 gene, Asp299Gly of TLR-4 gene and susceptibility to inflammatory diseases of the upper and lower respiratory tract and the complicated forms of АRI development.Materials and methods. 98 healthy subjects distributed according to the genotype of TLR-2, TLR-3, TLR-4 were enrolled in the study of association between Arg753Gln polymorphism of TLR-2, Leu412Phe of TLR-3 and Asp299Gly of TLR-4 genes and inflammatory diseases of the upper and lower respiratory tract. The polymorphic site of TLR-2 Arg753Gln, TLR-3 Leu412Phe and TLR-4 Asp299Gly genotyping was performed by polymerase chain reaction using oligonucleotide primers. The relative risk of the disease and complications development was estimated using the odds ratio with 95 % confidence interval. The statistical significance of differences in qualitative characteristics was evaluated using Fischer's exact test.Results. It has been revealed that individuals with polymorphic TLR-2, TLR-3 and TLR-4 genes have an increased susceptibility to АRI with frequent episodes during the year that are complicated by lower respiratory tract inflammation as well as chronic inflammatory diseases of the upper respiratory tract. It has been shown that the risk of bronchitis and pneumonia development in АRIs is higher in subjects with polymorphic genotypes of TLR-2, TLR-3 and TLR-4 as compared to the carriers of normal alleles distribution: 2.9 times with Leu/Phe genotype of TLR-3, 20.0 times with Phe/Phe of TLR-3 and 12.8 times with combinations of polymorphic genotypes of TLR-2, TLR-3, TLR-4.Conclusions. The results of the study indicate that the presence of single-nucleotide polymorphisms TLR-2 Arg753Gln, TLR-3 Leu412Phe and TLR-4 Asp299Gly is the marker of high susceptibility to respiratory diseases. Individuals with polymorphic status of TLR-2, TLR-3 and TLR-4 genotypes have an increased susceptibility to inflammato, Цель работы − проследить связь полиморфизма Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4 со склонностью к воспалительным заболеваниям верхних и нижних дыхательных путей и развитием осложненных форм ОРИ.Материалы и методы. Связь полиморфизма генов Arg753Gln TLR-2, Leu412Phe TLR-3, и Asp299Gly TLR-4 с воспалительными заболеваниями верхних и нижних дыхательных путей изучили у 98 практически здоровых лиц, которые были распределены в зависимости от генотипа TLR-2, TLR-3, TLR-4. Генотипирование полиморфного участка Arg753Gln гена TLR-2, Asp299Gly гена TLR-4, Leu412Phe гена TLR-3 проводили методом полимеразной цепной реакции с использованием олигонуклеотидных праймеров. Относительный риск развития заболевания и осложнений оценивали с помощью показателя отношения шансов с доверительным интервалом 95 %. Статистическую значимость различий для качественных признаков оценивали с использованием точного теста Фишера.Результаты. Установлено, что лица с полиморфно измененными генотипами TLR-2, TLR-3, TLR-4 имеют повышенную склонность к ОРИ с частыми эпизодами в течение года, которые осложняются воспалительными процессами нижних дыхательных путей, а также к хроническим воспалительным заболеваниям верхних дыхательных путей. Доказано, что риск развития бронхита и пневмонии при ОРИ выше у лиц с полиморфно измененными генотипами TLR-2, TLR-3, TLR-4 по сравнению с носителями нормального распределения аллелей: с генотипом Leu/Phe TLR-3 − в 2,9, Phe/Phe TLR-3 − в 20,0, комбинациями полиморфно измененных генотипов TLR-2, TLR-3, TLR-4 − в 12,8 раза.Выводы. Результаты исследования свидетельствуют, что маркером высокой восприимчивости к респираторным заболеваниям является наличие однонуклеотидных полиморфизмов Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4. Лица с полиморфно измененными генотипами TLR-2, TLR-3, TLR-4 имеют повышенную склонность к воспалительным заболеваниям верхних и нижних дыхательных путей, ОРИ с частотой эпизодов 4 и более в течение год
Published: 2018

26. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (vol 6, 29, 2016)

Author: Bousquet, Jean, Farrell, J., Crooks, George, Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, Niels H., Sousa, J. Correia de, Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, Anna, Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Kheder, A. Ben, Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, Thierry, Carlsen, K. H., Carr, W., Carriazo, A. M., Casale, T. B., Sarabia, A. C., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, David J., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Blay, F. De, Dedeu, Antoni, Deleanu, D., Keenoy, E. De Manuel, Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H. B., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, Leonardo M., Fletcher, M., Fiocchi, A., Wagner, A. Fink, Fonseca, J. A., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, Judith, Gemicioǧlu, B., Gereda, J. E., Diaz, S. Gonzalez, Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, Claude, Jenkins, C., Johnston, S. L., Jonquet, Olivier, Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Khaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, Tuyen D., Lieberman, P., Lipworth, B. J., Li, J., Carlsen, K. Lodrup, Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P. J., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R. N., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D. S., Price, D., Rabe, K. F., Raciborski, F., Pontal, F. Radier, Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Manas, L. Rodriguez, Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, K. M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, Jordi, Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Ganse, E. Van, Hage, M. van, Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, Jacques, Ear, Nose and Throat, Pulmonology, Yiallouros, Panayiotis K. [0000-0002-8339-9285], and Custovic, Adnan [0000-0001-5218-7071]
Abstract: [This corrects the article DOI: 10.1186/s13601-016-0116-9.]
Published: 2017

27. Single nucleotide polymorphisms of TLR-2, TLR-3, TLR-4 and susceptibility to inflammatory diseases of the respiratory tract

Author: Pryimenko, N. O., primary, Kotelevska, T. M., additional, Dubynska, H. M., additional, Kaidashev, I. P., additional, and Pikul, K. V., additional
Published: 2018
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28. OPTIMIZATION OF TREATMENT OF PATIENTS WITH INSULIN RESISTANCE TO REDUCE THE EXPRESSIVENESS OF CARDIOVASCULAR RISK FACTORS

Author: Vynnyk, N. I., primary, Lavrenko, A.V., additional, Kaidashev, I. P., additional, and Shaienko, Z. О., additional
Published: 2018
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29. MODERN VIEWS OF THE IMMUNOPATHOGENESIS OF PSORIASIS DISEASE

Author: Yemchenko, Ya. O., primary, Ishcheykin, K. E., additional, and Kaidashev, I. P., additional
Published: 2018
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30. CHARACTERISTICS OF CD68 + AND CD163 + INFILTRATION WITH MACROPHAGES OF THE PRIMARY FOCUS AND METASTATIC INJURIES OF REGIONAL LYMPH NODES IN LUMINAL INVASIVE CARCINOMAS OF THE MAMMARY GLAND DEPENDING ON THEIR IMMUNOPHENOTYPE

Author: Aykyan, A. Z., primary, Shynkevych, V. І., additional, and Kaidashev, I. P., additional
Published: 2018
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31. Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA

Author: Bousquet, J, Bewick, M, Cano, A, Eklund, Patrik, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, Bousquet, J, Bewick, M, Cano, A, Eklund, Patrik, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017
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32. Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

Author: UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Vandenplas, O, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Vandenplas, O, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017

33. BUILDING BRIDGES FOR INNOVATION IN AGEING: SYNERGIES BETWEEN ACTION GROUPS OF THE EIP ON AHA

Author: Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Munoz, C., Visser, F., Farrell, J., Malva, J., Ranberg, K. Andersen, Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., Manuel De Keenoy, E., Moda, G., Rodriguez-Manas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Bialoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O'Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guerin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Carlsen, K. C. Lodrup, Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O'Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguiere, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D'Angelantonio, M., De Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougere, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioglu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Heve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezovic, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinaric, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Moesges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., Van Ganse, E., Van Hage, M., Van den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Zagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., De Oliveira-Alves, B., Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Munoz, C., Visser, F., Farrell, J., Malva, J., Ranberg, K. Andersen, Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., Manuel De Keenoy, E., Moda, G., Rodriguez-Manas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Bialoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O'Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guerin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Carlsen, K. C. Lodrup, Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O'Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguiere, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D'Angelantonio, M., De Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougere, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioglu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Heve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezovic, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinaric, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Moesges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., Van Ganse, E., Van Hage, M., Van den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Zagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and De Oliveira-Alves, B.
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017

