1. Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
- Author
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Coussens, Nathan P, Sittampalam, G Sitta, Guha, Rajarshi, Brimacombe, Kyle, Grossman, Abigail, Chung, Thomas DY, Weidner, Jeffrey R, Riss, Terry, Trask, O Joseph, Auld, Douglas, Dahlin, Jayme L, Devanaryan, Viswanath, Foley, Timothy L, McGee, James, Kahl, Steven D, Kales, Stephen C, Arkin, Michelle, Baell, Jonathan, Bejcek, Bruce, Gal‐Edd, Neely, Glicksman, Marcie, Haas, Joseph V, Iversen, Philip W, Hoeppner, Marilu, Lathrop, Stacy, Sayers, Eric, Liu, Hanguan, Trawick, Bart, McVey, Julie, Lemmon, Vance P, Li, Zhuyin, McManus, Owen, Minor, Lisa, Napper, Andrew, Wildey, Mary Jo, Pacifici, Robert, Chin, William W, Xia, Menghang, Xu, Xin, Lal‐Nag, Madhu, Hall, Matthew D, Michael, Sam, Inglese, James, Simeonov, Anton, and Austin, Christopher P
- Subjects
Orphan Drug ,Rare Diseases ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Biological Assay ,Drug Discovery ,Geography ,High-Throughput Screening Assays ,Humans ,Translational Research ,Biomedical ,Cardiorespiratory Medicine and Haematology ,Oncology and Carcinogenesis ,Other Medical and Health Sciences ,General Clinical Medicine - Abstract
The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a "testing funnel" of assays to identify genuine hits using high-throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.
- Published
- 2018