Search

Your search keyword '"Kai, Dan"' showing total 376 results
Start Over Author "Kai, Dan"
376 results on '"Kai, Dan"'

14. Contributors

Author

Chai, Casandra Hui Teng, primary, Chan, Chui Yu, additional, Chen, Guo-Qiang, additional, Goh, Shermin S., additional, He, Chaobin, additional, Heng, Jerry Zhi Xiong, additional, Kai, Dan, additional, Koh, Junqiang Justin, additional, Li, Zibiao, additional, Lim, Jason Y.C., additional, Lin, Ming, additional, Loh, Xian Jun, additional, Mah, Justin Jian Qiang, additional, Muiruri, Joseph Kinyanjui, additional, Muthuraman, Sivasangari, additional, Qu, Chenyang, additional, Quek, Wei Kang, additional, Seah, Georgina E.K.K., additional, Sugiarto, Sigit, additional, Surat'man, Nayli Erdeanna, additional, Tan, Angeline Y.X., additional, Tan, Yee Lin, additional, Tan, Ying Chuan, additional, Tang, Karen Yuanting, additional, Tee, Si Yin, additional, Teo, Jerald Y.Q., additional, Toh, Yong Ming, additional, Truong, Tran Ngoc Bao, additional, Wang, Chen-Gang, additional, Wang, Chi-Hwa, additional, Wang, Sheng, additional, Ye, Enyi, additional, Yeo, Jayven Chee Chuan, additional, and Yeung, Celine W.S., additional

Published
2023
Full Text
View/download PDF

18. An economic evaluation of cabazitaxel versus a second androgen receptor-targeted agent (ARTA) for patients with metastatic castration-resistant prostate cancer previously treated with docetaxel and an ARTA: the United States payer perspective

Author

Alicia K. Morgans, Thomas Hutson, Alice Kai Dan Guan, David Garcia, Anna Zhou, Edward Drea, and Nicholas J. Vogelzang

Subjects
Cabazitaxel, Androgen receptor-targeted agent, Economic impact, Metastatic castration-resistant prostate cancer, Third-line treatment, Symptomatic skeletal events, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Cabazitaxel significantly improves clinical outcomes compared with a second androgen receptor-targeted agent (ARTA) in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel and an ARTA (abiraterone or enzalutamide), as demonstrated in the CARD trial (NCT02485691). We aimed to estimate healthcare costs avoided with the use of cabazitaxel as a third-line (3 L) treatment versus a second ARTA from a US payer perspective. Methods Model inputs were based on the CARD trial, published sources, and estimates of typical clinical care patterns by genitourinary oncologists (n = 3). Assessed time points were 6, 12, 18, and 24 months. Outcomes included progression-free survival (PFS), radiographic PFS (rPFS), and overall survival (OS); hospitalization and intensive care unit (ICU) days; and costs (reported in 2020 US dollar [USD] and converted into Euro) to manage symptomatic skeletal events (SSEs), adverse events (AEs), and end-of-life care. Results At 18 months, in a cohort of 100 patients, the use of cabazitaxel was estimated to result in 9 more patients achieving rPFS, 2 more patients achieving PFS, and 17 more survivors versus a second ARTA. The costs of SSEs, AEs, and end-of-life care were $498,909 (€424,073), $276,198 (€234,768), and $808,785 (€687,468), respectively, for cabazitaxel and $627,569 (€533,434), $251,124 (€213,455), and $1,028,294 (€874,050), respectively, for a second ARTA. Cabazitaxel was estimated to be associated with a 21% reduction in both SSE management and end-of-life care costs. Hospitalization cost was $1,442,870 (€1,226,440) for cabazitaxel and $1,728,394 (€1,469,135) for a second ARTA, representing an estimated 17% reduction in these costs. Cabazitaxel, as compared with a second ARTA, was associated with 58 fewer hospitalization days and 2 fewer ICU days and was estimated to avoid $323,095 (€274,630, 17%) in total costs, driven by SSEs management and end-of-life care. Conclusion The use of cabazitaxel as a 3 L treatment after docetaxel and an ARTA in patients with mCRPC is estimated to result in clinical benefits (longer rPFS, PFS, and OS) and lower healthcare resource utilization (fewer hospitalization and ICU days), compared with a second ARTA.