34. Building Bridges for Innovation in Ageing:Synergies between Action Groups of the EIP on AHA

Author: Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, Holland, Carol Ann, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, and Holland, Carol Ann
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017

35. Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA

Author: CMM USEQ Facility, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, CMM USEQ Facility, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B
Published: 2017

36. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Author: Bousquet, Jean, Schunemann, H. J., Hellings, P. W., Arnavielhe, S., Bachert, C., Bedbrook, Anna, Bergmann, K. C., Bosnic-Anticevitch, S., Brozek, J. L., Calderon, M. A., Canonica, G. W., Casale, T. B., Chavannes, Niels H., Cox, L., Chrystyn, H., Cruz, A. A., Dahl, R., Carlo, G. De, Demoly, Pascal, Devillier, P., Dray, G., Fletcher, M., Fokkens, W. J., Fonseca, J. A., Gonzalez-Diaz, S. N., Grouse, L., Keil, T., Kuna, P., Larenas-Linnemann, D., Carlsen, K. C. Lodrup, Meltzer, E. O., Mullol, J., Muraro, A., Naclerio, R. N., Palkonen, S., Papadopoulos, N. G., Passalacqua, G., Price, D., Ryan, D., Samolinski, B., Scadding, G. K., Sheikh, A., Spertini, F., Valiulis, A., Valovirta, E., Walker, S., Wickman, M., Yorgancioglu, A., Haahtela, T., Zuberbier, T., Aberer, W., Adachi, M., Agache, I., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arshad, S. H., Baiardini, I., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Bel, E. H., Kheder, A. Ben, Bennoor, K. S., Benson, M., Bernstein, D., Michael, B., Thomas, B., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Boner, A. L., Bonini, M., Bonini, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Camargos, P. A. M., Camuzat, Thierry, Carlsen, K. H., Carr, W., Sarabia, A. C., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Ciprandi, G., Cirule, I., Correia-Da-Sousa, J., Costa, David J., Crooks, George, Custovic, Adnan, Dahlen, S. E., Darsow, U., Blay, F. De, Keenoy, E. De Manuel, Dedeu, Antoni, Deleanu, D., Denburg, J. A., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H. B., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fink-Wagner, A., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioǧlu, B., Gereda, J. E., Wijk, R. Gerth van, Gotua, M., Grisle, I., Guzmán, M. A., Heinrich, J., Hellquist-Dahl, B., Horak, F., Howarth, P. H., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Jonquet, Olivier, Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keith, P. K., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kvedariene, V., Lambrecht, B., Lau, S., Laune, D., Tuyet, L. Le Thi, Li, J., Lieberman, P., Lipworth, B. J., Renaud, L., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P. J., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Mercier, Jacques, Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Mosges, R., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Neou, A., Niggemann, B., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Postma, D. S., Potter, P., Poulsen, L. K., Rabe, K. F., Raciborski, F., Pontal, F. Radier, Reitamo, S., Repka-Ramirez, S., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Schmid-Grendelmeier, P., Serrano, E., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, Jordi, Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Hage, M. van, Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Wagenmann, M., Wahn, U., Yun, W. De, Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Clau, Bedbrook, Anna, Bergmann, Karl Christian, Bosnic Anticevich, Sinthia, Brozek, Jan, Calderon, Moise, Canonica, G. Walter, Casale, Thomas B., Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Alvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao, Gonzalez Diaz, Sandra N., Grouse, Lawrence, Keil, Thoma, Kuna, Piotr, Larenas Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, Eli O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Valiulis, Aruna, Valovirta, Erkka, Walker, Samantha, Wickman, Magnu, Yorgancioglu, Arzu, Zuberbier, Torsten, Bonini, Sergio, Ear, Nose and Throat, Pulmonology, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, Clinicum, and Department of Dermatology, Allergology and Venereology
Subjects: Allergy, FUROATE NASAL SPRAY, Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, Review, Clinical decision support system, Allergic rhinitis, DOUBLE-BLIND, 0302 clinical medicine, QUALITY-OF-LIFE, Health care, Medicine and Health Sciences, conjunctivitis, Medicine, Immunology and Allergy, 030212 general & internal medicine, Allergic Rhinitis and its Impact on Asthma, MACVIA-LR, clinical decision support system, information and communication technology, Disease management (health), Rhinitis, Conjunctivitis, Allergic, Allergic Rhinitis And Its Impact On Asthma, Allergic Rhinitis, Macvia-lr, Clinical Decision Support System, Conjunctivitis, Information And Communication Technology, IMPORTANT DIFFERENCE, Adolescent, Adult, Age Factors, Algorithms, Clinical Decision-Making, Disease Management, Humans, Patient Satisfaction, Rhinitis, Allergic, Immunology, Minimal clinically important difference, PRIMARY-CARE, INTRANASAL THERAPY, 1107 Immunology, Information and communication technology, Algorithm, POSITION PAPER, Conjuctivitis, Allergic rhinitis and its impact on asthma, Socio-culturale, OCULAR SYMPTOMS, 03 medical and health sciences, Patient satisfaction, Quality of life (healthcare), Pharmacotherapy, Allergic, MASK study group, Allergic rhiniti, Journal Article, business.industry, MOMETASONE FUROATE, Conjunctiviti, ta3121, medicine.disease, 030228 respiratory system, 3121 General medicine, internal medicine and other clinical medicine, VISUAL ANALOG SCALE, business
Abstract: The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR [fighting chronic diseases for active and healthy ageing]), one of the reference sites of the European Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the MACVIA-ARIA Sentinel Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials. ispartof: Journal of Allergy and Clinical Immunology vol:138 issue:2 pages:367-+ ispartof: location:United States status: published
Published: 2016

37. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author: Bousquet, Jean, Farrell, J., Crooks, George, Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, Niels H., Sousa, J. Correia de, Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, Anna, Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Kheder, A. B., Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, Thierry, Carlsen, K. H., Carr, W., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, David J., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Blay, F. De, Dedeu, Antoni, Deleanu, D., Keenoy, E. De Manuel, Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H. B., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, Leonardo M., Fletcher, M., Fiocchi, A., Fink-Wagner, A., Fonseca, J. A., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, Judith, Gemicioǧlu, B., Gereda, J. E., Diaz, S. González, Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, Claude, Jenkins, C., Johnston, S. L., Jonquet, Olivier, Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Kaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, Tuyen D., Lieberman, P., Lipworth, B. J., Li, J., Carlsen, K. C. Lodrup, Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P. J., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R. N., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D. S., Price, D., Rabe, K. F., Raciborski, F., Radier-Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, K. M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, Jordi, Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Ganse, E. Van, Hage, M. van, Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, Jacques, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E. H, Bewick, M, Chavannes, N. H, de Sousa, J. Correia, Cruz, A. A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C. A, Akdis, M, Ankri, J, Alonso, A, Annesi Maesano, I, Ansotegui, I. J, Anto, J. M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A. K, Barbara, C, Bateman, E. D, Beghé, B, Kheder, A. Ben, Bennoor, K. S, Benson, M, Bergmann, K. C, Bieber, T, Bindslev Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A. L, Bonini, M, Bonini, Sergio, Bosnic Anticevitch, S, Boulet, L. P, Bourret, R, Bousquet, P. J, Braido, F, Briggs, A. H, Brightling, C. E, Brozek, J, Buhl, R, Burney, P. G, Bush, A, Caballero Fonseca, F, Caimmi, D, Calderon, M. A, Calverley, P. M, Camargos, P. A. M, Canonica, G. W, Camuzat, T, Carlsen, K. H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A. M, Chatzi, L, Chen, Y. Z, Chiron, R, Chkhartishvili, E, Chuchalin, A. G, Chung, K. F, Ciprandi, G, Cirule, I, Cox, L, Costa, D. J, Custovic, A, Dahl, R, Dahlen, S. E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J. A, Devillier, P, Didier, A, Dinh Xuan, A. T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S. R, Dykewicz, M. S, El Gamal, Y, Emuzyte, R, Fabbri, L. M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W. J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia Aymerich, J, Gemicioğlu, B, Gereda, J. E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M. A, Heaney, L. G, Hellquist Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J. O' B, Howarth, P, Humbert, M, Hyland, M. E, Illario, M, Ivancevich, J. C, Jardim, J. R, Jares, E. J, Jeandel, C, Jenkins, C, Johnston, S. L, Jonquet, O, Julge, K, Jung, K. S, Just, J, Kaidashev, I, Kaitov, M. R, Kalayci, O, Kalyoncu, A. F, Keil, T, Keith, P. K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G. H, Kowalski, M. L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas Linnemann, D, Laune, D, Le, L. T. T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, Macnee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M. J, Manning, P, Mara, S, Marshall, G. D, Masjedi, M. R, Matignon, P, Maurer, M, Mavale Manuel, S, Melén, E, Melo Gomes, E, Meltzer, E. O, Menzies Gow, A, Merk, H, Michel, J. P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G. M. Y, Molimard, M, Momas, I, Montilla Santana, A, Morais Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T. D, O'Hehir, R. E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H. S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T. A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K. F, Raciborski, F, Radier Pontal, F, Repka Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez Borges, M, Scadding, G. K, Schunemann, H. J, Serrano, E, Schmid Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F. E. R, Sisul, J. C, Skrindo, I, Smit, H. A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P. J, Sunyer, J, Thijs, C, To, T, Todo Bom, A, Triggiani, M, Valenta, R, Valero, A. L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D. Y, Wahn, U, Wickman, M, Williams, D. M, Williams, S, Wright, J, Yawn, B. P, Yiallouros, P. K, Yusuf, O. M, Zaidi, A, Zar, H. J, Zernotti, M. E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J., Clinicum, Department of Dermatology, Allergology and Venereology, Department of Medicine, Timo Strandberg / Principal Investigator, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Department of Paediatrics and Child Health, Faculty of Health Sciences, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Bonini, S, Illario, Maddalena, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Çocuk Sağlığı ve Hastalıkları, Department of Physics, Faculty of Science, and Universidade do Minho
Subjects: Pulmons -- Malalties obstructives, Veterinary medicine, Allergy, Published Erratum, LANGUEDOC-ROUSSILLON, Respiratory Medicine and Allergy, [SDV]Life Sciences [q-bio], Aparell respiratori -- Malalties, OPERATIONAL DEFINITION, Alternative medicine, Review, Chronic respiratory diseases, GLOBAL ALLIANCE, SYSTEMS MEDICINE, 0302 clinical medicine, Medicine and Health Sciences, Immunology and Allergy, MACVIA, 030212 general & internal medicine, AIRWAYS ICP, Lungmedicin och allergi, EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, AIRWAYS ICPs, ARIA, Scaling up, GINA STRATEGY, AIRWAYS, UPDATE ARIA 2008, Respiratory disease, Outras Ciências Agrárias [Ciências Agrárias], 3. Good health, Chronic respiratory disease, ALLERGIC RHINITIS, ICPs, General partnership, Action plan, Erratum, Life Sciences & Biomedicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Emerging technologies, Immunology, REFERENCE SITE, Socio-culturale, Predictive medicine, 03 medical and health sciences, Nursing, Critical success factor, Journal Article, medicine, ddc:610, Science & Technology, business.industry, Settore MED/09 - MEDICINA INTERNA, AIRWAYS-ICPS, medicine.disease, Integrated care, Alliance, 030228 respiratory system, Ciências Agrárias::Outras Ciências Agrárias, 3121 General medicine, internal medicine and other clinical medicine, Family medicine, Healthy ageing, business, SEVERE ASTHMA
Abstract: Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing. Electronic supplementary material The online version of this article (doi:10.1186/s13601-016-0116-9) contains supplementary material, which is available to authorized users.
Published: 2016

38. WITHDRAWN: Scaling up strategies of the Chronic Respiratory Disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 – Area 5)

Author: Bousquet, J., Farrell, J., Crooks, G., Hellings, P., Bel, E.H., Bewick, M., Chavannes, N.H., Correia de Sousa, J., Cruz, A.A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, A., Aberer, W., Adachi, M., Agusti, A., Akdis, C.A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I.J., Anto, J.M., Arnavielhe, S., Arshad, H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A.K., Barbara, C., Bateman, E.D., Beghé, B., Ben Kheder, A., Bennoor, K.S., Benson, M., Bergmann, K.C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A.L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L.P., Bourret, R., Bousquet, P.J., Braido, F., Briggs, A.H., Brightling, C.E., Brozek, J., Buhl, R., Burney, P.G., Bush, A., Caballero-Fonseca, F., Caimmi, D., Calderon, M.A., Calverley, P.M., Camargos, P.A.M., Canonica, G.W., Camuzat, T., Carlsen, K.H., Carr, W., Carriazo, A., Casale, T., Cepeda Sarabia, A.M., Chatzi, L., Chen, Y.Z., Chiron, R., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G., Cirule, I., Cox, L., Costa, D.J., Custovic, A., Dahl, R., Dahlen, S.E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., De Manuel Keenoy, E., Demoly, P., Denburg, J.A., Devillier, P., Didier, A., Dinh-Xuan, A.T., Djukanovic, R., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S.R., Dykewicz, M.S., El-Gamal, Y., Emuzyte, R., Fabbri, L.M., Fletcher, M., Fiocchi, A., Fink Wagner, A., Fonseca, J., Fokkens, W.J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, J., Gemicioğlu, B., Gereda, J.E., González Diaz, S., Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A., Heaney, L.G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J.O’B., Howarth, P., Humbert, M., Hyland, M.E., Illario, M., Ivancevich, J.C., Jardim, J.R., Jares, E.J., Jeandel, C., Jenkins, C., Johnston, S.L., Jonquet, O., Julge, K., Jung, K.S., Just, J., Kaidashev, I., Kaitov, M.R., Kalayci, O., Kalyoncu, A.F., Keil, T., Keith, P.K., Klimek, L., Koffi N’Goran, B., Kolek, V., Koppelman, G.H., Kowalski, M.L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L.T.T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K., Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M.J., Manning, P., Mara, S., Marshall, G.D., Masjedi, M.R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E.O., Menzies-Gow, A., Merk, H., Michel, J.P., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda Y. Mohammad, G., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Morgan, M., Mösges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T.D., O’Hehir, R.E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H.S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T.A., Portejoie, F., Potter, P., Postma, D., Price, D., Rabe, K.F., Raciborski, F., Radier Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez Mañas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G.K., Schunemann, H.J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F.E.R., Sisul, J.C., Skrindo, I., Smit, H.A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J., Sunyer, J., Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A.L., Valia, E., Valovirta, E., Van Ganse, E., van Hage, M., Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, G., Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D.Y., Wahn, U., Wickman, M., Williams, D.M., Williams, S., Wright, J., Yawn, B.P., Yiallouros, P.K., Yusuf, O.M., Zaidi, A., Zar, H.J., Zernotti, M.E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.
Abstract: This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
Published: 2024
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39. Erratum to: Building bridges for innovation in ageing:Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., de Oliveira-Alves, B., Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2016

