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15 results on '"Kagerer, Sonja M."'

1. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Author

Abdi, Zeinab, Agosta, Federica, Ahmed, Samrah, Alcolea, Daniel, Allen, Isabel Elaine, Allinson, Kieren S.J., Apostolova, Liana G., Arighi, Andrea, Balasa, Mircea, Barkhof, Frederik, Best, John, Boon, Baayla D., Brandt, Katherine D., Brosch, Jared, Burrell, James, Butler, Christopher R., Calandri, Ismael, Caminiti, Silvia Paola, Canu, Elisa, Carrillo, Maria C., Caso, Francesca, Chapleau, Marianne, Chrem Mendez, Patricio, Chu, Min, Crutch, Sebastian, Cordato, Nicholas, Costa, Ana Sofia, Cui, Yue, Dickerson, Bradford, Dickson, Dennis W., Duara, Ranjan, Dubois, Bruno, Eldaief, Mark, Farlow, Martin, Fenoglio, Chiara, Filippi, Massimo, Fliessbach, Klaus, Formaglio, Maïté, Fortea, Juan, Fox, Nick, Foxe, David, Tilikete, Caroline Froment, Frosch, Matthew P., Fumagalli, Giorgio Giulio, Galasko, Douglas, Galimberti, Daniela, Garat, Oscar, Giardinieri, Giulia, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grinberg, Lea, Groot, Colin, Hake, Ann Marie, Hansson, Oskar, Headley, Alison, Hernandez, Micaela, Hochberg, Daisy, Hodges, John R., Hof, Patrick R., Holton, Janice, Hromas, Gabrielle, Gala, Ignacio Illán, Irwin, David J., Jaunmuktane, Zane, Jing, Donglai, Josephs, Keith, Kagerer, Sonja M., Kasuga, Kensaku, Kong, Yu, Kövari, Enikö, Lacombe-Thibault, Mégane, Lleó, Alberto, Laforce, Robert, La Joie, Renaud, Lashley, Tammaryn, Leger, Gabriel, Levin, Netta, Levy, Richard, Liu, Yang, Liu, Li, Lladó Plarrumaní, Albert, Lucente, Diane E., Machulda, Mary M., Magnani, Giuseppe, Magnin, Eloi, Malpetti, Maura, Matthews, Brandy, McGinnis, Scott, Mendez, Mario F., Mesulam, Marsel, Migliaccio, Raffaella, Miklitz, Carolin, Miller, Zachary A., Montembeault, Maxime, Murray, Melissa E., Mundada, Nidhi, Nemes, Sara, Nestor, Peter J., Ocal, Dilek, Ossenkoppele, Rik, Paterson, Ross, Pelak, Victoria, Perani, Daniela, Phillips, Jeffrey, Piguet, Olivier, Pijnenburg, Yolande, Putcha, Deepti, Quimby, Megan, Rabinovici, Gil D., Reetz, Kathrin, Rein, Netaniel, Revesz, Tamas, Rezaii, Neguine, Rodriguez-Porcel, Federico, Rogalski, Emily, Rowe, James B., Ryan, Natalie, Sanchez-Valle, Raquel, Sacchi, Luca, Santos-Santos, Miguel Ángel, Schott, Jonathan M., Seeley, William, Sherman, Janet, Spina, Salvatore, Stomrud, Erik, Sullivan, A. Campbell, Tanner, Jeremy, Tideman, Pontus, Tokutake, Takayoshi, Tondo, Giacomo, Touroutoglou, Alexandra, Tousi, Babak, Vandenberghe, Rik, van der Flier, Wiesje, Walker, Jamie M., Weintraub, Sandra, Whitwell, Jennifer L., Wolk, David A., Wong, Bonnie, Wu, Liyong, Xie, Kexin, Yong, Keir, Apostolova, Liana, Boon, Baayla D C, Grinberg, Lea T, Irwin, David J, Josephs, Keith A, Mendez, Mario F, Mendez, Patricio Chrem, Miller, Zachary A, Murray, Melissa E, Nemes, Sára, Schott, Jonathan M, Sullivan, A Campbell, Walker, Jamie, Whitwell, Jennifer L, Wolk, David A, and Rabinovici, Gil D

Published
2024
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3. Polygenic risk for Alzheimer’s disease is associated with neuroaxonal damage before onset of clinical symptoms

