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6. Use of genome‐wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high‐grade B‐cell lymphoma

Author

Teoh, Yong Bin, primary, Ishizaki, Teita, additional, Kagawa, Yumiko, additional, Yokoyama, Shoko, additional, Jelinek, Jaroslav, additional, Matsumoto, Yuki, additional, Tomiyasu, Hirotaka, additional, Tsujimoto, Hajime, additional, Takiguchi, Mitsuyoshi, additional, and Yamazaki, Jumpei, additional

Published
2023
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8. PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma

Author

Maekawa, Naoya, Konnai, Satoru, Nishimura, Maki, Kagawa, Yumiko, Takagi, Satoshi, Hosoya, Kenji, Ohta, Hiroshi, Kim, Sangho, Okagawa, Tomohiro, Izumi, Yusuke, Deguchi, Tatsuya, Kato, Yukinari, Yamamoto, Satoshi, Yamamoto, Keiichi, Toda, Mikihiro, Nakajima, Chie, Suzuki, Yasuhiko, Murata, Shiro, and Ohashi, Kazuhiko

Published
2021
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10. Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours

Author

Maekawa, Naoya, primary, Konnai, Satoru, additional, Hosoya, Kenji, additional, Kim, Sangho, additional, Kinoshita, Ryohei, additional, Deguchi, Tatsuya, additional, Owaki, Ryo, additional, Tachibana, Yurika, additional, Yokokawa, Madoka, additional, Takeuchi, Hiroto, additional, Kagawa, Yumiko, additional, Takagi, Satoshi, additional, Ohta, Hiroshi, additional, Kato, Yukinari, additional, Yamamoto, Satoshi, additional, Yamamoto, Keiichi, additional, Suzuki, Yasuhiko, additional, Okagawa, Tomohiro, additional, Murata, Shiro, additional, and Ohashi, Kazuhiko, additional

Published
2023
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11. Diverse genome‐wide DNA methylation alterations in canine hepatocellular tumours

Author

Asari, Yu, primary, Yamazaki, Jumpei, additional, Thandar, Oo, additional, Suzuki, Tamami, additional, Aoshima, Keisuke, additional, Takeuchi, Kyosuke, additional, Kinoshita, Ryohei, additional, Kim, Sangho, additional, Hosoya, Kenji, additional, Ishizaki, Teita, additional, Kagawa, Yumiko, additional, Jelinek, Jaroslav, additional, Yokoyama, Shoko, additional, Sasaki, Noboru, additional, Ohta, Hiroshi, additional, Nakamura, Kensuke, additional, and Takiguchi, Mitsuyoshi, additional

Published
2023
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12. An inflammatory bowel disease-associated SNP increases local thyroglobulin expression to develop inflammation in miniature dachshunds

Author

Teoh, Yong Bin, primary, Jiang, Jing-Jing, additional, Yamasaki, Takeshi, additional, Nagata, Noriyuki, additional, Sugawara, Toshiki, additional, Hasebe, Rie, additional, Ohta, Hiroshi, additional, Sasaki, Noboru, additional, Yokoyama, Nozomu, additional, Nakamura, Kensuke, additional, Kagawa, Yumiko, additional, Takiguchi, Mitsuyoshi, additional, and Murakami, Masaaki, additional

Published
2023
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13. Successful treatment of sclerosing encapsulating peritonitis in a cat using bioresorbable hyaluronate-carboxymethylcellulose membrane after surgical adhesiolysis and long-term prednisolone

Author

Yokoyama, Nozomu, primary, Kinoshita, Ryohei, additional, Ohta, Hiroshi, additional, Okada, Kazuki, additional, Shimbo, Genya, additional, Sasaoka, Kazuyoshi, additional, Nagata, Noriyuki, additional, Sasaki, Noboru, additional, Morishita, Keitaro, additional, Nakamura, Kensuke, additional, Kagawa, Yumiko, additional, and Takiguchi, Mitsuyoshi, additional