40. Erratum to: Building bridges for innovation in ageing : Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., de Oliveira-Alves, B., Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2016

41. ARIA 2016:Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J., Hellings, P. W., Agache, I., Bedbrook, A., Bachert, C., Bergmann, K. C., Bewick, M., Bindslev-Jensen, C., Bosnic-Anticevitch, S., Bucca, C., Caimmi, D. P., Camargos, P. A.M., Canonica, G. W., Casale, T., Chavannes, N. H., Cruz, A. A., De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W. J., Guldemond, N. A., Haahtela, T., Illario, M., Just, J., Keil, T., Klimek, L., Kuna, P., Larenas-Linnemann, D., Morais-Almeida, M., Mullol, J., Murray, R., Naclerio, R., O'Hehir, R. E., Papadopoulos, N. G., Pawankar, R., Potter, P., Ryan, D., Samolinski, B., Schunemann, H. J., Sheikh, A., Simons, F. E.R., Stellato, C., Todo-Bom, A., Tomazic, P. V., Valiulis, A., Valovirta, E., Ventura, M. T., Wickman, M., Young, I., Yorgancioglu, A., Zuberbier, T., Aberer, W., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ankri, J., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I., Barbara, C., Barbagallo, M., Bateman, E. D., Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Białoszewski, A. Z., Bieber, T., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camuzat, T., Cardona, V., Carreiro-Martins, P., Carriazo, A. M., Carlsen, K. H., Carr, W., Cepeda Sarabia, A. M., Cesari, M., Chatzi, L., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., De Sousa, J. Correia, Cox, L., Crooks, G., Custovic, A., Dahlen, S. E., Darsow, U., Dedeu, T., Deleanu, D., Denburg, J. A., De Vries, G., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink Wagner, A., Fiocchi, A., Fletcher, M., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioǧlu, B., Gereda, J. E., Van Wick, R. Gerth, González Diaz, S., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E. J., Jeandel, C., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Kardas, P., Keith, P. K., Kerkhof, M., Kerstjens, H. A.M., Khaltaev, N., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kuitunen, M., Kull, I., Kvedariene, V., Lambrecht, B., Lau, S., Laune, D., Le, L. T.T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K. C., Louis, R., Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Mösges, R., Muraro, A., Namazova-Baranova, L., Nadif, R., Neffen, H., Nekam, K., Nieto, A., Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T. D., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Palkonen, S., Panzner, P., Papi, A., Park, H. S., Passalacqua, G., Pedersen, S., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodriguez-Mañas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Scichilone, N., Schmid-Grendelmeier, P., Serrano, E., Shields, M., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, J., Thijs, C., Triggiani, M., Valenta, R., Valero, A., Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O., Varona, L. L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Werfel, T., Whalley, B., Williams, D. M., Williams, S., Wilson, N., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Bousquet, J., Hellings, P. W., Agache, I., Bedbrook, A., Bachert, C., Bergmann, K. C., Bewick, M., Bindslev-Jensen, C., Bosnic-Anticevitch, S., Bucca, C., Caimmi, D. P., Camargos, P. A.M., Canonica, G. W., Casale, T., Chavannes, N. H., Cruz, A. A., De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W. J., Guldemond, N. A., Haahtela, T., Illario, M., Just, J., Keil, T., Klimek, L., Kuna, P., Larenas-Linnemann, D., Morais-Almeida, M., Mullol, J., Murray, R., Naclerio, R., O'Hehir, R. E., Papadopoulos, N. G., Pawankar, R., Potter, P., Ryan, D., Samolinski, B., Schunemann, H. J., Sheikh, A., Simons, F. E.R., Stellato, C., Todo-Bom, A., Tomazic, P. V., Valiulis, A., Valovirta, E., Ventura, M. T., Wickman, M., Young, I., Yorgancioglu, A., Zuberbier, T., Aberer, W., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ankri, J., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I., Barbara, C., Barbagallo, M., Bateman, E. D., Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Białoszewski, A. Z., Bieber, T., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camuzat, T., Cardona, V., Carreiro-Martins, P., Carriazo, A. M., Carlsen, K. H., Carr, W., Cepeda Sarabia, A. M., Cesari, M., Chatzi, L., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., De Sousa, J. Correia, Cox, L., Crooks, G., Custovic, A., Dahlen, S. E., Darsow, U., Dedeu, T., Deleanu, D., Denburg, J. A., De Vries, G., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink Wagner, A., Fiocchi, A., Fletcher, M., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioǧlu, B., Gereda, J. E., Van Wick, R. Gerth, González Diaz, S., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E. J., Jeandel, C., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Kardas, P., Keith, P. K., Kerkhof, M., Kerstjens, H. A.M., Khaltaev, N., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kuitunen, M., Kull, I., Kvedariene, V., Lambrecht, B., Lau, S., Laune, D., Le, L. T.T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K. C., Louis, R., Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Mösges, R., Muraro, A., Namazova-Baranova, L., Nadif, R., Neffen, H., Nekam, K., Nieto, A., Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T. D., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Palkonen, S., Panzner, P., Papi, A., Park, H. S., Passalacqua, G., Pedersen, S., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodriguez-Mañas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Scichilone, N., Schmid-Grendelmeier, P., Serrano, E., Shields, M., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, J., Thijs, C., Triggiani, M., Valenta, R., Valero, A., Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O., Varona, L. L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Werfel, T., Whalley, B., Williams, D. M., Williams, S., Wilson, N., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., and Zidarn, M.
Abstract: The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA - disseminated and implemented in over 70 countries globally - is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.
Published: 2016

42. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Author: Bousquet, J., Schunemann, H. J., Hellings, P. W., Arnavielhe, S., Bachert, C., Bedbrook, A., Bergmann, K. -C., Bosnic-Anticevich, S., Brozek, J., Calderon, M., Canonica, G. W., Casale, T. B., Chavannes, N. H., Cox, L., Chrystyn, H., Cruz, A. A., Dahl, R., De Carlo, G., Demoly, P., Devillier, P., Dray, G., Fletcher, M., Fokkens, W. J., Fonseca, J., Gonzalez-Diaz, S. N., Grouse, L., Keil, T., Kuna, P., Larenas-Linnemann, D., Lodrup Carlsen, K. C., Meltzer, E. O., Mullol, J., Muraro, A., Naclerio, R. N., Palkonen, S., Papadopoulos, N. G., Passalacqua, G., Price, D., Ryan, D., Samolinski, B., Scadding, G. K., Sheikh, A., Spertini, F., Valiulis, A., Valovirta, E., Walker, S., Wickman, M., Yorgancioglu, A., Haahtela, T., Zuberbier, T., Aberer, W., Adachi, M., Agache, I., Akdis, C., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arshad, S. H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bernstein, D., Michael, B., Thomas, B., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A., Bonini, Matteo, Bonini, S., Bosse, I., Bouchard, J., Boulet, L. -P., Bourret, R. A., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Buhl, R., Burney, P., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Camargos, P., Camuzat, T., Carlsen, K. -H., Carr, W., Sarabia, A. C., Chatzi, L., Chen, Y., Chiron, R., Chkhartishvili, E., Chuchalin, A., Ciprandi, G., Cirule, I., Correia de Sousa, J., Costa, D., Crooks, G., Custovic, A., Dahlen, S. -E., Darsow, U., De Blay, F., De Manuel Keenoy, E., Dedeu, T., Deleanu, D., Denburg, J., Didier, A., Dinh-Xuan, A. -T., Dokic, D., Douagui, H. B., Dubakiene, R., Durham, S., Dykewicz, M., El-Gamal, Y., Emuzyte, R., Fink-Wagner, A., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioglu, B., Gereda, J. E., Gerth van Wijk, R., Gotua, M., Grisle, I., Guzman, M. A., Heinrich, J., Hellquist-Dahl, B., Horak, F., Howarth, P. H., Humbert, M., Hyland, M., Ivancevich, J. -C., Jares, E. J., Johnston, S. L., Jonquet, O., Joos, G., Jung, K. -S., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, F., Keith, P., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., N'Goran, B. K., Kolek, V., Koppelman, G. H., Kowalski, M., Kull, I., Kvedariene, V., Lambrecht, B., Lau, S., Laune, D., Le Thi Tuyet, L., Li, J., Lieberman, P., Lipworth, B. J., Renaud, L., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M., Manning, P. J., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Mosges, R., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Neou, A., Niggemann, B., Nyembue, D., O'Hehir, R., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. -L., Pali-Scholl, I., Palmer, S., Panzner, P., Papi, A., Park, H. -S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T., Postma, D. S., Potter, P., Poulsen, L. K., Rabe, K. F., Raciborski, F., Pontal, F. R., Reitamo, S., Repka-Ramirez, M. -S., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rolland, C., Rodriguez, M. R., Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Schmid-Grendelmeier, P., Serrano, E., Simons, F. E. R., Sisul, J. -C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A. -M., Triggiani, M., Valenta, R., Valero, A. L., van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Wahn, U., De Yun, W., Williams, D., Wright, J., Yawn, B. P., Yiallouros, P., Yusuf, O. M., Zar, H. J., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M., Bonini M. (ORCID:0000-0002-3042-0765), Bousquet, J., Schunemann, H. J., Hellings, P. W., Arnavielhe, S., Bachert, C., Bedbrook, A., Bergmann, K. -C., Bosnic-Anticevich, S., Brozek, J., Calderon, M., Canonica, G. W., Casale, T. B., Chavannes, N. H., Cox, L., Chrystyn, H., Cruz, A. A., Dahl, R., De Carlo, G., Demoly, P., Devillier, P., Dray, G., Fletcher, M., Fokkens, W. J., Fonseca, J., Gonzalez-Diaz, S. N., Grouse, L., Keil, T., Kuna, P., Larenas-Linnemann, D., Lodrup Carlsen, K. C., Meltzer, E. O., Mullol, J., Muraro, A., Naclerio, R. N., Palkonen, S., Papadopoulos, N. G., Passalacqua, G., Price, D., Ryan, D., Samolinski, B., Scadding, G. K., Sheikh, A., Spertini, F., Valiulis, A., Valovirta, E., Walker, S., Wickman, M., Yorgancioglu, A., Haahtela, T., Zuberbier, T., Aberer, W., Adachi, M., Agache, I., Akdis, C., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arshad, S. H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bernstein, D., Michael, B., Thomas, B., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A., Bonini, Matteo, Bonini, S., Bosse, I., Bouchard, J., Boulet, L. -P., Bourret, R. A., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Buhl, R., Burney, P., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Camargos, P., Camuzat, T., Carlsen, K. -H., Carr, W., Sarabia, A. C., Chatzi, L., Chen, Y., Chiron, R., Chkhartishvili, E., Chuchalin, A., Ciprandi, G., Cirule, I., Correia de Sousa, J., Costa, D., Crooks, G., Custovic, A., Dahlen, S. -E., Darsow, U., De Blay, F., De Manuel Keenoy, E., Dedeu, T., Deleanu, D., Denburg, J., Didier, A., Dinh-Xuan, A. -T., Dokic, D., Douagui, H. B., Dubakiene, R., Durham, S., Dykewicz, M., El-Gamal, Y., Emuzyte, R., Fink-Wagner, A., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioglu, B., Gereda, J. E., Gerth van Wijk, R., Gotua, M., Grisle, I., Guzman, M. A., Heinrich, J., Hellquist-Dahl, B., Horak, F., Howarth, P. H., Humbert, M., Hyland, M., Ivancevich, J. -C., Jares, E. J., Johnston, S. L., Jonquet, O., Joos, G., Jung, K. -S., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, F., Keith, P., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., N'Goran, B. K., Kolek, V., Koppelman, G. H., Kowalski, M., Kull, I., Kvedariene, V., Lambrecht, B., Lau, S., Laune, D., Le Thi Tuyet, L., Li, J., Lieberman, P., Lipworth, B. J., Renaud, L., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M., Manning, P. J., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Mosges, R., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Neou, A., Niggemann, B., Nyembue, D., O'Hehir, R., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. -L., Pali-Scholl, I., Palmer, S., Panzner, P., Papi, A., Park, H. -S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T., Postma, D. S., Potter, P., Poulsen, L. K., Rabe, K. F., Raciborski, F., Pontal, F. R., Reitamo, S., Repka-Ramirez, M. -S., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rolland, C., Rodriguez, M. R., Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Schmid-Grendelmeier, P., Serrano, E., Simons, F. E. R., Sisul, J. -C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A. -M., Triggiani, M., Valenta, R., Valero, A. L., van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Wahn, U., De Yun, W., Williams, D., Wright, J., Yawn, B. P., Yiallouros, P., Yusuf, O. M., Zar, H. J., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M., and Bonini M. (ORCID:0000-0002-3042-0765)
Abstract: The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR [fighting chronic diseases for active and healthy ageing]), one of the reference sites of the European Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the MACVIA-ARIA Sentinel Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials.
Published: 2016

43. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, primary, Bewick, M., additional, Cano, A., additional, Eklund, P., additional, Fico, G., additional, Goswami, N., additional, Guldemond, N. A., additional, Henderson, D., additional, Hinkema, M. J., additional, Liotta, G., additional, Mair, A., additional, Molloy, W., additional, Monaco, A., additional, Monsonis-Paya, I., additional, Nizinska, A., additional, Papadopoulos, H., additional, Pavlickova, A., additional, Pecorelli, S., additional, Prados-Torres, A., additional, Roller-Wirnsberger, R. E., additional, Somekh, D., additional, Vera-Muñoz, C., additional, Visser, F., additional, Farrell, J., additional, Malva, J., additional, Andersen Ranberg, K., additional, Camuzat, T., additional, Carriazo, A. M., additional, Crooks, G., additional, Gutter, Z., additional, Iaccarino, G., additional, de Keenoy, E. Manuel, additional, Moda, G., additional, Rodriguez-Mañas, L., additional, Vontetsianos, T., additional, Abreu, C., additional, Alonso, J., additional, Alonso-Bouzon, C., additional, Ankri, J., additional, Arredondo, M. T., additional, Avolio, F., additional, Bedbrook, A., additional, Białoszewski, A. Z., additional, Blain, H., additional, Bourret, R., additional, Cabrera-Umpierrez, M. F., additional, Catala, A., additional, O’Caoimh, R., additional, Cesari, M., additional, Chavannes, N. H., additional, Correia-Da-Sousa, J., additional, Dedeu, T., additional, Ferrando, M., additional, Ferri, M., additional, Fokkens, W. J., additional, Garcia-Lizana, F., additional, Guérin, O., additional, Hellings, P. W., additional, Haahtela, T., additional, Illario, M., additional, Inzerilli, M. C., additional, Lodrup Carlsen, K. C., additional, Kardas, P., additional, Keil, T., additional, Maggio, M., additional, Mendez-Zorrilla, A., additional, Menditto, E., additional, Mercier, J., additional, Michel, J. P., additional, Murray, R., additional, Nogues, M., additional, O’Byrne-Maguire, I., additional, Pappa, D., additional, Parent, A. S., additional, Pastorino, M., additional, Robalo-Cordeiro, C., additional, Samolinski, B., additional, Siciliano, P., additional, Teixeira, A. M., additional, Tsartara, S. I., additional, Valiulis, A., additional, Vandenplas, O., additional, Vasankari, T., additional, Vellas, B., additional, Vollenbroek-Hutten, M., additional, Wickman, M., additional, Yorgancioglu, A., additional, Zuberbier, T., additional, Barbagallo, M., additional, Canonica, G. W., additional, Klimek, L., additional, Maggi, S., additional, Aberer, W., additional, Akdis, C., additional, Adcock, I. M., additional, Agache, I., additional, Albera, C., additional, Alonso-Trujillo, F., additional, Angel Guarcia, M., additional, Annesi-Maesano, I., additional, Apostolo, J., additional, Arshad, S. H., additional, Attalin, V., additional, Avignon, A., additional, Bachert, C., additional, Baroni, I., additional, Bel, E., additional, Benson, M., additional, Bescos, C., additional, Blasi, F., additional, Barbara, C., additional, Bergmann, K. C., additional, Bernard, P. L., additional, Bonini, S., additional, Bousquet, P. J., additional, Branchini, B., additional, Brightling, C. E., additional, Bruguière, V., additional, Bunu, C., additional, Bush, A., additional, Caimmi, D. P., additional, Calderon, M. A., additional, Canovas, G., additional, Cardona, V., additional, Carlsen, K. H., additional, Cesario, A., additional, Chkhartishvili, E., additional, Chiron, R., additional, Chivato, T., additional, Chung, K. F., additional, D’Angelantonio, M., additional, de Carlo, G., additional, Cholley, D., additional, Chorin, F., additional, Combe, B., additional, Compas, B., additional, Costa, D. J., additional, Costa, E., additional, Coste, O., additional, Coupet, A. -L., additional, Crepaldi, G., additional, Custovic, A., additional, Dahl, R., additional, Dahlen, S. E., additional, Demoly, P., additional, Devillier, P., additional, Didier, A., additional, Dinh-Xuan, A. T., additional, Djukanovic, R., additional, Dokic, D., additional, du Toit, G., additional, Dubakiene, R., additional, Dupeyron, A., additional, Emuzyte, R., additional, Fiocchi, A., additional, Wagner, A., additional, Fletcher, M., additional, Fonseca, J., additional, Fougère, B., additional, Gamkrelidze, A., additional, Garces, G., additional, Garcia-Aymeric, J., additional, Garcia-Zapirain, B., additional, Gemicioğlu, B., additional, Gouder, C., additional, Hellquist-Dahl, B., additional, Hermosilla-Gimeno, I., additional, Héve, D., additional, Holland, C., additional, Humbert, M., additional, Hyland, M., additional, Johnston, S. L., additional, Just, J., additional, Jutel, M., additional, Kaidashev, I. P., additional, Khaitov, M., additional, Kalayci, O., additional, Kalyoncu, A. F., additional, Keijser, W., additional, Kerstjens, H., additional, Knezović, J., additional, Kowalski, M., additional, Koppelman, G. H., additional, Kotska, T., additional, Kovac, M., additional, Kull, I., additional, Kuna, P., additional, Kvedariene, V., additional, Lepore, V., additional, Macnee, W., additional, Magnan, A., additional, Majer, I., additional, Manning, P., additional, Marcucci, M., additional, Marti, T., additional, Masoli, M., additional, Melen, E., additional, Miculinic, N., additional, Mihaltan, F., additional, Milenkovic, B., additional, Millot-Keurinck, J., additional, Mlinarić, H., additional, Momas, I., additional, Montefort, S., additional, Morais-Almeida, M., additional, Moreno-Casbas, T., additional, Mösges, R., additional, Mullol, J., additional, Nadif, R., additional, Nalin, M., additional, Navarro-Pardo, E., additional, Nekam, K., additional, Ninot, G., additional, Paccard, D., additional, Pais, S., additional, Palummeri, E., additional, Panzner, P., additional, Papadopoulos, N. K., additional, Papanikolaou, C., additional, Passalacqua, G., additional, Pastor, E., additional, Perrot, M., additional, Plavec, D., additional, Popov, T. A., additional, Postma, D. S., additional, Price, D., additional, Raffort, N., additional, Reuzeau, J. C., additional, Robine, J. M., additional, Rodenas, F., additional, Robusto, F., additional, Roche, N., additional, Romano, A., additional, Romano, V., additional, Rosado-Pinto, J., additional, Roubille, F., additional, Ruiz, F., additional, Ryan, D., additional, Salcedo, T., additional, Schmid-Grendelmeier, P., additional, Schulz, H., additional, Schunemann, H. J., additional, Serrano, E., additional, Sheikh, A., additional, Shields, M., additional, Siafakas, N., additional, Scichilone, N., additional, Skrindo, I., additional, Smit, H. A., additional, Sourdet, S., additional, Sousa-Costa, E., additional, Spranger, O., additional, Sooronbaev, T., additional, Sruk, V., additional, Sterk, P. J., additional, Todo-Bom, A., additional, Touchon, J., additional, Tramontano, D., additional, Triggiani, M., additional, Valero, A. L., additional, Valovirta, E., additional, van Ganse, E., additional, van Hage, M., additional, van den Berge, M., additional, Ventura, M. T., additional, Vergara, I., additional, Vezzani, G., additional, Vidal, D., additional, Viegi, G., additional, Wagemann, M., additional, Whalley, B., additional, Wilson, N., additional, Yiallouros, P. K., additional, Žagar, M., additional, Zaidi, A., additional, Zidarn, M., additional, Hoogerwerf, E. J., additional, Usero, J., additional, Zuffada, R., additional, Senn, A., additional, and de Oliveira-Alves, B., additional
Published: 2016
Full Text: View/download PDF

44. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, primary, Bewick, M., additional, Cano, A., additional, Eklund, P., additional, Fico, G., additional, Goswami, N., additional, Guldemond, N. A., additional, Henderson, D., additional, Hinkema, M. J., additional, Liotta, G., additional, Mair, A., additional, Molloy, W., additional, Monaco, A., additional, Monsonis-Paya, I., additional, Nizinska, A., additional, Papadopoulos, H., additional, Pavlickova, A., additional, Pecorelli, S., additional, Prados-Torres, A., additional, Roller-Wirnsberger, R. E., additional, Somekh, D., additional, Vera-Muñoz, C., additional, Visser, F., additional, Farrell, J., additional, Malva, J., additional, Andersen Ranberg, K., additional, Camuzat, T., additional, Carriazo, A. M., additional, Crooks, G., additional, Gutter, Z., additional, Iaccarino, G., additional, de Keenoy, E. Manuel, additional, Moda, G., additional, Rodriguez-Mañas, L., additional, Vontetsianos, T., additional, Abreu, C., additional, Alonso, J., additional, Alonso-Bouzon, C., additional, Ankri, J., additional, Arredondo, M. T., additional, Avolio, F., additional, Bedbrook, A., additional, Białoszewski, A. Z., additional, Blain, H., additional, Bourret, R., additional, Cabrera-Umpierrez, M. F., additional, Catala, A., additional, O’Caoimh, R., additional, Cesari, M., additional, Chavannes, N. H., additional, Correia-Da-Sousa, J., additional, Dedeu, T., additional, Ferrando, M., additional, Ferri, M., additional, Fokkens, W. J., additional, Garcia-Lizana, F., additional, Guérin, O., additional, Hellings, P. W., additional, Haahtela, T., additional, Illario, M., additional, Inzerilli, M. C., additional, Lodrup Carlsen, K. C., additional, Kardas, P., additional, Keil, T., additional, Maggio, M., additional, Mendez-Zorrilla, A., additional, Menditto, E., additional, Mercier, J., additional, Michel, J. P., additional, Murray, R., additional, Nogues, M., additional, O’Byrne-Maguire, I., additional, Pappa, D., additional, Parent, A. S., additional, Pastorino, M., additional, Robalo-Cordeiro, C., additional, Samolinski, B., additional, Siciliano, P., additional, Teixeira, A. M., additional, Tsartara, S. I., additional, Valiulis, A., additional, Vandenplas, O., additional, Vasankari, T., additional, Vellas, B., additional, Vollenbroek-Hutten, M., additional, Wickman, M., additional, Yorgancioglu, A., additional, Zuberbier, T., additional, Barbagallo, M., additional, Canonica, G. W., additional, Klimek, L., additional, Maggi, S., additional, Aberer, W., additional, Akdis, C., additional, Adcock, I. M., additional, Agache, I., additional, Albera, C., additional, Alonso-Trujillo, F., additional, Angel Guarcia, M., additional, Annesi-Maesano, I., additional, Apostolo, J., additional, Arshad, S. H., additional, Attalin, V., additional, Avignon, A., additional, Bachert, C., additional, Baroni, I., additional, Bel, E., additional, Benson, M., additional, Bescos, C., additional, Blasi, F., additional, Barbara, C., additional, Bergmann, K. C., additional, Bernard, P. L., additional, Bonini, S., additional, Bousquet, P. J., additional, Branchini, B., additional, Brightling, C. E., additional, Bruguière, V., additional, Bunu, C., additional, Bush, A., additional, Caimmi, D. P., additional, Calderon, M. A., additional, Canovas, G., additional, Cardona, V., additional, Carlsen, K. H., additional, Cesario, A., additional, Chkhartishvili, E., additional, Chiron, R., additional, Chivato, T., additional, Chung, K. F., additional, D’Angelantonio, M., additional, de Carlo, G., additional, Cholley, D., additional, Chorin, F., additional, Combe, B., additional, Compas, B., additional, Costa, D. J., additional, Costa, E., additional, Coste, O., additional, Coupet, A. -L., additional, Crepaldi, G., additional, Custovic, A., additional, Dahl, R., additional, Dahlen, S. E., additional, Demoly, P., additional, Devillier, P., additional, Didier, A., additional, Dinh-Xuan, A. T., additional, Djukanovic, R., additional, Dokic, D., additional, du Toit, G., additional, Dubakiene, R., additional, Dupeyron, A., additional, Emuzyte, R., additional, Fiocchi, A., additional, Wagner, A., additional, Fletcher, M., additional, Fonseca, J., additional, Fougère, B., additional, Gamkrelidze, A., additional, Garces, G., additional, Garcia-Aymeric, J., additional, Garcia-Zapirain, B., additional, Gemicioğlu, B., additional, Gouder, C., additional, Hellquist-Dahl, B., additional, Hermosilla-Gimeno, I., additional, Héve, D., additional, Holland, C., additional, Humbert, M., additional, Hyland, M., additional, Johnston, S. L., additional, Just, J., additional, Jutel, M., additional, Kaidashev, I. P., additional, Kaitov, M., additional, Kalayci, O., additional, Kalyoncu, A. F., additional, Keijser, W., additional, Kerstjens, H., additional, Knezović, J., additional, Kowalski, M., additional, Koppelman, G. H., additional, Kotska, T., additional, Kovac, M., additional, Kull, I., additional, Kuna, P., additional, Kvedariene, V., additional, Lepore, V., additional, Macnee, W., additional, Magnan, A., additional, Majer, I., additional, Manning, P., additional, Marcucci, M., additional, Marti, T., additional, Masoli, M., additional, Melen, E., additional, Miculinic, N., additional, Mihaltan, F., additional, Milenkovic, B., additional, Millot-Keurinck, J., additional, Mlinarić, H., additional, Momas, I., additional, Montefort, S., additional, Morais-Almeida, M., additional, Moreno-Casbas, T., additional, Mösges, R., additional, Mullol, J., additional, Nadif, R., additional, Nalin, M., additional, Navarro-Pardo, E., additional, Nekam, K., additional, Ninot, G., additional, Paccard, D., additional, Pais, S., additional, Palummeri, E., additional, Panzner, P., additional, Papadopoulos, N. K., additional, Papanikolaou, C., additional, Passalacqua, G., additional, Pastor, E., additional, Perrot, M., additional, Plavec, D., additional, Popov, T. A., additional, Postma, D. S., additional, Price, D., additional, Raffort, N., additional, Reuzeau, J. C., additional, Robine, J. M., additional, Rodenas, F., additional, Robusto, F., additional, Roche, N., additional, Romano, A., additional, Romano, V., additional, Rosado-Pinto, J., additional, Roubille, F., additional, Ruiz, F., additional, Ryan, D., additional, Salcedo, T., additional, Schmid-Grendelmeier, P., additional, Schulz, H., additional, Schunemann, H. J., additional, Serrano, E., additional, Sheikh, A., additional, Shields, M., additional, Siafakas, N., additional, Scichilone, N., additional, Skrindo, I., additional, Smit, H. A., additional, Sourdet, S., additional, Sousa-Costa, E., additional, Spranger, O., additional, Sooronbaev, T., additional, Sruk, V., additional, Sterk, P. J., additional, Todo-Bom, A., additional, Touchon, J., additional, Tramontano, D., additional, Triggiani, M., additional, Valero, A. L., additional, Valovirta, E., additional, van Ganse, E., additional, van Hage, M., additional, van den Berge, M., additional, Ventura, M. T., additional, Vergara, I., additional, Vezzani, G., additional, Vidal, D., additional, Viegi, G., additional, Wagemann, M., additional, Whalley, B., additional, Wilson, N., additional, Yiallouros, P. K., additional, Žagar, M., additional, Zaidi, A., additional, Zidarn, M., additional, Hoogerwerf, E. J., additional, Usero, J., additional, Zuffada, R., additional, Senn, A., additional, and de Oliveira-Alves, B., additional
Published: 2016
Full Text: View/download PDF

45. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): The new generation guideline implementation

Author: Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., Grisle, I., Lodrup Carlsen, K., Mullol, J., Muraro, A., Palkonen, S., Papadopoulos, N., Passalacqua, G., Ryan, D., Valovirta, E., Yorgancioglu, A., Aberer, W., Agache, I., Adachi, M., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bewick, M., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A. L., Boulet, L. P., Bonini, Matteo, Bonini, S., Bosse, I., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Carlsen, K. H., Carr, W., Cepeda Sarabia, A. M., Chavannes, N. H., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Ciprandi, G., Cirule, I., Correia De Sousa, J., Cox, L., Crooks, G., Costa, D. J., Custovic, A., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fink Wagner, A., Fletcher, M., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemiciotlu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grouse, L., Guzman, M. A., Haahtela, T., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Just, J., Kaidashev, I. P., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Khaltaev, N., Klimek, L., Koffi N'Goran, B., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Louis, R., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Mosges, R., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Scholl, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Price, D., Rabe, K. F., Raciborski, F., Radier Pontal, F., Repka-Ramirez, S., Robalo-Cordeiro, C., Rolland, C., Rosado-Pinto, J., Reitamo, S., Rodenas, F., Roman Rodriguez, M., Romano, Antonino, Rosario, N., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Serrano, E., Schmid-Grendelmeier, P., Sheikh, A., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, J., Bonini M. (ORCID:0000-0002-3042-0765), Romano A. (ORCID:0000-0003-3762-2084), Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., Grisle, I., Lodrup Carlsen, K., Mullol, J., Muraro, A., Palkonen, S., Papadopoulos, N., Passalacqua, G., Ryan, D., Valovirta, E., Yorgancioglu, A., Aberer, W., Agache, I., Adachi, M., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bewick, M., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A. L., Boulet, L. P., Bonini, Matteo, Bonini, S., Bosse, I., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Carlsen, K. H., Carr, W., Cepeda Sarabia, A. M., Chavannes, N. H., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Ciprandi, G., Cirule, I., Correia De Sousa, J., Cox, L., Crooks, G., Costa, D. J., Custovic, A., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fink Wagner, A., Fletcher, M., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemiciotlu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grouse, L., Guzman, M. A., Haahtela, T., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Just, J., Kaidashev, I. P., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Khaltaev, N., Klimek, L., Koffi N'Goran, B., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Louis, R., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Mosges, R., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Scholl, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Price, D., Rabe, K. F., Raciborski, F., Radier Pontal, F., Repka-Ramirez, S., Robalo-Cordeiro, C., Rolland, C., Rosado-Pinto, J., Reitamo, S., Rodenas, F., Roman Rodriguez, M., Romano, Antonino, Rosario, N., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Serrano, E., Schmid-Grendelmeier, P., Sheikh, A., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, J., Bonini M. (ORCID:0000-0002-3042-0765), and Romano A. (ORCID:0000-0003-3762-2084)
Abstract: Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards.
Published: 2015