Author

Kagerer, Sonja M, Awasthi, Swapnil, Ripke, Stephan; https://orcid.org/0000-0003-3622-835X, Maceski, Aleksandra, Benkert, Pascal, Fall, Aïda B, Riederer, Peter, Fischer, Peter; https://orcid.org/0000-0002-2992-5037, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, Grünblatt, Edna; https://orcid.org/0000-0001-8505-7265, Kuhle, Jens, Unschuld, Paul G; https://orcid.org/0000-0002-6116-3386, Kagerer, Sonja M, Awasthi, Swapnil, Ripke, Stephan; https://orcid.org/0000-0003-3622-835X, Maceski, Aleksandra, Benkert, Pascal, Fall, Aïda B, Riederer, Peter, Fischer, Peter; https://orcid.org/0000-0002-2992-5037, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, Grünblatt, Edna; https://orcid.org/0000-0001-8505-7265, Kuhle, Jens, and Unschuld, Paul G; https://orcid.org/0000-0002-6116-3386

Published
2024

5. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Author

Chapleau, Marianne, primary, La Joie, Renaud, additional, Yong, Keir, additional, Agosta, Federica, additional, Allen, Isabel Elaine, additional, Apostolova, Liana, additional, Best, John, additional, Boon, Baayla D C, additional, Crutch, Sebastian, additional, Filippi, Massimo, additional, Fumagalli, Giorgio Giulio, additional, Galimberti, Daniela, additional, Graff-Radford, Jonathan, additional, Grinberg, Lea T, additional, Irwin, David J, additional, Josephs, Keith A, additional, Mendez, Mario F, additional, Mendez, Patricio Chrem, additional, Migliaccio, Raffaella, additional, Miller, Zachary A, additional, Montembeault, Maxime, additional, Murray, Melissa E, additional, Nemes, Sára, additional, Pelak, Victoria, additional, Perani, Daniela, additional, Phillips, Jeffrey, additional, Pijnenburg, Yolande, additional, Rogalski, Emily, additional, Schott, Jonathan M, additional, Seeley, William, additional, Sullivan, A Campbell, additional, Spina, Salvatore, additional, Tanner, Jeremy, additional, Walker, Jamie, additional, Whitwell, Jennifer L, additional, Wolk, David A, additional, Ossenkoppele, Rik, additional, Rabinovici, Gil D, additional, Abdi, Zeinab, additional, Ahmed, Samrah, additional, Alcolea, Daniel, additional, Allinson, Kieren S.J., additional, Arighi, Andrea, additional, Balasa, Mircea, additional, Barkhof, Frederik, additional, Brandt, Katherine D., additional, Brosch, Jared, additional, Burrell, James, additional, Butler, Christopher R., additional, Calandri, Ismael, additional, Caminiti, Silvia Paola, additional, Canu, Elisa, additional, Carrillo, Maria C., additional, Caso, Francesca, additional, Chu, Min, additional, Cordato, Nicholas, additional, Costa, Ana Sofia, additional, Cui, Yue, additional, Dickerson, Bradford, additional, Dickson, Dennis W., additional, Duara, Ranjan, additional, Dubois, Bruno, additional, Eldaief, Mark, additional, Farlow, Martin, additional, Feneglio, Chiara, additional, Fliessbach, Klaus, additional, Formaglio, Maïté, additional, Fortea, Juan, additional, Fox, Nick, additional, Foxe, David, additional, Tilikete, Caroline Froment, additional, Frosch, Matthew P., additional, Galasko, Douglas, additional, Garat, Oscar, additional, Giardinieri, Giulia, additional, Graff-Radford, Neill R., additional, Groot, Colin, additional, Hake, Ann Marie, additional, Hansson, Oskar, additional, Headley, Alison, additional, Hernandez, Micaela, additional, Hochberg, Daisy, additional, Hodges, John R., additional, Hof, Patrick R., additional, Holton, Janice, additional, Hromas, Gabrielle, additional, Illán Gala, Ignacio, additional, Jaunmuktane, Zane, additional, Jing, Donglai, additional, Kagerer, Sonja M., additional, Kasuga, Kensaku, additional, Kong, Yu, additional, Kövari, Enikö, additional, Lacombe-Thibault, Mégane, additional, Lleó Plarrumaní, Alberto, additional, Lucente, Diane E., additional, Machulda, Mary M., additional, Magnani, Giuseppe, additional, Magnin, Eloi, additional, Malpetti, Maura, additional, Matthews, Brandy, additional, McGinnis, Scott, additional, Mesulam, Marsel, additional, Miklitz, Carolin, additional, Mundada, Nidhi, additional, Nestor, Peter J., additional, Ocal, Dilek, additional, Paterson, Ross, additional, Piguet, Olivier, additional, Putcha, Deepti, additional, Quimby, Megan, additional, Reetz, Kathrin, additional, Rein, Netaniel, additional, Revesz, Tamas, additional, Rezaii, Neguine, additional, Rodriguez-Porcel, Federico, additional, Rowe, James B., additional, Ryan, Natalie, additional, Sanchez-Valle, Raquel, additional, Sacchi, Luca, additional, Santos-Santos, Miguel Ángel, additional, Sherman, Janet, additional, Stomrud, Erik, additional, Tideman, Pontus, additional, Tokutake, Takayoshi, additional, Tondo, Giacomo, additional, Touroutoglou, Alexandra, additional, Tousi, Babak, additional, Vandenberghe, Rik, additional, van der Flier, Wiesje, additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, Wu, Liyong, additional, and Xie, Kexin, additional