Published
2023
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15. Transcriptome and proteome analysis of dogs with precursor targeted immune-mediated anemia treated with splenectomy

Author

Sugawara-Suda, Mei, primary, Morishita, Keitaro, additional, Ichii, Osamu, additional, Namba, Takashi, additional, Aoshima, Keisuke, additional, Kagawa, Yumiko, additional, Kim, Sangho, additional, Hosoya, Kenji, additional, Yokoyama, Nozomu, additional, Sasaki, Noboru, additional, Nakamura, Kensuke, additional, Yamazaki, Jumpei, additional, and Takiguchi, Mitsuyoshi, additional

Published
2023
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16. Immunohistochemical analyses of neural stem cell lineage markers in normal feline brains and glial tumors.

Author

Yoshida, Kio, Chambers, James K., Nibe, Kazumi, Kagawa, Yumiko, and Uchida, Kazuyuki

Subjects
NEURAL stem cells, GLIOMAS, CAT diseases, GLIAL fibrillary acidic protein, IMMUNOHISTOCHEMISTRY, ASTROCYTOMAS, TRANSCRIPTION factors
Abstract

Neural stem cell (NSC) lineage cells have not been fully identified in feline brains, and the NSC-like nature of feline glial tumors has not been determined. In this study, 6 normal cat brains (3 newborn and 3 older cats) and 13 feline glial tumors were analyzed using immunohistochemical NSC lineage markers. The feline glial tumors were subjected to immunohistochemical scoring followed by hierarchical cluster analysis. In newborn brains, glial acidic fibrillary protein (GFAP)/nestin/sex-determining region Y-box transcription factor 2 (SOX2)-immunopositive NSCs, SOX2-immunopositive intermediate progenitor cells, oligodendrocyte transcription factor 2 (OLIG2)/platelet-derived growth factor receptor-α (PDGFR-α)-immunopositive oligodendrocyte precursor cells (OPCs), OLIG2/GFAP-immunopositive immature astrocytes, and neuronal nuclear (NeuN)/β-3 tubulin-immunopositive mature neuronal cells were observed. The apical membrane of NSCs was also immunopositive for Na+/H+ exchanger regulatory factor 1 (NHERF1). In mature brains, the NSC lineage cells were similar to those of the newborn brains. A total of 13 glial tumors consisted of 2 oligodendrogliomas, 4 astrocytomas, 3 subependymomas, and 4 ependymomas. Astrocytomas, subependymomas, and ependymomas were immunopositive for GFAP, nestin, and SOX2. Subependymomas and ependymomas showed dot-like or apical membrane immunolabeling for NHERF1, respectively. Astrocytomas were immunopositive for OLIG2. Oligodendrogliomas and subependymomas were immunopositive for OLIG2 and PDGFR-α. Feline glial tumors also showed variable immunolabeling for β-3 tubulin, NeuN, and synaptophysin. Based on these results, feline astrocytomas, subependymomas, and ependymomas appear to have an NSC-like immunophenotype. In addition, astrocytomas, subependymomas, and ependymomas have the characteristics of glial, oligodendrocyte precursor, and ependymal cells, respectively. Feline oligodendrogliomas likely have an OPC-like immunophenotype. In addition, feline glial tumors may have multipotential stemness for differentiation into neuronal cells. These preliminary results should be validated by gene expression analyses in future studies with larger case numbers. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Use of genome‐wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high‐grade B‐cell lymphoma.