46. Пептидэргическая регуляция почечных функций

Author: Vesnina, L. Ye., Kutsenko, L. O., Shlykova, O. A., Bobrova, N. O., Riabenko, V. V., Heiko, O. O., Kvak, O. V., Gordyns’ka, I. L., Sokolenko, V. M., Berkalo, L. V., and Kaidashev, I. P.
Subjects: kidneys, physiological regulation, regulatory peptides, renal peptide complex, нирки, фізіологічна регуляція, регуляторні пептиди, пептидний комплекс нирок, почки, физиологическая регуляция, регуляторные пептиды, пептидный комплекс почек
Abstract: Робота присвячена актуальній проблемі дослідження механізмів пептидергічної регуляції функції нирок за участю природного пептидного комплексу (ПКН), отриманого із кіркової речовини нирок. Показано, що ПКН володіє тканиноспецифічністю, здатністю впливати на функціональний стан нирок – на процеси фільтрації, реабсорбції та секреції за фізіологічних умов і при модуляції секреції та реабсорбції фізіологічно активними речовинами; впливати на стан біохімічних реакцій, гемокоагуляцію, біосинтез ДНК. Для ПКН визначено взаємодію з клітинами імунної системи – здатність модулювати активність лімфоцитів периферичної крові (переважно Т-клітин), викликати морфофункціональну перебудову в тимусі, відновлювати стан природної імунологічної толерантності організму лабораторних тварин до суміші тканинних антигенів, змінювати експресію поверхневих антигенних детермінант лімфоцитів та манозомісних мембранних структур, впливати на процеси апоптозу лімфоцитів та тимоцитів. Визначено фізіологічну активність ПКН стосовно показників периферичної крові та печінкових функцій. Синтезовано та досліджено вплив штучних пептидіваналогів ПКН – PEKDLRK, PEKDSRK, PEKDDRL. Результати роботи підтверджують існування в нирках локальної системи пептидної регуляції, яка реалізується шляхом утворення низькомолекулярних пептидних речовин та впливає на фізіологічні процеси не тільки в нирках, але й в інших органах та системах. Широкий спектр фізіологічної активності ПКН та синтетичних пептидів, створених на його основі, свідчить про перспективність подальшого їх дослідження з метою розробки ефективних лікарських засобів при нирковій патології., Работа посвящена актуальной проблеме исследования механизмов пептидэргической регуляции функции почек при участии природного пептидного комплекса, полученного из коркового вещества почек (ПКП). Показано, что ПКП обладает тканеспецифичностью, способностью влиять на функциональное состояние почек – на процессы фильтрации, реабсорбции и секреции при физиологических условиях и при модуляции секреции и реабсорбции физиологически активными веществами; влиять на состояние биохимических реакций, гемокоагуляцию, биосинтез ДНК. Для ПКП определено взаимодействие с клетками иммунной системы - способность модулировать активность лимфоцитов периферической крови (преимущественно Т-клеток), вызывать морфофункциональную перестройку в тимусе, восстанавливать состояние природной иммунологической толерантности организма лабораторных животных к смеси тканевых антигенов, изменять экспрессию поверхностных антигенных детерминант лимфоцитов и маннозосодержащих мембранных структур, влиять на процессы апоптоза лимфоцитов и тимоцитов. Определено физиологическую активность ПКП относительно показателей периферической крови и печеночных функций. Синтезировано и исследовано влияние синтетических пептидов-аналогов ПКП – PEKDLRK, PEKDSRK, PEKDDRL. Результаты работы подтверждают существование в почках локальной системы пептидной регуляции, которая реализуется путем образования низкомолекулярных пептидных веществ и влияет на физиологические процессы не только в почках, но и в других органах и системах. Широкий спектр физиологической активности ПКП и синтетических пептидов, созданных на его основе, свидетельствуют о перспективности дальнейшего их исследования с целью разработки эффективных лекарственных средств при почечной патологии., The paper discusses the topical research problem of the mechanisms of a peptidergic regulation of the renal function, involving the natural peptide complex derived from the renal cortical substance (RCS). It has been demonstrated that the RCS manifests tissue specifity, the ability to affect the renal functional status – the processes of filtration, reabsorption and secretion under physiological conditions and under the modulation of secretion and reabsorption by physiologically active substances; the ability to affect biochemical reactions, hemocoagulation, DNA biosynthesis. The following interaction with cells of the immune system has been determined for RCS: the ability to modulate the activity of peripheral blood lymphocytes (mainly T-cells); to induce morphofunctional restructuring in the thymus; to restore the natural state of immunological tolerance in the organism of laboratory animals to a mixture of tissue antigens; to alter the surface expression of antigenic determinants of lymphocytes and mannose-containing membrane structures; to influence on the apoptosis of lymphocytes and thymocytes. The physiological activity of the RCS pertaining to the indices of the peripheral blood and liver functions has been evaluated. The effect of synthetic peptide-analogues of the RCS (PEKDLRK, PEKDSRK, PEKDDRL) has been synthesized and investigated. The obtained results confirm the existence of a local peptide regulation system in the kidneys which is implemented through the formation of low molecular weight peptide substances and affects physiological processes not only in the kidneys, but also in other organs and systems. A wide range of the physiological activity of the RCS and synthetic peptides created on its basis are indicative of the prospects of their further research in order to develop effective medications for renal pathology.
Published: 2012

47. PIOGLITAZONE RESTORED MOUSE LUNG MRNA EXPRESSION OF CORE CLOCK, INFLAMMATION AND METABOLISM-RELATED GENES

Author: Shlykova, O., Izmailova, O., Kabaliei, A., Palchyk, V., Shynkevych, V., DuBuske, L., and Kaidashev, I.
Abstract: The circadian system regulates lung function as well as local and systemic inflammation. The alteration of this rhythmicity might be induced by the change in the eating rhythm. Peroxisome Proliferator-Activated Receptor Gamma (PPARG) is involved in circadian regulation, lung function and metabolism.
Published: 2023
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48. Clinical effectiveness of pioglitazone in the combination treatment of patients with asthma concurrent with coronary heart disease

Author: Byelan, O. V., primary, Borzykh, O. A., additional, Mamontova, T. V., additional, and Kaidashev, I. P., additional
Published: 2015
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49. Клінічна характеристика ефективності комбінації метформіну та раміприлу в комплексній терапії хворих з метаболічним синдромом

Author: Savchenko, L. G., primary, Kaidasheva, E. I., additional, Kutsenko, L. O., additional, Kutsenko, N. L., additional, Gordinska, I. L., additional, Mamontova, T. V., additional, Markina, T. M., additional, and Kaidashev, I. P., additional
Published: 2013
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50. Мета-анализ рандомизированных исследований антимикробных препаратов в лечении ишемической болезни сердца

Author: Skochko, O. V., primary and Kaidashev, I. P., additional
Published: 2012
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