Published
2024
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6. Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms

Author

Kagerer, Sonja M., primary, Awasthi, Swapnil, additional, Ripke, Stephan, additional, Maceski, Aleksandra, additional, Benkert, Pascal, additional, Fall, Aïda B., additional, Riederer, Peter, additional, Fischer, Peter, additional, Walitza, Susanne, additional, Grünblatt, Edna, additional, Kuhle, Jens, additional, and Unschuld, Paul G., additional

Published
2024
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7. Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Author

Kagerer, Sonja M., primary, Schroeder, Clemens, additional, van Bergen, Jiri M. G., additional, Schreiner, Simon J., additional, Meyer, Rafael, additional, Steininger, Stefanie C., additional, Vionnet, Laetitia, additional, Gietl, Anton F., additional, Treyer, Valerie, additional, Buck, Alfred, additional, Pruessmann, Klaas P., additional, Hock, Christoph, additional, and Unschuld, Paul G., additional

Published
2022
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8. Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Author

Kagerer, Sonja M, Schroeder, Clemens, van Bergen, Jiri M G, Schreiner, Simon J, Meyer, Rafael, Steininger, Stefanie C, Vionnet, Laetitia, Gietl, Anton F, Treyer, Valerie, Buck, Alfred, Pruessmann, Klaas P, Hock, Christoph, Unschuld, Paul G, University of Zurich, and Unschuld, Paul G

Subjects
2805 Cognitive Neuroscience, Aging, ultra-high field MRI, 7 Tesla, hippocampus subfield segmentation, prodromal AD, episodic memory, iron, subiculum, Alzheimer's disease, Cognitive Neuroscience, 610 Medicine & health, 10181 Clinic for Nuclear Medicine, 11359 Institute for Regenerative Medicine (IREM), 1302 Aging
Abstract

Introduction: Hippocampal atrophy is an established Alzheimer’s Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations. Methods: Data from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks. Results: High cortical Aβ and low episodic memory interactively predicted subicular volume [F(3,57) = 5.90, p = 0.018]. The combination of high cortical Aβ and low episodic memory was associated with significantly lower subicular volumes, when compared to participants with high episodic memory (p = 0.004). Discussion: Our results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons., Frontiers in Aging Neuroscience, 14, ISSN:1663-4365

Published
2021

10. Beta‐amyloid‐associated episodic memory variation correlates with subicular volume in non‐demented old aged individuals

Author

Kagerer, Sonja M, primary, Schroeder, Clemens, additional, Van Bergen, Jiri M. G., additional, Schreiner, Simon J., additional, Meyer, Rafael, additional, Steininger, Stephanie C., additional, Laetitia, Vionnet, additional, Gietl, Anton F., additional, Treyer, Valerie, additional, Buck, Alfred, additional, Pruessmann, Klaas P., additional, Hock, Christoph, additional, and Unschuld, Paul G., additional

Published
2020
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11. Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4

Author

Quevenco, Frances C., primary, van Bergen, Jiri M., additional, Treyer, Valerie, additional, Studer, Sandro T., additional, Kagerer, Sonja M., additional, Meyer, Rafael, additional, Gietl, Anton F., additional, Kaufmann, Philipp A., additional, Nitsch, Roger M., additional, Hock, Christoph, additional, and Unschuld, Paul G., additional

Published
2020
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12. APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old‐aged adults

Author

Kagerer, Sonja M., primary, Bergen, Jiri M. G., additional, Li, Xu, additional, Quevenco, Frances C., additional, Gietl, Anton F., additional, Studer, Sandro, additional, Treyer, Valerie, additional, Meyer, Rafael, additional, Kaufmann, Philipp A., additional, Nitsch, Roger M., additional, Zijl, Peter C. M., additional, Hock, Christoph, additional, and Unschuld, Paul G., additional

Published
2020
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13. APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults

Author

Kagerer, Sonja M., van Bergen, Jiri M. G., Li, Xu, Quevenco, Frances C., Gietl, Anton F., Studer, Sandro, Treyer, Valerie, Meyer, Rafael, Kaufmann, Philipp A., Nitsch, Roger M., van Zijl, Peter C. M., Hock, Christoph, and Unschuld, Paul G.