Author

Teoh, Yong Bin, Ishizaki, Teita, Kagawa, Yumiko, Yokoyama, Shoko, Jelinek, Jaroslav, Matsumoto, Yuki, Tomiyasu, Hirotaka, Tsujimoto, Hajime, Takiguchi, Mitsuyoshi, and Yamazaki, Jumpei

Subjects
DNA methylation, DNA analysis, SURVIVAL analysis (Biometry), EPIGENOMICS, DOGS, SURVIVAL rate
Abstract

Background: DNA methylation analysis might identify prognostic CpG sites in CHOP‐treated dogs with multicentric high‐grade B‐cell lymphoma (MHGL) with heterogenous prognosis. Objective: To identify prognostic CpG sites of MHGL through genome‐wide DNA methylation analysis with pyrosequencing validation. Animals: Test group: 24 dogs. Validation group: 100 dogs. All client‐owned dogs were diagnosed with MHGL and treated with CHOP chemotherapy. Methods: Cohort study. DNA was extracted from lymph node samples obtained via FNA. Genome‐wide DNA methylation analysis using Digital Restriction Enzyme Analysis of Methylation (DREAM) was performed on the test group to identify differentially methylated CpG sites (DMCs). Bisulfite pyrosequencing was used to measure methylation status of candidate DMCs in the validation group. Median survival times (MST) were analyzed using Kaplan‐Meier (log‐rank) product limit method. Results: DREAM analyzed 101 576 CpG sites. Hierarchical clustering of 16 262 CpG sites in test group identified group with better prognosis (MST = 55‐477 days vs 10‐301 days, P =.007). Volcano plot identified 1371 differentially methylated CpG sites (DMCs). DMC near the genes of FAM213A (DMC‐F) and PHLPP1 (DMC‐P) were selected as candidates. Bisulfite‐pyrosequencing performed on validation group showed group with methylation level of DMC‐F < 40% had favorable prognosis (MST = 11‐1072 days vs 8‐1792 days, P =.01), whereas group with the methylation level combination of DMC‐F < 40% plus DMC‐P < 10% had excellent prognosis (MST = 18‐1072 days vs 8‐1792 days, P =.009). Conclusion and Clinical Importance: Methylation status of prognostic CpG sites delineate canine MGHL cases with longer MST, providing owners with information on expectations of potential improved treatment outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Molecular characterization of feline immune checkpoint molecules and establishment of PD-L1 immunohistochemistry for feline tumors

Author

1000070829035, Maekawa, Naoya, 1000040396304, Konnai, Satoru, Asano, Yumie, Otsuka, Takumi, Aoki, Eri, Takeuchi, Hiroto, Kato, Yukinari, Kaneko, Mika K., Yamada, Shinji, Kagawa, Yumiko, Nishimura, Maki, Takagi, Satoshi, Deguchi, Tatsuya, Ohta, Hiroshi, Nakagawa, Takayuki, 1000090206540, Suzuki, Yasuhiko, 1000080829036, Okagawa, Tomohiro, 1000010579163, Murata, Shiro, 1000090250498, Ohashi, Kazuhiko, 1000070829035, Maekawa, Naoya, 1000040396304, Konnai, Satoru, Asano, Yumie, Otsuka, Takumi, Aoki, Eri, Takeuchi, Hiroto, Kato, Yukinari, Kaneko, Mika K., Yamada, Shinji, Kagawa, Yumiko, Nishimura, Maki, Takagi, Satoshi, Deguchi, Tatsuya, Ohta, Hiroshi, Nakagawa, Takayuki, 1000090206540, Suzuki, Yasuhiko, 1000080829036, Okagawa, Tomohiro, 1000010579163, Murata, Shiro, 1000090250498, and Ohashi, Kazuhiko