Published
2022
Full Text
View/download PDF

29. Nanochitin for sustainable and advanced manufacturing

Author

Chee, Pei Lin, primary, Sathasivam, Thenapakiam, additional, Tan, Ying Chuan, additional, Wu, Wenya, additional, Leow, Yihao, additional, Lim, Quentin Ray Tjieh, additional, Yew, Pek Yin Michelle, additional, Zhu, Qiang, additional, and Kai, Dan, additional

Published
2024
Full Text
View/download PDF

31. In Situ Characterization Techniques for Electrochemical Nitrogen Reduction Reaction

Author

Wu, Jing, Wang, Suxi, Ji, Rong, Kai, Dan, Kong, Junhua, Liu, Songlin, Thitsartarn, Warintorn, Tan, Beng Hoon, Chua, Ming Hui, Xu, Jianwei, Loh, Xian Jun, Yan, Qingyu, and Zhu, Qiang

Abstract

The electrochemical reduction of nitrogen to produce ammonia is pivotal in modern society due to its environmental friendliness and the substantial influence that ammonia has on food, chemicals, and energy. However, the current electrochemical nitrogen reduction reaction (NRR) mechanism is still imperfect, which seriously impedes the development of NRR. In situ characterization techniques offer insight into the alterations taking place at the electrode/electrolyte interface throughout the NRR process, thereby helping us to explore the NRR mechanism in-depth and ultimately promote the development of efficient catalytic systems for NRR. Herein, we introduce the popular theories and mechanisms of the electrochemical NRR and provide an extensive overview on the application of various in situ characterization approaches for on-site detection of reaction intermediates and catalyst transformations during electrocatalytic NRR processes, including different optical techniques, X-ray-based techniques, electron microscopy, and scanning probe microscopy. Finally, some major challenges and future directions of these in situ techniques are proposed.

Published
2024
Full Text
View/download PDF

33. Recent advancement in the development of silicon‐based phase change materials

Author

Yun Debbie Soo, Xiang, primary, Min Regine See, Jia, additional, Wu, Wenya, additional, Wang, Suxi, additional, Liu, Hongfei, additional, Wang, Pei, additional, Kai, Dan, additional, Kong, Junhua, additional, Ye, Enyi, additional, Ji, Rong, additional, Li, Zibiao, additional, Thitsartarn, Warintorn, additional, Hoon Tan, Beng, additional, Xu, Jianwei, additional, Jun Loh, Xian, additional, and Zhu, Qiang, additional

Published
2023
Full Text
View/download PDF

37. Functional Coatings for Built Environments based on Nanotechnology

Author

Ong, Pin Jin, primary, Wang, Suxi, additional, Suwardi, Ady, additional, Cao, Jing, additional, Wang, Fuke, additional, Yin, Xuesong, additional, Wang, Pei, additional, Wei, Fengxia, additional, Kai, Dan, additional, Ye, Enyi, additional, Xu, Jianwei, additional, Chua, Ming Hui, additional, Thitsartarn, Warintorn, additional, Zhu, Qiang, additional, and Loh, Xian Jun, additional

Published
2023
Full Text
View/download PDF

45. Green Nanocellulose/PEI‐Grafted Magnetic Nanoparticles for Effective Removal of Heavy Metal Ions.

Author

Sathasivam, Thenapakiam, Kang Brian, Lim, Andersen, Ingrid Marie, Ru Tan, Hui, Zhang, Zheng, Wu, Tingting, Hong Lau, Hooi, Zhu, Qiang, and Kai, Dan

Subjects
METAL ions, MAGNETIC nanoparticles, HEAVY metals, LANGMUIR isotherms, HEAVY metal toxicology
Abstract