Subjects
APOE4, fMRI, QSM, 3. Good health, gradient echo, iron, PET, mental disorders, preclinical Alzheimer’s disease, DMN, ICA, human activities, flutemetamol, MRI
Abstract

Introduction: Apolipoprotein E ε4 (APOE4)–related genetic risk for sporadic Alzheimer's disease is associated with an early impairment of cognitive brain networks. The current study determines relationships between APOE4 carrier status, cortical iron, and cortical network-functionality. Methods: Sixty-nine cognitively healthy old-aged individuals (mean age [SD] 66.1 [± 7.2] years; Mini-Mental State Exam [MMSE] 29.3 ± 1.1) were genotyped for APOE4 carrier-status and received 3 Tesla magnetic resonance imaging (MRI) for blood oxygen level–dependent functional magnetic resonance imaging (MRI) at rest, three-dimensional (3D)–gradient echo (six echoes) for cortical gray-matter, non-heme iron by quantitative susceptibility mapping, and 18F-flutemetamol positron emission tomography for amyloid-β. Results: A spatial pattern consistent with the default mode network (DMN) could be identified by independent component analysis. DMN activity was enhanced in APOE4 carriers and related to cortical iron burden. APOE4 and cortical iron synergistically interacted with DMN activity. Secondary analysis revealed a positive, APOE4 associated, relationship between cortical iron and DMN connectivity. Discussion: Our findings suggest that APOE4 moderates effects of iron on brain functionality prior to manifestation of cognitive impairment. © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association., Alzheimer's and Dementia. Diagnosis, Assessment and Disease Monitoring, 12 (1), ISSN:2352-8729

14. Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms.

Author

Kagerer SM, Awasthi S, Ripke S, Maceski A, Benkert P, Fall AB, Riederer P, Fischer P, Walitza S, Grünblatt E, Kuhle J, and Unschuld PG

Abstract

Introduction: Establishing valid diagnostic strategies is a precondition for successful therapeutic intervention in Alzheimer's disease (AD)., Methods: One hundred forty-four healthy 75-year-old participants from the Vienna-Transdanube-Aging longitudinal cohort study were tested for neuroaxonal damage by single molecular array (Simoa) plasma neurofilament light chain (NfL) levels at baseline, 30, 60, and 90 months, and onset of AD dementia. Individual risk for sporadic AD was estimated by continuous shrinkage polygenic risk score (PRS-CS, genome-wide association study)., Results: Nineteen participants developed AD after a median of 60 months (interquartile range 30). In participants with AD, baseline NfL plasma levels correlated with PRS-CS ( r  = 0.75, p  < 0.001; difference to controls: Fisher's r -to- z : z  = 3.89, p  < 0.001). PRS-CS combined with baseline plasma NfL predicted onset of AD ( p  < 0.01)., Discussion: Our data suggest that polygenic risk for AD and plasma NfL closely interact years before onset of clinical symptoms. Peripheral NfL may serve as a diagnostic measure supporting early therapeutic intervention and secondary prevention in AD., Competing Interests: The authors declare no conflicts of interest. Author disclosures are available in the supporting information., (© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2024
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15. APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults.

Author

Kagerer SM, van Bergen JMG, Li X, Quevenco FC, Gietl AF, Studer S, Treyer V, Meyer R, Kaufmann PA, Nitsch RM, van Zijl PCM, Hock C, and Unschuld PG

Abstract

Introduction: Apolipoprotein E ε4 (APOE4)-related genetic risk for sporadic Alzheimer's disease is associated with an early impairment of cognitive brain networks. The current study determines relationships between APOE4 carrier status, cortical iron, and cortical network-functionality., Methods: Sixty-nine cognitively healthy old-aged individuals (mean age [SD] 66.1 [± 7.2] years; Mini-Mental State Exam [MMSE] 29.3 ± 1.1) were genotyped for APOE4 carrier-status and received 3 Tesla magnetic resonance imaging (MRI) for blood oxygen level-dependent functional magnetic resonance imaging (MRI) at rest, three-dimensional (3D)-gradient echo (six echoes) for cortical gray-matter, non-heme iron by quantitative susceptibility mapping, and 18F-flutemetamol positron emission tomography for amyloid-β., Results: A spatial pattern consistent with the default mode network (DMN) could be identified by independent component analysis. DMN activity was enhanced in APOE4 carriers and related to cortical iron burden. APOE4 and cortical iron synergistically interacted with DMN activity. Secondary analysis revealed a positive, APOE4 associated, relationship between cortical iron and DMN connectivity., Discussion: Our findings suggest that APOE4 moderates effects of iron on brain functionality prior to manifestation of cognitive impairment., (© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association.)

Published
2020
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