Abstract

Spontaneous tumors are a major cause of death in cats. Treatment of human tumors has progressed dramatically in the past decade, partly due to the success of immunotherapies using immune checkpoint inhibitors, such as anti-programmed death 1 (PD-1) and anti-PD-ligand 1 (PD-L1) antibodies. However, little is known about the PD-1 pathway and its association with tumor disease in cats. This study investigated the applicability of anti-PD-1/PD-L1 therapy in feline tumors. We first determined the complete coding sequence of feline PD-L1 and PD-L2, and found that the deduced amino acid sequences of feline PD-L1/PD-L2 share high sequence identities (66-83%) with orthologs in other mammalian species. We prepared recombinant feline PD-1, PD-L1, and PD-L2 proteins and confirmed receptor-ligand binding between PD-1 and PD-L1/PD-L2 using flow cytometry. Next, we established an anti-feline PD-L1 monoclonal antibody (clone CL1Mab-7) to analyze the expression of PD-L1. Flow cytometry using CL1Mab-7 revealed the cell surface expression of PD-L1 in a feline macrophage (Fcwf-4) and five mammary adenocarcinoma cell lines (FKNp, FMCm, FYMp, FONp, and FONm), and showed that PD-L1 expression was upregulated by interferon-gamma stimulation. Finally, immunohistochemistry using CL1Mab-7 also showed PD-L1 expression in feline squamous cell carcinoma (5/5, 100%), mammary adenocarcinoma (4/5, 80%), fibrosarcoma (5/5, 100%), and renal cell carcinoma (2/2, 100%) tissues. Our results strongly encourage further investigations of the PD-1/PD-L1 pathway as a potential therapeutic target for feline tumors.

Published
2023

20. PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma

Author

Maekawa, Naoya, Konnai, Satoru, Nishimura, Maki, Kagawa, Yumiko, Takagi, Satoshi, Hosoya, Kenji, Ohta, Hiroshi, Kim, Sangho, Okagawa, Tomohiro, Izumi, Yusuke, Deguchi, Tatsuya, Kato, Yukinari, Yamamoto, Satoshi, Yamamoto, Keiichi, Toda, Mikihiro, Nakajima, Chie, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko, Maekawa, Naoya, Konnai, Satoru, Nishimura, Maki, Kagawa, Yumiko, Takagi, Satoshi, Hosoya, Kenji, Ohta, Hiroshi, Kim, Sangho, Okagawa, Tomohiro, Izumi, Yusuke, Deguchi, Tatsuya, Kato, Yukinari, Yamamoto, Satoshi, Yamamoto, Keiichi, Toda, Mikihiro, Nakajima, Chie, Suzuki, Yasuhiko, Murata, Shiro, and Ohashi, Kazuhiko

Abstract

type:Article, Immunotherapy targeting programmed cell death 1 (PD-1) and PD-ligand 1 (PD-L1) represents promising treatments for human cancers. Our previous studies demonstrated PD-L1 overexpression in some canine cancers, and suggested the therapeutic potential of a canine chimeric anti-PD-L1 monoclonal antibody (c4G12). However, such evidence is scarce, limiting the clinical application in dogs. In the present report, canine PD-L1 expression was assessed in various cancer types, using a new anti-PD-L1 mAb, 6C11-3A11, and the safety and efficacy of c4G12 were explored in 29 dogs with pulmonary metastatic oral malignant melanoma (OMM). PD-L1 expression was detected in most canine malignant cancers including OMM, and survival was significantly longer in the c4G12 treatment group (median 143 days) when compared to a historical control group (n = 15, median 54 days). In dogs with measurable disease (n = 13), one dog (7.7%) experienced a complete response. Treatment-related adverse events of any grade were observed in 15 dogs (51.7%). Here we show that PD-L1 is a promising target for cancer immunotherapy in dogs, and dogs could be a useful large animal model for human cancer research.

Published
2023

21. Molecular characterization of feline immune checkpoint molecules and establishment of PD-L1 immunohistochemistry for feline tumors

Author

Maekawa, Naoya, Konnai, Satoru, Asano, Yumie, Otsuka, Takumi, Aoki, Eri, Takeuchi, Hiroto, Kato, Yukinari, Kaneko, Mika K., Yamada, Shinji, Kagawa, Yumiko, Nishimura, Maki, Takagi, Satoshi, Deguchi, Tatsuya, Ohta, Hiroshi, Nakagawa, Takayuki, Suzuki, Yasuhiko, Okagawa, Tomohiro, Murata, Shiro, Ohashi, Kazuhiko, Maekawa, Naoya, Konnai, Satoru, Asano, Yumie, Otsuka, Takumi, Aoki, Eri, Takeuchi, Hiroto, Kato, Yukinari, Kaneko, Mika K., Yamada, Shinji, Kagawa, Yumiko, Nishimura, Maki, Takagi, Satoshi, Deguchi, Tatsuya, Ohta, Hiroshi, Nakagawa, Takayuki, Suzuki, Yasuhiko, Okagawa, Tomohiro, Murata, Shiro, and Ohashi, Kazuhiko