In response to the pressing issue of water pollution caused by heavy metal ions, there is a growing demand for green adsorbents that can effectively remove these contaminants while being easy to separate and regenerate. A novel magnetic composite was synthesized by bonding amino‐functionalized Fe3O4−SiO2 magnetic particles (MNP‐NH2) to polyethyleneimine (PEI)‐grafted cellulose nanofibers (CNF). The modification of CNF with PEI through a peptidic coupling reaction resulted in the uniform dispersion and strong attachment of MNP‐NH2 particles (286.7 nm) onto the PEI‐CNF surface. This composite exhibited exceptional adsorption capabilities for heavy metals, achieving 16.73 mg/g for Pb, 16.12 mg/g for Cu, and 12.53 mg/g for Co. These remarkable adsorption capacities are attributed to the complex interactions between the metal ions and the amino, carboxyl, and hydroxyl groups on the surface of PEI‐CNF‐MNP. The introduction of PEI significantly enhanced the adsorption capacities, and the adsorption sequence (Pb(II)>Cu(II)>Co(II)) can be explained by differences in ionic radius and surface complexation strength. Langmuir isotherm and pseudo‐second‐order kinetic models described the adsorption process, while Na2EDTA was proved effective for desorption with high recovery rates. This magnetic composite holds promise for treating heavy metal‐contaminated wastewater due to its impressive performance. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

46. Synergistic Interface Engineering of RuO2/Co3O4 Heterostructures for Enhanced Overall Water Splitting in Acidic Media.

Author

Yang, Yiming, Wang, Luqi, Ma, Mingyue, Hu, Feng, Li, Linlin, Tan, Ying Chuan, Kai, Dan, Ren, Jianwei, and Peng, Shengjie

Subjects
HYDROGEN evolution reactions, OXYGEN evolution reactions, HETEROSTRUCTURES, CATALYTIC activity, HETEROJUNCTIONS, ENERGY conversion
Abstract

Designing nanocomposites with heterointerface as bifunctional electrocatalysts is a potential strategy to overcome the intrinsic activity limitation of electrocatalytic water splitting in acidic media, but it remains challenging. Herein, the highly efficient RuO2/Co3O4 electrocatalyst with a uniform nanoflower structure is prepared by hydrothermal growth combined with interface engineering. Benefiting from the unique nanostructure, the migration of electrons and intermediates is optimized by the sufficient exposure of abundant micropores and defects. Moreover, the formation of strong electronic interaction at the RuO2/Co3O4 heterointerfaces boosts the electrochemical active surface area and accelerates the reaction kinetics, which effectively improve the catalytic activity and stability of the catalyst. Based on enhanced intrinsic activity and electron transfer, the as‐synthesized RuO2/Co3O4 displays impressive hydrogen evolution reaction and oxygen evolution reaction activity, which respectively require low overpotentials of 240 and 100 mV to achieve a current density of 10 mA cm−2 in 0.5 m H2SO4. As a bifunctional electrode, RuO2/Co3O4 exhibits a low operating voltage of 1.58 V at 10 mA cm−2 for overall electrochemical water splitting. This study demonstrates the importance of heterostructure engineering in providing an avenue to achieve acid‐stable bifunctional electrocatalysts for energy conversion applications. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

49. Silicon-Containing Additives in Encapsulation of Phase Change Materials for Thermal Energy Storage

Author

Lee, Johnathan Joo Cheng, primary, Lim, Natalie Jia Xin, additional, Wang, Pei, additional, Liu, Hongfei, additional, Wang, Suxi, additional, Lee, Chi-Lik Ken, additional, Kai, Dan, additional, Wei, Fengxia, additional, Ji, Rong, additional, Tan, Beng Hoon, additional, Ge, Shaozhong, additional, Suwardi, Ady, additional, Xu, Jianwei, additional, Loh, Xian Jun, additional, and Zhu, Qiang, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results