Abstract

Spontaneous tumors are a major cause of death in cats. Treatment of human tumors has progressed dramatically in the past decade, partly due to the success of immunotherapies using immune checkpoint inhibitors, such as anti-programmed death 1 (PD-1) and anti-PD-ligand 1 (PD-L1) antibodies. However, little is known about the PD-1 pathway and its association with tumor disease in cats. This study investigated the applicability of anti-PD-1/PD-L1 therapy in feline tumors. We first determined the complete coding sequence of feline PD-L1 and PD-L2, and found that the deduced amino acid sequences of feline PD-L1/PD-L2 share high sequence identities (66-83%) with orthologs in other mammalian species. We prepared recombinant feline PD-1, PD-L1, and PD-L2 proteins and confirmed receptor-ligand binding between PD-1 and PD-L1/PD-L2 using flow cytometry. Next, we established an anti-feline PD-L1 monoclonal antibody (clone CL1Mab-7) to analyze the expression of PD-L1. Flow cytometry using CL1Mab-7 revealed the cell surface expression of PD-L1 in a feline macrophage (Fcwf-4) and five mammary adenocarcinoma cell lines (FKNp, FMCm, FYMp, FONp, and FONm), and showed that PD-L1 expression was upregulated by interferon-gamma stimulation. Finally, immunohistochemistry using CL1Mab-7 also showed PD-L1 expression in feline squamous cell carcinoma (5/5, 100%), mammary adenocarcinoma (4/5, 80%), fibrosarcoma (5/5, 100%), and renal cell carcinoma (2/2, 100%) tissues. Our results strongly encourage further investigations of the PD-1/PD-L1 pathway as a potential therapeutic target for feline tumors.

Published
2023

22. Molecular characterization of feline immune checkpoint molecules and establishment of PD-L1 immunohistochemistry for feline tumors

Author

Maekawa, Naoya, primary, Konnai, Satoru, additional, Asano, Yumie, additional, Otsuka, Takumi, additional, Aoki, Eri, additional, Takeuchi, Hiroto, additional, Kato, Yukinari, additional, Kaneko, Mika K., additional, Yamada, Shinji, additional, Kagawa, Yumiko, additional, Nishimura, Maki, additional, Takagi, Satoshi, additional, Deguchi, Tatsuya, additional, Ohta, Hiroshi, additional, Nakagawa, Takayuki, additional, Suzuki, Yasuhiko, additional, Okagawa, Tomohiro, additional, Murata, Shiro, additional, and Ohashi, Kazuhiko, additional

Published
2023
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23. Investigation of the therapeutic effects, predictors, and complications of long-term immunosuppressive therapy in dogs with precursor-targeted immune-mediated anemia

Author

SUGAWARA-SUDA, Mei, primary, MORISHITA, Keitaro, additional, IWANAGA, Yuto, additional, YAMAZAKI, Jumpei, additional, KAGAWA, Yumiko, additional, YOKOYAMA, Nozomu, additional, SASAKI, Noboru, additional, OHTA, Hiroshi, additional, NAKAMURA, Kensuke, additional, and TAKIGUCHI, Mitsuyoshi, additional

Published
2023
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28. sj-pdf-1-vet-10.1177_03009858231182337 – Supplemental material for Immunohistochemical analyses of neural stem cell lineage markers in normal feline brains and glial tumors

Author

Yoshida, Kio, Chambers, James K., Nibe, Kazumi, Kagawa, Yumiko, and Uchida, Kazuyuki

Subjects
Veterinary Medicine, Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-vet-10.1177_03009858231182337 for Immunohistochemical analyses of neural stem cell lineage markers in normal feline brains and glial tumors by Kio Yoshida, James K. Chambers, Kazumi Nibe, Yumiko Kagawa and Kazuyuki Uchida in Veterinary Pathology

Published
2023
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37. Radiographic characteristics of canine subungual keratoacanthoma

Author

Toshima, Atsushi, primary, Fulkerson, Caroline V., additional, Oetelaar, Garret S., additional, Kagawa, Yumiko, additional, Aoki, Hajime, additional, Higuchi, Masami, additional, Sawa, Kotomi, additional, Kawamura, Yozo, additional, Seino, Kaji, additional, Sugiyama, Atsushi, additional, Otaki, Shogo, additional, and Murakami, Masahiro, additional

Published
2022
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39. sj-pdf-1-vdi-10.1177_10406387221081227 ��� Supplemental material for Severe osteogenesis imperfecta caused by CREB3L1 mutation in a cat

Author

Takanosu, Masamine and Kagawa, Yumiko

Subjects
nervous system, 70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-vdi-10.1177_10406387221081227 for Severe osteogenesis imperfecta caused by CREB3L1 mutation in a cat by Masamine Takanosu and Yumiko Kagawa in Journal of Veterinary Diagnostic Investigation

Published
2022
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40. sj-pdf-1-vdi-10.1177_10406387221116285 – Supplemental material for A clonality analysis based on T-cell receptor beta and delta loci for high-grade gastrointestinal lymphoma in dogs

Author

Takanosu, Masamine and Kagawa, Yumiko

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-vdi-10.1177_10406387221116285 for A clonality analysis based on T-cell receptor beta and delta loci for high-grade gastrointestinal lymphoma in dogs by Masamine Takanosu and Yumiko Kagawa in Journal of Veterinary Diagnostic Investigation

Published
2022
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41. sj-pdf-1-vet-10.1177_03009858221087630 – Supplemental material for Gastrointestinal stromal tumors with Kit gene mutation in 4 guinea pigs (Cavia porcellus)

Author

Ueda, Kengo, Takanosu, Masamine, Kagawa, Yumiko, Ueda, Akiko, Ano, Naoko, Nomura, Kohji, and Ozaki, Kiyokazu

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, fungi, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-vet-10.1177_03009858221087630 for Gastrointestinal stromal tumors with Kit gene mutation in 4 guinea pigs (Cavia porcellus) by Kengo Ueda, Masamine Takanosu, Yumiko Kagawa, Akiko Ueda, Naoko Ano, Kohji Nomura and Kiyokazu Ozaki in Veterinary Pathology

Published
2022
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46. Veterinary Pathology

Author

Meuten, Donald J., Moore, Frances M., Donovan, Taryn A., Bertram, Christof A., Klopfleisch, Robert, Foster, Robert A., Smedley, Rebecca C., Dark, Michael J., Milovancev, Milan, Stromberg, Paul, Williams, Bruce H., Aubreville, Marc, Avallone, Giancarlo, Bolfa, Pompei, Cullen, John, Dennis, Michelle M., Goldschmidt, Michael, Luong, Richard, Miller, Andrew D., Miller, Margaret A., Munday, John S., Roccabianca, Paola, Salas, Elisa N., Schulman, F. Yvonne, Laufer-Amorim, Renee, Asakawa, Midori G., Craig, Linden, Dervisis, Nikolaos G., Esplin, D. Glen, George, Jeanne W., Hauck, Marlene, Kagawa, Yumiko, Kiupel, Matti, Linder, Keith, Meichner, Kristina, Marconato, Laura, Oblak, Michelle L., Santos, Renato L., Simpson, R. Mark, Tvedten, Harold, and Whitley, Derick

Subjects
standardization, validation, MITOTIC FIGURES, protocols, Reproducibility of Results, VASCULAR INVASION, PERIVASCULAR WALL TUMORS, SOFT-TISSUE SARCOMAS, SURGICAL EXCISION, Neoplasms, oncology, PROGNOSTIC-SIGNIFICANCE, NERVE SHEATH TUMORS, BREAST-CANCER, Animals, guidelines, IMMUNOHISTOCHEMICAL MARKERS, Pathology, Veterinary, MAST-CELL TUMORS, Cancer
Abstract

Standardization of tumor assessment lays the foundation for validation of grading systems, permits reproducibility of oncologic studies among investigators, and increases confidence in the significance of study results. Currently, there is minimal methodological standardization for assessing tumors in veterinary medicine, with few attempts to validate published protocols and grading schemes. The current article attempts to address these shortcomings by providing standard guidelines for tumor assessment parameters and protocols for evaluating specific tumor types. More detailed information is available in the Supplemental Files, the intention of which is 2-fold: publication as part of this commentary, but more importantly, these will be available as “living documents” on a website (www.vetcancerprotocols.org), which will be updated as new information is presented in the peer-reviewed literature. Our hope is that veterinary pathologists will agree that this initiative is needed, and will contribute to and utilize this information for routine diagnostic work and oncologic studies. Journal editors and reviewers can utilize checklists to ensure publications include sufficient detail and standardized methods of tumor assessment. To maintain the relevance of the guidelines and protocols, it is critical that the information is periodically updated and revised as new studies are published and validated with the intent of providing a repository of this information. Our hope is that this initiative (a continuation of efforts published in this journal in 2011) will facilitate collaboration and reproducibility between pathologists and institutions, increase case numbers, and strengthen clinical research findings, thus ensuring continued progress in veterinary oncologic pathology and improving patient care. Accepted version

Published
2021

48. International Guidelines for Veterinary Tumor Pathology: A Call to Action

Author

Meuten, Donald J., primary, Moore, Frances M., additional, Donovan, Taryn A., additional, Bertram, Christof A., additional, Klopfleisch, Robert, additional, Foster, Robert A., additional, Smedley, Rebecca C., additional, Dark, Michael J., additional, Milovancev, Milan, additional, Stromberg, Paul, additional, Williams, Bruce H., additional, Aubreville, Marc, additional, Avallone, Giancarlo, additional, Bolfa, Pompei, additional, Cullen, John, additional, Dennis, Michelle M., additional, Goldschmidt, Michael, additional, Luong, Richard, additional, Miller, Andrew D., additional, Miller, Margaret A., additional, Munday, John S., additional, Roccabianca, Paola, additional, Salas, Elisa N., additional, Schulman, F. Yvonne, additional, Laufer-Amorim, Renee, additional, Asakawa, Midori G., additional, Craig, Linden, additional, Dervisis, Nick, additional, Esplin, D. Glen, additional, George, Jeanne W., additional, Hauck, Marlene, additional, Kagawa, Yumiko, additional, Kiupel, Matti, additional, Linder, Keith, additional, Meichner, Kristina, additional, Marconato, Laura, additional, Oblak, Michelle L., additional, Santos, Renato L., additional, Simpson, R. Mark, additional, Tvedten, Harold, additional, and Whitley, Derick, additional

Published
2021
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49. Supplemental Material, sj-pdf-9-vet-10.1177_03009858211013712 - International Guidelines for Veterinary Tumor Pathology: A Call to Action

Author

Meuten, Donald J., Moore, Frances M., Donovan, Taryn A., Bertram, Christof A., Klopfleisch, Robert, Foster, Robert A., Smedley, Rebecca C., Dark, Michael J., Milovancev, Milan, Stromberg, Paul, Williams, Bruce H., Aubreville, Marc, Avallone, Giancarlo, Bolfa, Pompei, Cullen, John, Dennis, Michelle M., Goldschmidt, Michael, Luong, Richard, Miller, Andrew D., Miller, Margaret A., Munday, John S., Roccabianca, Paola, Salas, Elisa N., Schulman, F. Yvonne, Laufer-Amorim, Renee, Asakawa, Midori G., Craig, Linden, Dervisis, Nick, Esplin, D. Glen, George, Jeanne W., Hauck, Marlene, Kagawa, Yumiko, Kiupel, Matti, Linder, Keith, Meichner, Kristina, Marconato, Laura, Oblak, Michelle L., Santos, Renato L., Simpson, R. Mark, Tvedten, Harold, and Whitley, Derick

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-pdf-9-vet-10.1177_03009858211013712 for International Guidelines for Veterinary Tumor Pathology: A Call to Action by Donald J. Meuten, Frances M. Moore, Taryn A. Donovan, Christof A. Bertram, Robert Klopfleisch, Robert A. Foster, Rebecca C. Smedley, Michael J. Dark, Milan Milovancev, Paul Stromberg, Bruce H. Williams, Marc Aubreville, Giancarlo Avallone, Pompei Bolfa, John Cullen, Michelle M. Dennis, Michael Goldschmidt, Richard Luong, Andrew D. Miller, Margaret A. Miller, John S. Munday, Paola Roccabianca, Elisa N. Salas, F. Yvonne Schulman, Renee Laufer-Amorim, Midori G. Asakawa, Linden Craig, Nick Dervisis, D. Glen Esplin, Jeanne W. George, Marlene Hauck, Yumiko Kagawa, Matti Kiupel, Keith Linder, Kristina Meichner, Laura Marconato, Michelle L. Oblak, Renato L. Santos, R. Mark Simpson, Harold Tvedten and Derick Whitley in Veterinary Pathology

Published
2021
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50. Supplemental Material, sj-pdf-5-vet-10.1177_03009858211013712 - International Guidelines for Veterinary Tumor Pathology: A Call to Action

Author

Meuten, Donald J., Moore, Frances M., Donovan, Taryn A., Bertram, Christof A., Klopfleisch, Robert, Foster, Robert A., Smedley, Rebecca C., Dark, Michael J., Milovancev, Milan, Stromberg, Paul, Williams, Bruce H., Aubreville, Marc, Avallone, Giancarlo, Bolfa, Pompei, Cullen, John, Dennis, Michelle M., Goldschmidt, Michael, Luong, Richard, Miller, Andrew D., Miller, Margaret A., Munday, John S., Roccabianca, Paola, Salas, Elisa N., Schulman, F. Yvonne, Laufer-Amorim, Renee, Asakawa, Midori G., Craig, Linden, Dervisis, Nick, Esplin, D. Glen, George, Jeanne W., Hauck, Marlene, Kagawa, Yumiko, Kiupel, Matti, Linder, Keith, Meichner, Kristina, Marconato, Laura, Oblak, Michelle L., Santos, Renato L., Simpson, R. Mark, Tvedten, Harold, and Whitley, Derick

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-pdf-5-vet-10.1177_03009858211013712 for International Guidelines for Veterinary Tumor Pathology: A Call to Action by Donald J. Meuten, Frances M. Moore, Taryn A. Donovan, Christof A. Bertram, Robert Klopfleisch, Robert A. Foster, Rebecca C. Smedley, Michael J. Dark, Milan Milovancev, Paul Stromberg, Bruce H. Williams, Marc Aubreville, Giancarlo Avallone, Pompei Bolfa, John Cullen, Michelle M. Dennis, Michael Goldschmidt, Richard Luong, Andrew D. Miller, Margaret A. Miller, John S. Munday, Paola Roccabianca, Elisa N. Salas, F. Yvonne Schulman, Renee Laufer-Amorim, Midori G. Asakawa, Linden Craig, Nick Dervisis, D. Glen Esplin, Jeanne W. George, Marlene Hauck, Yumiko Kagawa, Matti Kiupel, Keith Linder, Kristina Meichner, Laura Marconato, Michelle L. Oblak, Renato L. Santos, R. Mark Simpson, Harold Tvedten and Derick Whitley in Veterinary Pathology

Published
2021
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